Alex Bateman
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British bioinformatician
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Why Is Alex Bateman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Alexander George Bateman is a computational biologist and Head of Protein Sequence Resources at the European Bioinformatics Institute , part of the European Molecular Biology Laboratory in Cambridge, UK. He has led the development of the Pfam biological database and introduced the Rfam database of RNA families. He has also been involved in the use of Wikipedia for community-based annotation of biological databases.
Alex Bateman's Published Works
Published Works
- Initial sequencing and analysis of the human genome. (2001) (15222)
- Pfam: the protein families database (2013) (12454)
- The Pfam protein families database (2005) (7519)
- The Pfam protein families database: towards a more sustainable future (2015) (4710)
- miRBase: microRNA sequences, targets and gene nomenclature (2005) (4563)
- The Pfam protein families database in 2019 (2018) (3247)
- UniProt: the universal protein knowledgebase in 2021 (2020) (3156)
- Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) (2002) (2919)
- The Pfam protein families database (2004) (2565)
- UniProt: A hub for protein information (2015) (2447)
- Pfam: clans, web tools and services (2005) (2262)
- An introduction to hidden Markov models. (2007) (2208)
- InterPro: the integrative protein signature database (2008) (1850)
- Activities at the Universal Protein Resource (UniProt) (2013) (1821)
- UniProt: the universal protein knowledgebase (2016) (1805)
- Pfam: The protein families database in 2021 (2020) (1725)
- The Gene Ontology resource: enriching a GOld mine (2020) (1508)
- The Gene Ontology Resource: 20 years and still GOing strong (2019) (1467)
- Rfam: an RNA family database (2003) (1446)
- Rfam: annotating non-coding RNAs in complete genomes (2004) (1419)
- InterPro in 2017—beyond protein family and domain annotations (2016) (1217)
- The InterPro protein families database: the classification resource after 15 years (2014) (1186)
- InterPro in 2011: new developments in the family and domain prediction database (2011) (1100)
- The InterPro database, an integrated documentation resource for protein families, domains and functional sites (2001) (1061)
- Highly accurate protein structure prediction for the human proteome (2021) (1032)
- MEROPS: the database of proteolytic enzymes, their substrates and inhibitors (2013) (981)
- Challenges in homology search: HMMER3 and convergent evolution of coiled-coil regions (2013) (925)
- The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database (2017) (906)
- Rfam 12.0: updates to the RNA families database (2014) (895)
- Rfam: updates to the RNA families database (2008) (861)
- The InterPro protein families and domains database: 20 years on (2020) (858)
- Pfam: multiple sequence alignments and HMM-profiles of protein domains (1998) (784)
- Rfam 11.0: 10 years of RNA families (2012) (772)
- Current Protocols in Bioinformatics (2002) (760)
- The InterPro Database, 2003 brings increased coverage and new features (2003) (742)
- MEROPS: the database of proteolytic enzymes, their substrates and inhibitors (2011) (733)
- HMMER web server: 2015 update (2015) (721)
- Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families (2017) (719)
- The immune-hypothalamic-pituitary-adrenal axis. (1989) (651)
- InterPro, progress and status in 2005 (2004) (573)
- New developments in the InterPro database (2007) (542)
- Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins (1999) (532)
- The structure of a domain common to archaebacteria and the homocystinuria disease protein. (1997) (521)
- Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis (2003) (461)
- Progranulin is a mediator of the wound response (2003) (448)
- Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain. (2000) (439)
- The structure of a LysM domain from E. coli membrane-bound lytic murein transglycosylase D (MltD). (2000) (425)
- Rfam: Wikipedia, clans and the “decimal” release (2010) (413)
- InterPro: An Integrated Documentation Resource for Protein Families, Domains and Functional Sites (2002) (376)
- Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. (2008) (368)
- Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake. (1999) (352)
- Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks (2012) (345)
- iPfam: visualization of protein?Cprotein interactions in PDB at domain and amino acid resolutions (2005) (323)
