Alan Fairlamb
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British biochemist
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Biology
Alan Fairlamb's Degrees
- Bachelors Biochemistry University of Oxford
Why Is Alan Fairlamb Influential?
(Suggest an Edit or Addition)According to Wikipedia, Alan Hutchinson Fairlamb, CBE, FRSE, FLS, FMedSci, FRSB is a Wellcome Trust Principal Research Fellow and Professor of Biochemistry in the Division of Biological Chemistry and Drug Discovery at the School of Life Sciences, University of Dundee, Scotland. From 2006-2011 he was a member of the Scientific and Technical Advisory Committee of the Special Programme for Research and Training in Tropical Diseases -- an independent global programme of scientific collaboration co-sponsored by UNICEF, UNDP, the World Bank and WHO. Currently he is a member of the governing board of the Tres Cantos Open Lab Foundation, whose aim is to accelerate the discovery and development of medicines to tackle diseases of the developing world in an open collaborative manner.
Alan Fairlamb's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Genome sequence of the human malaria parasite Plasmodium falciparum (2002) (4255)
- The Genome of the African Trypanosome Trypanosoma brucei (2005) (1633)
- Drug Resistance in Leishmaniasis (2006) (914)
- Metabolism and functions of trypanothione in the Kinetoplastida. (1992) (715)
- Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids. (1985) (614)
- Kinetoplastids: related protozoan pathogens, different diseases. (2008) (506)
- Chemotherapy of human African trypanosomiasis: current and future prospects. (2003) (333)
- Arsenical-resistant trypanosomes lack an unusual adenosine transporter (1993) (331)
- Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress (2000) (323)
- A novel multiple-stage antimalarial agent that inhibits protein synthesis (2015) (315)
- Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need (2017) (297)
- Dual Action of Antimonial Drugs on Thiol Redox Metabolism in the Human Pathogen Leishmania donovani* (2004) (289)
- Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages (1997) (286)
- N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness (2010) (264)
- Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells (2003) (233)
- Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases. (1986) (229)
- Uptake of Diamidine Drugs by the P2 Nucleoside Transporter in Melarsen-sensitive and -resistant Trypanosoma brucei brucei(*) (1995) (219)
- In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei. (1987) (190)
- Structure of trypanothione reductase from Crithidia fasciculata at 2.6 A resolution; enzyme-NADP interactions at 2.8 A resolution. (1994) (189)
- Trypanothione is the primary target for arsenical drugs against African trypanosomes. (1989) (186)
- Trypanothione reductase from Trypanosoma cruzi (1987) (171)
- Ovothiol and trypanothione as antioxidants in trypanosomatids. (2001) (163)
- Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors. (1999) (158)
- Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival. (1998) (156)
- "Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease. (1988) (154)
- Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents (2003) (153)
- The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins. (2000) (144)
- The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis (2012) (143)
- The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes. (1999) (137)
- Target assessment for antiparasitic drug discovery. (2007) (129)
- Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures. (1992) (129)
- Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids. (1985) (126)
- Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs. (1998) (123)
- Surface receptors and transporters of Trypanosoma brucei. (1998) (123)
- Novel biochemical pathways in parasitic protozoa (1989) (122)
- Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay (2013) (121)
- Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials. (1995) (121)
- Carbohydrate metabolism in African trypanosomes, with special reference to the glycosome. (1986) (121)
- Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis (2010) (117)
- Drug resistance in eukaryotic microorganisms (2016) (115)
- A Single Enzyme Catalyses Formation of Trypanothione from Glutathione and Spermidine in Trypanosoma cruzi * (2002) (110)
- Cloning, expression and functional characterisation of a peroxiredoxin from the potato cyst nematode Globodera rostochiensis. (2000) (107)
- Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography (2011) (107)
- Identification and characterisation of a functional peroxidoxin from Leishmania major. (1998) (106)
- Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony (2007) (106)
- Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors (2011) (105)
