Alex K. Shalek
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Physics Biology
Alex K. Shalek's Degrees
- PhD Physics Stanford University
- Bachelors Physics Stanford University
Why Is Alex K. Shalek Influential?
(Suggest an Edit or Addition)According to Wikipedia, Alex K. Shalek is a biomedical engineer, and a core faculty member of the Institute for Medical Engineering and Science , an Associate Professor of Chemistry, and an Extramural Member of the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology. Additionally, he is a Member of the Ragon Institute and an Institute Member of the Broad Institute, an Assistant in Immunology at Massachusetts General Hospital, and an Instructor in Health Sciences and Technology at Harvard Medical School. The multi-disciplinary research of the Shalek Lab aims to create and implement broadly-applicable methods to study and engineer cellular responses in tissues, to drive biological discovery and improve prognostics, diagnostics, and therapeutics for autoimmune, infectious, and cancerous diseases. Shalek and his lab are best known for their work in single-cell genomics and for studying a number of devastating, but difficult to study, human diseases with partners around the world.
Alex K. Shalek's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets (2015) (5020)
- Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma (2014) (3192)
- Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq (2016) (2825)
- SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues (2020) (1833)
- SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues (2020) (1833)
- SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes (2020) (1723)
- MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data (2015) (1584)
- The Human Cell Atlas (2017) (1285)
- Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells (2013) (1096)
- Single cell RNA Seq reveals dynamic paracrine control of cellular variation (2014) (848)
- Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells (2014) (712)
- Dynamic regulatory network controlling Th17 cell differentiation (2013) (626)
- Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells (2010) (523)
- Vertical nanowire electrode arrays as a scalable platform for intracellular interfacing to neuronal circuits. (2012) (503)
- Whole exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer (2014) (479)
- Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity (2015) (460)
- Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity (2019) (460)
- Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput (2017) (426)
- Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells (2013) (409)
- Systematic comparison of single-cell and single-nucleus RNA-sequencing methods (2020) (368)
- COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets (2021) (347)
- Deconstructing transcriptional heterogeneity in pluripotent stem cells (2014) (335)
- Prevention of tuberculosis in macaques after intravenous BCG immunization (2020) (279)
- Allergic inflammatory memory in human respiratory epithelial progenitor cells (2018) (270)
- Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices (2017) (238)
- The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution (2020) (234)
- The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution (2020) (234)
- Preparation of Single‐Cell RNA‐Seq Libraries for Next Generation Sequencing (2014) (225)
- Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19 (2020) (205)
- Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM (2016) (191)
- Seq-Well: A Portable, Low-Cost Platform for High-Throughput Single-Cell RNA-Seq of Low-Input Samples (2017) (184)
- Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits (2011) (182)
- Nanowire-Mediated Delivery Enables Functional Interrogation of Primary Immune Cells: Application to the Analysis of Chronic Lymphocytic Leukemia (2012) (165)
- Heterogeneity in immune responses: from populations to single cells. (2014) (152)
- Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration (2019) (144)
- Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses (2015) (138)
- Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration. (2019) (137)
- Identification of a Master Regulator of Differentiation in Toxoplasma (2019) (130)
- IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment (2017) (129)
- Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction (2016) (125)
- A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages (2016) (122)
- Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression. (2016) (117)
- Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis (2019) (116)
- Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells (2017) (114)
- Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies (2020) (106)
- Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses (2015) (105)
- Single-cell analyses to tailor treatments (2017) (105)
- Probing enzymatic activity inside living cells using a nanowire-cell "sandwich" assay. (2013) (101)
- Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19 (2021) (97)
- Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer (2021) (95)
- Systematic comparative analysis of single cell RNA-sequencing methods (2019) (93)
- Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease. (2020) (83)
- Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection (2019) (72)
- Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL. (2012) (71)
- Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19 (2021) (67)
- Erratum: Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput (2017) (67)
- Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases (2020) (66)
- TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures (2019) (65)
- A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases (2019) (60)
- Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential (2020) (58)
- Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus. (2019) (56)
- The Human Cell Atlas White Paper (2018) (55)
- Computational Methods for Single-Cell RNA Sequencing (2020) (53)
- Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas (2021) (51)
- Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion (2016) (49)
- Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity (2020) (47)
- Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics (2020) (47)
- Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses (2018) (46)
- Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2 (2021) (46)
- High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity (2021) (46)
- Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection (2019) (46)
- Circulating CXCR5+CXCR3+PD-1lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth. (2017) (44)
- Oct1 and OCA-B are selectively required for CD4 memory T cell function (2015) (44)
- Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli (2013) (42)
- Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation (2021) (42)
- Highly Efficient, Massively-Parallel Single-Cell RNA-Seq Reveals Cellular States and Molecular Features of Human Skin Pathology (2019) (42)
- Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types (2018) (41)
- The cellular architecture of the antimicrobial response network in human leprosy granulomas (2020) (40)
- Linking single-cell measurements of mass, growth rate, and gene expression (2018) (39)
- Expression of Foxp3 by T follicular helper cells in end-stage germinal centers (2021) (38)
- Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer (2019) (38)
- Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control (2022) (37)
- A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers (2018) (37)
- Regulation of X-linked gene expression during early mouse development by Rlim (2016) (34)
- Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states (2020) (34)
- Distribution and storage of inflammatory memory in barrier tissues (2020) (30)
- A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2 (2021) (30)
- Single cell profiling of COVID-19 patients: an international data resource from multiple tissues (2020) (30)
- Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells (2019) (30)
- IL-5Rα marks nasal polyp IgG4 and IgE-expressing cells in aspirin-exacerbated respiratory disease. (2020) (29)
- Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells (2020) (25)
- Functional compensation precedes recovery of tissue mass following acute liver injury (2020) (25)
- SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes (2020) (24)
- Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease (2021) (23)
- Induction of metabolic quiescence defines the transitional to follicular B cell switch (2019) (23)
- Evolution and Diversity of Immune Responses during Acute HIV Infection. (2020) (22)
- Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients (2021) (22)
- Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents. (2019) (21)
- Seq-Well: A Sample-Efficient, Portable Picowell Platform for Massively Parallel Single-Cell RNA Sequencing. (2019) (21)
- Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity (2021) (21)
- Phase II study of pembrolizumab in leptomeningeal carcinomatosis. (2018) (20)
- Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip (2021) (20)
- Immunological Fingerprints of Controllers Developing Neutralizing HIV-1 Antibodies (2020) (19)
- Rewiring of the cellular and inter-cellular landscape of the human colon during ulcerative colitis (2018) (19)
- High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults (2018) (18)
- A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood (2020) (17)
- Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults (2020) (16)
- Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage (2021) (15)
- Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes (2021) (14)
- Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases (2021) (13)
- Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease (2020) (13)
- Photoinduced interfacial charging and "explosion" of monolayer pentacene islands. (2005) (13)
- A single-cell liver atlas of Plasmodium vivax infection. (2022) (13)
- Deciphering the immunopeptidome in vivo reveals new tumour antigens (2022) (12)
- Patel glioblastoma Single-cell RNA-seq highlights intratumoral heterogeneity in primary (2014) (12)
- Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8+ T cell repertoire upon viral exposure (2021) (12)
- Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice (2020) (12)
- A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery (2021) (11)
- Improved haplotype inference by exploiting long-range linking and allelic imbalance in RNA-seq datasets (2020) (11)
- Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease. (2021) (11)
- Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation (2022) (11)
- Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control (2021) (11)
- Author response: The Human Cell Atlas (2017) (10)
- Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies (2017) (10)
- Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control (2020) (9)
- Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states (2022) (8)
- Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression (2019) (8)
- Transcriptional subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer (2020) (8)
- Correction: Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies (2017) (7)
- Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response (2021) (7)
- PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment (2022) (7)
- MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection (2020) (7)
- Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu (2020) (7)
- HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells (2021) (6)
- The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer (2020) (6)
- Single-cell profiling of Ebola virus infection in vivo reveals viral and host transcriptional dynamics (2020) (6)
- Systematic comparison of single-cell and single-nucleus RNA-sequencing methods (2020) (6)
- Voices in methods development (2019) (6)
- Cellular and transcriptional diversity over the course of human lactation (2021) (6)
- Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation in severe disease (2021) (6)
- Revisiting Airway Epithelial Remodeling in Type 2 Immunity: Beyond Goblet Cell Metaplasia. (2019) (5)
- Author Correction: Systematic comparison of single-cell and single-nucleus RNA-sequencing methods (2020) (5)
- MERFISHing for spatial context. (2015) (5)
- Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity (2021) (5)
- JAK inhibition in a patient with a STAT1 gain-of-function variant reveals STAT1 dysregulation as a common feature of aplastic anemia. (2022) (5)
- The Human Cell Atlas and equity: lessons learned (2020) (5)
- Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy (2020) (4)
- T helper cells modulate intestinal stem cell renewal and differentiation (2017) (4)
- Identification and Tracking of Alloreactive T Cell Clones in Rhesus Macaques Through the RM-scTCR-Seq Platform (2021) (4)
- Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells (2021) (4)
- Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics (2015) (3)
- Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm (2021) (3)
- High-throughput organoid screening enables engineering of intestinal epithelial composition (2020) (3)
- Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation (2022) (3)
- Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated in vitro follicle growth system (2021) (3)
- Comparative analysis of cell-cell communication at single-cell resolution (2022) (3)
- Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells (2022) (3)
- Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation (2022) (3)
- Abstract CN07-04: Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq (2015) (3)
- Sensory Neurons Innervate Peripheral Lymph Nodes and Locally Regulate Gene Expression in Postsynaptic Endothelium, Stromal Cells, and Innate Leukocytes (2019) (2)
- Vertical nanowire electrode array: a highly scalable platform for intracellular interfacing to neuronal circuits (2012) (2)
- Single-cell Genomics using Droplet-based Microfluidics (2014) (2)
- Abstract 993: Whole exome sequencing of CTCs as a window into metastatic cancer (2014) (2)
- IL-5Rα marks nasal polyp IgG4 and IgE-secreting cells in aspirin-exacerbated respiratory disease (2019) (2)
- Single-cell analysis uncovers mechanisms of plasticity in leukemia initiating cells (2020) (2)
- Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation (2022) (2)
- Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunity (2017) (2)
- A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers (2018) (2)
- Gene signatures and host-parasite interactions revealed by dual single-cell profiling of Plasmodium vivax liver infection (2021) (2)
- Correction to: A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases (2020) (2)
- Spatially-Resolved Live Cell Tagging and Isolation Using Protected Photoactivatable Cell Dyes (2020) (1)
- An N-of-1 Trial of Itacitinib for a Patient with Aplastic Anemia Associated with a Gain-of-Function Variant in STAT1 (2021) (1)
- Single cell biology—a Keystone Symposia report (2021) (1)
- Abstract PO-058: Transcriptional subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer (2020) (1)
- Enriching and Characterizing T Cell Repertoires from 3' Barcoded Single-Cell Whole Transcriptome Amplification Products. (2022) (1)
- Abstract AP19: SINGLE–CELL RNA–SEQUENCING OF PATIENT–DERIVED OVARIAN CANCER CELLS AND PATIENT–DERIVED XENOGRAFT MODELS (2017) (1)
- Author Correction: Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases (2021) (1)
- Author response: Regulation of X-linked gene expression during early mouse development by Rlim (2016) (1)
- A Treatment-Naive Cellular Atlas of Pediatric Crohn's Disease Predicts Disease Severity and Therapeutic Response (2021) (1)
- Deciphering the tumor-specific immunopeptidome in vivo with genetically engineered mouse models (2021) (1)
- Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics (2021) (1)
- Unlocking mast cell diversity in human nasal polyps (2017) (1)
- Linking single-cell measurements of mass, growth rate, and gene expression (2018) (1)
- Circulating CXCR5[superscript +]CXCR3[superscript +]PD-1[superscript lo] Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth (2017) (1)
- Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection (2020) (1)
- PI3Kβ controls immune evasion in PTEN-deficient breast tumours (2023) (1)
- Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis) (2022) (1)
- How to ensure the Human Cell Atlas benefits humanity (2022) (1)
- Abstract 4380: Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-sequencing (2016) (1)
- A basic strategy for detecting CD8 T cell specificity (2016) (1)
- Sensitivity to Wnt Pathway Inhibition in CLL Is Associated with Specific Gene Expression Signatures (2011) (1)
- Mechanisms of Leukemia Stem Cell Plasticity Revealed By Single Cell Analysis (2020) (1)
- CMET-20. EVIDENCE OF CNS RESPONSE OF PEMBROLIZUMAB FOR LEPTOMENINGEAL CARCINOMATOSIS AT A SINGLE CELL RESOLUTION (2018) (1)
- A human liver cell-based system modeling a clinical prognostic liver signature combined with single cell RNA-seq for discovery of novel liver disease therapeutics (2020) (1)
- MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data (2015) (0)
- Spatially-resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intra-tumoral heterogeneity. (2022) (0)
- Recovery of Paired T Cell Receptors from Single-cell Seq-Well Libraries (2019) (0)
- Abstract IA007: Does cancer cell state matter? Moving from DNA genotype to RNA phenotype-directed therapies in cancer (2022) (0)
- Cancer tissue of origin constrains the growth and metabolism of metastases (2022) (0)
- Erratum: Deconstructing transcriptional heterogeneity in pluripotent stem cells (2015) (0)
- Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction (2016) (0)
- Abstract PR15: Assessment of tumor heterogeneity, clonal evolution, and the stromal microenvironment in metastatic pancreatic ductal adenocarcinoma and matched patient-derived organoids (2019) (0)