- Cellular Localization of Gene Expression for Progranulin (2000) (317)
- The granulin gene family: from cancer to dementia (2009) (310)
- QuickTree: building huge Neighbour-Joining trees of protein sequences (2002) (298)
- The Pfam protein families database (2009) (296)
- The tify family previously known as ZIM. (2007) (276)
- The Systematic Functional Analysis of Plasmodium Protein Kinases Identifies Essential Regulators of Mosquito Transmission (2010) (272)
- Rfam 14: expanded coverage of metagenomic, viral and microRNA families (2020) (265)
- Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling (2013) (252)
- Granulins: the structure and function of an emerging family of growth factors. (1998) (237)
- The CHAP domain: a large family of amidases including GSP amidase and peptidoglycan hydrolases. (2003) (233)
- Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. (1992) (230)
- The structure of a PKD domain from polycystin‐1: implications for polycystic kidney disease (1999) (225)
- The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest (2019) (224)
- Non‐Coding RNA Analysis Using the Rfam Database (2018) (221)
- The PASTA domain: a β-lactam-binding domain (2002) (215)
- Large-scale screening for novel low-affinity extracellular protein interactions. (2008) (213)
- The Pfam protein families database. (2004) (204)
- Granulins, a novel class of peptide from leukocytes. (1990) (201)
- DUFs: families in search of function (2010) (193)
- Neutrophil defensins induce histamine secretion from mast cells: mechanisms of action. (1999) (192)
- Biological activities and signaling pathways of the granulin/epithelin precursor. (1999) (184)
- Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo. (1999) (174)
- Predicting active site residue annotations in the Pfam database (2007) (170)
- The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases (2004) (170)
- The Pfam Protein Families Database (2002) (166)
- RNAcentral: a hub of information for non-coding RNA sequences (2018) (164)
- Fusogenic membrane glycoproteins as a novel class of genes for the local and immune-mediated control of tumor growth. (2000) (161)
- Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains. (1997) (161)
- Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival. (2002) (160)
- InterPro--an integrated documentation resource for protein families, domains and functional sites. (2000) (157)
- Alternative splicing of intrinsically disordered regions and rewiring of protein interactions. (2013) (156)
- Progranulin is expressed within motor neurons and promotes neuronal cell survival (2009) (152)
- Progranulin (acrogranin/PC cell‐derived growth factor/granulin‐epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development (2003) (150)
- Structure dissection of human progranulin identifies well‐folded granulin/epithelin modules with unique functional activities (2008) (146)
- The ENTH domain (2002) (144)
- iPfam: a database of protein family and domain interactions found in the Protein Data Bank (2013) (144)
- Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases (2019) (143)
- Outline structure of the human L1 cell adhesion molecule and the sites where mutations cause neurological disorders. (1996) (138)
- The COMBREX Project: Design, Methodology, and Initial Results (2013) (137)
- Membrane-bound progesterone receptors contain a cytochrome b5-like ligand-binding domain (2002) (137)
- The PLAT domain: a new piece in the PKD1 puzzle (1999) (132)
- Progranulin (granulin-epithelin precursor, PC-cell derived growth factor, acrogranin) in proliferation and tumorigenesis. (2003) (130)
- Protein interactions in human genetic diseases (2008) (130)
- Pfam 10 years on: 10 000 families and still growing (2008) (128)
- The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning. (1999) (128)
- TreeFam v9: a new website, more species and orthology-on-the-fly (2013) (126)
- Using deep learning to annotate the protein universe (2019) (124)
- UniProt: the Universal Protein Knowledgebase in 2023 (2022) (124)
- Structure, Function, and Mechanism of Progranulin; the Brain and Beyond (2011) (122)
- New Knowledge from Old: In silico discovery of novel protein domains in Streptomyces coelicolor (2003) (122)
- Viral fusogenic membrane glycoproteins kill solid tumor cells by nonapoptotic mechanisms that promote cross presentation of tumor antigens by dendritic cells. (2002) (118)
- Metazoan Scc4 Homologs Link Sister Chromatid Cohesion to Cell and Axon Migration Guidance (2006) (115)
- Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β (2010) (115)
- Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naïve T-cell priming (2005) (114)
- The evolution of protein domain families. (2009) (112)
- Quantifying the mechanisms of domain gain in animal proteins (2010) (111)
- RNAcentral: an international database of ncRNA sequences (2014) (108)
- A comparison of dense transposon insertion libraries in the Salmonella serovars Typhi and Typhimurium (2013) (107)
- Hanging in the balance. KIR and their role in disease. (2005) (106)
- Erratum: Initial sequencing and analysis of the human genome: International Human Genome Sequencing Consortium (Nature (2001) 409 (860-921)) (2001) (106)
- Use of viral fusogenic membrane glycoproteins as novel therapeutic transgenes in gliomas. (2001) (105)
- Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease (2017) (102)
- Dosage Sensitivity Shapes the Evolution of Copy-Number Varied Regions (2010) (98)
- Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research (2020) (96)
- Viral fusogenic membrane glycoprotein expression causes syncytia formation with bioenergetic cell death: implications for gene therapy. (2000) (96)
- The G5 domain: a potential N-acetylglucosamine recognition domain involved in biofilm formation (2005) (95)
- RNAcentral: a comprehensive database of non-coding RNA sequences (2016) (95)
- On expert curation and scalability: UniProtKB/Swiss-Prot as a case study (2017) (94)
- RNAcentral 2021: secondary structure integration, improved sequence search and new member databases (2020) (91)
- The PA domain: A protease‐associated domain (2000) (91)
- The HMMER Web Server for Protein Sequence Similarity Search (2017) (91)
- Structure and distribution of pentapeptide repeats in bacteria (1998) (90)
- The PASTA domain: a beta-lactam-binding domain. (2002) (88)
- Enhancing the efficacy of a weak allogeneic melanoma vaccine by viral fusogenic membrane glycoprotein-mediated tumor cell-tumor cell fusion. (2002) (88)
- The SIS domain: a phosphosugar-binding domain. (1999) (85)
- Structure of a novel human granulocyte peptide with anti-ACTH activity. (1988) (83)
- The BON domain: a putative membrane-binding domain. (2003) (77)
- RNAcentral: A vision for an international database of RNA sequences. (2011) (76)
- Postsynaptic block of a glutamatergic synapse by low molecular weight fractions of spider venom (1985) (76)
- The RNA WikiProject: community annotation of RNA families. (2008) (76)
- Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors (2008) (75)
- Structure and chromosomal location of the human granulin gene. (1992) (75)
- A new genetic method to generate and isolate small, short-lived but highly potent dendritic cell-tumor cell hybrid vaccines (2003) (74)
- InterPro in 2022 (2022) (73)
- The complementary deoxyribonucleic acid sequence, tissue distribution, and cellular localization of the rat granulin precursor. (1993) (73)
- The Pfam protein families database (2007) (72)
- Structure of azotobactin D, a siderophore of Azotobacter vinelandii strain D (CCM 289) (1988) (72)
- Identifying Protein Domains with the Pfam Database (2008) (72)
- Bacterial siderophores: structures of pyoverdins Pt, siderophores of Pseudomonas tolaasii NCPPB 2192, and pyoverdins Pf, siderophores of Pseudomonas fluorescens CCM 2798. Identification of an unusual natural amino acid. (1990) (72)
- Towards BioDBcore: a community-defined information specification for biological databases (2011) (71)
- TheDUTT1Gene, a Novel NCAM Family Member Is Expressed in Developing Murine Neural Tissues and Has an Unusually Broad Pattern of Expression (1998) (70)
- A lentiviral vector expressing a fusogenic glycoprotein for cancer gene therapy (2000) (70)
- The PepSY domain: a regulator of peptidase activity in the microbial environment? (2004) (70)
- Mining the draft human genome (2001) (70)
- RNIE: genome-wide prediction of bacterial intrinsic terminators (2011) (69)
- The Isolation and Characterization of a Novel Corticostatin/Defensin-like Peptide from the Kidney (*) (1996) (68)
- Members of the immunoglobulin superfamily in bacteria (1996) (67)
- Enhanced protein domain discovery by using language modeling techniques from speech recognition (2003) (65)
- HOMSTRAD: adding sequence information to structure-based alignments of homologous protein families (2001) (64)
- Distant homology recognition using structural classification of proteins (1997) (62)
- Biocurators and Biocuration: surveying the 21st century challenges (2012) (61)
- Altered Expression of Two-Pore Domain Potassium (K2P) Channels in Cancer (2013) (60)
- Adoptive transfer of immature dendritic cells with autologous or allogeneic tumor cells generates systemic antitumor immunity. (1999) (59)
- Progranulin is a stress-response factor in fibroblasts subjected to hypoxia and acidosis (2007) (57)
- Towards BioDBcore: a community-defined information specification for biological databases (2010) (57)
- Corticostatic peptides cause nifedipine-sensitive volume reduction in jejunal villus enterocytes. (1991) (55)
- Asparagine Peptide Lyases (2011) (54)
- Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1 (2010) (52)
- The Evolution of the Secreted Regulatory Protein Progranulin (2015) (52)
- Fusogenic membrane glycoprotein-mediated tumour cell fusion activates human dendritic cells for enhanced IL-12 production and T-cell priming (2006) (51)
- Databases, data tombs and dust in the wind (2008) (50)
- Bacterial Siderophores: Structure of Pyoverdins and Related Compounds (1986) (49)
- Dendritic Cells Trigger Tumor Cell Death by a Nitric Oxide-Dependent Mechanism1 (2007) (49)
- Reuse of structural domain–domain interactions in protein networks (2007) (49)
- The corticostatic (anti-ACTH) and cytotoxic activity of peptides isolated from fetal, adult and tumor-bearing lung. (1987) (49)
- Apoptotic, necrotic, or fused tumor cells: An equivalent source of antigen for dendritic cell loading (2006) (48)
- Identifying Protein Domains with the Pfam Database (2003) (48)
- Filling out the structural map of the NTF2-like superfamily (2013) (47)
- Expression of the Growth Factor Progranulin in Endothelial Cells Influences Growth and Development of Blood Vessels: A Novel Mouse Model (2013) (47)
- Mutations in GPAA1, Encoding a GPI Transamidase Complex Protein, Cause Developmental Delay, Epilepsy, Cerebellar Atrophy, and Osteopenia. (2017) (46)
- SnoPatrol: how many snoRNA genes are there? (2010) (45)
- Making your database available through Wikipedia: the pros and cons (2011) (45)
- Ten Simple Rules for Editing Wikipedia (2010) (45)
- SCOOP: a simple method for identification of novel protein superfamily relationships (2007) (45)
- Gene therapy for prostate cancer: current status and future prospects. (2001) (44)
- Regulation of progranulin expression in myeloid cells. (2006) (44)
- Isolation and biological activity of corticostatic peptides (anti-ACTH). (1989) (43)
- Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity (2017) (43)
- Visualizing profile-profile alignment: pairwise HMM logos (2005) (43)
- The inhibition of TNF-alpha anti-tumoral properties by blocking antibodies promotes tumor growth in a rat model. (2007) (43)
- Structure of the Escherichia coli ProQ RNA-binding protein. (2017) (42)
- Bioinformatics for next generation sequencing. (2009) (42)
- Cloud computing (2009) (41)
- Using the MEROPS Database for Proteolytic Enzymes and Their Inhibitors and Substrates (2014) (40)
- Structural and functional analysis of a promoter of the human granulin/epithelin gene. (1996) (40)
- Post-translational modification of bovine pro-opiomelanocortin. Tyrosine sulfation and pyroglutamate formation, a mass spectrometric study. (1990) (40)
- The rise and fall of supervised machine learning techniques (2011) (40)
- The levels and biologic action of the human neutrophil granule peptide HP-1 in lung tumors (1992) (39)
- Intratumoral expression of a fusogenic membrane glycoprotein enhances the efficacy of replicating adenovirus therapy (2003) (38)
- Radiation-induced cell death and dendritic cells: potential for cancer immunotherapy? (2005) (38)
- Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models. (2013) (38)
- Curators of the world unite: the International Society of Biocuration (2010) (37)
- Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states (2020) (37)
- HMM-based databases in InterPro (2002) (36)
- A transcriptional feedback loop for tissue-specific expression of highly cytotoxic genes which incorporates an immunostimulatory component (2001) (36)
- A Brief Overview of Progranulin in Health and Disease. (2018) (36)
- Pepsin homologues in bacteria (2009) (35)
- The SGS3 protein involved in PTGS finds a family (2002) (34)
- Development and application of mass spectrometric methods for the analysis of progranulin N-glycosylation. (2010) (34)
- The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins (2003) (34)
- Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain (2010) (34)
- UniProt-DAAC: domain architecture alignment and classification, a new method for automatic functional annotation in UniProtKB (2016) (33)
