Alberto Julio Kaumann

Alberto Julio Kaumann's AcademicInfluence.com Rankings

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#2719

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#3151

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#260

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#266

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#302

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#351

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Alberto Julio Kaumann

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#7778

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#11033

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#4816

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#6145

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Alberto Julio Kaumann's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

β3 and Atypical β‐Adrenoceptors (1993) (293)
5-hydroxytryptamine receptors in the human cardiovascular system. (2006) (273)
Is there a third heart β-adrenoceptor? (1989) (193)
Prevention of ventricular fibrillation induced by coronary ligation. (1968) (187)
A 5‐hydroxytryptamine receptor in human atrium (1990) (182)
Autoradiographical Localization of Binding Sites for Porcine [125I]Endothelin‐1 in Humans, Pigs, and Rats: Functional Relevance in Humans (1989) (179)
Selective beta 1-adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through beta 2-adrenoceptors in human atrial myocardium. (1990) (176)
Differences between the third cardiac β‐adrenoceptor and the colonic β3‐adrenoceptor in the rat (1996) (172)
Variable Participation of 5‐HT1‐Like Receptors and 5‐HT2 Receptors in Serotonin‐Induced Contraction of Human Isolated Coronary Arteries: 5‐HT1‐Like Receptors Resemble Cloned 5‐HT1Dβ Receptors (1994) (165)
Modulation of human cardiac function through 4 β-adrenoceptor populations (1997) (149)
Do human atrial 5-HT4 receptors mediate arrhythmias? (1994) (140)
A comparison of the effects of adrenaline and noradrenaline on human heart: the role of beta 1- and beta 2-adrenoceptors in the stimulation of adenylate cyclase and contractile force. (1989) (136)
Four β-adrenoceptor subtypes in the mammalian heart (1997) (125)
Epinephrine activates both Gs and Gi pathways, but norepinephrine activates only the Gs pathway through human beta2-adrenoceptors overexpressed in mouse heart. (2004) (124)
Activation of beta2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure. (1999) (122)
5-HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle (2001) (117)
Coexistence of functioning beta 1- and beta 2-adrenoceptors in single myocytes from human ventricle. (1993) (111)
Abolition of (-)-CGP 12177-evoked cardiostimulation in double β1/β2-adrenoceptor knockout mice. Obligatory role of β1-adrenoceptors for putative β4-adrenoceptor pharmacology (2000) (107)
(—)‐CGP 12177‐induced increase of human atrial contraction through a putative third β‐adrenoceptor (1996) (107)
Studies on receptor-mediated activation of adenylyl cyclases. IV. Characteristics of the adrenergic receptor coupled to myocardial adenylyl cyclase: stereospecificity for ligands and determination of apparent affinity constants for beta-blockers. (1974) (99)
(-)-CGP 12177 causes cardiostimulation and binds to cardiac putative beta 4-adrenoceptors in both wild-type and beta 3-adrenoceptor knockout mice. (1998) (96)
Efficacy of beta 1-adrenergic receptors is lower than that of beta 2-adrenergic receptors. (1993) (96)
Direct labelling of beta 2-adrenoceptors. Comparison of binding potency of 3H-ICI 118,551 and blocking potency of ICI 118,551. (1985) (94)
Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i) (2004) (91)
Human arterial constrictor serotonin receptors. (1993) (87)
Beta 2-adrenoceptor-mediated positive inotropic effect of adrenaline in human ventricular myocardium. Quantitative discrepancies with binding and adenylate cyclase stimulation. (1987) (83)
The affinity of (-)-propranolol for beta 1- and beta 2-adrenoceptors of human heart. Differential antagonism of the positive inotropic effects and adenylate cyclase stimulation by (-)-noradrenaline and (-)-adrenaline. (1985) (83)
Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure. (2005) (81)
Adrenergic receptors in heart muscle: relations among factors influencing the sensitivity of the cat papillary muscle to catecholamines. (1970) (75)
Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation (2014) (74)
Pharmacology of portal-systemic collaterals in portal hypertensive rats: role of endothelium. (1992) (74)
Catecholamines Relax Detrusor through β2-Adrenoceptors in Mouse and β3-Adrenoceptors in Man (2009) (72)
Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure (2004) (72)
Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. (1992) (69)
BIBN4096BS is a potent competitive antagonist of the relaxant effects of α‐CGRP on human temporal artery: comparison with CGRP(8‐37) (2002) (63)
The low-affinity site of the beta1-adrenoceptor and its relevance to cardiovascular pharmacology. (2008) (63)
The affinity of (−)-propranolol for β1- and β1-autoreceptors of human heart (1985) (62)
Both &bgr;2- and &bgr;1-Adrenergic Receptors Mediate Hastened Relaxation and Phosphorylation of Phospholamban and Troponin I in Ventricular Myocardium of Fallot Infants, Consistent With Selective Coupling of &bgr;2-Adrenergic Receptors to Gs-Protein (2000) (62)
Putative β4‐adrenoceptors in rat ventricle mediate increases in contractile force and cell Ca2+: comparison with atrial receptors and relationship to (−)‐[3H]‐CGP 12177 binding (1999) (62)
The contribution of classical (beta1/2-) and atypical beta-adrenoceptors to the stimulation of human white adipocyte lipolysis and right atrial appendage contraction by novel beta3-adrenoceptor agonists of differing selectivities. (1998) (62)
Sensitization of Human Atrial 5-HT4 Receptors by Chronic β-Blocker Treatment (1995) (61)
PROPOSAL FOR THE INTERACTION OF NON‐CONVENTIONAL PARTIAL AGONISTS AND CATECHOLAMINES WITH THE ‘PUTATIVE (β‐ADRENOCEPTOR’ IN MAMMALIAN HEART (1997) (61)
Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase (1992) (59)
Effects of the novel high-affinity 5-HT(1B/1D)-receptor ligand frovatriptan in human isolated basilar and coronary arteries. (1998) (58)
(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the β1-adrenoceptor (2002) (57)
Phosphodiesterase‐4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (−)‐adrenaline mediated through mouse cardiac β1‐adrenoceptors (2008) (56)
Contractile and arrhythmic effects of endothelin receptor agonists in human heart in vitro: blockade with SB 209670. (2000) (55)
5-Hydroxytryptamine causes rate-dependent arrhythmias through 5-HT4 receptors in human atrium: facilitation by chronic β-adrenoceptor blockade (1994) (55)
Regional differences of beta 1- and beta 2-adrenoceptor-mediated functions in feline heart. A beta 2-adrenoceptor-mediated positive inotropic effect possibly unrelated to cyclic AMP. (1991) (55)
β2-Adrenoceptor-mediated positive inotropic effect of adrenaline in human ventricular myocardium (1987) (55)
Comparison of the affinity of β‐blockers for two states of the β1‐adrenoceptor in ferret ventricular myocardium (2002) (53)
Markedly reduced effects of (−)‐isoprenaline but not of (−)‐CGP12177 and unchanged affinity of β‐blockers at Gly389‐β1‐adrenoceptors compared to Arg389‐β1‐adrenoceptors (2004) (53)
Piglet sinoatrial 5-HT receptors resemble human atrial 5-HT4-like receptors (1990) (52)
Inotropy and L‐type Ca2+ current, activated by β1‐ and β2‐adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart (2009) (51)
Blockade of human atrial 5‐HT4 receptors by GR 113808 (1993) (50)
Abolition of (-)-CGP 12177-evoked cardiostimulation in double beta1/beta2-adrenoceptor knockout mice. Obligatory role of beta1-adrenoceptors for putative beta4-adrenoceptor pharmacology. (2001) (49)
Contribution of β1‐ and β2‐adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (−)‐atenolol (1988) (49)
(-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through β2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling (2007) (48)
L-type calcium current and contractility in ventricular myocytes from mice overexpressing the cardiac β2-adrenoceptor (1999) (48)
Binding of (−)-[3H]-CGP12177 at two sites in recombinant human β1-adrenoceptors and interaction with β-blockers (2004) (47)
Relationship between the stereoselective negative inotropic effects of verapamil enantiomers and their binding to putative calcium channels in human heart (1985) (46)
Cardiostimulant and cardiodepressant effects through overexpressed human β2-adrenoceptors in murine heart: regional differences and functional role of β1-adrenoceptors (2003) (46)
Intrinsic sympathomimetic activity of (-)-pindolol mediated through a (-)-propranolol-resistant site of the β1-adrenoceptor in human atrium and recombinant receptors (2003) (45)
On the statistics of drug-receptor constants for partial agonists. (1976) (44)
Heart β-Adrenoceptors (1978) (44)
Direct labelling of myocardial beta 1-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency. (1985) (44)
Physiological antagonism between ventricular β1‐adrenoceptors and α1‐adrenoceptors but no evidence for β2‐ and β3‐adrenoceptor function in murine heart (2002) (43)
Receptors and acceptors: a necessary distinction in hormone binding studies. (1974) (43)
Modulation of human cardiac function through 4 beta-adrenoceptor populations. (1997) (42)
A 5-HT4-like receptor in human left atrium (1992) (41)
