Alan Fersht
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British chemist
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Chemistry
Why Is Alan Fersht Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sir Alan Roy Fersht is a British chemist at the MRC Laboratory of Molecular Biology, Cambridge, and an Emeritus Professor in the Department of Chemistry at the University of Cambridge. He was Master of Gonville and Caius College, Cambridge from 2012 to 2018. He works on protein folding, and is sometimes described as a founder of protein engineering.
Alan Fersht's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Structure and mechanism in protein science (1998) (2570)
- Enzyme structure and mechanism (1977) (2492)
- Hydrogen bonding and biological specificity analysed by protein engineering (1985) (880)
- Awakening guardian angels: drugging the p53 pathway (2009) (857)
- The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding. (1992) (850)
- Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition. (1991) (836)
- The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: evidence for a nucleation-condensation mechanism for protein folding. (1995) (700)
- Mapping the transition state and pathway of protein folding by protein engineering (1989) (652)
- Structural biology of the tumor suppressor p53. (2008) (602)
- Rescuing the function of mutant p53 (2001) (584)
- Rapid, electrostatically assisted association of proteins (1996) (538)
- Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles. (1995) (535)
- The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus) (1984) (519)
- Nucleation mechanisms in protein folding. (1997) (509)
- PRIMA-1 reactivates mutant p53 by covalent binding to the core domain. (2009) (509)
- Protein Folding and Unfolding at Atomic Resolution (2002) (460)
- The complete folding pathway of a protein from nanoseconds to microseconds (2003) (450)
- Is there a unifying mechanism for protein folding? (2003) (448)
- Optimization of rates of protein folding: the nucleation-condensation mechanism and its implications. (1995) (421)
- The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches. (2016) (418)
- The FHA domain is a modular phosphopeptide recognition motif. (1999) (414)
- Thermodynamic stability of wild-type and mutant p53 core domain. (1997) (409)
- Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy (2000) (403)
- Structure–function–rescue: the diverse nature of common p53 cancer mutants (2007) (398)
- The hydrogen bond in molecular recognition (1987) (381)
- The present view of the mechanism of protein folding (2003) (372)
- Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain (2008) (372)
- Strength and co-operativity of contributions of surface salt bridges to protein stability. (1990) (370)
- Molecular mechanism of the interaction between MDM2 and p53. (2002) (364)
- The folding of an enzyme. II. Substructure of barnase and the contribution of different interactions to protein stability. (1992) (358)
- Targeted rescue of a destabilized mutant of p53 by an in silico screened drug (2008) (351)
- Protein-protein recognition: crystal structural analysis of a barnase-barstar complex at 2.0-A resolution. (1994) (343)
- Engineered disulfide bonds as probes of the folding pathway of barnase: increasing the stability of proteins against the rate of denaturation. (1993) (329)
- Phi-value analysis and the nature of protein-folding transition states. (2004) (318)
- Transition-state structure as a unifying basis in protein-folding mechanisms: contact order, chain topology, stability, and the extended nucleus mechanism. (2000) (315)
- Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles. (1990) (315)
- Capping and α-helix stability (1989) (314)
- Energetics of complementary side-chain packing in a protein hydrophobic core. (1989) (302)
- Quantitative determination of helical propensities from trifluoroethanol titration curves. (1994) (297)
- The tumor suppressor p53: from structures to drug discovery. (2010) (290)
- Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins. (1990) (289)
- Structural basis for understanding oncogenic p53 mutations and designing rescue drugs (2006) (288)
- The crystal structure of human CD1d with and without α-galactosylceramide (2005) (281)
- Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding (1982) (280)
- Rational modification of enzyme catalysis by engineering surface charge (1987) (277)
- Characterizing transition states in protein folding: an essential step in the puzzle. (1995) (276)
- A peptide that binds and stabilizes p53 core domain: Chaperone strategy for rescue of oncogenic mutants (2002) (276)
- A Transient and Low-Populated Protein-Folding Intermediate at Atomic Resolution (2010) (275)
- Interaction of barnase with its polypeptide inhibitor barstar studied by protein engineering. (1993) (268)
- Structure and Function of Intrinsically Disordered Proteins (2009) (265)
- Aromatic-aromatic interactions and protein stability. Investigation by double-mutant cycles. (1991) (264)
- Influence of globin structure on the state of the heme. II. Allosteric transitions in methemoglobin. (1974) (246)
- Cooperative binding of tetrameric p53 to DNA. (2004) (239)
- Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability. (1998) (239)
- Protein folding and unfolding in microseconds to nanoseconds by experiment and simulation. (2000) (235)
- Solution structure of a protein denatured state and folding intermediate (2005) (232)
- Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2. (1993) (231)
- The folding of an enzyme. III. Structure of the transition state for unfolding of barnase analysed by a protein engineering procedure. (1992) (230)
- Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease. (2000) (228)
- Structure of the transition state for folding of a protein derived from experiment and simulation. (1996) (226)
- Principles of protein stability derived from protein engineering experiments (1993) (226)
- Hot-spot mutants of p53 core domain evince characteristic local structural changes. (1999) (224)
- Editing mechanisms in protein synthesis. Rejection of valine by the isoleucyl-tRNA synthetase. (1977) (222)
- Conformational equilibria in -and -chymotrypsin. The energetics and importance of the salt bridge. (1972) (222)
- Unifying features in protein-folding mechanisms (2003) (221)
- Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation. (1983) (221)
- A single-molecule characterization of p53 search on DNA (2010) (209)
- Human CD1d–glycolipid tetramers generated by in vitro oxidative refolding chromatography (2001) (206)
- Dissection of the structure and activity of the tyrosyl-tRNA synthetase by site-directed mutagenesis. (1987) (206)
- Alpha-helix stability in proteins. II. Factors that influence stability at an internal position. (1992) (204)
- Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53 (2007) (202)
- Protein folding and stability: the pathway of folding of barnase (1993) (201)
- Detection and characterization of a folding intermediate in barnase by NMR (1990) (201)
- Active site titration and aminoacyl adenylate binding stoichiometry of aminoacyl-tRNA synthetases. (1975) (200)
- Comparative binding of p53 to its promoter and DNA recognition elements. (2005) (200)
- The folding of an enzyme. IV. Structure of an intermediate in the refolding of barnase analysed by a protein engineering procedure. (1992) (199)
- Catalysis, binding and enzyme-substrate complementarity (1974) (199)
- A structural model for GroEL-polypeptide recognition. (1997) (196)
- Alpha-helix stability in proteins. I. Empirical correlations concerning substitution of side-chains at the N and C-caps and the replacement of alanine by glycine or serine at solvent-exposed surfaces. (1992) (194)
- Enzyme hyperspecificity. Rejection of threonine by the valyl-tRNA synthetase by misacylation and hydrolytic editing. (1976) (192)
- Effect of active site residues in barnase on activity and stability. (1992) (192)
- Negative activation enthalpies in the kinetics of protein folding. (1995) (191)
- Stabilization of protein structure by interaction of α-helix dipole with a charged side chain (1988) (188)
- Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and its implications for mechanisms of protein folding. (1994) (187)
- Electrostatic enhancement of diffusion-controlled protein-protein association: comparison of theory and experiment on barnase and barstar. (1998) (185)
- Characterization of the p53-rescue drug CP-31398 in vitro and in living cells (2002) (183)
- Quaternary structures of tumor suppressor p53 and a specific p53–DNA complex (2007) (182)
- Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53 (2012) (180)
- Folding of chymotrypsin inhibitor 2. 2. Influence of proline isomerization on the folding kinetics and thermodynamic characterization of the transition state of folding. (1991) (178)
- Tumor suppressor p53 slides on DNA with low friction and high stability. (2008) (177)
- The most influential journals: Impact Factor and Eigenfactor (2009) (177)
- Small molecule induced reactivation of mutant p53 in cancer cells (2013) (176)
- Prediction of electrostatic effects of engineering of protein charges (1987) (175)
