Alain Townsend
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Professor of Molecular Immunology
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Alain Townsend's Degrees
- Bachelors Biology University of Manchester
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(Suggest an Edit or Addition)According to Wikipedia, Alain Townsend is a Professor of Medicine in the Weatherall Institute of Molecular Medicine at Oxford University. His laboratory studies virology, mainly influenza, but more recently ebola. After graduating from St Mary's Hospital, London, he went to the National Institute for Medical Research to study immunology. He received his PhD in 1984, supervised by Brigitte Askonas.
Alain Townsend's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides (1986) (1752)
- Antigen recognition by class I-restricted T lymphocytes. (1989) (1202)
- Association of class I major histocompatibility heavy and light chains induced by viral peptides (1989) (976)
- Empty MHC class I molecules come out in the cold (1990) (946)
- Cytotoxic T cells recognize fragments of the influenza nucleoprotein (1985) (676)
- Molecular analysis of the association of HLA-B53 and resistance to severe malaria (1992) (665)
- SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses (2022) (529)
- Assembly of MHC class I molecules analyzed in vitro (1990) (471)
- HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides (1988) (459)
- Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. (2008) (446)
- Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2 (1987) (430)
- Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex (1992) (417)
- Presentation of viral antigen controlled by a gene in the major histocompatibility complex (1990) (396)
- Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 (2020) (383)
- Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen (1988) (359)
- Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter (1991) (352)
- Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer (1992) (342)
- Hepcidin regulation by innate immune and infectious stimuli. (2011) (262)
- Autophagy is a critical regulator of memory CD8+ T cell formation (2014) (257)
- Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin. (2005) (253)
- Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence (1986) (243)
- Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient (2020) (243)
- The antigenic anatomy of SARS-CoV-2 receptor binding domain (2021) (239)
- Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi (1992) (218)
- Positive and Negative Selection in Transgenic Mice Expressing a T-Cell Receptor Specific for Influenza Nucleoprotein and Endogenous Superantigen (1993) (214)
- Peptide-induced conformational change of the class I heavy chain (1991) (213)
- In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations. (2005) (204)
- Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum (1995) (191)
- Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike (2020) (190)
- The influenza A virus nucleoprotein gene controls the induction of both subtype specific and cross-reactive cytotoxic T cells (1984) (186)
- Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike (2020) (182)
- Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice. (1992) (165)
- Use of synthetic peptides of influenza nucleoprotein to define epitopes recognized by class I-restricted cytotoxic T lymphocytes (1987) (158)
- Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection (2018) (148)
- A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses (2020) (148)
- Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity. (1999) (131)
- The hemochromatosis protein HFE inhibits iron export from macrophages (2002) (129)
- The transporters associated with antigen presentation. (1993) (127)
- Localisation of proteins of iron metabolism in the human placenta and liver (2006) (112)
- Focused antibody response to influenza linked to antigenic drift. (2015) (109)
- Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors (2010) (97)
- Loss of major histocompatibility complex-encoded transporter associated with antigen presentation (TAP) in colorectal cancer. (1994) (95)
- HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis. (2005) (93)
- Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern (2021) (93)
- Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload (2002) (83)
- Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses (2021) (80)
- Expression of marine H–2Kb histocompatibility antigen in cells transformed with cloned H–2 genes (1982) (77)
- Influenza A specific cytotoxic T-cell clones that do not recognize viral glycoproteins (1982) (77)
- Regulation of growth differentiation factor 15 expression by intracellular iron. (2009) (76)
- Fast association rates suggest a conformational change in the MHC class I molecule H-2Db upon peptide binding. (1998) (76)
- Resistance to H-2-restricted but not to allo-H2-specific graft and cytotoxic T lymphocyte responses in lymphoma mutant. (1990) (69)
- A method to quantify binding of unlabeled peptides to class I MHC molecules and detect their allele specificity. (1993) (69)
- Different types of allospecific CTL clones identified by their ability to recognize peptide loading‐defective target cells (1991) (67)
- A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes (1989) (53)
- Specificity of cytotoxic T lymphocytes stimulated with influenza virus. Studies in mice and humans. (1985) (52)
- A mutant cell in which association of class I heavy and light chains is induced by viral peptides. (1989) (51)
- Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans. (2019) (51)
- Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models (2022) (48)
- Expression of murine H-2Kb histocompatibility antigen in cells transformed with cloned H-2 genes. (1982) (47)
- Recognition of influenza A virus nucleoprotein by an H-2-restricted cytotoxic T-cell clone. (1984) (47)
- Source of unique tumour antigens (1994) (44)
- Vaccine-induced immunity provides more robust heterotypic immunity than natural infection to emerging SARS-CoV-2 variants of concern. (2021) (43)
- CD8 independence and specificity of cytotoxic T lymphocytes restricted by HLA-Aw68. 1 (1991) (41)
- Naturally processed peptides (1990) (41)
- Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection (2020) (40)
- Breadth and function of antibody response to acute SARS-CoV-2 infection in humans (2021) (38)
- Structure–function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans (2018) (38)
- Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection (2018) (38)
- Tolerance in TCR/Cognate Antigen Double-Transgenic Mice Mediated by Incomplete Thymic Deletion and Peripheral Receptor Downregulation (1996) (37)
- Influenza-specific cytotoxic T-cell recognition is inhibited by peptides unrelated in both sequence and MHC restriction. (1989) (35)
- Mouse H-2k-restricted cytotoxic T cells recognize antigenic determinants in both the HA1 and HA2 subunits of the influenza A/PR/8/34 hemagglutinin (1987) (33)
- Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation (2020) (32)
- Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses (2021) (30)
- Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs. (2018) (30)
- Murine Cytotoxic T Lymphocytes Recognize an Epitope in an EBNA-1 Fragment, but Fail to Lyse EBNA-1–expressing Mouse Cells (1998) (29)
- Recognition of influenza virus proteins by cytotoxic T lymphocytes (1987) (28)
- Plasmablast-derived antibody response to acute SARS-CoV-2 infection in humans (2020) (28)
- Ferroportin: lack of evidence for multimers. (2008) (27)
- Viral recognition by influenza A virus cross‐reactive cytotoxic T (Tc) cells: The proportion of Tc cells that recognize nucleoprotein varies between individual mice (1986) (25)
- Those images that yet fresh images beget (1987) (22)
- The structure and function of HFE. (2000) (21)
- Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity (2021) (20)
- Vaccinia virus serpins B13R and B22R do not inhibit antigen presentation to class I-restricted cytotoxic T lymphocytes. (1995) (20)
- Recognition of influenza virus proteins by cytotoxic T lymphocytes. (1989) (20)
- Structure and expression of the human globin genes and murine histocompatibility antigen genes. (1983) (20)
- Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell–cell fusion (2020) (19)
- Two doses of SARS-CoV-2 vaccination induce more robust immune responses to emerging SARS-CoV-2 variants of concern than does natural infection. (2021) (19)
- Short peptides assist the folding of free class I heavy chains in solution (1992) (18)
- The T cell receptor from an influenza-A specific murine CTL clone. (1989) (18)
- Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans (2019) (17)
- Characterization of Influenza Virus Pseudotyped with Ebolavirus Glycoprotein (2017) (17)
- Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms (2020) (15)
- Molecular diagnosis of the first ferroportin mutation (C326Y) in the far east causing a dominant form of inherited iron overload (2004) (14)
- Characterization of neutralizing epitopes in antigenic site B of recently circulating influenza A(H3N2) viruses (2018) (12)
- A new presentation pathway? (1992) (10)
- The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. 1986. (2006) (10)
- Antibody and T-cell responses to a single dose of the AZD1222/Covishield vaccine in previously SARS-CoV-2 infected and naive health care workers in Sri Lanka (2021) (10)
- Molecules at work on the T-cell surface. (1985) (9)
- Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 (2020) (9)
- Specific recognition of influenza virus polymerase protein (PB1) by a murine cytotoxic T-cell clone. (1987) (8)
- In vitro binding of HFE to the cation-independent mannose-6 phosphate receptor. (2009) (8)
- Specificity of Cytotoxic T Lymphocytes Stimulated with Influenza Virus (Part 2 of 2) (1985) (7)
- Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus (2020) (7)
- Lung-targeting lentiviral vector for passive immunisation against influenza (2020) (6)
- Recognition of Db and Kb gene products by influenza-specific cytotoxic T cells (2004) (6)
- Recognition of Z-RNA by ADAR1 limits interferon responses (2020) (5)
- Antigen presentation. Naturally processed peptides. (1990) (5)
- A single cycle influenza virus coated in H7 haemagglutinin generates neutralizing antibody responses to haemagglutinin and neuraminidase glycoproteins and protection from heterotypic challenge. (2019) (5)
- MHC protein structure. Those images that yet fresh images beget. (1987) (4)
- Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans (2020) (4)
- Antigen processing. A new presentation pathway? (1992) (4)
- Recognition of the Viral Nucleoprotein by Influenza a Specific Cytotoxic T Cells (1985) (3)
- Natural and vaccine-induced antibody and cellular responses against emerging SARS-CoV-2 variants of concern (2021) (3)
- Structure–function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans (2018) (3)
- Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2 (2022) (3)
