Alessio Ciulli
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Alessio Ciulli's AcademicInfluence.com Rankings
Alessio Ciullichemistry Degrees
Chemistry
#5055
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#6161
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Organic Chemistry
#928
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#1041
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Alessio Ciullibiology Degrees
Biology
#13858
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#17454
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Genetics
#1670
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#1778
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Molecular Biology
#2485
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#2524
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Biochemistry
#2556
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#2723
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Chemistry Biology
Alessio Ciulli's Degrees
- PhD Chemistry University of Florence
- Bachelors Chemistry University of Florence
Why Is Alessio Ciulli Influential?
(Suggest an Edit or Addition)According to Wikipedia, Alessio Ciulli is an Italian British biochemist. Currently, he is the Professor of Chemical & Structural Biology at the School of Life Sciences, University of Dundee, where he founded and directs Dundee' new Centre for Targeted Protein Degradation . He is also the scientific co-founder and advisor of Amphista Therapeutics.
Alessio Ciulli's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4 (2015) (597)
- Structural basis of PROTAC cooperative recognition for selective protein degradation (2017) (546)
- Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction (2012) (309)
- Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities (2014) (239)
- BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design (2019) (231)
- Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α. (2012) (175)
- Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7 (2018) (163)
- Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation (2017) (147)
- SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate (2019) (143)
- Dissecting fragment-based lead discovery at the von Hippel-Lindau protein:hypoxia inducible factor 1α protein-protein interface. (2012) (143)
- Targeting Cullin–RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation (2015) (139)
- Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition (2016) (134)
- Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. (2009) (128)
- Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds (2017) (125)
- Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery. (2011) (123)
- A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes (2014) (120)
- Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods. (2006) (119)
- Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders (2017) (111)
- Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein–Protein Interactions (2015) (110)
- Structure‐Based Design of a Macrocyclic PROTAC (2019) (110)
- Fragment-based approaches to enzyme inhibition. (2007) (102)
- Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery (2013) (99)
- E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones (2020) (91)
- Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain (2013) (88)
- Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex (2017) (78)
- Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrroli (2017) (78)
- Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121. (2012) (75)
- 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation (2018) (74)
- Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. (2019) (71)
- Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs (2019) (68)
- Bifunctional chemical probes inducing protein-protein interactions. (2019) (68)
- Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. (2010) (67)
- Salicylate Biosynthesis: Overexpression, Purification, and Characterization of Irp9, a Bifunctional Salicylate Synthase from Yersinia enterocolitica (2005) (67)
- Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies. (2017) (65)
- Biophysical screening for the discovery of small-molecule ligands. (2013) (63)
- Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader (2019) (57)
- Molecular Basis of Histone Tail Recognition by Human TIP5 PHD Finger and Bromodomain of the Chromatin Remodeling Complex NoRC (2015) (57)
