Alain Israël

Alain Israël's AcademicInfluence.com Rankings

Alain Israël

Biology

#13408

World Rank

#16953

Historical Rank

Cell Biology

#743

World Rank

#758

Historical Rank

Molecular Biology

#2264

World Rank

#2298

Historical Rank

Neuroscience

#2322

World Rank

#2386

Historical Rank

biology Degrees

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Biology

Alain Israël's Degrees

Bachelors Biochemistry University of California, Berkeley
PhD Molecular Biology Stanford University

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Alain Israël's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. (2000) (1168)
Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation (1998) (1058)
The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination (2003) (1045)
The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product (1990) (795)
X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling (2001) (781)
The Notch1 receptor is cleaved constitutively by a furin-like convertase. (1998) (752)
The IKK complex, a central regulator of NF-kappaB activation. (2010) (621)
Genomic rearrangement in NEMO impairs NF-κB activation and is a cause of incontinentia pigmenti (2000) (531)
NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti (2000) (396)
The IKK complex: an integrator of all signals that activate NF-κB? (2000) (396)
Immunodeficiency, auto-inflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency (2012) (372)
I kappa B epsilon, a novel member of the IκB family, controls RelA and cRel NF‐κB activity (1997) (368)
Delta-1 Activation of Notch-1 Signaling Results inHES-1 Transactivation (1998) (365)
The precursor of NF-κB p50 has IκB-like functions (1992) (359)
TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO–IKK supramolecular structures (2014) (356)
NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats (1992) (352)
Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. (1998) (351)
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor* (2001) (338)
IκB proteins: structure, function and regulation (1997) (318)
Detailed analysis of the mouse H-2Kb promoter: Enhancer-like sequences and their role in the regulation of class I gene expression (1986) (314)
A hypermorphic IκBα mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency (2003) (312)
Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. (2000) (302)
Promoter analysis of the gene encoding the I kappa B‐alpha/MAD3 inhibitor of NF‐kappa B: positive regulation by members of the rel/NF‐kappa B family. (1993) (284)
Invasive Shigella flexneri Activates NF-κB Through a Lipopolysaccharide-Dependent Innate Intracellular Response and Leads to IL-8 Expression in Epithelial Cells1 (2000) (276)
The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes. (2002) (269)
TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B‐like enhancer binding activity which displaces constitutive factors. (1989) (264)
The characterization of the promoter of the gene encoding the p50 subunit of NF‐kappa B indicates that it participates in its own regulation. (1992) (264)
X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production (2006) (263)
Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor (2004) (242)
IκBα is a target for the mitogen‐activated 90 kDa ribosomal S6 kinase (1997) (237)
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase (2003) (225)
The regulation and expression of MHC class I genes. (1990) (225)
Mature T cells depend on signaling through the IKK complex. (2003) (222)
N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity (1995) (215)
Itch/AIP4 mediates Deltex degradation through the formation of K29‐linked polyubiquitin chains (2006) (207)
From Calcium to NF-κB Signaling Pathways in Neurons (2003) (205)
NF-κB Regulates Spatial Memory Formation and Synaptic Plasticity through Protein Kinase A/CREB Signaling (2006) (199)
NEMO specifically recognizes K63‐linked poly‐ubiquitin chains through a new bipartite ubiquitin‐binding domain (2009) (188)
Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless. (1994) (182)
Cytoplasmic retention, DNA binding and processing of the NF‐kappa B p50 precursor are controlled by a small region in its C‐terminus. (1991) (181)
NEMO/IKK gamma-deficient mice model incontinentia pigmenti. (2000) (175)
Forebrain-Specific Neuronal Inhibition of Nuclear Factor-κB Activity Leads to Loss of Neuroprotection (2003) (173)
Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation. (1995) (163)
A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. (2003) (155)
Processing of the precursor of NF-κB by the HIV-1 protease during acute infection (1991) (153)
SCFβ‐TrCP ubiquitin ligase‐mediated processing of NF‐κB p 105 requires phosphorylation of its C‐terminus by IκB kinase (2000) (147)
Tumor necrosis factor stimulates transcription of HIV-1 in human T lymphocytes, independently and synergistically with mitogens. (1989) (145)
Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation. (2004) (141)
I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. (1997) (141)
Atypical forms of incontinentia pigmenti in male individuals result from mutations of a cytosine tract in exon 10 of NEMO (IKK-gamma). (2001) (140)
AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand (2008) (139)
I kappa B proteins: structure, function and regulation. (1997) (134)
Structural Motifs Involved in Ubiquitin-Mediated Processing of the NF-κB Precursor p105: Roles of the Glycine-Rich Region and a Downstream Ubiquitination Domain (1999) (131)
Purification of KBF1, a common factor binding to both H‐2 and beta 2‐microglobulin enhancers. (1987) (129)
Direct Association and Nuclear Import of the Hepatitis B Virus X Protein with the NF-κB Inhibitor IκBα (1999) (123)
Inhibition of transcription factors belonging to the rel/NF‐kappa B family by a transdominant negative mutant. (1991) (122)
The IKK complex: an integrator of all signals that activate NF-kappaB? (2000) (121)
Phorbol Esters and Cytokines Regulate the Expression of theNEMO-related Protein, a Molecule Involved in a NF-κB-independent Pathway* (2000) (120)
Functional Interaction between SEL-10 , an F-box Protein , and the Nuclear Form of Activated Notch 1 Receptor * (2001) (118)
T-cell-receptor- and B-cell-receptor-mediated activation of NF-κB in lymphocytes (2004) (117)
A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genes. (1987) (113)
Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome (1998) (112)
Regulation of IkappaBbeta degradation. Similarities to and differences from IkappaBalpha. (1997) (108)
From calcium to NF-kappa B signaling pathways in neurons. (2003) (107)
Negative feedback loop in T cell activation through IκB kinase-induced phosphorylation and degradation of Bcl10 (2007) (102)
The IKK Complex , a Central Regulator of NFk B Activation (2010) (102)
A role for phosphorylation and degradation in the control of NF-κB activity (1995) (101)
Deciphering the pathway from the TCR to NF-κB (2006) (99)
Siah-1 binds and regulates the function of Numb (2001) (96)
The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity (2008) (96)
NEMO Trimerizes through Its Coiled-coil C-terminal Domain* (2002) (88)
Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3 (1994) (87)
Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression. (2012) (83)
NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-κB by Human T-Lymphotropic Virus Type 1 Tax Protein (2009) (81)
The Trimerization Domain of Nemo Is Composed of the Interacting C-terminal CC2 and LZ Coiled-coil Subdomains* (2004) (79)
Phosphorylation of p105 PEST Sequences via a Redox-insensitive Pathway Up-regulates Processing to p50 NF-B (*) (1996) (78)
SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. (2000) (75)
The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation (2010) (73)
Induction of the NF-κB Cascade by Recruitment of the Scaffold Molecule NEMO to the T Cell Receptor (2003) (71)
NEMO/IKK?: linking NF-?B to human disease (2001) (64)
The Notch Ligand Delta1 Recruits Dlg1 at Cell-Cell Contacts and Regulates Cell Migration*[boxs] (2004) (64)
Listeriolysin O secreted by Listeria monocytogenes induces NF‐κB signalling by activating the IκB kinase complex (2002) (63)
Deciphering the pathway from the TCR to NF-kappaB. (2006) (61)
The Ubiquitin-specific Protease 12 (USP12) Is a Negative Regulator of Notch Signaling Acting on Notch Receptor Trafficking toward Degradation* (2012) (59)
Inhibition of NF-κB Activation by Peptides Targeting NF-κB Essential Modulator (NEMO) Oligomerization* (2004) (57)
Mechanisms of ubiquitin-mediated, limited processingof the NF-κB1 precursor protein p105 (2001) (56)
IκBε-Deficient Mice: Reduction of One T Cell Precursor Subspecies and Enhanced Ig Isotype Switching and Cytokine Synthesis (1999) (56)
