Alain R. Thierry
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Mathematics Computer Science
Alain R. Thierry's Degrees
- PhD Computer Science Université Paris Cité
- Masters Computer Science Université Paris Cité
- Bachelors Mathematics Université Paris Cité
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Why Is Alain R. Thierry Influential?
(Suggest an Edit or Addition)According to Wikipedia, Alain Thierry is a French geneticist and cancer researcher. He specializes in the clinical applications of circulating DNA analysis, notably in cancer care management. He is currently Director of Research at the INSERM’s Cancer Research Institute in Montpellier, France.
Alain R. Thierry's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA (2014) (567)
- Origins, structures, and functions of circulating DNA in oncology (2016) (504)
- Circulating cell free DNA: Preanalytical considerations. (2013) (453)
- High Fragmentation Characterizes Tumour-Derived Circulating DNA (2011) (441)
- Nomenclature for synthetic gene delivery systems. (1997) (438)
- Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts (2010) (258)
- Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone (1995) (234)
- Multi‐marker analysis of circulating cell‐free DNA toward personalized medicine for colorectal cancer (2014) (186)
- Blood contains circulating cell‐free respiratory competent mitochondria (2020) (177)
- Intracellular availability of unmodified, phosphorothioated and liposomally encapsulated oligodeoxynucleotides for antisense activity. (1992) (173)
- Endosome trapping limits the efficiency of splicing correction by PNA-oligolysine conjugates. (2006) (149)
- Circulating Cell-Free DNA from Colorectal Cancer Patients May Reveal High KRAS or BRAF Mutation Load. (2013) (145)
- Circulating DNA as a Strong Multimarker Prognostic Tool for Metastatic Colorectal Cancer Patient Management Care (2016) (136)
- Guidelines for the Preanalytical Conditions for Analyzing Circulating Cell-Free DNA. (2019) (114)
- Quantifying circulating cell-free DNA in humans (2019) (113)
- Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells. (1994) (112)
- Modulation of doxorubicin resistance in multidrug‐resistant cells by liposomes (1993) (103)
- Overcoming multidrug resistance in human tumor cells using free and liposomally encapsulated antisense oligodeoxynucleotides. (1993) (97)
- Clinical utility of circulating DNA analysis for rapid detection of actionable mutations to select metastatic colorectal patients for anti-EGFR treatment (2017) (90)
- The importance of examining the proportion of circulating DNA originating from tumor, microenvironment and normal cells in colorectal cancer patients (2012) (85)
- Cellular uptake and intracellular fate of antisense oligonucleotides. (2003) (81)
- Inhibition of DDR1‐BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer (2018) (76)
- Physico-Chemical Characteristics of Lipoplexes Influence Cell Uptake Mechanisms and Transfection Efficacy (2009) (75)
- Neutrophil Extracellular Traps and By-Products Play a Key Role in COVID-19: Pathogenesis, Risk Factors, and Therapy (2020) (72)
- DNA studies using atomic force microscopy: capabilities for measurement of short DNA fragments (2015) (65)
- New insights into structural features and optimal detection of circulating tumor DNA determined by single-strand DNA analysis (2018) (64)
- Circulating DNA Demonstrates Convergent Evolution and Common Resistance Mechanisms during Treatment of Colorectal Cancer (2017) (63)
- Effect of liposomes on P-glycoprotein function in multidrug resistant cells. (1992) (61)
- Recent advances in circulating nucleic acids in oncology. (2019) (56)
- DNA packing in stable lipid complexes designed for gene transfer imitates DNA compaction in bacteriophage. (1999) (54)
