Alastair Buchan

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Alastair Buchan is affiliated with the following schools: University of Cambridge, University of Western Ontario, University of Calgary, University of Oxford, University of Ottawa, Cornell University

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Why Is Alastair Buchan Influential?

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According to Wikipedia, Alastair Buchan is a British neurologist and researcher in stroke medicine. His main research interest is how to make neuroprotection a reality in the clinic. From October 2008 until January 2017, he served as the Dean of Medicine and the Head of the Medical Sciences Division, University of Oxford. He currently holds the Chair of Stroke Research and is the Pro-Vice-Chancellor and Head of Brexit Strategy at the University of Oxford.

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Alastair Buchan's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
Glial and neuronal control of brain blood flow (2010) (2001)
Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy (2000) (1915)
Capillary pericytes regulate cerebral blood flow in health and disease (2014) (1329)
*North American Symptomatic Carotid Endarterectomy Trial (NASCET) Steering Committee. Beneficial Effect of Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis. (1991) (951)
Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score. (2000) (935)
Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke. (2001) (772)
Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia (1990) (590)
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial (2007) (497)
Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain (1993) (493)
Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study (2005) (457)
Serum glucose level and diabetes predict tissue plasminogen activator-related intracerebral hemorrhage in acute ischemic stroke. (1999) (366)
Imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion-weighted imaging (2005) (340)
Complications of intracerebral haemorrhage (2012) (328)
A randomized study of the influence of perfusion technique and pH management strategy in 316 patients undergoing coronary artery bypass surgery. II. Neurologic and cognitive outcomes. (1995) (326)
Mechanisms of Hemorrhagic Transformation After Tissue Plasminogen Activator Reperfusion Therapy for Ischemic Stroke (2004) (292)
Selection of Acute Ischemic Stroke Patients for Intra-Arterial Thrombolysis With Pro-Urokinase by Using ASPECTS (2003) (272)
Transplantation of cultured human neuronal cells for patients with stroke (2001) (262)
The four-vessel occlusion rat model: method for complete occlusion of vertebral arteries and control of collateral circulation. (1988) (259)
Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats (1991) (255)
Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility. (2001) (250)
Neuroprotection for Ischaemic Stroke: Translation from the Bench to the Bedside (2012) (246)
The Neurotoxicity of Tissue Plasminogen Activator? (2004) (243)
Early risk of stroke after a transient ischemic attack in patients with internal carotid artery disease (2004) (241)
Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imaging (2005) (239)
The N-methyl-D-aspartate antagonist, MK-801, fails to protect against neuronal damage caused by transient, severe forebrain ischemia in adult rats (1991) (231)
A New Model of Temporary Focal Neocortical Ischemia in the Rat (1992) (228)
*North American Symptomatic Carotid Endarterectomy Trial (NASCET) Steering Committee. North American Symptomatic Carotid Endarterectomy Trial Methods, Patients Characteristics and Progress. (1991) (227)
Biphasic Opening of the Blood-Brain Barrier Following Transient Focal Ischemia: Effects of Hypothermia (1999) (226)
Prolonged but Delayed Postischemic Hypothermia: A Long-term Outcome Study in the Rat Middle Cerebral Artery Occlusion Model (2000) (220)
Indefatigable CA1 Sector Neuroprotection with Mild Hypothermia Induced 6 Hours after Severe Forebrain Ischemia in Rats (1999) (214)
Why are stroke patients excluded from TPA therapy? (2001) (212)
Why do women choose or reject careers in academic medicine? A narrative review of empirical evidence (2016) (210)
Imaging of acute stroke (2006) (210)
Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy (2013) (200)
DNA damage consistent with apoptosis in transient focal ischaemic neocortex. (1994) (198)
IMS II Trial Investigators. The Interventional Management of Stroke (IMS) II Study. (2007) (194)
Neurological complications of acute ischaemic stroke (2011) (190)
Statins Are Associated With Better Outcomes After Carotid Endarterectomy in Symptomatic Patients (2005) (189)
Immediate or delayed mild hypothermia prevents focal cerebral infarction (1992) (187)
The rise and fall of NMDA antagonists for ischemic stroke. (2004) (183)
Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of stroke (2003) (181)
ASPECTS on CTA Source Images Versus Unenhanced CT: Added Value in Predicting Final Infarct Extent and Clinical Outcome (2004) (181)
Delayed Treatment with AMPA, but Not NMDA, Antagonists Reduces Neocortical Infarction (1994) (180)
A randomized study of the influence of perfusion technique and pH management strategy in 316 patients undergoing coronary artery bypass surgery. I. Mortality and cardiovascular morbidity. (1995) (179)
Admission Hyperglycemia Predicts a Worse Outcome in Stroke Patients Treated With Intravenous Thrombolysis (2008) (179)
Thrombolysis in patients older than 80 years with acute ischaemic stroke: Canadian Alteplase for Stroke Effectiveness Study (2006) (177)
Continuing postischemic neuronal death in CA1: influence of ischemia duration and cytoprotective doses of NBQX and SNX-111 in rats. (1999) (174)
