Aleksander Koj | Academic Influence

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Aleksander Koj

Philosophy

#10241

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#14016

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#7169

World Rank

#8839

Historical Rank

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Philosophy

Aleksander Koj's Degrees

Doctorate Medicine Medical University of Warsaw
PhD Medical Sciences Medical University of Warsaw

Why Is Aleksander Koj Influential?

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According to Wikipedia, Aleksander Koj was a Polish physician and scientist, a member of Polish Academy of Learning and Polish Academy of Sciences, honorary doctor of Cleveland University and University of Hartford. He was a rector of Jagiellonian University for three cadences: 1987–1990, 1993–1996 and 1996–1999.

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Aleksander Koj's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Acute-Phase Reactants (1974) (358)
Initiation of acute phase response and synthesis of cytokines. (1996) (345)
Human keratinocytes and monocytes release factors which regulate the synthesis of major acute phase plasma proteins in hepatic cells from man, rat, and mouse. (1984) (196)
The Role of Interleukin‐6 as the Hepatocyte Stimulating Factor in the Network of Inflammatory Cytokines a (1989) (153)
Interleukin‐1‐inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL‐1β mRNA (2009) (144)
The acute-phase response of cultured rat hepatocytes. System characterization and the effect of human cytokines. (1984) (144)
Understanding local Mediterranean diets: a multidisciplinary pharmacological and ethnobotanical approach. (2005) (126)
Identification of the interleukin-6/oncostatin M response element in the rat tissue inhibitor of metalloproteinases-1 (TIMP-1) promoter. (1995) (119)
Regulatory feedback loop between NF‐κB and MCP‐1‐induced protein 1 RNase (2009) (96)
Termination of acute-phase response: role of some cytokines and anti-inflammatory drugs. (1998) (85)
Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) is a novel multifunctional modulator of inflammatory reactions. (2012) (83)
Changes in the blood level and affinity to concanavalin A of rat plasma glycoproteins during acute inflammation and hepatoma growth. (1982) (76)
Synthesis of antithrombin III and alpha-1-antitrypsin by the perfused rat liver. (1978) (74)
Subcellular distribution and intramitochondrial localization of three sulfurtransferases in rat liver (1975) (72)
The Acute-phase response to injury and infection : the roles of interleukin 1 and other mediators (1985) (68)
Identification of interleukin-1 and interleukin-6-responsive genes in human monocyte-derived macrophages using microarrays. (2008) (67)
Effect of endotoxin on plasma albumin and fibrinogen synthesis rates in rabbits as measured by the [14C] carbonate method. (1968) (65)
ISOTOPIC STUDIES OF UREA METABOLISM IN RABBITS. (1965) (64)
Synthesis of tissue inhibitor of metalloproteinase‐1 (TIMP‐1) in human hepatoma cells (HepG2) Up‐regulation by interleukin‐6 and transforming growth factor β1 (1992) (61)
Limited effects of recombinant human and murine interleukin 1 and tumour necrosis factor on production of acute phase proteins by cultured rat hepatocytes. (1987) (60)
[35S]thiosulphate oxidation by rat liver mitochondria in the presence of glutathione. (1967) (59)
Elimination of asialofetuin and asialoorosomucoid by the intact rat. Quantitative aspects of the hepatic clearance mechanism. (1978) (58)
Subcellular compartmentation of rhodanese and 3-mercaptopyruvate sulphurtransferase in the liver of some vertebrate species (1980) (47)
Mechanism of plasminogen activator inhibitor‐1 regulation by oncostatin M and interleukin‐1 in human astrocytes (2002) (45)
Short-term measurement of catabolic rates using iodine-labeled plasma protein. (1970) (43)
Divergent transforming growth factor-beta effects on IL-6 regulation of acute phase plasma proteins in rat hepatoma cells. (1993) (41)
Isolation and partial characterization of rabbit plasma alpha1-antitrypsin. (1978) (39)
Effects of interleukin-6 and leukemia inhibitory factor on the acute phase response and DNA synthesis in cultured rat hepatocytes. (1991) (38)
Inhibitory effect of di-catechol rooperol on VCAM-1 and iNOS expression in cytokine-stimulated endothelium. (1996) (34)
