Aleksandra Filipovska
#113,167
Most Influential Person Now
Australian scientist
Aleksandra Filipovska's AcademicInfluence.com Rankings
Aleksandra Filipovskabiology Degrees
Biology
#7026
World Rank
#9872
Historical Rank
Biotechnology
#298
World Rank
#300
Historical Rank
Biochemistry
#2517
World Rank
#2678
Historical Rank
Aleksandra Filipovskaengineering Degrees
Engineering
#8659
World Rank
#10248
Historical Rank
Biomedical Engineering
#876
World Rank
#892
Historical Rank
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Biology Engineering
Aleksandra Filipovska's Degrees
- PhD Biomedical Engineering University of Melbourne
- Bachelors Biochemistry University of Melbourne
Why Is Aleksandra Filipovska Influential?
(Suggest an Edit or Addition)According to Wikipedia, Aleksandra Filipovska is a Professor, Deputy Director of the ARC Centre of Excellence in Synthetic Biology and NHMRC Senior Research Fellow at the University of Western Australia, heading a research group at the Telethon Kids Institute. Specializing in biochemistry and molecular biology, she has made contributions to the understanding of human mitochondrial genetics in health and disease.
Aleksandra Filipovska's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Human Mitochondrial Transcriptome (2011) (646)
- Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols. (2008) (448)
- Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology (2005) (408)
- Gold compounds as therapeutic agents for human diseases. (2011) (369)
- Long noncoding RNAs are generated from the mitochondrial genome and regulated by nuclear-encoded proteins. (2011) (235)
- RNA processing in human mitochondria (2011) (218)
- Glutathionylation of mitochondrial proteins. (2005) (186)
- Complex I within Oxidatively Stressed Bovine Heart Mitochondria Is Glutathionylated on Cys-531 and Cys-704 of the 75-kDa Subunit (2008) (174)
- A gold(I) phosphine complex selectively induces apoptosis in breast cancer cells: implications for anticancer therapeutics targeted to mitochondria. (2007) (159)
- A universal code for RNA recognition by PUF proteins. (2011) (157)
- Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals (2017) (136)
- Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation (2012) (136)
- Pentatricopeptide repeat domain protein 3 associates with the mitochondrial small ribosomal subunit and regulates translation (2009) (108)
- Mitochondria‐Targeted Antioxidants in the Treatment of Disease (2008) (108)
- Synthesis and Characterization of a Triphenylphosphonium-conjugated Peroxidase Mimetic (2005) (106)
- Conserved and Novel Functions for Arabidopsis thaliana MIA40 in Assembly of Proteins in Mitochondria and Peroxisomes (2010) (106)
- The human mitochondrial transcriptome and the RNA‐binding proteins that regulate its expression (2012) (99)
- Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly. (2016) (93)
- Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors. (2011) (92)
- POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA (2016) (87)
- Pentatricopeptide repeat domain protein 1 lowers the levels of mitochondrial leucine tRNAs in cells (2009) (86)
- Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers. (2004) (86)
- SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation (2015) (79)
- Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM (2018) (75)
- Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies (2016) (75)
- CirGO: an alternative circular way of visualising gene ontology terms (2019) (72)
- Modular recognition of nucleic acids by PUF, TALE and PPR proteins. (2012) (71)
- Disulphide formation on mitochondrial protein thiols. (2005) (69)
- Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome. (2017) (68)
- Rescue of skeletal muscle α-actin–null mice by cardiac (fetal) α-actin (2009) (67)
- Bioenergetic differences selectively sensitize tumorigenic liver progenitor cells to a new gold(I) compound. (2008) (65)
- The role of mammalian PPR domain proteins in the regulation of mitochondrial gene expression. (2012) (64)
- LRPPRC-mediated folding of the mitochondrial transcriptome (2017) (63)
- Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice (2016) (63)
- The Design of Gold-Based, Mitochondria-Targeted Chemotherapeutics (2008) (57)
- Specialization from synthesis: How ribosome diversity can customize protein function (2013) (55)
- Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation (2004) (54)
- MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins (2012) (53)
- Ca(v)1.2 calcium channel is glutathionylated during oxidative stress in guinea pig and ischemic human heart. (2011) (53)
- An artificial PPR scaffold for programmable RNA recognition (2014) (52)
- Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences. (2003) (50)
- Gold(I) chloride adducts of 1,3-bis(di-2-pyridylphosphino)propane: synthesis, structural studies and antitumour activity. (2007) (50)
- Organelle transcriptomes: products of a deconstructed genome. (2013) (50)
- L-type Ca(2+) channel contributes to alterations in mitochondrial calcium handling in the mdx ventricular myocyte. (2013) (49)
- Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria (2018) (48)
- Concerted regulation of mitochondrial and nuclear non‐coding RNAs by a dual‐targeted RNase Z (2018) (47)
- Designer RNA-binding proteins: New tools for manipulating the transcriptome (2011) (46)
- Engineered rRNA enhances the efficiency of selenocysteine incorporation during translation. (2013) (44)
- Impaired functional communication between the L-type calcium channel and mitochondria contributes to metabolic inhibition in the mdx heart (2014) (42)
- Transcriptome-wide effects of a POLR3A gene mutation in patients with an unusual phenotype of striatal involvement. (2016) (39)
- TEFM regulates both transcription elongation and RNA processing in mitochondria (2019) (37)
- PTCD1 Is Required for 16S rRNA Maturation Complex Stability and Mitochondrial Ribosome Assembly. (2018) (37)
- Estrogen-mediated regulation of mitochondrial gene expression. (2015) (36)
- Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network (2018) (36)
- Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice (2015) (36)
- Pentatricopeptide repeats (2013) (35)
- Mutation in MRPS34 Compromises Protein Synthesis and Causes Mitochondrial Dysfunction (2015) (35)
- Mapping of mitochondrial RNA-protein interactions by digital RNase footprinting. (2013) (35)
- Modulation of miRNA function by natural and synthetic RNA-binding proteins in cancer (2019) (33)
- Fidelity of translation initiation is required for coordinated respiratory complex assembly (2019) (33)
- Adult-onset obesity is triggered by impaired mitochondrial gene expression (2017) (33)
- Building a Parallel Metabolism within the Cell. (2008) (32)
- Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies. (2016) (30)
- Simultaneous processing and degradation of mitochondrial RNAs revealed by circularized RNA sequencing (2017) (29)
- 1 : 2 Adducts of copper(I) halides with 1,2-bis(di-2-pyridylphosphino)ethane: solid state and solution structural studies and antitumour activity. (2009) (27)
- Mitochondrial respiratory states and rates (2019) (25)
- Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome. (2018) (23)
- The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication (2021) (23)
- Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction (2018) (23)
- Dinuclear Au(i) N-heterocyclic carbene complexes derived from unsymmetrical azolium cyclophane salts: potential probes for live cell imaging applications. (2016) (21)
- Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping. (2013) (19)
- A bifunctional protein regulates mitochondrial protein synthesis (2014) (19)
- Supernumerary proteins of mitochondrial ribosomes. (2014) (19)
- Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria (2019) (18)
- Promoter polymorphisms in two overlapping 6p25 genes implicate mitochondrial proteins in cognitive deficit in schizophrenia (2012) (18)
- Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL‐6 production (2018) (18)
- Stepwise maturation of the peptidyl transferase region of human mitoribosomes (2021) (18)
- The L‐type Ca2+ channel facilitates abnormal metabolic activity in the cTnI‐G203S mouse model of hypertrophic cardiomyopathy (2016) (18)
- Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation (2019) (17)
- Erratum: Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome (The American Journal of Human Genetics (2017) 101(2) (239–254) (S0002929717302835) (10.1016/j.ajhg.2017.07.005)) (2018) (17)
- Founder p.Arg 446* mutation in the PDHX gene explains over half of cases with congenital lactic acidosis in Roma children. (2014) (16)
- Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins (2018) (14)
- A mutation in MT-TW causes a tRNA processing defect and reduced mitochondrial function in a family with Leigh syndrome. (2015) (14)
- Organization and expression of the mammalian mitochondrial genome (2022) (14)
- The Role of the L-Type Ca2+ Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy (2016) (14)
- Is mitochondrial gene expression coordinated or stochastic? (2018) (13)
- Cardiolipin is required for membrane docking of mitochondrial ribosomes and protein synthesis (2020) (13)
- Analysis of the human mitochondrial transcriptome using directional deep sequencing and parallel analysis of RNA ends. (2014) (13)
- Mitochondria: Unusual features of the mammalian mitoribosome. (2014) (11)
- The FASTK family proteins fine-tune mitochondrial RNA processing (2021) (11)
- Expression patterns of regulatory RNAs, including lncRNAs and tRNAs, during postnatal growth of normal and dystrophic (mdx) mouse muscles, and their response to taurine treatment. (2018) (9)
- Defects in RNA metabolism in mitochondrial disease. (2017) (8)
- Severe Isolated Growth Hormone Deficiency and Myopathy in Two Brothers With RNPC3 Mutation (2015) (8)
- Regulation of a minimal transcriptome by repeat domain proteins. (2017) (8)
- An Artificial Yeast Genetic Circuit Enables Deep Mutational Scanning of an Antimicrobial Resistance Protein. (2018) (8)
- Review of Machine Learning Algorithms in Differential Expression Analysis (2017) (6)
