Alain Sarasin

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Alain Sarasin is affiliated with the following schools: University of Oslo, McGill University, University of Sussex, Paris-Saclay University, ETH Zurich, KU Leuven, University of Geneva

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Alain Sarasin

Computer Science

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#1256

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Machine Learning

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#2339

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Artificial Intelligence

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Computer Science

Alain Sarasin's Degrees

Masters Computer Science University of Geneva
Bachelors Computer Science University of Geneva

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Alain Sarasin's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Gene expression profiling of primary cutaneous melanoma and clinical outcome. (2006) (481)
Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells. (2002) (349)
Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients. (1993) (274)
UV Irradiation Triggers Ubiquitin-Dependent Degradation of p21WAF1 to Promote DNA Repair (2003) (271)
Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene. (1997) (270)
Trichothiodystrophy: update on the sulfur-deficient brittle hair syndromes. (2001) (268)
TP53 mutations in human skin cancers (2003) (266)
Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. (2008) (251)
ERCC1 Codon 118 Polymorphism Is a Predictive Factor for the Tumor Response to Oxaliplatin/5-Fluorouracil Combination Chemotherapy in Patients with Advanced Colorectal Cancer (2005) (251)
High expression of DNA repair pathways is associated with metastasis in melanoma patients (2008) (248)
RETRACTED: Transcription-Coupled Repair of 8-oxoGuanine Requirement for XPG, TFIIH, and CSB and Implications for Cockayne Syndrome (2000) (247)
ERCC2/XPD gene polymorphisms and cancer risk. (2002) (229)
The molecular pathways of ultraviolet-induced carcinogenesis. (1999) (209)
BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells. (2000) (209)
Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes. (1999) (203)
XPD Mutations Prevent TFIIH-Dependent Transactivation by Nuclear Receptors and Phosphorylation of RARα (2002) (200)
Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome (2010) (193)
ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review. (2005) (190)
Transcription-Coupled Repair of 8-oxoguanine: Requirement for XPG, TFIIH, and CSB and Implications for Cockayne Syndrome (2005) (187)
DNA repair: from molecular mechanism to human disease. (2006) (187)
Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients (2002) (167)
The specificity of p53 mutation spectra in sunlight induced human cancers. (1995) (165)
Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743 (2007) (157)
Variability in nucleotide excision repair and cancer risk: a review. (2000) (153)
Cancer-prone hereditary diseases with DNA processing abnormalities (1986) (148)
The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless mice. (1997) (147)
An overview of the mechanisms of mutagenesis and carcinogenesis. (2003) (146)
The role of UV induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors. (2005) (145)
Carcinogens enhance survival of UV-irradiated simian virus 40 in treated monkey kidney cells: induction of a recovery pathway? (1978) (141)
Transcription coupled repair of 8-oxoguanine in murine cells: the ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences. (2000) (141)
Role of DNA Polymerase η in the UV Mutation Spectrum in Human Cells* (2003) (133)
Skin Tumors Induced by Sorafenib; Paradoxic RAS–RAF Pathway Activation and Oncogenic Mutations of HRAS, TP53, and TGFBR1 (2011) (132)
DNA Polymerase η Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch Recombination (2004) (129)
High levels of patched gene mutations in basal-cell carcinomas from patients with xeroderma pigmentosum. (1999) (128)
Mutagenicity of a unique 8-oxoguanine in a human Ha-ras sequence in mammalian cells. (1995) (123)
Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability (2007) (116)
Cell survival and shuttle vector mutagenesis induced by ultraviolet A and ultraviolet B radiation in a human cell line. (1996) (116)
A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage (2009) (114)
Defects in the DNA repair and transcription gene ERCC2(XPD) in trichothiodystrophy. (1996) (111)
Genetic heterogeneity of the excision repair defect associated with trichothiodystrophy. (1993) (108)
Can we predict solar ultraviolet radiation as the causal event in human tumours by analysing the mutation spectra of the p53 gene? (1994) (106)
High mutation frequency in ras genes of skin tumors isolated from DNA repair deficient xeroderma pigmentosum patients. (1993) (105)
Human DNA polymerase iota protects cells against oxidative stress (2008) (104)
Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene. (2001) (103)
Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line. (2008) (102)
Induction of an error-prone mode of DNA repair in UV-irradiated monkey kidney cells. (1980) (102)
DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract (2004) (93)
p53 mutations in skin and internal tumors of xeroderma pigmentosum patients belonging to the complementation group C. (1998) (90)
Transmembrane diffusion of gemcitabine by a nanoparticulate squalenoyl prodrug: an original drug delivery pathway. (2010) (90)