- Bioimage informatics: a new category in Bioinformatics (2012) (31)
- AntiFam: a tool to help identify spurious ORFs in protein annotation (2012) (31)
- Spatiotemporal expression pattern of progranulin in embryo implantation and placenta formation suggests a role in cell proliferation, remodeling, and angiogenesis. (2008) (31)
- The use of structure information to increase alignment accuracy does not aid homologue detection with profile HMMs (2002) (30)
- The challenge of increasing Pfam coverage of the human proteome (2013) (30)
- A Member of the Immunoglobulin Superfamily in Bacteriophage T4 (2004) (30)
- Corrigendum: ''RNAcentral : a hub of information for non-coding RNA sequences'' [Nucleic acids research, 47 (2019) D1, p. D221-D229] (2019) (30)
- Novel protein domains and motifs in the marine planctomycete Rhodopirellula baltica. (2004) (30)
- Bacterial siderophores: unusual 3,4,5,6-tetrahydropyrimidine-based amino acids in pyoverdins frompseudomonas fluorescens (1990) (30)
- Fibronectin type III domains in yeast detected by a hidden Markov model (1996) (29)
- The isolation and identification of multiple forms of the neutrophil granule peptides from human leukemic cells. (1991) (28)
- The Importance of Biological Databases in Biological Discovery (2003) (28)
- Allogeneic tumor cells expressing fusogenic membrane glycoproteins as a platform for clinical cancer immunotherapy. (2006) (27)
- Expression of TBX2 promotes anchorage-independent growth and survival in the p53-negative SW13 adrenocortical carcinoma. (2009) (25)
- RK-2: A Novel Rabbit Kidney Defensin and Its Implications for Renal Host Defense (1998) (24)
- Heat shock protein derived from a non‐autologous tumour can be used as an anti‐tumour vaccine (2003) (24)
- alpha-MSH and zona glomerulosa function in the rat. (1983) (24)
- How to use the MEROPS database and website to help understand peptidase specificity (2020) (24)
- Bacterial retrons encode phage-defending tripartite toxin–antitoxin systems (2022) (23)
- Enhanced protein domain discovery using taxonomy (2004) (23)
- Searching databases to find protein domain organization. (2000) (23)
- The Characterisation of Three Types of Genes that Overlie Copy Number Variable Regions (2011) (22)
- Time to underpin Wikipedia wisdom (2010) (22)
- CASP2 knowledge‐based approach to distant homology recognition and fold prediction in CASP4 (2001) (22)
- Outline structures for the extracellular domains of the fibroblast growth factor receptors (1995) (22)
- Tandem domain swapping: determinants of multidomain protein misfolding (2019) (21)
- Human monocyte-derived suppressor cells control graft-versus-host disease by inducing regulatory forkhead box protein 3-positive CD8+ T lymphocytes. (2015) (21)
- Origins of peptidases (2019) (20)
- Corticostatins/defensins inhibit in vitro NK activity and cytokine production by human peripheral blood mononuclear cells (1996) (19)
- The effect of HP-1 and related neutrophil granule peptides on DNA synthesis in HL60 cells (1991) (18)
- Domain atrophy creates rare cases of functional partial protein domains (2015) (18)
- The yeast noncoding RNA interaction network (2017) (18)
- Isolation and characterization of three forms of joining peptide from adult human pituitaries: lack of adrenal androgen-stimulating activity. (1991) (17)
- Aspartimide formation in the joining peptide sequence of porcine and mouse pro-opiomelanocortin. (1993) (16)
- Patterns of database citation in articles and patents indicate long-term scientific and industry value of biological data resources (2016) (16)
- Ten simple rules to make your computing more environmentally sustainable (2021) (16)
- Every Spider Web Has a Simple Flat Twist Tessellation (2011) (16)
- Acetylation of Surface Carbohydrates in Bacterial Pathogens Requires Coordinated Action of a Two-Domain Membrane-Bound Acyltransferase (2020) (16)
- Key challenges for the creation and maintenance of specialist protein resources (2015) (15)
- Sequence analysis of tyrosine recombinases allows annotation of mobile genetic elements in prokaryotic genomes (2021) (15)
- Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS (2017) (15)
- Folding the unfoldable: using AlphaFold to explore spurious proteins (2022) (15)
- InterPro in 2011: new developments in the family and domain prediction database (2012) (14)
- The actions of N-terminal fragments of corticotrophin on steroidogenesis in dispersed rat adrenal cells in vitro. (1986) (14)
- A home for RNA families at RNA Biology (2009) (14)
- RNAcentral: a hub of information for non-coding RNA sequences (2018) (14)
- Corticostatic peptides (1991) (13)
- Computer Tools and Algorithms for Origami Tessellation Design (2002) (13)
- Purification of cationic cystine-rich peptides from rat bone marrow. Primary structures and biological activity of the rat corticostatin family of peptides (1992) (12)
- Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection (2019) (12)
- Recent advances in biocuration: Meeting Report from the fifth International Biocuration Conference (2012) (12)
- Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum (2019) (11)
- Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk (2012) (11)
- Periscope Proteins are variable-length regulators of bacterial cell surface interactions (2020) (11)
- The Expanding Field of Hypothalamic‐Pituitary‐Adrenal Modulation of Human Natural Killer Cell Activity a (1994) (11)
- α-MSH analogues and adrenal zona glomerulosa function (1984) (11)
- The Glycoprotein Growth Factor Progranulin Promotes Carcinogenesis and has Potential Value in Anti-cancer Therapy (2012) (11)
- Progranulin and the receptor tyrosine kinase EphA2, partners in crime? (2016) (10)
- Cancer gene therapy: Part 1. Vector development and regulation of gene expression. (2002) (10)
- Gene Unprediction with Spurio: A tool to identify spurious protein sequences (2018) (9)
- A comparison of Pfam and MEROPS: Two databases, one comprehensive, and one specialised. (2003) (9)
- The structure of pyogenecin immunity protein, a novel bacteriocin-like immunity protein from Streptococcus pyogenes (2009) (9)
- Growing a tumor stroma: a role for granulin and the bone marrow. (2011) (9)
- Reciprocal best structure hits: using AlphaFold models to discover distant homologues (2022) (9)
- Finger rings should be removed prior to scrubbing. (2006) (9)
- Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat (2015) (8)
- Protein Families: Relating Protein Sequence, Structure, and Function (2014) (8)
- The Human RNA-Binding Proteome and Its Dynamics During Arsenite-Induced Translational Arrest (2018) (8)
- The European Bioinformatics Institute (EMBL-EBI) in 2021 (2021) (8)
- Cancer gene therapy: Part 2. Candidate transgenes and their clinical development. (2002) (8)
- Progranulin protects against the tissue damage of acute ischaemic stroke. (2015) (8)
- 0 The Tree Method of Origami Design (8)
- Increasing the Impact of Bioinformatics (2005) (7)
- Non-ACTH components of adult human pituitary extracts which stimulate adrenal steroidogenesis (1986) (7)
- Bioinformatics - The new home for protein sequence motifs (2006) (6)
- Sequence analysis allows functional annotation of tyrosine recombinases in prokaryotic genomes (2019) (6)
- ISCB Computational Biology Wikipedia Competition (2013) (6)
- LUD, a new protein domain associated with lactate utilization (2013) (6)
- The SHOCT Domain: A Widespread Domain Under-Represented in Model Organisms (2013) (5)
- The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator (2009) (5)
- Structural genomics meets computational biology (2006) (5)
- On expert curation and sustainability: UniProtKB/Swiss-Prot as a case study (2016) (5)
- Ten Simple Rules for Chairing a Scientific Session (2009) (4)
- Discovery of fibrillar adhesins across bacterial species (2020) (4)
- Crowdsourcing Protein Family Database Curation (2016) (4)
- TADOSS: computational estimation of tandem domain swap stability (2018) (4)
- Caenorhabditis elegans AF4/FMR2 Family Homolog affl-2 Regulates Heat-Shock-Induced Gene Expression (2020) (4)
- Database Commons: A Catalog of Worldwide Biological Databases. (2022) (3)
- Frontiers in Computational Genomics (2003) (3)
- Structure dissection of zebrafish progranulins identifies a well‐folded granulin/epithelin module protein with pro‐cell survival activities (2018) (3)
- Division of labour in a matrix, rather than phagocytosis or endosymbiosis, as a route for the origin of eukaryotic cells (2020) (3)
- Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states (2021) (3)
- Multiple Molecular Pathways Are Influenced by Progranulin in a Neuronal Cell Model–A Parallel Omics Approach (2022) (3)
- Dendritic cells for the immunotherapy of cancer. (2002) (3)
- The thrombospondin module 1 domain of the matricellular protein CCN3 shows an atypical disulfide pattern and incomplete CWR layers. (2020) (3)
- The YARHG Domain: An Extracellular Domain in Search of a Function (2012) (3)