Octimibate, a potent non‐prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor (1991) (40)
Potentiation of the effects of isoprenaline and noradrenaline by hydrocortisone in cat heart muscle (2004) (40)
Beta 3 and atypical beta-adrenoceptors. (1993) (37)
β2-Adrenoceptor activation by zinterol causes protein phosphorylation, contractile effects and relaxant effects through a cAMP pathway in human atrium (1996) (37)
The β3‐adrenoceptor agonist mirabegron increases human atrial force through β1‐adrenoceptors: an indirect mechanism? (2017) (36)
Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of β-adrenoceptor subtypes in the dissociation between blockade and stimulation (1984) (35)
Cilostamide potentiates more the positive inotropic effects of (−)-adrenaline through β2-adrenoceptors than the effects of (−)-noradrenaline through β1-adrenoceptors in human atrial myocardium (2006) (34)
THE CARDIOVASCULAR EFFECTS OF N-(GAMMA-METHYLAMINOPROPYL-IMINO-DIBENZYL)-HCL (DESMETHYLIMIPRAMINE) AND GUANETHIDINE. (1965) (32)
β-Adrenoceptor blocking agents as partial agonists in isolated heart muscle: Dissociation of stimulation and blockade (1980) (32)
Stimulant and depressant effects of beta-adrenoceptor blocking agents on isolated heart muscle. A positive inotropic effect not mediated through andrenoceptors. (1980) (31)
Labelling with [125I]‐SB 207710 of a small 5‐HT4 receptor population in piglet right atrium: functional relevance (1995) (30)
Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants (2005) (29)
Comparative assessment ofβ-adrenoceptor blocking agents as simple competitive antagonists in isolated heart muscle: Similarity of inotropic and chronotropic blocking potencies against isoproterenol (1980) (29)
The antimigraine drugs ergotamine and dihydroergotamine are potent 5‐HT1C receptor agonists in piglet choroid plexus (1991) (29)
Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers. (2004) (28)
5-HT4-like receptors in mammalian atria. (1991) (28)
Comparison of the densities of 5-HT4 receptors, β1- and β2-adrenoceptors in human atrium: functional implications (1996) (28)
Human atrial β1L‐adrenoceptor but not β3‐adrenoceptor activation increases force and Ca2+ current at physiological temperature (2011) (27)
Markedly reduced effects of (-)-isoprenaline but not of (-)-CGP12177 and unchanged affinity of beta-blockers at Gly389-beta1-adrenoceptors compared to Arg389-beta1-adrenoceptors. (2004) (27)
A paradox: the 5-HT2-receptor antagonist ketanserin restores the 5-HT-induced contraction depressed by methysergide in large coronary arteries of calf (2004) (27)
Heart ß-Receptors: On the Functional Role of Heterogeneous Binding Sites (1983) (27)
Action potential shortening through the putative β4‐adrenoceptor in ferret ventricle: comparison with β1‐ and β2‐adrenoceptor‐mediated effects (1998) (26)
Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart. (2006) (26)
Four beta-adrenoceptor subtypes in the mammalian heart. (1997) (26)
Both β1- and β2-adrenoceptors mediate catecholamine-evoked arrhythmias in isolated human right atrium (1993) (26)
Iodohydroxybenzylpindolol: preparation, purification, localization of its iodine to the indole ring, and characterization as a partial agonist. (1980) (25)
(+/-) 3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: a conformationally restricted analogue of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor. (1993) (25)
Two classes of myocardial 5-hydroxytryptamine receptors that are neither 5-HT1 nor 5-HT2. (1985) (25)
β4-Adrenoceptors are more effective than β1-adrenoceptors in mediating arrhythmic Ca2+ transients in mouse ventricular myocytes (1999) (25)
The β2-adrenoceptor antagonist CGP 20712 A unmasks β2-adrenoceptors activated by (−)-adrenaline in rat sinoatrial node (1986) (25)
Blockade of putative β4- and β1-adrenoceptors by carvedilol in ferret myocardium (1999) (24)
Functional 5-HT receptors in human occipital artery (2004) (24)
The function of α‐ and β‐adrenoceptors of the saphenous artery in caveolin‐1 knockout and wild‐type mice (2007) (24)
ICI 169,369 selectively blocks 5-hydroxytryptamine2 receptors and lowers portal pressure in portal hypertensive rats. (1988) (24)
Both beta(2)- and beta(1)-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of Fallot infants, consistent with selective coupling of beta(2)-adrenergic receptors to G(s)-protein. (2000) (24)
Pertussis toxin suppresses carbachol-evoked cardiodepression but does not modify cardiostimulation mediated through β1- and putative β4-adrenoceptors in mouse left atria: no evidence for β2- and β3-adrenoceptor function (2000) (23)
A model for the interaction of competitive antagonists with two receptor-subtypes characterized by a schild-plot with apparent slope unity (1983) (23)
Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor. (1993) (22)
Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle (2006) (22)
The effects of both noradrenaline and CGP12177, mediated through human β1-adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells (2007) (21)
An initial characterization of human heart β-adrenoceptors and their mediation of the positive inotropic effects of catecholamines (1982) (21)
Gs protein-coupled receptors in human heart (2000) (21)
On equilibrium dissociation constants for complexes of drug-receptor subtypes (1982) (21)
Phosphodiesterases do not limit β1-adrenoceptor-mediated sinoatrial tachycardia: evidence with PDE3 and PDE4 in rabbits and PDE1–5 in rats (2009) (20)
Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (−)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium (2009) (20)
Chronic β1-adrenoceptor blockade sensitises the H1 and H2 receptor systems in human atrium: role of cyclic nucleotides (1996) (20)
A novel analysis of concentration-dependence of partial agonism (1982) (20)
Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors (1983) (20)
Direct labelling of β2-adrenoceptors (2004) (19)
Comparison of the densities of 5-HT4 receptors, beta 1- and beta 2-adrenoceptors in human atrium: functional implications. (1996) (19)
On spare beta-adrenoceptors of inotropic effect of catecholamines in kitten ventricle. (1978) (19)
In kitten ventricular myocardium, the inotropic potency of an agonist is determined by both its intrinsic activity for the adenylyl cyclase and its affinity for the β-adrenoceptors (1981) (19)
Rolipram reduces the inotropic tachyphylaxis of glucagon in rat ventricular myocardium (2004) (19)
β‐Adrenoceptor Subtypes in Human Coronary Artery: Desensitization of β2-Adrenergic Vasorelaxation by Chronic β1-Adrenergic Stimulation In Vitro (1995) (18)
Primate vascular responses to octimibate, a non‐prostanoid agonist at the prostacyclin receptor (1991) (18)
On spare β-adrenoceptors for inotropic effects of catecholamines in kitten ventricle (1978) (18)
Contribution of β‐adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wildtype and β3‐adrenoceptor knockout mice (2000) (18)
Different steric characteristics of β1- and β2-adrenoceptors (1984) (18)
Cardiac pacemaking. (1978) (17)
β1‐ and β2‐adrenoceptor‐mediated relaxation in human internal mammary artery and saphenous vein: unchanged β‐ and α‐adrenoceptor responsiveness after chronic β1‐adrenoceptor blockade (1993) (17)
A comparison of the influence of N-isopropyl and N-tert butyl substituents on the affinity of ligands for sinoatrial β-adrenoceptors in rat atria and β-adrenoceptors coupled to the adenylyl cyclase in kitten ventricle (1979) (17)
Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186 (1995) (17)
3H-(−)-Bupranolol, a new β-adrenoceptor radioligand: Characterization of its binding to kitten heart β-adrenoceptors (1981) (17)
Desensitization of kitten atria to chronotropic, inotropic and adenylyl cyclase stimulating effects of (-)isoprenaline (1976) (16)
ICI 169,369 is both a competitive antagonist and an allosteric activator of the arterial 5-hydroxytryptamine2 receptor system. (1988) (16)
5-Hydroxytryptamine and Human Heart Function: The Role of 5-HT4 Receptors (1998) (16)
Interaction of ketanserin and its metabolite ketanserinol with 5HT2 receptors in pulmonary and coronary arteries of calf (1984) (16)
Phosphodiesterases reduce spontaneous sinoatrial beating but not the 'fight or flight' tachycardia elicited by agonists through Gs-protein-coupled receptors. (2011) (15)
Blockade of human atrial 5-HT4 receptors by SB 207710, a selective and high affinity 5-HT4 receptor antagonist (1994) (15)
Relaxation of heart muscle by catecholamines and by dibutyryl cyclic adenosine 3′,5′-monophosphate (1977) (15)
The beta 1-adrenoceptor antagonist CGP 20712 A unmasks beta 2-adrenoceptors activated by (-)-adrenaline in rat sinoatrial node. (1986) (15)
(--)-Timolol is a more potent antagonist of the positive inotropic effects of (--)-adrenaline than of those of (--)-noradrenaline in human atrium. (1996) (15)
Optical isomers of verapamil on canine heart (1975) (15)
Improved evaluation of binding of ligands to membranes containing several receptor-subtypes (1985) (14)
Relations between β-adrenoceptor occupancy and increases of contractile force and adenylate cyclase activity induced by catecholamines in human ventricular myocardium (2004) (14)
Allosteric properties of 5-HT2 receptors in tracheal smooth muscle (1986) (14)
Inhibition of sympathomimetic effects on the cardiovascular system by 4-(2-isopropylamino-1-hydroxyethyl)methanesulfonanilide hydrochloride (MJ 1999). (1967) (14)
Human heart Beta-adrenoceptors:-Beta1-adrenoceptor diversification through 'affinity states' and polymorphism (2006) (14)
