Alex Avdeef

Alex Avdeef's AcademicInfluence.com Rankings

Alex Avdeef

Chemistry

#4923

World Rank

#6017

Historical Rank

Organic Chemistry

#822

World Rank

#922

Historical Rank

chemistry Degrees

Alex Avdeef

Biology

#13415

World Rank

#16960

Historical Rank

Biochemistry

#2346

World Rank

#2495

Historical Rank

biology Degrees

Download Badge

Chemistry
Biology

Alex Avdeef's Degrees

PhD Biochemistry University of California, Berkeley
Masters Chemistry Stanford University
Bachelors Chemistry University of California, Berkeley

Why Is Alex Avdeef Influential?

(Suggest an Edit or Addition)

(See a Problem?)

Alex Avdeef's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Coexistence of passive and carrier-mediated processes in drug transport (2010) (525)
Absorption and Drug Development: Solubility, Permeability, and Charge State (2003) (491)
Physicochemical Profiling (Solubility, Permeability and Charge State) (2001) (340)
pH-Metric logP 10. Determination of Liposomal Membrane-Water Partition Coefficients of lonizable Drugs (1998) (339)
Absorption and drug development (2003) (252)
Solubility of sparingly-soluble ionizable drugs. (2007) (250)
Coordination chemistry of microbial iron transport compounds. 9. Stability constants for catechol models of enterobactin (1978) (250)
Absorption classification of oral drugs based on molecular surface properties. (2003) (233)
COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT COMPOUNDS. 19. STABILITY CONSTANTS AND ELECTROCHEMICAL BEHAVIOR OF FERRIC ENTEROBACTIN AND MODEL COMPLEXES (1979) (224)
pH-Metric Solubility. 2: Correlation Between the Acid-Base Titration and the Saturation Shake-Flask Solubility-pH Methods (2004) (218)
Classification Analysis of P-Glycoprotein Substrate Specificity (2003) (217)
pH-Metric log P. 3. Glass electrode calibration in methanol-water, applied to pKa determination of water-insoluble substances (1993) (213)
PH-metric log P 11. pKa determination of water-insoluble drugs in organic solvent-water mixtures. (1999) (204)
PAMPA--critical factors for better predictions of absorption. (2007) (199)
Physicochemical profiling (solubility, permeability and charge state). (2001) (196)
pH-metric log P. II: Refinement of partition coefficients and ionization constants of multiprotic substances. (1993) (192)
PAMPA--a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones. (2004) (181)
In vitro trans-monolayer permeability calculations: often forgotten assumptions. (2003) (175)
Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA method (2005) (172)
The rise of PAMPA (2005) (166)
Dissolution rate and apparent solubility of poorly soluble drugs in biorelevant dissolution media. (2010) (150)
pH‐Metric log P. Part 1. Difference Plots for Determining Ion‐Pair Octanol‐Water Partition Coefficients of Multiprotic Substances (1992) (148)
PAMPA--a drug absorption in vitro model 13. Chemical selectivity due to membrane hydrogen bonding: in combo comparisons of HDM-, DOPC-, and DS-PAMPA models. (2004) (148)
Skin-PAMPA: a new method for fast prediction of skin penetration. (2012) (143)
Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques (2002) (142)
PAMPA--a drug absorption in vitro model 11. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates. (2004) (142)
Potentiometric pKa determination of water-insoluble compounds: validation study in methanol/water mixtures (1997) (140)
Drug absorption in vitro model: filter-immobilized artificial membranes. 2. Studies of the permeability properties of lactones in Piper methysticum Forst. (2001) (137)
Interlaboratory study of log P determination by shake-flask and potentiometric methods. (1996) (131)
Accurate measurements of the concentration of hydrogen ions with a glass electrode: calibrations using the Prideaux and other universal buffer solutions and a computer-controlled automatic titrator (1978) (110)
