Alan Carl Foster
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Biology
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(Suggest an Edit or Addition)Alan Carl Foster's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors (1984) (802)
- Amino acid neurotransmitters and their pathways in the mammalian central nervous system (1983) (642)
- 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. (1988) (510)
- Non-competitive antagonists of excitatory amino acid receptors (1987) (506)
- The novel anticonvulsant MK‐801 binds to the activated state of the N‐methyl‐d‐aspartate receptor in rat brain (1987) (449)
- II: Excitotoxic models for neurodegenerative disorders (1984) (445)
- Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid (1984) (402)
- Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions (2004) (367)
- Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors. (1996) (357)
- Gene expression analyses reveal molecular relationships among 20 regions of the human CNS (2006) (342)
- Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats (2004) (286)
- MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period (1988) (274)
- Excitatory amino acid synaptic mechanisms and neurological function (1986) (231)
- Taking apart NMDA receptors (1987) (200)
- Synaptic localization of kainic acid binding sites (1981) (197)
- On the excitotoxic properties of quinolinic acid, 2,3-piperidine dicarboxylic acids and structurally related compounds (1983) (196)
- Identification of quinolinic acid in rat and human brain tissue (1983) (183)
- Corticotropin Releasing Hormone Type 2 Receptors in the Dorsal Raphe Nucleus Mediate the Behavioral Consequences of Uncontrollable Stress (2003) (182)
- Glutamate- and GABA-based CNS therapeutics. (2006) (182)
- Excitotoxic models for neurodegenerative disorders. (1984) (168)
- 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor. (1992) (157)
- The interaction between MK-801 and receptors for n-methyl-d-aspartate : Functional consequences (1987) (156)
- Role of corticotropin-releasing factor (CRF) receptors in the anorexic syndrome induced by CRF. (2000) (154)
- Pharmacological evidence supporting a role for central corticotropin-releasing factor(2) receptors in behavioral, but not endocrine, response to environmental stress. (2002) (148)
- Systemic administration of MK-801 prevents N-methyl-d-aspartate-induced neuronal degeneration in rat brain (1987) (145)
- Seizure activity and lesions after intrahippocampal quinolinic acid injection (1984) (143)
- Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists. (1997) (132)
- Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative. (1990) (131)
- Synthesis of Quinolinic Acid by 3‐Hydroxyanthranilic Acid Oxygenase in Rat Brain Tissue In Vitro (1986) (127)
- High-Affinity CRF1 Receptor Antagonist NBI-34041: Preclinical and Clinical Data Suggest Safety and Efficacy in Attenuating Elevated Stress Response (2007) (126)
- Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. (1991) (122)
- Chloride and calcium ions reveal a pharmacologically distinct population of L-glutamate binding sites in synaptic membranes: correspondence between biochemical and electrophysiological data (1982) (121)
- Behavioral and neuroendocrine effects of the selective CRF2 receptor agonists urocortin II and urocortin III (2004) (118)
- 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor. (1994) (115)
- Comparison of L-[3H]glutamate, D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain. (1987) (108)
- Studies on the disposition of quinolinic acid after intracerebral or systemic administration in the rat (1984) (106)
- Urocortin, corticotropin releasing factor-2 receptors and energy balance. (2001) (104)
- Indiplon Is a High-Affinity Positive Allosteric Modulator with Selectivity for α1 Subunit-Containing GABAA Receptors (2006) (104)
- Pharmacological specificity of synthetic peptides as antagonists at tachykinin receptors (1988) (102)
- Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion. (1998) (100)
- Displacement of insulin-like growth factors from their binding proteins as a potential treatment for stroke. (1998) (95)
- Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy. (1999) (95)
- The regulation of feeding and metabolic rate and the prevention of murine cancer cachexia with a small-molecule melanocortin-4 receptor antagonist. (2005) (88)
- Quinolinic acid phosphoribosyltransferase in human and rat brain: Activity in Huntington's disease and in quinolinate-lesioned rat striatum (1985) (85)
- 2-Carboxytetrahydroquinolines. Conformational and stereochemical requirements for antagonism of the glycine site on the NMDA receptor. (1992) (78)
- Characterization of the binding of [3H]L-689,560, an antagonist for the glycine site on the N-methyl-D-aspartate receptor, to rat brain membranes. (1992) (76)
