Alan R. Shuldiner
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Alan R. Shuldiner's Degrees
- PhD Human Genetics Johns Hopkins University
- Doctorate Medicine Johns Hopkins University
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(Suggest an Edit or Addition)Alan R. Shuldiner's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Genetic studies of body mass index yield new insights for obesity biology (2015) (3549)
- Discovery and Refinement of Loci Associated with Lipid Levels (2013) (2475)
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (2010) (2087)
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index (2010) (2011)
- Hundreds of variants clustered in genomic loci and biological pathways affect human height (2010) (1961)
- Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk (2011) (1928)
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes (2012) (1839)
- Defining the role of common variation in the genomic and biological architecture of adult human height (2014) (1805)
- Newly identified loci that influence lipid concentrations and risk of coronary artery disease (2008) (1626)
- Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. (2009) (1481)
- New genetic loci link adipose and insulin biology to body fat distribution (2014) (1227)
- Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index (2010) (1179)
- Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture (2012) (1045)
- Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility (2014) (933)
- Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (2010) (897)
- Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits (2011) (842)
- Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update (2013) (837)
- Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. (2006) (806)
- TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. (2006) (796)
- Common variants associated with plasma triglycerides and risk for coronary artery disease (2013) (767)
- Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways (2012) (758)
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance (2012) (756)
- New loci associated with kidney function and chronic kidney disease (2010) (754)
- Omentin Plasma Levels and Gene Expression Are Decreased in Obesity (2007) (701)
- Genome-wide association analyses identify 18 new loci associated with serum urate concentrations (2012) (678)
- A Null Mutation in Human APOC3 Confers a Favorable Plasma Lipid Profile and Apparent Cardioprotection (2008) (631)
- Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. (1995) (603)
- Genetic Variation in the β3-Adrenergic Receptor and an Increased Capacity to Gain Weight in Patients with Morbid Obesity (1995) (588)
- Unique lipoprotein phenotype and genotype associated with exceptional longevity. (2003) (562)
- Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease (2017) (537)
- The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2015) (532)
- Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies (2010) (477)
- Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels (2011) (476)
- Molecular Scanning of the Human Peroxisome Proliferator Activated Receptor γ (hPPARγ) Gene in Diabetic Caucasians: Identification of a Pro12Ala PPARγ2 Missense Mutation (1997) (469)
- Implementing genomic medicine in the clinic: the future is here (2013) (463)
- Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study (2016) (445)
- Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450–2C19 (CYP2C19) Genotype and Clopidogrel Therapy (2011) (429)
- New gene functions in megakaryopoiesis and platelet formation (2011) (423)
- A Protein‐Truncating HSD17B13 Variant and Protection from Chronic Liver Disease (2018) (422)
- FTO genotype is associated with phenotypic variability of body mass index (2012) (407)
- Common variants in the GDF5-UQCC region are associated with variation in human height (2008) (400)
- Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function (2016) (388)
- Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease. (2016) (372)
- Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits (2013) (365)
- Telomere length is paternally inherited and is associated with parental lifespan (2007) (362)
- Seventy-five genetic loci influencing the human red blood cell (2012) (357)
- Acute-Phase Serum Amyloid A: An Inflammatory Adipokine and Potential Link between Obesity and Its Metabolic Complications (2006) (337)
- A rapid and versatile method to synthesize internal standards for competitive PCR. (1993) (328)
- Ethical and Practical Guidelines for Reporting Genetic Research Results to Study Participants: Updated Guidelines from a National Heart, Lung, and Blood Institute Working Group (2010) (324)
- Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. (1998) (322)
- Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta. (1993) (319)
- Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile (2011) (313)
- Genetic identification of familial hypercholesterolemia within a single U.S. health care system (2016) (307)
- Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians. (1998) (306)
- Polymorphisms in the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in the Amish (2006) (306)
- Whole-genome association study identifies STK39 as a hypertension susceptibility gene (2009) (300)
- Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders (2013) (299)
- Physical activity and the association of common FTO gene variants with body mass index and obesity. (2008) (294)
- Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure (2020) (288)
- Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction (2011) (286)
- Resistin, obesity, and insulin resistance--the emerging role of the adipocyte as an endocrine organ. (2001) (282)
- Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. (2012) (282)
- NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium (2009) (281)
- Meta-analysis of genome-wide association data identifies two loci influencing age at menarche (2009) (276)
- Genetic loci influencing kidney function and chronic kidney disease (2010) (266)
- Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization (2014) (260)
- Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation. (1997) (255)
- Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program (2010) (244)
- Exome sequencing and characterization of 49,960 individuals in the UK Biobank (2020) (244)
- New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk (2016) (242)
- The Pharmacogenetics Research Network: From SNP Discovery to Clinical Drug Response (2007) (242)
- Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. (2012) (238)
- Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. (2018) (221)
- Comparative studies of resistin expression and phylogenomics in human and mouse. (2003) (215)
- Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque (2011) (214)
- CUBN is a gene locus for albuminuria. (2011) (214)
- Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. (1995) (214)
- Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention. (2018) (210)
- Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. (2002) (207)
- Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans (2006) (206)
- Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome (2012) (204)
- Genetic evidence of assortative mating in humans (2017) (199)
- A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function (2013) (193)
- Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study (2011) (185)
- Global implementation of genomic medicine: We are not alone (2015) (183)
- The IGNITE network: a model for genomic medicine implementation and research (2015) (180)
- Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function (2012) (180)
- Identification of Novel Candidate Genes for Type 2 Diabetes From a Genome-Wide Association Scan in the Old Order Amish (2007) (176)
- Diabetes in the Old Order Amish: characterization and heritability analysis of the Amish Family Diabetes Study. (2000) (174)
- Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. (2008) (170)
- Heritability of life span in the Old Order Amish. (2001) (167)
- Exome sequencing and analysis of 454,787 UK Biobank participants (2021) (166)
- The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Overcoming Challenges of Real‐World Implementation (2013) (166)
- Pharmacogenomics: Challenges and Opportunities (2006) (162)
- Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank (2020) (162)
- A Central Role for GRB10 in Regulation of Islet Function in Man (2014) (159)
- Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults (2017) (153)
- Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24. (2003) (151)