- Directed evolution of new catalytic activity using the α/β-barrel scaffold (2000) (175)
- Histidine-aromatic interactions in barnase. Elevation of histidine pKa and contribution to protein stability. (1992) (175)
- Pro‐sequence‐assisted protein folding (1995) (175)
- Cooperativity in ATP hydrolysis by GroEL is increased by GroES (1991) (173)
- Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor. (2005) (173)
- Step-wise mutation of barnase to binase. A procedure for engineering increased stability of proteins and an experimental analysis of the evolution of protein stability. (1993) (172)
- Stability and function: two constraints in the evolution of barstar and other proteins. (1994) (168)
- Solution structure of p53 core domain: Structural basis for its instability (2006) (166)
- From the first protein structures to our current knowledge of protein folding: delights and scepticisms (2008) (166)
- Demonstration of the acyl-enzyme mechanism for the hydrolysis of peptides and anilides by chymotrypsin. (1973) (166)
- Single versus parallel pathways of protein folding and fractional formation of structure in the transition state. (1994) (166)
- Application of physical organic chemistry to engineered mutants of proteins: Hammond postulate behavior in the transition state of protein folding. (1993) (165)
- Protein folding from a highly disordered denatured state: The folding pathway of chymotrypsin inhibitor 2 at atomic resolution (2001) (164)
- General structural motifs of amyloid protofilaments (2006) (163)
- Structures of p53 Cancer Mutants and Mechanism of Rescue by Second-site Suppressor Mutations* (2005) (161)
- Towards a complete description of the structural and dynamic properties of the denatured state of barnase and the role of residual structure in folding. (2000) (159)
- Crystal Structure of a Superstable Mutant of Human p53 Core Domain (2004) (158)
- Effect of alanine versus glycine in α-helices on protein stability (1992) (155)
- Relationships between apparent binding energies measured in site-directed mutagenesis experiments and energetics of binding and catalysis. (1988) (154)
- Surface electrostatic interactions contribute little of stability of barnase. (1991) (152)
- Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide (2003) (150)
- Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering. (1985) (148)
- Alternative pathways for editing non-cognate amino acids by aminoacyl- tRNA synthetases (1981) (146)
- pKA values of carboxyl groups in the native and denatured states of barnase: the pKA values of the denatured state are on average 0.4 units lower than those of model compounds. (1995) (145)
- Reconstruction by site-directed mutagenesis of the transition state for the activation of tyrosine by the tyrosyl-tRNA synthetase: a mobile loop envelopes the transition state in an induced-fit mechanism. (1988) (144)
- Tailoring the pH dependence of enzyme catalysis using protein engineering (1985) (143)
- Kinetic Instability of p53 Core Domain Mutants (2003) (142)
- Kinetic basis of spontaneous mutation. Misinsertion frequencies, proofreading specificities and cost of proofreading by DNA polymerases of Escherichia coli. (1982) (142)
- The central region of HDM2 provides a second binding site for p53 (2006) (142)
- Circular dichroism studies of barnase and its mutants: characterization of the contribution of aromatic side chains. (1993) (140)
- Structural and energetic responses to cavity-creating mutations in hydrophobic cores: observation of a buried water molecule and the hydrophilic nature of such hydrophobic cavities. (1996) (138)
- Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2 (2009) (137)
- Chaperone activity and structure of monomeric polypeptide binding domains of GroEL. (1996) (135)
- Effects of Common Cancer Mutations on Stability and DNA Binding of Full-length p53 Compared with Isolated Core Domains* (2006) (135)
- Electrostatic effects on modification of charged groups in the active site cleft of subtilisin by protein engineering. (1987) (134)
- Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships. (1987) (134)
- Submillisecond events in protein folding. (1995) (133)
- A large increase in enzyme–substrate affinity by protein engineering (1984) (131)
- Structure of the hydrophobic core in the transition state for folding of chymotrypsin inhibitor 2: a critical test of the protein engineering method of analysis. (1993) (131)
- Structural evolution of p53, p63, and p73: Implication for heterotetramer formation (2009) (131)
- Catalysis of Amide Proton Exchange by the Molecular Chaperones GroEL and SecB (1996) (130)
- Two sequence motifs from HIF-1α bind to the DNA-binding site of p53 (2002) (127)
- Thermodynamics of the interaction of barnase and barstar: changes in free energy versus changes in enthalpy on mutation. (1997) (126)
- Co-operative interactions during protein folding. (1992) (125)
- Exploring the energy surface of protein folding by structure-reactivity relationships and engineered proteins: observation of Hammond behavior for the gross structure of the transition state and anti-Hammond behavior for structural elements for unfolding/folding of barnase. (1995) (123)
- Testing protein-folding simulations by experiment: B domain of protein A. (2004) (122)
- Early events in protein folding. (2003) (122)
- Kinetic characterization of the recombinant ribonuclease from Bacillus amyloliquefaciens (barnase) and investigation of key residues in catalysis by site-directed mutagenesis. (1989) (121)
- Perturbed pKA-values in the denatured states of proteins. (1995) (120)
- Refolding chromatography with immobilized mini-chaperones. (1997) (120)
- Equilibrium and rate constants for the interconversion of two conformations of -chymotrypsin. The existence of a catalytically inactive conformation at neutral p H. (1971) (120)
- Glutamine, alanine or glycine repeats inserted into the loop of a protein have minimal effects on stability and folding rates. (1997) (119)
- Stability and folding of the tumour suppressor protein p16. (1999) (119)
- The changing nature of the protein folding transition state: implications for the shape of the free-energy profile for folding. (1998) (118)
- Evidence for the double-sieve editing mechanism in protein synthesis. Steric exclusion of isoleucine by valyl-tRNA synthetases. (1979) (118)
- Fluorescence spectrum of barnase: contributions of three tryptophan residues and a histidine-related pH dependence. (1991) (117)
- Movement of the position of the transition state in protein folding. (1995) (117)
- Modulation of the Oligomerization State of p53 by Differential Binding of Proteins of the S100 Family to p53 Monomers and Tetramers♦ (2009) (117)
- Protein stability as a function of denaturant concentration: the thermal stability of barnase in the presence of urea. (1995) (116)
- Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation. (1979) (115)
- Active barnase variants with completely random hydrophobic cores. (1996) (114)
- The refolding of cis- and trans-peptidylprolyl isomers of barstar. (1993) (113)
- The folding pathway of a protein at high resolution from microseconds to seconds. (1997) (113)
- Characterization of residual structure in the thermally denatured state of barnase by simulation and experiment: description of the folding pathway. (1997) (112)
- Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA (2008) (112)
- Direct observation of ultrafast folding and denatured state dynamics in single protein molecules (2009) (111)
- Demonstration of two reaction pathways for the aminoacylation of tRNA. Application of the pulsed quenched flow technique. (1975) (111)
- Oxidative refolding chromatography: folding of the scorpion toxin Cn5 (1999) (110)
- A comparison of the pH, urea, and temperature-denatured states of barnase by heteronuclear NMR: implications for the initiation of protein folding. (1995) (110)
- Demonstration of two active sites on a monomeric aminoacyl-tRNA synthetase. Possible roles of negative cooperativity and half-of-the-sites reactivity in oligomeric enzymes. (1975) (110)
- Importance of two buried salt bridges in the stability and folding pathway of barnase. (1996) (109)
- Acetylpyridinium ion intermediate in pyridine-catalyzed hydrolysis and acyl transfer reactions of acetic anhydride. Observation, kinetics, structure-reactivity correlations, and effects of concentrated salt solutions (1970) (108)
- An evaluation of the use of hydrogen exchange at equilibrium to probe intermediates on the protein folding pathway. (1996) (107)
- Synergy between simulation and experiment in describing the energy landscape of protein folding. (1998) (107)
- Combining experiment and simulation in protein folding: closing the gap for small model systems. (2008) (106)
- Histidine residues at the N- and C-termini of alpha-helices: perturbed pKas and protein stability. (1992) (106)
- Regulation of DNA binding of p53 by its C-terminal domain. (2004) (105)
- Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. (2010) (105)
- Mechanism of folding and assembly of a small tetrameric protein domain from tumor suppressor p53 (1999) (104)
- Use of binding energy in catalysis analyzed by mutagenesis of the tyrosyl-tRNA synthetase. (1986) (103)
- CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90 (2002) (101)
- Folding of subtilisin BPN': characterization of a folding intermediate. (1993) (101)
- Leaving group specificity in the chymotrypsin-catalyzed hydrolysis of peptides. A stereochemical interpretation. (1973) (101)
- Core domain interactions in full-length p53 in solution (2006) (100)
- 14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers (2008) (99)
- Folding of subtilisin BPN': role of the pro-sequence. (1993) (99)
- Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53 (2010) (99)
- The charge relay system in chymotrypsin and chymotrypsinogen. (1973) (97)
- Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro. (2007) (97)
- Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer (2009) (96)
- Experimental assignment of the structure of the transition state for the association of barnase and barstar. (2001) (96)
- Cold denaturation of barstar: 1H, 15N and 13C NMR assignment and characterisation of residual structure. (1996) (96)
- Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation. (2004) (96)
- Refolding of barnase in the presence of GroE. (1993) (95)
- The folding of an enzyme. VI. The folding pathway of barnase: comparison with theoretical models. (1992) (95)
- Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition (2012) (95)
- Structural biology of the tumor suppressor p53 and cancer-associated mutants. (2007) (95)
- Φ-Analysis at the Experimental Limits: Mechanism of β-Hairpin Formation (2006) (94)
- Members of the S100 family bind p53 in two distinct ways (2008) (94)
- Binding of Natively Unfolded HIF-1α ODD Domain to p53 (2005) (94)
- Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53 (2009) (94)
- The crystal structure of human CD1d with and without alpha-galactosylceramide. (2005) (93)
- Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family. (2005) (93)
- Folding of circular and permuted chymotrypsin inhibitor 2: retention of the folding nucleus. (1998) (92)
- Determination of the three-dimensional solution structure of barnase using nuclear magnetic resonance spectroscopy (1991) (92)
- Conformational states bound by the molecular chaperones GroEL and secB: a hidden unfolding (annealing) activity. (1996) (92)
- The folding of an enzyme. V. H/2H exchange-nuclear magnetic resonance studies on the folding pathway of barnase: complementarity to and agreement with protein engineering studies. (1992) (92)
- Crystal structural analysis of mutations in the hydrophobic cores of barnase. (1994) (92)
- Ultrafast folding of WW domains without structured aromatic clusters in the denatured state (2001) (91)
- Modulation of binding of DNA to the C-terminal domain of p53 by acetylation. (2005) (91)
- The Crystal Structure of Human CD1b with a Bound Bacterial Glycolipid12 (2003) (91)
- Mechanism of aminoacylation of tRNA. Proof of the aminoacyl adenylate pathway for the isoleucyl- and tyrosyl-tRNA synthetases from Escherichia coli K12. (1976) (89)
- Distinguishing between cooperative and unimodal downhill protein folding (2007) (87)
- Probing the principles of amino acid selection using the alanyl-tRNA synthetase from Escherichia coli. (1981) (87)
- Intrinsically disordered p53 and its complexes populate compact conformations in the gas phase. (2013) (87)
- Three-dimensional solution structure and 13C assignments of barstar using nuclear magnetic resonance spectroscopy. (1994) (86)
- Quantitative analysis of structure–activity relationships in engineered proteins by linear free-energy relationships (1986) (86)
- Analysis of Enzyme Structure and Activity by Protein Engineering (1984) (86)
- Sequence-dependent sliding kinetics of p53 (2012) (85)
- Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration (2011) (85)
- Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53 (2008) (85)
- Acyl-transfer reactions of amides and esters with alcohols and thiols. A reference system for the serine and cysteine proteinases. Concerning the N protonation of amides and amide-imidate equilibria. (1971) (84)
- Design of a molecular support for cryo-EM structure determination (2016) (84)
- Probing the limits of protein-amino acid side chain recognition with the aminoacyl-tRNA synthetases. Discrimination against phenylalanine by tyrosyl-tRNA synthetases. (1980) (83)
- Titration properties and thermodynamics of the transition state for folding: comparison of two-state and multi-state folding pathways. (1996) (83)
- Tyrosyl-tRNA synthetase from Escherichia coli. Stoichiometry of ligand binding and half-of-the-sites reactivity in aminoacylation. (1975) (83)
- An N-terminal fragment of barnase has residual helical structure similar to that in a refolding intermediate. (1992) (83)
- Sequential unfolding of ankyrin repeats in tumor suppressor p16. (2003) (82)
- Equilibrium folding properties of the yeast prion protein determinant Ure2. (1999) (82)
- Structures of closed and open conformations of dimeric human ATM (2017) (82)
- Conformational entropy of alanine versus glycine in protein denatured states (2007) (81)
- Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer (2011) (80)
- The denatured state of Engrailed Homeodomain under denaturing and native conditions. (2003) (80)
- Recognition of DNA by p53 core domain and location of intermolecular contacts of cooperative binding. (2002) (79)
- Ligand binding and enzymic catalysis coupled through subunits in tyrosyl-tRNA synthetase. (1975) (79)
- Chemical physics of protein folding (1998) (78)
- Protein engineering in analysis of protein folding pathways and stability. (1991) (78)
- Toward a mechanism for GroEL.GroES chaperone activity: an ATPase-gated and -pulsed folding and annealing cage. (1996) (78)
- The helix–turn–helix motif as an ultrafast independently folding domain: The pathway of folding of Engrailed homeodomain (2007) (77)
- Rapid amyloid fiber formation from the fast-folding WW domain FBP28 (2003) (77)
- 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells (2016) (77)
- Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents. (2006) (77)
- Nature and consequences of GroEL-protein interactions. (1995) (76)
- Loss of a metal-binding site in gelsolin leads to familial amyloidosis–Finnish type (2002) (75)
- Hydrogen exchange in chymotrypsin inhibitor 2 probed by denaturants and temperature. (1997) (75)
- Upper limit of the time scale for diffusion and chain collapse in chymotrypsin inhibitor 2 (1999) (74)
- Subsite binding in an RNase: structure of a barnase-tetranucleotide complex at 1.76-A resolution. (1994) (74)
- The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells (2009) (74)
- An editing mechanism for the methionyl-tRNA synthetase in the selection of amino acids in protein synthesis. (1979) (74)
- On the simulation of protein folding by short time scale molecular dynamics and distributed computing (2002) (73)
- Mimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity (2003) (73)
- Dissection of an enzyme by protein engineering. The N and C-terminal fragments of barnase form a native-like complex with restored enzymic activity. (1992) (72)
- Mechanism of chymotrypsin. Structure, reactivity, and nonproductive binding relationships. (1973) (72)
- Design of highly stable functional GroEL minichaperones (1999) (72)
- Extrapolation to water of kinetic and equilibrium data for the unfolding of barnase in urea solutions. (1994) (72)
- The kinetic pathway of folding of barnase. (2003) (71)
- The hydrolysis of aspirin. Intramolecular general base catalysis of ester hydrolysis. (1967) (71)
- Direct observation of better hydration at the N terminus of an alpha-helix with glycine rather than alanine as the N-cap residue. (1994) (71)
- Cysteinyl-tRNA synthetase from Escherichia coli does not need an editing mechanism to reject serine and alanine. High binding energy of small groups in specific molecular interactions. (1979) (71)
- Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA (2010) (71)
- Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation". (2004) (71)
- Exploring the folding funnel of a polypeptide chain by biophysical studies on protein fragments. (1999) (71)
- Electrocatalytic monitoring of metal binding and mutation-induced conformational changes in p53 at picomole level. (2011) (70)
- Mutually compensatory mutations during evolution of the tetramerization domain of tumor suppressor p53 lead to impaired hetero-oligomerization. (1999) (70)
- One-state downhill versus conventional protein folding. (2004) (70)
- Search for nucleation sites in smaller fragments of chymotrypsin inhibitor 2. (1995) (69)
- Binding energy and catalysis: a lesson from protein engineering of the tyrosyl-tRNA synthetase (1986) (69)
- A kinetically significant intermediate in the folding of barnase. (2000) (69)
- DNA polymerase accuracy and spontaneous mutation rates: frequencies of purine.purine, purine.pyrimidine, and pyrimidine.pyrimidine mismatches during DNA replication. (1981) (69)
- Probing histidine-substrate interactions in tyrosyl-tRNA synthetase using asparagine and glutamine replacements. (1985) (69)
- Relationship between equilibrium amide proton exchange behavior and the folding pathway of barnase. (1995) (69)
- Initiation sites of protein folding by NMR analysis. (1996) (68)
- Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53. (2009) (68)
- Hydrogen exchange in chymotrypsin inhibitor 2 probed by mutagenesis. (1997) (67)
- Formation of short-lived protein aggregates directly from the coil in two-state folding. (1999) (67)
- Recombinant chymotrypsin inhibitor 2: expression, kinetic analysis of inhibition with alpha-chymotrypsin and wild-type and mutant subtilisin BPN', and protein engineering to investigate inhibitory specificity and mechanism. (1990) (66)
- Folding of a nascent polypeptide chain in vitro: cooperative formation of structure in a protein module. (1995) (66)
- Long-range surface charge-charge interactions in proteins. Comparison of experimental results with calculations from a theoretical method. (1993) (66)
- Hydrogen bonding in enzymatic catalysis analysed by protein engineering (1985) (66)
- Thermodynamic study of the acid denaturation of barnase and its dependence on ionic strength: evidence for residual electrostatic interactions in the acid/thermally denatured state. (1994) (65)
- The solution structure of oxidized Escherichia coli cytochrome b562. (1999) (65)
- Conformational pathway of the polypeptide chain of chymotrypsin inhibitor-2 growing from its N terminus in vitro. Parallels with the protein folding pathway. (1995) (65)
- Side-chain determinants of beta-sheet stability. (1995) (65)
- Structural response to mutation at a protein-protein interface. (1998) (64)
- Deletion mutagenesis using an ‘M13 splint’: the N‐terminal structural domain of tyrosyl‐tRNA synthetase (B. stearothermophilus) catalyses the formation of tyrosyl adenylate. (1983) (64)
- Contribution of long-range electrostatic interactions to the stabilization of the catalytic transition state of the serine protease subtilisin BPN'. (1993) (64)
- Direct observation of complexes formed between recA protein and a fluorescent single-stranded deoxyribonucleic acid derivative. (1982) (64)
- The binding of bis-ANS to the isolated GroEL apical domain fragment induces the formation of a folding intermediate with increased hydrophobic surface not observed in tetradecameric GroEL. (2001) (63)
- Protein folding and binding: moving into unchartered territory. (2009) (63)
- Folding of barnase in parts. (1994) (63)
- Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes. (2004) (63)
- Contribution of 3′ → 5′ exonuclease activity of DNA polymerase III holoenzyme from Escherichia coli to specificity* (1983) (62)
- Binding of Rad51 and Other Peptide Sequences to a Promiscuous, Highly Electrostatic Binding Site in p53* (2005) (62)
- Capping and alpha-helix stability. (1989) (62)
- Human full‐length Securin is a natively unfolded protein (2005) (61)
- The folding of GroEL-bound barnase as a model for chaperonin-mediated protein folding. (1995) (61)
- In vivo activities of GroEL minichaperones. (1998) (61)
- Simulation and experiment conspire to reveal cryptic intermediates and a slide from the nucleation-condensation to framework mechanism of folding. (2005) (61)
- Comparative Biophysical Characterization of p53 with the Pro-apoptotic BAK and the Anti-apoptotic BCL-xL* (2007) (61)
- Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding (2010) (60)
- Direct observation of barrier-limited folding of BBL by single-molecule fluorescence resonance energy transfer (2009) (60)
- Multisite aggregation of p53 and implications for drug rescue (2017) (60)
- Rapid intramolecular coupling of active sites in the pyruvate dehydrogenase complex of Escherichia coli: mechanism for rate enhancement in a multimeric structure. (1978) (60)
- The Crystal Structure of Human CD1b with a Bound Bacterial Glycolipid (2004) (59)
- recA protein from Escherichia coli. a very rapid and simple purification procedure: binding of adenosine 5'-triphosphate and adenosine 5'-diphosphate by the homogeneous protein. (1982) (59)
- The structure of the major transition state for folding of an FF domain from experiment and simulation. (2005) (59)
- Contribution of buried hydrogen bonds to protein stability. The crystal structures of two barnase mutants. (1993) (58)
- Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values. (2005) (58)
- Reaction pathway and rate-determining step in the aminoacylation of tRNAArg catalyzed by the arginyl-tRNA synthetase from yeast. (1978) (58)
- Combined Molecular Dynamics and Φ-Value Analysis of Structure−Reactivity Relationships in the Transition State and Unfolding Pathway of Barnase: Structural Basis of Hammond and Anti-Hammond Effects (1998) (58)
- Establishing the misacylation/deacylation of the tRNA pathway for the editing mechanism of prokaryotic and eukaryotic valyl-tRNA synthetases. (1979) (58)
- Mechanism of the -chymotrypsin-catalyzed hydrolysis of amides. pH dependence of k c and K m . Kinetic detection of an intermediate. (1971) (58)
- The folding pathway of an FF domain: characterization of an on-pathway intermediate state under folding conditions by (15)N, (13)C(alpha) and (13)C-methyl relaxation dispersion and (1)H/(2)H-exchange NMR spectroscopy. (2007) (57)
- Phi-analysis of the folding of the B domain of protein A using multiple optical probes. (2006) (56)
- Importance of electrostatic interactions in the rapid binding of polypeptides to GroEL. (1997) (56)
- Review Lecture Enzymic editing mechanisms and the genetic code (1981) (56)
- Analysis of the role of the KMSKS loop in the catalytic mechanism of the tyrosyl-tRNA synthetase using multimutant cycles. (1995) (56)
- Hydrogen exchange at equilibrium: a short cut for analysing protein-folding pathways? (1997) (55)
- Relationship of Leffler (Brønsted) α values and protein folding Φ values to position of transition-state structures on reaction coordinates (2004) (55)
- Nonsequential unfolding of the alpha/beta barrel protein indole-3-glycerol-phosphate synthase. (1997) (55)
- Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms (2009) (55)
- Toward solving the folding pathway of barnase: the complete backbone 13C, 15N, and 1H NMR assignments of its pH-denatured state. (1994) (54)
- Mapping transition states of protein unfolding by protein engineering of ligand-binding sites. (1991) (54)
- pH dependence of chymotrypsin catalysis. Appendix: substrate binding to dimeric alpha-chymotrypsin studied by x-ray diffraction and the equilibrium method. (1974) (54)
- Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2 (2010) (54)
- A search for single substitutions that eliminate enzymatic function in a bacterial ribonuclease. (1998) (52)
- Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding (2015) (52)
- Basis of biological specificity (1984) (51)
- Molecular basis of S100 proteins interacting with the p53 homologs p63 and p73 (2010) (51)
- Natural variation of tyrosyl-tRNA synthetase and comparison with engineered mutants. (1986) (51)
- Ultraslow oligomerization equilibria of p53 and its implications (2009) (51)
- The effects of disulfide bonds on the denatured state of barnase (2000) (50)
- First-order rate-determining aggregation mechanism of p53 and its implications (2012) (50)
- Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2 (2012) (50)
- Long-Range Modulation of Chain Motions within the Intrinsically Disordered Transactivation Domain of Tumor Suppressor p53 (2011) (50)
- NMR analysis of the binding of a rhodanese peptide to a minichaperone in solution. (1999) (49)
- MDMX contains an autoinhibitory sequence element (2013) (49)
- Generation of a family of protein fragments for structure-folding studies. 1. Folding complementation of two fragments of chymotrypsin inhibitor-2 formed by cleavage at its unique methionine residue. (1994) (49)
- Structural Biology: Analysis of 'downhill' protein folding (2007) (48)
- Local breathing and global unfolding in hydrogen exchange of barnase and its relationship to protein folding pathways. (1993) (48)
- Folding intermediates of wild-type and mutants of barnase. I. Use of phi-value analysis and m-values to probe the cooperative nature of the folding pre-equilibrium. (1998) (48)
- Harnessing Fluorine–Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs (2016) (48)
- A calorimetric study of the thermal stability of barnase and its interaction with 3'GMP. (1994) (47)
- Equilibria and kinetics of folding of gelsolin domain 2 and mutants involved in familial amyloidosis-Finnish type. (1999) (47)
- Disulfide mutants of barnase. I: Changes in stability and structure assessed by biophysical methods and X-ray crystallography. (1995) (47)
- Editing mechanisms in aminoacylation of tRNA: ATP consumption and the binding of aminoacyl-tRNA by elongation factor Tu. (1977) (47)
- Time-resolved fluorescence resonance energy transfer study shows a compact denatured state of the B domain of protein A. (2009) (47)
- Simulation and experiment at high temperatures: ultrafast folding of a thermophilic protein by nucleation-condensation. (2005) (46)
- Reactions of nucleophilic reagents with acylating agents of extreme reactivity and unreactivity. Correlation of .beta. values for attacking and leaving group variation (1970) (46)
- The role of Glu73 of barnase in catalysis and the binding of barstar. (1997) (46)
- Engineering a novel specificity in subtilisin BPN'. (1993) (46)