- Quinolinic Acid Phosphoribosyltransferase in Rat Brain (1985) (75)
- Glutamate and aspartate binding sites are enriched in synaptic junctions isolated from rat brain (1981) (75)
- Chloride and calcium ions separate L-glutamate receptor populations in synaptic membranes. (1983) (70)
- Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain. (1992) (69)
- 3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. (1993) (68)
- Anticonvulsant activity of glycine-site NMDA antagonists. 2. trans 2-carboxy-4-substituted tetrahydroquinolines. (1993) (68)
- Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice. (2007) (64)
- In Vivo Pharmacological Characterization of Indiplon, a Novel Pyrazolopyrimidine Sedative-Hypnotic (2004) (61)
- Central infusion of the melanocortin receptor antagonist agouti-related peptide (AgRP(83-132)) prevents cachexia-related symptoms induced by radiation and colon-26 tumors in mice (2007) (58)
- Neuroprotective Effects of Insulin-Like Growth Factor-Binding Protein Ligand Inhibitors in Vitro and in Vivo (2003) (58)
- Identification of differentially expressed genes induced by transient ischemic stroke. (2002) (57)
- Glycine maintains excitement (1989) (57)
- 4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity. (1997) (51)
- Pre-and peristroke treatment with the adenosine kinase inhibitor, 5′-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats (1996) (50)
- Corticotropin‐releasing factor receptor 1‐deficient mice show decreased anxiety and colonic sensitivity (2007) (50)
- Characterization of the Interaction of Indiplon, a Novel Pyrazolopyrimidine Sedative-Hypnotic, with the GABAA Receptor (2004) (50)
- Characterization of Novel Aryl-Ether, Biaryl, and Fluorene Aspartic Acid and Diaminopropionic Acid Analogs as Potent Inhibitors of the High-Affinity Glutamate Transporter EAAT2 (2005) (48)
- [3H]MK‐801 Binding to N‐Methyl‐d‐Aspartate Receptors Solubilized from Rat Brain: Effects of Glycine Site Ligands, Polyamines, Ifenprodil, and Desipramine (1991) (43)
- D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures (2016) (42)
- An investigation of the mechanisms of delayed neurodegeneration caused by direct injection of quinolinate into the rat striatum in vivo (1991) (42)
- Allosteric modulation of the glutamate site on the NMDA receptor by four novel glycine site antagonists. (1995) (41)
- Role of the GLT‐1 subtype of glutamate transporter in glutamate homeostasis: the GLT‐1‐preferring inhibitor WAY‐855 produces marginal neurotoxicity in the rat hippocampus (2005) (40)
- The expression of excitatory amino acid binding sites during neuritogenesis in the developing rat cerebellum. (1990) (38)
- Identification of Synapse Specific Components: Synaptic Glycoproteins, Proteins, and Transmitter Binding Sites (1981) (37)
- An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum (1993) (36)
- Regulation of glutamate receptors: possible role of phosphatidylserine (1982) (36)
- Endogenous Amino Acid Release from Rat Cerebellum In Vitro (1980) (35)
- [3H]Glycine uptake in rat hippocampus: kinetic analysis and autoradiographic localization (1992) (35)
- MK-801, NMDA receptors and ischaemia-induced neurodegeneration (1987) (34)
- Characterization of Quinolinic Acid Phosphoribosyltransferase in Human Blood and Observations in Huntington's Disease (1985) (32)
- Effects of a selective agonist and antagonist of CRF2 receptors on cardiovascular function in the rat. (2003) (31)
- 4-{(2R)-[3-Aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thienyl)ethylaminomethyl]phenyl}piperazine as a potent and selective melanocortin-4 receptor antagonist--design, synthesis, and characterization. (2004) (29)
- Over‐expression of the human EAAT2 glutamate transporter within neurons of mouse organotypic hippocampal slice cultures leads to increased vulnerability of CA1 pyramidal cells (2005) (28)
- Neurobiology. Taking apart NMDA receptors. (1987) (28)
- Pharmacological characterization of threo‐3‐methylglutamic acid with excitatory amino acid transporters in native and recombinant systems (2001) (28)
- Expression profile of the copper homeostasis gene, rAtox1, in the rat brain (1999) (27)
- A radioenzymatic assay for quinolinic acid. (1986) (27)
- Body Weight Regulation by Selective MC4 Receptor Agonists and Antagonists (2003) (26)
- Quisqualate receptor antagonists (1988) (26)
- Molecular interactions of nonpeptide agonists and antagonists with the melanocortin-4 receptor. (2005) (25)
- BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss (2019) (25)
- Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists (1993) (25)
- Expression of rat insulin-like growth factor binding protein-6 in the brain, spinal cord, and sensory ganglia. (2000) (25)
- Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines. (2005) (25)
- Autoradiographical analysis of excitatory amino acid binding sites in rat hippocampus during the development of hippocampal kindling (1990) (25)
- L-glutamate and l-aspartate bind to separate sites in rat brain synaptic membranes (1981) (24)
- Melanocortin-4 receptor antagonists as potential therapeutics in the treatment of cachexia. (2007) (24)
- The pharmacological specificity of N‐methyl‐d‐aspartate receptors in rat cerebral cortex: correspondence between radioligand binding and electrophysiological measurements (1991) (24)
- A Novel Cell-Based Assay for G-Protein-Coupled Receptor-Mediated Cyclic Adenosine Monophosphate Response Element Binding Protein Phosphorylation (2006) (22)
- Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor. (2004) (22)
- Comparison of the binding of radiolabelled neurokinin A and eledoisin in rat cortex synaptic membranes (1988) (22)
- Plasma and CSF levels of dizocilpine (MK-801) required for neuroprotection in the quinolinate-injected rat striatum. (1991) (21)
- Structure-activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor. (2004) (21)
- Neuroprotective Effects of the CRF1 Antagonist R121920 after Permanent Focal Ischemia in the Rat (2001) (20)
- Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists. (2008) (20)
- Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia. (2007) (19)
- Structure-activity relationships of l-glutamate receptor ligands: Role of the ω-acidic terminal (1982) (19)
- The Effect of GP683, an Adenosine Kinase Inhibitor, on the Desflurane Anesthetic Requirement in Dogs (1997) (19)
- Corticotropin-releasing factor: effect on cerebral blood flow in physiologic and ischaemic conditions (2005) (19)
- NMDA receptors assessed by autoradiography with [3H]L-689,560 are present but not enriched on corticofugal-projecting pyramidal neurones (1992) (19)
- A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice. (2005) (18)
- Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor. (2006) (18)
- Multiple Receptors and Binding Sites for Tachykinins (1987) (18)
- Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. (2008) (18)
- MC4 receptor antagonists: a potential treatment for cachexia. (2005) (16)
- Derivatives of 1-hydroxy-3-aminopyrrolidin-2-one (HA-966). Partial agonists at the glycine site of the NMDA receptor (1993) (16)
- Phenylglycine analogs are inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 and enhance NMDA receptor-mediated LTP in rat visual cortex slices (2017) (16)
- 3′‐(Arylmethyl)‐ and 3′‐(Aryloxy)‐3‐phenyl‐4‐hydroxyquinolin‐2(1H)‐ ones: Orally Active Antagonists of the Glycine Site on the NMDA Receptor. (2010) (15)
- Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor. (2007) (15)
- The Neurodegenerative Properties Of Intracerebral Quinolinic Acid And Its Structural Analog Cis-2,3-Piperidine Dicarboxylic Acid (1983) (15)
- Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors. (2008) (15)
- Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor. (2008) (14)
- Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor. (2007) (13)
- Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor. (2007) (13)
- Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors. (2008) (13)
- Blockade of excitatory amino acid transporters in the rat hippocampus results in enhanced activation of group I and group III metabotropic glutamate receptors (2003) (12)
- Phenylguanidines as selective nonpeptide melanocortin-5 receptor antagonists. (2004) (12)
- Acidic amino acid receptor nomenclature: time for change (1988) (12)
- Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity. (2007) (11)
- Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines. (2005) (11)
- Propionylpiperazines as human melanocortin-4 receptor ligands. (2006) (10)
- 2-carboxy indolines and indoles as potential glycine/NMDA antagonists: effect of five-membered ring conformation on affinity. (1992) (10)
- The glycine site on the NMDA receptor: pharmacology and involvement in NMDA receptor-mediated neurodegeneration. (1990) (10)
- Discrimination of Excitatory Amino Acid Receptor Sub-types Using Radioligand Binding Techniques (1986) (10)
- Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain. (2008) (9)
- Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands. (2008) (9)
- Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors. (2008) (9)
- Inhibitors of the Neutral Amino Acid Transporters ASCT1 and ASCT2 Are Effective in In Vivo Models of Schizophrenia and Visual Dysfunction (2018) (8)
- Structure-activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor. (2005) (8)
- Optimization of piperazinebenzylamines with a N-(1-methoxy-2-propyl) side chain as potent and selective antagonists of the human melanocortin-4 receptor. (2005) (8)
- Therapeutic potential of NMDA receptor antagonists as neuroprotective agents. (1990) (8)
- Activity of the enantiomers of erythro‐3‐hydroxyaspartate at glutamate transporters and NMDA receptors (2016) (7)
- Targeting melanocortin receptors for the treatment of obesity (2006) (7)
- Autoradiographical evaluation of [3H]glycine uptake in rat forebrain: Cellular localization in the hippocampus (1993) (7)
- Ischemic preconditioning reduces infarct volume after subdural hematoma in the rat (2002) (6)
- trans-2-Carboxy-4-substituted Tetrahydroquinolines. Potent Glycine- Site NMDA Receptor Antagonists. (1991) (6)
- Structure-activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor. (2005) (6)
- Physiology and pathophysiology of excitatory amino acid neurotransmitter systems in relation to Alzheimer's disease. (1990) (5)
- A comment on the classification and nomenclature of phencyclidine and sigma receptor sites (1988) (5)
- Regulation of endogenous adenosine levels in the CNS: potential for therapy in stroke, epilepsy and pain. (1994) (5)
- 6.04 – Anxiety (2007) (5)
- 3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically Active Anticonvulsants Acting by Antagonism at the Glycine Site of the N- Methyl-D-aspartate Receptor Complex. (1994) (5)
- 4‐Substituted‐3‐phenylquinolin‐2(1H)‐ones: Acidic and Nonacidic Glycine Site N‐Methyl‐D‐aspartate Antagonists with in vivo Activity. (1997) (5)
- Neurobiology. Glycine maintains excitement. (1989) (4)
- Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor. (2006) (4)
- Quinolinate And Kynurenate, Two Endogenous Tryptophan Metabolites With Potential Links To Epileptic Disorders (1984) (4)
- A neurotrophic approach to treating hearing loss: Translation from animal models to clinical proof-of-concept. (2022) (4)
- Involvement of excitatory amino acid receptors in the mechanisms underlying excitotoxic phenomena. (1986) (4)
- 3-aminoglutarate is a “silent” false transmitter for glutamate neurons (2015) (4)
- STUDIES OF QUINOLINIC ACID METABOLISM IN RAT BRAIN (1984) (4)
- Effects of 3-aminoglutarate, a “silent” false transmitter for glutamate neurons, on synaptic transmission and epileptiform activity (2015) (4)
- Restoration of visual performance by d-serine in models of inner and outer retinal dysfunction assessed using sweep VEP measurements in the conscious rat and rabbit (2016) (4)
- Glutamate- and GABA-based drugs: the next wave of CNS therapeutics? (2006) (3)
- Biochemical and morphological aspects of kainic acid injection into rat cerebellum [proceedings]. (1979) (2)
- Hearing loss: The final frontier of pharmacology (2022) (2)
- Therapeutic neuroprotection by an engineered neurotrophin designed to broadly activate Trk-receptors and to circumvent p75 receptors. (2021) (2)
- Synthesis of Piperazinephen-1-ylethylamines as Potent and Selective Antagonists of the Human Melanocortin-4 Receptor (2006) (2)
- Structure--activity relationships of L-glutamate receptor ligands: role of the omega-acidic terminal. (1982) (1)
- Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor (2021) (1)
- Pharmacological Enhancement of LTP in Primary Visual Cortex via activation of Alpha 2a/c Adrenergic Receptors (2012) (0)
- An apparatus for examining an enclosure in metal magnetic (1976) (0)
- Glutamic acid: High-affinity binding tocerebellar membranes (1977) (0)
- Neurobiology. Quisqualate receptor antagonists. (1988) (0)
- Chapter 10 Glutamate receptors (1993) (0)
- Geraet for inspection of intake trim of a vessel (1976) (0)
- Neuromuscular spedfldty: pathflnding by identified motor growth cones in a vertebrate embryo (1988) (0)
- Adenosine-Based Approaches to the Treatment of Neurodegenerative Disease (2002) (0)
- Transporter inhibitors D-serine as pharmaceutical compositions for the treatment of disorders of the central nervous system (2012) (0)
- AN ADVANCED TRAVELLER INFORMATION SYSTEM FOR THE CHRYSLER TECHNOLOGY CENTER (1996) (0)
- Determination off the potencies of the R-(+) and S-(−) enantiomers off HA-966 as antagonists of the glycine site on the NMDA receptor complex (1990) (0)
- 933 – L-3H-GLUTAMATE BINDING TO CEREBELLAR MEMBRANE PREPARATIONS (1978) (0)
- System for gefaessuntersuchung (1976) (0)
- SHORT COMMUNICATION Over-expression of the human EAAT2 glutamate transporter within neurons of mouse organotypic hippocampal slice cultures leads to increased vulnerability of CA1 pyramidal cells (2005) (0)
- Glutamic acid: high-affinity binding to cerebellar membranes [proceedings]. (1977) (0)
- Remote controlled device for inspecting connections sodas (1976) (0)
- Fjerrmanovrerad apparatus for inspecting the connection between a conduit and Veggen of a kerl (1976) (0)
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