- Elabela-Apelin Receptor Signaling Pathway is Functional in Mammalian Systems (2015) (149)
- Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes. (2014) (146)
- Loci influencing blood pressure identified using a cardiovascular gene-centric array. (2013) (145)
- Directional dominance on stature and cognition in diverse human populations (2015) (144)
- Effect of the Pro12Ala variant of the human peroxisome proliferator-activated receptor gamma 2 gene on adiposity, fat distribution, and insulin sensitivity in Japanese men. (1998) (140)
- PharmGKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 19 (2012) (140)
- The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes (2000) (138)
- The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response (2013) (137)
- Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function. (2008) (135)
- Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. (2011) (133)
- Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. (2009) (132)
- DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. (2017) (132)
- Genetic variation in the peroxisome proliferator-activated receptor-gamma2 gene (Pro12Ala) affects metabolic responses to weight loss and subsequent weight regain. (2001) (130)
- The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study. (2008) (127)
- Adiponectin levels and genotype: a potential regulator of life span in humans. (2008) (127)
- Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis (2020) (127)
- Whole exome sequencing and characterization of coding variation in 49,960 individuals in the UK Biobank (2019) (126)
- Eating behavior in the Old Order Amish: heritability analysis and a genome-wide linkage analysis. (2002) (125)
- A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference (2002) (125)
- Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes (2015) (121)
- A mutation of the b3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride (1997) (118)
- Metformin Pharmacogenomics: Current Status and Future Directions (2014) (115)
- The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems (2017) (115)
- Genome-wide association study of kidney function decline in individuals of European descent (2014) (114)
- Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene. (2005) (111)
- A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans. (1998) (111)
- cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase. (2002) (107)
- Extension of Type 2 Diabetes Genome-Wide Association Scan Results in the Diabetes Prevention Program (2008) (106)
- Rethinking the genetic basis for comorbidity of schizophrenia and type 2 diabetes (2010) (105)
- Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification, Metformin Treatment, or Standard Care in the Diabetes Prevention Program (2012) (105)
- Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (2011) (104)
- Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies (2012) (102)
- QTL influencing blood pressure maps to the region of PPH1 on chromosome 2q31-34 in Old Order Amish. (2000) (102)
- A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians. (2003) (101)
- Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation (2016) (100)
- The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans (2000) (99)
- Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. (2005) (98)
- COL4A1 Is Associated With Arterial Stiffness by Genome-Wide Association Scan (2009) (98)
- Variable Bone Fragility Associated With an Amish COL1A2 Variant and a Knock-in Mouse Model (2009) (97)
- Hybrid DNA artifact from PCR of closely related target sequences. (1989) (97)
- SNP43 of CAPN10 and the risk of type 2 Diabetes in African-Americans: the Atherosclerosis Risk in Communities Study. (2002) (97)
- Genome-wide scan of obesity in the Old Order Amish. (2001) (97)
- Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: the Atherosclerosis Risk in Communities Study. (1999) (96)
- Chromosomal localization and partial genomic structure of the human peroxisome proliferator activated receptor-gamma (hPPAR gamma) gene. (1997) (96)
- Fatty acid binding protein-2 gene variants and insulin resistance: gene and gene-environment interaction effects. (2002) (96)
- Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish. (2008) (93)
- Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study (2009) (92)
- Common Genetic Variation in the 3′-BCL11B Gene Desert Is Associated With Carotid-Femoral Pulse Wave Velocity and Excess Cardiovascular Disease Risk: The AortaGen Consortium (2012) (91)
- Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes (2018) (91)
- Interactions Between Variants in the β3-Adrenergic Receptor and Peroxisome Proliferator–Activated Receptor-γ2 Genes and Obesity (2001) (90)
- Genotyping: one piece of the puzzle to personalize antiplatelet therapy. (2010) (90)
- The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to cyp 2c19*2 genotype: first experience in patients (2010) (89)
- Searching for human longevity genes: the future history of gerontology in the post-genomic era. (2001) (88)
- Pancreatic thread protein is mitogenic to pancreatic-derived cells in culture. (1996) (88)
- Associations between Genetic Variants in the NOS1AP (CAPON) Gene and Cardiac Repolarization in the Old Order Amish (2007) (87)
- Genetic Variation in PEAR1 Is Associated With Platelet Aggregation and Cardiovascular Outcomes (2013) (87)
- Platelet aggregation pathway. (2011) (87)
- Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of Diabetes (TRIPOD) study. (2004) (86)
- Implementation of pharmacogenetics: The University of Maryland personalized anti‐platelet pharmacogenetics program (2014) (86)
- Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish. (2005) (86)
- Paraoxonase 1 (PON1) Gene Variants Are Not Associated With Clopidogrel Response (2011) (86)
- Clopidogrel: A Case for Indication‐Specific Pharmacogenetics (2012) (85)
- Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity (2021) (85)
- Does having children extend life span? A genealogical study of parity and longevity in the Amish. (2006) (84)
- Genetic Variation at NCAN Locus Is Associated with Inflammation and Fibrosis in Non-Alcoholic Fatty Liver Disease in Morbid Obesity (2013) (83)
- Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations (2021) (83)
- The relation between CYP2C19 genotype and phenotype in stented patients on maintenance dual antiplatelet therapy. (2011) (82)
- Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver (2004) (82)
- Serum 25-Hydroxyvitamin D Levels Are Not Associated with Subclinical Vascular Disease or C-Reactive Protein in the Old Order Amish (2009) (80)
- Genotype-based changes in serum uric acid affect blood pressure. (2012) (79)
- Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease (2017) (78)
- The role of peroxisome proliferator-activated receptor gamma in diabetes and obesity (2002) (78)
- Association of Single Nucleotide Polymorphisms on Chromosome 9p21.3 With Platelet Reactivity: A Potential Mechanism for Increased Vascular Disease (2010) (78)
- Determinants of Coronary Artery and Aortic Calcification in the Old Order Amish (2007) (76)
- Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos. (1991) (76)
- A genome-wide scan of serum lipid levels in the Old Order Amish. (2004) (76)
- The C Allele of ATM rs11212617 Does Not Associate With Metformin Response in the Diabetes Prevention Program (2012) (74)
- Association between bilirubin and cardiovascular disease risk factors: using Mendelian randomization to assess causal inference (2012) (74)
- The relationship between parity and bone mineral density in women characterized by a homogeneous lifestyle and high parity. (2005) (73)
- Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish. (2010) (73)
- Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity. (2001) (73)
- Variants in Scavenger Receptor Class B Type I Gene Are Associated with HDL Cholesterol Levels in Younger Women (2007) (72)
- The CYP2C19*17 variant is not independently associated with clopidogrel response (2013) (72)
- Association of the Vitamin D Metabolism Gene CYP24A1 With Coronary Artery Calcification (2010) (71)
- Pro12Ala of the peroxisome proliferator-activated receptor-gamma2 gene is associated with lower serum insulin levels in nonobese African Americans: the Atherosclerosis Risk in Communities Study. (2003) (69)
- Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish. (2004) (69)
- Genetic and environmental influences on bone mineral density in pre- and post-menopausal women (2005) (68)
- Associations of autozygosity with a broad range of human phenotypes (2019) (68)
- Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. (2012) (67)