Two isostructural actinide .pi. complexes. Crystal and molecular structure of bis(cyclooctatetraenyl)uranium(IV), U(C8H8)2, and bis(cyclooctatetraenyl)thorium(IV), Th(C8H8)2 (1972) (109)
Advances in screening for membrane permeability: high-resolution PAMPA for medicinal chemists. (2004) (106)
Evidence-based approach to assess passive diffusion and carrier-mediated drug transport. (2012) (105)
Miniaturized Rotating Disk Intrinsic Dissolution Rate Measurement: Effects of Buffer Capacity in Comparisons to Traditional Wood’s Apparatus (2008) (103)
pH-metric solubility. 3. Dissolution titration template method for solubility determination. (2001) (99)
Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition. (2014) (98)
PAMPA--a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa(flux)--optimized design (pOD-PAMPA). (2003) (92)
pH-metric log P. 4. Comparison of partition coefficients determined by HPLC and potentiometric methods to literature values. (1994) (92)
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? (2010) (88)
Calibration of copper ion selective electrode response to pCu 19 (1983) (88)
Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method. (2005) (84)
Octanol-, chloroform-, and propylene glycol dipelargonat-water partitioning of morphine-6-glucuronide and other related opiates. (1996) (82)
Structure-Lipophilicity Relationships of Neutral and Protonated β-Blockers, Part I, Intra- and Intermolecular Effects in Isotropic Solvent Systems (1999) (81)
Crystal and molecular structure of tris(2,4-pentanedionato)manganese(III), Mn(O2C5H7)3, a distorted complex as predicted by Jahn-Teller arguments (1974) (79)
Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion—Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model (2011) (78)
Determination of protonation macro- and microconstants and octanol/water partition coefficient of the antiinflammatory drug niflumic acid. (1994) (75)
PAMPA--a drug absorption in vitro model 8. Apparent filter porosity and the unstirred water layer. (2004) (75)
Equilibrium solubility measurement of ionizable drugs - consensus recommendations for improving data quality (2016) (75)
In Vitro Permeability of Poorly Aqueous Soluble Compounds Using Different Solubilizers in the PAMPA Assay with Liquid Chromatography/Mass Spectrometry Detection (2003) (74)
P-glycoprotein deficient mouse in situ blood-brain barrier permeability and its prediction using an in combo PAMPA model. (2009) (74)
Leakiness and Size Exclusion of Paracellular Channels in Cultured Epithelial Cell Monolayers–Interlaboratory Comparison (2010) (72)
Estimating the Water Solubilities of Crystalline Compounds from Their Chemical Structures Alone (2001) (67)
Powder Dissolution Method for Estimating Rotating Disk Intrinsic Dissolution Rates of Low Solubility Drugs (2009) (65)
Permeation of permanently positive charged molecules through artificial membranes--influence of physico-chemical properties. (2007) (65)
pH‐metric Solubility. 1. Solubility‐pH Profiles from Bjerrum Plots. Gibbs Buffer and pKa in the Solid State (1998) (63)
Dissolution and Solubility (2007) (57)
Solubility-Excipient Classification Gradient Maps (2007) (57)
High‐Throughput Measurements of Solubility Profiles (2007) (55)
PAMPA–Excipient Classification Gradient Map (2006) (54)
Studies of the cubane cluster of copper(I). A modified self-consistent charge and configuration molecular orbital investigation of the cluster containing the Cu8S124- core (1978) (52)
Membrane–Water partitioning, membrane permeability, and baseline toxicity of the parasiticides ivermectin, albendazole, and morantel (2008) (49)
The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability. (2010) (48)
Biorelevant pK(a) (37 °C) predicted from the 2D structure of the molecule and its pK(a) at 25 °C. (2011) (46)
Absorption-excipient-pH classification gradient maps: sparingly soluble drugs and the pH partition hypothesis. (2008) (44)
