Alain Israël
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Alain Israëlbiology Degrees
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Cell Biology
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Molecular Biology
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Biology
Alain Israël's Degrees
- Bachelors Biochemistry University of California, Berkeley
- PhD Molecular Biology Stanford University
Why Is Alain Israël Influential?
(Suggest an Edit or Addition)Alain Israël's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. (2000) (1168)
- Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation (1998) (1058)
- The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination (2003) (1045)
- The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product (1990) (795)
- X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling (2001) (781)
- The Notch1 receptor is cleaved constitutively by a furin-like convertase. (1998) (752)
- The IKK complex, a central regulator of NF-kappaB activation. (2010) (621)
- Genomic rearrangement in NEMO impairs NF-κB activation and is a cause of incontinentia pigmenti (2000) (531)
- NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti (2000) (396)
- The IKK complex: an integrator of all signals that activate NF-κB? (2000) (396)
- Immunodeficiency, auto-inflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency (2012) (372)
- I kappa B epsilon, a novel member of the IκB family, controls RelA and cRel NF‐κB activity (1997) (368)
- Delta-1 Activation of Notch-1 Signaling Results inHES-1 Transactivation (1998) (365)
- The precursor of NF-κB p50 has IκB-like functions (1992) (359)
- TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO–IKK supramolecular structures (2014) (356)
- NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats (1992) (352)
- Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. (1998) (351)
- Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor* (2001) (338)
- IκB proteins: structure, function and regulation (1997) (318)
- Detailed analysis of the mouse H-2Kb promoter: Enhancer-like sequences and their role in the regulation of class I gene expression (1986) (314)
- A hypermorphic IκBα mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency (2003) (312)
- Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. (2000) (302)
- Promoter analysis of the gene encoding the I kappa B‐alpha/MAD3 inhibitor of NF‐kappa B: positive regulation by members of the rel/NF‐kappa B family. (1993) (284)
- Invasive Shigella flexneri Activates NF-κB Through a Lipopolysaccharide-Dependent Innate Intracellular Response and Leads to IL-8 Expression in Epithelial Cells1 (2000) (276)
- The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes. (2002) (269)
- TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B‐like enhancer binding activity which displaces constitutive factors. (1989) (264)
- The characterization of the promoter of the gene encoding the p50 subunit of NF‐kappa B indicates that it participates in its own regulation. (1992) (264)
- X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production (2006) (263)
- Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor (2004) (242)
- IκBα is a target for the mitogen‐activated 90 kDa ribosomal S6 kinase (1997) (237)
- The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase (2003) (225)
- The regulation and expression of MHC class I genes. (1990) (225)
- Mature T cells depend on signaling through the IKK complex. (2003) (222)
- N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity (1995) (215)
- Itch/AIP4 mediates Deltex degradation through the formation of K29‐linked polyubiquitin chains (2006) (207)
- From Calcium to NF-κB Signaling Pathways in Neurons (2003) (205)
- NF-κB Regulates Spatial Memory Formation and Synaptic Plasticity through Protein Kinase A/CREB Signaling (2006) (199)
- NEMO specifically recognizes K63‐linked poly‐ubiquitin chains through a new bipartite ubiquitin‐binding domain (2009) (188)
- Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless. (1994) (182)
- Cytoplasmic retention, DNA binding and processing of the NF‐kappa B p50 precursor are controlled by a small region in its C‐terminus. (1991) (181)
- NEMO/IKK gamma-deficient mice model incontinentia pigmenti. (2000) (175)
- Forebrain-Specific Neuronal Inhibition of Nuclear Factor-κB Activity Leads to Loss of Neuroprotection (2003) (173)
- Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation. (1995) (163)
- A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. (2003) (155)
- Processing of the precursor of NF-κB by the HIV-1 protease during acute infection (1991) (153)
- SCFβ‐TrCP ubiquitin ligase‐mediated processing of NF‐κB p 105 requires phosphorylation of its C‐terminus by IκB kinase (2000) (147)
- Tumor necrosis factor stimulates transcription of HIV-1 in human T lymphocytes, independently and synergistically with mitogens. (1989) (145)
- Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation. (2004) (141)
- I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. (1997) (141)
- Atypical forms of incontinentia pigmenti in male individuals result from mutations of a cytosine tract in exon 10 of NEMO (IKK-gamma). (2001) (140)
- AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand (2008) (139)
- I kappa B proteins: structure, function and regulation. (1997) (134)
- Structural Motifs Involved in Ubiquitin-Mediated Processing of the NF-κB Precursor p105: Roles of the Glycine-Rich Region and a Downstream Ubiquitination Domain (1999) (131)
- Purification of KBF1, a common factor binding to both H‐2 and beta 2‐microglobulin enhancers. (1987) (129)
- Direct Association and Nuclear Import of the Hepatitis B Virus X Protein with the NF-κB Inhibitor IκBα (1999) (123)
- Inhibition of transcription factors belonging to the rel/NF‐kappa B family by a transdominant negative mutant. (1991) (122)
- The IKK complex: an integrator of all signals that activate NF-kappaB? (2000) (121)
- Phorbol Esters and Cytokines Regulate the Expression of theNEMO-related Protein, a Molecule Involved in a NF-κB-independent Pathway* (2000) (120)
- Functional Interaction between SEL-10 , an F-box Protein , and the Nuclear Form of Activated Notch 1 Receptor * (2001) (118)
- T-cell-receptor- and B-cell-receptor-mediated activation of NF-κB in lymphocytes (2004) (117)
- A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genes. (1987) (113)
- Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome (1998) (112)
- Regulation of IkappaBbeta degradation. Similarities to and differences from IkappaBalpha. (1997) (108)
- From calcium to NF-kappa B signaling pathways in neurons. (2003) (107)
- Negative feedback loop in T cell activation through IκB kinase-induced phosphorylation and degradation of Bcl10 (2007) (102)
- The IKK Complex , a Central Regulator of NFk B Activation (2010) (102)
- A role for phosphorylation and degradation in the control of NF-κB activity (1995) (101)
- Deciphering the pathway from the TCR to NF-κB (2006) (99)
- Siah-1 binds and regulates the function of Numb (2001) (96)
- The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity (2008) (96)
- NEMO Trimerizes through Its Coiled-coil C-terminal Domain* (2002) (88)
- Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3 (1994) (87)
- Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression. (2012) (83)
- NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-κB by Human T-Lymphotropic Virus Type 1 Tax Protein (2009) (81)
- The Trimerization Domain of Nemo Is Composed of the Interacting C-terminal CC2 and LZ Coiled-coil Subdomains* (2004) (79)
- Phosphorylation of p105 PEST Sequences via a Redox-insensitive Pathway Up-regulates Processing to p50 NF-B (*) (1996) (78)
- SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. (2000) (75)
- The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation (2010) (73)
- Induction of the NF-κB Cascade by Recruitment of the Scaffold Molecule NEMO to the T Cell Receptor (2003) (71)
- NEMO/IKK?: linking NF-?B to human disease (2001) (64)
- The Notch Ligand Delta1 Recruits Dlg1 at Cell-Cell Contacts and Regulates Cell Migration*[boxs] (2004) (64)
- Listeriolysin O secreted by Listeria monocytogenes induces NF‐κB signalling by activating the IκB kinase complex (2002) (63)
- Deciphering the pathway from the TCR to NF-kappaB. (2006) (61)
- The Ubiquitin-specific Protease 12 (USP12) Is a Negative Regulator of Notch Signaling Acting on Notch Receptor Trafficking toward Degradation* (2012) (59)
- Inhibition of NF-κB Activation by Peptides Targeting NF-κB Essential Modulator (NEMO) Oligomerization* (2004) (57)
- Mechanisms of ubiquitin-mediated, limited processingof the NF-κB1 precursor protein p105 (2001) (56)