- Specificity of Cytotoxic T Lymphocytes Stimulated with Influenza Virus (Part 1 of 2) (1985) (3)
- cGAMP loading enhances the immunogenicity of VLP vaccines (2020) (2)
- A novel biparatopic antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy (2020) (2)
- Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2 (2023) (2)
- Broadly inhibiting anti-neuraminidase monoclonal antibodies induced by 1 trivalent influenza vaccine and H7N9 infection in humans 2 (2019) (2)
- Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 (2020) (2)
- Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models (2022) (2)
- Antigen presentation and the association of class-I molecules. (1991) (2)
- Diversity in the interaction of influenza-A-specific cytotoxic T cells with H-2Kb mutant targets (2004) (2)
- Human monoclonal antibodies from convalescent H7N9 patients in China and Taiwan (2014) (2)
- The Kinetics of Association of Peptides with MHC Class 1 Molecules (1993) (2)
- Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. 1990. (2008) (1)
- Structure and expression of class I genes of the mouse major histocompatibility complex. (1983) (1)
- Antigenic Characterization of Human Monoclonal Antibodies for Therapeutic Use against H7N9 Avian Influenza Virus (2022) (1)
- Low Dose Pig Anti-Influenza Virus Monoclonal Antibodies Reduce Lung Pathology but Do Not Prevent Virus Shedding (2021) (1)
- Correction to bastin et al (1998) (2003) (1)
- Pillars article: Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 1989. 340: 443-448. (2007) (1)
- Author response: Autophagy is a critical regulator of memory CD8+ T cell formation (2014) (1)
- Correction: Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport (European Journal of Immunology (1995) 25 (561-562)) (1995) (0)
- Lentiviral-Mediated Expression of Monoclonal Antibodies in the Lung to Protect Against Influenza (2020) (0)
- Lack of truncated IFITM3 transcripts in cells homozygous for the rs12252-C variant infection (2017) (0)
- Vaceinia virus serpins B 13 R and B 22 R do not inhibit antigen presentation to class I-restricted cytotoxic T lymphocytes (2007) (0)
- Development of Recombinant Adeno-Associated Viral Vector (rAAV) for Passive Immunisation Against Ebola (2017) (0)
- Upregulation of duodenal protein expression of divalent metal transporter 1 protein in untreated coeliac disease may be due to a switch to a more mature mucosal epithelial phenotype (2003) (0)
- A single cycle influenza virus coated in H7 hemagglutinin provides heterotypic protection and neutralising antibody responses to both glycoproteins (2017) (0)
- I Genes of the Mouse Major Histocompatibility Complex (2005) (0)
- Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells (2019) (0)
- Lung-targeted lentiviral vector mediates passive immunisation against influenza (2018) (0)
- Cross-Neutralisation of Novel Bombali Virus by Ebola Virus Antibodies and Convalescent Plasma Using an Optimised Pseudotype-Based Neutralisation Assay (2021) (0)
- MHC CLASS-I EXPRESSION IN TRANSPLANTATION TOLERANCE AND PEPTIDE PRESENTATION TO CTL - A MUTANT-CELL THAT FAILS TO PRESENT INTERNALLY DERIVED H-2 RESTRICTED ANTIGENS BUT REMAINS SENSITIVE TO ALLO H-2 SPECIFIC RESPONSES (1989) (0)
- Molecular Cloning of H-2 Class I Genes in the H-2b Haplotype (1984) (0)
- Construction of chimaeric haemagglutinin genes in order to investigate determinants for recognition by murine cytotoxic T cells (1985) (0)
- Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology (2023) (0)
- Recognition of Nucleoprotein by Influenza Specific CTL (1986) (0)
- 8 – Recognition of Influenza Antigens by Class I-Restricted Cytotoxic T Lymphocytes (1990) (0)
- DO VACCINIA VIRUS-ENCODED SERPINS INHIBIT ANTIGEN PRESENTATION TO CLASS I-RESTRICTED CTL (1993) (0)
- Crystal structure of Ebolavirus glycoprotein in complex with thioridazine (2018) (0)
- 431. Lung Antibody Factory for Passive Immunisation Against Influenza (2016) (0)
- HEPCIDIN REGULATION DURING ACUTE INFECTIONS (2013) (0)
- Correction: Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans (2021) (0)
- A single cycle influenza virus coated in H7 hemagglutinin generates neutralising antibody responses to HA and NA glycoproteins and protection from heterotypic challenge (2019) (0)
- Role of HFE in iron metabolism, hereditary haemochomatosis, anaemia of chronic disease, and secondary iron overload (vol 359, pg 786, 2002) (2002) (0)
- Studies on the nature and mechanism of influenza antigen recognition by murine cytotoxic T cells (1988) (0)
- Correction: Breadth and function of antibody response to acute SARS-CoV-2 infection in humans (2021) (0)
- STRUCTURE AND EXPRESSION OF GLOBIN AND H-2 GENES (1982) (0)
- Correction (2020) (0)
- Deficient peptide binding by MHC class I due to prolonged interaction with calnexin in a mutant cell line (1999) (0)
- A METHOD TO MEASURE MHC CLASS-I-PEPTIDE INTERACTIONS AT THE CELL-SURFACE (1990) (0)
- Use of Pseudotyped, Replication-Deficient Influenza to Facilitate Testing of Gene Delivery Strategies for Treatment of Highly Infectious Diseases (2018) (0)
- HEPCIDIN REGULATION IN MALARIA INFECTION (2013) (0)
- Binding of acetylcholine receptor alpha subunit peptides to MHC class I molecules (1991) (0)
- Analysis of HIV-1 gag Peptides with a Quantitative Peptide-Dependent Class I Assembly Assay (1992) (0)
- Binding of acetylcholine receptor α-subunit peptides to HLA-A2 (1991) (0)
- Antigenic characterisation of human monoclonal antibodies for therapeutic use against H7N9 avian influenza virus (2022) (0)
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