- Inhibition of Mycobacterium tuberculosis Pantothenate Synthetase by Analogues of the Reaction Intermediate (2008) (55)
- Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader (2019) (54)
- Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity (2021) (54)
- NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes (2014) (53)
- Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein–Protein Interactions? (2013) (48)
- Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology (2016) (48)
- A Fragment‐Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry (2009) (44)
- Understanding and Improving the Membrane Permeability of VH032-Based PROTACs (2020) (41)
- New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease (2018) (37)
- New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition (2015) (36)
- Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity (2021) (36)
- Crystal Structure of Escherichia coli Ketopantoate Reductase in a Ternary Complex with NADP+ and Pantoate Bound (2007) (32)
- Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. (2011) (32)
- The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound. (2005) (31)
- Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening (2017) (26)
- Multimeric Complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: Insights into the Structure and Assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases (2013) (26)
- Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System (2020) (24)
- Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues. (2020) (24)
- Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis (2015) (23)
- Transforming targeted cancer therapy with PROTACs: A forward-looking perspective. (2021) (22)
- Brd4‐Brd2 isoform switching coordinates pluripotent exit and Smad2‐dependent lineage specification (2017) (22)
- Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains (2017) (22)
- Chemical genetics approaches for selective intervention in epigenetics (2016) (21)
- Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking. (2014) (20)
- Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach (2018) (19)
- Biophysical Studies on Interactions and Assembly of Full-size E 3 Ubiquitin Ligase SUPPRESSOR OF CYTOKINE SIGNALING 2 ( SOCS 2 )-ELONGIN BC-CULLIN 5-RING BOX PROTEIN 2 ( RBX 2 ) * (2015) (18)
- Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition† †Electronic supplementary information (ESI) available: Supplemental results (Fig. S1–S13 and Tables S1–S10). Crystallography data collection and refinement statistics. Experimental section. Detailed compound s (2018) (18)
- The biochemical properties of the two Arabidopsis thaliana isochorismate synthases (2017) (18)
- Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase (2018) (18)
- Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase (2018) (17)
- A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo (2022) (17)
- Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti‐tubercular agents using a fragment‐based drug design approach (2017) (16)
- Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements (2017) (16)
- Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins (2021) (16)
- Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to a Bacterial Amino-Sugar Acetyltransferase from Campylobacter jejuni. (2017) (16)
- Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory. (2022) (14)
- Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma (2021) (13)
- Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases (2015) (13)
- Target 2035 – update on the quest for a probe for every protein (2021) (13)
- RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response. (2019) (13)
- Ligand‐Observed NMR in Fragment‐Based Approaches (2012) (12)
- Biophysical Studies on Interactions and Assembly of Full-size E3 Ubiquitin Ligase (2014) (11)
- Coenzyme biosynthesis: enzyme mechanism, structure and inhibition. (2007) (11)
- Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2 (2022) (11)
- Spy vs. spy: selecting the best reporter for 19F NMR competition experiments† †Electronic supplementary information (ESI) available: Compound synthesis and characterization, experimental procedures for protein expression and biophysical experiments (raw data and fitting). See DOI: 10.1039/c8cc09790a (2019) (11)
- pH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study (2007) (10)
- Targeting epigenetic reader domains by chemical biology. (2020) (10)
- Wernicke's encephalopathy post subtotal extended gastrectomy. (1995) (10)
- Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders (2022) (10)
- Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis. (2005) (10)
- Mechanistic and Structural Features of PROTAC Ternary Complexes. (2021) (10)
- Expression and high yield production of the catalytic domain of matrix metalloproteinase 12 and of an active mutant with increased solubility (2003) (9)
- Transsternal approach to closure of bronchopleural fistulas after pneumonectomy. A fifteen cases report. (2000) (9)
- Protein degradation for drug discovery. (2019) (9)
- Nucleophile Selectivity of Chorismate‐Utilizing Enzymes (2007) (8)
- [Intestinal perforation caused by a chicken bone: apropos of a clinical case]. (1997) (8)
- Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders (2022) (8)
- Thioamide substitution to probe the hydroxyproline recognition of VHL ligands (2018) (8)
- Targeting Epigenetic Modulators Using PROTAC Degraders: Current Status and Future Perspective. (2022) (8)
- Biophysical characterization of laforin-carbohydrate interaction. (2016) (7)
- Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design (2019) (7)
- SPR-measuredkinetics of PROTAC ternary complexes influence target degradation rate (2018) (7)
- Intraoperative high-resolution ultrasonography in the localization of occult endocrine pancreatic tumours. (1983) (7)
- Structure‐Guided Design of Peptides as Tools to Probe the Protein–Protein Interaction between Cullin‐2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin Ligases (2017) (6)
- Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues (2020) (5)
- opnMe.com: a digital initiative for sharing tools with the biomedical research community (2022) (5)
- Intraoperative high-resolution hepatosonography in the detection of occult metastases in colorectal carcinoma. (1983) (5)
- Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand (2017) (5)
- New class of molecule targets proteins outside cells for degradation (2020) (5)
- Abstract A179: The BRD4 degrader MZ1 exhibits potent antitumoral activity in diffuse large B cell lymphoma of the activated B cell-like type (2018) (5)
- Trivalent PROTACs enhance protein degradation through cooperativity and avidity (2020) (5)
- Translating PROTAC chemical series optimization into functional outcomes underlying BRD7 and BRD9 protein degradation (2021) (5)
- Correction to “3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation” (2019) (4)
- Fragment-based drug discovery in academia: Experiences from a tuberculosis programme (2009) (4)
- Von Hippel–Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein (2021) (4)
- A beginner’s guide to PROTACs and targeted protein degradation (2021) (4)
- [Acute ischemia of the lower limbs]. (1996) (4)
- Chapter 16:Discovery and Extrapolation of Fragment Structures towards Drug Design (2007) (3)
- Effects of meta-substitution on aggregation in the cubanes [SnNR]4{R = [2-Me-5-MeOC6H3], [2,5-(MeO)2C6H3] and [3,5-(MeO)2C6H3]} (2002) (3)
- Heritability of variation in glycaemic response to metformin (2014) (3)
- Heparin induced thrombocytopenia after low molecular weight heparin treatment: a case report. (1996) (3)
- Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor (2019) (3)
- The PROTAC MZ1 in complex with the second bromodomain of Brd4 and pVHL:ElonginC:ElonginB (2017) (3)
- Automated Determination of Nuclear Magnetic Resonance Chemical Shift Perturbations in Ligand Screening Experiments: The PICASSO Web Server (2021) (2)
- Crystal structure of macrocyclic PROTAC 1 in complex with the second bromodomain of human Brd4 and pVHL:ElonginC:ElonginB (2019) (2)
- MST and TRIC Technology to Reliably Study PROTAC Binary and Ternary Binding in Drug Development. (2021) (2)
- Crystal structure of PROTAC 1 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB (2019) (2)
- University of Dundee Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau ( VHL ) E 3 ubiquitin ligase and the hypoxia inducible factor ( HIF ) alpha subunit with in vitro nanomolar affinities (2014) (2)
- Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay. (2021) (2)
- Surgical treatment of T3 lung cancer invading the chest wall. (1999) (2)
- Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB (2019) (2)
- Functional genomic analysis of epithelioid sarcoma reveals distinct proximal and distal subtype biology (2022) (2)
- Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB (2019) (2)
- The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like type (2021) (2)