- Fidelity and coordination of mitochondrial protein synthesis in health and disease (2020) (6)
- Cardiolipin is required for membrane docking of mitochondrial ribosomes and protein synthesis. (2020) (6)
- Overview of Protein Glutathionylation (2006) (5)
- Manipulating and elucidating mitochondrial gene expression with engineered proteins (2019) (5)
- Tighter Ligand Binding Can Compensate for Impaired Stability of an RNA-Binding Protein. (2018) (4)
- Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan (2021) (4)
- Reduced mitochondrial translation prevents diet-induced metabolic dysfunction but not inflammation (2020) (4)
- Measurement of Protein Glutathionylation (2006) (3)
- OmicsVolcano: software for intuitive visualization and interactive exploration of high-throughput biological data (2021) (3)
- Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease (2022) (3)
- A modified yeast three-hybrid system enabling both positive and negative selections (2018) (3)
- Computationally designed hyperactive Cas9 enzymes (2022) (3)
- Preventative therapeutic approaches for hypertrophic cardiomyopathy (2020) (2)
- In silico evolution of nucleic acid-binding proteins from a nonfunctional scaffold (2022) (2)
- Tiny but Mighty: Expression of the Mitochondrial Genome (2013) (2)
- Author response: Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals (2017) (2)
- Circularized Visualisation of Genetic Interactions (2017) (2)
- Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion (2022) (1)
- Characterising Mitochondrial Morphology and Signalling in Familial Hypertrophic Cardiomyopathy (2017) (1)
- Mitochondrial respiratory states and rates: building blocks of mitochondrial physiology (2018) (1)
- Estrogen-mediated regulation of mitochondrial gene expression 1 (2014) (1)
- Building artificial genetic circuits to understand protein function. (2020) (1)
- Investigating Mitochondrial Transcriptomes and RNA Processing Using Circular RNA Sequencing. (2021) (1)
- Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease (2020) (1)
- A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance (2021) (1)
- Molecular basis of translation termination at noncanonical stop codons in human mitochondria (2023) (0)
- Multi-omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer. (2023) (0)
- LRPPRC-mediated folding of the mitochondrial transcriptome (2017) (0)
- A modified yeast three-hybrid system enabling both positive and negative selections (2018) (0)
- Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM (2018) (0)
- The role of an unconventional ribosomal protein in mitochondrial function (2013) (0)
- Multi-omics approach characterises CRLS1 deficiency, a novel mitochondrial disorder (2022) (0)
- Loss of Mitochondrial RNA Binding Protein PTCD1 Leads to Cardiomyopathy (2018) (0)
- Crystal structure of designed cPPR-NRE protein (2014) (0)
- Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins (2018) (0)
- State C of the human mitoribosomal large subunit assembly intermediate (2021) (0)
- The in vivo role of the mitochondrial DNA nuclease MGME1 (2017) (0)
- State A of the human mitoribosomal large subunit assembly intermediate (2021) (0)
- The Design of Gold‐Based, Mitochondria‐Targeted Chemotherapeutics (2009) (0)
- Chapter 4:Synthetic biology with RNA (2014) (0)
- Temporal landscape of mitochondrial proteostasis governed by the UPRmt (2022) (0)
- Crystal structure of designed (SeMet)-cPPR-NRE protein (2014) (0)
- Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria (2018) (0)
- Characterising l-Type Ca2+ Channel Function and Mitochondrial Function in the Cardiac Troponin I Mouse Model of Familial Hypertrophic Cardiomyopathy (2012) (0)
- CirGO: an alternative circular way of visualising gene ontology terms (2019) (0)
- Misregulation of Mitochondrial Protein Synthesis Leads to Cardiomyopathy (2019) (0)
- The First Mitochondrial Genomics and Evolution SMBE-Satellite Meeting: A New Scientific Symbiosis (2017) (0)
- Altered Communication Between the l-Type Ca2+ Channel and VDAC Contributes to Metabolic Inhibition in mdx Cardiomyopathy (2012) (0)
- Modulation of miRNA function by natural and synthetic RNA-binding proteins in cancer (2019) (0)
- Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation. (2023) (0)
- Frankenstein Cas9: engineering improved gene editing systems. (2022) (0)
- Defects in mitochondrial RNA metabolism in disease (2016) (0)
- Evidence for Altered Communication Between the L-Type Ca2+ Channel and Mitochondria in a Model of Cardiomyopathy (2012) (0)
- ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing (2022) (0)
- Crystal structure of mouse Taco1 (2016) (0)
- State B of the human mitoribosomal large subunit assembly intermediate (2021) (0)
- Shackled ribosomes unleashed (2022) (0)
- Crystal structure of designed cPPR-polyA protein (2014) (0)
- Mouse models of mitochondrial dysfunction (2015) (0)
- Pathogenic Variants in RNPC3 are Associated with Hypopituitarism and Primary Ovarian Insufficiency (2021) (0)
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What Schools Are Affiliated With Aleksandra Filipovska?
Aleksandra Filipovska is affiliated with the following schools:
