Alberto Kornblihtt
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Argentine biologist
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Alberto Kornblihtt's Degrees
- PhD Biological Sciences University of Buenos Aires
Why Is Alberto Kornblihtt Influential?
(Suggest an Edit or Addition)According to Wikipedia, Alberto Kornblihtt is an Argentine molecular biologist who specializes in alternative ribonucleic acid splicing. During his postdoctoral training with Francisco Baralle in Oxford, Kornblihtt documented one of the first cases of alternative splicing, explaining how a single transcribed gene can generate multiple protein variants. Kornblihtt was elected as a foreign associate of the National Academy of Sciences of the United States in 2011, received the Diamond Award for the most relevant scientist of Argentina of the decade, alongside physicist Juan Martin Maldacena, in 2013., and was incorporated to the Académie des Sciences of France in 2022.
Alberto Kornblihtt's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Epigenetics in Alternative Pre-mRNA Splicing (2011) (744)
- A slow RNA polymerase II affects alternative splicing in vivo. (2003) (704)
- Alternative splicing: multiple control mechanisms and involvement in human disease. (2002) (694)
- Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene. (1985) (578)
- Multiple links between transcription and splicing. (2004) (517)
- Alternative splicing: a pivotal step between eukaryotic transcription and translation (2013) (425)
- The connection between splicing and cancer (2006) (363)
- Functional association between promoter structure and transcript alternative splicing. (1997) (351)
- Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer. (1999) (339)
- Alternative splicing: a pivotal step between eukaryotic transcription and translation (2013) (330)
- Control of alternative splicing through siRNA-mediated transcriptional gene silencing (2009) (327)
- A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. (1993) (326)
- A methyl transferase links the circadian clock to the regulation of alternative splicing (2010) (277)
- Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing (2009) (270)
- Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT (2005) (250)
- Promoter usage and alternative splicing. (2005) (249)
- Regulation of alternative splicing through coupling with transcription and chromatin structure. (2015) (214)
- Transcriptional Activators Differ in Their Abilities to Control Alternative Splicing* (2002) (209)
- The fibronectin gene as a model for splicing and transcription studies (1996) (208)
- RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20 (2006) (205)
- Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains differing in the number of internal repeats. (1984) (186)
- How slow RNA polymerase II elongation favors alternative exon skipping. (2014) (185)
- Human fibronectin: molecular cloning evidence for two mRNA species differing by an internal segment coding for a structural domain. (1984) (181)
- Chromatin, transcript elongation and alternative splicing (2006) (173)
- A Chloroplast Retrograde Signal Regulates Nuclear Alternative Splicing (2014) (170)
- DNA Damage Regulates Alternative Splicing through Inhibition of RNA Polymerase II Elongation (2009) (168)
- Coupling transcription and alternative splicing. (2007) (163)
- DNA Damage Regulates Alternative Splicing through Inhibition of RNA Polymerase II Elongation (2009) (158)
- Antagonistic effects of T‐Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing (2001) (157)
- Isolation and characterization of cDNA clones for human and bovine fibronectins. (1983) (151)
- The carboxy terminal domain of RNA polymerase II and alternative splicing. (2010) (146)
- Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation (2002) (136)
- Progestins Induce Transcriptional Activation of Signal Transducer and Activator of Transcription 3 (Stat3) via a Jak- and Src-Dependent Mechanism in Breast Cancer Cells (2005) (132)
- Identification of a third region of cell-specific alternative splicing in human fibronectin mRNA. (1987) (120)
- First come, first served revisited: factors affecting the same alternative splicing event have different effects on the relative rates of intron removal. (2010) (114)