THE MEASUREMENT OF SYNTHESIS RATES OF ALBUMIN AND FIBRINOGEN IN RABBITS. (1965) (32)
Isolation and some molecular parameters of elastase-like normal proteinases from horse blood leucocytes. (1976) (31)
The measurement of absolute and relative synthesis rates of fibrinogen in vivo. (1968) (30)
Transcription factors as targets of the anti-inflammatory treatment. A cell culture study with extracts from some Mediterranean diet plants. (2005) (30)
Regulation of synthesis of some proteinase inhibitors in human hepatoma cells HepG2 by cytokines, hepatocyte growth factor and retinoic acid. (1993) (30)
Epidermal growth factor and pro-inflammatory cytokines regulate the expression of components of plasminogen activation system in U373-MG astrocytoma cells. (2001) (29)
The cascade of inflammatory cytokines regulating synthesis of acute phase proteins. (1988) (29)
Taurine in Human Blood Platelets (1959) (28)
Distinction between binding and endocytosis of human asialo-transferrin by the rat liver. (1978) (28)
Cytokines regulating acute inflammation and synthesis of acute phase proteins (1985) (27)
Regulatory mechanisms of gene expression: complexity with elements of deterministic chaos. (2006) (26)
The occurrence of common inhibitors of trypsin and of leucocyte neutral proteinase in human serum. (1972) (26)
Different preparations of natural and recombinant human interleukin-6 (IFN-beta 2, BSF-2) similarly stimulate acute phase protein synthesis and uptake of alpha-aminoisobutyric acid by cultured rat hepatocytes. (1989) (25)
Regulation of expression of stromyelysin-1 by proinflammatory cytokines in mouse brain astrocytes. (2003) (25)
A simple bioassay for monocyte-derived hepatocyte stimulating factor: increased synthesis of alpha 2-macroglobulin and reduced synthesis of albumin by cultured rat hepatocytes. (1985) (25)
Effect of experimental inflammation on the synthesis and distribution of antithrombin III and alpha1-antitrypsin in rabbits. (1978) (24)
Proteasome inhibitor MG-132 induces MCPIP1 expression (2013) (23)
Insulin cooperates with IL-1 in regulating expression of alpha 1-acid glycoprotein gene in rat hepatoma cells. (1994) (23)
Epidermal growth factor and transforming growth factor-β differently modulate the acute phase response elicited by interleukin-6 in cultured liver cells from man, rat and mouse (1990) (22)
Identification of changes in the transcriptome profile of human hepatoma HepG2 cells stimulated with interleukin-1 beta. (2004) (21)
The activity of cysteine desulphhydrase and rhodanase in animal tissues. (1962) (21)
Synthesis of α1‐microglobulin in cultured rat hepatocytes is stimulated by interleukin‐6, leukemia inhibitory factor, dexamethasone and retinoic acid (1992) (21)
Enzymic reduction of thiosulphate in preparations from beef liver. (1968) (21)
Cytokine production in human and rat macrophages and dicatechol rooperol and esters. (1996) (20)
Metabolic studies of acute-phase proteins (1984) (20)
Proteinase inhibitors as acute phase reactants: regulation of synthesis and turnover. (1988) (19)
Complex analysis of genes involved in the inflammatory response: interleukin-1-induced differential transcriptome of cultured human hepatoma HepG2 cells. (2003) (18)
Hepatocyte growth factor and retinoic acid exert opposite effects on synthesis of type 1 and type 2 acute phase proteins in rat hepatoma cells. (1995) (18)
A search for genes modulated by interleukin-6 alone or with interleukin-1beta in HepG2 cells using differential display analysis. (2006) (17)
Mimitin – a novel cytokine-regulated mitochondrial protein (2009) (17)
On the hormonal modulation of acute-phase plasma protein synthesis in perfused rat liver. (1974) (17)
Molecular cloning and expression of an intracellular serpin: an elastase inhibitor from horse leucocytes. (1993) (16)
Inhibitory effect of human recombinant interferon gamma on synthesis of acute phase proteins in human hepatoma Hep G2 cells stimulated by leukocyte cytokines, TNF alpha and IFN-beta 2/BSF-2/IL-6. (1988) (15)
Long-term culture of HepG2 hepatoma cells as a model for liver acute phase response during chronic inflammation. Effects of interleukin-6, dexamethasone and retinoic acid. (1994) (15)
Diacytosis of human asialotransferrin type 3 in the rat liver is due to the sequential engagement of two receptors. (1985) (15)
Biosynthesis and secretion of α1 acute‐phase globulin in primary cultures of rat hepatcytes (1985) (14)
Transforming growth factor‐β and epidermal growth factor modulate basal and interleukin‐6‐induced amino acid uptake and acute phase protein synthesis in cultured rat hepatocytes (1990) (14)
Substrate specificity and modifications of the active centre of elastase-like neutral proteinases from horse blood leucocytes. (1976) (14)
Regulatory Mechanisms Controlling Inflammation and Synthesis of Acute Phase Proteins (2011) (14)
Expression of a biologically active murine tissue inhibitor of metalloproteinases-1 (TIMP-1) in baculovirus-infected insect cells. Purification and tissue distribution in the rat. (1995) (14)
Differential responses of hematopoietic and non-hematopoietic cells to anti-inflammatory cytokines: IL-4, IL-13 and IL-10. (2000) (13)
Mitochondrial and cytosolic activities of three sulphurtransferases in some rat tissues and Morris hepatomas. (1977) (13)
Vaccinia virus-regulated acute phase cytokine production in human fibroblasts, U937 cells and endothelium. (1998) (12)
Rat contrapsins are the type II acute phase proteins: regulation by interleukin 6 on the mRNA level. (1994) (12)
Role of cytokines and growth factors in the induced synthesis of proteinase inhibitors belonging to acute phase proteins. (1991) (12)
Changes in the rates of synthesis of certain plasma proteins following tissue damage due to talc injection. A study using the perfused rat liver. (1968) (11)
Identification of major cellular proteins synthesized in response to interleukin-1 and interleukin-6 in human hepatoma HepG2 cells. (2006) (11)
Oxidation of thiosulphate to sulphate in animal tissues. (1967) (11)
Chromatography of heparin on sepharose-lysine: molecular size fractionation and its relevance to thrombin and antithrombin III binding. (1979) (11)
Synthesis and turnover of acute-phase reactants. In: Energy metabolism in trauma. (2008) (11)
Rooperol, an inhibitor of cytokine synthesis, decreases the respiratory burst in human and rat leukocytes and macrophages (1997) (10)
Acute-phase reactants and lysosomal enzymes in the blood of rats with experimental inflammation or radiation injury. (1970) (10)
Biosynthesis of glutathione in human blood cells. (1962) (10)
Ontogeny and tissue distribution of alpha-1-antitrypsin of the mouse. (1981) (10)
Modulation of acute phase protein synthesis in cultured rat hepatocytes by human recombinant hepatocyte growth factor. (1992) (9)
Plasma albumin loss due to bronchopathy. (1965) (9)
Origin of circulating acute phase cytokines: modified proteins may trigger IL-6 production by macrophages. Preliminary report. (1994) (9)
IL-1-mediated inhibition of IL-6-induced STAT3 activation is modulated by IL-4, MAP kinase inhibitors and redox state of HepG2 cells. (2002) (9)
Comparison of the acute phase response of cultured Morris hepatoma 7777 cells and of rat hepatocytes. (1987) (8)
Distribution of transaminases in human blood cells. (1960) (8)
Similarity of some molecular and catalytic parameters of mitochondrial and cytosolic mercaptopyruvate sulphurtransferase from rat liver. (1977) (8)
Comparison of synthesis and secretion of plasma albumin, fibrinogen and alpha 2-macroglobulin by slices of Morris hepatomas and rat liver. (1980) (7)
Inhibition of the liver and plasma protein acute-phase response in mice by D-galactosamine. (1976) (7)
Amino acid composition of rabbit plasma albumin and fibrin. (1969) (7)
Cytokines regulate plasminogen activation system in astrocytoma cells. (2002) (7)
Protective effect of rhodanese on the respiration of isolated mitochondria intoxicated with cyanide. (1975) (6)
Modified Proteins as Possible Signals in the Acute Phase Response a (1995) (6)
Rooperol tetraacetate decreases cytokine mRNA levels and binding capacity of transcription factors in U937 cells. (1998) (6)
Acute phase response to recombinant interleukin‐6 and macrophage‐ and fibroblast‐derived crude cytokine preparations in primary cultures of mouse hepatocytes (1989) (5)
Proteinase inhibitors from horse plasma and leucocytes: properties and biological functions. (1986) (5)
Differential effects of oncostatin M and leukaemia inhibitory factor expression in astrocytoma cells. (2001) (5)
From the Obscure and Mysterious Acute Phase Response to Toll-Like Receptors and the Cytokine Network (2008) (5)
Synthesis and secretion of some plasma proteins by tissue slices of Morris hepatoma 7777 and liver from control and turpentine-injected rats. (1983) (5)
Comparison of the Action of Interleukin‐6, Phorbol Myristate Acetate, and Glucagon on the Acute Phase Protein Production and Amino Acid Uptake by Cultured Rat Hepatocytes (1989) (4)
Subcellular Compartmentation and Biological Functions of Mercaptopyruvate Sulphurtransferase and Rhodanese (1980) (4)
Synthesis of alpha 1-microglobulin in cultured rat hepatocytes is stimulated by interleukin-6, leukemia inhibitory factor, dexamethasone and retinoic acid. (1992) (4)
The effect of D-galactosamine on plasma protein synthesis by the perfused rat liver from turpentine-stimulated donors. (1978) (4)
Comparison of some physicochemical properties of rat and beef liver rhodanese. (1979) (3)
AMMONIA NITROGEN AND PROTEIN SYNTHESIS (1967) (3)
Vaccinia virus‐induced changes in cytokine‐regulated acute phase plasma protein synthesis by hepatoma cells (1998) (3)
ISolation of rat α-fetoprotein from morris hepatoma 7777 (1982) (3)
An alternative regulatory pathway of the acute phase response: the role of fibroblast-derived interferon-β 2 (1988) (3)
Interferon-gamma regulates alpha 2-macroglobulin and alpha 1-antichymotrypsin expression on the pretranslational level in HepG2 cells. (1992) (3)
Kinetics and stoichiometry of inactivation of some pancreatic and leucocyte serine proteinases by rabbit alpha 1-proteinase inhibitors F and S. (1983) (3)
Comparison of antiproteolytic activities of alpha-1-proteinase inhibitors from the plasma of some mammalian species. (1986) (3)
CYSTEINE DESULFHYDRASE AND RHODANASE ACTIVITY IN CELLS OF TISSUE CULTURES AND IN TRANSPLANTABLE TUMORS. (1964) (2)
Effects of dexamethasone and insulin on the acute phase response of Morris hepatoma cells and of rat hepatocytes in culture. (1988) (2)
Studies on the inhibition of HeLa cell growth by proteins from the granular fraction of rat liver. (1972) (2)
On the contents and importance of methionine in rabbit alpha 1-proteinase inhibitors F and S. (1985) (2)
Inhibition of horse leucocyte proteinases by eglin, a proteinase inhibitor from leeches. (1985) (2)
Alpha-1-acute phase globulin in the blood of tunicamycin-injected rats. Isolation of the non-glycosylated form, its inhibitory properties and synthesis in liver slices. (1986) (2)
Synthesis and turnover of prothrombin during experimental inflammation in rats. (1984) (2)
Transforming growth factor-beta and epidermal growth factor modulate basal and interleukin-6-induced amino acid uptake and acute phase protein synthesis in cultured rat hepatocytes. (1990) (2)
Ethionine-dependent inhibition of acute-phase plasma protein synthesis in the rat. (1983) (2)
The effects of heterologous antisera to soluble proteins from horse leucocyte granules and rat liver mitochondrial-lysosomal fraction on the activity of some lysosomal hydrolases in vitro. (1974) (2)
Synthesis and catabolism of rabbit alpha 1-antitrypsins F and S. (1980) (2)
Epidermal growth factor and transforming growth factor-beta differently modulate the acute phase response elicited by interleukin-6 in cultured liver cells from man, rat and mouse. (1990) (2)
Simultaneous isolation and partial characterization of antithrombin III and alpha 1-proteinase inhibitor from horse plasma. (1982) (2)
Comparison of specificity of human and horse leucocyte proteinases with synthetic peptide substrates. (1986) (2)
[Effect of erythrocytes on respiration of human leukocytes]. (1958) (1)
Effects of agents labilizing lysosomes on concentrations of "acute-phase" proteins in rabbit plasma. (1969) (1)
Modulation of acute phase protein synthesis by cellular growth and differentiation factors. (1992) (1)
Interaction of horse plasma antithrombin III and alpha 1-proteinase inhibitor with some serine proteinases. (1981) (1)
Images of the World: Science, Humanities, Art (2001) (1)
Effects of HGF and RA on the Class 1 and Class 2 Rat Acute Phase Proteins a (1995) (1)
[Mechanism of thiosulfate oxidation in animal tissues]. (1969) (1)
Some immunochemical properties of bovine and rat rhodanese. (1980) (1)
[Congenital nonspherocytic hemolytic anemia with deficiency of glucose-6-phosphate dehydrogenase]. (1966) (1)
[Nocturnal paroxysmal hemoglobinuria. Studies on the mechanism of hemolysis]. (1962) (1)