- Mutational and kinetic analysis of a mobile loop in tyrosyl-tRNA synthetase. (1993) (45)
- Reversible dissociation of dimeric tyrosyl-tRNA synthetase by mutagenesis at the subunit interface. (1985) (45)
- Directed evolution of new catalytic activity using the alpha/beta-barrel scaffold. (2000) (45)
- Effects of Oncogenic Mutations and DNA Response Elements on the Binding of p53 to p53-binding Protein 2 (53BP2)* (2006) (45)
- Barnase has subsites that give rise to large rate enhancements. (1992) (45)
- Domain–domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy (2012) (44)
- Formation of electrostatic interactions on the protein-folding pathway. (1996) (44)
- Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007. (2018) (44)
- Time-resolved small-angle X-ray scattering study of the folding dynamics of barnase. (2011) (44)
- Tyrosyl-tRNA synthetase acts as an asymmetric dimer in charging tRNA. A rationale for half-of-the-sites activity. (1988) (44)
- Variants of subtilisin BPN' with altered specificity profiles. (1994) (44)
- GroEL recognises sequential and non-sequential linear structural motifs compatible with extended beta-strands and alpha-helices. (1999) (44)
- Fidelity of replication of bacteriophage phi X174 DNA in vitro and in vivo. (1983) (44)
- Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines (2018) (43)
- Internal thermodynamics of position 51 mutants and natural variants of tyrosyl-tRNA synthetase. (1986) (43)
- Protein engineering and the study of structure--function relationships in receptors. (1990) (43)
- Asymmetry of tyrosyl-tRNA synthetase in solution. (1988) (43)
- Effect of alanine versus glycine in alpha-helices on protein stability. (1992) (43)
- Binding of natively unfolded HIF-1alpha ODD domain to p53. (2005) (43)
- Sieves in Sequence (1998) (43)
- Protein fragments as models for events in protein folding pathways: protein engineering analysis of the association of two complementary fragments of the barley chymotrypsin inhibitor 2 (CI-2). (1995) (42)
- Determination of the excited-state lifetimes of the tryptophan residues in barnase, via multifrequency phase fluorometry of tryptophan mutants. (1992) (42)
- High Temperature Unfolding Simulations of the TRPZ1 Peptide (2008) (42)
- Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53 (2015) (42)
- Folding of the yeast prion protein Ure2: kinetic evidence for folding and unfolding intermediates. (2002) (42)
- Thermodynamics of transient conformations in the folding pathway of barnase: reorganization of the folding intermediate at low pH. (1996) (42)
- Thermodynamic stability and folding of GroEL minichaperones. (1998) (41)
- Detection of an intermediate in the folding of the (beta alpha)8-barrel N-(5'-phosphoribosyl)anthranilate isomerase from Escherichia coli. (1994) (41)
- Minimal and optimal mechanisms for GroE-mediated protein folding. (1998) (41)
- Ligand binding stoichiometries, subunit structure, and slow transitions in aminoacyl-tRNA synthetases. (1977) (40)
- Rationally designing the accumulation of a folding intermediate of barnase by protein engineering. (1993) (40)
- Analysis of protein-protein interactions by mutagenesis: direct versus indirect effects. (1999) (40)
- Backbone dynamics of chymotrypsin inhibitor 2: effect of breaking the active site bond and its implications for the mechanism of inhibition of serine proteases. (1995) (40)
- Refolding of barnase mutants and pro‐barnase in the presence and absence of GroEL. (1993) (40)
- Complementation of peptide fragments of the single domain protein chymotrypsin inhibitor 2. (1997) (40)
- Kinetic significance of GroEL14.(GroES7)2 complexes in molecular chaperone activity. (1996) (39)
- Circular dichroism of denatured barstar suggests residual structure,. (1997) (39)
- A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C (2019) (39)
- Molecular basis of the interactions between the p73 N terminus and p300: Effects on transactivation and modulation by phosphorylation (2009) (39)
- Free energies of hydrolysis of amides and peptides in aqueous solution at 25 degrees. (1971) (39)
- Mapping the structures of transition states and intermediates in folding: delineation of pathways at high resolution. (1995) (39)
- Conversion of allosteric inhibition to activation in phosphofructokinase by protein engineering (1987) (38)
- The role of the turn in β‐hairpin formation during WW domain folding (2007) (38)
- A calorimetric study of the thermal stability of barstar and its interaction with barnase. (1995) (38)
- Interaction between the Transactivation Domain of p53 and PC4 Exemplifies Acidic Activation Domains as Single-stranded DNA Mimics (2009) (38)
- Modification of the amino acid specificity of tyrosyl‐tRNA synthetase by protein engineering (1993) (37)
- Adaptive evolution of p53 thermodynamic stability. (2009) (37)
- Generation of a family of protein fragments for structure-folding studies. 2. Kinetics of association of the two chymotrypsin inhibitor-2 fragments. (1994) (37)
- Structural factors contributing to the hydrophobic effect: the partly exposed hydrophobic minicore in chymotrypsin inhibitor 2. (1995) (37)
- Nonnative interactions in the FF domain folding pathway from an atomic resolution structure of a sparsely populated intermediate: an NMR relaxation dispersion study. (2011) (37)
- Anomalous pH dependence of kcat-KM in enzyme reactions. Rate constants for the association of chymotrypsin with substrates. (1973) (36)
- Identification of substrate binding site of GroEL minichaperone in solution. (1999) (36)
- From minichaperone to GroEL 3: properties of an active single-ring mutant of GroEL. (2000) (36)
- COSMIC analysis of the major α-helix of barnase during folding (1991) (36)
- S100 proteins interact with the N‐terminal domain of MDM2 (2010) (35)
- Stabilization of protein structure by interaction of alpha-helix dipole with a charged side chain. (1988) (35)
- A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase. (2002) (35)
- Mutation of lysine 233 to alanine introduces positive cooperativity into tyrosyl-tRNA synthetase. (1993) (35)
- Stabilization of GroEL minichaperones by core and surface mutations. (2000) (35)
- The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53 (2018) (35)
- Towards the complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two complementary fragments of cleaved chymotrypsin inhibitor 2. Direct evidence for a nucleation-condensation mechanism. (1996) (35)
- Movement of the intermediate and rate determining transition state of barnase on the energy landscape with changing temperature. (1998) (34)
- Searching for multiple folding pathways of a nearly symmetrical protein: temperature dependent phi-value analysis of the B domain of protein A. (2007) (34)
- The structure of the transition state for the association of two fragments of the barley chymotrypsin inhibitor 2 to generate native-like protein: implications for mechanisms of protein folding. (1994) (34)
- NMR 15N relaxation and structural studies reveal slow conformational exchange in barstar C40/82A. (1997) (34)
- Phi-analysis at the experimental limits: mechanism of beta-hairpin formation. (2006) (34)
- Crystal Structures of Engrailed Homeodomain Mutants (2003) (34)
- Identification of the barstar binding site of barnase by NMR spectroscopy and hydrogen‐deuterium exchange (1993) (34)
- Structure and mechanism in intramolecular catalysis. The hydrolysis of substituted aspirins. (1967) (34)
- Acquisition of native-like interactions in C-terminal fragments of barnase. (1999) (33)
- Reaction of modified and unmodified tRNA(Tyr) substrates with tyrosyl-tRNA synthetase (Bacillus stearothermophilus). (1993) (33)
- Investigation of transition-state stabilization by residues histidine-45 and threonine-40 in the tyrosyl-tRNA synthetase. (1987) (33)
- Sequential assignment of the 1H nuclear magnetic resonance spectrum of barnase. (1990) (33)
- Stability of p53 Homologs (2012) (33)
- Folding intermediates of wild-type and mutants of barnase. II. Correlation of changes in equilibrium amide exchange kinetics with the population of the folding intermediate. (1998) (33)
- Kinetics of chain motions within a protein-folding intermediate (2010) (32)
- Thermodynamics of denaturation of mutants of barnase with disulfide crosslinks. (1997) (32)
- Fine structure-activity analysis of mutations at position 51 of tyrosyl-tRNA synthetase. (1985) (32)
- Contribution of residues in the reactive site loop of chymotrypsin inhibitor 2 to protein stability and activity. (1994) (32)
- Strain in the folding nucleus of chymotrypsin inhibitor 2. (1997) (31)
- Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus (2007) (31)
- Use of binding energy in catalysis: optimization of rate in a multistep reaction. (1993) (31)
- Folding and binding: implementing the game plan (2007) (31)
- Downhill versus barrier-limited folding of BBL 1: energetic and structural perturbation effects upon protonation of a histidine of unusually low pKa. (2009) (31)
- Mutation of asparagine 111 of rubisco from Rhodospirillum rubrum alters the carboxylase/oxygenase specificity. (1992) (31)
- Involvement of threonine 234 in catalysis of tyrosyl adenylate formation by tyrosyl-tRNA synthetase. (1993) (31)