Sulfur chelates. XVI. Chemical properties of oxidized nickel(II) dithiocarbamates. X-ray crystal structure of tris(N,N-dibutyldithiocarbamato)nickel(IV)bromide, NiC27H54N3S6Br (1973) (43)
How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood-brain barrier permeability? (2011) (41)
Lamivudine permeability study: a comparison between PAMPA, ex vivo and in situ Single-Pass Intestinal Perfusion (SPIP) in rat jejunum. (2013) (40)
Bjerrum plots for the determination of systematic concentration errors in titration data (1982) (40)
A PAMPA Study of the Permeability‐Enhancing Effect of New Ceramide Analogues (2009) (40)
Acid-base cosolvent method for determining aqueous permeability of amiodarone, itraconazole, tamoxifen, terfenadine and other very insoluble molecules. (2004) (39)
Classification structure-activity relations (C-SAR) in prediction of human intestinal absorption. (2003) (39)
Crystal and molecular structure of tris(tropolonato)manganese(III), Mn(O2C7H5)3, a high-spin complex having structural features consistent with Jahn-Teller behavior for two distinct MnO6 centers (1974) (38)
Weighting scheme for regression analysis using pH data from acid—base titrations (1983) (36)
Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine. (2004) (36)
Structural characterization of tris(N,N-di-n-butyldithiocarbamato)nickel(IV) bromide. A Ni-S6 complex with unusual chemical properties (1970) (35)
Reversible oxygen carriers. The synthesis and low temperature (-171.degree.) structure of an unstable monomeric dioxygen adduct of N,N'-(1,1,2,2-tetramethyl)ethylenebis(3-fluorosalicylideniminato)(1-methylimidazole)cobalt(II), Co(3-F-Saltmen)(1-Me-Imid)(O2).2Me2CO (1976) (34)
Suggested Improvements for Measurement of Equilibrium Solubility-pH of Ionizable Drugs (2015) (34)
Perspectives in solubility measurement and interpretation (2019) (32)
The Critical Role of Passive Permeability in Designing Successful Drugs (2020) (31)
Solubility Challenge Revisited after Ten Years, with Multilab Shake-Flask Data, Using Tight (SD ∼ 0.17 log) and Loose (SD ∼ 0.62 log) Test Sets (2019) (30)
Predicting the exposure and antibacterial activity of fluoroquinolones based on physicochemical properties. (2012) (30)
Technical Note: Miniaturized Intrinsic Dissolution Rate (Mini-IDR™) Measurement of Griseofulvin and Carbamazepine (2007) (29)
High‐throughput Measurement of Permeability Profiles (2004) (29)
Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database (2020) (27)
Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size (2009) (26)
Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat—Biophysical Model and Predictions Based on Caco-2 (2017) (26)
pH-metric log P. 6. Effects of sodium, potassium, and N-CH3-D-glucamine on the octanol-water partitioning of prostaglandins E1 and E2. (1995) (25)
Salt Solubility Products of Diprenorphine Hydrochloride, Codeine and Lidocaine Hydrochlorides and Phosphates - Novel Method of Data Analysis Not Dependent on Explicit Solubility Equations (2013) (23)
A New In Situ Brain Perfusion Flow Correction Method for Lipophilic Drugs Based on the pH-Dependent Crone-Renkin Equation (2011) (22)
Anomalous Solubility Behavior of Several Acidic Drugs (2014) (22)
Solubility Temperature Dependence Predicted from 2D Structure (2015) (20)
Assessment of Distribution‐pH Profiles (2008) (19)
Free metal and free ligand concentrations determined from titrations using only a pH electrode. Partial derivatives in equilibrium studies (1979) (18)
Cocrystal solubility product analysis – Dual concentration‐pH mass action model not dependent on explicit solubility equations (2017) (18)
Findings of the Second Challenge to Predict Aqueous Solubility (2020) (18)
Phosphate Precipitates and Water-Soluble Aggregates in Re-analyzed Solubility-pH Data of Twenty-five Basic Drugs (2014) (18)
Solubility‐pH profile of desipramine hydrochloride in saline phosphate buffer: Enhanced solubility due to drug‐buffer aggregates (2019) (18)