- Radiotoxicity of iodine-125-labeled oligodeoxyribonucleotides in mammalian cells. (1998) (45)
- Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer (2017) (39)
- Sensitization of multidrug-resistant colon cancer cells to doxorubicin encapsulated in liposomes (2004) (38)
- Anti-protease Treatments Targeting Plasmin(ogen) and Neutrophil Elastase May Be Beneficial in Fighting COVID-19 (2020) (37)
- Expression of the human multidrug resistance and glucocerebrosidase cDNAs from adeno-associated vectors: efficient promoter activity of AAV sequences and in vivo delivery via liposomes. (1996) (37)
- Non-invasive pre-implantation genetic diagnosis of X-linked disorders. (2014) (35)
- Inhibition of PAI-1 expression in breast cancer carcinoma cells by siRNA at nanomolar range. (2007) (33)
- Comparison of basic peptides- and lipid-based strategies for the delivery of splice correcting oligonucleotides. (2006) (33)
- Characterization of a Synthetic Anionic Vector for Oligonucleotide Delivery Using in Vivo Whole Body Dynamic Imaging (2002) (32)
- Liposomal delivery as a new approach to transport antisense oligonucleotides. (1992) (31)
- Modulation of multidrug resistance in Chinese hamster cells by liposome-encapsulated doxorubicin. (1989) (31)
- Switching on transgene expression by correcting aberrant splicing using multi‐targeting steric‐blocking oligonucleotides (2007) (30)
- Lipoplex and peptide-based strategies for the delivery of steric-block oligonucleotides. (2007) (30)
- Circulating nuclear DNA structural features, origins, and complete size profile revealed by fragmentomics (2021) (29)
- SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure. (2020) (29)
- Specific subcellular localization of siRNAs delivered by lipoplex in MCF-7 breast cancer cells. (2007) (28)
- Enhanced antisense inhibition of human immunodeficiency virus type 1 in cell cultures by DLS delivery system. (1997) (26)
- BioNetCAD: design, simulation and experimental validation of synthetic biochemical networks (2010) (26)
- Towards systematic nomenclature for cell-free DNA (2020) (25)
- Delivery of oligoribonucleotides to human hepatoma cells using cationic lipid particles conjugated to ferric protoporphyrin IX (heme). (1997) (23)
- Lipoplex nanostructures reveal a general self-organization of nucleic acids. (2009) (20)
- Host/genetic factors associated with COVID-19 call for precision medicine (2020) (18)
- NETs By-products and Extracellular DNA May Play a Key Role in COVID-19 Pathogenesis: Incidence on Patient Monitoring and Therapy (2020) (18)
- Computing with bacterial constituents, cells and populations: from bioputing to bactoputing (2011) (18)
- Clinical relevance of liquid biopsy for cancer screening (2018) (18)
- Association of COVID-19 Lockdown With the Tumor Burden in Patients With Newly Diagnosed Metastatic Colorectal Cancer (2021) (17)
- Cytotoxicity assessment, inflammatory properties, and cellular uptake of Neutraplex lipid-based nanoparticles in THP-1 monocyte-derived macrophages (2017) (15)
- Cationic liposomes/lipids for oligonucleotide delivery: application to the inhibition of tumorigenicity of Kaposi's sarcoma by vascular endothelial growth factor antisense oligodeoxynucleotides. (2004) (15)
- Influence of lipoplex surface charge on siRNA delivery: application to the in vitro downregulation of CXCR4 HIV-1 co-receptor (2013) (14)
- Liposomal Delivery of Antisense Oligodeoxynucleotides. (1992) (14)
- Machine Learning‐Assisted Evaluation of Circulating DNA Quantitative Analysis for Cancer Screening (2020) (14)
- Lipid-based delivery of combinations of antisense oligodeoxynucleotides for the in vitro inhibition of HIV-1 replication (2001) (14)
- A Targeted Q-PCR-Based Method for Point Mutation Testing by Analyzing Circulating DNA for Cancer Management Care. (2016) (14)