Visualization of lymphatic vessels through NF-kappaB activity. (2004) (56)
IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. (1997) (56)
Injury‐induced NF‐κB activation in the hippocampus: implications for neuronal survival (2004) (53)
&agr;-arrestin 1 (ARRDC1) and &bgr;-arrestins cooperate to mediate Notch degradation in mammals (2013) (52)
Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha. (1999) (51)
IκBα/IκBε deficiency reveals that a critical NF-κB dosage is required for lymphocyte survival (2003) (50)
Altered Expression of Tyrosine Kinases of the Src and Syk Families in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines (1999) (50)
Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells (2004) (47)
The Adaptor-associated Kinase 1, AAK1, Is a Positive Regulator of the Notch Pathway* (2011) (47)
Arachidonic Acid Differentially Affects Basal and Lipopolysaccharide-Induced sPLA2-IIA Expression in Alveolar Macrophages through NF-κB and PPAR-γ–Dependent Pathways (2002) (47)
Activation of NF-κB in the mouse spinal cord following sciatic nerve transection (2005) (45)
Alzheimer's disease: In search of γ-secretase (1999) (45)
DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding. (2010) (44)
Invasive Shigella flexneriActivates NF-kB Through a Lipopolysaccharide-Dependent Innate Intracellular Response and Leads to IL-8 Expression in Epithelial Cells (2000) (44)
T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes. (2004) (42)
NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats. (1992) (40)
A Point Mutation in NEMO Associated with Anhidrotic Ectodermal Dysplasia with Immunodeficiency Pathology Results in Destabilization of the Oligomer and Reduces Lipopolysaccharide- and Tumor Necrosis Factor-mediated NF-κB Activation* (2006) (40)
The precursor of NF-kappa B p50 has I kappa B-like functions. (1992) (39)
Combined deficiency in IκBα and IκBϵ reveals a critical window of NF-κB activity in natural killer cell differentiation (2004) (34)
Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor. (2003) (34)
Listeriolysin O secreted by Listeria monocytogenes induces NF-kappaB signalling by activating the IkappaB kinase complex. (2002) (34)
IKK regulation and human genetics. (2011) (33)
The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors (2014) (32)
IkappaBepsilon-deficient mice: reduction of one T cell precursor subspecies and enhanced Ig isotype switching and cytokine synthesis. (1999) (32)
NF-κB activation: nondegradative ubiquitination implicates NEMO (2006) (31)
NEMO/IKK gamma: linking NF-kappa B to human disease. (2001) (30)
Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105. (2001) (30)
Signal transduction: A regulator branches out (2003) (29)
IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival. (2003) (29)
Arachidonic acid differentially affects basal and lipopolysaccharide-induced sPLA(2)-IIA expression in alveolar macrophages through NF-kappaB and PPAR-gamma-dependent pathways. (2002) (28)
Processing of the precursor of NF-kappa B by the HIV-1 protease during acute infection. (1991) (26)
NF‐κB is developmentally regulated during spermatogenesis in mice (2000) (26)
Activation of NF-κB by the Tax Protein of HTLV-1 (1995) (26)
Control of NF-κB Activity by the IκBβ Inhibitor (1997) (25)
Two factors, IRF1 and KBF1/NF-kappa B, cooperate during induction of MHC class I gene expression by interferon alpha beta or Newcastle disease virus. (1993) (25)
Phosphorylation of p105 PEST sequence via a redox-insensitive pathway up-regulates processing of p50 NF-kappaB. (1996) (25)
Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization. (2004) (23)
Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti (2016) (20)
In vivo identification of lymphocyte subsets exhibiting transcriptionally active NF-kappaB/Rel complexes. (2000) (20)
Combined deficiency in IkappaBalpha and IkappaBepsilon reveals a critical window of NF-kappaB activity in natural killer cell differentiation. (2004) (19)
Negative regulation of the gene for H-2Kb class I antigen by adenovirus 12-E1A is mediated by a CAA repeated element. (1993) (19)
A role for phosphorylation and degradation in the control of NF-kappa B activity. (1995) (19)
Activation of NF-kappa B by the Tax protein of HTLV-1. (1995) (19)
