Akira Suzuki
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Akira Suzukichemistry Degrees
Chemistry
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#6792
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Inorganic Chemistry
#312
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#327
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Organic Chemistry
#1000
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#1130
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Chemistry
Akira Suzuki's Degrees
- PhD Chemistry Hokkaido University
- Masters Chemistry Hokkaido University
- Bachelors Chemistry Hokkaido University
Why Is Akira Suzuki Influential?
(Suggest an Edit or Addition)Akira Suzuki's Published Works
Published Works
- Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN (1998) (2539)
- Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. (2011) (1193)
- Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. (2000) (1145)
- High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice (1998) (833)
- Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN (2006) (785)
- Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. (2004) (620)
- T cell-specific loss of Pten leads to defects in central and peripheral tolerance. (2001) (614)
- Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways (2002) (608)
- Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells (2002) (509)
- Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease (2001) (467)
- Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. (2006) (420)
- High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. (2000) (380)
- Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. (2006) (307)
- Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1 (2007) (293)
- The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. (2005) (281)
- Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production (2003) (256)
- Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination (2003) (240)
- Mammalian phosphoinositide kinases and phosphatases. (2009) (239)
- Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes (2005) (237)
- Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis (190)
- Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells (2001) (176)
- Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. (2003) (175)
- Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11 (2011) (166)
- Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. (2007) (164)
- Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. (2004) (160)
- Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice (2015) (149)
- CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein. (1996) (144)
- Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. (2012) (135)
- Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation. (2007) (134)
- PPARγ contributes to PKM2 and HK2 expression in fatty liver (2012) (128)
- Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases (2011) (119)
- Phosphoinositide 3-Kinase-mediated Activation of Cofilin Phosphatase Slingshot and Its Role for Insulin-induced Membrane Protrusion* (2004) (119)
- Physiological functions of Pten in mouse tissues. (2003) (116)
- The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey (2008) (112)
- A simple algorithm to compute comprehensive Gröbner bases using Gröbner bases (2006) (112)
- Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ (2000) (109)
- The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death (2010) (108)
- Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. (2006) (103)
- Portrait of PTEN: Messages from mutant mice (2008) (101)
- Essential Role of Pten in Body Size Determination and Pancreatic β-Cell Homeostasis In Vivo (2006) (97)
- An alternative approach to comprehensive Gröbner bases (2002) (81)
- Nrf2 Enhances Cholangiocyte Expansion in Pten-Deficient Livers (2013) (81)
- Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. (2009) (80)
- Different Properties of SEK1 and MKK7 in Dual Phosphorylation of Stress-induced Activated Protein Kinase SAPK/JNK in Embryonic Stem Cells* (2003) (79)
- Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity. (2013) (72)
- Non‐alcoholic steatohepatitis and hepatocellular carcinoma: Lessons from hepatocyte‐specific phosphatase and tensin homolog (PTEN)‐deficient mice (2007) (72)
- The Stress Kinase Mitogen-Activated Protein Kinase Kinase (Mkk)7 Is a Negative Regulator of Antigen Receptor and Growth Factor Receptor–Induced Proliferation in Hematopoietic Cells (2001) (68)
- INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor. (2015) (67)
- Deletion of Pten in Pancreatic β-Cells Protects Against Deficient β-Cell Mass and Function in Mouse Models of Type 2 Diabetes (2010) (65)
- Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma. (2005) (64)
- Phosphoinositide 3-kinases in immunity: lessons from knockout mice. (2002) (61)
- Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α (2005) (60)
- The physiology of phosphoinositides. (2007) (59)
- Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex (2014) (57)
- Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. (2008) (56)
- A new PICTure of nucleolar stress (2012) (56)