In situ Fiber Optic Dissolution Monitoring of a Vitamin B12 Solid Dosage Formulation (2003) (17)
Structural trends of tris(acetylacetonate)-, tris(tropolonate)-, and other tris(bidentate ligand)-metal complexes. Additional comments on the trigonal twist and ligand-ligand repulsions in octahedral D3 bidentate ligand-metal complexes (1975) (17)
In Vitro Assays for Assessing BBB Permeability (2015) (17)
Cadmium binding by biological ligands. III: Five- and seven-cadmium binding in metallothionein: a detailed thermodynamic study (1985) (16)
Phenothiazines solution complexity - Determination of pKa and solubility-pH profiles exhibiting sub-micellar aggregation at 25 and 37°C. (2016) (16)
Equilibrium solubility measurement of compounds with low dissolution rate by Higuchi's Facilitated Dissolution Method. A validation study (2017) (15)
Cadmium binding by biological ligands. 1. Formation of protonated polynuclear complexes between cadmium and D-penicillamine in aqueous solution (1982) (15)
Cocrystal Solubility Product Prediction Using an in combo Model and Simulations to Improve Design of Experiments (2018) (14)
In vitro porcine blood-brain barrier model for permeability studies: pCEL-X software pKa(FLUX) method for aqueous boundary layer correction and detailed data analysis. (2014) (14)
Absorption Screening Using the PAMPA Approach (2004) (13)
Reversible oxygen carriers. Synthesis and structure of .mu.-dioxygen-bis[N,N'-ethylenebis(salicylideniminato)piperidinecobalt] acetonate piperidinate (C5H11NCoSalen)2(O2).cntdot.0.67(CH3)2CO.cntdot.0.33C5H11N7 (1976) (13)
'Flexible-acceptor' General Solubility Equation for 'beyond Rule of 5' Drugs. (2020) (13)
STRUCTURAL TRENDS OF TRIS(ACETYLACETONATE)‐, TRIS(TROPOLONATE)‐, AND OTHER TRIS(BIDENTATE LIGAND)‐METAL COMPLEXES. ADDITIONAL COMMENTS ON THE TRIGONAL TWIST AND LIGAND‐LIGAND REPULSIONS IN ′OCTAHEDRAL′D3 BIDENTATE LIGAND‐METAL COMPLEXES (1975) (12)
Cadmium binding by biological ligands. 5. Solution studies of cadmium and zinc binding by sulfhydryl ligands N,N'-dimethyl-N,N'-bis(2-mercaptoethyl)ethylenediamine and (2-mercaptoethyl)amine (1992) (12)
pKa-critical Interpretations of Solubility–pH Profiles: PG-300995 and NSC-639829 Case Studies (2015) (12)
Bis(triphenylphosphine)ethyltrithiocarbonatocopper(I) (1975) (11)
7. Permeability—PAMPA (2012) (11)
Computer generation of cubic molecular symmetry orbitals (1973) (11)
STBLTY: Methods for Construction and Refinement of Equilibrium Models (1985) (10)
Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods (2019) (10)
Drug Ionization and Physicochemical Profiling (2007) (9)
Can small drugs predict the intrinsic aqueous solubility of ‘beyond Rule of 5’ big drugs? (2020) (8)
Composition of ternary (metal-ligand-hydrogen) complexes experimentally determined from titrations using only a pH electrode (1980) (7)
Ionizable Drug Self-Associations and the Solubility Dependence on pH: Detection of Aggregates in Saturated Solutions Using Mass Spectrometry (ESI-Q-TOF-MS/MS). (2021) (7)
Cadmium binding by biological ligands. 2 [1]. Formation of protonated and polynuclear complexes between cadmium and 2-mercaptoethylamine (1984) (7)
Predicting Solubility of Newly-Approved Drugs (2016–2020) with a Simple ABSOLV and GSE(Flexible-Acceptor) Consensus Model Outperforming Random Forest Regression (2022) (7)
High‐Throughput Solubility, Permeability, and the MAD PAMPA Model (2007) (7)
Octanol–Water Partitioning (2012) (6)
Measurement of pKa and log P of water-insoluble substances by potentiometric titration (1993) (5)
Do you know your r2? (2020) (5)
Salt solubility and disproportionation – uses and limitations of equations for pHmax and the in-silico prediction of pHmax (2021) (5)
Partitioning into Octanol (2003) (5)
Permeability: Caco‐2/MDCK (2012) (5)
Limits for successful measurement of pKA and logP by pH-metric titration (1995) (4)
pH-Metric Solubility. 2: Correlation (4)