The genetics of the hereditary xeroderma pigmentosum syndrome. (2002) (88)
Overexpression of DNA repair genes is associated with metastasis: a new hypothesis. (2008) (88)
A prevalent mutation with founder effect in xeroderma pigmentosum group C from north Africa. (2010) (84)
Reduced XPC DNA repair gene mRNA levels in clinically normal parents of xeroderma pigmentosum patients. (2006) (84)
Targeted Gene Therapy of Xeroderma Pigmentosum Cells Using Meganuclease and TALEN™ (2013) (84)
Mutagenicity of a unique apurinic/apyrimidinic site in mammalian cells. (1992) (82)
Association between DNA repair-deficiency and high level of p53 mutations in melanoma of Xeroderma pigmentosum. (2001) (82)
The proapoptotic effect of hepatitis B virus HBx protein correlates with its transactivation activity in stably transfected cell lines (1999) (81)
Differential behaviors toward ultraviolet A and B radiation of fibroblasts and keratinocytes from normal and DNA-repair-deficient patients. (1999) (80)
Ocular manifestations in the inherited DNA repair disorders. (2003) (80)
Replication of ultraviolet-irradiated simian virus 40 in monkey kidney cells. (1980) (78)
Viral Probes for DNA Repair (1983) (78)
Clues to epidermal cancer proneness revealed by reconstruction of DNA repair-deficient xeroderma pigmentosum skin in vitro (2001) (78)
ERCC 2 / XPD gene polymorphisms and cancer risk (2002) (77)
Irofulven Cytotoxicity Depends on Transcription-Coupled Nucleotide Excision Repair and Is Correlated with XPG Expression in Solid Tumor Cells (2004) (77)
Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers. (2007) (76)
Mutagenicity of a unique thymine-thymine dimer or thymine-thymine pyrimidine pyrimidone (6-4) photoproduct in mammalian cells. (1996) (75)
CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells. (2008) (73)
Relationship between pyrimidine dimers, 6-4 photoproducts, repair synthesis and cell survival: studies using cells from patients with trichothiodystrophy. (1990) (72)
Deficiency in the catalase activity of xeroderma pigmentosum cell and simian virus 40-transformed human cell extracts. (1986) (71)
Targeted mutagenesis of SV40 DNA induced by UV light (1983) (71)
Prenatal diagnosis in a subset of trichothiodystrophy patients defective in DNA repair (1992) (71)
Prolonged p53 protein accumulation in trichothiodystrophy fibroblasts dependent on unrepaired pyrimidine dimers on the transcribed strands of cellular genes (1997) (69)
UV-specific mutations of the human patched gene in basal cell carcinomas from normal individuals and xeroderma pigmentosum patients. (2000) (69)
Repair and mutagenic potency of 8-oxoG:A and 8-oxoG:C base pairs in mammalian cells. (1998) (69)
New Functional Signatures for Understanding Melanoma Biology from Tumor Cell Lineage-Specific Analysis (2015) (68)
New insights for understanding the transcription-coupled repair pathway. (2007) (67)
Trabectedin and Its C Subunit Modified Analogue PM01183 Attenuate Nucleotide Excision Repair and Show Activity toward Platinum-Resistant Cells (2011) (66)
SOS response in mammalian cells. (1985) (66)
Striking differences in cellular catalase activity between two DNA repair-deficient diseases: xeroderma pigmentosum and trichothiodystrophy. (1992) (66)
Mutation spectrum of heat-induced abasic sites on a single-stranded shuttle vector replicated in mammalian cells. (1992) (66)
DNA ligase in repair and replication in the embryos of rye, Secale cereale (1987) (65)
Cerebro-oculo-facio-skeletal syndrome: three additional cases with CSB mutations, new diagnostic criteria and an approach to investigation (2008) (64)
Association between INK4a-ARF and p53 mutations in skin carcinomas of xeroderma pigmentosum patients. (2000) (64)
The DNA repair genes XPB and XPD defend cells from retroviral infection. (2006) (63)
Deleterious effects of ultraviolet A radiation in human cells. (1997) (61)
Photogenotoxicity of Mammalian Cells: A Review of the Different Assays for In Vitro Testing¶ (2002) (60)
Transcriptional Mutagenesis Induced by 8-Oxoguanine in Mammalian Cells (2009) (59)
Xeroderma pigmentosum: From Symptoms and Genetics to Gene-Based Skin Therapy (2004) (59)
Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome. (2014) (58)
Oxidative stress in cancer prone xeroderma pigmentosum fibroblasts. Real-time and single cell monitoring of superoxide and nitric oxide production with microelectrodes. (2003) (57)
An immortalized xeroderma pigmentosum, group C, cell line which replicates SV40 shuttle vectors. (1987) (57)
Transcription through 8-oxoguanine in DNA repair-proficient and Csb(-)/Ogg1(-) DNA repair-deficient mouse embryonic fibroblasts is dependent upon promoter strength and sequence context. (2007) (57)
Hypothetical role of RNA damage avoidance in preventing human disease. (2005) (57)
Molecular responses to photogenotoxic stress induced by the antibiotic lomefloxacin in human skin cells: from DNA damage to apoptosis. (2003) (57)
Sequence effect on alkali-sensitive sites in UV-irradiated SV40 DNA. (1987) (57)
BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes. (2007) (56)
The comet assay as a repair test for prenatal diagnosis of Xeroderma pigmentosum and trichothiodystrophy. (1997) (56)
The relative expression of mutated XPB genes results in xeroderma pigmentosum/Cockayne's syndrome or trichothiodystrophy cellular phenotypes. (1999) (56)
Significantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patients. (2002) (55)
Preclinical corrective gene transfer in xeroderma pigmentosum human skin stem cells. (2012) (55)