- CAR-T Cell Infusion Results in Activation of CD160+/NKG2D+/CCL5+ Non-CAR CD8+ Cytotoxic 'Bystander' T Cells in Both Non-Human Primates (NHP) and Patients Receiving B-Cell-Directed CAR-Ts (2022) (0)
- LGG-05. SINGLE-CELL RNA SEQUENCING OF PEDIATRIC LOW-GRADE GLIOMAS REVEALS INTRATUMORAL HETEROGENEITY. (2017) (0)
- 150 – Single-Cell Analysis of T Cell Pathogenesis in Pediatric Crohn's Disease (2019) (0)
- Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states (2020) (0)
- Abstract IA20: Aberrant leukemic developmental hierarchies and MRD-specific targeting informed by single-cell biophysical and molecular profiling (2020) (0)
- 3126 – SINGLE CELL SEQUENCING OF MLL-REARRANGED LEUKEMIA REVEALS MECHANISMS OF LEUKEMIA INITIATING CELL PLASTICITY (2020) (0)
- 317 CYTOF ANALYSIS OF HUMAN COLON AND BLOOD REVEALS DISTINCT IMMUNE SIGNATURES OF ULCERATIVE COLITIS AND CROHN'S DISEASE (2020) (0)
- Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis (2019) (0)
- Non-human primate derived CD20 CAR T cells elicit a bystander effect on CD8 but not CD4 car negative T cells (2021) (0)
- LGG-13. RESOLVING TRANSCRIPTIONAL PROFILES IN BRAF-REARRANGED PILOCYTIC ASTROCYTOMA USING SINGLE CELL RNA SEQUENCING (2018) (0)
- Abstract 3027: Dissecting mechanisms of anti-PD-1 therapy with massively parallel single-cell RNA-sequencing (2017) (0)
- Abstract PR03: Subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer (2020) (0)
- GM-CSF differentiation of human monocytes stabilizes macrophage state via oxidative signaling (2020) (0)
- Cell Mass and Stiffness As Integrative Biomarkers of Cell State in Mantle Cell Lymphoma (2022) (0)
- Single-cell RNA-sequencing of leprosy skin lesions reveals a titin (TTN) expressing T cell subset associated with the progressive disease (2020) (0)
- Size no longer matters (2016) (0)
- Severe COVID-19 is associated with fungal colonization of the nasopharynx and potent induction of IL-17 responses in the nasal epithelium (2022) (0)
- Lymph Node Innate Lymphoid Cells (ILCs) in HIV Infected Children are Highly Activated Despite Sustained Depletion in Blood (2019) (0)
- A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients (2022) (0)
- 570 A genome-wide association study in an African American cohort implicates IL-12A in acne (2021) (0)
- Made-by-measure (2016) (0)
- Single-Cell Analysis of AML Reveals Determinants of Disease Progression and Immune Evasion (2018) (0)
- Baring cellular souls (2017) (0)
- Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types (2018) (0)
- Speed kills (2016) (0)
- Implementation of single-cell genomics as a translational tool in patients with metastatic melanoma. (2016) (0)
- Profiling Transcriptional Heterogeneity with Seq-Well S3: A Low-Cost, Portable, High-Fidelity Platform for Massively Parallel Single-Cell RNA-Seq. (2023) (0)
- HIV-specific CD8+ T-cells in tonsils express exhaustive TRM-like signatures (2021) (0)
- A Comparative Look at Structure-Function Roles in Light-Harvesting Dynamics of Purple Bacteria (2020) (0)
- Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation (2023) (0)
- Abstract PR02: Matched metastatic pancreatic ductal adenocarcinoma biopsies and organoid models reveal tumor cell transcriptional plasticity and subtype-specific microenvironmental crosstalk (2020) (0)
- Zika meets its match (2016) (0)
- Tobacco smoke exposure results in recruitment of inflammatory airspace monocytes and accelerated growth of Mycobacterium tuberculosis (2022) (0)
- A case of mistaken identity (2017) (0)
- Abstract 2450: Single-cell profiling reveals programs mediating oncogenic kinase-independence and minimal residual disease in BCR-ABL-rearranged acute lymphoblastic leukemia (2019) (0)
- Single Cell RNA‐sequencing (scRNA‐seq) Reveals Reprogramming and Functional Compensation Preceding Cellular Recovery in Multiple Models of Acute Liver Injury (2019) (0)
- Distribution and storage of inflammatory memory in barrier tissues (2020) (0)
- #33: Single-cell RNA sequencing analysis of Zika virus infection in human stem cell-derived neuroprogenitor cells and cerebral organoids (2021) (0)
- Clinical Implementation of Single-Cell RNA Sequencing Using Liver Fine Needle Aspirate Tissuesampling and Centralized Processing Captures Compartment Specific Immuno-Diversity (2021) (0)
- Mast cell hyperplasia in human type 2 inflammation: insights from single cell RNA sequencing: 543 (2019) (0)
- Compressed phenotypic screens for complex multicellular models and high-content assays (2023) (0)
- 399 PROTEOMIC AND TRANSCRIPTOMIC ANALYSIS OF VERY EARLY ONSET IBD MUCOSA ACROSS INTERNATIONAL SITES REVEALS PATIENTSPECIFIC INFLAMMATORY CELLULAR SIGNATURES (2020) (0)
- Characterizing the T cell receptor clonotype repertoire of an atypical HLA class II-restricted CD8 T cell response in HIV-1 infection (VIR6P.1170) (2015) (0)
- 973. Single-cell RNA Sequencing Analysis of Zika Virus Infection in Human Stem Cell-Derived Cerebral Organoids (2019) (0)
- On the right track (2016) (0)
- Single-Cell RNA-Seq Reveals AML Cellular Hierarchies Relevant to Clinical Outcomes and Immunity (2018) (0)
- Allergic inflammatory memory in human respiratory epithelial progenitor cells (2018) (0)
- #71: Single-cell RNA Sequencing Analysis of Zika Virus Infection in Human Stem Cell-Derived Neuroprogenitor Cells and Cerebral Organoids (2021) (0)
- Temporal patterns in single cell immune profile of tuberculosis lung granulomas (2020) (0)
- Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults [preprint] (2020) (0)
- Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis (2019) (0)
- 065 Highly conserved tissue immune signatures are co-opted in cancer (2017) (0)
- Prevention of tuberculosis in macaques after intravenous BCG immunization (2020) (0)
- Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics (2015) (0)
- A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases (2019) (0)
- Deciphering multicellular microenvironment of tuberculosis lung granulomas associated with bacterial control using high-throughput single-cell mRNA sequencing (2019) (0)
- Single-Cell RNA-Seq Allows Deep Analysis of the Tumor Immune Microenvironment and Alterations Induced by Anti-PD-1 Treatment (2016) (0)
- LGG-05. SINGLE CELL RNA SEQUENCING REVEALS MITOGENIC AND PROGENITOR GENE PROGRAMS IN BRAF-REARRANGED PILOCYTIC ASTROCYTOMAS (2019) (0)
- Abstract PR11: Dissecting mechanisms of PD-1 blockade with single-cell RNA-sequencing (2017) (0)
- Integrating endometrial proteomic and single cell transcriptomic pipelines reveals distinct menstrual cycle and endometriosis-associated molecular profiles (2022) (0)
- An ex vivo ovulation system enables the discovery of novel ovulatory pathways and nonhormonal contraceptive candidates (2023) (0)
- P154 SINGLE-CELL ANALYSIS OF T CELL PATHOGENESIS IN PEDIATRIC CROHN’S DISEASE (2019) (0)
- HIV infection is associated with preservation of MAIT cells in the lungs but alteration of their phenotype and T cell receptor repertoire (2016) (0)
- Abstract A082: Single-cell RNA-sequencing of metastatic melanoma identifies a cancer cell-intrinsic program associated with immune checkpoint inhibitor resistance (2019) (0)
- Defining the role of CD8 T cell subsets in tuberculosis in non-human primates (2020) (0)
- 2001 – PLASTICITY OF B-LYMPHOBLASTIC LEUKEMIA STEM CELLS (2021) (0)
- Title : IL-5 Rα marks nasal polyp IgG 4 and IgE-secreting cells in aspirin-exacerbated respiratory disease (2019) (0)
- Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection (2023) (0)
- Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses (2018) (0)
- SUPPLEMENTAL METHODS AND EXTENDED DERIVATIONS (2015) (0)
- Author Correction: Systematic comparison of single-cell and single-nucleus RNA-sequencing methods (2020) (0)
- Frequent generation of HIV broadly neutralizing antibodies in infected children is associated with both increased help and regulation within germinal centers (2018) (0)
- Abstract 3647: Single cell RNA sequencing reveals mitogenic and progenitor gene programs inBRAF-rearranged pilocytic astrocytomas (2019) (0)
- Publisher Correction: Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes (2021) (0)
- Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis) (2022) (0)
- Expanding the HDAC druggable landscape beyond enzymatic activity (2023) (0)
- A Single-Cell Liver Atlas of Relapsing Human Malaria (2021) (0)
- NIAID workshop on T cell technologies (2023) (0)
- Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation (2022) (0)
- Single-cell analysis of cellular state heterogeneity in human localized prostate cancer. (2021) (0)
- Resource Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells (2013) (0)
- Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Antitumor Immunity (2020) (0)
- HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control (2022) (0)
- MASTdata: MAST presubmission (2015) (0)
- Seq-Well: A portable, low-cost platform for massively-parallel single-cell RNA-Seq profiling of sparse clinical samples (2017) (0)
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