Neuroprotection for Stroke: Current Status and Future Perspectives (2012) (172)
Recent advances in management of transient ischaemic attacks and minor ischaemic strokes (2006) (170)
Complications of endovascular treatment for acute ischemic stroke: Prevention and management (2017) (168)
Asymptomatic Hemorrhage After Thrombolysis May Not Be Benign: Prognosis by Hemorrhage Type in the Canadian Alteplase for Stroke Effectiveness Study Registry (2007) (164)
Hyperdense Sylvian Fissure MCA “Dot” Sign: A CT Marker of Acute Ischemia (2001) (152)
Treatment with an AMPA Antagonist 12 Hours following Severe Normothermic Forebrain Ischemia Prevents CA1 Neuronal Injury (1993) (149)
Apoptosis after experimental stroke: fact or fashion? (2000) (148)
Effectiveness of t-PA in acute ischemic stroke (2000) (147)
Neuroprotection in stroke: the importance of collaboration and reproducibility (2017) (146)
The effect of the NMDA receptor antagonist MK-801 on cerebral blood flow and infarct volume in experimental focal stroke (1992) (143)
A Selective N-Type Ca2+-Channel Blocker Prevents CA1 Injury 24 h following Severe Forebrain Ischemia and Reduces Infarction following Focal Ischemia (1994) (142)
Caspase inhibitors reduce neuronal injury after focal but not global cerebral ischemia in rats. (2000) (141)
Tirilazad Reduces Cortical Infarction After Transient but Not Permanent Focal Cerebral Ischemia in Rats (1992) (141)
Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia. (1991) (140)
Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted? (1990) (138)
Stroke: Working Toward a Prioritized World Agenda (2010) (136)
Leukoaraiosis and intracerebral hemorrhage after thrombolysis in acute stroke (2007) (133)
Structural and functional restoration by collateral sprouting of hippocampal 5-HT axons (1978) (131)
Biology of ischemic cerebral cell death. (1999) (127)
e-ASPECTS software is non-inferior to neuroradiologists in applying the ASPECT score to computed tomography scans of acute ischemic stroke patients (2017) (125)
An Improved Scoring System for Identifying Patients at High Early Risk of Stroke and Functional Impairment after an Acute Transient Ischemic Attack or Minor Stroke (2008) (125)
Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia (2003) (115)
Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke. (2000) (114)
Effects of NXY‐059 in experimental stroke: an individual animal meta‐analysis (2009) (109)
Closing the gender leadership gap: a multi-centre cross-country comparison of women in management and leadership in academic health centres in the European Union (2017) (107)
Ischemic stroke in the elderly: an overview of evidence (2010) (106)
Reliability of Assessing Percentage of Diffusion-Perfusion Mismatch (2003) (102)
Differences in DNA Fragmentation following Transient Cerebral or Decapitation Ischemia in Rats (1995) (101)
Lost in translation: taking neuroprotection from animal models to clinical trials (2004) (101)
Intraluminal thrombus in the cerebral circulation. Implications for surgical management. (1988) (100)
Stroke Therapy Academic Industry Roundtable. Recommendations for clinical trial evaluation of acute stroke therapies. (2001) (99)
Neuroprotection by Dimethyloxalylglycine following Permanent and Transient Focal Cerebral Ischemia in Rats (2011) (96)
NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat (2001) (94)
Diabetes, leukoencephalopathy and rage (2006) (94)
A systematic review and meta‐analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke (2015) (94)
A global call for action to include gender in research impact assessment (2016) (93)
AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists? (1993) (92)
Thrombolysis at 3–4.5 Hours after Acute Ischemic Stroke Onset – Evidence from the Canadian Alteplase for Stroke Effectiveness Study (CASES) Registry (2010) (90)
Acute Intravenous–Intra-Arterial Revascularization Therapy for Severe Ischemic Stroke (2002) (86)
MR molecular imaging of early endothelial activation in focal ischemia (2004) (86)
Interobserver Variation of ASPECTS in Real Time (2004) (85)
Therapeutic manipulation of the HIF hydroxylases. (2010) (84)
Abciximab Emergent Stroke Treatment Trial (AbESTT) Investigators. Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of a randomized phase 2 trial (2005) (83)
Sex-Based Differences in the Effect of Intra-Arterial Treatment of Stroke: Analysis of the PROACT-2 Study (2006) (83)
Temperature-Regulated Model of Focal Ischemia in the Mouse: A Study With Histopathological and Behavioral Outcomes (2004) (82)
Leukoaraiosis, intracerebral hemorrhage, and functional outcome after acute stroke thrombolysis (2017) (82)
The exact science of stroke thrombolysis and the quiet art of patient selection. (2013) (80)
Building a "brain attack" team to administer thrombolytic therapy for acute ischemic stroke. (2000) (77)
Is intravenous recombinant tissue plasminogen activator (rt-PA) safe for use in patients over 80 years old with acute ischaemic stroke? - The Calgary experience. (2004) (74)
Molecular Magnetic Resonance Imaging of Acute Vascular Cell Adhesion Molecule-1 Expression in a Mouse Model of Cerebral Ischemia (2010) (73)
Septal elicitation of hippocampal theta rhythm after localized de-afferentation of serotoninergic fibers (1980) (72)
Dehydroepiandrosterone (DHEA) reduces neuronal injury in a rat model of global cerebral ischemia (2001) (70)
Serotonin transporter gene promoter region polymorphism associated with poststroke major depression. (2006) (70)
Assessing research impact in academic clinical medicine: a study using Research Excellence Framework pilot impact indicators (2012) (67)
Antagonism of the NMDA and non-NMDA receptors in global versus focal brain ischemia. (1993) (67)