- Does the newly observed inflammatory syndrome in children demonstrate a link between uncontrolled neutrophil extracellular traps formation and COVID-19? (2020) (13)
- Hypoxia differently modulates the release of mitochondrial and nuclear DNA (2020) (12)
- Guidelines for pre-analytical conditions for assessing the methylation of circulating cell-free DNA (2021) (12)
- Toward high yield synthesis of peptide-oligonucleotide chimera through a disulfide bridge: a simplified method for oligonucleotide activation. (2005) (12)
- How did Metabolism and Genetic Replication Get Married? (2012) (11)
- Optimization of Lipoplex Formulations for Intravenous Gene Delivery (1997) (11)
- Is antisense an appropriate nomenclature or design for oligodeoxynucleotides aimed at the inhibition of HIV-1 replication? (2008) (10)
- A new procedure for the preparation of liposomal doxorubicin: biological activity in multidrug-resistant tumor cells (2004) (9)
- Pre-analytical Requirements for Analyzing Nucleic Acids from Blood (2015) (9)
- Association of neutrophil extracellular traps with the production of circulating DNA in patients with colorectal cancer (2022) (8)
- The Mimic Chain Reaction (2012) (7)
- Liposomal delivery of antisense oligodeoxynucleotides. Application to the inhibition of the multidrug resistance in cancer cells. (1992) (7)
- Monitoring levels of circulating cell‐free DNA in patients with metastatic colorectal cancer as a potential biomarker of responses to regorafenib treatment (2021) (7)
- Kaposi's sarcoma in pregnant women (1995) (7)
- Persistence of neutrophil extracellular traps and anticardiolipin auto‐antibodies in post‐acute phase COVID‐19 patients (2022) (6)
- Tat-Derived Cell-Penetrating Peptides: Discovery, Mechanism of Cell Uptake, and Applications to the Delivery of Oligonucleotides (2006) (5)
- [Liquid biopsy: a possible approach for cancer screening]. (2018) (5)
- UCGI 28 Panirinox: A randomized phase II study assessing Panitumumab + FOLFIRINOX or mFOLFOX6 in RAS and BRAF wild type metastatic colorectal cancer patients (mCRC) selected from circulating DNA analysis. (2018) (4)
- A Step Closer to Cancer Screening by Blood Test. (2018) (4)
- Circulating DNA analysis and concordance with tumor section analysis in the detection of KRAS and BRAF point mutations from metastatic colorectal cancer. (2012) (4)
- From bioputing to bactoputing: computing with bacteria (2008) (3)
- Detection of Genetic Alterations by Nucleic Acid Analysis: Use of PCR and Mass Spectroscopy-Based Methods (2015) (3)
- Circulating DNA fragmentomics and cancer screening (2023) (3)
- SARS-CoV-2 and Implantation Window: Gene Expression Mapping of Human Endometrium and Preimplantation Embryo (2021) (3)
- Plasma derived cell-free mitochondrial DNA originates mainly from circulating cell-free mitochondria (2021) (2)
- Origins, structures, and functions of circulating DNA in oncology (2016) (2)
- Towards a screening test for cancer by circulating DNA analysis. (2019) (2)
- DNA Supramolecular Self Assemblies as a Biomimetic Complex System (2006) (2)
- L06.06PERSONALIZED MEDICINE BY ANALYZING CIRCULATING DNA: APPLICATION TO THE MANAGEMENT CARE OF COLORECTAL CANCER PATIENTS (2013) (2)
- Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA (2022) (2)
- Clinical Evaluation of Liposome Encapsulated Doxorubicin and the Modulation of Multidrug Resistance in Cancer Cells (1994) (1)
- Association of the Neutrophil Extracellular Traps Formation With the Production of Circulating Cell-Free DNA and Anti-Cardiolipin Autoantibody in Patients With a Metastatic Colorectal Cancer (2021) (1)
- Progress in antisense research and development. (1993) (1)
- Circulating DNA and cancer (2015) (1)
- Abstract 2632: Clinical validation of circulating DNA analysis for the detection of point mutations and of the longitudinal metastatic colorectal patient follow up for detecting emergence of resistance to targeted therapy (2016) (1)