Heart 5-HT Receptors. A Novel 5-HT Receptor in Human Atrium (1990) (14)
Evidence that (+)-bupranolol interacts directly with myocardial β-adrenoceptors (1980) (13)
Differences between the third cardiac beta-adrenoceptor and the colonic beta 3-adrenoceptor in the rat. (1996) (13)
Regional differences of β1- and β2-adrenoceptor-mediated functions in feline heart (1991) (13)
Stimulant and depressant effects ofβ-adrenoceptor blocking agents on isolated heart muscle (1980) (13)
Catecholamines relax portal and mesenteric veins from normal and portal hypertensive rats. (1989) (13)
The atypical cardiostimulant beta-adrenoceptor is distinct from beta-adrenoceptors and coupled to a cyclic AMP-dependent pathway in human and rat myocardium (1997) (13)
Sensitization of human atrial 5-HT4 receptors by chronic beta-blocker treatment. (1995) (13)
Carvedilol blocks h 2 - more than h 1 -adrenoceptors in human heart (2006) (13)
Aspartate138 is required for the high-affinity ligand binding site but not for the low-affinity binding site of the β1-adrenoceptor (2004) (12)
Physiological antagonism between ventricular beta 1-adrenoceptors and alpha 1-adrenoceptors but no evidence for beta 2- and beta 3-adrenoceptor function in murine heart. (2002) (12)
Direct labelling of β2-adrenoceptors (1986) (12)
The function of alpha- and beta-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice. (2007) (12)
5-Hydroxytryptamine-induced contraction of human temporal arteries coexpressing 5-HT2A receptors and wild-type or variant (Phe124Cys) 5-HT1B receptors: increased contribution of 5-HT1B receptors to the total contractile amplitude in arteries from Phe124Cys heterozygous individuals (2006) (11)
Xamoterol activates beta 1- but not beta 2-adrenoceptors in mammalian myocardium: comparison of its affinity for beta 1- and beta 2-adrenoceptors coupled to the adenylate cyclase in feline and human ventricle with positive inotropic effects. (1989) (11)
Function of cardiac beta1- and beta2-adrenoceptors of newborn piglets: role of phosphodiesterases PDE3 and PDE4. (2010) (11)
BIBN4096BS and CGRP8-37 antagonize the relaxant effects of α-CGRP more than those of β-CGRP in human extracranial arteries (2005) (11)
Activation of myocardial β-adrenoceptors by the nitrogen-free low affinity ligand 3′,4′-dihydroxy-α-methylpropiophenone (U-0521) (1977) (11)
Ketanserin causes surmountable antagonism of 5-hydroxytryptamine-induced contractions of large coronary arteries of dog (2004) (11)
Indazole as an indole bioisostere: 5-HT4 receptor antagonism. (1992) (10)
Is there a third heart beta-adrenoceptor? (1989) (10)
Allosteric properties of the 5-HT2 receptor system of the rat tail artery (1987) (10)
Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium (2014) (10)
Apparent equilibrium constant between β-adrenoceptors and a competitive antagonist on a cultured pacemaker cell of mammalian heart (1975) (10)
Sumatriptan contracts large coronary arteries of beagle dogs through 5-HT1-like receptors (1992) (10)
Dimethylation of the activator ICI 169,369 results in a high-affinity partial deactivator, ICI 170,809, of the arterial 5-hydroxytryptamine2 receptor system. (1989) (10)
Both beta 1- and beta 2-adrenoceptors mediate catecholamine-evoked arrhythmias in isolated human right atrium. (1993) (10)
Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta 3-adrenoceptor and rodent intestinal beta 3-adrenoceptors. (1997) (10)
Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation (2020) (9)
Effects of tryptamine mediated through 2 states of the 5-HT2 receptor in calf coronary artery (1988) (9)
Allosteric modulation of arterial 5-HT2 receptors (1990) (9)
Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium. (2002) (9)
The Affinity of Carazolol for Myocardial and Tracheal β-Adrenoceptors Activated by (−)-Isoprenaline (1978) (9)
Studies on the intrinsic activity (efficacy) of human adrenergic receptors. Co-expression of beta 1 and beta 2 reveals a lower efficacy for the beta 1 receptor. (1994) (9)
Fading of 5‐HT4 receptor‐mediated inotropic responses to 5‐hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium (2006) (9)
Role of urothelium on beta-3-adrenoceptor mediated relaxation in human detrusor muscle (2009) (8)
Inhibition of the sodium pump by cardioactive DPI 201‐106 (1987) (8)
Action potential shortening through the putative beta4-adrenoceptor in ferret ventricle: comparison with beta1- and beta2-adrenoceptor-mediated effects. (1998) (8)
Normalization of force to muscle cross‐sectional area: A helpful attempt to reduce data scattering in contractility studies? (2018) (8)
Direct labelling of myocardial β1-adrenoceptors (2004) (8)
