Alex Avdeef
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Alex Avdeefchemistry Degrees
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Alex Avdeefbiology Degrees
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Chemistry Biology
Alex Avdeef's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Chemistry Stanford University
- Bachelors Chemistry University of California, Berkeley
Why Is Alex Avdeef Influential?
(Suggest an Edit or Addition)Alex Avdeef's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Coexistence of passive and carrier-mediated processes in drug transport (2010) (525)
- Absorption and Drug Development: Solubility, Permeability, and Charge State (2003) (491)
- Physicochemical Profiling (Solubility, Permeability and Charge State) (2001) (340)
- pH-Metric logP 10. Determination of Liposomal Membrane-Water Partition Coefficients of lonizable Drugs (1998) (339)
- Absorption and drug development (2003) (252)
- Solubility of sparingly-soluble ionizable drugs. (2007) (250)
- Coordination chemistry of microbial iron transport compounds. 9. Stability constants for catechol models of enterobactin (1978) (250)
- Absorption classification of oral drugs based on molecular surface properties. (2003) (233)
- COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT COMPOUNDS. 19. STABILITY CONSTANTS AND ELECTROCHEMICAL BEHAVIOR OF FERRIC ENTEROBACTIN AND MODEL COMPLEXES (1979) (224)
- pH-Metric Solubility. 2: Correlation Between the Acid-Base Titration and the Saturation Shake-Flask Solubility-pH Methods (2004) (218)
- Classification Analysis of P-Glycoprotein Substrate Specificity (2003) (217)
- pH-Metric log P. 3. Glass electrode calibration in methanol-water, applied to pKa determination of water-insoluble substances (1993) (213)
- PH-metric log P 11. pKa determination of water-insoluble drugs in organic solvent-water mixtures. (1999) (204)
- PAMPA--critical factors for better predictions of absorption. (2007) (199)
- Physicochemical profiling (solubility, permeability and charge state). (2001) (196)
- pH-metric log P. II: Refinement of partition coefficients and ionization constants of multiprotic substances. (1993) (192)
- PAMPA--a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones. (2004) (181)
- In vitro trans-monolayer permeability calculations: often forgotten assumptions. (2003) (175)
- Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA method (2005) (172)
- The rise of PAMPA (2005) (166)
- Dissolution rate and apparent solubility of poorly soluble drugs in biorelevant dissolution media. (2010) (150)
- pH‐Metric log P. Part 1. Difference Plots for Determining Ion‐Pair Octanol‐Water Partition Coefficients of Multiprotic Substances (1992) (148)
- PAMPA--a drug absorption in vitro model 13. Chemical selectivity due to membrane hydrogen bonding: in combo comparisons of HDM-, DOPC-, and DS-PAMPA models. (2004) (148)
- Skin-PAMPA: a new method for fast prediction of skin penetration. (2012) (143)
- Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques (2002) (142)
- PAMPA--a drug absorption in vitro model 11. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates. (2004) (142)
- Potentiometric pKa determination of water-insoluble compounds: validation study in methanol/water mixtures (1997) (140)
- Drug absorption in vitro model: filter-immobilized artificial membranes. 2. Studies of the permeability properties of lactones in Piper methysticum Forst. (2001) (137)
- Interlaboratory study of log P determination by shake-flask and potentiometric methods. (1996) (131)
- Accurate measurements of the concentration of hydrogen ions with a glass electrode: calibrations using the Prideaux and other universal buffer solutions and a computer-controlled automatic titrator (1978) (110)
- Two isostructural actinide .pi. complexes. Crystal and molecular structure of bis(cyclooctatetraenyl)uranium(IV), U(C8H8)2, and bis(cyclooctatetraenyl)thorium(IV), Th(C8H8)2 (1972) (109)