- Modelling of complex biological systems in the context of genomics: an account of a multidisciplinary thematic seminar held in Montpellier (France) in April 2005 (2006) (1)
- Circulating DNA as a strong multimarker prognostic tool in metastatic colorectal cancer patients. (2014) (1)
- Abstract P11: The elevated level of the main markers of neutrophil extracellular traps in metastatic colorectal cancer plasma highlights the enhanced risk of severe forms of COVID-19 in cancer patients (2021) (1)
- A rapid microwell fluorescence immunoassay for cellular protein detection (2008) (1)
- Circulating Cell-Free DNA from Colorectal Cancer Patients May Reveal High KRAS or BRAF (2013) (1)
- Non-invasive test for embryo competent selection by quantification of cell-free nucleic acids in embryo culture micro drop (2014) (1)
- Academia Meets Industry (2003) (1)
- Mechanical signatures of human colon cancers (2022) (1)
- New insights into structural features and optimal detection of circulating tumor DNA determined by single-strand DNA analysis (2018) (0)
- Cryotreatment as a simple method for cell preparation in autologous tumor cell-based vaccination. (2010) (0)
- Abstract 2924: Circulating DNA demonstrates convergent evolution and common resistance mechanisms during treatment of colorectal cancer (2017) (0)
- Technology & tools development (2012) (0)
- Abstract LB-78: Detection of circulating cell-free DNA is enhanced by targeting short fragments: high concordance of theKRASandBRAFmutation status from plasma analysis, with tumor-tissue analysis in colorectal cancer.. (2013) (0)
- Circulating DNA and miRNA Isolation (2015) (0)
- Ultra structure of lipid‐DNA complexes: Influence on their stability andefficacy for in vivo gene transfer (1999) (0)
- P3.12 Circulating Dna Analysis in The Era of Personalized Cancer Medicine: Application to Kras/Braf Point Mutations Detection in Colorectal Cancer (2012) (0)
- How did Metabolism and Genetic Replication Get Married? (2012) (0)
- P14 07 MP – USE OF ANTISENSE OLIGONUCLEOTIDES TO POLY(ADP-RIBOSE)POLYMERASE TO MODULATE THE CELLULAR RADIATION RESPONSE (1991) (0)
- Liposomes as a Delivery System for Antisense and Ribozyme Compounds (2017) (0)
- Reply to Comment on: ‘Hypoxia differently modulates the release of mitochondrial and nuclear DNA’ (2021) (0)
- The tumor burden of metastatic colorectal cancer patients at initial diagnosis, pre- versus post-Covid-19 lockdown (2021) (0)
- Hypoxia differently modulates the release of mitochondrial and nuclear DNA (2020) (0)
- Quantifying circulating cell-free DNA in humans (2019) (0)
- Quantifying circulating cell-free DNA as clinical biomarker. (2018) (0)
- A straightforward method to quantify circulating mRNAs as biomarkers of colorectal cancer (2023) (0)
- Towards a screening test for cancer by circulating DNA analysis (2019) (0)
- Blood transfusion and the presence of biological structures in the circulation. (2022) (0)
- Comparison of the structures and topologies of plasma extracted circulating nuclear and mitochondrial cell-free DNA (2023) (0)
- A method for cell transfection with liposomal-encapsulated nucleic acids (1996) (0)
- The anti-leukemic drug nilotinib inhibits metastatic properties of colorectal cancer cells by targeting the receptor tyrosine kinase DDR1 (2016) (0)
- Guidelines for pre-analytical conditions for assessing the methylation of circulating cell-free DNA (2021) (0)
- Modelling of biological complex systems in the context of genomics. An account of a multidisciplinary thematic seminar held in Montpellier (France) in April 2005 (2006) (0)
- Method of preparing a chemical structure having partitioned capable of generating a fluorescence spectrum and its specific applications (2010) (0)
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