Beta-adrenoceptor subtypes in human coronary artery: desensitization of beta 2-adrenergic vasorelaxation by chronic beta 1-adrenergic stimulation in vitro. (1995) (8)
Proceedings: Adrenergic receptors in heart muscle: similarity of apparent affinities of beta-blockers for receptors mediating adenyl-cyclase activity, inotropic and chronotropic effects of catecholamines. (1973) (8)
Different steric characteristics of beta 1- and beta 2-adrenoceptors. (1984) (8)
Evidence that (+)-bupranolol interacts directly with myocardial beta-adrenoceptors. Control of optical purity with differential thermal analysis. (1980) (7)
Neuronally released (−)-noradrenaline relaxes smooth muscle of calf trachea mainly through β1-adrenoceptors : comparison with (−)-adrenaline and relation to adenylate cyclase stimulation (2004) (7)
Mucosa of murine detrusor impairs β2‐adrenoceptor‐mediated relaxation (2015) (7)
Phosphodiesterase PDE2 activity, increased by isoprenaline, does not reduce β-adrenoceptor-mediated chronotropic and inotropic effects in rat heart (2018) (7)
Chronic β1-adrenoceptor blockade enhances positive inotropic responses to 5-hydroxytryptamine in human atrium (1990) (7)
Homology model and docking studies on porcine β2 adrenoceptor: description of two binding sites (2011) (7)
L-type calcium current and contractility in ventricular myocytes from mice overexpressing the cardiac beta 2-adrenoceptor. (1999) (7)
Reversible inhibition of potassium contractures by optical isomers of verapamil and D 600 on slow muscle fibres of the frog (2004) (7)
Contribution of beta 1- and beta 2-adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (-)-atenolol. (1988) (6)
Reflex inhibition of efferent renal sympathetic nerve activity by 5-hydroxytryptamine and nicotine is elicited by different epicardial receptors (1987) (6)
The affinity of atropine for muscarine receptors in human sphincter pupillae (1979) (6)
Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure (2005) (6)
Beta 1- and beta 2-adrenoceptor-mediated relaxation in human internal mammary artery and saphenous vein: unchanged beta- and alpha-adrenoceptor responsiveness after chronic beta 1-adrenoceptor blockade. (1993) (6)
Inhibitors of phosphodiesterases PDE2, PDE3, and PDE4 do not increase the sinoatrial tachycardia of noradrenaline and prostaglandin PGE1 in mice (2016) (6)
On criteria for functional beta 3-adrenoceptors. (1997) (6)
Simultaneous measurement of [3H]noradrenaline release and neurogenic contraction under identical conditions, to determine the prejunctional inhibitory effects of SKF 99101H and BRL 56905 in dog saphenous vein (1997) (6)
Interconversion into a low active state protects vascular 5-HT2-receptors against irreversible antagonism by phenoxybenzamine (1987) (6)
Contractile responses through Gs-coupled receptors are reduced by phosphodiesterase3 activity in human isolated myocardium (2006) (6)
Cultured heart cells as a model for beta-adrenoceptors in a heart pacemaker. Chronotropic spare beta-adrenoceptors and spare adenylyl cyclase for (-)-isoprenaline but not for (-)-dichloroisoprenaline in rat cardiocytes. (1982) (6)
Pertussis toxin suppresses carbachol-evoked cardiodepression but does not modify cardiostimulation mediated through beta1- and putative beta4-adrenoceptors in mouse left atria: no evidence for beta2- and beta3-adrenoreceptor function. (2000) (5)
No impact of sex and age on beta‐adrenoceptor‐mediated inotropy in human right atrial trabeculae (2020) (5)
Blockade of putative beta4- and beta1-adrenoceptors by carvedilol in ferret myocardium. (1999) (5)
Coexistence of Functioning f- and 32-Adrenoceptors in Single Myocytes From Human Ventricle (2005) (4)
EFFECT OF PYROGALLOL ON THE DURATION OF THE CARDIOVASCULAR ACTION OF CATECHOLAMINES. (1963) (4)
2780 – RELATIONSHIP BETWEEN THE CELLULAR NUMBER OF OCCUPIED β-ADRENOCEPTORS AND INOTROPIC EFFECTS OF CATECHOLAMINES IN HEARTS OF RESERPINE-PRETREATED KITTENS (1978) (4)
Direct labelling of myocardial β1-adrenoceptors (1986) (4)
Potentiation of responses to sympathetic nerve stimulation and vasoconstrictor agents by SK&F 103829 in the feline mesenteric circulation (1994) (4)
Simple O‐Acylated Derivatives of Lysergol and Dihydrolysergol‐I: Synthesis and Interaction with 5‐HT2A, 5‐HT2C and 5‐HT1B Receptors, and α1 Adrenergic Receptors (1999) (4)
Adenylyl cyclases: stimulation by hormones and regulation by nucleotides**Supported in part by grants from the US Public Health Service (HD-06513, HD-06273, HD-09581 and HD-07495) and from the Clayton Foundation. (1977) (4)
High affinity of carazolol for β-adrenoceptors coupled to the adenylyl cyclase in ventricular myocardium of kitten and xenopus laevis (1978) (4)
890 – PREVENTION OF VENTRICULAR FIBRILLATION BY CANINE CORONARY ARTERY LIGATION WITH OPTICAL ISOMERS OF VERAPAMIL (1977) (4)