- Purine Pathway Implicated in Mechanism of Resistance to Aspirin Therapy: Pharmacometabolomics-Informed-Pharmacogenomics (2013) (66)
- Association between obesity and a polymorphism in the β1-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women (2002) (64)
- Impaired capacity to lose visceral adipose tissue during weight reduction in obese postmenopausal women with the Trp64Arg beta3-adrenoceptor gene variant. (2000) (64)
- Mutations in Gng3lg and AGPAT2 in Berardinelli-Seip congenital lipodystrophy and Brunzell syndrome: phenotype variability suggests important modifier effects. (2004) (61)
- Stroke Genetics Network (SiGN) Study: Design and Rationale for a Genome-Wide Association Study of Ischemic Stroke Subtypes (2013) (60)
- Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals (2021) (59)
- Variation in the Lamin A/C Gene: Associations With Metabolic Syndrome (2004) (58)
- PCR-induced (ligase-free) subcloning: a rapid reliable method to subclone polymerase chain reaction (PCR) products. (1990) (58)
- Quantitative Trait Loci for BMD Identified by Autosome‐Wide Linkage Scan to Chromosomes 7q and 21q in Men from the Amish Family Osteoporosis Study (2006) (58)
- Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (2020) (58)
- The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults. (2008) (57)
- The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish. (2005) (56)
- The Gln223 Arg and Lys656 Asn Polymorphisms in the Human Leptin Receptor Do Not Associate With Traits Related to Obesity (1997) (56)
- Obesity gene variant and elite endurance performance. (2001) (56)
- Does genetic testing for obesity influence confidence in the ability to lose weight? A pilot investigation. (2001) (56)
- TM6SF2 rs58542926 impacts lipid processing in liver and small intestine (2017) (55)
- Obesity-related phenotypes and the beta3-adrenoceptor gene variant in postmenopausal women. (1999) (55)
- The insulin-like growth factor I (IGF-I) gene is expressed in chick embryos during early organogenesis. (1990) (54)
- The Pro12Ala variant of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with measures of obesity in Mexican Americans. (2000) (53)
- RNA template-specific PCR: an improved method that dramatically reduces false positives in RT-PCR. (1991) (53)
- Association between body fat response to exercise training and multilocus ADR genotypes. (2004) (53)
- Monogenic Diabetes in Overweight and Obese Youth Diagnosed with Type 2 Diabetes: The TODAY Clinical Trial (2017) (53)
- Pharmacometabolomics Reveals That Serotonin Is Implicated in Aspirin Response Variability (2014) (52)
- Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study). (2009) (52)
- Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q (2006) (52)
- Role of the beta 3-adrenergic receptor locus in obesity and noninsulin-dependent diabetes among members of Caucasian families with a diabetic sibling pair. (1996) (51)
- Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort). (2013) (51)
- Habitual sleep/wake patterns in the Old Order Amish: heritability and association with non-genetic factors. (2011) (51)
- Profiling and leveraging relatedness in a precision medicine cohort of 92,455 exomes (2017) (51)
- Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania (2012) (50)
- Assessment of sex‐specific genetic and environmental effects on bone mineral density (2004) (50)
- Determination of gene dosage by a quantitative adaptation of the polymerase chain reaction (gd-PCR): rapid detection of deletions and duplications of gene sequences. (1994) (50)
- Two nonallelic insulin genes in Xenopus laevis are expressed differentially during neurulation in prepancreatic embryos. (1991) (49)
- Pancreatic regeneration (reg) gene expression in a rat model of islet hyperplasia. (1996) (48)
- Molecular scanning for mutations in the beta 3-adrenergic receptor gene in Nauruans with obesity and noninsulin-dependent diabetes mellitus. (1996) (48)
- Pharmacogenomics: Application to the Management of Cardiovascular Disease (2011) (48)
- TCF7L2 variants associate with CKD progression and renal function in population-based cohorts. (2008) (48)
- Hyperinsulinemia is associated with altered insulin receptor mRNA splicing in muscle of the spontaneously obese diabetic rhesus monkey. (1994) (48)
- Pharmacogenomic Polygenic Response Score Predicts Ischemic Events and Cardiovascular Mortality in Clopidogrel-Treated Patients. (2019) (47)
- Effects of Genetic Variants Previously Associated with Fasting Glucose and Insulin in the Diabetes Prevention Program (2012) (47)
- Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update (2022) (46)
- Identification of an Interactive Effect of β3- and α2b-Adrenoceptor Gene Polymorphisms on Fat Mass in Caucasian Women (2001) (46)
- The genetics of obesity. (2003) (46)
- No effect of the Trp64Arg beta(3)-adrenoceptor gene variant on weight loss, body composition, or energy expenditure in obese, caucasian postmenopausal women. (2002) (45)
- TRP64ARG β3-adrenergic receptor and obesity in Mexican Americans (1997) (45)
- Endurance training-induced changes in the insulin response to oral glucose are associated with the peroxisome proliferator-activated receptor-gamma2 Pro12Ala genotype in men but not in women. (2005) (45)
- Evaluation of A2BP1 as an Obesity Gene (2010) (44)
- Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels. (2015) (44)
- Anti-inflammatory effects of simvastatin on adipokines in type 2 diabetic patients with carotid atherosclerosis (2009) (43)
- Xenopus laevis contains two nonallelic preproinsulin genes. cDNA cloning and evolutionary perspective. (1989) (42)
- Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes (2021) (41)
- Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again. (2004) (41)
- Exploring the genetics of longevity in the Old Order Amish (2005) (40)
- FABP2 Ala54Thr genotype is associated with glucoregulatory function and lipid oxidation after a high-fat meal in sedentary nondiabetic men and women. (2007) (40)
- Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease (2022) (40)
- Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease (2022) (40)
- Polymorphism in the calsequestrin 1 (CASQ1) gene on chromosome 1q21 is associated with type 2 diabetes in the old order Amish. (2004) (39)
- CYP2C19 Metabolizer Status and Clopidogrel Efficacy in the Secondary Prevention of Small Subcortical Strokes (SPS3) Study (2015) (39)
- A Common Variant in the Telomerase RNA Component Is Associated with Short Telomere Length (2010) (39)
- Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension (2018) (38)
- The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature (2017) (38)
- Isolation and characterization of two different insulins from an amphibian, Xenopus laevis. (1989) (38)
- The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: a pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort (2010) (38)
- Longevity genes: from primitive organisms to humans. (2003) (38)
- Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction (2019) (38)
- Genomic characterization of the coding region of the human type II 5′-deiodinase gene (1998) (38)
- Genomic diagnostics within a medically underserved population: efficacy and implications (2017) (38)
- Interactions between variants in the beta3-adrenergic receptor and peroxisome proliferator-activated receptor-gamma2 genes and obesity. (2001) (38)
- A genome-wide scan for autoimmune thyroiditis in the Old Order Amish: replication of genetic linkage on chromosome 5q11.2-q14.3. (2003) (37)
- Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2016) (37)
- A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density (2012) (37)
- Activating Transcription Factor 6 (ATF6) Sequence Polymorphisms in Type 2 Diabetes and Pre-Diabetic Traits (2007) (37)
- Electron emission and luminescence owing to plastic deformation of ionic crystals (1995) (36)
- Clinical and Molecular Prevalence of Lipodystrophy in an Unascertained Large Clinical Care Cohort (2019) (36)
- Reduced Incidence of Hip Fracture in the Old Order Amish (2003) (36)
- Molecular scanning for mutations in the insulin receptor substrate‐1 (IRS‐1) gene in Mexican Americans with Type 2 diabetes mellitus (2000) (36)
- Common variants in Mendelian kidney disease genes and their association with renal function. (2013) (35)
- Relationship between Vascular Calcification and Bone Mineral Density in the Old-Order Amish (2007) (35)
- Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor. (2000) (35)
- Consortium ( CPIC ) guidelines for cytochrome P 450-2 C 19 ( CYP 2 C 19 ) genotype and clopidogrel therapy (2011) (35)
- Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers (2014) (35)