- Levels of polyamines, glutathione and glutathione-spermidine conjugates during growth of the insect trypanosomatid Crithidia fasciculata. (1988) (104)
- Isolation and characterization of kinetoplast DNA from bloodstream form of Trypanosoma brucei (1978) (103)
- Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effect on respiration and growth rate in vivo. (1980) (102)
- Target Validation: Linking Target and Chemical Properties to Desired Product Profile (2011) (99)
- Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei. (1987) (98)
- Active site of trypanothione reductase. A target for rational drug design. (1992) (97)
- Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals. (1994) (97)
- Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution. (1993) (96)
- New approach to screening drugs for activity against African trypanosomes (1977) (96)
- Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism. (1992) (96)
- One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening (2009) (95)
- Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase. (2003) (94)
- The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 Å resolution (1996) (87)
- Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition (2019) (87)
- Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities*S⃞ (2008) (83)
- Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata. (1987) (82)
- A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major. (2004) (82)
- Two Interacting Binding Sites for Quinacrine Derivatives in the Active Site of Trypanothione Reductase (2004) (81)
- Differential toxicity of antimonial compounds and their effects on glutathione homeostasis in a human leukaemia monocyte cell line. (2006) (80)
- Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei. (2001) (80)
- An improved technique for the cultivation of Plasmodium falciparum in vitro without daily medium change. (1985) (79)
- Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress. (1993) (79)
- Trypanothione biosynthesis in Leishmania major. (2005) (79)
- Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis (2018) (78)
- A 7.1 kb linear DNA molecule of Theileria parva has scrambled rDNA sequences and open reading frames for mitochondrially encoded proteins. (1994) (76)
- Roles of Trypanothione S-Transferase and Tryparedoxin Peroxidase in Resistance to Antimonials (2008) (76)
- Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine. (2001) (75)
- Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome. (2005) (74)
- Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates. (2010) (74)
- A new expression vector for Crithidia fasciculata and Leishmania. (2002) (73)
- Trypanothione Reductase from Leishmania donovani (1995) (73)
- A comparative study of methylglyoxal metabolism in trypanosomatids (2009) (72)
- Melarsoprol Resistance in African Trypanosomiasis. (2018) (71)
- Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania (2016) (71)
- Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis (2019) (70)
- Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods (2009) (70)
- Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi. (1994) (69)
- Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis. (2006) (69)
- Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei (2015) (68)
- Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis (2010) (66)
- Biochemical changes associated with alpha-difluoromethylornithine uptake and resistance in Trypanosoma brucei. (1987) (66)
- Characterization of protein Ser/Thr phosphatases of the malaria parasite, Plasmodium falciparum: inhibition of the parasitic calcineurin by cyclophilin-cyclosporin complex. (1999) (65)
- The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis (2016) (65)
- Leishmania major Elongation Factor 1B Complex Has Trypanothione S-Transferase and Peroxidase Activity* (2004) (65)
- Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase. (1995) (65)
- Diamine auxotrophy may be a universal feature of Trypanosoma cruzi epimastigotes. (1997) (65)
- Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes (2008) (64)
- Regulation of a high-affinity diamine transport system in Trypanosoma cruzi epimastigotes. (1996) (63)
- Trypanothione S-Transferase Activity in a Trypanosomatid Ribosomal Elongation Factor 1B* (2004) (63)
- Specificity of the trypanothione‐dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme (2006) (63)
- Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis (2013) (61)
- The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis (2013) (61)
- Characterisation of pentamidine-resistant Trypanosoma brucei brucei. (1995) (61)
- Norspermidine Is Not a Self-Produced Trigger for Biofilm Disassembly (2014) (61)
- Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis (2009) (60)
- Properties of trypanothione synthetase from Trypanosoma brucei. (2003) (59)
- Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate (2006) (58)