NF-kappa B is developmentally regulated during spermatogenesis in mice. (2000) (18)
Signal transduction. IkappaB kinase all zipped up. (1997) (17)
A Glycosphingolipid Binding Domain Controls Trafficking and Activity of the Mammalian Notch Ligand Delta-Like 1 (2013) (17)
Preliminary characterization of the particles from productive and abortive infections of L cells by fowl plague virus. (1979) (16)
Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105 (1995) (16)
Kappa B binding proteins are constitutively expressed in an IL-2 autocrine human T cell line. (1991) (15)
NF-kappaB activation: Nondegradative ubiquitination implicates NEMO. (2006) (15)
A temperature-dependent host range mutant of fowl plague virus (FPV). (1980) (15)
Reconstitution of the NF‐κB System in Saccharomyces cerevisiae for Isolation of Effectors by Phenotype Modulation (1997) (14)
NF-κB is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus (2003) (13)
Regulation of IκBβ Degradation (1997) (13)
Cooperativity between an Upstream TATA-like Sequence and a CAA Repeated Element Mediates E1A-dependent Negative Repression of the H-2K Class I Gene (*) (1995) (12)
NF-κB Defects in Humans: The NEMO/Incontinentia Pigmenti Connection (2000) (11)
Control of NF-kappa B activity by the I kappa B beta inhibitor. (1997) (11)
Characterization of a new tissue-specific transcription factor binding to the simian virus 40 enhancer TC-II (NF-kappa B) element (1992) (10)
NF-AT comes under control (1994) (7)
Two NEMO-like Ubiquitin-Binding Domains in CEP55 Differently Regulate Cytokinesis (2019) (7)
Generation and Characterization of Mutant Cell Lines Defective in γ-Secretase Processing of Notch and Amyloid Precursor Protein* (2005) (7)
Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate (2002) (6)
NF-kappaB is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus. (2003) (5)
Genotypic and phenotypic characterization of a mammalian cell-adapted mutant of fowl plague virus (FPV). (1980) (4)
NF-kappa B defects in humans: the NEMO/incontinentia pigmenti connection. (2000) (4)
Productive and abortive infection of L cells by fowl plague virus (FPV): comparison of in vivo and in vitro translation products of the virus mRNAs. (1980) (4)
Control of Notch Activity by the Ubiquitin-Proteasome Pathway (2002) (3)
Two factors, IRF1 and KBF1/NF-κB, cooperate during induction of MHC class I gene expression by interferon αβ or Newcastle disease virus (1993) (3)
Rapid isolation of mouse primary fibroblasts: a tool for the analysis of transgenic mice (1997) (3)
NF-κB activation by CD26 antigen is independent of dipeptidyl peptidase IV activity (1997) (2)
The role of the adenovirus E1a region in transformation and oncogenesis (1986) (2)
Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein. (2005) (1)
Latex fetuin spheres as probes for influenza virus neuraminidase in productively and abortively infected cells (2005) (1)
Rel Proteins and Their Inhibitors: A Balancing Act (1997) (1)
[The rel/NF-kappa B family of transcription factors: a novel mechanism to control gene expression]. (1992) (1)
Vertegaal , mature proteins and have sequence homology within the (2013) (0)
Isotype Switching and Cytokine Synthesis Precursor Subspecies and Enhanced Ig -Deficient Mice: Reduction of One T Cell e B k I (1999) (0)
NF-кB in Genetic Disorders (2003) (0)
Correction (2004) (0)
Complex Regulation of MHC Class I Expression: Constitutive and Modulated Patterns of Expression (1989) (0)
Cooperatively between an upstream TATA-like sequence and a CAA repeated element mediates E1A-dependent negative repression of the H-2Kb class I gene. (1995) (0)
and response to inducers of NF-kappa B activity . degradation of MAD 3 / I kappa B alpha in Nand C-terminal sequences control (1995) (0)
[Human pathologies associated with NF-kappaB defects]. (2004) (0)
DDH192 1763..1773 (2004) (0)
NF-_B and Associated Human Genetic Pathologies (2006) (0)
ThehumanJKrecombination signal sequence binding protein (RBP-JK) targets theEpstein-Barr virus EBNA2protein toitsDNA responsive elements (1994) (0)

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What Schools Are Affiliated With Alain Israël?

Alain Israël is affiliated with the following schools:

University of Oxford

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Published Works

What Schools Are Affiliated With Alain Israël?

Alain Israël's AcademicInfluence.com Rankings