- Hypertrophy‐Associated Polymorphisms Ascertained in a Founder Cohort Applied to Heart Failure Risk and Mortality (2011) (35)
- Common Variation in the LMNA Gene (Encoding Lamin A/C) and Type 2 Diabetes (2007) (34)
- Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI Genetics of Lipid Lowering Drugs and Diet Network (GOLDN). (2015) (34)
- A recombinant rat regenerating protein is mitogenic to pancreatic derived cells. (2000) (34)
- Genetic Modulation of Lipid Profiles following Lifestyle Modification or Metformin Treatment: The Diabetes Prevention Program (2012) (33)
- Variants in ARHGEF11, a Candidate Gene for the Linkage to Type 2 Diabetes on Chromosome 1q, Are Nominally Associated With Insulin Resistance and Type 2 Diabetes in Pima Indians (2007) (33)
- A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations (2016) (33)
- Genetic Modulation of Lipid Profiles following Lifestyle Modification or Metformin Treatment: The Diabetes Prevention Program (2012) (33)
- Responding to the clopidogrel warning by the US food and drug administration: real life is complicated. (2010) (33)
- β3-adrenoceptor gene variant in obesity and insulin resistance (1996) (32)
- Accounting for Relatedness in Family Based Genetic Association Studies (2007) (32)
- Physical activity and prevention of type 2 diabetes (2003) (32)
- Effect of zinc supplementation on insulin secretion: interaction between zinc and SLC30A8 genotype in Old Order Amish (2014) (32)
- DASH Score and Subsequent Risk of Coronary Artery Disease: The Findings From Million Veteran Program (2018) (31)
- Inactivating Variants in ANGPTL 4 and Risk of Coronary Artery Disease (2016) (31)
- Pharmacogenetics and Clopidogrel Response in Patients Undergoing Percutaneous Coronary Interventions (2011) (31)
- The association of podocin R229Q polymorphism with increased albuminuria or reduced estimated GFR in a large population-based sample of US adults. (2008) (31)
- Mucus sialylation determines intestinal host-commensal homeostasis (2022) (31)
- Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank (2022) (31)
- Trp64Arg Variant of theβ 3-Adrenoceptor and Insulin Resistance in Obese Postmenopausal Women1 (1998) (31)
- Evidence that Xenopus laevis contains two different nonallelic insulin-like growth factor-I genes. (1990) (31)
- RNA template-specific polymerase chain reaction (RS-PCR): a novel strategy to reduce dramatically false positives. (1990) (31)
- The beta3-adrenergic receptor in the obesity and diabetes prone rhesus monkey is very similar to human and contains arginine at codon 64. (1997) (30)
- Identification of a Variant in KDR Associated with Serum VEGFR2 and Pharmacodynamics of Pazopanib (2014) (30)
- Lack of IRS-1 codon 513 and 972 polymorphism in Pima Indians. (1995) (30)
- The ABCG8 G574R Variant, Serum Plant Sterol Levels, and Cardiovascular Disease Risk in the Old Order Amish (2013) (30)
- Investigations of the Y Chromosome, Male Founder Structure and YSTR Mutation Rates in the Old Order Amish (2007) (30)
- American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome (2015) (30)
- Evidence That Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) on 1q21 is a Type 2 Diabetes Susceptibility Gene in the Old Order Amish (2007) (30)
- Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities (2019) (29)
- Genetic influences on blood pressure response to the cold pressor test: results from the Heredity and Phenotype Intervention Heart Study (2008) (29)
- Differential expression of reg-I and reg-II genes during aging in the normal mouse. (1996) (29)
- Expression, purification, and initial characterization of human alanine aminotransferase (ALT) isoenzyme 1 and 2 in High-five insect cells. (2008) (28)
- TCF7L2 Polymorphism, Weight Loss and Proinsulin∶Insulin Ratio in the Diabetes Prevention Program (2011) (28)
- The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects (2016) (28)
- Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q (2009) (28)
- Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder. (2015) (28)
- Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits (2012) (28)
- Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1. (2012) (28)
- Circulating CD34+ Cell Count is Associated with Extent of Subclinical Atherosclerosis in Asymptomatic Amish Men, Independent of 10-Year Framingham Risk (2009) (27)
- Pharmacogenomics of Anti-platelet Therapy: How much evidence is enough for clinical implementation? (2013) (27)
- Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study (2009) (27)
- The β3-adrenergic receptor TRP64ARG polymorphism and obesity in Alaskan Eskimos (1997) (27)
- Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn’s Disease (2017) (27)
- Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. (2014) (27)
- Obesity Genes and Gene–Environment–Behavior Interactions: Recommendations for a Way Forward (2008) (27)
- Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogrel response in healthy adults. (2016) (26)
- No effect of the Trp64Arg β3-adrenoceptor variant on in vivo lipolysis in subcutaneous adipose tissue (1997) (26)
- Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. (2012) (26)
- Chronotype and seasonality: morningness is associated with lower seasonal mood and behavior changes in the Old Order Amish. (2015) (26)
- Genetics of insulin resistance (2002) (26)
- An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs (2021) (26)
- Living the Good Life? Mortality and Hospital Utilization Patterns in the Old Order Amish (2012) (25)
- New progress in adipocytokine research (2003) (25)
- Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes (2006) (25)
- Correlation of Circulating MMP-9 with White Blood Cell Count in Humans: Effect of Smoking (2013) (25)
- Altered insulin receptor messenger ribonucleic acid splicing in liver is associated with deterioration of glucose tolerance in the spontaneously obese and diabetic rhesus monkey: analysis of controversy between monkey and human studies. (1996) (24)
- CYP2C19 genotype and cardiovascular events. (2012) (24)
- Familial Hypercholesterolemia and Type 2 Diabetes in the Old Order Amish (2017) (24)
- Molecular investigation of age-related changes in mouse endocrine pancreas. (1996) (23)
- The influence of rare genetic variation in SLC30A8 on diabetes incidence and β-cell function. (2014) (23)
- Pancreatic reg gene expression is inhibited during cellular differentiation. (1997) (23)
- Determinants of Blood Pressure Response to Low‐Salt Intake in a Healthy Adult Population (2011) (23)
- Genome-Wide Association Scan Identifies Variants near Matrix Metalloproteinase (MMP) Genes on Chromosome 11q21–22 Strongly Associated With Serum MMP-1 Levels (2009) (23)
- The CFTR Met 470 Allele Is Associated with Lower Birth Rates in Fertile Men from a Population Isolate (2010) (22)
- Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel: A Study by the International Clopidogrel Pharmacogenomics Consortium (2020) (22)
- Genome‐wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC) (2017) (22)
- Decreased bone mineral density in subjects carrying familial defective apolipoprotein B-100. (2013) (22)
- TRP64ARG beta 3-adrenergic receptor and obesity in Mexican Americans. (1997) (22)
- Gender differences in first and secondhand smoke exposure, spirometric lung function and cardiometabolic health in the old order Amish: A novel population without female smoking (2017) (21)
- Genetic Effects on Postprandial Variations of Inflammatory Markers in Healthy Individuals (2010) (21)
- Mammographic Breast Density—Evidence for Genetic Correlations with Established Breast Cancer Risk Factors (2008) (21)
- FABP2 genotype is associated with insulin sensitivity in older women. (2001) (21)
- Identification of an interactive effect of beta3- and alpha2b-adrenoceptor gene polymorphisms on fat mass in Caucasian women. (2001) (21)
- The two nonallelic insulin-like growth factor-I genes in Xenopus laevis are differentially regulated during development. (1994) (21)
- Educational innovations in clinical pharmacogenomics (2016) (21)
- Thrombin-induced platelet-fibrin clot strength: Relation to high on-clopidogrel platelet reactivity, genotype, and post-percutaneous coronary intervention outcomes (2013) (21)
- Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response. (2017) (21)
- The genetic interface between gestational diabetes and type 2 diabetes (2012) (21)
- Heritability of complex white matter diffusion traits assessed in a population isolate (2016) (21)
- Ligase-free subcloning: a versatile method to subclone polymerase chain reaction (PCR) products in a single day. (1991) (20)
- Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease (2020) (20)