Impaired DNA repair as assessed by the "comet" assay in patients with thyroid tumors after a history of radiation therapy: a preliminary study. (1998) (54)
Repair of DNA in human cells after treatment with activated aflatoxin B1. (1977) (54)
Analysis of skin cancer risk factors in immunosuppressed renal transplant patients shows high levels of UV-specific tandem CC to TT mutations of the p53 gene. (2006) (53)
New clinico‐genetic classification of trichothiodystrophy (2009) (52)
Genetic correction of DNA repair-deficient/cancer-prone xeroderma pigmentosum group C keratinocytes. (2003) (52)
Apurinic sites cause mutations in simian virus 40. (1984) (52)
Development of New EBV-Based Vectors for Stable Expression of Small Interfering RNA to Mimick Human Syndromes: Application to NER Gene Silencing (2005) (52)
Coding properties of a unique apurinic/apyrimidinic site replicated in mammalian cells. (1994) (51)
UVB-induced mutations in human key gatekeeper genes governing signalling pathways and consequences for skin tumourigenesis. (2003) (51)
Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome (2015) (51)
Mutagenic properties of a unique abasic site in mammalian cells. (1990) (50)
Functional Analysis of Novel Sonic Hedgehog Gene Mutations Identified in Basal Cell Carcinomas from Xeroderma Pigmentosum Patients (2004) (50)
Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas (2008) (50)
Activation of the NADPH oxidase in human fibroblasts by mechanical intrusion of a single cell with an ultramicroelectrode. (1997) (49)
Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells (2016) (49)
A microarray to measure repair of damaged plasmids by cell lysates. (2008) (49)
Novel XPG (ERCC5) Mutations Affect DNA Repair and Cell Survival after Ultraviolet but not Oxidative Stress (2013) (48)
Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication (2003) (48)
Fanconi anemia C gene product regulates expression of genes involved in differentiation and inflammation (2004) (48)
Wide clinical variability among 13 new Cockayne syndrome cases confirmed by biochemical assays (2005) (47)
Deletion of 5′ sequences of the CSB gene provides insight into the pathophysiology of Cockayne syndrome (2008) (47)
Effects of XPD mutations on ultraviolet-induced apoptosis in relation to skin cancer-proneness in repair-deficient syndromes. (2001) (46)
A new XPC gene splicing mutation has lead to the highest worldwide prevalence of xeroderma pigmentosum in black Mahori patients. (2011) (46)
Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. (2007) (46)
Antisense insulin-like growth factor I transferred into a rat hepatoma cell line inhibits tumorigenesis by modulating major histocompatibility complex I cell surface expression. (1997) (45)
Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans. (2000) (44)
Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. (2012) (44)
Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma‐prone families or patients (2009) (43)
Differential Repair of the Two Major UV-Induced Photolesions in Trichothiodystrophy Fibroblasts (2004) (42)
Quantitative detection of ultraviolet-specific p53 mutations in normal skin from Japanese patients. (1997) (41)
Effect of the anti-neoplastic drug doxorubicin on XPD-mutated DNA repair-deficient human cells. (2010) (41)
Low catalase activity in xeroderma pigmentosum fibroblasts and SV40-transformed human cell lines is directly related to decreased intracellular levels of the cofactor, NADPH. (1998) (41)
Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (2009) (40)
Induction of apoptosis in rat hepatocarcinoma cells by expression of IGF-I antisense c-DNA. (1998) (40)
Transcriptional profiles of unirradiated or UV-irradiated human cells expressing either the cancer-prone XPB/CS allele or the noncancer-prone XPB/TTD allele (2005) (39)
Amplification of the Inflammatory Cellular Redox State by Human Immunodeficiency Virus Type 1-Immunosuppressive Tat and gp160 Proteins (1999) (39)
A Backup Role of DNA Polymerase κ in Ig Gene Hypermutation Only Takes Place in the Complete Absence of DNA Polymerase η1 (2009) (39)
Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype–phenotype relationships (2007) (39)
Translational step inhibited in vivo by aflatoxin B1 in rat-liver polysomes. (1975) (39)
SINGLET OXYGEN INDUCED DNA DAMAGE AND MUTAGENICITY IN A SINGLE‐STRANDED SV40‐BASED SHUTTLE VECTOR (1992) (38)
Autosomal-recessive SASH1 variants associated with a new genodermatosis with pigmentation defects, palmoplantar keratoderma and skin carcinoma (2014) (37)
Trichothiodystrophy fibroblasts are deficient in the repair of ultraviolet-induced cyclobutane pyrimidine dimers and (6-4)photoproducts. (2004) (37)
Correlation of Phenotype/Genotype in a Cohort of 23 Xeroderma Pigmentosum‐Variant Patients Reveals 12 New Disease‐Causing POLH Mutations (2014) (37)
The genetic basis of xeroderma pigmentosum and trichothiodystrophy syndromes. (1996) (37)
SINGLET MOLECULAR OXYGEN INDUCED MUTAGENICITY IN A MAMMALIAN SV40‐BASED SHUTTLE VECTOR (1990) (36)
Human cancer and DNA repair-deficient diseases. (1997) (36)
Influence of irofulven, a transcription-coupled repair-specific antitumor agent, on RNA polymerase activity, stability and dynamics in living mammalian cells (2008) (36)
Mechanisms of mutagenesis in mammalian cells. Application to human thyroid tumours. (1999) (35)
Mutagenesis in monkey cells of a vector containing a single d(GPG) cis- diamminedichloroplatinum(II) adduct placed on codon 13 of the human H- ras proto-oncogene (1994) (35)
Characteristics of UV-induced mutation spectra in human XP-D/ERCC2 gene-mutated xeroderma pigmentosum and trichothiodystrophy cells. (1995) (35)
Mutation spectra induced by replication of two vicinal oxidative DNA lesions in mammalian cells. (2000) (35)
Molecular analysis of DNA junctions produced by illegitimate recombination in human cells. (1992) (34)
Simian virus 40 (SV40) large T antigen-dependent amplification of an Epstein-Barr virus-SV40 hybrid shuttle vector integrated into the human HeLa cell genome. (1992) (33)
Identification of new RECQL4 mutations in Caucasian Rothmund-Thomson patients and analysis of sensitivity to a wide range of genotoxic agents. (2008) (33)
Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells (2016) (32)
Effect of cell confluence on ultraviolet light apoptotic responses in DNA repair deficient cells. (2003) (32)
Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions. (2012) (31)
p53 mutations in cutaneous lesions induced in the hairless mouse by a solar ultraviolet light simulator (1998) (31)
The nuclear concentration of kin17, a mouse protein that binds to curved DNA, increases during cell proliferation and after UV irradiation. (1998) (31)
DNA damage and gene therapy of xeroderma pigmentosum, a human DNA repair-deficient disease. (2015) (31)
Unexpected extradermatological findings in 31 patients with xeroderma pigmentosum type C (2013) (30)
Germline and somatic mutations of the INK4a-ARF gene in a xeroderma pigmentosum group C patient. (2002) (30)
Cyclobutane pyrimidine dimers are the main mutagenic DNA photoproducts in DNA repair-deficient trichothiodystrophy cells. (1998) (30)
Effects of camptothecin on double-strand break repair by non-homologous end-joining in DNA mismatch repair-deficient human colorectal cancer cell lines (2005) (30)
Recovery of the normal p53 response after UV treatment in DNA repair-deficient fibroblasts by retroviral-mediated correction with the XPD gene. (1998) (30)
Safe selection of genetically manipulated human primary keratinocytes with very high growth potential using CD24. (2007) (30)
Transcription-coupled repair of 8-oxoguanine in human cells and its deficiency in some DNA repair diseases. (2003) (29)
Relationship between posttranslational modification of transaldolase and catalase deficiency in UV-sensitive repair-deficient xeroderma pigmentosum fibroblasts and SV40-transformed human cells. (2001) (28)
Error-prone replication of ultraviolet-irradiated simian virus 40 in carcinogen-treated monkey kidney cells. (1982) (28)
Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype. (2019) (28)
Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer. (2002) (27)
UVSSA and USP7: new players regulating transcription-coupled nucleotide excision repair in human cells (2012) (27)
In vivo effect of aflatoxin B1, on protein synthesis in rat liver (1973) (27)
A genetic cluster of patients with variant xeroderma pigmentosum with two different founder mutations (2017) (26)
Overexpression of matrix metalloproteinase 1 in dermal fibroblasts from DNA repair-deficient/cancer-prone xeroderma pigmentosum group C patients (2008) (26)
Induced reactivation of UV-damaged phage λ in E. coli K12 host cells treated with aflatoxin B1 metabolites (1977) (26)
Ultraviolet A- and singlet oxygen-induced mutation spectra. (2000) (25)
Variants in DNA double‐strand break repair and DNA damage‐response genes and susceptibility to lung and head and neck cancers (2008) (25)
Repair and mutagenesis survey of 8-hydroxyguanine in bacteria and human cells. (1999) (25)
Familial predisposition to TP53/complex karyotype MDS and leukemia in DNA repair-deficient xeroderma pigmentosum. (2019) (24)
Mutation spectrum following transfection of ultraviolet-irradiated single-stranded or double-stranded shuttle vector DNA into monkey cells. (1991) (24)
Restoring DNA repair capacity of cells from three distinct diseases by XPD gene-recombinant adenovirus (2005) (23)
Induction and mutagenesis of prophage λ in Escherichiacoli K12 by metabolites of aflatoxin B1 (1975) (23)
Decrease in catalase activity and loss of the 11p chromosome arm in the course of SV40 transformation of human fibroblasts. (1993) (23)
UV-induced mutations in a shuttle vector replicated in repair deficient trichothiodystrophy cells differ with those in genetically-related cancer prone xeroderma pigmentosum. (1993) (22)
Enhanced mutagenesis of UV-irradiated simian virus 40 occurs in mitomycin C-treated host cells only at a low multiplicity of infection (1986) (22)
Description of a new amplifiable shuttle vector for mutagenesis studies in human cells: application to N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation spectrum. (1992) (22)
Heterogeneity of mammalian DNA ligase detected on activity and DNA sequencing gels. (1984) (22)
Inhibition of in vitro protein synthesis by aflatoxin B1 derivatives (1973) (22)
Respective roles of pyrimidine dimer and pyrimidine (6-4) pyrimidone photoproducts in UV mutagenesis of simian virus 40 DNA in mammalian cells (1989) (22)
Distribution of ultraviolet-induced lesions in simian virus 40 DNA. (1985) (21)
p53 gene mutations in human skin cancers (2002) (21)
DNA repair pathways and human metastatic malignant melanoma. (2010) (21)
The amyloid peptide induces early genotoxic damage in human preneuron NT2. (2001) (20)
Ultraviolet irradiation represses PATCHED gene transcription in human epidermal keratinocytes through an activator protein-1-dependent process. (2004) (20)
A prognostic signature of defective p53‐dependent G1 checkpoint function in melanoma cell lines (2012) (20)
CPD-photolyase adenovirus-mediated gene transfer in normal and DNA-repair-deficient human cells (2004) (20)
UV lesions located on the leading strand inhibit DNA replication but do not inhibit SV40 T-antigen helicase activity. (2000) (20)
Activity gels for analysing DNA processing enzymes (1986) (19)
The consequence of translesional replication of unique UV-induced photoproducts. (1997) (19)
Some mutations in the xeroderma pigmentosum D gene may lead to moderate but significant radiosensitivity associated with a delayed radiation-induced ATM nuclear localization (2019) (19)
SV40-based Escherichia coli shuttle vectors infectious for monkey cells. (1987) (19)
Chromatin and nucleolar changes in Xeroderma pigmentosum cells resemble aging-related nuclear events. (1989) (19)
Comparative study of Epstein-Barr virus and SV40-based shuttle-expression vectors in human repair-deficient cells. (1989) (19)
Establishment of a human cell line for the detection of demethylating agents. (1992) (18)
DNA synthesis blocking lesions induced by singlet oxygen are targeted to deoxyguanosines. (1992) (18)
Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells. (2002) (18)
The key role of UVA‐light induced oxidative stress in human Xeroderma Pigmentosum Variant cells (2019) (18)
Analysis of single-stranded DNA stability and damage-induced strand loss in mammalian cells using SV40-based shuttle vectors. (1989) (18)
Strategies to Analyse Mutagenesis in Mammalian Cells Using Simian Virus 40 or Shuttle Vectors (1987) (18)
Reconstruction of DNA Repair–deficient Xeroderma Pigmentosum Skin In Vitro: A Model to Study Hypersensitivity to UV Light ¶ (2005) (17)
Induced DNA repair processes in eucaryotic cells. (1979) (16)
Enhanced reactivation and mutagenesis after transfection of carcinogen-treated monkey kidney cells with UV-irradiated simian virus 40 (SV40) DNA. (1982) (16)
DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade (2018) (16)
DNA ligase activity in human cell lines from normal donors and Bloom's syndrome patients. (1989) (16)
The NER proteins XPC and CSB, but not ERCC1, regulate the sensitivity to the novel DNA binder S23906: implications for recognition and repair of antitumor alkylators. (2010) (16)
[Genetic instability and cancer]. (1995) (15)
Recovery of normal DNA repair and mutagenesis in trichothiodystrophy cells after transduction of the XPD human gene. (1996) (15)
Trichothiodystrophies : manifestations évolutives (1999) (15)
XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature (2020) (15)
New founder germline mutations of CDKN2A in melanoma‐prone families and multiple primary melanoma development in a patient receiving levodopa treatment (2007) (15)
Molecular analysis of glioma and skin‐tumour alterations in a xeroderma‐pigmentosum child (1999) (15)
Defective transcription/repair factor IIH recruitment to specific UV lesions in trichothiodystrophy syndrome. (2008) (15)
2-(N-acetoxy-N-acetylamino)fluorene mutagenesis in mammalian cells: sequence-specific hot spot. (1986) (15)
DNA damage and mutations induced by arachidonic acid peroxidation. (2003) (15)
Mutagenic fingerprint of ozone in human cells. (2002) (15)
SV40-based shuttle viruses. (1989) (14)
Expression profiling of melanoma cell lines: in search of a progression-related molecular signature. (2007) (14)
Differential Replication of a SingleN-2-Acetylaminofluorene Lesion in the Leading or Lagging Strand DNA in a Human Cell Extract* (1997) (14)
Workshop on processing of DNA damage. (1996) (14)
High recombination rate of an Epstein-Barr virus-simian virus 40 hybrid shuttle vector in human cells (1989) (13)
Retrovirus-mediated DNA repair gene transfer into xeroderma pigmentosum cells: Perspectives for a gene therapy (1998) (13)
The paradox of DNA repair-deficient diseases (1991) (13)
Efficient repair of cyclobutane pyrimidine dimers at mutational hot spots is restored in complemented Xeroderma pigmentosum group C and trichothiodystrophy/xeroderma pigmentosum group D cells. (2003) (13)
Genetic reversion of inherited skin disorders. (2002) (13)
Regulation of the Escherichia coli lac operon expressed in human cells. (1992) (12)
Genetic variants in DNA repair pathways and risk of upper aerodigestive tract cancers: combined analysis of data from two genome-wide association studies in European populations. (2014) (11)
XPD/ERCC2 mutations interfere in cellular responses to oxidative stress. (2019) (11)
Comparative study of nucleotide excision repair defects between XPD-mutated fibroblasts derived from trichothiodystrophy and xeroderma pigmentosum patients. (2008) (11)
NK cell and fibroblast-mediated regulation of skin squamous cell carcinoma invasion by CLEC2A is compromised in Xeroderma Pigmentosum. (2020) (11)
Psychological correlates of adherence to photoprotection in a rare disease: International survey of people with Xeroderma Pigmentosum (2019) (11)
Stimulated production of ATP by H2O2 disproportionation in extracts from normal and xeroderma pigmentosum skins, and from normal, xeroderma pigmentosum, ataxia telangiectasia and simian virus 40 transformed cell lines. (1989) (10)
Xeroderma pigmentosum in South Africa: Evidence for a prevalent founder effect (2019) (10)
Xeroderma pigmentosum. Etude de 40 malades algériens. (1996) (10)
Helical polysomes induced by aflatoxin B1 in vivo. A new hypothesis for helix formation by chemicals and carcinogens. (1976) (10)
Shuttle vectors for studying mutagenesis in mammalian cells. (1989) (10)
Enhanced Deoxyribonuclease Activity in Human Transformed Cells and in Bloom's Syndrome Cells (1989) (10)
Defective transcription of ATF3 responsive genes, a marker for Cockayne Syndrome (2020) (10)
DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination. (2018) (10)
Adenovirus mediated transduction of the human DNA polymerase eta cDNA. (2006) (9)
Simian virus 40 as a probe for studying inducible repair functions in mammalian cells. (1981) (9)
Prevalence of human papillomavirus in skin tumors from repair deficient xeroderma pigmentosum patients. (2007) (9)
Mutation spectrum of 4-nitroquinoline 1-oxide-damaged single-stranded shuttle vector DNA transfected into monkey cells. (1994) (9)
Xeroderma pigmentosum group C in a French Caucasian patient with multiple melanoma and unusual long‐term survival (2008) (9)
[A whole family affected by xeroderma pigmentosum: clinical and genetic particularities]. (2003) (9)
Flow cytometric detection of drugs altering the DNA methylation pattern. (1992) (9)
Novel complementation assays for DNA repair-deficient cells. Transient and stable expression of DNA repair genes. (1999) (9)
How history and geography may explain the distribution in the Comorian archipelago of a novel mutation in DNA repair-deficient xeroderma pigmentosum patients (2019) (8)
Increased risk of internal tumors in DNA repair-deficient xeroderma pigmentosum patients: analysis of four international cohorts (2021) (8)
Implication of uracil in spontaneous mutagenesis on a single-stranded shuttle vector replicated in mammalian cells. (1993) (8)
Induced mutagenesis of Simian virus 40 in carcinogen-treated monkey cells. (1983) (8)
INK4a‐ARF mutations in skin carcinomas from UV irradiated hairless mice (2004) (8)
[Mutations and cancer]. (1989) (8)
Spontaneous and ultraviolet-induced mutations on a single-stranded shuttle vector transfected into monkey cells. (1992) (8)
Diagnosis of Xeroderma pigmentosum variant in a young patient with two novel mutations in the POLH gene (2017) (8)
Effect of tumor promoters on soft-agar growth of Swiss 3T3 cells infected with SV40 tsA mutants. (1982) (8)
BRN2 is a non-canonical melanoma tumor-suppressor (2019) (7)
Mutagenesis by O6 meG residues within codon 12 of the human Ha-ras proto-oncogene in monkey cells. (1992) (7)
Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η (2020) (7)
Gene Expression Pro fi ling of Primary Cutaneous Melanoma and Clinical Outcome (2006) (7)
How chemicals may induce cancer. (1976) (7)
Resistance to ultraviolet-induced apoptosis in DNA repair deficient growth arrested human fibroblasts is not related to recovery from RNA transcription blockage. (2008) (7)
XPC (xeroderma pigmentosum, complementation group C) (2011) (6)
Reconstruction of DNA Repair–deficient Xeroderma Pigmentosum Skin In Vitro: A Model to Study Hypersensitivity to UV Light¶ (2005) (6)
Constraints in simian virus 40 (SV40) encapsidation, as determined by SV40-based shuttle viruses. (1990) (6)
SIMIAN VIRUS 40 AS A PROBE FOR STUDYING DNA REPAIR PATHWAYS IN MAMMALIAN CELLS (1978) (6)
Mammalian cell processing of a unique uracil residue in simian virus 40 DNA. (1990) (6)
Complementation assays adapted for DNA repair-deficient keratinocytes. (2006) (6)
Inhibition of gene expression by anti-sense C-5 propyne oligonucleotides detected by a reporter enzyme. (1999) (6)
Regulated expression of Epstein-Barr virus nuclear antigen 3-encoding gene carried on stable episomal vectors in human cells. (1990) (5)
Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells. (2016) (5)
Formation of active 40 S ribosomal subunits in liver in the presence of aflatoxin B1. (1974) (5)
Aberrant C-terminal domain of polymerase η targets the functional enzyme to the proteosomal degradation pathway. (2015) (5)
Adenovirus-mediated anti insulin-like growth factor I gene transfer for the treatment of hepatocellular carcinoma. (2002) (5)
DNA repair pathways and associated human diseases. (2003) (4)
Cellular genes possibly involved in the transformation process of the human melanoma cell line XP44 RO (Mel). (1995) (4)
[Trichothiodystrophies: anomalies of the repair and transcription of genes]. (1999) (4)
XPA (xeroderma pigmentosum, complementation group A) (2011) (4)
Conversion of a single-stranded simian virus 40 (SV40)-based shuttle vector to its double-stranded form does not require the SV40 T antigen in monkey cells. (1991) (4)
Neurological manifestations in two related xeroderma pigmentosum group d patients: Complications of the late‐onset type of the juvenile form (1997) (4)
The Effect of 12-0-Tetradecanoyl-Phorbol-13-Acetate (TPA) on Cell Transformation by Simian Virus 40 Mutants (1980) (4)
Transcription-coupled repair of 8-oxoguanine in human cells. (2002) (4)
[Trichothiodystrophy: progresssive manifestations]. (1999) (4)
Molecular mechanisms of mutagenesis in mammalian cells: present and future. (1989) (3)
The xeroderma pigmentosum variant in a Greek patient (2001) (3)
ERCC-3 (excision repair cross-complementing rodent repair deficiency, complementation group 3) (2011) (3)
Susceptibility of Xeroderma pigmentosum cells to transformation with oncogenes. (1988) (3)
Comparison of spontaneous and ultraviolet-induced mutagenesis on naked SV40 DNA and SV40 virus. (1991) (3)
Progress and prospects of xeroderma pigmentosum therapy. (2008) (3)
[Xeroderma pigmentosum. A study in 40 Algerian patients]. (1996) (3)
Photogenotoxicity of Mammalian Cells: A Review of the Different Assays for In Vitro Testing ¶ (2002) (3)
P XVII A.8 8-Oxoguanine: Mutagenesis and repair (1997) (3)
The Iberian legacy into a young genetic xeroderma pigmentosum cluster in central Brazil. (2020) (2)
1 ROLE OF DNA POLYMERASES η , ι AND ζ IN UV RESISTANCE AND UV-INDUCED MUTAGENESIS IN A HUMAN CELL LINE . (2017) (2)
Amplification of Epstein-Barr virus-based shuttle vectors by ultraviolet light in human cells. (1991) (2)
UVSSA and USP7: new players regulating transcription-coupled nucleotide excision repair in human cells (2012) (2)
Deficiency in the catalase activity in human precancerous stages of Xeroderma pigmentosum: Comparison with XP, at and blomm's cultured fibroblasts and SV40 transformed human cell extracts☆ (1987) (2)
The use of animal virus or shuttle vectors to characterize mutagenesis in mammalian cells. (1986) (2)
Molecular analysis of mutagenesis in mammalian cells. (1985) (2)
XPC and POLH/XPV Genes Mutated in a Genetic Cluster of Xeroderma Pigmentosum Patients in Northeast Brazil (2022) (2)
Specific UV-induced mutation spectrum in the p 53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients ( skin cancer / p 53 tumor suppressor gene ) (2005) (2)
[Xeroderma pigmentosum. What may be expected from biological studies?]. (1994) (2)
DNA Ligase Activity in Human Cells from Normal Donors and from Patients with Bloom’s Syndrome and Fanconi’s Anemia (1989) (2)
Efficient in vivo encapsidation of a shuttle vector into pseudo-simian virus 40 virions using a shuttle virus as helper. (1992) (2)
Gene expression profiling of primary cutaneous melanoma: Expression of replication origins firing genes predicts clinical outcome. (2006) (1)
[Xeroderma pigmentosum]. (1997) (1)
ERCC 2 ( Excision repair cross-complementing rodent repair deficiency , complementation group 2 ) (2011) (1)
Survival and mutagenesis of ultraviolet irradiated simian virus 40 in foetal human fibroblasts. (1985) (1)
Analysis of Skin Cancers from Xeroderma Pigmentosum Patients Reveals Heterogeneous UV-Induced Mutational Profiles Shaped by DNA Repair (2022) (1)
Mechanisms and consequences of mutation induction in mammalian cells. (1990) (1)
Atlas of Genetics and Cytogenetics in Oncology and Haematology Nucleotide excision repair (2006) (1)
Advances in Brief Significantly High Levels of Ultraviolet-specific Mutations in the Smoothened Gene in Basal Cell Carcinomas from DNA Repair-deficient Xeroderma Pigmentosum Patients 1 (2002) (1)
Single stranded DNA-vectors for analyzing processing of DNA damage induced by 4-nitroquinoline-1-oxide in prokaryotes and eukaryotes. (1992) (1)
Preclinical Development Trabectedin and Its C Subunit Modified Analogue PM 01183 Attenuate Nucleotide Excision Repair and Show Activity toward Platinum-Resistant Cells (2011) (1)
XPE (xeroderma pigmentosum, complementation group E) (2011) (1)
Choice between death by senescence or by cancer? (2003) (1)
Ultraviolet-light induces a copy number increase of Epstein-Barr virus-based shuttle vectors. (1991) (1)
Xeroderma Pigmentosum: When the Sun Is the Enemy (2014) (1)
Carcinogen-induced mutagenesis in the simian virus 40 genome. (1989) (1)
Use of an infectious Simian virus 40-based shuttle vector to analyse UV-induced mutagenesis in monkey cells. (1996) (1)
Recent Research Developments in DNA Repair and Mutagenesis (2003) (1)
Melanoma associated with Xeroderma pigmentosum: a pathological analysis of 23 cases (1997) (1)
Study of BRAF mutations in melanoma and nevi from patients with germline mutation in the CDKN2A gene. (2006) (1)
DNA Polymerases and DNA Repair in Eukaryotic Cells (1983) (1)
ヒトXPD遺伝子を導入後のトリコチオジストロフィー(裂毛症)細胞における,正常なDNA修復活性と変異の発現 (1996) (0)
Melanoma gene expression profiling: prognostic markers and insight in tumor progression (2008) (0)
Oncogene Activation in Xeroderma Pigmentosum Skin Tumors (1989) (0)
P VII. 6 Oxidative stress regulation after retroviral-mediated correction of xeroderma pigmentosum group D and C fibroblasts (1997) (0)
Abstract A125: Profound impact of the nucleotide excision repair proteins XPC and CSB, but not ERCC1, on the resistance to an antitumor alkylator destabilizing local DNA duplex structure (2009) (0)
P VII.20 UV-irradiation induces the expression of a mouse gene encoding a nuclear DNA-binding protein akin to E. coli RecA protein (1997) (0)
DNA repair and cell survival of normal and xeroderma pigmentosum keratinocytes after UV irradiation (1998) (0)
Characterization of a mutant rat kangaroo cell line with alterations in the cell cycle and DNA repair (2000) (0)
Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η (2020) (0)
High mutation frequency of the patched gene in basal cell carcinomas from xeroderma pigmentosum patients (1998) (0)
Defects in Transcription-Coupled Repair of Oxidative Base Damage in Xeroderma Pigmentosum with Cockayne Syndrome (1997) (0)
Deficiency in the Catatase Activity of Xeroderma Pigmentosum Cell and Simian Virus 40-transformed Human Cell Extracts1 (2006) (0)
Alternative response pathways to ultraviolet irradiation in the lack of nucleotide excision repair (2011) (0)
Characterization of primary fibroblast from xeroderma pigmentosum patients from Araras (GO) Brazil (2011) (0)
SOS Functions Induced in Carcinogen-Treated Mammalian Cells (1983) (0)
Mutagenesis after transfection of monkey kidney cells with acetoxyacetylaminofluorene-treated (AAAF) or depurinated simian virus 40 (SV40) DNA (1984) (0)
P V.24 Retroviral-mediated correction of skin cancer-prone, DNA repair-deficient phenotype of xeroderma pigmentosum: Towards a gene therapy (1997) (0)
Heterogeneity ofmammalian DNA lgase detected onactiviy andDNA sequencing gels (1984) (0)
Defective transcription of ATF3 responsive genes, a marker for Cockayne Syndrome (2020) (0)
[Effect of aflatoxin on protein biosynthesis in the rat liver]. (1972) (0)
Implications of the proteins p53, c-myc and bcl-2 in apoptosis of hepatocarcinoma cell lines transfected with antisense IGF-I cDNA (1998) (0)
Keys of oxidative stress in DNA repair-corrected-defects in XP cells. Analyses cell per cell by ultramicroelectrochemistry (1999) (0)
Induced DNA repair and DNA replication of Simian virus 40 in carcinogen-treated monkey cells (1982) (0)
Effects of Various Promoters on Cell Transformation by Simian Virus 40 Mutants (1983) (0)
ONCOGENE ACTIVATION IN ULTRAVIOLET-INDUCED SKIN TUMORS FROM NORMAL INDIVIDUALS AND XERODERMA PIGMENTOSUM PATIENTS (1992) (0)
Analysis of spontaneous and UV-induced mutagenesis on SV40:pyrimidine dimers versus pyrimidine (6-4) pyrimidones and viral infection versus DNA transfection. (1990) (0)
NAMPT inhibition is a novel synthetic lethal therapeutic approach exploiting nuclear-mitochondrial crosstalk in ERCC1-deficient populations. (2017) (0)
P XIV B.21 Impaired DNA repair as assessed by the «Comet» assay in patients with thyroid carcinoma after radiotherapy (1997) (0)
Single-Strand DNA Shuttle Vectors for Analyzing DNA-Damage Processing (1991) (0)
Singlet oxygen induced mutagenicity in epissomal sv-40 derived shuttle vector (1989) (0)
Iconography : Trichothiodystrophies : manifestations évolutives (2008) (0)
O V B.2 A molecular signal for the UV-induced p53 protein stabilization (1997) (0)
Mutational signatures and increased retrotransposon insertions in Xeroderma Pigmentosum variant skin tumors (2022) (0)
Mammalian DNA Ligase : Studies on the Structure and Function during DNA Replication and Repair (1989) (0)
522 The marine-derived product PM01183 shows activity toward platinum-resistant cells and attenuates nucleotide excision repair (2010) (0)
[Xeroderma pigmentosum associated with Cockayne's syndrome]. (1992) (0)
P V.19 UV-C induced mutagenesis in repair deficient human cells (1997) (0)
Epigenomic signature of the progeroid Cockayne syndrome exposes distinct and common features with physiological ageing (2021) (0)
Contraints in sv40 encapsidation as determined by sv40 - base shuttle viruses (1988) (0)
Molecular mechanisms of mutagenesis in mammalian cells use of sv 40 and shuttle virus as probes (1988) (0)
Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repairytranscription gene (nucleotide excision repairytranscription factor TFIIHyUV irradiation) (1997) (0)
IN VZVO EFFECT OF AFLATOXIN B, ON PROTEIN SYNTHESIS IN RAT LIVER (1973) (0)
POLH (polymerase (DNA direct), eta) (2011) (0)
Molecular analysis of UV-induced mutagenesis of SV40 in mammalian cells (1984) (0)
Defects intheDNA Repair andTranscription GeneERCC2(XPD) in Trichothiodystro phy (1996) (0)
Gene expression profiling of primary cutaneous melanoma and clinical outcome: role of DNA repair genes in metastasis development (2006) (0)
P V.22 The induction of apoptosis in fibroblasts from UV sensitive repair deficient hereditary syndromes (1997) (0)
2nd German-French DNA repair meeting – DNA damage and repair in ageing and degenerative diseases, Konstanz, Germany, September 20–23, 2009 (2010) (0)
290 POSTER The cytotoxic activity of the monofunctionaol alkylator S23906 is mediated by generation of DNA double strand breaks that are repaired by homologous recombination in mammalian cells (2006) (0)
HighRecombination Rateofan Epstein-Barr Virus-Simian Virus40 HybridShuttle Vector inHumanCells (1989) (0)
[DNA repair and related diseases]. (1992) (0)
Modifications in DNA Ligase Activity During DNA Repair in Mammalian Cells (2020) (0)
Expression of Constitutive Fusion of Ubiquitin to PCNA Restores the Level of Immunoglobulin A/T Mutations During Somatic Hypermutation in the Ramos Cell Line (2022) (0)
Activation of oncogenesis in skin tumors from a repair-deficient syndrome, xeroderma pigmentosum (1990) (0)
Nucleotide Excision Repair (2011) (0)
ERCC4 (xeroderma pigmentosum, complementation group F) (2011) (0)
ERCC5 (xeroderma pigmentosum, complementation group G) (2011) (0)
[40 S ribonucleoproteins from rat liver nuclei. II. Properties of the RNA of these particles]. (1969) (0)
Flow Cytometric Detection of Drugs Altering the DNA Methylation Pattern1 (2006) (0)
NAMPT inhibition is a novel synthetic lethal therapeutic approach exploiting nuclear–mitochondrial crosstalk in ERCC1-deficient populations (2016) (0)
Flow Cytometric Detection of Drugs Altering the DNA Methylation Pattern 1 (2006) (0)
TRICHOTHIODYSTROPHY SYNDROMES : DEFINITION , CLASSIFICATION , AND CLINICAL FEATURES Definition and diagnosis (2001) (0)
[Deficiency in reparases]. (1989) (0)
Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients (2023) (0)
Mutagenesis in the cells of mammals (1984) (0)
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2001) (0)
Activated oxygen species and human carcinogenesis in relation to the cellular defense potentiality (1990) (0)
DNAsynthesis blocking lesions induced bysinglet oxygen aretargeted todeoxyguanosines (1992) (0)
[Rothmund-Thomson syndrome and defective DNA excision-resynthesis repair]. (2000) (0)
S09 03 MA – ONCOGENE ACTIVATION IN ULTRAVIOLET-INDUCED SKIN TUMORS FROM NORMAL INDIVIDUALS AND XERODERMA PIGMENTOSUM PATIENTS (1991) (0)
[DNA lesions: mechanisms of recognition and repair]. (1997) (0)
Activity gels tor analysing DNA processing enzyrn (1986) (0)
Induced reactivity of UV-damaged phage gamma in E. coli K12 host cells treated with aflatoxin B1 metabolites. (1977) (0)

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