- Following co-operative formation of secondary and tertiary structure in a single protein module. (1997) (30)
- Folding of barstar C40A/C82A/P27A and catalysis of the peptidyl‐prolyl cis/trans isomerization by human cytosolic cyclophilin (Cyp18) (1999) (30)
- New approach to the study of transient protein conformations: the formation of a semiburied salt link in the folding pathway of barnase. (1996) (30)
- Solution structure of the U11-48K CHHC zinc-finger domain that specifically binds the 5' splice site of U12-type introns. (2009) (30)
- Dissection of the effector-binding site and complementation studies of Escherichia coli phosphofructokinase using site-directed mutagenesis. (1989) (30)
- The valyl-tRNA synthetase from Bacillus stearothermophilus has considerable sequence homology with the isoleucyl-tRNA synthetase from Escherichia coli. (1987) (29)
- Structure of the C-terminal sterile α-motif (SAM) domain of human p73α (2001) (29)
- New Look and New Outlook (2002) (29)
- Kinetics of base misinsertion by DNA polymerase I of Escherichia coli. (1983) (29)
- Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold. (2007) (28)
- Analyse von Struktur‐Aktivitäts‐Beziehungen bei Enzymen durch Protein‐Engineering (1984) (28)
- Kinetic and thermodynamic properties of wild-type and engineered mutants of tyrosyl-tRNA synthetase analyzed by pyrophosphate-exchange kinetics. (1991) (28)
- Mechanism of initiation of aggregation of p53 revealed by Φ-value analysis (2015) (28)
- α-Helix stability in proteins (1992) (28)
- Fluorescence properties of a tryptophan residue in an aromatic core of the protein subunit of ribonuclease P from Escherichia coli. (1997) (27)
- Characterization of phosphate binding in the active site of barnase by site-directed mutagenesis and NMR. (1991) (27)
- The folding mechanism of BBL: Plasticity of transition-state structure observed within an ultrafast folding protein family. (2009) (27)
- Effects of heme on the structure of the denatured state and folding kinetics of cytochrome b562. (2005) (27)
- Mechanism of aminoacylation of transfer RNA. A pre-steady-state analysis of the reaction pathway catalyzed by the methionyl-tRNA synthetase of Bacillus stearothermophilus. (1978) (27)
- Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core (2009) (27)
- The A-state of barnase. (1994) (26)
- Accuracy of DNA polymerase‐alpha in copying natural DNA. (1983) (26)
- Downhill versus barrier-limited folding of BBL 2: mechanistic insights from kinetics of folding monitored by independent tryptophan probes. (2009) (26)
- Mutational analysis of the N-capping box of the α-helix of chymotrypsin inhibitor 2 (1994) (26)
- Conformational equilibria and the salt bridge in chymotrypsin. (1972) (25)
- PFD: a database for the investigation of protein folding kinetics and stability (2004) (25)
- Enzymic editing mechanisms in protein synthesis and DNA replication (1980) (25)
- Pathway of protein folding. (1992) (25)
- The aminoacyladenylate mechanism in the aminoacylation reaction of yeast phenylalanyl-tRNA synthetase. (1978) (25)
- The Development of a CDK2-Docking Site Peptide that Inhibits p53 and Sensitizes Cells to Death (2004) (25)
- Disulfide mutants of barnase. II: Changes in structure and local stability identified by hydrogen exchange. (1995) (25)
- Refolding the engrailed homeodomain: structural basis for the accumulation of a folding intermediate. (2010) (24)
- Relationship of Leffler (Bronsted) alpha values and protein folding Phi values to position of transition-state structures on reaction coordinates. (2004) (24)
- Structural studies on peptides corresponding to mutants of the major alpha-helix of barnase. (1994) (24)
- Subunit interactions in the methionyl-tRNA synthetase of Bacillus stearothermophilus. (1976) (24)
- Elucidating the mechanism of familial amyloidosis- Finnish type: NMR studies of human gelsolin domain 2. (2000) (24)
- The transition state for folding of a peripheral subunit-binding domain contains robust and ionic-strength dependent characteristics. (2006) (24)
- Transdisciplinary EU science institute needs funds urgently (2010) (24)
- Phi value versus psi analysis. (2004) (23)
- Folding of barnase in the presence of the molecular chaperone SecB. (1997) (23)
- Analysis of the mechanism of assembly of cleaved barnase from two peptide fragments and its relevance to the folding pathway of uncleaved barnase. (1995) (23)
- recA Filaments in solution (1983) (23)
- Site-directed mutagenesis in the effector site of Escherichia coli phosphofructokinase. (1987) (23)
- Free energy of hydrolysis of tyrosyl adenylate and its binding to wild-type and engineered mutant tyrosyl-tRNA synthetases. (1986) (22)
- Determination of the three-dimensional solution structure of barnase using nuclear magnetic resonance spectroscopy. (1991) (22)
- Can a simple function for the dielectric response model electrostatic effects in globular proteins? (1989) (22)
- The rate of isomerisation of peptidyl-proline bonds as a probe for interactions in the physiological denatured state of chymotrypsin inhibitor 2. (1997) (22)
- Malleability of folding intermediates in the homeodomain superfamily (2011) (22)
- Effects of engineering complementary charged residues into the hydrophobic subunit interface of tyrosyl-tRNA synthetase. Appendix: Kinetic analysis of dimeric enzymes that reversibly dissociate into inactive subunits. (1987) (22)
- Proteins of the S 100 family regulate the oligomerization of p 53 tumor suppressor (2005) (22)
- The Structure of Love. (1991) (21)
- Contribution of a proline residue and a salt bridge to the stability of a type I reverse turn in chymotrypsin inhibitor-2. (1994) (21)
- An NMR study on the β-hairpin region of barnase (1996) (21)
- An irregular beta-bulge common to a group of bacterial RNases is an important determinant of stability and function in barnase. (1999) (21)
- Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm (2020) (21)
- Conversion of two-state to multi-state folding kinetics on fusion of two protein foldons. (2000) (21)
- Acetylpyridinium ion intermediate in pyridine-catalyzed acyl transfer (1969) (21)
- Site-directed mutagenesis reveals transition-state stabilization as a general catalytic mechanism for aminoacyl-tRNA synthetases. (1987) (20)
- The charging of tRNA (1986) (20)
- Structure and activity of the tyrosy1-tRNA synthetase: the hydrogen bond in catalysis and specificity (1986) (20)
- Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere (2015) (20)
- Editing Mechanisms in the Aminoacylation of tRNA (1979) (20)
- Characterization of the native and fibrillar conformation of the human Nα‐acetyltransferase ARD1 (2006) (20)
- Real‐time NMR studies on folding of mutants of barnase and chymotrypsin inhibitor 2 (1998) (20)
- Structure-activity relationships in engineered proteins: characterization of disruptive deletions in the alpha-ammonium group binding site of tyrosyl-tRNA synthetase. (1987) (20)
- Intramolecular nucleophilic catalysis of ester hydrolysis by the ionized carboxyl group. The hydrolysis of 3,5-dinitroaspirin anion. (1968) (19)
- Pathway and stability of protein folding. (1991) (19)
- SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma (2019) (19)
- Fluorescence resonance energy transfer analysis of the folding pathway of Engrailed Homeodomain. (2008) (19)
- From minichaperone to GroEL 1: information on GroEL-polypeptide interactions from crystal packing of minichaperones. (2000) (19)
- Investigation of binding between recA protein and single-stranded polynucleotides with the aid of a fluorescent deoxyribonucleic acid derivative. (1983) (19)
- Enzymic editing mechanisms and the genetic code. (1981) (18)
- Protein Folding Transition States: Elicitation of Hammond Effects by 2,2,2‐Trifluoroethanol (2000) (18)
- Conservation of transition state structure in fast folding peripheral subunit-binding domains. (2008) (18)
- Phosphotriesterase variants with high methylphosphonatase activity and strong negative trade-off against phosphotriesters. (2011) (18)
- Real‐time nmr studies on a transient folding intermediate of barstar (1999) (18)
- From minichaperone to GroEL 2: importance of avidity of the multisite ring structure. (2000) (18)
- Protein engineering of homodimeric tyrosyl-tRNA synthetase to produce active heterodimers. (1986) (18)
- Designing a metal-binding site in the scaffold of Escherichia coli KDO8PS. (2004) (17)
- Linear free energy relationships in enzyme binding interactions studied by protein engineering. (1991) (17)
- Structure and dynamics of barnase complexed with 3'-GMP studied by NMR spectroscopy. (1993) (17)
- Carboxyl pK(a) values and acid denaturation of BBL. (2010) (17)
- Pathway and Stability of Protein Folding (1994) (17)
- Interdomain interactions within the gene 3 protein of filamentous phage (1999) (17)
- AlphaFold - A personal perspective on the impact of Machine Learning. (2021) (16)
- Highest paraoxonase turnover rate found in a bacterial phosphotriesterase variant. (2011) (16)
- A reply to Englander and Woodward (1998) (16)
- Assignment of the backbone 1H and 15N NMR resonances and secondary structure characterization of barstar (1993) (16)
- An in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein. (2016) (15)