Contribution of beta-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wildtype and beta(3)-adrenoceptor knockout mice. (2000) (4)
Improved evaluation of binding of ligands to membranes containing several receptor-subtypes (2004) (4)
Chronic activation of the low affinity site of β1‐adrenoceptors stimulates haemodynamics but exacerbates pressure‐overload cardiac remodelling (2013) (4)
(-)-CGP 12177-evoked cardiostimulation is abolished in double b1-/b2-adrenoceptor (AR) knockout mice. (2000) (4)
Studies on a novel selective beta(3)-adrenoceptor agonist in human right atrial appendage and human white adipocytes (1999) (4)
Influence of 4-(2-isopropylamino-1-hydroxyethyl) methanesulfonanilide (MJ 1999) on ventricular fibrillation induced by coronary occlusion. (1966) (3)
Activation of myocardial beta-adrenoceptors by the nitrogen-free low affinity ligand 3',4'-dihydroxy-alpha-methylpropiophenone (U-0521). (1977) (3)
Heart rate acceleration by imipramine and by noradrenaline after imipramine; its blockade by dichloroisoproterenol (DCL). (1962) (3)
On minimum cyclic AMP formation rates associated with positive inotropic effects mediated through beta 1-adrenoceptors in kitten myocardium. Beta 1-specific and non-adrenergic stimulant effects of denopamine. (2004) (3)
BIBN4096BS and CGRP(8-37) antagonize the relaxant effects of alpha-CGRP more than those of beta-CGRP in human extracranial arteries. (2005) (3)
E(cid:128)ects of ( (cid:55) )-RO363 at human atrial (cid:98) -adrenoceptor subtypes, the human cloned (cid:98) 3 -adrenoceptor and rodent intestinal (cid:98) 3 -adrenoceptors (1997) (3)
3 H-(-- )-Bupranolol , a New / 3-Adrenoceptor Radioligand : Characterization of Its Binding to Kitten Heart / 3-Adrenoceptors (3)
Adrenaline and noradrenaline increase contractile force of human ventricle through both beta 1- and beta 2-adrenoceptors. (1987) (3)
5-Hydroxytryptamine and the Human Heart (1991) (3)
Contribution of b-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wild-type and b3-adrenoceptor knockout mice: Involvement of the putative b4-adrenoceptor (1999) (3)
The function of α- and β-adrenoceptors in isolated heart muscle of man (1986) (3)
[Cardiac beta receptors--experimental aspects]. (1983) (3)
Transregulation of GS protein-coupled receptors by chronic ?-adrenoceptor blockade in human atrium (1989) (3)
SB 203186, A Potent 5-HT4 Antagonist for Cardiac 5-HT4 Receptors (1993) (2)
Effects of 6-hydroxydopamine on pre- and post-junctional 5-HT1-like receptor-mediated responses in dog saphenous vein (1993) (2)
Heart beta-receptors: on the functional role of heterogeneous binding sites. (1983) (2)
Beta4-adrenoceptors are more effective than beta1-adrenoceptors in mediating arrhythmic Ca2+ transients in mouse ventricular myocytes. (1999) (2)
Structure-basicity and structure-affinity relationships of beta-adrenergic blocking agents. (1975) (2)
A two-state model for the 5-HT2 receptor: effects of alpha-adrenoceptor ligands. (1988) (2)
Influence of lipophilicity and chirality on the selectivity of ligands for beta 1- and beta 2-adrenoceptors. (1988) (2)
Some aspects of heart beta adrenoceptor function (1991) (2)
Evidence against beta-3-adrenoceptor-mediated increases in contractile force and L-type Ca2+ current ICa-L in human atrial myocardium at 37 degrees C (2010) (2)
Inhibition of ventricular fibrillation induced by ouabain. (1966) (2)
[The effect of imipramine on the blood pressure and EKG effects of adrenalin, noradrenalin, hydroxytryptamine and hypertensin]. (1962) (1)
Pharmacological Observations on Vegetative Responses to Afferent Stimulation of the Vagus (1962) (1)
Both 1- and 2-adrenoceptors mediate increases in contractile force and hastening of relaxation in human atrium (2004) (1)
Surprises from a cardiac 5-HT4 TG mouse: spontaneous atrial arrhythmias by endogenous 5-HT of atrial origin? Different mechanism of arrhythmias through 5-HT4 receptors and β-adrenoceptors? (2013) (1)
571Cardiostimulant Effects of Mirabegron in Human Atrium and Ventricle In Vitro (2017) (1)
Phosphodiesterase PDE2 activity, increased by isoprenaline, does not reduce β-adrenoceptor-mediated chronotropic and inotropic effects in rat heart (2018) (1)
Cultured heart cells as a model for β-adrenoceptors in a heart pacemaker (1982) (1)
On Drug-Receptor Reaction Constants for Partial Agonists. Interaction with two Receptor Subtypes (1981) (1)
Pressor and electrocardiographic effects of epinephrine and norepinephrine in Leghorn chicken influenced by certain adrenergic blocking agents. (1963) (1)
Blocking action of desmethylimipramine (DMI) on the noradrenaline depletion by tyramine (1965) (1)
INFLUENCE OF DESMETHYLIMIPRAMINE ON THE PRESSOR RESPONSES TO ANGIOTENSIN. (1964) (1)
Arch & Kaumann 1993 part 2 of 3 (2015) (0)