- Gene structure of human apolipoprotein A1. (1983) (102)
- The transcriptional cycle of HIV-1 in real-time and live cells (2007) (101)
- The transcriptional cycle of HIV-1 in real-time and live cells. (2007) (98)
- Promoter Architecture Modulates CFTR Exon 9 Skipping* (2003) (89)
- Transcriptional elongation and alternative splicing. (2013) (88)
- Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation (2013) (84)
- Heregulin Induces Transcriptional Activation of the Progesterone Receptor by a Mechanism That Requires Functional ErbB-2 and Mitogen-Activated Protein Kinase Activation in Breast Cancer Cells (2003) (84)
- Expression of a human alpha‐globin/fibronectin gene hybrid generates two mRNAs by alternative splicing. (1984) (83)
- Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells (2014) (80)
- Cyclic AMP inhibits fibronectin gene expression in a newly developed granulosa cell line by a mechanism that suppresses cAMP-responsive element-dependent transcriptional activation. (1990) (73)
- The role of fibronectins in embryonic cell migrations. (1988) (68)
- Mammary Epithelial-Mesenchymal Interaction Regulates Fibronectin Alternative Splicing via Phosphatidylinositol 3-Kinase* (2004) (66)
- When chromatin meets splicing (2009) (64)
- Alternative splicing switches: Important players in cell differentiation (2017) (64)
- A polar mechanism coordinates different regions of alternative splicing within a single gene. (2005) (64)
- Light Regulates Plant Alternative Splicing through the Control of Transcriptional Elongation. (2019) (64)
- Coordination between transcription and pre‐mRNA processing (2001) (60)
- Influence of Polymerase II Processivity on Alternative Splicing Depends on Splice Site Strength* (2003) (59)
- Perturbation of Chromatin Structure Globally Affects Localization and Recruitment of Splicing Factors (2012) (56)
- Alternative Splicing of G9a Regulates Neuronal Differentiation. (2016) (55)
- The transcription factor FBI‐1 inhibits SAM68‐mediated BCL‐X alternative splicing and apoptosis (2014) (54)
- MOLECULAR BIOLOGY OF THE EXTRACELLULAR MATRIX PROTEINS (1988) (53)
- The CCAAT-binding Proteins CP1 and NF-I Cooperate with ATF-2 in the Transcription of the Fibronectin Gene* (1996) (53)
- Connections between chromatin signatures and splicing (2013) (53)
- Varying patterns of expression of insulin‐like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability (1996) (51)
- A chromatin code for alternative splicing involving a putative association between CTCF and HP1α proteins (2015) (50)
- Coupling between transcription and alternative splicing. (2013) (49)
- Interaction of the -170 cyclic AMP response element with the adjacent CCAAT box in the human fibronectin gene promoter. (1992) (49)
- Identification of the Cellular Targets of the Transcription Factor TCERG1 Reveals a Prevalent Role in mRNA Processing* (2008) (48)
- Control of Alternative Pre‐mRNA Splicing by RNA Pol II Elongation: Faster is Not Always Better (2003) (47)
- Let there be light: Regulation of gene expression in plants (2014) (46)
- How Are Short Exons Flanked by Long Introns Defined and Committed to Splicing? (2016) (46)
- Chromatin and alternative splicing. (2010) (42)
- Isolation and characterization of cDNA clones for human liver fibronectin (1985) (40)
- Major Roles for Pyrimidine Dimers, Nucleotide Excision Repair, and ATR in the Alternative Splicing Response to UV Irradiation. (2017) (38)
- A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes (2019) (37)
- Downregulation of fibronectin transcription in highly metastatic adenocarcinoma cells (1998) (35)
- RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing (2011) (35)
- Isolated Polycystic Liver Disease Not Linked to Polycystic Kidney Disease 1 and 2 (1999) (35)
- Cloning of a cdc2-related protein kinase from Trypanosoma cruzi that interacts with mammalian cyclins. (1998) (33)
- Novel processing in a mammalian nuclear 28S pre‐rRNA: tissue‐specific elimination of an ‘intron’ bearing a hidden break site (1999) (33)
- The RNA Response to DNA Damage. (2016) (33)
- Alternative splicing at the right time (2011) (29)