- The biosynthesis of trypanothione and N1-glutathionylspermidine in Crithidia fasciculata. (1986) (57)
- Bis(glutathionyl)spermine and Other Novel Trypanothione Analogues in Trypanosoma cruzi* (2003) (56)
- Future prospects for the chemotherapy of human trypanosomiasis. 1. Novel approaches to the chemotherapy of trypanosomiasis. (1990) (56)
- Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity (2009) (56)
- Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei (2009) (55)
- Purification of glutathionylspermidine and trypanothione synthetases from crithidia fasciculata (1992) (55)
- Chemical Validation of Trypanothione Synthetase (2009) (54)
- Trypanosoma brucei: suramin and other trypanocidal compounds' effects on sn-glycerol-3-phosphate oxidase. (1977) (53)
- Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice (2010) (52)
- Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the Indian Subcontinent? (2011) (51)
- Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy (2016) (50)
- Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme. (1987) (50)
- Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation (2012) (50)
- MYST Family Histone Acetyltransferases in the Protozoan Parasite Toxoplasma gondii (2005) (49)
- Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei (2003) (49)
- Trypanothione-dependent glyoxalase I in Trypanosoma cruzi. (2006) (49)
- Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiopen-4,9-quinones. (1997) (48)
- Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi☆ (2010) (48)
- Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis (2014) (47)
- Lipoprotein lipase suppression in 3T3‐L1 cells by a haematoprotozoan‐induced mediator from peritoneal exudate cells (1984) (47)
- Development of a Novel Virtual Screening Cascade Protocol to Identify Potential Trypanothione Reductase Inhibitors (2009) (46)
- Bimane cyclic esters, possible stereologues of trypanothione as antitrypanosomal agents. Bimanes 29 (1995) (46)
- Glutathionylspermidine metabolism in Escherichia coli. (1995) (45)
- Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 (2010) (45)
- Detailed characterization of a cyclophilin from the human malaria parasite Plasmodium falciparum. (1998) (44)
- Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata. (1998) (44)
- Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major* (2011) (44)
- High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. (2007) (44)
- Biochemistry of trypanosomiasis and rational approaches to chemotherapy (1982) (43)
- Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening. (2007) (43)
- Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata. (2002) (43)
- Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase (2009) (42)
- Trypanosoma Cruzi trypanothione reductase is inactivated by peroxidase-generated phenothiazine cationic radicals (2001) (42)
- Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors (2011) (42)
- Interactions between immunity and chemotherapy in the treatment of the trypanosomiases and leishmaniases (1992) (42)
- Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog*♦ (2013) (42)
- Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani (2018) (41)
- Molecular characterization of the trypanothione reductase gene from Crithidia fasciculata and Trypanosoma brucei: comparison with other flavoprotein disulphide oxidoreductases with respect to substrate specificity and catalytic machanism (1992) (40)
- Trypanothione metabolism: a chemotherapeutic target in trypanosomatids. (1987) (39)
- Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase (2016) (39)
- Arsenic Exposure and Outcomes of Antimonial Treatment in Visceral Leishmaniasis Patients in Bihar, India: A Retrospective Cohort Study (2015) (39)
- Synthesis of N-benzyloxycarbonyl-L-cysteinylglycine 3-dimethylaminopropylamide disulfide: a cheap and convenient new assay for trypanothione reductase. (1991) (38)
- Subcellular distribution of trypanothione reductase in bloodstream and procyclic forms of Trypanosoma brucei. (1991) (38)
- Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine. (1997) (37)
- The interaction of arsenical drugs with dihydrolipoamide and dihydrolipoamide dehydrogenase from arsenical resistant and sensitive strains of Trypanosoma brucei brucei. (1992) (37)
- An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes. (1998) (37)
- The High Resolution Crystal Structure of RecombinantCrithidia fasciculata Tryparedoxin-I* (1999) (37)
- The three-dimensional structure of a Plasmodium falciparum cyclophilin in complex with the potent anti-malarial cyclosporin A. (2000) (36)
- Arsenical-resistant trypanosomes lack an unusual adenosine transporter (1993) (36)
- The structure, organization, and expression of the Leishmania donovani gene encoding trypanothione reductase. (1994) (36)
- Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis. (2018) (35)
- A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes (2012) (35)