- Comparison of BMI and Physical Activity Between Old Order Amish Children and Non-Amish Children (2013) (20)
- Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116)) (2010) (20)
- Trp64Arg beta3-adrenoceptor: when does a candidate gene become a disease-susceptibility gene? (2001) (20)
- CPT1A methylation is associated with plasma adiponectin. (2017) (19)
- Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles. (2008) (19)
- Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish (2010) (19)
- Heritability of serum sodium concentration: evidence for sex- and ethnic-specific effects. (2012) (18)
- NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality. (2017) (18)
- Competitive reverse-transcriptase polymerase chain reaction without an artificial internal standard. (1995) (18)
- Genetic variation of Glucose Transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) Study (2011) (18)
- Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium. (2021) (18)
- Pharmacogenetic Associations of &bgr;1-Adrenergic Receptor Polymorphisms With Cardiovascular Outcomes in the SPS3 Trial (Secondary Prevention of Small Subcortical Strokes) (2017) (18)
- Regenerating (reg) and insulin genes are expressed in prepancreatic mouse embryos. (1996) (18)
- Genome sequencing unveils a regulatory landscape of platelet reactivity (2019) (18)
- ??2- AND ??3-ADRENERGIC RECEPTOR POLYMORPHISMS AND EXERCISE HEMODYNAMICS IN POSTMENOPAUSAL WOMEN (2001) (17)
- Cardiovascular pharmacogenomics. (2011) (17)
- User-centered design of multi-gene sequencing panel reports for clinicians (2016) (17)
- Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential (2022) (17)
- Genetics of obesity: More complicated than initially thought (2003) (17)
- Seasonality of mood and behavior in the Old Order Amish. (2013) (16)
- Pro115Gln peroxisome proliferator-activated receptor-gamma and obesity. (2000) (16)
- Persistent Staphylococcus aureus Colonization Is Not a Strongly Heritable Trait in Amish Families (2011) (16)
- Reversal of Aging‐Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein‐Protein Interfaces (2018) (16)
- Oxylipid Profile of Low‐Dose Aspirin Exposure: A Pharmacometabolomics Study (2015) (16)
- Prioritizing Approaches to Engage Community Members and Build Trust in Biobanks: A Survey of Attitudes and Opinions of Adults within Outpatient Practices at the University of Maryland (2015) (15)
- Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. (2016) (15)
- Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture (2007) (15)
- Variation in Maturity-Onset Diabetes of the Young Genes Influence Response to Interventions for Diabetes Prevention (2017) (15)
- Expression of the regenerating gene in the pancreas of aging mice. (1994) (15)
- Genetic association analysis of SARS-CoV-2 infection in 455,838 UK Biobank participants (2020) (15)
- Letter by Gurbel et al regarding article, "Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement". (2010) (15)
- Paraoxonase 1 Q192R variant and clopidogrel efficacy: fact or fiction? (2012) (14)
- A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant (2019) (14)
- Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals (2020) (14)
- Beta 3-adrenergic receptor gene variant and lipid metabolism in Pima Indians. (1997) (14)
- Germline Mutations in CIDEB and Protection against Liver Disease. (2022) (14)
- A novel TUFM homozygous variant in a child with mitochondrial cardiomyopathy expands the phenotype of combined oxidative phosphorylation deficiency 4 (2019) (13)
- A Genome-Wide Linkage Scan of Insulin Level–Derived Traits (2007) (13)
- A Template for Authoring and Adapting Genomic Medicine Content in the eMERGE Infobutton Project (2014) (13)
- Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes (2021) (13)
- Beta2- and beta3-adrenergic receptor polymorphisms and exercise hemodynamics in postmenopausal women. (2004) (13)
- Analysis of the peroxisome proliferator activated receptor γ (PPARγ) gene in HAIRAN syndrome with obesity (2000) (13)
- MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk (2020) (13)
- Erratum to “Comparative studies of resistin expression and phylogenomics in human and mouse” [Biochem. Biophys. Res. Commun. 310 (2003) 927–935] (2003) (12)
- On the mechanism of deformation-induced destruction of colour centres (1996) (12)
- Pharmacogenomics of Anti-platelet and Anti-coagulation Therapy (2013) (12)
- Vitamin and supplement use among old order amish: sex-specific prevalence and associations with use. (2015) (12)
- Extent and Distribution of Linkage Disequilibrium in the Old Order Amish (2009) (12)
- Rare genetic coding variants associated with human longevity and protection against age-related diseases (2021) (12)
- Genome-wide association analysis of common genetic variants of resistant hypertension (2018) (12)
- The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin. (2015) (12)
- Analysis of the bereavement effect after the death of a spouse in the Amish: a population-based retrospective cohort study (2014) (12)
- Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation (2019) (12)
- Identifying clinically relevant sources of variability: The clopidogrel challenge (2017) (12)
- A population-specific reference panel empowers genetic studies of Anabaptist populations (2017) (12)
- From Genotype to Phenotype: Nonsense Variants in SLC13A1 Are Associated with Decreased Serum Sulfate and Increased Serum Aminotransferases (2016) (11)
- Familial aggregation of tobacco use behaviors among Amish men. (2014) (11)
- Genetics of Diabetes (2004) (11)
- Molecular Scanning of β-3-Adrenergic Receptor Gene in Total Congenital Lipoatrophic Diabetes Mellitus (1997) (11)
- A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids (2021) (11)
- Autosome-wide linkage analysis of hip structural phenotypes in the Old Order Amish. (2008) (11)
- GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms (2020) (11)
- High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease (2022) (11)
- Hepatic lipase genotype, diabetes risk, and implications for preventative medicine. (2004) (10)
- 1168 IL28B GENETIC VARIATION ASSOCIATED WITH EARLY VIRAL KINETICS AND SVR IN HCV GENOTYPE 1 THE VIRAHEP-C STUDY (2010) (10)
- FABP 2 Ala 54 Thr genotype is associated with glucoregulatory function and lipid oxidation after a high-fat meal in sedentary nondiabetic men and women 1 – 3 (2006) (10)
- A catalog of associations between rare coding variants and COVID-19 outcomes (2020) (10)
- Genomics: Variations in blood lipids (2010) (10)
- Increased usual physical activity is associated with a blunting of the triglyceride response to a high-fat meal. (2019) (10)
- Polyherbal dietary supplementation for prediabetic adults: study protocol for a randomized controlled trial (2019) (10)
- Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene. (2016) (10)
- Characterization of exome variants and their metabolic impact in 6,716 American Indians from Southwest US (2020) (10)
- Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response (2014) (10)
- Common and rare variant associations with clonal haematopoiesis phenotypes (2022) (10)
- Establishing the role of PLVAP in protein-losing enteropathy: a homozygous missense variant leads to an attenuated phenotype (2018) (10)
- The CAPN2/CAPN8 Locus on Chromosome 1q Is Associated with Variation in Serum Alpha-Carotene Concentrations (2016) (10)
- Xenopus laevis oocytes, eggs and tadpoles contain immunoactive insulin. (1994) (9)
- Genetic Variation in PEAR1, Cardiovascular Outcomes and Effects of Aspirin in a Healthy Elderly Population (2020) (9)
- Exome sequencing of 628,388 individuals identifies common and rare variant associations with clonal hematopoiesis phenotypes (2022) (9)
- Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing. (2007) (9)
- Homozygosity for CHEK2 p.Gly167Arg leads to a unique cancer syndrome with multiple complex chromosomal translocations in peripheral blood karyotype (2019) (9)
- Assignment of the human pancreatic regenerating (REG) gene to chromosome 2p12. (1994) (9)
- Paediatric systemic lupus erythematosus as a manifestation of constitutional mismatch repair deficiency (2019) (9)
- Correction: Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults (2017) (9)
- BMI in the Old Order Amish. (2004) (8)
- The beta(3)-adrenergic receptor TRP64ARG polymorphism and obesity in Alaskan Eskimos. (1997) (8)
- Analysis of the peroxisome proliferator activated receptor gamma (PPARgamma) gene in HAIRAN syndrome with obesity. (2000) (8)
- Using Workflow Modeling to Identify Areas to Improve Genetic Test Processes in the University of Maryland Translational Pharmacogenomics Project (2015) (8)