- IκBε-Deficient Mice: Reduction of One T Cell Precursor Subspecies and Enhanced Ig Isotype Switching and Cytokine Synthesis (1999) (56)
- Visualization of lymphatic vessels through NF-kappaB activity. (2004) (56)
- IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. (1997) (56)
- Injury‐induced NF‐κB activation in the hippocampus: implications for neuronal survival (2004) (53)
- &agr;-arrestin 1 (ARRDC1) and &bgr;-arrestins cooperate to mediate Notch degradation in mammals (2013) (52)
- Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha. (1999) (51)
- IκBα/IκBε deficiency reveals that a critical NF-κB dosage is required for lymphocyte survival (2003) (50)
- Altered Expression of Tyrosine Kinases of the Src and Syk Families in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines (1999) (50)
- Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells (2004) (47)
- The Adaptor-associated Kinase 1, AAK1, Is a Positive Regulator of the Notch Pathway* (2011) (47)
- Arachidonic Acid Differentially Affects Basal and Lipopolysaccharide-Induced sPLA2-IIA Expression in Alveolar Macrophages through NF-κB and PPAR-γ–Dependent Pathways (2002) (47)
- Activation of NF-κB in the mouse spinal cord following sciatic nerve transection (2005) (45)
- Alzheimer's disease: In search of γ-secretase (1999) (45)
- DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding. (2010) (44)
- Invasive Shigella flexneriActivates NF-kB Through a Lipopolysaccharide-Dependent Innate Intracellular Response and Leads to IL-8 Expression in Epithelial Cells (2000) (44)
- T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes. (2004) (42)
- NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats. (1992) (40)
- A Point Mutation in NEMO Associated with Anhidrotic Ectodermal Dysplasia with Immunodeficiency Pathology Results in Destabilization of the Oligomer and Reduces Lipopolysaccharide- and Tumor Necrosis Factor-mediated NF-κB Activation* (2006) (40)
- The precursor of NF-kappa B p50 has I kappa B-like functions. (1992) (39)
- Combined deficiency in IκBα and IκBϵ reveals a critical window of NF-κB activity in natural killer cell differentiation (2004) (34)
- Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor. (2003) (34)
- Listeriolysin O secreted by Listeria monocytogenes induces NF-kappaB signalling by activating the IkappaB kinase complex. (2002) (34)
- IKK regulation and human genetics. (2011) (33)
- The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors (2014) (32)
- IkappaBepsilon-deficient mice: reduction of one T cell precursor subspecies and enhanced Ig isotype switching and cytokine synthesis. (1999) (32)
- NF-κB activation: nondegradative ubiquitination implicates NEMO (2006) (31)
- NEMO/IKK gamma: linking NF-kappa B to human disease. (2001) (30)
- Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105. (2001) (30)
- Signal transduction: A regulator branches out (2003) (29)
- IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival. (2003) (29)
- Arachidonic acid differentially affects basal and lipopolysaccharide-induced sPLA(2)-IIA expression in alveolar macrophages through NF-kappaB and PPAR-gamma-dependent pathways. (2002) (28)
- Processing of the precursor of NF-kappa B by the HIV-1 protease during acute infection. (1991) (26)
- NF‐κB is developmentally regulated during spermatogenesis in mice (2000) (26)
- Activation of NF-κB by the Tax Protein of HTLV-1 (1995) (26)
- Control of NF-κB Activity by the IκBβ Inhibitor (1997) (25)
- Two factors, IRF1 and KBF1/NF-kappa B, cooperate during induction of MHC class I gene expression by interferon alpha beta or Newcastle disease virus. (1993) (25)
- Phosphorylation of p105 PEST sequence via a redox-insensitive pathway up-regulates processing of p50 NF-kappaB. (1996) (25)
- Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization. (2004) (23)
- Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti (2016) (20)
- In vivo identification of lymphocyte subsets exhibiting transcriptionally active NF-kappaB/Rel complexes. (2000) (20)
- Combined deficiency in IkappaBalpha and IkappaBepsilon reveals a critical window of NF-kappaB activity in natural killer cell differentiation. (2004) (19)
- Negative regulation of the gene for H-2Kb class I antigen by adenovirus 12-E1A is mediated by a CAA repeated element. (1993) (19)