Cadmium binding by biological ligands. Part 4. Polynuclear complexes of cadmium with 2,3-dimercaptopropane-1-sulphonic acid (1991) (4)
Disproportionation of Pharmaceutical Salts: pHmax and Phase-Solubility/pH Variance. (2021) (3)
Is equilibrium slurry pH a good surrogate for solid surface pH during drug dissolution? (2021) (3)
Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule "Soft" Constraints. (2022) (3)
Cocrystal solubility-pH and drug solubilization capacity of sodium dodecyl sulfate – mass action model for data analysis and simulation to improve design of experiments (2018) (3)
Permeability: Blood–Brain Barrier (2012) (2)
Partitioning into Liposomes (2003) (2)
Predicting the human jejunal permeability and fraction absorbed of fluoroquinolones based on a biophysical model. (2014) (2)
Impact of capillary flow hydrodynamics on carrier‐mediated transport of opioid derivatives at the blood‐brain barrier, based on pH‐dependent Michaelis‐Menten and Crone‐Renkin analyses (2017) (2)
3. pKa Determination (2012) (1)
Understanding the pH Dependence of Supersaturation State—A Case Study of Telmisartan (2022) (1)
Filter-Immobilized Artificial Membrane (f-IAM) Permeability Assay: A New High-Throughput In Vitro Drug Absorption Model (2001) (1)
A versatile potentiometric analyzer. Part two. Multiple known addition and Gran titration techniques. (1987) (1)
Prediction of Caco-2 pH-Dependent Permeability based on High-Quality in vitro Training Set (2008) (1)
Factors Influencing the Water Solubilities of Crystalline Drugs (2004) (1)
Trends in PhysChem Properties of Newly Approved Drugs over the Last Six Years; Predicting Solubility of Drugs Approved in 2021 (2022) (1)
Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat—Biophysical Model and Predictions Based on Caco-2 (2017) (1)
2020 Reviewer Thanks (2021) (0)
Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development (2022) (0)
Summary and Some Simple Approximations (2012) (0)
CADMIUM BINDING BY BIOLOGICAL LIGANDS. 3. FIVE- AND SEVEN-CADMIUM BINDING IN METALLOTHIONEIN: A DETAILED THERMODYNAMIC STUDY (1985) (0)
Cocrystal Solubility Product Prediction Using an in combo Model and Simulations to Improve Design of Experiments (2018) (0)
CADMIUM BINDING BY BIOLOGICAL LIGANDS. 2. FORMATION OF PROTONATED AND POLYNUCLEAR COMPLEXES BETWEEN CADMIUM AND 2-MERCAPTOETHYLAMINE (1984) (0)
Estimating the Water Solubilities of Crystalline Compounds from Their Chemical Structures Alone. (2001) (0)
Potentiometric CheqSol and Standardized Shake-Flask Solubility Methods are Complimentary Tools in Physicochemical Profiling. (2020) (0)
A method and apparatus for measuring the membrane permeability (2003) (0)
Summary and Some Simple Rules (2003) (0)
Reversible Oxygen Carriers. The Synthesis and Low Temperature (-171°) Structure of an Unstable Monomeric Dioxygen Adduct of N,N′-(1,1,2,2-Tetramethyl)ethylene-bis(3-fluorosalicylidenaminato)(1-methylimidazole)cobalt(II),Co(3-F-Saltmen (1976) (0)
Thickness of the aqueous boundary layer in stirred microtitre plate permeability assays (PAMPA and Caco-2), based on the Levich equation (2022) (0)
二つの分れたMnO6中心に対するJahn‐Teller効果に一致した構造特性を有する高スピン錯体Mn(O2C7H5)3の結晶構造と分子構造 (1974) (0)
Konstantin Tsinman (1968-2020) (2022) (0)
Liposome–Water Partitioning (2012) (0)
Featured Article PAMPAYExcipient Classification Gradient Map (2006) (0)
Comparison of Miniaturized Intrinsic Dissolution Ra te Measurement to Traditional Wood's Apparatus (2007) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Alex Avdeef?

Alex Avdeef is affiliated with the following schools:

University of California, Berkeley
Uppsala University
Stanford University
University of California, San Francisco

Alex Avdeef's Academic­Influence.com Rankings

Alex Avdeef's Degrees

Why Is Alex Avdeef Influential?

Alex Avdeef's Published Works

Published Works

What Schools Are Affiliated With Alex Avdeef?

Alex Avdeef's AcademicInfluence.com Rankings