- The Association between Factor XI Deficiency and the Risk of Bleeding, Cardiovascular, and Venous Thromboembolic Events (2021) (8)
- Trp64Arg variant of the beta3-adrenoceptor and insulin resistance in obese postmenopausal women. (1998) (8)
- USE OF GENOME SCANS TO IDENTIFY SUSCEPTIBILITY GENES FOR TYPE 2 DIABETES (2001) (8)
- Cardiovascular risks impact human brain N-acetylaspartate in regionally specific patterns (2019) (8)
- Prevalence, control, and treatment of diabetes, hypertension, and high cholesterol in the Amish (2020) (8)
- Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis. (2018) (8)
- Extension of GWAS results for lipid-related phenotypes to extreme obesity using electronic health record (EHR) data and the Metabochip (2014) (7)
- An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels (2018) (7)
- Clopidogrel Improves Skin Microcirculatory Endothelial Function in Persons With Heightened Platelet Aggregation (2016) (7)
- Next generation sequencing and the classical HLA loci in full heritage Pima Indians of Arizona: Defining the core HLA variation for North American Paleo-Indians. (2019) (7)
- Effect of Serum Zinc and Copper Levels on Insulin Secretion, Insulin Resistance and Pancreatic β cell Dysfunction in US Adults: Findings from the National Health and Nutrition Examination Survey (NHANES) 2011-2012. (2020) (7)
- Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults (2016) (7)
- Lipid Metabolism, Abdominal Adiposity and Cerebral Health in the Amish (2017) (7)
- The IGNITE network: a model for genomic medicine implementation and research (2015) (7)
- Beta 3-adrenoceptor gene variant in obesity and insulin resistance. (1996) (7)
- Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel. (2013) (7)
- Common genetic variants identify targets for COVID-19 and individuals at 1 high risk of severe disease 2 (2021) (7)
- Clopidogrel pharmacogenetics: Beyond candidate genes and genome‐wide association studies (2017) (7)
- Erratum: Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci (American Journal of Human Genetics (2012) 90 (410-425)) (2012) (6)
- Molecular scanning of the beta‐3‐adrenergic receptor gene in Pima Indians and Caucasians (1999) (6)
- TCF 7 L 2 Polymorphism , Weight Loss and Proinsulin : Insulin Ratio in the Diabetes Prevention Program (2011) (6)
- KCNQ1 and Long QT Syndrome in 1/45 Amish (2020) (6)
- Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen (2021) (6)
- Increased Gut Microbiome Diversity Following a High Fiber Mediterranean Style Diet (2013) (6)
- Transgenic animals. (1996) (6)
- A case of congenital generalized lipodystrophy: metabolic effects of four dietary regimens. Lack of association of CGL with polymorphism in the lamin A/C Gene (2001) (6)
- Profiling copy number variation and disease associations from 50,726 DiscovEHR Study exomes (2017) (6)
- When phenotype does not match genotype: importance of “real-time” refining of phenotypic information for exome data interpretation (2020) (6)
- Association of the Vitamin D Metabolism Gene CYP 24 A 1 With Coronary Artery Calcification (2010) (5)
- A common variant in fibroblast growth factor binding protein 1 (FGFBP1) is associated with bone mineral density and influences gene expression in vitro. (2010) (5)
- Genetic and functional evidence relates a missense variant in B4GALT1 to lower LDL-C and fibrinogen (2019) (5)
- THE INFLUENCE OF CYTOCHROME P450 2C19*2 AND*17 GENOTYPE, DIPLOTYPE AND METABOLIZER STATUS ON PLATELET REACTIVITY IN PATIENTS ON MAINTENANCE CLOPIDOGREL THERAPY (2010) (5)
- Epilepsy and electroencephalogram evolution in YWHAG gene mutation: A new phenotype and review of the literature (2021) (5)
- The mechanism of interaction of dislocations with point defects in ionic crystals (2002) (5)
- No effect of Trp64Arg beta3-adrenoceptor polymorphism on the plasma leptin concentration in Pima Indians. (1998) (5)
- RNA Template-Specific Polymerase Chain Reaction (RS-PCR) : A Modification of RNA-PCR that Dramatically Reduces the Frequency of False Positives. (1993) (5)
- Clonal hematopoiesis is driven by aberrant activation of TCL1A (2021) (5)
- The Effect of Interventions to Prevent Type 2 Diabetes on the Development of Diabetic Retinopathy: The DPP/DPPOS Experience (2022) (5)
- Sunday, 26 August 2012 (2012) (5)
- Serum alanine aminotransferase is correlated with hematocrit in healthy human subjects (2012) (5)
- Heterozygosity for a Pathogenic Variant in SLC12A3 That Causes Autosomal Recessive Gitelman Syndrome Is Associated with Lower Serum Potassium. (2021) (4)
- The free energy of vacancy pairs (1978) (4)
- An Amish founder population reveals rare-population genetic determinants of the human lipidome (2022) (4)
- Exome sequencing and characterization of 49,960 individuals in the UK Biobank (2020) (4)
- Model for Integration of Monogenic Diabetes Diagnosis Into Routine Care: The Personalized Diabetes Medicine Program. (2022) (4)
- Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes (2022) (4)
- Genome‐wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals (2021) (4)
- CYP 2 C 19 Metabolizer Status and Clopidogrel Ef fi cacy in the Secondary Prevention of Small Subcortical Strokes ( SPS 3 ) Study (2015) (4)
- Preparation of RNA from lyophilized tissue: a stable and reliable method for long-term storage. (1994) (4)
- Molecular scanning of beta-3-adrenergic receptor gene in total congenital lipoatrophic diabetes mellitus. (1997) (4)
- Self-Reported Sleep Duration and Pattern in Old Order Amish and Non-Amish Adults. (2019) (4)
- Rapid synthesis of standards for allele-specific oligonucleotide hybridization. (1994) (4)
- Exome Sequencing of 21 Bardet‐Biedl Syndrome (BBS) Genes to Identify Obesity Variants in 6,851 American Indians (2021) (3)
- Multiple dimensions of stress vs. genetic effects on depression (2021) (3)
- Supplementary Material 6 (2014) (3)
- Recovery of plasmid DNA from nonviable bacterial colonies and cultures. (1992) (3)
- Supplementary Material 3 (2015) (3)
- Heritability of plasma neopterin levels in the Old Order Amish (2017) (3)
- The worry about clopidogrel "nonresponsiveness": identification and treatment in the post-percutaneous coronary intervention patient. (2009) (3)
- Exome sequencing identifies a nonsense variant in DAO associated with reduced energy expenditure in American Indians. (2020) (3)
- Supplementary Material 7 (2014) (3)
- Thrombotic Risk Determined by STAB 2 Variants in a Population-Based Cohort Study. (2021) (3)
- Biallelic truncating variants in the muscular A‐type lamin‐interacting protein (MLIP) gene cause myopathy with hyperCKemia (2021) (3)
- CYP2C19 and Clopidogrel Response: More Than Validation in the Real World (2012) (3)
- Adiponectin levels and genotype (2008) (3)
- Supplementary Material 5 (2014) (3)
- Genetic Factors in Exceptional Longevity—Reply (2004) (3)
- Body Image and Life Satisfaction in Amish, Catholic, and Non-Religious Women (2018) (3)
- The role of phenotype-based search approaches using public online databases in diagnostics of Mendelian disorders (2021) (3)
- The diagnostic efficacy of exome data analysis using fixed neurodevelopmental gene lists: Implications for prenatal setting (2021) (3)
- The 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) score and diabetes risk in the Diabetes Prevention Program Outcomes Study (DPPOS) (2022) (3)
- Genome-wide association study of kidney function decline in individuals of European descent: the CKDGen Consortium. (2015) (3)
- Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program (2021) (3)
- Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity (2020) (3)
- Role of a Proline Insertion in the Insulin Promoter Factor 1 (IPF1) Gene in African Americans With Type 2 Diabetes (2006) (3)
- Calcified Granulomatous Disease: Occupational Associations and Lack of Familial Aggregation (2014) (2)
- The two nonallelic Xenopus insulin genes are expressed coordinately in the adult pancreas. (1994) (2)
- Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish. (2005) (2)
- Clinical and genetic validity of quantitative bipolarity (2019) (2)
- Two intronic cis‐acting variants in both alleles of the POLR3A gene cause progressive spastic ataxia with hypodontia (2021) (2)
- Abstract 16563: Genetic and Pharmacological Inactivation of ANGPTL3 is Associated With Reduced Atherosclerotic Cardiovascular Disease (2016) (2)
- Assessment of the potential role of natural selection in type 2 diabetes and related traits across human continental ancestry groups: comparison of phenotypic with genotypic divergence (2020) (2)
- Rapid (ligase-free) subcloning of PCR products. (1997) (2)
- The prevalence of prenatal sonographic findings in postnatal diagnostic exome sequencing performed for neurocognitive phenotypes: A cohort study (2022) (2)