- PO-449 Optimisation of an AlphaLISA assay for the characterisation of PROTAC-induced ternary complexes within cell lysates (2018) (2)
- Crystal structure of pantothenate synthetase in complex with 2-(2-(benzofuran-2-ylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acid (2009) (1)
- Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms (2022) (1)
- DUB be good to me (2022) (1)
- Chapter 2. Structural and Biophysical Principles of Degrader Ternary Complexes (2020) (1)
- Inducible Degradation of Target Proteins Through a Tractable Affinity-Directed PROtein Missile (AdPROM) System (2020) (1)
- Stereoselective synthesis of allele-specific BET inhibitors. (2020) (1)
- Crystal structure of ketopantoate reductase in complex with NADP (2005) (1)
- Pantothenate synthetase in complex with racemate (2S)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID and (2R)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID (2013) (0)
- Crystal structure of HsaD bound to 3,5-dichloro-4-hydroxybenzenesulphonic acid (2017) (0)
- Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation (2017) (0)
- Crystal structure of human BAZ2A PHD zinc finger in the free form (2014) (0)
- Structure-based PROTAC design demonstrates BAF complex ATPase vulnerabilities in cancer (2019) (0)
- pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-3,3-dimethylbutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 15) (2014) (0)
- Escherichia coli ketopantoate reductase in complex with 2-monophosphoadenosine-5'-diphosphate (2006) (0)
- [Evaluation of the operative risk in transduodenal papillostomy]. (1982) (0)
- 1 Title : Structural basis of PROTAC cooperative recognition for selective protein 1 degradation 2 (2017) (0)
- Targeted Protein Degradation with Small Molecules: How PROTACs Work (2019) (0)
- University of Dundee Selective small molecule induced degradation of the BET bromodomain protein BRD 4 (2015) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution in a ternary complex with fragment compounds 5-methoxyindole and 1-benzofuran-2-carboxylic acid (2009) (0)
- Review for "Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12" (2020) (0)
- pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-3,3-dimethyl-2-(oxetane-3-carboxamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 19) (2017) (0)
- Human Brd2(BD2) L383V mutant in complex with ET-JQ1-OMe (2020) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.80 Ang resolution in complex with 5'-deoxy-5'-thioadenosine (2009) (0)
- VHL inhibitor binding increases intracellular level of VHL (2021) (0)
- Crystal structure of the bromodomain of human SMARCA2 in complex with SMARCA-BD ligand (2019) (0)
- pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-thioxopropan-2-yl)acetamide (ligand 4) (2018) (0)
- pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(cyclobutanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 18) (2017) (0)
- pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(1-acetamidocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 17) (2017) (0)
- Structure of cytochrome CYP121 in complex with 2-methylquinolin-6-amine (2012) (0)
- Crystal structure of BRD2(BD2) W370F mutant with ligand 28 bound (2015) (0)
- pVHL54-213-EloB-EloC complex (4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-N-[4-(1,3-OXAZOL-5-YL)BENZYL]-L-PROLINAMIDE bound (2012) (0)
- Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide (2019) (0)
- pVHL:EloB:EloC in complex with (2S,4R)-4-hydroxy-1-((S)-2-(2-hydroxyacetamido)-3,3-dimethylbutanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 3) (2017) (0)
- Coenzyme Biosynthesis: Enzyme Mechanism, Structure and Inhibition (2008) (0)
- Discovery of Benzo[d]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain (2022) (0)
- VHL ligand binding increases intracellular level of VHL (2021) (0)
- An intramolecular bivalent degrader glues an intrinsic BRD4-DCAF16 interaction (2023) (0)
- Structure of CYP121 in complex with 4-(4-phenoxy-1H-pyrazol-3-yl)benzene-1,3-diol (2012) (0)
- Structure of cytochrome P450 CYP121 in complex with 4-(1H-1,2,4-triazol-1-yl)phenol (2012) (0)
- Human Brd2(BD2) mutant in free form (2018) (0)
- [Intra-operative echographic exploration of the hepatobiliopancreatic system]. (1989) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.95 Ang resolution in complex with 5'-deoxy-5'-((R)-3,4-dihydroxybutylthio)-adenosine (2009) (0)
- pVHL:EloB:EloC in complex with modified VH032 containing (3R,4S)-3-fluoro-4-hydroxyproline (ligand 14a) (2018) (0)
- Ankyrin repeat and SOCS-box protein 9 (ASB9) in complex with ElonginB and ElonginC (2013) (0)
- Type II dehydroquinase from Mycobacterium Tuberculosis complexed with 3-dehydroshikimate (2010) (0)
- Structure of P450 CYP121 in complex with lead compound MB286, 3-((1H-1,2,4-triazol-1-yl)methyl)aniline (2012) (0)
- Crystal structure of 3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with inhibitor 2 (2011) (0)
- Surgical treatment of digestive arteries aneurysms. (1997) (0)
- pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(thiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 4) (2014) (0)
- pVHL:EloB:EloC in complex with VH298 (2016) (0)
- EXPRESSION, PURIFICATION AND CRYSTALLIZATION OF EPIGENETIC READER OF THE NUCLEOSOME: THE PHD ZINC FINGER DOMAIN OF BAZ1A (2014) (0)
- Crystal structure of BRD2(BD2) mutant with ligand ME bound (METHYL (2R)- 2-[(4S)-6-(4-CHLOROPHENYL)-8-METHOXY-1-METHYL-4H-[1,2,4]TRIAZOLO[4,3-A][1, 4]BENZODIAZEPIN-4-YL]PROPANOATE) (2014) (0)
- pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-Acetamidopropanethioyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl) benzyl)pyrrolidine-2-carboxamide (ligand 3) (2018) (0)
- University of Dundee BRD 4-BRD 2 isoform switching coordinates pluripotent exit and Smad 2-dependent lineage specification (2017) (0)
- Structure of cytochrome P450 CYP121 in complex with 4-oxo-4,5,6,7-tetrahydrobenzofuran-3-carboxylate (2012) (0)
- von Hippel-Lindau protein-ElonginB-ElonginC complex, bound to Hif1- alpha peptide (2012) (0)
- Crystal structure of BAZ2A PHD zinc finger in complex with H3 3-mer peptide (2018) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.75 Ang resolution in complex with 5'-deoxy-5'-((3-nitrobenzyl)disulfanyl)-adenosine (2009) (0)
- Structure of SOCS2:Elongin C:Elongin B from DMSO-treated crystals (2015) (0)
- Crystal structure of BAZ2A PHD zinc finger in complex with H3 10-mer AA mutant peptide (2018) (0)
- Wales Andrew Wheatley Paul Wood Peter Wothers Dominic Wright An introduction to Cambridge Chemistry Academic staff (2012) (0)
- Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-Methoxy-N-(5-methylpyridin-2-ylsulfonyl)-1H-indole-2-carboxamide (2009) (0)
- pVHL-ELOB-ELOC complex_(2S,4R)-1-(3-amino-2-methylbenzoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide bound (2012) (0)
- pVHL:EloB:EloC in complex with methyl 4H-furo[3,2-b]pyrrole-5-carboxylate (2018) (0)
- pVHL:EloB:EloC complex, in complex with capped Hydroxyproline (2012) (0)
- Protein‐Based NMR Methods Applied to Drug Discovery (2017) (0)
- pVHL54-213-EloB-EloC complex _ methyl 4-(((2S,4R)-4-hydroxy-1-(2-(3- methylisoxazol-5-yl)acetyl)pyrrolidine-2-carboxamido)methyl)benzoate (2012) (0)
- Crystal structure of HsaD bound to 3,5-dichlorobenzene sulphonamide (2017) (0)
- pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(3-methyl-4-(thiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 6) (2014) (0)
- pVHL:EloB:EloC in complex with (2S,4R)-1-((2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carbonyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 10) (2014) (0)
- Crystal structure of BAZ2A PHD zinc finger in complex with Fr 19 (2018) (0)
- Crystallization of VHL-based PROTAC-induced ternary complexes. (2023) (0)
- von Hippel Lindau protein:ElonginB:ElonginC complex, in complex with (2S,4R)-N-methyl-1-[2-(3-methyl-1,2-oxazol-5-yl)ethanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide (2013) (0)
- Type II dehydroquinase from Mycobacterium tuberculosis complexed with citrazinic acid (2010) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.70 Angstrom resolution in complex with 2-(2-((benzofuran-2-carboxamido)methyl)-5-methoxy-1H-indol-1-yl)acetic acid (2010) (0)
- pVHL:EloB:EloC in complex with modified VH032 containing (3S,4S)-3-fluoro-4-hydroxyproline (ligand 14b) (2018) (0)
- SMARCA4 biology in alveolar rhabdomyosarcoma (2022) (0)
- Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in complex with fragment 1 (2013) (0)
- Crystal Structure of the bromodomain of human BAZ2B in complex with compound-1 N01197 (2013) (0)
- [Criteria for surgery of lithiasis of the common bile duct]. (1982) (0)
- Abstract 3849: Structure-based PROTAC design demonstrates BAF complex ATPase vulnerabilities in cancer (2019) (0)
- pVHL54-213-EloB-EloC complex _ (2S,4R)-N-((1,1'-biphenyl)-4-ylmethyl)- 4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)pyrrolidine-2- carboxamide (2012) (0)
- [Experience and results in low colo-rectal mechanical anastomosis in surgery of cancer of the rectum]. (1982) (0)
- Inside Cover: A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry (ChemBioChem 17/2009) (2009) (0)
- Crystal structure of BRD2(BD2) mutant W370F in the free form (2015) (0)
- THE ROLE OF EFFLUX PUMP INHIBITORS ON FIRST- AND SECOND-LINE ANTI-TUBERCULOSIS DRUGS IN RIFAMPICIN MONO- RESISTANT CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS (2015) (0)
- University of Dundee Cyclic and macrocyclic peptides as chemical tools to recognise protein surfaces and probe protein-protein interactions (2017) (0)
- pVHL-EloB-EloB-EloC complex_(2S,4R)-1-(2-chlorophenyl)carbonyl-N-[(4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound (2012) (0)
- HsaD bound to 3,5-dichloro-4-hydroxybenzoic acid (2017) (0)
- Front Cover: Discovery of Benzo[ d ]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain (ChemMedChem 20/2022) (2022) (0)
- pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 7) (2014) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.6 Ang resolution in complex with fragment compound 5-methoxyindole, sulfate and glycerol (2009) (0)
- The 2nd Alpine Winter Conference on Medicinal and Synthetic Chemistry (2021) (0)
- Crystal structure of human BAZ2B PHD zinc finger in complex with Fr 21 (2018) (0)
- pVHL54-213-EloB-EloC complex_apo (2012) (0)
- Ube2T in complex with fragment EM04 (2017) (0)
- Crystal structure of human BAZ2A PHD zinc finger in complex with unmodified H3K4 histone peptide (2014) (0)
- Editorial overview: Hot targets and new modalities. (2021) (0)
- pVHL54-213-EloB-EloC complex_(2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol- 5-yl)acetyl)-N-(4-nitrobenzyl)pyrrolidine-2-carboxamide bound (2012) (0)
- von Hippel Lindau protein:ElonginB:ElonginC complex, in complex with (2S,4R)-1-ethanoyl-N-[[4-(1,3-oxazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide (2013) (0)
- pVHL:EloB:EloC in complex with modified HIF-1a CODD peptide containing (3R,4S)-3-fluoro-4-hydroxyproline (ligand 13a) (2018) (0)
- Crystal structure of SOCS2:Elongin C:Elongin B in complex with erythropoietin receptor peptide (2019) (0)
- Target validation: Switching domains. (2016) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.05 Ang resolution- in complex with sulphonamide inhibitor 3 (2008) (0)
- Correction: Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay (2021) (0)
- pVHL:EloB:EloC in complex with 6-chlorothiochroman-4-one (2018) (0)
- Crystal structure of the Zn-bound ubiquitin-conjugating enzyme Ube2T (2017) (0)
- Abstract IACICR01: Perspective on bivalent degraders (2021) (0)
- Effects of meta-substitution on aggregation in the cubanes (SnNR) 4 {R (2-Me-5-MeOC 6 H 3 ), (2,5-(MeO) 2 C 6 H 3 ) and (3,5-(MeO) 2 C 6 H 3 )} (2002) (0)
- Fragment-based approaches for anti-tuberculosis drug discovery (2013) (0)
- Breaking free from the crystal lattice: Structural biology in solution to study protein degraders. (2023) (0)
- Crystal structure of BRD2(BD2) mutant in free form (2014) (0)
- Pantothenate synthetase in complex with 1,3-DIMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2013) (0)
- Human Brd2(BD2) mutant in complex with 9-ME-Am1 (2018) (0)
- pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-acetamidopropanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl) pyrrolidine-2-carboxamide (ligand 11) (2017) (0)
- Building ubiquitination machineries (2020) (0)
- pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol (2018) (0)
- Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate (2007) (0)
- Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in a ternary complex with ATP and N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE (2013) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.5 Ang resolution- apo form (2008) (0)
- University of Dundee New synthetic routes to Triazolo-benzodiazepine analogues (2016) (0)
- Crystal structure of BRD2(BD2) W370F mutant with ligand I-BET 762 bound (2015) (0)
- as a comparative model for human (2019) (0)
- Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase (2019) (0)
- Pantothenate synthetase in complex with N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE (2013) (0)
- Crystal structure of human BAZ2A PHD zinc finger in complex with unmodified H3 10-mer (2017) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.40 Ang resolution in complex with fragment compound 1-Benzofuran-2-carboxylic acid (2009) (0)
- ketopantoate reductase: a structural and calorimetric study (2007) (0)
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