- Advances in screening for membrane permeability: high-resolution PAMPA for medicinal chemists. (2004) (106)
- Evidence-based approach to assess passive diffusion and carrier-mediated drug transport. (2012) (105)
- Miniaturized Rotating Disk Intrinsic Dissolution Rate Measurement: Effects of Buffer Capacity in Comparisons to Traditional Wood’s Apparatus (2008) (103)
- pH-metric solubility. 3. Dissolution titration template method for solubility determination. (2001) (99)
- Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition. (2014) (98)
- PAMPA--a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa(flux)--optimized design (pOD-PAMPA). (2003) (92)
- pH-metric log P. 4. Comparison of partition coefficients determined by HPLC and potentiometric methods to literature values. (1994) (92)
- How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? (2010) (88)
- Calibration of copper ion selective electrode response to pCu 19 (1983) (88)
- Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method. (2005) (84)
- Octanol-, chloroform-, and propylene glycol dipelargonat-water partitioning of morphine-6-glucuronide and other related opiates. (1996) (82)
- Structure-Lipophilicity Relationships of Neutral and Protonated β-Blockers, Part I, Intra- and Intermolecular Effects in Isotropic Solvent Systems (1999) (81)
- Crystal and molecular structure of tris(2,4-pentanedionato)manganese(III), Mn(O2C5H7)3, a distorted complex as predicted by Jahn-Teller arguments (1974) (79)
- Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion—Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model (2011) (78)
- Determination of protonation macro- and microconstants and octanol/water partition coefficient of the antiinflammatory drug niflumic acid. (1994) (75)
- PAMPA--a drug absorption in vitro model 8. Apparent filter porosity and the unstirred water layer. (2004) (75)
- Equilibrium solubility measurement of ionizable drugs - consensus recommendations for improving data quality (2016) (75)
- In Vitro Permeability of Poorly Aqueous Soluble Compounds Using Different Solubilizers in the PAMPA Assay with Liquid Chromatography/Mass Spectrometry Detection (2003) (74)
- P-glycoprotein deficient mouse in situ blood-brain barrier permeability and its prediction using an in combo PAMPA model. (2009) (74)
- Leakiness and Size Exclusion of Paracellular Channels in Cultured Epithelial Cell Monolayers–Interlaboratory Comparison (2010) (72)
- Estimating the Water Solubilities of Crystalline Compounds from Their Chemical Structures Alone (2001) (67)
- Powder Dissolution Method for Estimating Rotating Disk Intrinsic Dissolution Rates of Low Solubility Drugs (2009) (65)
- Permeation of permanently positive charged molecules through artificial membranes--influence of physico-chemical properties. (2007) (65)
- pH‐metric Solubility. 1. Solubility‐pH Profiles from Bjerrum Plots. Gibbs Buffer and pKa in the Solid State (1998) (63)
- Dissolution and Solubility (2007) (57)
- Solubility-Excipient Classification Gradient Maps (2007) (57)
- High‐Throughput Measurements of Solubility Profiles (2007) (55)
- PAMPA–Excipient Classification Gradient Map (2006) (54)
- Studies of the cubane cluster of copper(I). A modified self-consistent charge and configuration molecular orbital investigation of the cluster containing the Cu8S124- core (1978) (52)
- Membrane–Water partitioning, membrane permeability, and baseline toxicity of the parasiticides ivermectin, albendazole, and morantel (2008) (49)
- The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability. (2010) (48)
- Biorelevant pK(a) (37 °C) predicted from the 2D structure of the molecule and its pK(a) at 25 °C. (2011) (46)
- Absorption-excipient-pH classification gradient maps: sparingly soluble drugs and the pH partition hypothesis. (2008) (44)