- Clonal Hematopoiesis Analyses in Clinical, Epidemiologic, and Genetic Aging Studies to Unravel Underlying Mechanisms of Age-Related Dysfunction in Humans (2022) (2)
- 914. Toxoplasma Gondii Serointensity and Seropositivity and Their Heritability and Household-Related Associations in the Old Order Amish (2017) (2)
- Mapping Genes in Isolated Populations: Lessons from the Old Order Amish (2015) (2)
- Insulin, but Not Insulin‐like Growth Factor‐I, Is Expressed during Early Nervous System Development in Prepancreatic Xenopus Embryos (1993) (2)
- Genetic versus stress and mood determinants of sleep in the Amish (2021) (2)
- Self-Reported Sleep Duration and Pattern in Old Order Amish and Non-Amish Adults. (2019) (2)
- N-cyclo-[Leu5]enkephalin: a rational approach for the synthesis of conformationally restricted cyclic pentapeptides. (1985) (2)
- 297. Dichgans M, Malik R, Konig IR, Rosand J, Clarke R, Gretarsdottir S, . . . , Schunkert H (2014). Shared genetic susceptibility to ischemic stroke and coronary artery disease: a (2014) (2)
- Genome-wide association scans identify novel loci that influence lipid levels and risk of coronary artery disease (2007) (2)
- Genetics of the metabolic complications of obesity. (2010) (2)
- Preparation and properties of poly(2,2-dialkyltrimethylene sulphones) (1981) (2)
- Does bariatric surgery reduce obesity-related comorbidities? (2005) (1)
- UGT1A1 genetic variants are associated with increases in bilirubin levels in rheumatoid arthritis patients treated with sarilumab (2017) (1)
- Cognitive profiles and heritability estimates in the Old Order Amish (2016) (1)
- Supplementary Material 9 (2013) (1)
- Putative association signals identified through high-density LD mapping of the replicated T2D linkage region on chromosome 1q are not confirmed in large-scale follow-up studies (2008) (1)
- Genome-wide physical activity interactions in adiposity (2017) (1)
- Clinical case study meets population cohort: Identification of a BRCA1 pathogenic founder variant in Orcadians (2022) (1)
- Discovery and Refinement Supplementary (2015) (1)
- Carbohydrate Metabolism: Diabetes Mellitus, Genomic Aberrations (2004) (1)
- NFAT 5 and SLC 4 A 10 Loci Associate with Plasma Osmolality (2017) (1)
- The burden of pathogenic variants in clinically actionable genes in a founder population (2021) (1)
- Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians (2022) (1)
- Supplementary Material 4 (2015) (1)
- Rapid (ligase-free) subcloning of polymerase chain reaction products. (1993) (1)
- 556. Adiponectin Gene Polymorphism and Seasonality in the Old Order Amish (2017) (1)
- Depression, stress and regional cerebral blood flow (2023) (1)
- Genome-wide survey of parent-of-origin specific associations across clinical traits derived from electronic health records (2020) (1)
- Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population (2022) (1)
- High-density association mapping and comprehensive tagging of the type 2 diabetes linkage region on chromosome 1q in 4 European populations (2007) (1)
- Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial (2022) (1)
- Clinical characterization of familial hypercholesterolemia due to an amish founder mutation in Apolipoprotein B (2022) (1)
- Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn’s Disease (2021) (1)
- Sex-specific effects of serum sulfate level and SLC13A1 nonsense variants on DHEA homeostasis (2017) (1)
- Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish (2018) (1)
- Loci influencing blood pressure identified using a cardiovascular gene-centric array (Correction to Ganesh et al. 22 (8): 1663) (2013) (1)
- Supplementary Material 15 (2013) (1)
- OBESITY AND DIABETES : RESEARCH POINTS TO GENETIC CONNECTION (1997) (1)
- 203. Environmental Risk Factors for Toxoplasma Gondii Seropositivity in the Old Order Amish (2017) (1)
- Genetics of Type 2 Diabetes: From Candidate Genes to Genome-Wide Association Analysis (2010) (1)
- Historical Overview of Gene Discovery Methodologies in Type 2 Diabetes (2016) (1)
- A novel TUFM homozygous variant in a child with mitochondrial cardiomyopathy expands the phenotype of combined oxidative phosphorylation deficiency 4 (2019) (1)
- Variants in ANGPTL4 and the Risk of Coronary Artery Disease. (2016) (1)
- Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids (2021) (1)
- A novel mutation in MYCN gene causing congenital absence of the flexor pollicis longus tendon as an unusual presentation of Feingold syndrome 1. (2020) (1)
- Erratum: Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height ((The American Journal of Human Genetics (2010) 88 (6-18)) (2012) (1)
- A missense variant Arg611Cys in LIPE which encodes hormone sensitive lipase decreases lipolysis and increases risk of type 2 diabetes in American Indians (2021) (1)
- Cerebral blood flow and cardiovascular risk effects on resting brain regional homogeneity (2022) (1)
- Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (2021) (1)
- ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma (2022) (1)
- Autoantibodies in Type 1 and Type 2 diabetes in the Old Order Amish of Lancaster County, Pennsylvania (2003) (1)
- Author Correction: A population-specific reference panel empowers genetic studies of Anabaptist populations (2018) (0)
- Abstract 11242: Clopidogrel Improves Endothelial Function in Healthy Individuals With Heightened Platelet Aggregation (2016) (0)
- Genome-wide association analysis of common genetic variants of resistant hypertension (2018) (0)
- Comprehensive Genetic Analysis of Druze Provides Insights into Carrier Screening (2023) (0)
- Impact of parental relatedness on reproductive outcomes among the Old Order Amish of Lancaster County (2022) (0)
- KCNJ11 Mutation in One Family is Associated with Adult-Onset Rather than Neonatal-Onset Diabetes Mellitus (2018) (0)
- University of Groningen A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function Porcu, (2013) (0)
- Abstract P392: Exome Sequencing From Extreme Responders to Aspirin Identifies a Novel Variant Associated With Platelet Aggregation (2015) (0)
- Administration: Real Life Is Complicated Responding to the Clopidogrel Warning by the US Food and Drug (2011) (0)
- Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis (2020) (0)
- Old Order Amish Have Higher Than Expected Severity of Coronary Artery Calcification (2005) (0)
- Decision letter: Whole-genome sequencing analysis of semi-supercentenarians (2020) (0)
- When phenotype does not match genotype: importance of “real-time” refining of phenotypic information for exome data interpretation (2020) (0)
- The Old Order Amish: A unique model to study ageing (2000) (0)
- Linkage disequilibrium mapping of the type 2 diabetes susceptibility variants on chromosome Iq in European populations (2005) (0)
- Parkinson’s Disease-Related Motor and Nonmotor Symptoms in the Lancaster Amish (2020) (0)
- Abstract 3753: Is Isolated Low HDL-C An Atherogenic Phenotype? The Amish Family Calcification Study (2007) (0)
- Regionally enriched rare deleterious exonic variants in the UK and Ireland (2022) (0)
- Genetic Determinants of Arterial Thrombosis (2009) (0)
- O B S E Rvat I O N S Table 1—characteristics of Respondents Aged 45 Years Reporting Screening for Diabetes in Montana in 1998 (0)
- POSTER SESSION II (2015) (0)
- Trp64Arg Beta-3-Adrenergic Receptor A Common Genetic Variant that Influences Features of the Insulin Resistance Syndrome (Syndrome X) and the Age of Onset of Noninsulin Dependent Diabetes Mellitus (1996) (0)
- Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof (2018) (0)
- Functional characterization of blood pressure‐associated common variants in STK39 (2009) (0)
- Obesity and diabetes: research points to genetic connection. Interview by Mark E. Weksler. (1997) (0)
- Next generation sequencing for HLA loci in full heritage Pima Indians of Arizona, Part II: HLA-A, -B, and -C with selected non-classical loci at 4-field resolution from whole genome sequences. (2021) (0)
- Functional modeling of human lysosomal acid alpha-glucosidase variants (2022) (0)
- Front & Back Matter (2013) (0)
- Abstract 32: Analysis of Serum Clopidogrel Active Metabolite Concentration Identifies Novel Genetic Variants Associated With Clopidogrel Pharmacokinetics (2016) (0)
- Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish (2023) (0)
- Large-scale follow-up study does not confirm putative association signals in the NOS1AP and PKLR gene regions on chromosome 1q with type 2 diabetes (2008) (0)
- Evidence of Neurovascular Water Exchange and Endothelial Vascular Dysfunction in Schizophrenia: An Exploratory Study. (2023) (0)