- A Unified Nomenclature and Amino Acid Numbering for Human PTEN (2014) (55)
- Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine (2013) (53)
- Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge. (2006) (53)
- Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis. (2002) (50)
- The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC. (2015) (49)
- Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9 (2018) (49)
- Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B–containing lipoproteins (2008) (48)
- YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma (2020) (46)
- The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. (2007) (45)
- Capturing the mammalian Hippo: Elucidating its role in cancer (2013) (43)
- MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation (2017) (42)
- Aberrant Expression of Plastin-3 Via Copy Number Gain Induces the Epithelial–Mesenchymal Transition in Circulating Colorectal Cancer Cells (2014) (41)
- Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice (2008) (40)
- Targeting the Hippo signalling pathway for cancer treatment. (2016) (40)
- Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response (2009) (38)
- Boolean Gröbner bases (2011) (35)
- Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages (2008) (34)
- Nucleotide Oligomerization Binding Domain-Like Receptor Signaling Enhances Dendritic Cell-Mediated Cross-Priming In Vivo (2009) (32)
- Sex difference in the liver of hepatocyte‐specific Pten‐deficient mice: A model of nonalcoholic steatohepatitis (2009) (30)
- Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer (2017) (28)
- The role of Hippo‐YAP signaling in squamous cell carcinomas (2020) (27)
- Disruption of the mouse protein Ser/Thr phosphatase 2Cβ gene leads to early pre-implantation lethality (2007) (25)
- Inhibition of PTEN Tumor Suppressor Promotes the Generation of Induced Pluripotent Stem Cells. (2013) (25)
- Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium (2015) (24)
- Merlin/NF2-Lin28B-let-7 Is a Tumor-Suppressive Pathway that Is Cell-Density Dependent and Hippo Independent. (2016) (24)
- BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease. (2015) (24)
- Role of PTEN/PI3K pathway in endothelial cells. (2007) (22)
- Induction of gene encoding FABP4 in Pten‐null keratinocytes (2009) (22)
- RETRACTION: Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice (2004) (21)
- Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice (2004) (21)
- Hippo vs. Crab: tissue‐specific functions of the mammalian Hippo pathway (2017) (18)
- Essential Role of Pten in Body Size Determination and Pancreatic (cid:2) -Cell Homeostasis In Vivo (2006) (17)
- Neonatal estrogenic exposure suppresses PTEN-related endometrial carcinogenesis in recombinant mice (2006) (17)
- Development of a mouse model for testing therapeutic agents: the anticancer effect of dienogest on endometrial neoplasms (2016) (17)
- Altered Expression of Hippo Signaling Pathway Molecules in Intrahepatic Cholangiocarcinoma (2017) (16)
- Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. (2017) (16)
- HPK1 competes with ADAP for SLP‐76 binding and via Rap1 negatively affects T‐cell adhesion (2010) (16)
- Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice (2020) (15)
- Partial deletion of Pten in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone. (2008) (14)
- Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice (2016) (14)
- Mutual Contribution of Pten and Estrogen to Endometrial Carcinogenesis in a PtenloxP/loxP Mouse Model (2011) (14)
- PICT1 expression is a poor prognostic factor in non-small cell lung cancer (2014) (13)
- Loss of Brca 2 and p 53 Synergistically Promotes Genomic Instability and Deregulation of T-cell Apoptosis 1 (2002) (12)
- PTEN Deletion and Concomitant c-Myc Activation Do Not Lead to Tumor Formation in Pancreatic β Cells* (2009) (11)
- Nucleolar Stress Induces Ubiquitination-independent Proteasomal Degradation of PICT1 Protein* (2014) (11)
- 1 INPP 4 B is a PtdIns ( 3 , 4 , 5 ) P 3 phosphatase that can act as a tumor suppressor (2015) (10)
- Hippo pathway controls cell adhesion and context‐dependent cell competition to influence skin engraftment efficiency (2019) (10)
- A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation (2022) (9)
- ACGB on Varieties (2003) (9)
- Discrete comprehensive Gröbner bases (2001) (9)
- Leptin Improves Fatty Liver Independently of Insulin Sensitization and Appetite Suppression in Hepatocyte-Specific Pten-Deficient Mice with Insulin Hypersensitivity (2014) (8)
- Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation (2021) (8)
- Corrigendum: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ (2003) (7)
- Computation of inverses in residue class rings of parametric polynomial ideals (2009) (7)
- GRÖBNER BASES IN POLYNOMIAL RINGS OVER VON NEUMANN REGULAR RINGS — THEIR APPLICATIONS (2000) (7)
- Functional analysis of the tumour suppressor gene PTEN in murine B cells and keratinocytes. (2004) (7)
- Tumorigenesis facilitated by Pten deficiency in the skin: Evidence of p53‐Pten complex formation on the initiation phase (2004) (6)
- Inhibition of PTEN Tumor Suppressor Promotes the Generation of Induced Pluripotent Stem Cells (2011) (6)