- Methylglyoxal metabolism in trypanosomes and leishmania (2011) (34)
- A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major (2007) (34)
- Metabolic pathway analysis in trypanosomes and malaria parasites. (2002) (34)
- Future prospects for the chemotherapy of Chagas' disease. (1999) (34)
- Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata. (1990) (34)
- Polyamine and pentamidine metabolism in African trypanosomes. (1993) (32)
- The isolation and characterisation of particulate sn-glycerol-3-phosphate oxidase from Trypanosoma brucei (1977) (31)
- Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome (2015) (31)
- Specificity of Ethanolamine Transport and Its Further Metabolism in Trypanosoma brucei(*) (1995) (31)
- Transport of ethanolamine and its incorporation into the variant surface glycoprotein of bloodstream forms of Trypanosoma brucei. (1985) (30)
- Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus. (1998) (30)
- Extrachromosomal, homologous expression of trypanothione reductase and its complementary mRNA in Trypanosoma cruzi. (1996) (30)
- Properties of melarsamine hydrochloride (Cymelarsan) in aqueous solution (1994) (30)
- TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei (2014) (30)
- Refinement of techniques for the propagation of Leishmania donovani in hamsters. (2006) (28)
- Inhibitor studies on particulate sn-glycerol-3-phosphate oxidase from Trypanosoma brucei (1977) (28)
- Bis-Acridines as Lead Antiparasitic Agents: Structure-Activity Analysis of a Discrete Compound Library In Vitro (2007) (28)
- Trypanosoma brucei: maintenance of concentrated suspensions of bloodstream trypomastigotes in vitro using continuous dialysis for measurement of endocytosis. (1980) (28)
- Uptake of the nitroimidazole drug megazol by African trypanosomes. (2000) (27)
- Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome (2012) (27)
- Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism* (2011) (27)
- Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products. (2006) (26)
- Characterization of kinetoplast DNA networks from the insect trypanosome Crithidia luciliae. (1977) (25)
- Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase (2014) (25)
- Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase (2010) (25)
- Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase (2010) (25)
- PHOSPHONIC ACID AND PHOSPHINIC ACID TRIPEPTIDES AS INHIBITORS OF GLUTATHIONYLSPERMIDINE SYNTHETASE (1996) (25)
- Properties of Phosphoenolpyruvate Mutase, the First Enzyme in the Aminoethylphosphonate Biosynthetic Pathway in Trypanosoma cruzi* (2003) (24)
- Alternate metabolic pathways in protozoan energy metabolism. (1981) (23)
- Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy (2013) (23)
- Trypanothione metabolism and rational approaches to drug design. (1990) (23)
- ATP-dependent ligases in trypanothione biosynthesis – kinetics of catalysis and inhibition by phosphinic acid pseudopeptides (2008) (23)
- A simple magnetic method for the purification of malarial pigment. (1984) (22)
- Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity. (2019) (22)
- The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I. (1999) (22)
- Synthesis of the trypanosomatid metabolites trypanothione, and N1-mono- and N8-mono-glutathionylspermidine (1986) (22)
- Entamoeba histolytica lacks trypanothione metabolism. (1999) (21)
- Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase (2016) (21)
- Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani (2017) (20)
- Triclosan is minimally effective in rodent malaria models (2011) (20)
- Metabolism of Trypanothione and Glutathionylspermidine in Trypanosomatids (1987) (20)
- Arsenic, antimony, and Leishmania: has arsenic contamination of drinking water in India led to treatment- resistant kala-azar? (2015) (20)
- Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases (2008) (20)
- Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase. (2003) (19)
- Molecular characterization and expression of Onchocerca volvulus glutathione reductase. (1997) (19)
- Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study. (2018) (19)
- Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei (2014) (19)
- The N-myristoylome of Trypanosoma cruzi (2016) (19)
- The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei* (2016) (18)
- Regiocontrolled synthesis of the macrocyclic polyamine alkaloid ( + )-lunarine, a time-dependent inhibitor of trypanothione reductase (2002) (18)
- Initiating a crystallographic study of trypanothione reductase. (1990) (18)
- Computer assisted design of potentially active anti-trypanosomal compounds (2002) (17)
- Quinol derivatives as potential trypanocidal agents (2012) (17)
- Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani. (2000) (17)
- Inhibition of polyamine biosynthesis in Crithidia fasciculata by D,L-α-difluoromethylornithine and D,L-α-difluoromethylarginine (1991) (16)