Intrinsic sympathomimetic activity (ISA) of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta1-adrenoceptor in human right atrium (2003) (0)
607 INFLUENCE OF THE INTACT UROTHELIUM ON SS3-ADRENOCEPTOR MEDIATED RELAXATION IN HUMAN DETRUSOR (2009) (0)
Inhibitory action of desmethylimipramine on the restoration of the pressor effect of tyramine and on the uptake of noradrenaline in the reserpinized dog. (1966) (0)
The putative beta(4)-adrenoceptor activates the cyclic AMP pathway in human heart: Inhibition of positive inotropic responses by adenosine and carbachol (1998) (0)
Process for the preparation of tetrahydrokarbatsonijohdannaisten (1993) (0)
Cardiac Pacemaking The idea of Pollack (0)
Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium (2014) (0)
Carvedilol causes greater persistent blockage of beta2- than beta1-adrenoceptors in human failing myocardium (2005) (0)
Human heart beta1-adrenoceptor heterogeneity - diversification through 'affinity states' and polymorphism (2006) (0)
Tryptamine analogs, their synthesis and their use as 5-HT, -like or 5-HT 2 receptor agonists (1992) (0)
Coronary Heart Disease / Myocardial Infarction Variable Participation of 5-HIT 1-Like Receptors and 5-HT 2 Receptors in Serotonin-Induced Contraction of Human Isolated Coronary Arteries : 5-HTI-Like Receptors Resemble Cloned 5-HT 1 Dp Receptors (2005) (0)
(-)-Pindolol acts through two states of the beta(1)-adrenoceptor in human atrium and CHO cells. (2002) (0)
agonist tryptamine analogs, their production and application as 5-HT1-like receptors or 5-HT2 receptor (1992) (0)
Carvedilol blocks beta2-adrenoceptors more than beta1-adrenoceptors in human atrium (2005) (0)
Inhibitors of phosphodiesterases PDE2, PDE3, and PDE4 do not increase the sinoatrial tachycardia of noradrenaline and prostaglandin PGE1 in mice (2015) (0)
at two sites in recombinant human Ë 1 -adrenoceptors and interaction with Ë -blockers (2004) (0)
on the Intrinsic Activity (Efficacy) of Human Adrenergic Receptors Co-Expression of P, and P2 Reveals a Lower Efficacy for the 1 Receptor (0)
Sunday, 18 July 2010 (2010) (0)
Surprises from a cardiac 5-HT4 TG mouse: spontaneous atrial arrhythmias by endogenous 5-HT of atrial origin? Different mechanism of arrhythmias through 5-HT4 receptors and β-adrenoceptors? (2013) (0)
BETA ADRENERGIC BLOCKING EFFECT BY DCI IN THE LEGHORN CHICKEN. (1963) (0)
Condensed benzene derivatives with antagonistic activity 5-HT4 receptor, process for their preparation, compositions containing them and applications. (1992) (0)
3H-(-)-Bupranolol, a new beta-adrenoceptor radioligand: characterization of its binding to kitten heart beta-adrenoceptors. (1981) (0)
Human heart 5-HT receptors (1996) (0)
Selective j31-Adrenoceptor Blockade Enhances Positive Inotropic Responses toEndogenous Catecholamines Mediated Through j2-Adrenoceptors inHumanAtrial Myocardium (1990) (0)
198 Pharmacological Observations on the Responses to afferent stimulation of the vagus nerve (1961) (0)
(.+-.)-3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: A conformationally restricted analog of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor. [Erratum to document cited in CA119(11):117079z] (1993) (0)
L-type calcium current and contractility in ventricular myocytes from mice 1 overexpressing the cardiac b -adrenoceptor 2 (1999) (0)
Inotropic and arrhythmic effects of endothelin receptor agonists in human heart: Possible involvement of multiple receptors, L-type calcium channels and Gi-protein. (1998) (0)
Arch Kaumann 1993 beta 3 and atypical beta-adrenoceptors (2015) (0)
Piperidyl novel and aminoalkyl antagonist activity 5-HT4 receptor (1992) (0)
Pharmacological observations on the responses to afferent stimulation of the vagus (1962) (0)
Jr-and 32-adrenoceptor-mediated relaxation in human internal mammary artery and saphenous vein : unchanged fand a-adrenoceptor responsiveness after chronic 13-adrenoceptor blockade ' (2007) (0)
Condensed benzene derivatives with 5-HT4 receptor antagonistic activity, procedure for the preparation thereof, compositions which contain them, and applications (1992) (0)
antagonist 5-HT4 receptor (1992) (0)
(-)-[H-3]-CGP 12177 radiolabels beta(1)-, beta(2)- and putative beta(4)-adrenoceptors in human atrium and ventricle. (1998) (0)
Abstract 1182: Lack of Caveolae in Caveolin-1 Knock-out Mice Modulates Adrenoceptor-mediated Function in Small Arteries (2006) (0)
(-)-CGP12177 increases contractile force through beta1l-adrenoceptors but not through beta3-adrenoceptors in human right atrial myocardium (2009) (0)
b1-, b2- and putative b4-adrenoceptors (AR) in adult and infant human heart: selective coupling of b2-AR to Gs-protein. (2000) (0)

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