- Computing Gröbner Bases within Linear Algebra (2009) (6)
- Clinical Significance of PICT1 in Patients of Hepatocellular Carcinoma with Wild-Type TP53 (2013) (6)
- [Hepatocyte-specific Pten deficient mice]. (2006) (6)
- The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors (2015) (5)
- TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands (2021) (5)
- FEAT enhances INSL3 expression in testicular Leydig cells (2018) (4)
- DISCRETE COMPREHENSIVE GRÖBNER BASES, II (2003) (4)
- Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells. (2013) (3)
- MOB1 regulates thymocyte egress and T‐cell survival in mice in a YAP1‐independent manner (2019) (3)
- Erratum: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ (Nature (2000) 406 (897-902)) (2003) (3)
- Implementation of CGS and CGB on Risa/Asir and other computer algebra systems using Suzuki-Sato algorithm (2007) (2)
- [Tumor suppressor gene PTEN and non-alcoholic steatohepatitis (NASH)]. (2005) (2)
- Erratum: Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice (Nature Medicine (2004) 10 (1208-1215)) (2005) (2)
- Computation of Full Comprehensive Gröbner Bases (2005) (2)
- Erratum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice (Scientific Reports (2016) 6 (22991) DOI: 10.1038/srep22991) (2016) (2)
- The Pten/PI3K pathway governs the homeostasis of V (cid:1) 14 i NKT cells (2006) (2)
- Generalized Discrete Comprehensive Gröbner Bases (2003) (1)
- Hepatocyte-Specific PTEN Deficiency Improves Obesity in the Leptin-Deficient OB/OB Mouse (2011) (1)
- S1837 UDCA Improves Liver Inflammation of NASH by Reducing ROS Levels and Increasing the Expression of NRF2-Regulated Antioxident Genes-an Examination Using Hepatocyte-Specific PTEN Deficient Mice (2010) (1)
- Generalized Discrete Comprehensive Grobner Bases (Computer Algebra : Algorithms, Implementations and Applications) (2003) (1)
- Stabilization mechanism for PICT1 oncoprotein (2017) (0)
- Merlin regulates the let-7 biogenesis via Lin28B suppression in a cell density-dependent manner (2015) (0)
- S1901 Ursodeoxychoric Acid Blocks Progression of NASH -An Examination Using Hepatocyte-Specific PTEN Deficient Mice- (2008) (0)
- Abstract A31: Transcriptional addiction to YAP1—a major driving force of oral cancer carcinogenesis and evolution? (2020) (0)
- Title Hepatocyte-specific Pten deficiency results insteatohepatitis and hepatocellular carcinomas (0)
- Corrigendum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice (2016) (0)
- Searching for signals controlling Hippo pathway effectors YAP/TAZ (2017) (0)
- 609: Functional Analysis of a Tumor Suppressor Gene PTEN in the Urothelial Carcinogenesis Using a Conditional PTEN-deficient Mouse Model (2006) (0)
- [692] SEX DIFFERENCES IN HEPATOCYTE-SPECIFIC Pten-DEFICIENT MICE SHOWING STEATOHEPATITIS WITHOUT ETHANOL CHALLENGE (2007) (0)
- [From fatty liver to liver cancer--new development in non-alcoholic steatohepatitis (NASH) using animal models]. (2005) (0)
- Abstract PR9: PICT1/GLTSCR2 is a critical nucleolar binding partner of RPL11 that regulates the MDM2-p53 pathway and tumor growth (2011) (0)
- [Role of PTEN tumor suppressor gene in disease: PTEN-deficient mice]. (2008) (0)
- A method for studying quality of phosphoinositides (2016) (0)
- SUPPRESSION OF SPONTANEOUS CARCINOGENESIS IN KERATINOCYTE ‑ SPECIFIC PTEN ‑ DEFICIENT MICE WITH SELECTIVE INHIBITION OF PI3K ISOFORMS (2009) (0)
- Computing gröbner bases within linear algebra and its implementation (2010) (0)
- Full Comprehensive Gröbner Bases (2005) (0)
- thrifty phenotype: effect of gender glycerol-3-phosphate dehydrogenase gene exhibit a Mice with deletion of the mitochondrial (2006) (0)
- Function of MOB1 in murine liver (2015) (0)
- Study of gene expression in livers derived from hepatocyte-specific Pten-deficient mice using DNA microarray analysis --Identification of candidate genes of nonalchoholic steatohepatitis-- (2005) (0)
- [746] N-ACETYL-CYSTEIN BLOCKS PROGRESSION OF NASH BY REDUCING REACTIVE OXYGEN SPECIES. AN EXAMINATION USING HEPATOCYTE-SPECIFIC Pten DEFICIENT MICE (2007) (0)
- Role of Mob1a/1b in murine salivary glands (2016) (0)
- The role of PTEN tumor suppressor gene in disease: Message from PTEN -deficient mice (2008) (0)
- Computation of inverses in residue class rings with parameters (2009) (0)
- OSTEOBLAST ‑ SPECIFIC PTEN DEFICIENCY RESULTS IN INCREASED BONE FORMATION (2009) (0)
- Increased angiogenesis and accelerated tumour growth in Tie 2 CrePtenflox / + mice (2007) (0)
- [716] EICOSAPENTAENOIC ACID IMPROVES STEATOHEPATITIS IN NEWLY ESTABLISHED MICE MODEL OF NONALCOHOLIC STEATOHEPATITIS (2007) (0)
- Abstract B16: Transcriptional addiction to YAP1—the major driving force of oral cancer carcinogenesis and evolution (2020) (0)
- Reduced PTEN Protein in Human Bladder Cancer Patients Hyperplasia and Carcinomas in Pten-Deficient Mice and Updated (2006) (0)
- [Non-alcoholic steatohepatitis (NASH). 4. Physiopathological explanation (a lesson from experimental models)]. (2006) (0)
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What Schools Are Affiliated With Akira Suzuki?
Akira Suzuki is affiliated with the following schools: