Alan Brash

Q: What Schools Are Affiliated With Alan Brash

Alan Brash is affiliated with the following schools: Vanderbilt University, Royal Postgraduate Medical School, University of Edinburgh, Stanford University, University of California, San Francisco, University of Cambridge

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Alan Brash

Medical

#1585

World Rank

#1940

Historical Rank

#400

USA Rank

Pharmacology

#174

World Rank

#213

Historical Rank

#32

USA Rank

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Alan Brash 's Degrees

PhD Pharmacology University of California, San Francisco
Bachelors Biology Stanford University

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Why Is Alan Brash Influential?

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According to Wikipedia, Alan Richard Brash is a professor of pharmacology at Vanderbilt University. He is a leading authority on the biosynthesis of prostoglandins and eicosanoids. Biography Education Brash was educated at Strathallan School near Perth, Scotland and Downing College, Cambridge, where he was elected a scholar. He graduated with a BA in medical sciences in 1970 and proceeded to the University of Edinburgh to study for his PhD, graduating in 1976. Brash was then appointed a research fellow in the Department of Clinical Pharmacology at the Royal Postgraduate Medical School in London. Thereafter, he moved to Vanderbilt University.

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Alan Brash 's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate* (1999) (1237)
Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. (1983) (671)
Arachidonic acid as a bioactive molecule. (2001) (518)
Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. (1984) (512)
Release of prostaglandin D2 into human airways during acute antigen challenge. (1986) (489)
Discovery of a second 15S-lipoxygenase in humans. (1997) (381)
The Structure of Human 5-Lipoxygenase (2011) (342)
Two Distinct Pathways of Formation of 4-Hydroxynonenal (2001) (294)
Control of oxygenation in lipoxygenase and cyclooxygenase catalysis. (2007) (286)
Estimated rate of prostacyclin secretion into the circulation of normal man. (1981) (285)
Molecular cloning of an allene oxide synthase: a cytochrome P450 specialized for the metabolism of fatty acid hydroperoxides. (1993) (279)
Purification of an allene oxide synthase and identification of the enzyme as a cytochrome P-450. (1991) (249)
Routes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation* (2008) (236)
Prostacyclin production during pregnancy: comparison of production during normal pregnancy and pregnancy complicated by hypertension. (1982) (233)
Oxygenation of biological membranes by the pure reticulocyte lipoxygenase. (1990) (225)
15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells. (2001) (225)
Arachidonic acid 15-lipoxygenase products from human eosinophils. (1982) (179)
A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression. (1998) (179)
15-Lipoxygenase Metabolism of 2-Arachidonylglycerol (2002) (171)
A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation. (2004) (168)
Expression of a Flax Allene Oxide Synthase cDNA Leads to Increased Endogenous Jasmonic Acid (JA) Levels in Transgenic Potato Plants but Not to a Corresponding Activation of JA-Responding Genes. (1995) (157)
The structural basis for specificity in lipoxygenase catalysis (2015) (156)
Preparation and assay of monohydroxy-eicosatetraenoic acids. (1980) (154)
Modulation of human neutrophil function by monohydroxy-eicosatetraenoic acids. (1980) (151)
15-lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma. (1999) (150)
Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man. (1983) (150)
Analysis of a specific oxygenation reaction of soybean lipoxygenase-1 with fatty acids esterified in phospholipids. (1987) (148)
Arachidonic acid metabolism in rabbit renal cortex. Formation of two novel dihydroxyeicosatrienoic acids. (1981) (146)
The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase (2003) (144)
Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids. (1986) (135)
Lipoxygenases Mediate the Effect of Essential Fatty Acid in Skin Barrier Formation (2011) (128)
Pharmacokinetics of indomethacin in the neonate. Relation of plasma indomethacin levels to response of the ductus arteriosus. (1981) (128)
Quantitative analysis of two dinor urinary metabolites of prostaglandin I2. (1981) (117)
Alterations in lipoxygenase and cyclooxygenase-2 catalytic activity and mRNA expression in prostate carcinoma. (2001) (116)
Molecular Cloning and Functional Expression of a Phorbol Ester-inducible 8S-Lipoxygenase from Mouse Skin* (1997) (114)
Eggs of the sea urchin, Strongylocentrotus purpuratus, contain a prominent (11R) and (12R) lipoxygenase activity. (1987) (111)
Conversion of human 5‐lipoxygenase to a 15‐lipoxygenase by a point mutation to mimic phosphorylation at Serine‐663 (2012) (109)
Measurement of urinary 2,3-dinor-thromboxane B2 and thromboxane B2 using bonded-phase phenylboronic acid columns and capillary gas chromatography--negative-ion chemical ionization mass spectrometry. (1985) (107)
Identification of a naturally occurring peroxidase-lipoxygenase fusion protein. (1997) (105)
Isolation and characterization of natural allene oxides: unstable intermediates in the metabolism of lipid hydroperoxides. (1988) (104)
Insights from the X-ray Crystal Structure of Coral 8R-Lipoxygenase (2005) (103)
Metabolic disposition of prostacyclin in humans. (1983) (103)
Studies of prostaglandins and sulphasalazine in ulcerative colitis. (1981) (102)
The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier. (2014) (98)
Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition. (2011) (97)
PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis (2017) (96)
Functional Expression and Cellular Localization of a Mouse Epidermal Lipoxygenase* (1996) (96)
A comprehensive model of positional and stereo control in lipoxygenases. (2005) (94)
Identification of Amino Acid Determinants of the Positional Specificity of Mouse 8S-Lipoxygenase and Human 15S-Lipoxygenase-2* (2000) (93)
On singular or dual positional specificity of lipoxygenases. The number of chiral products varies with alignment of methylene groups at the active site of the enzyme. (1990) (92)
Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells. (1990) (91)
Enhancement of chemotactic factor-stimulated neutrophil oxidative metabolism by leukotriene B4. (1984) (89)
The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity. (2009) (89)
Rabbit reticulocyte lipoxygenase catalyzes specific 12(S) and 15(S) oxygenation of arachidonoyl-phosphatidylcholine. (1988) (86)
Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids. (2001) (86)
Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12-lipoxygenases. (1993) (86)
8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytes. (2000) (84)
Purification and Molecular Cloning of an 8R-Lipoxygenase from the Coral Plexaura homomalla Reveal the Related Primary Structures of R- and S-Lipoxygenases* (1996) (84)
Mechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymes. (2009) (84)
On non-cyclooxygenase prostaglandin synthesis in the sea whip coral, Plexaura homomalla: an 8(R)-lipoxygenase pathway leads to formation of an alpha-ketol and a Racemic prostanoid. (1987) (81)
Formation of a novel dihydroxy acid from arachidonic acid by lipoxygenase-catalyzed double oxygenation in rat mononuclear cells and human leukocytes. (1982) (81)
The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide. (2005) (80)
Activation of soluble guanylate cyclase by arachidonic acid and 15-lipoxygenase products. (1986) (79)
Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma. (2003) (78)
Formation of epoxyalcohols by a purified allene oxide synthase. Implications for the mechanism of allene oxide synthesis. (1993) (77)
Stereospecific induction of starfish oocyte maturation by (8R)-hydroxyeicosatetraenoic acid. (1986) (76)
A second pathway of leukotriene biosynthesis in porcine leukocytes. (1981) (76)
Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytes. (1983) (75)
Absolute configuration of cis-12-oxophytodienoic acid of flaxseed: implications for the mechanism of biosynthesis from the 13(S)-hydroperoxide of linolenic acid. (1988) (71)
Control of Prostaglandin Stereochemistry at the 15-Carbon by Cyclooxygenases-1 and -2 (2002) (71)
The discovery and early structural studies of arachidonic acid (2016) (70)
The hepoxilin connection in the epidermis (2007) (70)
Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation. (2004) (68)
Purification and Catalytic Activities of the Two Domains of the Allene Oxide Synthase-Lipoxygenase Fusion Protein of the CoralPlexaura homomalla * (1999) (68)
Stereospecificity of Hydrogen Abstraction in the Conversion of Arachidonic Acid to 15R-HETE by Aspirin-treated Cyclooxygenase-2 (2000) (67)
On the Evolutionary Origin of Cyclooxygenase (COX) Isozymes (2004) (67)
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors. (2002) (65)
The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: Molecular cloning and expression of a novel cyclooxygenase (2001) (64)
A review of possible roles of the platelet 12-lipoxygenase. (1985) (64)
INCREASED PROSTAGLANDIN PRODUCTION IN ULCERATIVE COLITIS (1977) (64)
Allene oxide synthases and allene oxides. (2002) (64)
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3. (2005) (63)
Formation of lipoxin B by the pure reticulocyte lipoxygenase via sequential oxygenation of the substrate. (1987) (63)
Purification, molecular cloning, and expression of the gene encoding fatty acid 13-hydroperoxide lyase from guava fruit (Psidium guajava) (2000) (62)
Autoxidation of methyl linoleate: Identification of the bis-allylic 11-hydroperoxide (2000) (62)
On the Relationships of Substrate Orientation, Hydrogen Abstraction, and Product Stereochemistry in Single and Double Dioxygenations by Soybean Lipoxygenase-1 and Its Ala542Gly Mutant* (2005) (62)
Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system. (1993) (61)
Reduced 15-lipoxygenase-2 immunostaining in prostate adenocarcinoma: correlation with grade and expression in high-grade prostatic intraepithelial neoplasia. (2000) (61)
The Basis of Prostaglandin Synthesis in Coral (2001) (61)
A mouse mutation in the 12R-lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier. (2007) (55)
A 49-kDa Mini-lipoxygenase from Anabaena sp. PCC 7120 Retains Catalytically Complete Functionality* (2008) (55)
Enantiomeric separation of hydroxy eicosanoids by chiral column chromatography: effect of the alcohol modifier. (2000) (55)
Crystal Structure of a Lipoxygenase in Complex with Substrate (2014) (55)
Cytochrome P450-dependent transformations of 15R- and 15S-hydroperoxyeicosatetraenoic acids: stereoselective formation of epoxy alcohol products. (1996) (54)
Stereospecific removal of the DR hydrogen atom at the 10-carbon of arachidonic acid in the biosynthesis of leukotriene A4 by human leukocytes. (1982) (53)
Epidermal Lipoxygenase Products of the Hepoxilin Pathway Selectively Activate the Nuclear Receptor PPARα (2007) (53)
Metabolism of linoleic and arachidonic acids in VX2 carcinoma tissue: identification of monohydroxy octadecadienoic acids and monohydroxy eicosatetraenoic acids. (1980) (53)
Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin. (1991) (53)
Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein–lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120 (2007) (52)
Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal. (2004) (51)
A short-chain aldehyde is a major lipoxygenase product in arachidonic acid-stimulated porcine leukocytes. (1986) (51)
Discovery of a second 15 S-lipoxygenase in humans (1997) (49)
Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products. (2008) (49)
15-Lipoxygenase-2 expression in benign and neoplastic sebaceous glands and other cutaneous adnexa. (2001) (49)
Interleukin-4 Induces 15-Lipoxygenase-1 Expression in Human Orbital Fibroblasts from Patients with Graves Disease (2006) (48)
7-HETE, 10-HETE, and 13-HETE are major products of NADPH-dependent arachidonic acid metabolism in rat liver microsomes: analysis of their stereochemistry, and the stereochemistry of their acid-catalyzed rearrangement. (1995) (48)
Identification of Two Cyclooxygenase Active Site Residues, Leucine 384 and Glycine 526, That Control Carbon Ring Cyclization in Prostaglandin Biosynthesis* (2004) (46)
Formation of an allene oxide from (8R)-8-hydroperoxyeicosatetraenoic acid in the coral Plexaura homomalla (1989) (46)
Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenal (2005) (44)
Lipoxin synthesis by arachidonate 12-lipoxygenase purified from porcine leukocytes. (1987) (44)
Acute renal artery constriction increases renal prostaglandin I2 biosynthesis and renin release in the conscious dog. (1982) (44)
Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography. (2007) (43)
Evidence of a Cyclooxygenase-related Prostaglandin Synthesis in Coral (1999) (43)
Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. (1985) (43)
Endometrial prostaglandins and phospholipase activity related to implantation in rabbits: effects of dexamethasone. (1984) (42)
SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation. (2020) (41)
Detection and subcellular localization of two 15S-lipoxygenases in human cornea. (2005) (41)
Identification and characterization of an arachidonate 11R-lipoxygenase. (2006) (40)
Quantitative determination of the major metabolite of prostaglandins F1alpha and F2alpha in human urine by stable isotope dilution and combined gas chromatography--mass spectrometry. (1976) (40)
Identification of lipoxygenase products from arachidonic acid metabolism in stimulated murine eosinophils. (1983) (40)
High-performance liquid chromatography for chiral analysis of eicosanoids. (1990) (40)
Allene oxide and aldehyde biosynthesis in starfish oocytes. (1991) (39)
On the Role of Molecular Oxygen in Lipoxygenase Activation (2010) (39)
Detection, assay, and isolation of allene oxide synthase. (1996) (38)
Characterization of the coral allene oxide synthase active site with UV-visible absorption, magnetic circular dichroism, and electron paramagnetic resonance spectroscopy: evidence for tyrosinate ligation to the ferric enzyme heme iron. (2001) (38)
Evidence for an Ionic Intermediate in the Transformation of Fatty Acid Hydroperoxide by a Catalase-related Allene Oxide Synthase from the Cyanobacterium Acaryochloris marina* (2009) (38)
Dioxygenase Activity of Epidermal Lipoxygenase-3 Unveiled (2010) (37)
Discovery of 5R-lipoxygenase activity in oocytes of the surf clam, Spisula solidissima. (1997) (36)
Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity. (2006) (36)
Omega-3 fatty acids are oxygenated at the n-7 carbon by the lipoxygenase domain of a fusion protein in the cyanobacterium Acaryochloris marina. (2010) (35)
Formation of a cyclopropyl eicosanoid via an allene oxide in the coral Plexaura homomalla: implications for the biosynthesis of 5,6-trans-prostaglandin A2 (1989) (35)
Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin. (2006) (34)
Detection and cellular localization of 12R-lipoxygenase in human tonsils. (2001) (33)
Resolution of enantiomers of hydroxyeicosatetraenoate derivatives by chiral phase high-pressure liquid chromatography. (1988) (33)
Investigation of Substrate Binding and Product Stereochemistry Issues in Two Linoleate 9-Lipoxygenases (2008) (31)
Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope. (2019) (31)
Straight phase separation of prostaglandin methyl esters on lipophilic gels. (1974) (30)
MECHANISM OF THE REARRANGEMENT OF VINYL ALLENE OXIDE TO 2-CYCLOPENTEN-1-ONE (1999) (29)
Investigation of the selectivity of hydrogen abstraction in the nonenzymatic formation of hydroxyeicosatetraenoic acids and leukotrienes by autoxidation. (1985) (28)
Lipoxygenase-catalyzed formation of R-configuration hydroperoxides. (2002) (28)
Mechanistic Aspects of CYP74 Allene Oxide Synthases and Related Cytochrome P450 Enzymes (2010) (28)
Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities. (2005) (28)
Structural and functional comparison of 15S- and 15R-specific cyclooxygenases from the coral Plexaura homomalla. (2004) (28)
Structure-function features of flaxseed allene oxide synthase. (1995) (27)
Molecular cloning of a second human 15S-lipoxygenase and its murine homologue, an 8S-lipoxygenase. Their relationship to other mammalian lipoxygenases. (1999) (25)
An Ancient Relative of Cyclooxygenase in Cyanobacteria Is a Linoleate 10S-Dioxygenase That Works in Tandem with a Catalase-related Protein with Specific 10S-Hydroperoxide Lyase Activity* (2014) (24)
The Precise Structures and Stereochemistry of Trihydroxy-linoleates Esterified in Human and Porcine Epidermis and Their Significance in Skin Barrier Function (2016) (24)
Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues. (1999) (23)
Investigation of the allene oxide pathway in the coral Plexaura homomalla: formation of novel ketols and isomers of prostaglandin A2 from 15-hydroxyeicosatetraenoic acid. (1991) (23)
Formation of prostaglandin A analogues via an allene oxide. (1990) (23)
Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function (2018) (22)
Steric analysis of epoxyalcohol and trihydroxy derivatives of 9-hydroperoxy-linoleic acid from hematin and enzymatic synthesis. (2013) (22)
A comparison of t-butyldimethylsilyl and trimethylsilyl ether derivatives for the characterization of urinary metabolites of prostaglandin F2alpha by gas chromatography mass spectrometry. (1978) (22)
ENDOGENOUS PROSTACYCLIN AND THROMBOXANE BIOSYNTHESIS DURING CHRONIC VITAMIN E THERAPY IN MAN (1982) (21)
On the Relationship of Coral Allene Oxide Synthase to Catalase (2006) (19)
Stereoselective hydrogen abstraction in leukotriene A4 synthesis by purified 5-lipoxygenase of porcine leukocytes. (1986) (19)
Role of the conserved distal heme asparagine of coral allene oxide synthase (Asn137) and human catalase (Asn148): mutations affect the rate but not the essential chemistry of the enzymatic transformations. (2008) (19)
Isolation and Characterization of Two Geometric Allene Oxide Isomers Synthesized from 9S-Hydroperoxylinoleic Acid by Cytochrome P450 CYP74C3 (2013) (19)
Influence of selenium status on activity of phospholipid hydroperoxide glutathione peroxidase in rat liver and testis in comparison with other selenoproteins (1996) (19)
Mechanism of biosynthesis of 11R‐ and 12R‐hydroxyeicosatetraenoic acids by eggs of the sea urchin Strongylocentrotus purpuratus (1989) (18)
Lipoxygenase metabolism of endogenous and exogenous arachidonate in leukocytes: GC-MS analyses of incubations in H2(18)O buffers. (1986) (18)
Prostaglandin D2 is released during acute allergic bronchospasm in man. (1985) (18)
Biochemical Studies on Mammalian Lipoxygenases a , b (1988) (18)
Demonstration of Ubiquitin Thiolester Formation of UBE2Q2 (UBCi), a Novel Ubiquitin-Conjugating Enzyme with Implantation Site-Specific Expression1 (2006) (17)
Upregulation of 8-Lipoxygenase in the Dermatitis of IκB-α-Deficient Mice (2004) (17)
A Catalase-related Hemoprotein in Coral Is Specialized for Synthesis of Short-chain Aldehydes (2015) (16)
High levels of circulating prostaglandin F2α associated with ovulation stimulate female sexual receptivity and spawning behavior in the goldfish (Carassius auratus). (2018) (15)
Differential Expression of Genes in the Endometrium at Implantation: Upregulation of a Novel Member of the E2 Class of Ubiquitin-Conjugating Enzymes1 (2004) (15)
Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions (2021) (14)
Identification of 12(S)-hydroxyeicosatetraenoic acid in the young rat lens. (1991) (14)
Coordination modes of tyrosinate-ligated catalase-type heme enzymes: magnetic circular dichroism studies of Plexaura homomalla allene oxide synthase, Mycobacterium avium ssp. paratuberculosis protein-2744c, and bovine liver catalase in their ferric and ferrous states. (2011) (13)
Investigation of the chemical conversion of hydroperoxyeicosatetraenoate to leukotriene epoxide using stereospecifically labeled arachidonic acid. Comparison with the enzymatic reaction. (1985) (13)
Characterization of HETEs and related conjugated dienes by UV spectroscopy (1988) (13)
Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice. (2004) (13)
SYSTEMIC PROSTAGLANDIN I2 SYNTHESIS IS NORMAL IN PATIENTS WITH BARTTER'S SYNDROME (1983) (12)
Applications of Stereospecifically-Labeled Fatty Acids in Oxygenase and Desaturase Biochemistry (2012) (12)
Metabolic fate of thromboxane A2 and prostacyclin. (1982) (12)
A covalent linker allows for membrane targeting of an oxylipin biosynthetic complex. (2008) (12)
Aspirin inhibits endogenous prostacyclin and thromboxane biosynthesis in man. (1983) (11)
Endogenous prostacyclin synthesis is decreased during activation of the renin-angiotensin system in man. (1984) (11)
Synthesis and Applications of Stereospecifically 3H-Labeled Arachidonic Acids as Mechanistic Probes for Lipoxygenase and Cyclooxygenase Catalysis1☆ (2000) (11)
A fungal catalase reacts selectively with the 13S fatty acid hydroperoxide products of the adjacent lipoxygenase gene and exhibits 13S-hydroperoxide-dependent peroxidase activity. (2017) (11)
Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine. (2001) (10)
Cytochrome P450-type Hydroxylation and Epoxidation in a Tyrosine-liganded Hemoprotein, Catalase-related Allene Oxide Synthase* (2012) (10)
Lipoxin syntheses by arachidonate 12- and 5-lipoxygenases purified from porcine leukocytes. (1988) (10)
Lipoxygenase metabolism of polyunsaturated fatty acids in oocytes of the frog Xenopus laevis. (1989) (10)
Formation of a Cyclopropyl Epoxide via a Leukotriene A Synthase-related Pathway in an Anaerobic Reaction of Soybean Lipoxygenase-1 with 15S-Hydroperoxyeicosatetraenoic Acid (2010) (10)
Investigation into 9(S)-HPODE-derived allene oxide to cyclopentenone cyclization mechanism via diradical oxyallyl intermediates. (2016) (9)
Mechanistic studies of the dioxygenase and leukotriene synthase activities of the porcine leukocyte 12S-lipoxygenase. (1989) (9)
Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration[S] (2013) (9)
The Thr–His Connection on the Distal Heme of Catalase‐Related Hemoproteins: A Hallmark of Reaction with Fatty Acid Hydroperoxides (2016) (9)
Synthesis of 10(S)-Hydroxyeicosatetraenoic Acid: A Novel Cytochrome P-450 Metabolite of Arachidonic Acid (1996) (9)
The structure and peroxidase activity of a 33‐kDa catalase‐related protein from Mycobacterium avium ssp. paratuberculosis (2009) (9)
Lipoxygenase catalyzed oxygenation of hydroxy fatty acids to lipoxins. (1988) (9)
Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction[S] (2014) (9)
Incorporation of 12(S)-hydroxyeicosatetraenoic acid into the phosphatidylcholine signaling pathway. (1996) (9)
Quantitative aspects of prostacyclin metabolism in humans. (1983) (8)
Quantitative analysis of leukotriene B4 in human serum. (1985) (8)
8R-Lipoxygenase-catalyzed synthesis of a prominent cis-epoxyalcohol from dihomo-γ-linolenic acid: a distinctive transformation compared with S-lipoxygenases[S] (2012) (8)
Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomalla (2002) (8)
Mammalian arachidonate 12-lipoxygenases. (1997) (8)
Novel leukotrienes and lipoxygenase products from arachidonic acid. (1982) (8)
Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function (2020) (8)
Identification of the peroxidation products of 13-hydroxy-gamma-linolenate and 15-hydroxyarachidonate: mechanistic studies on the formation of leukotriene-like diols. (2007) (8)
The 5-lipoxygenase and 15-lipoxygenase of neutrophils and eosinophils. (1985) (7)
Investigations of the biological activity of leukotriene A4 in human polymorphonuclear leukocytes. (1985) (7)
Robust inhibitory effects of conjugated linolenic acids on a cyclooxygenase-related linoleate 10S-dioxygenase: Comparison with COX-1 and COX-2. (2015) (6)
Metabolite Measurement as an Index of Prostaglandin Synthesis in Vivo (1980) (6)
Quantitation of two dinor metabolites of prostacyclin by GC-MS. (1982) (6)
An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere (2019) (6)
The effect of indomethacin on the biosynthesis and metabolism of prostaglandin F2alpha in man. (1978) (6)
1 15-Lipoxygenase Metabolism of 2-Arachidonylglycerol : Generation of a PPAR α Agonist (2002) (5)
Differential effects of lipoxygenase products on FMLP and LTB4 evoked neutrophil aggregation (1985) (5)
Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples. (2021) (5)
Stimulation by lipoxygenase products of superoxide anion production in FMLP-treated neutrophils (1985) (5)
A secondary isotope effect in the lipoxygenase reaction. (1986) (5)
A new method for the determination of the major metabolite of prostaglandin F2alpha in human urine based on stable isotope dilution and gas chromatography-mass spectrometry. (1976) (4)
Stereocontrolled synthesis of four isomeric linoleate triols of relevance to skin barrier formation and function. (2018) (4)
Lipoxygenases: A Chronological Perspective on the Synthesis of S and R Fatty Acid Hydroperoxides (2015) (4)
A Critical Role of Non-active Site Residues on Cyclooxygenase Helices 5 and 6 in the Control of Prostaglandin Stereochemistry at Carbon 15* (2007) (4)
Demonstration of HNE-related aldehyde formation via lipoxygenase-catalyzed synthesis of a bis-allylic dihydroperoxide intermediate. (2013) (3)
Allene Oxide Biosynthesis and Metabolism (1991) (3)
Synthesis and applications of stereospecifically (3)H-labeled arachidonic acids as mechanistic probes for lipoxygenase and cyclooxygenase catalysis. (2000) (3)
On the mechanism of biosynthesis of 5- and 15-series leukotrienes. (1984) (3)
The VX-2 carcinoma: humoral effects and arachidonic acid metabolism. (1980) (3)
Enzymatic lipid peroxidation: a step in the breakdown of mitochondria during the maturation of red blood cells. (1988) (3)
Analysis of 12/15-lipoxygenase metabolism of EPA and DHA with special attention to authentication of docosatrienes (2021) (3)
Dehydrogenase reductase 9 (SDR9C4) and related homologs recognize a broad spectrum of lipid mediator oxylipins as substrates (2021) (2)
S663D Stable-5-LOX in complex with Arachidonic Acid (2012) (2)
Expression and subcellular localization of lipoxygenases in human corneal epithelial cells. (2004) (2)
Role of the conserved distal heme asparagine in coral allene oxide synthase and human catalase (2008) (2)
838 – INFLUENCE OF PREDNISONE AND NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ON PROSTAGLANDIN TURNOVER (1978) (2)
Oxidation of C18 Hydroxy-Polyunsaturated Fatty Acids to Epoxide or Ketone by Catalase-Related Hemoproteins Activated with Iodosylbenzene (2017) (2)
The identification of 5β,7α-dihydroxy-11-oxotetranor-prostane-1, 16-dioic acid as a urinary metabolite of prostaglandin F2α in the rat (1979) (2)
8 S-Lipoxygenase Products Activate Peroxisome Proliferator-activated Receptor a and Induce Differentiation in Murine Keratinocytes 1 (2000) (2)
Quantitation of the major urinary metabolite of PGF2 alpha in the human by GC-MS. (1982) (2)
Dioxygenase and leukotriene A synthase activities of arachidonate 5- and 12-lipoxygenases purified from porcine leukocytes. (1987) (2)
Novel Transformations of HPETEs by Cytochrome P45Os a (1994) (2)
Comparison of the effects of selective inhibition of thromboxane synthase with those of inhibition of the cyclooxygenase enzyme in man. (1984) (2)
Mechanism of the Rearrangement of Vinyl Allene Oxide to 2-Cyclopenten-1-one. (1999) (2)
Derivatization and analysis of leukotrienes by desorption-chemical ionization mass spectrometry at subnanomole level. (1983) (1)
Molecular cloning of an allene oxide synthase : A cytochrome P 450 specialized for the metabolism of fatty acid hydroperoxides ( jasonic acid (2005) (1)
Revising the structure of a new eicosanoid from human platelets to 8,9–11,12-diepoxy-13-hydroxyeicosadienoic acid (2019) (1)
Analysis of cyclooxygenase-substrate interactions using stereospecifically-labeled arachidonic acids. (2002) (1)
Conjugated triene metabolites of arachidonic acid derived from dioxygenation at carbon-15: origin from eosinophil and mechanisms of biosynthesis. (1983) (1)
Allene oxides as intermediates in biosynthesis of ketols and cyclopentenones. (1989) (1)
Specific short-chain aldehydes are cleavage products of the transformation of arachidonic acid to hydroperoxyeicosatetraenoic acids and leukotrienes. (1987) (1)
Inhibitory effects of a novel Val to Thr mutation on the distal heme of human catalase. (2014) (1)
655 Origin and functions of the corneocyte lipid envelope (2018) (1)
Measurement of 5,8,11, 14-icosatetraynoic acid in plasma by gas-liquid chromatography. (1981) (1)
Mechanism of biosynthesis of 11 R- and 12R-hydroxyeicosatetraenoic acids by eggs of the sea urchin (2001) (1)
Prostaglandins (Pgs) in Intrinsic Bronchial Asthma (1977) (1)
Acknowledgment of Guest Editors, 2019 (2019) (1)
Monolayer autoxidation of arachidonic acid to epoxyeicosatrienoic acids as a model of their potential formation in cell membranes (2021) (1)
Systemic synthesis of prostaglandin I2 following sustained infusion of angiotensin II in conscious dogs. (1986) (1)
Non-Cyclooxygenase Prostaglandin Biosynthesis: Formation of PGA 3 Isomers Via an Allene Oxide (1990) (1)
The Precise Structures and Stereochemistry of Trihydroxy-Linoleates Esterified in Human and Porcine Epidermis (2017) (1)
Distinct Sub-cellular Localization of 15-lipoxygenase-1 and -2 in Human Corneal Epithelial Cells (2003) (0)
On the basis for the positional specificity and stereo specificity of lipoxygenases (2002) (0)
Acid metabolism in stimulated murine eosinophils. (1983) (0)
Analysis of cyclooxygenase-substrate interactions using stereospecifically-labeled arachidonic acids (1999) (0)
Application of deuterium labelling in studies of the biosynthesis and metabolism of prostaglandin F2α in man (1978) (0)
The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold (2005) (0)
Role of an 8-Lipoxygenase in the Maturation of Starfish Oocytes (1993) (0)
3P090 Origin of Functional Difference in Tyrosinate-ligated Homologous Enzymes, Coral Allene Oxide Synthase and Catalase (2005) (0)
The structure of an 8R-Lipoxygenase reveals the structural basis for Calcium-regulated membrane binding (2005) (0)
Molecular cloning and characterization of the cDNA for coral cyclooxygenase (1999) (0)
S663A Stable-5-LOX (2012) (0)
773 Purified recombinant PNPLA1 catalyzes the synthesis of acylceramides and acylacids of the mammalian skin barrier (2023) (0)
15-Lipoxygenase-2 in human epithelial cells and its reduced expression in cancer (1999) (0)
718 Identification of lipid-peptide adducts of the 12R-lipoxygenase pathway in human and murine corneocyte lipid envelopes (2023) (0)
Catalytic activity of human 12R-lipoxygenase and its expression in psoriasis and tonsils (1999) (0)
Specific lipoxygenase attack on arachidonate and linoleate esterified in phosphatidylcholine: precedent for an alternative mechanism in activation of icosanoid biosynthesis. (1985) (0)
116 SDR9C7 catalyzes the critical dehydrogenation of acylceramides for skin barrier formation (2021) (0)
8(S)-Lipoxygenase products activate PPARα, induce differentiation and enhance skin tumor development (1999) (0)
Formation of an Allene Oxide (II) from (8R)-8-Hydroperoxyeicosatetraenoic Acid (I) in the Coral Plexaura homomalla (1989) (0)
Studies on the analysis of prostaglandins and their metabolites (1976) (0)
2P078 Interactions between Coral Allene Oxide Synthase and Substrate : Resonance Raman Investigation (2004) (0)
Synthesis of a novel allene oxide from linolenic acid by a mini‐catalase/lipoxygenase fusion protein from the cyanobacterium Acaryochloris marina (2008) (0)
Origin of Functional Difference in Structurally Homologous Enzymes , Coral Allene Oxide Synthase and Catalase ; Resonance Raman Investigation (2005) (0)
Crystal structure of fungal lipoxygenase from Fusarium graminearum. I222 crystal form. (2019) (0)
Challenging the evidence for hepoxilin A3 being a mediator of neutrophil epithelial transmigration. (2020) (0)
Synthesis of (10S)‐Hydroxyeicosatetraenoic Acid (VIII): A Novel Cytochrome P‐450 Metabolite of Arachidonic Acid. (1996) (0)
Crystal structure of fungal lipoxygenase from Fusarium graminearum. P212121 crystal form. (2019) (0)
Mechanism of transformation of 15(S)-hydroperoxyeicosatetraenoic acid to 15-series leukotrienes by purified porcine leukocyte 12-lipoxygenase. (1987) (0)
Crystal structure of fungal lipoxygenase from Fusarium graminearum. Second C2 crystal form. (2019) (0)
Proceedings: Applications of liquid-gel partition chromatography in the prostaglandin field. (1974) (0)
Recombinant PNPLA1 catalyzes the synthesis of acylceramides and acyl acids with selective incorporation of linoleic acid. (2023) (0)
Catalase-Related Allene Oxide Synthase, on a Biosynthetic Route to Fatty Acid Cyclopentenones: Expression and Assay of the Enzyme and Preparation of the 8R-HPETE Substrate. (2018) (0)
Stable-5-Lipoxygenase (2011) (0)
Identification of two amino acids critical for the positional specificity of mouse 8S-lipoxygenase: mutation to the 15-lipoxygenase-2 sequence changes specificity to oxygenation at C-15 (1999) (0)
OF 8 R-LIPOXYGENASE ARACHIDONIC ACID-BINDING SITE Complex with Substrate : THE Crystal Structure of a Lipoxygenase in Protein Structure and Folding : (2014) (0)
Crystal structure of fungal lipoxygenase from Fusarium graminearum. P21 crystal form. (2019) (0)
Two C18 hydroxy-cyclohexenone fatty acids from mammalian epidermis: Potential relation to 12R-lipoxygenase and covalent binding of ceramides. (2023) (0)
The identification of 5beta,7alpha-dihydroxy-11-oxotetranor-prostane-1,16-dioic acid as a urinary metabolite of prostaglandin F2alpha in the rat. (1979) (0)
Systemic PGI2 Synthesis in Man is Decreased during Activation of the Renin-Angiotensin System (1983) (0)
The Eicosanoids Edited by Peter Curtis-Prior (Cambridge Research Institute and Anglia Polytechnic University, UK). John Wiley & Sons, Chichester. 2004. xx + 634 pp. 9 × 11 in. $350.00. ISBN 0-471-48984-0. (2005) (0)
Endoperoksiidide moodustumine rasvhappe epoksiididest lipoksügenaasi poolt katalüüsitud reaktsioonis. Lipoxygenase-assisted formation of endoperoxides from fatty acid epoxides (2015) (0)
Reviewer Acknowledgments (2009) (0)
Crystal structure of fungal lipoxygenase from Fusarium graminearum. C2 crystal form. (2019) (0)
Stereospecific Removal of the D ~ Hydrogen Atom at the 10-Carbon of Arachidonic Acid in the Biosynthesis of Leukotriene & by Human Leukocytes * (2001) (0)
Formation of a Cyclopropyl Eicosanoid via an Allene Oxide in the Coral Plexaura homomalla: Implications for the Biosynthesis of 5,6-trans-Prostaglandin A2. (1989) (0)
Allene oxide synthesis: Novel reaction of cytochrome P450 (1992) (0)

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