The gender effect in stroke thrombolysis (2008) (61)
Septo-hippocampal deafferentation protects CA1 neurons against ischemic injury (1990) (60)
Outcomes of Thrombolysis for Acute Ischemic Stroke in Octogenarians Versus Nonagenarians (2010) (58)
Early T1- and T2-weighted MRI signatures of transient and permanent middle cerebral artery occlusion in a murine stroke model studied at 9.4T (2005) (57)
Physicians' perceptions of the benefits and risks of warfarin for patients with nonvalvular atrial fibrillation. (2001) (57)
A Critical Role for Astrocytes in Hypercapnic Vasodilation in Brain (2017) (57)
Canadian Guidelines for Intravenous Thrombolytic Treatment in Acute Stroke: A Consensus Statement of The Canadian Stroke Consortium (1998) (55)
The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke (2015) (55)
How well does ASPECTS predict the outcome of acute stroke treated with IV tPA? (2006) (55)
Cellular and molecular determinants of stroke-induced changes in subventricular zone cell migration. (2011) (54)
Importance of preclinical research in the development of neuroprotective strategies for ischemic stroke. (2014) (54)
An Early Loss in Membrane Protein Kinase C Activity Precedes the Excitatory Amino Acid‐Induced Death of Primary Cortical Neurons (1996) (54)
MR Angiography Compared to Conventional Selective Angiography in Acute Stroke (2006) (53)
Improved regional cerebral blood flow is important for the protection seen in a mouse model of late phase ischemic preconditioning (2006) (53)
Cerebral blood flow alteration in neuroprotection following cerebral ischaemia (2011) (50)
The relative importance of barriers to the prescription of warfarin for nonvalvular atrial fibrillation. (2003) (49)
Identification of calcium channels involved in neuronal injury in rat hippocampal slices subjected to oxygen and glucose deprivation (1997) (49)
Tissue plasminogen activator does not increase neuronal damage in rat models of global and focal ischemia (1999) (49)
Brain derived neurotrophic factor induction of N-methyl-D-aspartate receptor subunit NR2A expression in cultured rat cortical neurons (1998) (49)
Mechanisms of cerebral ischemia: intracellular cascades and therapeutic interventions. (1996) (49)
NMDA antagonists: their role in neuroprotection. (1997) (48)
Advances in cerebral ischemia: experimental approaches. (1992) (47)
NERVE GROWTH-FACTOR - PRETREATMENT AMELIORATES ISCHEMIC HIPPOCAMPAL NEURONAL INJURY (1990) (47)
Neuroprotection achieved with a novel proteasome inhibitor which blocks NF‐κB activation (2000) (47)
Organizational Culture in an Academic Health Center: An Exploratory Study Using a Competing Values Framework (2012) (46)
Complications associated with recombinant tissue plasminogen activator therapy for acute ischaemic stroke. (2013) (46)
Inflammatory Stroke Extracellular Vesicles Induce Macrophage Activation (2017) (45)
Stroke: Working toward a Prioritized World Agenda (2010) (45)
Kir6.2-containing ATP-sensitive potassium channels protect cortical neurons from ischemic/anoxic injury in vitro and in vivo (2007) (44)
Increases in DNA lesions and the DNA damage indicator Gadd45 following transient cerebral ischemia. (1997) (44)
A study of the workload and effectiveness of a comprehensive acute stroke service (2005) (43)
Intraluminal thrombus of the internal carotid arteries: angiographic demonstration of resolution with anticoagulant therapy alone. (1986) (42)
Therapeutic hypothermia in experimental models of focal and global cerebral ischemia and intracerebral hemorrhage (2008) (42)
North American Symptomatic Carotid Endarterectomy Trial (NASCET) Steering Committee. The Benefit of Carotid Endarterectomy in Symptomatic Patients with Moderate and Severe Stenosis. (1998) (42)
Failure to prevent selective CA1 neuronal death and reduce cortical infarction following cerebral ischemia with inhibition of nitric oxide synthase (1994) (42)
Stroke: Working toward a Prioritized World Agenda (2010) (42)
Ependymal ciliary dysfunction and reactive astrocytosis in a reorganized subventricular zone after stroke. (2013) (41)
Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation (2017) (40)
Methodology for the Canadian Activase for Stroke Effectiveness Study (CASES) (2001) (40)
Biochemistry of ischemic stroke. (2003) (40)
The Erythropoietin NeuroProtective Effect: Assessment in CABG Surgery (TENPEAKS): A Randomized, Double-Blind, Placebo Controlled, Proof-of-Concept Clinical Trial (2009) (40)
Understanding and managing ischemic stroke. (2001) (39)
The Contribution of L-Arginine to the Neurotoxicity of Recombinant Tissue Plasminogen Activator following Cerebral Ischemia: A Review of rtPA Neurotoxicity (2010) (39)
HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice (2014) (39)
Microarray analysis of the global gene expression profile following hypothermia and transient focal cerebral ischemia (2012) (39)
Roles of individual prolyl‐4‐hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice (2012) (38)
Multicentre prospective cohort study of body mass index and postoperative complications following gastrointestinal surgery (2016) (38)
Intra-arterial Thrombolysis for Retinal Artery Occlusion: The Calgary Experience (2005) (37)
Top Priorities for Cerebroprotective Studies: A Paradigm Shift. (2021) (35)
Do NMDA antagonists prevent neuronal injury? No. (1992) (35)
Novel method to study pericyte contractility and responses to ischaemia in vitro using electrical impedance (2017) (34)
Improving accountability through alignment: the role of academic health science centres and networks in England (2014) (34)
Failure of the Lipid Peroxidation Inhibitor, U74006F, to Prevent Postischemic Selective Neuronal Injury (1992) (34)
Alteration in NMDA receptor subunit mRNA expression in vulnerable and resistant regions of in vitro ischemic rat hippocampal slices (1997) (33)
Endovascular Stroke Treatment Today (2011) (33)
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
Organised stroke care increases the numbers and the speed with which patients with acute ischemic stroke are thrombolysed (2002) (32)
The probability of middle cerebral artery MRA flow signal abnormality with quantified CT ischaemic change: targets for future therapeutic studies (2004) (32)
Stroke syndromes and clinical management. (2013) (32)
Neuroprotective effects of omega-Aga-IVA against in vitro ischaemia in the rat hippocampal slice. (1995) (31)
Personalized medical education: Reappraising clinician-scientist training (2016) (31)
Thrombolytic agents for acute ischaemic stroke treatment: the past, present and future. (2013) (30)
Organizational models of emerging academic health science centers in England. (2010) (30)
The validity and reliability of a novel quantitative CT score in predicting outcome prior to thrombolytic treatment (2000) (30)
Evidence for more widespread cerebral pathology in early HD: An MRI-based morphometric analysis. Authors' reply (2004) (30)
Comparison of the changes in protein kinase C induced by glutamate in primary cortical neurons and by in vivo cerebral ischaemia. (1998) (29)
Organisational culture and post-merger integration in an academic health centre: a mixed-methods study (2015) (29)
Preliminary Evidence of a High Risk of Bleeding on Aspirin plus Clopidogrel in Aspirin-Naïve Patients in the Acute Phase after TIA or Minor Ischaemic Stroke (2010) (28)
Creating a more supportive and inclusive university culture: a mixed-methods interdisciplinary comparative analysis of medical and social sciences at the University of Oxford (2019) (28)
Rapamycin in ischemic stroke: Old drug, new tricks? (2018) (28)
A Novel Method to Derive Separate Gray and White Matter Cerebral Blood Flow Measures from MR Imaging of Acute Ischemic Stroke Patients (2005) (27)
The imperative to develop dedicated stroke centers. (2000) (27)
Predictors of stroke outcome. (2000) (26)
Rapid Evaluation after High-Risk TIA is Associated with Lower Stroke Risk (2009) (26)
Blocked angiogenesis in Galectin-3 null mice does not alter cellular and behavioral recovery after middle cerebral artery occlusion stroke (2014) (25)
Implementation of collaborative governance in cross-sector innovation and education networks: evidence from the National Health Service in England (2014) (24)
Leukoaraiosis and lacunes are associated with poor clinical outcomes in ischemic stroke patients treated with intravenous thrombolysis (2016) (24)
Short-term prognosis following acute cerebral ischaemia (2002) (24)
ASPECTS reading requires training and experience. (2003) (23)
The gender effect in stroke thrombolysis: Of CASES, controls and treatment-effect modification (2008) (23)
Differential Effects of Paracrine Factors on the Survival of Cells of the Neurovascular Unit during Oxygen Glucose Deprivation (2015) (23)
Differentiating Grades of Microglial Activation with Fractal Analysis (2008) (23)
Tissue Window in Stroke Thrombolysis Study (TWIST): A Safety Study (2013) (23)
The Canadian Activase for Stroke Effectiveness Study (CASES): Interim results (2000) (23)
Mechanisms of 1S,3R-ACPD-induced neuroprotection in rat hippocampal slices subjected to oxygen and glucose deprivation (1996) (23)
Laser Doppler flowmetry to measure changes in cerebral blood flow. (2014) (23)
The fast assessment of stroke and transient ischemic attack to prevent early recurrence (FASTER) trial (2003) (23)
BOX-COUNTING ANALYSIS OF MICROGLIA FORM IN SCHIZOPHRENIA, ALZHEIMER'S DISEASE AND AFFECTIVE DISORDER (2008) (23)
Mild Neurological Symptoms Despite Middle Cerebral Artery Occlusion (2004) (22)
Should You Thrombolyze All or Any Stroke Patients with Baseline National Institutes of Health Stroke Scale Scores ≤5? (2009) (22)
The Utility of Animal Ischemia Models in Predicting Pharmacotherapeutic Response in the Clinical Setting. (1989) (21)
NXY-059: brain or vessel protection. (2006) (21)
The role of the endoplasmic reticulum stress response following cerebral ischemia (2018) (21)
Effectiveness of tissue-type plasminogen activator for acute ischemic stroke: Consequences of protocol violation (1999) (21)
CoQ10 fails to protect brain against focal and global ischemia in rats (2000) (21)
Alteplase Treatment does not Increase Brain Injury After Mechanical Middle Cerebral Artery Occlusion in the Rat (2013) (20)
Markers of achievement for assessing and monitoring gender equity in translational research organisations: a rationale and study protocol (2016) (19)
The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies (2018) (19)
Effect of Athena SWAN funding incentives on women’s research leadership (2020) (19)
Effect of temperature in focal ischemia of rat brain studied by 31P and 1H spectroscopic imaging (1997) (18)
Animal models. (2000) (18)
Fluid-attenuated inversion recovery preparation: not an improvement over conventional diffusion-weighted imaging at 3T in acute ischemic stroke. (2004) (18)
U74006F REDUCES NEOCORTICAL INFARCTION BUT DOES NOT ATTENUATE SELECTIVE HIPPOCAMPAL CA1 NECROSIS (1990) (17)
Exploration of P-type Ca2+ Channels as Drug Targets for the Treatment of Epilepsy or Ischemic Stroke (1997) (17)
Symptomatic hemorrhage after alteplase therapy not due to silent ischemia (2001) (17)
Orolingual angioedema after alteplase treatment of stroke is associated with angiotensin converting enzyme inhibitor use (2002) (17)
A comparison of CT versus MR imaging in acute stroke using ASPECTS: Will the “new” replace the “old” as the preferred imaging modality? (2001) (17)
Suppression of the inflammatory response by diphenyleneiodonium after transient focal cerebral ischemia (2012) (15)
CT assessment of conjugate eye deviation in acute stroke (2003) (15)
ARE THE NEUROPROTECTIVE EFFECTS OF MK-801 MEDIATED BY HYPOTHERMIA (1989) (15)
Circadian Biology and Stroke. (2021) (14)
Correlation of Neurologic Dysfunction with CT Findings in Early Acute Stroke (1999) (14)
Functional Neurological Disorder: A Common and Treatable Stroke Mimic. (2020) (13)
Gender parity in scientific authorship in a National Institute for Health Research Biomedical Research Centre: a bibliometric analysis (2021) (13)
Lessons in experimental ischemia for clinical stroke medicine (2003) (13)
Early CT scoring system predicts hemorrhage and outcome after intravenous thrombolytic therapy (1999) (13)
Impact of acute stroke unit on hospital length of stay. (2009) (12)
Stroke: management and prevention (2008) (11)
Postgraduate medical education in England: 100 years of solitude (2011) (11)
Insular cortical ischaemia does not independently predict acute hypertension or hyperglycaemia within 3 h of onset (2006) (11)
Structural Transformation to Attain Responsible BIOSciences (STARBIOS2): Protocol for a Horizon 2020 Funded European Multicenter Project to Promote Responsible Research and Innovation (2018) (11)
In vivo Binding of [3H]Nimodipine in Rat Brain after Transient Forebrain Ischemia (1994) (11)
Translational vehicles for neuroprotection. (2006) (10)
Intravenous Thrombolysis for Acute Ischaemic Stroke in Young Adult Patients (2009) (10)
A case of cocaine-induced basilar artery thrombosis (2008) (10)
THE TIME COURSE FOR INFARCTION IN A RAT MODEL OF TRANSIENT FOCAL ISCHEMIA (1990) (10)
*North American Symptomatic Carotid Endarterectomy Trial (NASCET) Steering Committee. Clinical Alert: Benefit of Carotid Endarterectomy for Patients with High-Grade Stenosis of the Internal Carotid Artery (1991) (10)
Does the Application of X-Ray Contrast Agents Impair the Clinical Effect of Intravenous Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients? (2012) (10)
C-EPO: Ready for Prime-Time Preconditioning? (2005) (10)
Development and efficacy of NXY-059 for the treatment of acute ischemic stroke (2008) (10)
Rapamycin Induces an eNOS (Endothelial Nitric Oxide Synthase) Dependent Increase in Brain Collateral Perfusion in Wistar and Spontaneously Hypertensive Rats (2020) (10)
Assessing the Quality and Reproducibility of a Proteomic Platform for Clinical Stroke Biomarker Discovery (2010) (9)
Multi-modal assessment of neurovascular coupling during cerebral ischaemia and reperfusion using remote middle cerebral artery occlusion (2016) (9)
Infarction of the Spinal Cord. (1985) (9)
Neuroprotection and neurogenesis: Modulation of cornus ammonis 1 neuronal survival after transient forebrain ischemia by prior fimbria-fornix deafferentation (2006) (9)
THE NMDA RECEPTOR-ION CHANNEL - ITS IMPORTANCE TO INVIVO ISCHEMIC-INJURY TO SELECTIVELY VULNERABLE NEURONS (1990) (9)
Stroke prevention (2005) (9)
The eyes have it: conjugate eye deviation on CT scan aids in early detection of ischemic stroke. (2003) (9)
Stroke in the very old: clinical presentations and outcomes. (2008) (9)
The Canadian activase for stroke effectiveness study (2000) (9)
The Alberta stroke program early CT score (ASPECTS) performed in real time shows good agreement with expert rating (2004) (9)
Presence of DWI lesion an acute MRI in minor stroke and TIA patients predicts recurrent stroke and clinical outcome (2005) (8)
Antagonists of Excitatory Amino Acid Neurotransmitters: A comparison of their effects on global versus focal ischemia. (1992) (8)
Cost utility analysis of intravenous tissue plasminogen activator in acute ischemic stroke in Canada (2003) (8)
Thrombolytic therapy for acute ischemic stroke - The CAEP Position Statement: another perspective. (2001) (8)
Thrombolysis must be considered after stroke (2001) (8)
New indicators and indexes for benchmarking university–industry–government innovation in medical and life science clusters: results from the European FP7 Regions of Knowledge HealthTIES project (2019) (8)
Reliable computer assisted measurement of stroke lesion volumes (2002) (7)
Doubts, Fears and Misconceptions. What is the Future of Thrombolysis in Acute Stroke? (2000) (7)
Implementation of collaborative governance in cross-sector innovation and education networks: evidence from the National Health Service in England (2014) (7)
Gonococcal peritonitis in a patient treated with continuous ambulatory peritoneal dialysis (CAPD). (1985) (7)
Organization of regional and local stroke resources: Methods to expedite acute management of stroke (2004) (7)
Markers of achievement for assessing and monitoring gender equity in a UK National Institute for Health Research Biomedical Research Centre: A two-factor model (2020) (7)
NMDA and AMPA Receptor Antagonists in Global and Focal Ischemia (1996) (7)
Mobile acute stroke units: bringing the hospital to the patient (2012) (6)
Aspects of Stroke Imaging (2001) (6)
Stroke Effectiveness Study acute ischaemic stroke: Canadian Alteplase for Thrombolysis in patients older than 80 years with (2006) (6)
Stroke thrombolysis: is tissue plasminogen activator a defibrillator for the brain? (2000) (6)
AM last page: funding of academic research in clinical medicine in the United Kingdom. (2014) (6)
Hyperacute stroke: experience essential when reading unenhanced CT scans. (2004) (6)
The hyperdense sylvian fissure MCA "dot" sign: a marker of acute CT ischemia (2001) (5)
MODERATE HYPOTHERMIA PREVENTS FOCAL INFARCTION (1991) (5)
Thrombolysis for acute ischemic stroke in patients older than 80 years (2006) (5)
Stroke and Hypoxic-Ischemic Disorders. (1992) (5)
MK-801 REDUCES THE VOLUME OF NEOCORTICAL INFARCTION BUT ALSO INCREASES REGIONAL CEREBRAL BLOOD-FLOW (1990) (5)