- 8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases. (2018) (16)
- Differential susceptibility of filarial and human erythrocyte glutathione reductase to inhibition by the trivalent organic arsenical melarsen oxide. (1995) (16)
- Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals (2018) (16)
- Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group. (2002) (16)
- Fexinidazole for the treatment of human African trypanosomiasis. (2019) (15)
- 8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase. (2003) (15)
- Screening a protein kinase inhibitor library against Plasmodium falciparum (2017) (15)
- Polyamine metabolism in trypanosomes. (1997) (15)
- Cloning of a pyruvate phosphate dikinase from Trypanosoma cruzi. (2001) (14)
- Enzymatic Inhibitory Activity and Trypanocidal Effects of Extracts and Compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham. (2008) (14)
- Very Short and Efficient Syntheses of the Spermine Alkaloid Kukoamine A and Analogs Using Isolable Succinimidyl Cinnamates (2005) (14)
- Characterization of the peptide substrate specificity of glutathionylspermidine synthetase from Crithidia fasciculata. (1997) (14)
- Inhibition of Leishmania Species by α-Difluoromethylornithine (1989) (14)
- Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: substitution of the glycine part. (2002) (14)
- Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead (2002) (13)
- Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: potential rational drug design lead frameworks (2001) (13)
- Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis (2018) (13)
- Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay (2014) (13)
- Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity. (2015) (12)
- Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need (2018) (12)
- The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani (2020) (12)
- Corrigendum: Anti-trypanosomatid drug discovery: An ongoing challenge and a continuing need (Nature Reviews Microbiology (2017) 15 (217-231) DOI: 10.1038/nrmicro.2016.193) (2017) (12)
- Cytochrome P450 in trypanosomatids. (1993) (12)
- Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases (2016) (11)
- A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism (2018) (10)
- Chloroquine resistance is not associated with drug metabolism in Plasmodium falciparum. (1995) (10)
- Comparative genomics of trypanosome metabolism. (2007) (10)
- Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I. (2005) (10)
- Rational design of peptide-based inhibitors of trypanothione reductase as potential antitrypanosomal drugs (1994) (10)
- An improved method for the estimation of suramin in plasma and trypanosome samples. (1980) (9)
- Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease. (2013) (9)
- Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties. (2020) (9)
- Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials (2016) (9)
- Antitrypanosomatid Pharmacomodulation at Position 3 of the 8‐Nitroquinolin‐2(1H)‐one Scaffold Using Palladium‐Catalysed Cross‐Coupling Reactions (2018) (8)
- 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi. (2020) (8)
- Trypanosoma cruzi trypanothione reductase. Crystallization, unit cell dimensions and structure solution. (1993) (8)
- Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis (2016) (8)
- Synthesis and antitrypanosomal evaluation of some thiazole-containing amino acids and peptides (1993) (8)
- Macrocyclic polyamine lactam synthesis by diphenyl ether closure of 23-, 24- and 28-membered rings (1998) (8)
- Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488 (2011) (7)
- Vector-borne diseases series Antitrypanosomatid drug discovery: an ongoing challenge and a continuing need (2017) (7)
- The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of gamma-glutamyl-modified substrate analogues. (1993) (7)
- Infectious disease: Genomics decodes drug action (2012) (7)
- Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase (2020) (7)
- Antimicrobial drug discovery. (2011) (7)
- The determination of polyamines and amino acids by a fluorescamine-HPLC method. (1998) (7)
- Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major. (2006) (6)
- The role of glutathionylspermidine and trypanothione in regulation of intracellular spermidine levels during growth of Crithidia fasciculata. (1988) (6)
- High-performance liquid chromatographic method for the separation and quantitative estimation of anti-parasitic melaminophenyl arsenical compounds. (1994) (6)
- Trypanothione metabolism in the chemotherapy of leishmaniasis and trypanosomiasis. (1991) (6)
- A study of glycerophosphate oxidase in Trypanosoma brucei (1975) (6)
- Lead optimization of a pyrazole sulfonamide series of trypanosoma brucei N myristoyltransferase inhibitors (2014) (6)
- Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial (2021) (6)
- Cell disruption and subcellular fractionation of Trypanosoma brucei. (1974) (5)
- Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes. (2016) (5)
- The interaction of trypanocidal drugs with polyamine and trypanothione metabolism. (1990) (5)
- Drugs against parasitic diseases: R&D methodologies and issues, discoveries and drug development. (2001) (5)
- Fluphenazine photoaffinity labelling of binding sites for phenothiazine inhibitors of trypanothione reductase (1996) (5)
- Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity. (2021) (5)
- [Inactivation of Trypanosoma cruzi trypanothione reductase by phenothiazine cationic free radicals]. (2001) (5)
- Purification of glutathione reductase from muscle of the adult parasitic nematode Ascaris suum. (1992) (5)
- New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi (2020) (5)
- Metabolism and Functions of Trypanothione with Special Reference to Leishmaniasis (1989) (5)
- Crystallization of RecombinantCrithidia fasciculataTryparedoxin (1999) (5)
- The trypanothione reductase gene of Leishmania donovani. (1990) (5)
- Diamine auxotrophy in a eukaryotic parasite. (1998) (4)
- Renewed strategies for drug development against parasitic diseases. (1999) (4)
- Inhibition of trypanothione reductase and glutathione reductase by ferrocenic 4-aminoquinoline ureas (2008) (4)
- Characterisation of a putative glutamate 5‐kinase from Leishmania donovani (2018) (4)
- Inhibition of polyamine biosynthesis in Crithidia fasciculata by D,L-alpha-difluoromethylornithine and D,L-alpha-difluoromethylarginine. (1991) (4)
- Separation and quantitation of the polyamine biosynthesis inhibitor d,l-α-difluoromethylarginine and other guanidine-containing compounds by high-performance liquid chromatography (1990) (4)
- Activity of Novel Tryptophan Analogs against Mammalian and Trypanosomal Monoamine Oxidases (2005) (3)
- Inhibitors of trypanothione reductase as potential antitrypanosomal drugs. (1995) (3)
- Measurement of polyamine transport. Cells in suspension. (1998) (3)
- Erratum: Phenothiazine inhibitors of trypanothione reductase as potenial antitrypanosomal and antileishmanial drugs (Journal of Medicinal Chemistry (1998) 41 (150)) (1998) (3)
- Activity of Novel Tryptophan Analogs against Trypanosoma cruzi and Leishmania donovani (2009) (3)
- Glutathione Reductase in Trypanosomatids (1983) (2)
- Synthesis and enzymology of modifiedN-benzyloxycarbonyl-L-cysteinylglycyl-3,3-dimethylaminopropylamide disulphides as alternative substrates for trypanothione reductase fromTrypanosoma crud: Part 3 (2005) (2)
- Substituted Aminoacetamides as Novel Leads for Malaria Treatment (2019) (2)
- Brave new world of post-genomics! (2001) (2)
- Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase1 (2011) (2)
- Interaction of trypanocidal drugs with the metabolism and functions of trypanothione. (1990) (2)
- Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need (2018) (2)
- Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases (2021) (2)
- Properties of Trypanothione Reductase from T. brucei (2008) (1)
- Crystal Structure of Leishmania major N-myristoyltransferase with bound myristoyl-CoA (2009) (1)
- Crystal structure of the carboxy-terminal domain of HSP90 from Leishmania major, LmjF33.0312 (2009) (1)
- Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative (2010) (1)
- Bimane Cyclic Esters, Possible Stereologues of Trypanothione as Antitrypanosomal Agents. Bimanes 29. (1996) (1)
- Synthesis and Evaluation of 9,9-Dimethylxanthene Tricyclics Against Trypanothione Reductase, Trypanosoma brucei, Trypanosoma cruzi, and Leishmania donovani. (2000) (1)
- Cloning by expression of a cDNA corresponding to Leishmania donovani trypanothione reductase (1989) (1)
- A Family Infection due to Salmonella Abony. (1959) (1)
- Trypanosoma brucei The Genome of the African Trypanosome (2007) (1)
- Author response: The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis (2016) (1)
- Surmounting structural barriers to tackle endemic infectious diseases (2021) (1)
- Synthesis of polyamine-based natural products as potential antiparasitic agents (2003) (1)
- Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LmjF33.0312:M1-K213 (2009) (1)
- A comparison of two independently determined structures of trypanothione reductase from Crithidia fasciculata. (1995) (1)
- On the mathematical modelling of metabolic pathways and its use in the identification of the most suitable drug target. (2003) (1)
- Crystal structure of the N-terminal domain of Hsp90 from Leishmania major(LmjF33.0312)in complex with ADP (2012) (1)
- p-(4,6-Diamino-s-triazin-2-yl)aminophenylarsonic acid dihydrate. (1995) (1)
- Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K 213 in the presence of 17-AEP-geldanamycin (2011) (1)
- Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome (2018) (1)
- Crystallization of recombinant Crithidia fasciculata tryparedoxin. (1999) (1)
- Crystal structure of a type II tryparedoxin-dependant peroxidase from Trypanosoma brucei (2008) (0)