- Correlations between kinetic and X-ray analyses of engineered enzymes: crystal structures of mutants Cys----Gly-35 and Tyr----Phe-34 of tyrosyl-tRNA synthetase. (1991) (15)
- Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p 53 (2009) (15)
- Downhill versus barrier-limited folding of BBL 3. Heterogeneity of the native state of the BBL peripheral subunit binding domain and its implications for folding mechanisms. (2009) (15)
- Structure of human MDM4 N-terminal domain bound to a single-domain antibody. (2008) (14)
- Structure of the C-terminal sterile alpha-motif (SAM) domain of human p73 alpha. (2001) (14)
- Protein stability: experimental data from protein engineering (1993) (14)
- Stability and folding of the protein complexes of barnase. (2000) (14)
- Linear free energy relationships are valid! (1987) (14)
- Helix stability in barstar peptides. (1997) (13)
- Evaluating Drosophila p53 as a Model System for Studying Cancer Mutations* (2012) (13)
- Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 Nobel Laureates in Chemistry (2013) (12)
- Intramolecular nucleophilic catalysis in the hydrolysis of substituted aspirin acids. (1968) (12)
- Assignment of histidine resonances in the 1H NMR (500 MHz) spectrum of subtilisin BPN' using site-directed mutagenesis. (1988) (11)
- The role of the turn in beta-hairpin formation during WW domain folding. (2007) (11)
- retraction: Directed evolution of new catalytic activity using the α/β-barrel scaffold (2002) (11)
- A Sequential Assignment Procedure for Proteins that have Intermediate Line Widths in MAS NMR Spectra: Amyloid Fibrils of Human CA150.WW2 (2008) (11)
- Characterization of in vitro oxidized barstar (1995) (11)
- Series nucleophilic catalysis in the hydrolysis of 3-acetoxyphthalate. Intramolecular catalysis of ester hydrolysis by the carboxyl group once removed (1968) (10)
- Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation (2015) (10)
- Molecular cloning of the gene encoding the valyl-tRNA synthetase from Bacillus stearothermophilus. (1986) (10)
- Role of isoleucine-164 at the active site of rubisco from Rhodospirillum rubrum. (1997) (9)
- Demonstration by burst-phase analysis of a robust folding intermediate in the FF domain. (2008) (9)
- Engineering a two-helix bundle protein for folding studies (2010) (9)
- Folding of the Pit1 homeodomain near the speed limit (2010) (9)
- Biophysical characterization of elongin C from Saccharomyces cerevisiae. (2000) (8)
- Role of phenylalanine-327 in the closure of loop 6 of ribulosebisphosphate carboxylase/oxygenase from Rhodospirillum rubrum. (1993) (8)
- Contribution of 3' leads to 5' exonuclease activity of DNA polymerase III holoenzyme from Escherichia coli to specificity. (1983) (8)
- Combination of Markov State Models and Kinetic Networks for the Analysis of Molecular Dynamics Simulations of Peptide Folding (2011) (8)
- Retraction. Directed evolution of new catalytic activity using the alpha/beta-barrel scaffold. (2002) (8)
- Fidelity of DNA replication under conditions used for oligodeoxynucleotide-directed mutagenesis. (1984) (8)
- Protein folding: Think globally, (inter)act locally (1998) (8)
- Direct observation of complexes of ssb and recA proteins with a fluorescent single-stranded deoxyribonucleic acid derivative. (1983) (8)
- Measurement of barnase refolding rate constants under denaturing conditions (1994) (8)
- Metal ion dependence of phosphorothioate ATP analogues in the Bacillus stearothermophilus tyrosyl-tRNA synthetase reaction. (1990) (8)
- In support of the BMRB (2012) (7)
- Mutational analysis of the N-capping box of the alpha-helix of chymotrypsin inhibitor 2. (1994) (7)
- Wild Type p53 Conformation, Structural Consequences of p53 Mutations and Mechanisms of Mutant p53 Rescue (2007) (7)
- Insertion in barnase of a loop sequence from ribonuclease T1. Investigating sequence and structure alignments by protein engineering. (1994) (6)
- Interaction of the p 53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p 53 Tetramer (2011) (6)
- The catalytic activity of the inactive conformation of δ‐chymotrypsin (1973) (6)
- Folding pathway enigma (1990) (6)
- Protein engineering. (1992) (6)
- Protection of an unstable reaction intermediate examined with linear free energy relationships in tyrosyl-tRNA synthetase. (1989) (6)
- Barnase: Fluorescence Analysis of A Three Tryptophan Protein (2002) (5)
- Protein engineering. (1986) (5)
- Don’t waste good methods on bad buffers and ambiguous data (2013) (5)
- Reply to Campos and Muñoz: Why phosphate is a bad buffer for guanidinium chloride titrations (2013) (5)
- Intramolecular general acid catalysis of ester hydrolysis by the carboxylic acid group (1967) (4)
- Targeting mutant p53 with PK11007: A new approach for the treatment of patients with triple-negative breast cancer? (2017) (4)
- Redesigning enzymes by site-directed mutagenesis. (1985) (4)
- Altering the Structure of Enzymes by Site-Directed Mutagenesis (1988) (4)
- Chemical basis of biological specificity (1982) (4)
- Single-stranded M13 DNA: use as a cloning vector. (1986) (4)
- S100B (S100 calcium binding protein B) (2008) (3)
- Carl-Ivar Brändén 1934–2004 (2004) (3)
- Max Ferdinand Perutz OM FRS (2002) (3)
- Rescue of the p53 tumor suppressor by a rationally designed molecule. (2004) (3)
- Refolding chromatography with immobilized mini-chaperones ( protein y renaturation y folding y GroEL y hsp 60 ) (1997) (3)
- An NMR study on the beta-hairpin region of barnase. (1996) (3)
- Φ‐Value Analysis of Protein Folding Transition States (2011) (3)
- ReviewProtein Folding and Unfolding at Atomic Resolution (2002) (3)
- Intramolecular nucleophilic catalysis of ester hydrolysis by the carboxylate group (1967) (3)
- Stability and solvation of Thr/Ser to Ala and Gly mutations at the N‐cap of α‐helices (1994) (3)
- Mechanism of the -chymotrypsin-catalyzed hydrolysis of specific amide substrates. (1972) (3)
- Genetic dissection of tyrosyl-tRNA synthetase. (1984) (2)
- Energy expenditure in the editing mechanism of protein synthesis [proceedings]. (1977) (2)
- Structural insights in the folding of small single-domain proteins. (2003) (2)
- COSMIC analysis of the major alpha-helix of barnase during folding. (1991) (2)
- Jubilee Lecture. Pathway and stability of protein folding. (1994) (2)
- Engineering of tyrosyl tRNA synthetase. (1985) (2)
- Molecular Functions of Disordered Proteins (2009) (2)
- University of Groningen Tumor Suppressor p 53 Slides on DNA with Low Friction and High Stability (2017) (2)
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences: 356 (1406) (2001) (2)
- Crystallographic analysis of Phe-->Leu substitution in the hydrophobic core of barnase. (1994) (2)
- Stability and solvation of Thr/Ser to Ala and Gly mutations at the N-cap of alpha-helices. (1994) (2)
- Prediction of Disorder (2009) (1)
- NF‐κB Rel subunit exchange on a physiological timescale (2021) (1)
- How and why to publish in PNAS. (2005) (1)
- Indirect Techniques for Recognizing and Characterizing Protein Disorder (2009) (1)
- Sequence-Dependent Kinetics of One-Dimensional Diffusion of p53 on DNA (2009) (1)
- NMR 15N RELAXATION AND STRUCTURAL STUDIES REVEAL CONFORMATIONAL EXCHANGE IN BARSTAR C40/82A, 30 STRUCTURES (1997) (1)
- Structure on the Move (2001) (1)
- Protein folding - Preface (1995) (1)
- Structure and mechanism in protein science (book review) (1999) (1)
- Extension of the Structure-Function Paradigm (2009) (1)
- Solution structure of ASPP2 N-terminus (2007) (1)
- Structure of the C-terminal sterile a-motif (SAM) domain of human p73a (2001) (1)
- Spectroscopic Techniques for Characterizing Disorder (2009) (1)
- [Folding mechanism and folding rate]. (2001) (1)
- Toward a mechanism for GroELGroES chaperone activity : An ATPase-gated and-pulsed folding and annealing cage ( protein folding / hsp 60 / cpn 60 / barnase ) (2005) (1)
- Abstract 2472: Small-molecule-induced reactivation of mutant p53 in cancer cells. (2013) (1)
- STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-dimethoxy- 2-methylbenzothiazole (2010) (0)
- Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions (2005) (0)
- human p53 core domain mutant T123A-M133L-H168R-V203A-N239Y-R249S- N268D (2005) (0)
- BARNASE WILDTYPE STRUCTURE AT PH 9.0 (1995) (0)
- Abstract IA-8: p53: From structure to drug discovery (2009) (0)
- Human Gelsolin Domain 2 with a Cd2+ bound (2002) (0)
- Structural Disorder and Disease (2009) (0)
- Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state folding transitions (2005) (0)
- 3.1 Combining Simulation and Experiment to Map Protein Folding (2012) (0)
- Correction: Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus (2018) (0)
- YAP65 WW domain S24-Amino-Ethylsulfanyl-Acetic Acid mutant (2001) (0)
- BARNASE MUTANT WITH ILE 96 REPLACED BY ALA (1995) (0)
- Deconvoluting protein folding structural ensembles using X-ray scattering, NMR spectroscopy and molecular dynamics simulation (2014) (0)
- Competition and Complex Formation Between P53, Mdm2 and the P300 Zinc Finger CH3 (2010) (0)
- Solution structure of Engrailed homeodomain L16A mutant (2005) (0)
- Studying Enzyme-Substrate Interactions by Site-Directed Mutagenesis (1984) (0)
- Bound Bacterial Glycolipid The Crystal Structure of Human CD 1 b with a (2004) (0)