EFFECT OF THIOL COMPOUNDS ON SULPHAEMOGLOBIN FORMATION. (1964) (1)
MULTIPLE FORMS OF RABBIT ALPHA-1-ANTITRYPSIN AND DIFFERENTIAL INACTIVATION OF SOME SERINE PROTEINASES (1981) (1)
SYNTHESIS AND SECRETION OF ACUTE-PHASE RAT PLASMA GLYCOPROTEINS BY SLICES OF MORRIS HEPATOMA 7777 (1981) (0)
Changes of Paradigms in the Life Sciences (2007) (0)
[Application of the specific sorption method (affinity chromatography to isolation of enzymes and enzyme inhibitors]. (1972) (0)
BMC Cell Biology Mimitin – a novel cytokine-regulated mitochondrial protein (2015) (0)
Isolation of rat alpha-fetoprotein from Morris hepatoma 7777. (1982) (0)
COMPARISON OF SYNTHESIS AND SECRETION OF PLASMA ALBUMIN, FIBRINOGEN AND a2-MACROGLOBULIN BY SLICES OF MORRIS HEPATOMAS AND RAT LIVER (2007) (0)
[Molecular mechanisms of the acute phase reaction and innate immunological response]. (2010) (0)
Interaction of serum proteins and proteins from leucocyte lysosomes. (1972) (0)
Biosynthesis and secretion of alpha 1 acute-phase globulin in primary cultures of rat hepatocytes. (1985) (0)
Changes of Paradigms in Biology and Medicine (1995) (0)
Differential effects of antibodies to rat liver tritosome proteins on the activity of some lysosomal hydrolases in vitro. (1975) (0)
O 1 . 2 Loss of the tumor suppressor CYLD causes enhanced NF-kappaB and Wnt / β-catenin signaling in multiple myeloma (2011) (0)
[Glutathione metabolism and neuraminic acid content of the erythrocytes in a case of nocturnal paroxysmal hemoglobinuria]. (1962) (0)
Differential inhibition of serine proteinases by rabbit alpha 1-proteinase inhibitors F and S. (1981) (0)
EFFECT OF EXPERIMENTAL INFLAMMATION ON THE SYNTHESIS AND DISTRIBUTION OF ANTITHROMBIN III AND a1-ANTITRYPSIN IN RABBITS (2007) (0)
The Influence of Human Blood Cells on the Solubility of Clot in Urea Solution and Clot Lysis (1966) (0)
[Alpha-1-antitrypsin of blood serum: its biochemical properties, inborn deficiencies and biological functions]. (1972) (0)
[Hormonal regulation of protein synthesis of the acute phase]. (1974) (0)
Plasma proteinase inhibitors in Morris hepatoma-bearing rats: changes in the blood level and synthesis in tissue slices. (1985) (0)
Author Index of Volume 67 (1993) (0)
[Letter to the editor of Przeglad Lekarski: Historical aspects of the acute- phase reaction]. (2010) (0)
DIFFERENTIAL INHIBITION OF SERINE PROTEINASES BY RABBIT α 1-PROTEINASE INHIBITORS F AND S (2009) (0)
[Biological role of leucocytic proteases and their significance to clinical medicine (author's transl)]. (1974) (0)
[Glutathione and neuraminic acid of erythrocytes in paroxysmal nocturnal haemoglobinuria]. (1962) (0)
[Report of the 8th Congress of the European Federation of Biochemical Societies (FEBS) in Amsterdam]. (1973) (0)
[Protein bronchorrhea]. (1966) (0)
[Neutral protease from horse blood granulocytes (author's transl)]. (1974) (0)
Disorders in the metabolism of erythrocytes in a case of congenital nonspherocytic hemolytic anemia with glucose-6-phosphate dehydrogenase deficiency. (1966) (0)
[The Cartesian diver method in investigation of metabolism of the cells]. (1960) (0)
3 Regulatory Mechanisms Controlling Inflammation and Synthesis of Acute Phase Proteins (2017) (0)
Isolation and Some Properties of Horse Leucocyte Neutral Proteases (1977) (0)
Methionine in rabbit alpha 1-proteinase inhibitors. (1983) (0)
Preface (1995) (0)
Biological Perspectives of Cytokine and Hormone Networks (2020) (0)
Studies on the inhibition of HeLa cell growth by proteins from the granular fraction of rat liver. (1972) (0)
[Pneumotachographic studies in pneumoconiosis, pulmonary emphysema and bronchitis]. (1962) (0)
[METHODS OF MEASUREMENT OF PLASMA PROTEINS SYNTHESIS IN VIVO]. (1964) (0)
[Studies on the mechanism of the appearance of sulfhemoglobinemia]. (1962) (0)
[Metabolism of plasma albumin in the light of isotopic investigations]. (1966) (0)
Mechanisms of the Ontogenesis of Living Creatures (2008) (0)
[Immunological identification of serum proteins forming complexes with proteins of leukocyte granules]. (1972) (0)
[Mechanisms regulating enzyme activity in the cell and in the organism]. (1971) (0)
[Investigations on the solubility in urea of blood clots from patients with chronic myeloid leukemia]. (1965) (0)

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