- A roadmap for the functional annotation of protein families: a community perspective (2022) (3)
- Large-Scale Discovery of Microbial Fibrillar Adhesins and Identification of Novel Members of Adhesive Domain Families (2021) (3)
- Two Pfam protein families characterized by a crystal structure of protein lpg2210 from Legionella pneumophila (2013) (3)
- Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects (2021) (2)
- Effects of CRH, ACTH and the corticostatin HP-4 on the spontaneous NK cell activity and susceptibility to endogenous modifiers. (1992) (2)
- Chromatographic Methods for the Purification of Granulin Peptides. (2018) (2)
- New Leadership for Bioinformatics (2004) (2)
- Rapid identification of novel protein families using similarity searches (2018) (2)
- Discovery of fibrillar adhesins across bacterial species (2021) (2)
- Exploring Non‐Coding RNAs in RNAcentral (2020) (2)
- Methods to Investigate the Roles of Progranulin in Angiogenesis Using In Vitro Strategies and Transgenic Mouse Models. (2018) (2)
- Editorial (2009) (1)
- Editorial (2004) (1)
- Thrombospondin module 1 domain (TSP1) of the matricellular protein CCN3 shows an atypical disulfide pattern and incomplete CWR layers (2019) (1)
- Fusogeneic Membrane Glycoproteins for Cancer Gene Therapy (2005) (1)
- FAIR adoption, assessment and challenges at UniProt (2019) (1)
- DATABASE, The Journal of Biological Databases and Curation, is now the official journal of the International Society for Biocuration (2013) (1)
- Editorial (2014) (1)
- Two Pfam protein families characterized by a crystal structure of protein lpg2210 from Legionella pneumophila (2013) (1)
- Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis (2014) (1)
- Software patents in Bioinformatics (2006) (1)
- PLOS Biology 2016 Reviewer and Editorial Board Thank You (2017) (1)
- LUD, a new protein domain associated with lactate utilization (2013) (1)
- Creating a specialist protein resource network (2015) (1)
- Growth Genes for the Local and Immune-mediated Control of Tumor Fusogenic Membrane Glycoproteins As a Novel Class of Updated (2000) (1)
- ISMB 2014 Proceedings Papers Committee (2014) (1)
- Structure of the $\textit{Escherichia coli}$ ProQ RNA chaperone protein (2017) (1)
- Sequence Classification of Protein Families: Pfam and other Resources (2013) (1)
- Filling out the structural map of the NTF2-like superfamily (2013) (1)
- DPCfam: Unsupervised protein family classification by Density Peak Clustering of large sequence datasets (2022) (1)
- [In vitro effects of peptides of the corticostatin/defensin family on production of mitogen-induced cytokines]. (1995) (1)
- EMBL’s European Bioinformatics Institute (EMBL-EBI) in 2022 (2022) (1)
- Expanding the repertoire of human tandem repeat RNA-binding proteins (2022) (0)
- LYSM Domain from E.coli MLTD (2000) (0)
- Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling (2013) (0)
- The Gene Ontology knowledgebase in 2023 (2023) (0)
- What is hidden in the darkness? Deep-learning assisted large-scale protein family curation uncovers novel protein families and folds (2023) (0)
- Table of Contents (1996) (0)
- InterPro - prediction of protein families, domains and functional sites. (2004) (0)
- Broadening Pfam Protein Sequence Annotations (2009) (0)
- Role of acid-sensitive two-pore domain potassium (K2P) channels in cancer progression (2012) (0)
- a Nitric Oxide-Dependent Mechanism Dendritic Cells Trigger Tumor Cell Death by (2013) (0)
- Caenorhabditis elegans AF4/FMR2 family homolog affl-2 is required for heat shock induced gene expression (2019) (0)
- Abstract 88: Comparative tumorigenesis of progranulin and fibroblast growth factor 4 and in adrenocortical carcinoma cells. (2013) (0)
- Editorial (2008) (0)
- PROTEIN FAMILIES WILEY SERIES ON PROTEIN AND PEPTIDE SCIENCE (2013) (0)
- PROTEIN FAMILIES WILEY SERIES ON PROTEIN AND PEPTIDE SCIENCE (2013) (0)
- Here we show that the C. elegans gene egl-27 encodes a protein similar to MTA1, a component of a protein complex with ATP-dependent nucleosome remodelling and histone deacetylation (1999) (0)
- EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling (2022) (0)
- Pfam families and clans: maximizing biocuration effort (2017) (0)
- Literature and its referents : Analyzing PubMed citations across PFAM (2002) (0)
- Editorial (2007) (0)
- ISMB 2010 Organization (2010) (0)
- Characterization of granulins, a novel family of cysteine rich growth modulating peptides (1994) (0)
- Domain atrophy creates rare cases of functional partial protein domains (2015) (0)