- A family of fibronectin mRNAs in human normal and transformed cells. (1986) (28)
- Cross-talk between Signaling Pathways Regulates Alternative Splicing (2005) (27)
- Fibronectin, the generation of multiple polypeptides from a single gene. (1986) (27)
- A yeast sterol carrier protein with fatty-acid and fatty-acyl-CoA binding activity. (2006) (27)
- Alternative splicing adds a new loop to the circadian clock (2011) (25)
- Intragenic chromatin modifications: A new layer in alternative splicing regulation (2010) (24)
- Regulation of fibronectin alternative splicing by a basement membrane‐like extracellular matrix (2002) (23)
- Manganese ion dependent adenylate cyclase activity in rat testes: purification and properties. (1981) (22)
- Human fibronectin is synthesized as a pre‐propolypeptide (1986) (21)
- Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells (1988) (19)
- Retroviral-like features in the monomer of the major satellite DNA from the South American rodents of the genus Ctenomys. (1993) (19)
- Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential. (2006) (19)
- CTCF: from insulators to alternative splicing regulation (2012) (18)
- An early ancestor in the evolution of splicing: a Trypanosoma cruzi serine-arginine-rich protein (TcSR) is functional in cis-splicing. (2003) (17)
- Generation of full-length cDNA recombinant vectors for the transient expression of human fibronectin in mammalian cell lines. (1991) (17)
- Alternative Splicing and Transcription Elongation in Plants (2019) (17)
- A splicing regulator promotes transcriptional elongation (2008) (16)
- Interaction between the −170 CRE and the −150 CCAAT box is necessary for efficient activation of the fibronectin gene promoter by cAMP and ATF‐2 (1999) (16)
- Histone methylation, alternative splicing and neuronal differentiation (2016) (15)
- Regulation of fibronectin splicing in sinusoidal endothelial cells from normal or injured liver (2004) (15)
- Reconstitution of a hormone-sensitive adenylate cyclase with membrane extracts from Neurospora and avian erythrocytes. (1983) (15)
- Progesterone receptor induces bcl-x expression through intragenic binding sites favoring RNA polymerase II elongation (2013) (15)
- The physiology of alternative splicing (2022) (14)
- Genetic heterogeneity of autosomal dominant polycystic kidney disease in Argentina. (1997) (13)
- Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases. (2003) (13)
- Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy (2022) (12)
- Linking transcription, RNA polymerase II elongation and alternative splicing. (2020) (12)
- Epigenetics at the base of alternative splicing changes that promote colorectal cancer. (2017) (12)
- The Histone Methyltransferase G9a Controls Axon Growth by Targeting the RhoA Signaling Pathway. (2020) (12)
- Soluble adenylate cyclase activity in Neurospora crassa. (1982) (12)
- Binding of nuclear factors to a satellite DNA of retroviral origin with marked differences in copy number among species of the rodent Ctenomys. (1994) (12)
- Evidence for a role of the alternatively spliced ED-I sequence of fibronectin during ovarian follicular development. (1999) (12)
- Gene Silencing: Small RNAs Control RNA Polymerase II Elongation (2010) (12)
- Effects of airborne particulate matter on alternative pre-mRNA splicing in colon cancer cells. (2015) (11)
- A long noncoding way to alternative splicing in plant development. (2014) (11)
- mRNA Encoding a Putative RNA Helicase of the DEAD-Box Gene Family is Up-Regulated in Trypomastigotes of Trypanosoma cruzi (2000) (10)
- Shedding light on the chloroplast as a remote control of nuclear gene expression (2014) (10)
- Long range chromatin organization (2014) (10)
- DNA sequencing by the chemical method: a 10 minute procedure for the G+A reaction. (1993) (9)
- Inverse correlation between fibronectin mRNA levels and the metastatic potential of two murine mammary adenocarcinomas. (1991) (8)
- Transcriptional control of alternative splicing along time: Ideas change, experiments remain (2015) (8)
- Evidence for a Role of the Alternatively Spliced ED-I Sequence of Fibronectin during Ovarian Follicular Development. (1999) (8)
- GSK-3 is an RNA polymerase II phospho-CTD kinase (2020) (8)