- Sulfur chelates. XVI. Chemical properties of oxidized nickel(II) dithiocarbamates. X-ray crystal structure of tris(N,N-dibutyldithiocarbamato)nickel(IV)bromide, NiC27H54N3S6Br (1973) (43)
- How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood-brain barrier permeability? (2011) (41)
- Lamivudine permeability study: a comparison between PAMPA, ex vivo and in situ Single-Pass Intestinal Perfusion (SPIP) in rat jejunum. (2013) (40)
- Bjerrum plots for the determination of systematic concentration errors in titration data (1982) (40)
- A PAMPA Study of the Permeability‐Enhancing Effect of New Ceramide Analogues (2009) (40)
- Acid-base cosolvent method for determining aqueous permeability of amiodarone, itraconazole, tamoxifen, terfenadine and other very insoluble molecules. (2004) (39)
- Classification structure-activity relations (C-SAR) in prediction of human intestinal absorption. (2003) (39)
- Crystal and molecular structure of tris(tropolonato)manganese(III), Mn(O2C7H5)3, a high-spin complex having structural features consistent with Jahn-Teller behavior for two distinct MnO6 centers (1974) (38)
- Weighting scheme for regression analysis using pH data from acid—base titrations (1983) (36)
- Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine. (2004) (36)
- Structural characterization of tris(N,N-di-n-butyldithiocarbamato)nickel(IV) bromide. A Ni-S6 complex with unusual chemical properties (1970) (35)
- Reversible oxygen carriers. The synthesis and low temperature (-171.degree.) structure of an unstable monomeric dioxygen adduct of N,N'-(1,1,2,2-tetramethyl)ethylenebis(3-fluorosalicylideniminato)(1-methylimidazole)cobalt(II), Co(3-F-Saltmen)(1-Me-Imid)(O2).2Me2CO (1976) (34)
- Suggested Improvements for Measurement of Equilibrium Solubility-pH of Ionizable Drugs (2015) (34)
- Perspectives in solubility measurement and interpretation (2019) (32)
- The Critical Role of Passive Permeability in Designing Successful Drugs (2020) (31)
- Solubility Challenge Revisited after Ten Years, with Multilab Shake-Flask Data, Using Tight (SD ∼ 0.17 log) and Loose (SD ∼ 0.62 log) Test Sets (2019) (30)
- Predicting the exposure and antibacterial activity of fluoroquinolones based on physicochemical properties. (2012) (30)
- Technical Note: Miniaturized Intrinsic Dissolution Rate (Mini-IDR™) Measurement of Griseofulvin and Carbamazepine (2007) (29)
- High‐throughput Measurement of Permeability Profiles (2004) (29)
- Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database (2020) (27)
- Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size (2009) (26)
- Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat—Biophysical Model and Predictions Based on Caco-2 (2017) (26)
- pH-metric log P. 6. Effects of sodium, potassium, and N-CH3-D-glucamine on the octanol-water partitioning of prostaglandins E1 and E2. (1995) (25)
- Salt Solubility Products of Diprenorphine Hydrochloride, Codeine and Lidocaine Hydrochlorides and Phosphates - Novel Method of Data Analysis Not Dependent on Explicit Solubility Equations (2013) (23)
- A New In Situ Brain Perfusion Flow Correction Method for Lipophilic Drugs Based on the pH-Dependent Crone-Renkin Equation (2011) (22)
- Anomalous Solubility Behavior of Several Acidic Drugs (2014) (22)
- Solubility Temperature Dependence Predicted from 2D Structure (2015) (20)
- Assessment of Distribution‐pH Profiles (2008) (19)
- Free metal and free ligand concentrations determined from titrations using only a pH electrode. Partial derivatives in equilibrium studies (1979) (18)
- Cocrystal solubility product analysis – Dual concentration‐pH mass action model not dependent on explicit solubility equations (2017) (18)
- Findings of the Second Challenge to Predict Aqueous Solubility (2020) (18)
- Phosphate Precipitates and Water-Soluble Aggregates in Re-analyzed Solubility-pH Data of Twenty-five Basic Drugs (2014) (18)