Concerns over lindane treatment for scabies and lice (2003) (5)
Investigation of the novel mTOR inhibitor AZD2014 in neuronal ischemia (2019) (5)
Strategies for therapy in acute ischemic stroke (2007) (4)
Acute Neurovascular Syndromes: Hurry Up, Please, It’s Time1 (2004) (4)
The cost of providing mechanical thrombectomy in the UK NHS: a micro-costing study. (2020) (4)
Medical workforce education and training: A failed decentralisation attempt to reform organisation, financing, and planning in England. (2015) (4)
Pre-Clinical Studies of Glutamate Receptor Antagonists for the Treatment of Cerebral Ischemia. (1999) (4)
Cataract surgery after acute stroke: maybe more than a coincidence. (2006) (4)
The neurovascular unit and systemic biology in stroke — implications for translation and treatment (2022) (4)
Neuroprotection in Acute Ischemic Stroke: A Brief Review (2021) (4)
Is glucose a predictor of hemorrhage after rtPA therapy in acute stroke (1998) (4)
Indefatigable protection with prolonged mild hypothermia following experimental focal cerebralischemia in rats (2000) (4)
Hyperacute MR imaging and clinical predictor risk score predict dependent outcome after minor stroke and TIA (2007) (4)
The risks of inappropriate carotid endarterectomy (1998) (3)
a systematic review and meta-analysis of randomized controlled trials of endovascular thrombectomy compared to best medical treatment for acute ischemic stroke (vol 10, pg 1168, 2015) (2017) (3)
Caspase inhibitors reduce neuronal injury in animal ischemic models (1999) (3)
Targeting Pericytes and the Microcirculation for Ischemic Stroke Therapy (2017) (3)
Delayed maturation of cortical infarction: Role of caspases and NF-kappa B-mediated transcription (2001) (3)
Growth Differentiation Factor-11 Causes Neurotoxicity During Ischemia in vitro (2020) (3)
Vascular Malformations and Hemorrhage of the Spinal Cord. (1985) (3)
Informed consent for thrombolytic therapy in acute ischemic stroke. (2005) (3)
Ever Decreasing Circles: Advances in Antiplatelet Therapy and Anticoagulation (2003) (3)
A method of inducing global cerebral ischemia. (2014) (3)
Baseline ASPECT Scores predict extent of stroke: Interim CT Analysis of CASES (2001) (3)
Prior deafferentation confers long term protection to CA1 against transient forebrain ischemia and sustains GluR2 expression (2006) (3)
Medical education leaders' perceptions of postgraduate medical education reform (2014) (3)
Proscript 519, proteasome inhibitor, reduces cortical neuronal injury following focal ischemia in rats (2000) (3)
Animal Models of Stroke (1997) (3)
The erythropoietin neuroprotective effect: assessment in coronary artery bypass graft surgery (TENPEAKS) – a randomized, double-blind, placebo-controlled, proof-of-concept clinical trial (2006) (3)
Validation of the ASPECT score as a predictor of outcome: Analysis of the ATLANTIS-B study (2002) (3)
Complication rates after internal carotid stenting in high-risk, symptomatic patients (2002) (3)
DELAYED TREATMENT WITH AMPA BUT NOT NMDA GLUTAMATE ANTAGONISTS REDUCES NEOCORTICAL INFARCTION (1992) (2)
Reinventing the Penumbra - the Emerging Clockwork of a Multi-modal Mechanistic Paradigm. (2022) (2)
Setting up An Acute Stroke Service (2008) (2)
The Life of Bo K. Siesjö, MD, PhD, 1930–2013 (2014) (2)
TIA reference unit: Rapid investigation and management of TIA (2003) (2)
Neuroprotective Stroke Trials: A Ten Year Dry Season (2003) (2)
DELAYED TREATMENT WITH THE OMEGA-CONOPEPTIDE SNX-111 PREVENTS NEURONAL INJURY FOLLOWING TRANSIENT FOCAL ISCHEMIA AND UP TO 24 HOURS AFTER GLOBAL-ISCHEMIA (1994) (2)
Evaluation of acute stroke with high field MR (2000) (2)
Does application of radio contrast media prior to thrombolysis impact thrombolytic effect in acute ischemic stroke (2008) (2)
A multinational multicenter investigation to identify predictors of good outcome after open label t-PA treatment in acute ischemic stroke (1999) (2)
Case costing of mechanical thrombectomy for acute ischaemic stroke in routine clinical setting:: cost differences between mothership vs drip and ship (2018) (2)
93 CURRENT AND EXPERIMENTAL TREATMENT OF STROKE (2002) (2)
Cerebroprotection in the endovascular era: an update (2022) (2)
Can pure oxygen prevent stroke damage? (2000) (2)
Endogenous Neuroprotection: Hamartin Modulates an Austere Approach to Staying Alive in a Recession (2013) (2)
Primitive Surgery: An Overview (2006) (2)
Atherothrombotic Cerebrovascular Disease. (1989) (2)
tPA Toxicity in Experimental Cerebral Ischemia: Mechanisms and Clinical Implications. (2002) (2)
Acute MRI in speech or motor TIA reveals ongoing ischemia and active disease in a high proportion of patients (2004) (2)
Time is brain: Post-marketing experience with alteplase (tPA) for acute ischemic stroke (2000) (2)
Stroke: Animal models (2007) (2)
Intra-arterial therapy following intravenous alteplase for severe ischemic stroke (2001) (1)
FIMBRIAL AND CINGULUM BUNDLE SEROTONIN AFFERENTS TO HIPPOCAMPUS (1977) (1)
Fimbria/Fornix deafferentation protects CA1 neurons and enhances neurogenesis in hippocampus following global ischemia (2003) (1)
Experimental Neuroprotection: Translation to Human Stroke Trials (2004) (1)
The cost of providing mechanical thrombectomy in the UK National Health Service: a micro-costing study (2020) (1)
A novel method demonstrates that gray and white matter have measurable differences in cerebral perfusion and apparent diffusion coefficient values in stroke penumbra (2004) (1)
Interim analysis of the Canadian activase for stroke effectiveness study: Outcome depends on time to treatment (2000) (1)
Approaches to neuroprotective and reperfusion injury therapy. (2009) (1)
MK 801 protects tissue plasminogen activator mediated neuroexcitotoxicity in permanent focal ischemia (2002) (1)