- Seeking the truth behind the myth: Argonaute tales from “nuclearland” (2021) (7)
- Characterization of specific cDNA background synthesis introduced by reverse transcription in RT-PCR assays. (2010) (7)
- Shortcuts to the end (2004) (7)
- Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation (2015) (6)
- Long range chromatin organization: a new layer in splicing regulation? (2014) (6)
- Reciprocal regulation between alternative splicing and the DNA damage response (2020) (6)
- Fibronectin transcription in liver cells: promoter occupation and function in sinusoidal endothelial cells and hepatocytes. (2002) (5)
- Playing inside the genes (2009) (4)
- Nuclear role for human Argonaute-1 as an estrogen-dependent transcription coactivator (2020) (4)
- Where science and nonsense collide (2017) (4)
- A DNA intercalating dye-based RT-qPCR alternative to diagnose SARS-CoV-2 (2020) (4)
- A novel frameshift mutation (2436insT) produces an immediate stop codon in the autosomal dominant polycystic kidney disease 2 (PKD2) gene. (2000) (3)
- Régulation cinétique de l’épissage alternatif des pré-ARN messagers : attention au ralentissement (2014) (3)
- Interplay Between Chromatin and Splicing (2017) (3)
- [Kinetic regulation of pre-messenger RNA alternative splicing]. (2014) (2)
- [Autosomal dominant polycystic kidney disease: detection of a new mutation in the PKD1 gene]. (1999) (2)
- Beyond transcription: compelling open questions in plant RNA biology. (2022) (1)
- Analysis of fibronectin mRNAs in human normal and transformed cells (1986) (1)
- A new layer in splicing regulation (2014) (1)
- Why I testified in the Argentina abortion debate (2018) (1)
- A bumpy road for RNA polymerase II (2015) (1)
- Slow transcriptional elongation causes embryonic lethality and perturbs kinetic coupling of long neural genes (2018) (1)
- A Conversation with Alberto Kornblihtt. (2019) (0)
- The medial olivocochlear system and protection from acoustic trauma Ana Belén Elgoyhen 14 Mechanistic and functional insights into various cellular DNA transactions (2012) (0)
- University of Dundee Perturbation of Chromatin Structure Globally Affects Localization and Recruitment of Splicing Factors Schor, (2012) (0)
- Frontmatter (1984) (0)
- The fibronectin gene as a model for transcription and splicing studies (1996) (0)
- Three recent reports identify the roles of specific ribonucleases necessary for efficient termination of transcription by RNA polymerase II. In one case, the primary cleavage event is carried out by a ribozyme encoded in the pre-mRNA itself. (2004) (0)
- [Role of different forms of fibronectin in in vitro bovine follicular development]. (1997) (0)
- Table of Contents (1984) (0)
- Nuclear roles for Argonaute proteins in the control of flowering (2021) (0)
- Editorial Board (2009) (0)
- Towards a combined therapy for spinal muscular atrophy based on opposing effects of an antisense oligonucleotide on chromatin and splicing (2021) (0)
- Inhibition of cyclic 3′5′ monophosphate synthesis in rat testis by L-triiodothyronine (1981) (0)
- Issue Information (2020) (0)
- Cloning of a cdc 2-related protein kinase from Trypanosoma cruzi that interacts with mammalian cyclins 1 (1998) (0)
- Genetic heterogeneity ofautosomal dominant polycystic kidney disease inArgentina (1997) (0)
- [Alternative splicing and the cure of spinal muscular atrophy]. (2019) (0)
- Explorer The pathology of pre-mRNA splicing (2018) (0)
- Coupled Promoter Splicing Systems (2012) (0)
- Organelle Remote Control of Alternative Splicing Through TOR (2018) (0)
- A chromatin code for alternative splicing involving a putative association between CTCF and HP1α proteins (2015) (0)
- Prevalent Role in mRNA Processing Transcription Factor TCERG 1 Reveals a Identification of the Cellular Targets of the RNA : Processing and Catalysis (2008) (0)
- Introducing Transcription (2010) (0)
- Association of triiodothyronine binding activity to soluble adenylate cyclase in testicular preparations (1981) (0)
- Humanfibronectin: cell specific alterntve mRNAsplicing generates poWpeptide chalins differing in thenumber ofinternal repeats (1984) (0)
- 46. Peter Dolphin Memorial Symposium Lipoproteins and Cell Interactions (2003) (0)
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