- Solubility‐pH profile of desipramine hydrochloride in saline phosphate buffer: Enhanced solubility due to drug‐buffer aggregates (2019) (18)
- In situ Fiber Optic Dissolution Monitoring of a Vitamin B12 Solid Dosage Formulation (2003) (17)
- Structural trends of tris(acetylacetonate)-, tris(tropolonate)-, and other tris(bidentate ligand)-metal complexes. Additional comments on the trigonal twist and ligand-ligand repulsions in octahedral D3 bidentate ligand-metal complexes (1975) (17)
- In Vitro Assays for Assessing BBB Permeability (2015) (17)
- Cadmium binding by biological ligands. III: Five- and seven-cadmium binding in metallothionein: a detailed thermodynamic study (1985) (16)
- Phenothiazines solution complexity - Determination of pKa and solubility-pH profiles exhibiting sub-micellar aggregation at 25 and 37°C. (2016) (16)
- Equilibrium solubility measurement of compounds with low dissolution rate by Higuchi's Facilitated Dissolution Method. A validation study (2017) (15)
- Cadmium binding by biological ligands. 1. Formation of protonated polynuclear complexes between cadmium and D-penicillamine in aqueous solution (1982) (15)
- Cocrystal Solubility Product Prediction Using an in combo Model and Simulations to Improve Design of Experiments (2018) (14)
- In vitro porcine blood-brain barrier model for permeability studies: pCEL-X software pKa(FLUX) method for aqueous boundary layer correction and detailed data analysis. (2014) (14)
- Absorption Screening Using the PAMPA Approach (2004) (13)
- Reversible oxygen carriers. Synthesis and structure of .mu.-dioxygen-bis[N,N'-ethylenebis(salicylideniminato)piperidinecobalt] acetonate piperidinate (C5H11NCoSalen)2(O2).cntdot.0.67(CH3)2CO.cntdot.0.33C5H11N7 (1976) (13)
- 'Flexible-acceptor' General Solubility Equation for 'beyond Rule of 5' Drugs. (2020) (13)
- STRUCTURAL TRENDS OF TRIS(ACETYLACETONATE)‐, TRIS(TROPOLONATE)‐, AND OTHER TRIS(BIDENTATE LIGAND)‐METAL COMPLEXES. ADDITIONAL COMMENTS ON THE TRIGONAL TWIST AND LIGAND‐LIGAND REPULSIONS IN ′OCTAHEDRAL′D3 BIDENTATE LIGAND‐METAL COMPLEXES (1975) (12)
- Cadmium binding by biological ligands. 5. Solution studies of cadmium and zinc binding by sulfhydryl ligands N,N'-dimethyl-N,N'-bis(2-mercaptoethyl)ethylenediamine and (2-mercaptoethyl)amine (1992) (12)
- pKa-critical Interpretations of Solubility–pH Profiles: PG-300995 and NSC-639829 Case Studies (2015) (12)
- Bis(triphenylphosphine)ethyltrithiocarbonatocopper(I) (1975) (11)
- 7. Permeability—PAMPA (2012) (11)
- Computer generation of cubic molecular symmetry orbitals (1973) (11)
- STBLTY: Methods for Construction and Refinement of Equilibrium Models (1985) (10)
- Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods (2019) (10)
- Drug Ionization and Physicochemical Profiling (2007) (9)
- Can small drugs predict the intrinsic aqueous solubility of ‘beyond Rule of 5’ big drugs? (2020) (8)
- Composition of ternary (metal-ligand-hydrogen) complexes experimentally determined from titrations using only a pH electrode (1980) (7)
- Ionizable Drug Self-Associations and the Solubility Dependence on pH: Detection of Aggregates in Saturated Solutions Using Mass Spectrometry (ESI-Q-TOF-MS/MS). (2021) (7)
- Cadmium binding by biological ligands. 2 [1]. Formation of protonated and polynuclear complexes between cadmium and 2-mercaptoethylamine (1984) (7)
- Predicting Solubility of Newly-Approved Drugs (2016–2020) with a Simple ABSOLV and GSE(Flexible-Acceptor) Consensus Model Outperforming Random Forest Regression (2022) (7)
- High‐Throughput Solubility, Permeability, and the MAD PAMPA Model (2007) (7)
- Octanol–Water Partitioning (2012) (6)
- Measurement of pKa and log P of water-insoluble substances by potentiometric titration (1993) (5)
- Do you know your r2? (2020) (5)