Reactions to alteplase in patients with acute thrombotic stroke. (2000) (1)
The future of stroke therapy must not be mired by past arguments (2015) (1)
Reliability in assessment of DWI/PWI mismatch (2003) (1)
Experimental study of the pathogenesis and treatment of stroke (1991) (1)
Medical Schools as Professional Workplaces (2014) (1)
Ischemic stroke in the elderly: an overview (2010) (1)
Neurovascular physiology and pathophysiology of brain pericytes (2015) (1)
MAGNETIC-RESONANCE EVALUATION OF REGIONAL BRAIN INJURY FOLLOWING CEREBRAL-ISCHEMIA (1992) (1)
A new thrombolytic drug for acute ischaemic stroke (2021) (1)
Moving Forward with Intra-Arterial and Intravenous Stroke Treatment (2007) (1)
DNA FRAGMENTATION INDICATIVE OF APOPTOSIS IN BRAIN FOLLOWING ISCHEMIA (1993) (1)
Treating stroke - Response (2000) (1)
RADIOLOGIC RISK-FACTORS IN CAROTID ENDARTERECTOMY PATIENTS (1989) (1)
Improved regional cerebral blood flow mediates tolerance afforded by ischemic preconditioning (2005) (1)
Use and validity of a quantitative computed tomographic score in early cerebral ischemia (1999) (1)
FIMBRIA FORNIX LESIONS PROTECT HIPPOCAMPAL-NEURONS FROM ISCHEMIC DAMAGE (1988) (1)
Circulating Transforming Growth Factor- (cid:1) 1 Levels in Asymptomatic Carotid Plaques to the (2005) (1)
Transient increases in blood pressure affect sensory-motor activation following stroke using functional MR imaging in the rat (2005) (0)
t-PA does not promote apoptosis in two animal models of cerebral ischemia (1998) (0)
NXY-059, a novel free radical trapping agent, reduces cortical infarction after permanent focal ischaemia in rats (2000) (0)
Understanding and managing ischemic stroke 1 (0)
Magnetic resonance imaging may be a useful modality for targeting "true" ischemia in stroke prevention and a surrogate marker for limiting sample size requirement for a trial (2005) (0)
Homocysteinemia, fibromusclar dysplasia and stroke: A case report (2004) (0)
Organization of Stroke Services in the Community and the Hospital. (2010) (0)
Characterization of hypoxia inducible factor pathway in neuroprotection and neurorestoration following cerebral ischaemia (2013) (0)
Effects of NXY-059 on Cerebral Blood Flow (2006) (0)
Highlights of the 8th International Symposium Thrombolysis and Acute Stroke Therapy held June 19-22, 2004, Whistler, BC, Canada (2004) (0)
LARGE REGIONAL DROP IN STROKE ADMISSIONS COINCIDENT WITH INITIATION OF A HIGH VOLUME RAPID ASSESSMENT UNIT FOR TIA AND MILD STROKE (2009) (0)
The Biochemistry of Ischemia. (2003) (0)
CJN volume 28 issue 3 Cover and Front matter (2001) (0)
NXY-059: Brain or vessel protection. (vol 37, pg 2189, 2006) (2006) (0)
Corrigendum to a systematic review and meta-analysis of randomized controlled trials of endovascular thrombectomy compared to best medical treatment for acute ischemic stroke (2017) (0)
Matrix Metalloproteinases and Tissue Plasminogen Activator Reperfusion Therapy for Stroke (2007) (0)
P-31 AND H-1 SPECTROSCOPIC IMAGING STUDIES OF FOCAL ISCHEMIA IN RAT-BRAIN (1995) (0)
Why don't stroke patients receive tissue plasminogen activator? An analysis of patient eligibility: Implications for improving clinical impact by increasing future treatment numbers (2000) (0)
Intracerebral haemorrhage: a need for more data and new research directions (2010) (0)
1297 Insular cortical ischemia is associated with but does not predict acute hypertension and is not related to acute hyperglycemia (2005) (0)
Interpretation of ESPRIT in the FASTER trial – Authors' reply (2008) (0)
Hypothermia following cerebral ischemia provides neuroprotection but is not beneficial toward neurogenesis (2005) (0)
REVIEW ARTICLE Endovascular Stroke Treatment Today (2011) (0)
Is alteplase safe and effective in routine clinical practice for patients with ischemic stroke? (2007) (0)
3:27 PM Abstract No. 258 Outcomes of mechanical thrombectomy using the Inari FlowTriever system for the treatment of acute pulmonary embolism (2020) (0)
Expanding horizons in the endovascular treatment of stroke: larger cores and adjunct thrombolytics. (2022) (0)
Do caspase and proteasome inhibitors influence the delayed maturation of cortical infarction by preventing apoptosis or neuroinflammation (2000) (0)
Tuberous Sclerosis Complex-1 (TSC1) contributes to selective neuronal vulnerability in Alzheimer's Disease. (2023) (0)
CT-CT angiography mismatch predicts penumbra (DWI-PWI mismatch) (2005) (0)
A161 POSTOPERATIVE HBUROLOGICAL FUNCTION IN PATIENTS UNDERGOING ELECTIVE CORONARY ARTERY SURGERYA PROSPECTIVE STUDY (1990) (0)
Neuroprotective effects of ω‐Aga‐IVA against in vitro ischaemia in the rat hippocampal slice (1995) (0)
Therapeutic Strategies Harnessing Oxidative Stress to Treat Stroke (2017) (0)
Application of Neuroprotective Agents in Animal Models of Ischemic Stroke (2010) (0)
Reply: Intravenous thrombolysis for ischaemic strokes: a call for reappraisal. (2015) (0)
Acute ischemic stroke: Transcending the boundaries of therapeutic intervention. (2010) (0)
Treatment of the patient with acute ischemic stroke (1998) (0)
Recent advances in the treatment of acute ischemic stroke (1993) (0)
Protective effect of prior fimbria-fornix deafferentation on hippocampal CA1 following transient forebrain ischemia is mediated by GluR2 expression (2005) (0)
Clinical and Experimental Stroke (2000) (0)
A survey to explore new markers of achievement to assess and monitor gender equity in an NIHR Biomedical Research Centre: A two-factor model (2020) (0)
Safety of thrombolysis given both inside and 'out of the NINDS box' (2004) (0)
Cerebral Ischemia: Molecular and Cellular Pathophysiology . 1st Edition. 1999. Edited by Wolfgang Walz. Published by Humana Press Inc. 278 pages. C$181.25 approx. (2001) (0)