- A role for phosphorylation and degradation in the control of NF-kappa B activity. (1995) (19)
- Activation of NF-kappa B by the Tax protein of HTLV-1. (1995) (19)
- NF-kappa B is developmentally regulated during spermatogenesis in mice. (2000) (18)
- Signal transduction. IkappaB kinase all zipped up. (1997) (17)
- A Glycosphingolipid Binding Domain Controls Trafficking and Activity of the Mammalian Notch Ligand Delta-Like 1 (2013) (17)
- Preliminary characterization of the particles from productive and abortive infections of L cells by fowl plague virus. (1979) (16)
- Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105 (1995) (16)
- Kappa B binding proteins are constitutively expressed in an IL-2 autocrine human T cell line. (1991) (15)
- NF-kappaB activation: Nondegradative ubiquitination implicates NEMO. (2006) (15)
- A temperature-dependent host range mutant of fowl plague virus (FPV). (1980) (15)
- Reconstitution of the NF‐κB System in Saccharomyces cerevisiae for Isolation of Effectors by Phenotype Modulation (1997) (14)
- NF-κB is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus (2003) (13)
- Regulation of IκBβ Degradation (1997) (13)
- Cooperativity between an Upstream TATA-like Sequence and a CAA Repeated Element Mediates E1A-dependent Negative Repression of the H-2K Class I Gene (*) (1995) (12)
- NF-κB Defects in Humans: The NEMO/Incontinentia Pigmenti Connection (2000) (11)
- Control of NF-kappa B activity by the I kappa B beta inhibitor. (1997) (11)
- Characterization of a new tissue-specific transcription factor binding to the simian virus 40 enhancer TC-II (NF-kappa B) element (1992) (10)
- NF-AT comes under control (1994) (7)
- Two NEMO-like Ubiquitin-Binding Domains in CEP55 Differently Regulate Cytokinesis (2019) (7)
- Generation and Characterization of Mutant Cell Lines Defective in γ-Secretase Processing of Notch and Amyloid Precursor Protein* (2005) (7)
- Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate (2002) (6)
- NF-kappaB is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus. (2003) (5)
- Genotypic and phenotypic characterization of a mammalian cell-adapted mutant of fowl plague virus (FPV). (1980) (4)
- NF-kappa B defects in humans: the NEMO/incontinentia pigmenti connection. (2000) (4)
- Productive and abortive infection of L cells by fowl plague virus (FPV): comparison of in vivo and in vitro translation products of the virus mRNAs. (1980) (4)
- Control of Notch Activity by the Ubiquitin-Proteasome Pathway (2002) (3)
- Two factors, IRF1 and KBF1/NF-κB, cooperate during induction of MHC class I gene expression by interferon αβ or Newcastle disease virus (1993) (3)
- Rapid isolation of mouse primary fibroblasts: a tool for the analysis of transgenic mice (1997) (3)
- NF-κB activation by CD26 antigen is independent of dipeptidyl peptidase IV activity (1997) (2)
- The role of the adenovirus E1a region in transformation and oncogenesis (1986) (2)
- Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein. (2005) (1)
- Latex fetuin spheres as probes for influenza virus neuraminidase in productively and abortively infected cells (2005) (1)
- Rel Proteins and Their Inhibitors: A Balancing Act (1997) (1)
- [The rel/NF-kappa B family of transcription factors: a novel mechanism to control gene expression]. (1992) (1)
- Vertegaal , mature proteins and have sequence homology within the (2013) (0)
- Isotype Switching and Cytokine Synthesis Precursor Subspecies and Enhanced Ig -Deficient Mice: Reduction of One T Cell e B k I (1999) (0)
- NF-кB in Genetic Disorders (2003) (0)
- Correction (2004) (0)
- Complex Regulation of MHC Class I Expression: Constitutive and Modulated Patterns of Expression (1989) (0)
- Cooperatively between an upstream TATA-like sequence and a CAA repeated element mediates E1A-dependent negative repression of the H-2Kb class I gene. (1995) (0)
- and response to inducers of NF-kappa B activity . degradation of MAD 3 / I kappa B alpha in Nand C-terminal sequences control (1995) (0)
- [Human pathologies associated with NF-kappaB defects]. (2004) (0)
- DDH192 1763..1773 (2004) (0)
- NF-_B and Associated Human Genetic Pathologies (2006) (0)
- ThehumanJKrecombination signal sequence binding protein (RBP-JK) targets theEpstein-Barr virus EBNA2protein toitsDNA responsive elements (1994) (0)
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