- Salt solubility and disproportionation – uses and limitations of equations for pHmax and the in-silico prediction of pHmax (2021) (5)
- Partitioning into Octanol (2003) (5)
- Permeability: Caco‐2/MDCK (2012) (5)
- Limits for successful measurement of pKA and logP by pH-metric titration (1995) (4)
- pH-Metric Solubility. 2: Correlation (4)
- Cadmium binding by biological ligands. Part 4. Polynuclear complexes of cadmium with 2,3-dimercaptopropane-1-sulphonic acid (1991) (4)
- Disproportionation of Pharmaceutical Salts: pHmax and Phase-Solubility/pH Variance. (2021) (3)
- Is equilibrium slurry pH a good surrogate for solid surface pH during drug dissolution? (2021) (3)
- Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule "Soft" Constraints. (2022) (3)
- Cocrystal solubility-pH and drug solubilization capacity of sodium dodecyl sulfate – mass action model for data analysis and simulation to improve design of experiments (2018) (3)
- Permeability: Blood–Brain Barrier (2012) (2)
- Partitioning into Liposomes (2003) (2)
- Predicting the human jejunal permeability and fraction absorbed of fluoroquinolones based on a biophysical model. (2014) (2)
- Impact of capillary flow hydrodynamics on carrier‐mediated transport of opioid derivatives at the blood‐brain barrier, based on pH‐dependent Michaelis‐Menten and Crone‐Renkin analyses (2017) (2)
- 3. pKa Determination (2012) (1)
- Understanding the pH Dependence of Supersaturation State—A Case Study of Telmisartan (2022) (1)
- Filter-Immobilized Artificial Membrane (f-IAM) Permeability Assay: A New High-Throughput In Vitro Drug Absorption Model (2001) (1)
- A versatile potentiometric analyzer. Part two. Multiple known addition and Gran titration techniques. (1987) (1)
- Prediction of Caco-2 pH-Dependent Permeability based on High-Quality in vitro Training Set (2008) (1)
- Factors Influencing the Water Solubilities of Crystalline Drugs (2004) (1)
- Trends in PhysChem Properties of Newly Approved Drugs over the Last Six Years; Predicting Solubility of Drugs Approved in 2021 (2022) (1)
- Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat—Biophysical Model and Predictions Based on Caco-2 (2017) (1)
- 2020 Reviewer Thanks (2021) (0)
- Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development (2022) (0)
- Summary and Some Simple Approximations (2012) (0)
- CADMIUM BINDING BY BIOLOGICAL LIGANDS. 3. FIVE- AND SEVEN-CADMIUM BINDING IN METALLOTHIONEIN: A DETAILED THERMODYNAMIC STUDY (1985) (0)
- Cocrystal Solubility Product Prediction Using an in combo Model and Simulations to Improve Design of Experiments (2018) (0)
- CADMIUM BINDING BY BIOLOGICAL LIGANDS. 2. FORMATION OF PROTONATED AND POLYNUCLEAR COMPLEXES BETWEEN CADMIUM AND 2-MERCAPTOETHYLAMINE (1984) (0)
- Estimating the Water Solubilities of Crystalline Compounds from Their Chemical Structures Alone. (2001) (0)
- Potentiometric CheqSol and Standardized Shake-Flask Solubility Methods are Complimentary Tools in Physicochemical Profiling. (2020) (0)
- A method and apparatus for measuring the membrane permeability (2003) (0)
- Summary and Some Simple Rules (2003) (0)
- Reversible Oxygen Carriers. The Synthesis and Low Temperature (-171°) Structure of an Unstable Monomeric Dioxygen Adduct of N,N′-(1,1,2,2-Tetramethyl)ethylene-bis(3-fluorosalicylidenaminato)(1-methylimidazole)cobalt(II),Co(3-F-Saltmen (1976) (0)
- Thickness of the aqueous boundary layer in stirred microtitre plate permeability assays (PAMPA and Caco-2), based on the Levich equation (2022) (0)
- 二つの分れたMnO6中心に対するJahn‐Teller効果に一致した構造特性を有する高スピン錯体Mn(O2C7H5)3の結晶構造と分子構造 (1974) (0)
- Konstantin Tsinman (1968-2020) (2022) (0)
- Liposome–Water Partitioning (2012) (0)
- Featured Article PAMPAYExcipient Classification Gradient Map (2006) (0)
- Comparison of Miniaturized Intrinsic Dissolution Ra te Measurement to Traditional Wood's Apparatus (2007) (0)
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