Glutamate receptor subunit 2 (GluR2) expression mediates protection conferred to CA1 neurons from ischemic damage by prior fimbria-fornix deafferentation (2005) (0)
Predicting functional outcome after intra-arterial thrombolysis: Aspects of ASPECTS - Response (2004) (0)
Nomenclature for using MR as a new lesion surrogate outcome (2004) (0)
Posterior cerebral artery stroke (2003) (0)
Conspicuity of Acute Stroke Lesions on Fluid Attenuated Inversion Recovery Diffusion-weighted Imaging and Conventional Diffusion-weighted Imaging (2010) (0)
Comparative evaluation of the effect of postischemic hypothermia and differentiation following global ischemia on CA1 pyramidal neuronal survival (2004) (0)
Excitotoxicity: Theory and Practice of Glutamate Antagonists. (2000) (0)
The effects of prolonged mild hypothermia on neurogenesis following transient focal cerebral ischemia (2004) (0)
Intra-arterial thrombolysis for hyperacute stroke (2000) (0)
A retrospective analysis of gender parity in scientific authorship in a biomedical research centre (2020) (0)
Abstract 81: Shear-activated Nanoparticle Aggregates Containing Nitroglycerin Selectively Increase Collateral Perfusion During Experimental Ischemic Stroke (2022) (0)
Research report Dehydroepiandrosterone (DHEA) reduces neuronal injury in a rat model of global cerebral ischemia (2001) (0)
TIME COURSE OF PERICYTE CONSTRICTION OF CAPILLARIES FOLLOWING TRANSIENT MIDDLE CEREBRAL ARTERY OCCLUSION (2016) (0)
ASTROCYTES CONTRIBUTE TO THE CEREBRAL BLOOD FLOW RESPONSE TO HYPERCAPNIA (2016) (0)
Organisational culture and post-merger integration in an academic health centre: a qualitative study (2014) (0)
Growth differentiation factor-11 causes neurotoxicity during oxygen and glucose deprivation in vitro (2017) (0)
Reply: Thrombolysis in acute ischaemic stroke. (2014) (0)
Enhanced inflammation may be the mechanism of tissue plasminogen activator toxicity in a rat model of permanent focal ischemia (2001) (0)
Intra-arterial thrombolysis for hyperacute stroke - Reply (2000) (0)
Cerebrovascular Disease: Ischemic Disorders. (1989) (0)
New indicators and indexes for benchmarking university-industry-government innovation in medical and life science clusters: Results from European FP7 Regions of Knowledge project HealthTIES (2019) (0)
The effects of fasting on ischemic infarcts in the rat (2022) (0)
Why stroke patients don't receive t-PA? An analysis of patient eligibility: Implications for improving clinical impact by increasing future treatment numbers (2001) (0)
N-Methyl-D-Aspartate Excitotoxicity: Is It Important in Ischemic Neuronal Injury? (1991) (0)
Guidelines on RRI implementation in biosciences organisations (2019) (0)
5thInternational Workshop Maturation Phenomenon in Cerebral Ischemia Round Table Discussion (2004) (0)
Abstract WP151: Rapamycin Improves Post-Recanalization Blood Flow After Acute Experimental Stroke in Rats (2020) (0)
Minor stoke and TIA are not benign (2004) (0)
Letter by Harston et al Regarding Article, "Alberta Stroke Program Early CT Score Versus Computed Tomographic Perfusion to Predict Functional Outcome After Successful Reperfusion in Acute Ischemic Stroke". (2018) (0)
Association of serotonin transporter gene promoter region polymorphism with post-stroke major depression (2005) (0)
Feasibility of designing an early stroke prevention trial using novel nomenclature to capture all clinical and MRI end points (2006) (0)
Microbleeds and intravenous thrombolytic therapy in acute ischemic stroke (2005) (0)
Imaging of small vessels disease predicts outcomes in ischemic stroke patients treated with intravenous thrombolysis (2014) (0)
CJN volume 27 issue 4 Cover and Front matter (2000) (0)
Interval times improve with experience: Interim analysis of the CASES study (2000) (0)
A comparison of CT versus MR imaging is hyperacute stroke using a topographical quantitative scoring system (ASPECTS) (2001) (0)
Acute Therapy for Stroke in the Elderly. (2010) (0)
Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging (2023) (0)
Stroke care: the way forward (2003) (0)
Acute stroke treatment: the end of the first decade (2006) (0)
NEUROPROTECTIVE PROFILE OF FPL-15896AR, A NOVEL UNCOMPETITIVE NMDA ANTAGONIST (1995) (0)
A comparison study of CT hyperdense artery signs with magnetic resonance angiography in acute stroke (2002) (0)
Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation (2017) (0)
Acute ischaemic stroke. Thrombolysis for acute ischaemic stroke works. (2000) (0)
Getting to Transient Ischemic Attacks Early. (2010) (0)
Use of magnetic resonance imaging in predicting further vascular events among patients with transient ischemic attacks. (2005) (0)
From Bench to Bedside: Evolving Experimental MR Imaging Technology for Cerebral Ischemia. (2010) (0)
No Morphological Evidence of Apoptosis Following Mild to Severe Episodes of Four-Vessel-Occlusion Ischemia in Rats (1999) (0)
Clinical outcome of intracerebral hemorrhage and clinical correlation for disability and death. (2007) (0)
Consequences of tissue plasminogen activator protocol violation (1998) (0)
Feasibility of using follow-up MRI as a measure of treatment outcome in patients with acute TIA or minor stroke (2004) (0)
A comparison of CT versus diffusion weighted imaging in hyperacute stroke using a systematic quantitative score (ASPECTS) (2002) (0)
Investigating the temperature‐dependent and independent neuroprotective effects of cyclohexyladenosine in SH‐SY5Y neurons undergoing oxygen glucose deprivation (2022) (0)
Commentary: Rapalink-1 Increased Infarct Size in Early Cerebral Ischemia–Reperfusion With Increased Blood–Brain Barrier Disruption (2021) (0)
Hypothermia but not nmda receptor antagonist mk-801 attenuates neuron damage: Are the results conclusive? (1992) (0)

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