- 78. NEURODEVELOPMENTAL CONSEQUENCES OF RARE SETD1A MISSENSE VARIANTS ASSOCIATED WITH RISK FOR BIPOLAR DISORDER (2022) (0)
- Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response (2014) (0)
- Xenopus Zuevis Contains Two Nonallelic Preproinsulin Genes cDNA (2001) (0)
- Genome-wide association and functional follow-up reveals new loci for kidney function | NOVA. The University of Newcastle's Digital Repository (2012) (0)
- The β3-Adrenergic Receptor and Susceptibility to Obesity, the Insulin Resistance Syndrome, and Noninsulin-Dependent Diabetes Mellitus (1998) (0)
- VARIANTS OF PCSK 9 ARE ASSOCIATED WITH TRIGLYCERIDE LEVELS IN THE OLD ORDER AMISH Student Researcher : (2007) (0)
- Lack of Cardiovascular Disease Among Old Order Amish With Familial Defective Apolipoprotein B—Reply (2011) (0)
- 1977-P: Whole-Exome Sequencing Followed by Functional Analysis to Identify Variants That May Influence Body Mass Index (BMI) via a Role in Adipogenesis (2020) (0)
- B4galt1 variants and uses thereof (2018) (0)
- S60GENOME SEQUENCING IN A FOUNDER POPULATION IDENTIFIES POPULATION-ENRICHED PROTEIN-CODING VARIANTS IN NEURODEVELOPMENTAL GENES ASSOCIATED WITH RISK FOR MOOD DISORDERS (2019) (0)
- Pharmacogenomics: the low-hanging fruit in the personalized medicine tree (2022) (0)
- Functional Variants in MBL2 are Associated with Type 2 diabetes and Pre- diabetic Traits in Pima Indians and the Old Order Amish Running Title: MBL2 and Type 2 diabetes (2010) (0)
- Tobacco Use And Airway Obstruction In The Old Order Amish (2012) (0)
- Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel (2011) (0)
- Genome Scans of Type 2 Diabetes Mellitus (2003) (0)
- A population-specific reference panel empowers genetic studies of Anabaptist populations (2017) (0)
- Abstract 15465: Precision Medicine Approach to Resistant Hypertension: Genetic Markers of Resistant Hypertension Through a Genome-wide Association Study (GWAS) in the Secondary Prevention of Subcortical Strokes (SPS3) (2015) (0)
- Impact of genetic relatedness of parents on reproductive outcomes (2021) (0)
- Genome-wide survey of parent-of-origin-specific associations across clinical traits derived from electronic health records (2021) (0)
- SAT0179 The ASP358ALA variant in the IL6R gene is significantly associated with differences in soluble IL-6R protein levels but not with differences in sarilumab response in rheumatoid arthritis (RA) patients (2017) (0)
- American Society for Clinical Pharmacology and Therapeutics (1975) (0)
- Rare coding variants in CHRNB2 reduce the likelihood of smoking (2022) (0)
- COLLECTIVE EFFECTS OF ADRENERGIC RECEPTOR (AR) POLYMORPHISMS ARE ASSOCIATED WITH BODY FAT RESPONSE TO TRAINING (2003) (0)
- Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings (2021) (0)
- 238-LB: Prevalence of GCK-MODY in 92,412 Exomes from an Unselected Clinical Population (2019) (0)
- 2116-P: A Pipeline to Explore Rare Variation Which Can Contribute to Extreme Obesity in American Indians (2019) (0)
- Replicated association between type 2 diabetes and variants in CAPON revealed by high density linkage disequilibrium mapping on chromosome 1q (2006) (0)
- Vitamin and Supplement Use in the Old Order Amish: Gender-specific prevalence and associations with use (2015) (0)
- 271-OR: Whole-Exome Sequence Identifies Potentially Functional Rare Variants in Bardet-Biedl Syndrome (BBS) Genes that Associate with Obesity in American Indians (2019) (0)
- Running Title : Candidate genes in the Diabetes Prevention Program (2010) (0)
- Genetic Predictors ofWeight Loss and Weight Regain After Intensive Lifestyle Modi fi cation , Metformin Treatment , or Standard Care in the Diabetes Prevention Program (2011) (0)
- Author Correction: A population-specific reference panel empowers genetic studies of Anabaptist populations (2018) (0)
- Determination of the genomic structures of two nonallelic preproinsulin genes in Xenopus laevis using the polymerase chain reaction. (1995) (0)
- Epigenetic Signature of Impaired Fasting Glucose in the Old Order Amish. (2017) (0)
- The C297T Polymorphism In Uncoupling Protein 3 Does Not Associate With Traits Related To Obesity (1998) (0)
- FABP2 Genotype and Exercise Training as Determinants of Glucoregulatory Function and Postprandial Lipemia (2004) (0)
- 503. Neurodevelopmental Consequences of Rare SETD1A Missense Variants Associated With Risk for Bipolar Disorder (2023) (0)
- GWAS results in the Diabetes Prevention Program EXTENSION OF TYPE 2 DIABETES GENOME-WIDE ASSOCIATION SCAN RESULTS IN THE DIABETES PREVENTION PROGRAM (2008) (0)
- Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure (2020) (0)
- Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes (2023) (0)
- Abstract 15853: Identification of Several Novel Loci for Coagulation and Fibrinolysis (2017) (0)
- Pharmacogenetics of SGLT2 Inhibitors: Validation of a sex-agnostic pharmacodynamic biomarker (2023) (0)
- EFFECTS OF PPAR-GAMMA GENOTYPE ON ENDURANCE TRAINING-INDUCED CHANGES IN INSULIN RESPONSE TO ORAL GLUCOSE (2003) (0)
- Contents Vol. 9, 2016 (2017) (0)
- Supplementary Material for: The CAPN2/CAPN8 Locus on Chromosome 1q Is Associated with Variation in Serum Alpha-Carotene Concentrations (2016) (0)
- Nitrate From Drinking Water and Prevalence of Abnormal Thyroid Conditions Among the Old Order Amish in Pennsylvania (2011) (0)
- Contents Vol. 64, 2007 (2007) (0)
- intensities in postmenopausal women Cardiovascular hemodynamics with increasing exercise (2015) (0)
- Large-scale association studies to identify diabetes-susceptibility loci on chromosome 1q: The importance of stringent quality control (2006) (0)
- Exome sequencing reveals aggregates of rare variants in glycosyltransferase and other genes influencing immunoglobulin G and transferrin glycosylation (2022) (0)
- Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish (2018) (0)
- Abstract 14753: Loss of Function ABCC8 Mutations Are Associated With Pulmonary Arterial Hypertension (2017) (0)
- Exome-wide association studies in general and long-lived populations identify genetic variants related to human age (2020) (0)
- Genome-wide physical activity interactions in adiposity A meta-analysis of 200,452 adults Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults (2017) (0)
- Genome-wide association study reveals loci with sex-specific effects on plasma bile acids (2022) (0)
- Genetic factors in exceptional longevity. Authors' reply (2004) (0)
- Corrigendum to ‘An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs’ [J Hepatol 2021;75(3):572–581] (2021) (0)
- 294. Positive Association between Toxoplasma Gondii IgG Serointensity and Depression in the Old Order Amish (2017) (0)
- Abstract 37: Secondary Stroke Prevention With Aspirin and Clopidogrel in CYP2C19 *17 Carriers Increases Risk of Major Non-CNS Bleeding (2019) (0)
- Parkinson’s disease-related motor and non-motor symptoms are not more prevalent in the Lancaster Amish (2020) (0)
- Electron emission and luminescence due to plastic deformation of ionic crystals (1998) (0)
- Abstract 1438: Myocardial Infarction Associated SNPs on Chromosome 9p21.3 are Associated with Coronary Artery Calcification but Not Carotid Intimal Medial Thickness in the Amish (2008) (0)
- Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis (2023) (0)
- Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver diseases that have distinct effects on metabolic traits Speliotes (0)
- The genetic determinants of recurrent somatic mutations in 43,693 blood genomes (2023) (0)
- Academic and industry perspectives on pharmacogenomics: drug optimization (2019) (0)
- Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes (2018) (0)
- Chronotype is associated with seasonal weight and sleep duration changes in the old order Amish (2015) (0)
- Abstract 15641: Genome-Wide Association Study and Meta-Analysis of Aspirin Responsiveness in Individuals of European Descent (2011) (0)
- Follow-Up in Myocardial Infarction Genome-Wide Association Study for Coronary Artery Calcification With (2011) (0)
- Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction (2020) (0)
- Variation in the retinoid X receptor gamma gene is associated with type 2 diabetes in sample sets displaying linkage to chromosome 1q (2006) (0)
- A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant (2019) (0)
- Acute pharmacodynamic responses to exenatide: Drug-induced increases in insulin secretion and glucose effectiveness (2023) (0)
- The Thrifty Microbiome: The Role of the Gut Microbiota in Obesity in the Amish (2010) (0)
- Abstract P365: A Variant Impacting Beta-Oxidation of Medium-Chain Fatty Acids is Associated With Response to Triglyceride Challenge and Lipoprotein Subfractions (2015) (0)
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