- Title : Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity Running Title : Eros-a novel protein essential for innate immunity (2017) (0)
- Methods for Expression and Purification of Biologically Active Recombinant Progranulin. (2018) (0)
- Structure of Rib domain 'Rib Long' from Lactobacillus acidophilus (2019) (0)
- ISMB 2016 Proceedings Papers Committee (2016) (0)
- Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis (2014) (0)
- Structure of Rib Standard, a Rib domain from Lactobacillus acidophilus (2019) (0)
- Structure of the C-terminal domain of the Escherichia Coli ProQ RNA binding protein (2017) (0)
- Building non-coding RNA networks in IntAct (2018) (0)
- An update from the Bioinformatics Editors (2005) (0)
- Role of Eros, a novel transmembrane protein, in regulation of host defence (2016) (0)
- Structure of RibR, the most N-terminal Rib domain from Group B Streptococcus species Streptococcus agalactiae (2019) (0)
- Bioinformatics Advance Access published May 31, 2007 (2007) (0)
- The challenge of increasing Pfam coverage of the human proteome (2013) (0)
- Tissue-specific rewiring of signalling pathways through alternatively spliced disordered segments (2010) (0)
- Structure of Rib R28N from Streptococcus pyogenes (2019) (0)
- Editorial (2007) (0)
- Abstract 961: Pathways of tumorigenesis promoted by the growth factor progranulin in SW-13 adrenocortical carcinoma cells (2012) (0)
- UniProt domain architecture alignment: a new approach for protein similarity search using InterPro domain annotation (2014) (0)
- Example domain architectures of PPC-containing proteins (2011) (0)
- Precursors to Enhance Antigen Uptake and Targets Immature Dendritic Cell Tumor Cell Killing Induces Th1 Cytokines Heat Shock Protein 70 Induced During (1999) (0)
- RESERVE A 4-BEDROOM AT GRANBY MILL FOR FALL 2018 AND GET A FREE FLAT SCREEN TV ! * (2019) (0)
- Andrew Bateman in Vivo and Promotes Tumor Growth Gene Expression Regulates Epithelial Cell Growth Progranulin Updated (1999) (0)
- Structure of tandemly arrayed consecutive Rib domains (Rib2R) from Group B Streptococcal species Streptococcus agalactiae (2019) (0)
- A phenotype for breast cancer arising in the Li Fraumeni Syndrome (2009) (0)
- Division of labour in a matrix, rather than phagocytosis or endosymbiosis, as a route for the origin of eukaryotic cells (2020) (0)
- [The autocrine-paracrine modulation of natural killer activity in man by peptides of the corticostatin-defensin family]. (1993) (0)
- EDITORIAL (2005) (0)
- Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains ( epithelin / growth factors / kidney / i ion ) (2004) (0)
- Granulins: A New Family of Peptides from Inflammatory Cells, (1992) (0)
- Editorial (2020) (0)
- alpha-MSH analogues and adrenal zona glomerulosa function. (1984) (0)
- Modelling structural rearrangements in proteins using Euclidean distance matrices (2020) (0)
- Fusogenic membrane glycoproteins - A novel class of cytotoxic genes with immunostimulatory properties. (1999) (0)
- SPATIAL-TEMPORAL ANALYSIS OF PROGRANULIN EXPRESSION IN PIG PERI-OVULATORY FOLLICLES AND CORPUS LUTEUM (2007) (0)
- PROGRANULIN IS EXPRESSED DURING MINK EMBRYO IMPLANTATION AND PLACENTA FORMATION (2007) (0)
- Ismb/eccb 2019 Proceedings Papers Committee (2019) (0)
- TMEM106B, an unexpected point of contact between FTD, ageing and a hypomyelination disorder. (2020) (0)
- Domain shuffling of a highly mutable ligand binding fold drives adhesin generation across the bacterial kingdom. (2023) (0)
- This information is current as Action Secretion from Mast Cells : Mechanisms of Neutrophil Defensins Induce Histamine (1999) (0)
- Abstract B91: A novel role for the secreted growth factor progranulin in angiogenesis (2013) (0)
- A. Bateman, et al, Cancer Res., 60: 2492–2497, 2000. (2000) (0)
- Targeting the cytotoxicity of a fusogenic gibbon ape leukaemia virus envelope glycoprotein by ligand display. (1999) (0)
- Exon classification Constitutive exons Other Cassette exons Tissue-specific Cassette exons Characterization of the encoded protein segments Brain (2012) (0)
- Dendritic cells in cancer immunotherapy (1999) (0)
- Checklist for the perfect spring break (2019) (0)
- Acknowledgment of Reviewers for 2011 (2012) (0)
- Structural insights into the transposition of antibiotic resistance (2021) (0)
- Structure and function of DNA transposition assemblies involved in antibiotic resistance spreading (2022) (0)
- THE IMPORTANCE OF S-PALMITOYLATION IN TUMORIGENESIS Summary (2017) (0)
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