- Structure of the p53 core domain mutant Y220C bound to the stabilizing small-molecule drug PhiKan083 (2012) (0)
- is increased by GroES (1991) (0)
- Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D (2005) (0)
- Role of the Conformational Flexibility on the Substrate Recognition of Molecular Chaperone DnaK (2001) (0)
- Crystal structure of the DNA-binding domain of human p53 with extended N terminus (2011) (0)
- Identification of substrate binding site of GroEL minichaperone in solution (1999) (0)
- Correlation between folding-mechanism and folding-rate in protein folding (2000) (0)
- Ligand Binding and Enzymic Catalysis Coupled through Subunits in Tyros yl-t RNA S yn t hetaset (2001) (0)
- backbone resonance assignments of p53 N-terminal transactivation domain (1-93) (2011) (0)
- Exploiting Transient Prote in States for the Design of Small-Molecule Stabilizers of Mutant p 53 Highlights (0)
- Human p53 core domain mutant M133L-V203A-Y220C-N239Y-N268D (2006) (0)
- DNA polymerase accuracy and spontaneous mutation rates : Frequencies of purinepurine , purinepyrimidine , and pyrimidine pyrimidine mismatches during DNA replication ( DNA polymerase mI holoenzyme / bacteriophage 4 X 174 / editing / transitions / transversions ) (0)
- STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-amino substituted benzothiazole scaffold (2010) (0)
- A Guide to Measuring and Interpreting Φ‐values (2008) (0)
- Catalytic dissection of an enzyme active site (1986) (0)
- Fragments de proteine chaperon (1997) (0)
- Structure of the p53 cancer mutant Y220C in complex with 2-hydroxy-3, 5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid (2015) (0)
- p53 cancer mutant Y220C with Cys182 alkylation (2016) (0)
- COMPLEX OF TWO FRAGMENTS OF CI2, RESIDUES 1-40 AND 41-64 (1996) (0)
- U11-48K CHHC Zn-finger protein domain (2009) (0)
- substances. Ehrlich's description of specificity (1982) (0)
- Enzyme catalysis - lessons learned from protein engineering (1987) (0)
- A FAMILY OF LONGCASE MOVEMENTS WITH AN EARLY ANCHOR ESCAPEMENT (2011) (0)
- p53 cancer mutant Y220C im complex with compound MB577 (2018) (0)
- Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution. (2003) (0)
- A Brief History of Protein Disorder (2009) (0)
- BARNASE WILDTYPE STRUCTURE AT PH 7.5 FROM A CRYO_COOLED CRYSTAL AT 100K (1998) (0)
- GROEL (HSP60 CLASS) FRAGMENT (APICAL DOMAIN) COMPRISING RESIDUES 191-376, MUTANT WITH ALA 262 REPLACED WITH LEU AND ILE 267 REPLACED WITH MET (1997) (0)
- Structure of Lys120-acetylated p53 core domain (2011) (0)
- Submillisecond events in protein folding ( barstar / relaxation kinetics / cold denaturation / protein engineering ) (2005) (0)
- STAPHYLOCOCCAL PROTEIN A, B-DOMAIN, Y15W MUTANT, NMR, 25 STRUCTURES (2004) (0)
- System for Studying Cancer Mutations p53 as a Model Drosophila Evaluating Protein Structure and Folding (2014) (0)
- Reply to Campos et al.: Direct observation versus ambiguous kinetics and thermodynamics (2009) (0)
- Folding study of barstar by the T-junp method (1999) (0)
- COMPLEX OF TWO FRAGMENTS OF CI2 [(1-40)(DOT)(41-64)] (1996) (0)
- human p53 core domain mutant M133L-H168R-V203A-N239Y-R249S-N268D (2005) (0)
- BARNASE MUTANT WITH ILE 88 REPLACED BY ALA (1995) (0)
- The Contribution of Intra-Loop Hydrogen Bonds to Protein Stability Revealed by Two Mutant Crystal Structures of Barnase (1993) (0)
- GROEL (HSP60 CLASS) FRAGMENT COMPRISING RESIDUES 191-345 (1997) (0)
- BARNASE A43C/S80C DISULFIDE MUTANT (1995) (0)
- Chemical structure and biological activity of enzymes (1976) (0)
- ANALYSIS OF STRUCTURE‐ACTIVITY RELATIONS IN ENZYMES USING PROTEIN ENGINEERING (1984) (0)
- Design, construction, and properties of novel protein molecules : proceedings of a Royal Society discussion meeting, held on 5 and 6 June 1985 (1986) (0)
- Closed dimer of human ATM (Ataxia telangiectasia mutated) (2017) (0)
- HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D (2009) (0)
- Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L (2006) (0)
- Principles of Protein Structure and Function (2009) (0)
- In vivo activities of GroEL minichaperones (protein foldingyheat shockyprotein biosynthesisyhsp60ycpn60) (1998) (0)
- Protein engineering: basic research and biotechnology (1993) (0)
- Biological Processes Enriched in Disorder (2009) (0)
- Corrigendum to “Conservation of Transition State Structure in Fast Folding Peripheral Subunit-Binding Domains” [J. Mol. Biol. 383 (2008) 224–237] (2009) (0)
- Single-molecule Studies Of p53 Sliding Along DNA (2009) (0)
- Introductory Remarks to the Third Session (1981) (0)
- Evolution and Prevalence of Disorder (2009) (0)
- Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D (2006) (0)
- Catalytic Mechanisms Revealed by Protein Engineering of Tyrosyl-tRNA Synthetase (1988) (0)
- Conversion of two-state to multi-state folding kinetics on fusion of two protein foldons 1 1 Edited (2000) (0)
- Stability studies of p53 tumour suppressor mutants (2000) (0)
- DELETION OF A BURIED SALT-BRIDGE IN BARNASE (1998) (0)
- University of Groningen Tumor Suppressor p53 Slides on DNA with Low Friction and High Stability Tafvizi, (2008) (0)
- CRYSTAL STRUCTURE OF ENGRAILED HOMEODOMAIN MUTANT K52A (2003) (0)
- Galina Selivanova Reviews (2007) (0)
- THE SLOW-EXCHANGE CORE AND PROTEIN FOLDING. AUTHORS' REPLY (1998) (0)
- BARNASE MUTANT WITH LEU 14 REPLACED BY ALA (1995) (0)
- The design of a molecular fixture for cryo-EM structure 1 determination 2 (2018) (0)
- BARNASE T70C/S92C DISULFIDE MUTANT (1995) (0)
- THE STUDY AND REDESIGN OF ENZYMES BY PROTEIN ENGINEERING (1986) (0)
- MECHANISMUS DER DURCH ALPHA‐CHYMOTRYPSIN KATALYSIERTEN HYDROLYSE VON AMIDEN, PH‐ABHAENGIGKEIT VON K(C) UND K(M) (MICHAELISKONSTANTE), KINETISCHER NACHWEIS EINES INTERMEDIAERPRODUKTES (1972) (0)
- The Role of Separate Domains and of Individual Amino-Acids in Enzyme Catalysis, Studied by Site-Directed Mutagenesis (1987) (0)
- FREIE ENTHALPIEN DER HYDROLYSE VON AMIDEN UND PEPTIDEN IN WAESSRIGER LOESUNG BEI 25 GRAD (1971) (0)
- BARNASE MUTANT WITH ILE 76 REPLACED BY ALA (1995) (0)
- The deleterious effect of polyglutamine aggregation in cell models of Huntington's disease. (2000) (0)
- BARNASE S85C/H102C DISULFIDE MUTANT (1995) (0)
- SAP domain from Tho1: L31W (fluorophore) mutant (2010) (0)
- Fidelity of DNA replication in vitro. (1984) (0)
- Energy transfer and specific fluorescence quenching effects in barnase, studied via multifrequency phase-fluorometry of tryptophan mutants (1992) (0)
- Replication of ΦX174 DNA by Calf Thymus DNA Polymerase-α: Measurement of Error Rates at the Amber-16 Codon (1984) (0)
- human p53 core domain mutant M133L-H168R-V203A-N239Y-N268D (2005) (0)
- BARNASE WILDTYPE STRUCTURE AT PH 6.0 (1995) (0)
- Proteomic Approaches for the Identification of IDPs (2009) (0)
- Designing new enzymes (2000) (0)
- Open protomer of human ATM (Ataxia telangiectasia mutated) (2017) (0)
- U11-48K CHHC ZN-FINGER DOMAIN (2009) (0)
- Concluding comment:–Fersht (1987) (0)
- Understanding the Effects of Cancer-Associated Mutations in the Tumor Suppressor Protein p53: Structural Consequences of Mutations and Possible Ways of Rescuing Oncogenic Mutants (2007) (0)
- ChemBioChem@20—Some Reflections (2019) (0)
- Analysis of Protein Interactions by Site-Directed Mutagenesis (1999) (0)
- Nuclear Magnetic Resonance (2009) (0)
- Protein and nucleic acid engineering. Recent French contributions. Part I. (1990) (0)
- NMR structure of the FF domain L24A mutant's folding transition state (2011) (0)
- The catalytic activity of the inactive conformation of delta-chymotrypsin. (1973) (0)
- Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan784 (2012) (0)
- Crystal structure of N-acetylneuraminate lyase from E. coli mutant L142R in complex with b-hydroxypyruvate (2003) (0)
- Interfaces: Two Worlds Unite (2009) (0)
- IDPs under Conditions Approaching In Vivo (2009) (0)
- CRYSTAL STRUCTURE OF THE HEXA-SUBSTITUTED MUTANT OF THE MOLECULAR CHAPERONIN GROEL APICAL DOMAIN (2000) (0)
- Peripheral-subunit from mesophilic, thermophilic and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions (2005) (0)
- Enzymic catalysis : proceedings of a Royal Society Discussion Meeting held on 5 and 6 December, 1990 (1991) (0)
- Structure of IDPs (2009) (0)
- RK. VON NUCLEOPHILEN REAGENZIEN MIT ACYLIERENDEN AGENZIEN EXTREMER REAKTIVITAET UND NICHTREAKTIVITAET, WECHSELBEZIEHUNG ZWISCHEN DEN BETA-WERTEN BEI VARIATION DER ANGREIFENDEN UND ABSPALTENDEN GRUPPE (1970) (0)
- Replication of phi X174 DNA by calf thymus DNA polymerase-alpha: measurement of error rates at the amber-16 codon. (1984) (0)
- ACYLUEBERTRAGUNGS-RK. VON AMIDEN UND ESTERN MIT ALKOHOLEN UND THIOALKOHOLEN, BEZUGSSYST. FUER SERIN- UND CYSTEIN-PROTEINASEN, N-PROTONIERUNG VON AMIDEN UND AMID-IMIDAT-GLEICHGEWICHTE (1971) (0)
- ACETYLPYRIDINIUMION-ZWISCHENPRODUKTE BEI DER DURCH PYRIDINE KATALYSIERTEN HYDROLYSE UND ACYLUEBERTRAGUNGSRK. VON ACETANHYDRID, BEOBACHTUNG, KINETIK, WECHSELBEZIEHUNG ZWISCHEN STRUKTUR UND REAKTIVITAET UND EFFEKTE VON KONZENTRIERTEN SA (1970) (0)
- STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(trifluoromethyl)benzene-1,2-diamine (2010) (0)
- Solution structure of human p53 DNA binding domain. (2006) (0)
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