- Screening a protein kinase inhibitor library against Plasmodium falciparum (2017) (0)
- Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand (2014) (0)
- Studies of the reversion of chloroquine resistance by ketotifen and cyproheptadine. (1990) (0)
- University of Dundee Nongenotoxic 3-Nitroimidazo [ 1 , 2-a ] pyridines Are NTR 1 Substrates That Display Potent in Vitro Antileishmanial Activity (2019) (0)
- Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00071494) (2010) (0)
- Correction: Corrigendum: Drug resistance in eukaryotic microorganisms (2016) (0)
- CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND (2011) (0)
- Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of an inhibitor (2011) (0)
- DISCOVERY OF INHIBITORS OF TRYPANOSOMA BRUCEI TRYPANOTHIONE SYNTHETASE (2009) (0)
- [Opening Lecture] – Natural products and drug discovery for tropical diseases – successes, failures and lessons learned (2013) (0)
- Glutathionyispermidine metabolism in Escherichia coli (2005) (0)
- Oxoacyl-ACP reductase of Plasmodium falciparum (2005) (0)
- Pteridine Reductase 1 (PTR1) from Trypanosoma Brucei in complex with NADP and DDD00066641 (2009) (0)
- University of Dundee Characterisation of a putative glutamate 5kinase from Leishmania donovani (2018) (0)
- University of Dundee Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals (2018) (0)
- Cymelarsan) in aqueous solution. Properties of melarsamine hydrochloride (2013) (0)
- Drug discovery initiative at the University of Dundee: hit-to-lead development for hat and generation of chemical tools (2011) (0)
- Trypanosoma brucei trypanothione reductase with NADP and trypanothione bound (2010) (0)
- Structure Of The Bifunctional Leishmania Major Trypanothione Synthetase-Amidase (2008) (0)
- Regiocontrolled Synthesis of the Macrocyclic Polyamine Alkaloid (.+‐.)‐Lunarine, a Time‐Dependent Inhibitor of Trypanothione Reductase. (2002) (0)
- Structure of trypanothione reductase from Trypanosoma cruzi (1993) (0)
- CRYSTALLIZATION NOTE Crystallization of Recombinant Crithidia fasciculata Tryparedoxin (1999) (0)
- Erratum: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need (2017) (0)
- Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate (2006) (0)
- CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH THE INHIBITOR QUINACRINE MUSTARD (2004) (0)
- Macrocyclic Polyamine Lactam Synthesis by Diphenyl Ether Closure of 23-, 24- and 28-Membered Rings. (1999) (0)
- Para-Site-Seeing (2020) (0)
- Crystal Structure of Adenylosuccinate Lyase from Trypanosoma Brucei, Tb427tmp.160.5560 (2013) (0)
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences: 357 (1417) (2002) (0)
- Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00085762) (2010) (0)
- Cover Picture: Synthesis and Evaluation of Indatraline‐Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 / Modified 5′‐Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase (ChemMedCh (2011) (0)
- Assessment of the polyamine metabolism of filarial worms as a target for chemotherapy (1994) (0)
- Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00073357) (2010) (0)
- University of Dundee Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei (2015) (0)
- Crystal Structure of Leishmania major N-myristoyltransferase (NMT) with bound myristoyl-CoA and a pyrazole sulphonamide ligand (DDD85646) (2010) (0)
- Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity (cid:1) † (2009) (0)
- Trypanosoma brucei trypanothione reductase with bound NADP. (2010) (0)
- Crystal structure of pyridoxal kinase from Trypanosoma brucei (2012) (0)
- Parasites, Molecular Biology, Drug and Vaccine Design (1991) (0)
- University of Dundee Chemical Validation of Methionyl tRNA Synthetase ( MetRS ) as a Druggable Target in Leishmania donovani (2017) (0)
- Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative (2010) (0)
- Structure of pteridine reductase (PTR1) from Trypanosoma brucei (2005) (0)
- Cover Picture: Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis / Synthesis and Evaluation of 1‐(1‐(Benzo[b]thiophen‐2‐yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase (ChemMedChem 8/2009) (2009) (0)
- FC4 glutathionylspermidine synthethase from Crithidia fasciculata: Kinetic properties of glutathione and spermidine analogues (1994) (0)
- Bisacridines as lead anti-parasitic agents: structure activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother (2007) (0)
- Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of an the inhibitor BIIB021 (2010) (0)
- Separation and quantitation of the polyamine biosynthesis inhibitor D,L-alpha-difluoromethylarginine and other guanidine-containing compounds by high-performance liquid chromatography. (1990) (0)
- Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00065414) (2010) (0)
- Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00073359) (2010) (0)
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