Alex Sevanian

Q: What Schools Are Affiliated With Alex Sevanian

Alex Sevanian is affiliated with the following schools: University of California, Berkeley, California State University, Northridge, University of Southern California, University of California, Los Angeles, Stanford University, Johns Hopkins University, University of California, San Francisco

Alex Sevanian's AcademicInfluence.com Rankings

Alex Sevanian

Medical

#1300

World Rank

#1626

Historical Rank

Pharmacology

#192

World Rank

#232

Historical Rank

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Medical

Alex Sevanian's Degrees

Bachelors Pharmacology University of California, Berkeley
PhD Pharmacology University of California, San Francisco

Why Is Alex Sevanian Influential?

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According to Wikipedia, Alex Sevanian was an American pharmacologist. Early life and family Sevanian was born in Germany and emigrated to the United States with his family, settling first in San Francisco and later in the San Fernando Valley . Alex Sevanian's father, Ara Sevanian , was a composer and canonist whose works have been performed by the Los Angeles Philharmonic and the Chattanooga Symphony and Opera, among others. Alex Sevanian, with his wife, Diana Lynn Sevanian, had two sons, David Alexander Sevanian and Andrew Maximillian Sevanian.

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Alex Sevanian's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Oxidants as stimulators of signal transduction. (1997) (1398)
Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. (1990) (949)
Nutritional, dietary and postprandial oxidative stress. (2005) (548)
Mechanisms and consequences of lipid peroxidation in biological systems. (1985) (537)
Uric acid-iron ion complexes. A new aspect of the antioxidant functions of uric acid. (1986) (524)
Estrogen in the Prevention of Atherosclerosis (2001) (478)
Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein. (1995) (425)
A new role for phospholipase A2: protection of membranes from lipid peroxidation damage (1987) (423)
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3. (2000) (387)
Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebo-controlled trial. (2001) (370)
Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis. (1995) (340)
Pulsatile Versus Oscillatory Shear Stress Regulates NADPH Oxidase Subunit Expression: Implication for Native LDL Oxidation (2003) (325)
Alpha-Tocopherol Supplementation in Healthy Individuals Reduces Low-Density Lipoprotein Oxidation but Not Atherosclerosis: The Vitamin E Atherosclerosis Prevention Study (VEAPS) (2002) (314)
Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-). (1994) (284)
Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: Evidence for an antiinflammatory role for lipoprotein lipase (2003) (253)
Serum urate as an antioxidant for ascorbic acid. (1991) (241)
The influence of phospholipase A2 and glutathione peroxidase on the elimination of membrane lipid peroxides. (1983) (223)
Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women. (2003) (220)
Lipid oxidation products in cell signaling. (2000) (214)
Hormone Therapy and the Progression of Coronary-Artery Atherosclerosis in Postmenopausal Women (2003) (203)
Phospholipase A2 dependent release of fatty acids from peroxidized membranes. (1985) (200)
Postprandial plasma lipid hydroperoxides: a possible link between diet and atherosclerosis. (1998) (173)
LDL- is a lipid hydroperoxide-enriched circulating lipoprotein. (1997) (169)
Cholesterol feeding increases plasma and aortic tissue cholesterol oxide levels in parallel: further evidence for the role of cholesterol oxidation in atherosclerosis. (1991) (168)
The cytotoxic and mutagenic properties of cholesterol oxidation products. (1986) (168)
Effect of supplementary antioxidant vitamin intake on carotid arterial wall intima-media thickness in a controlled clinical trial of cholesterol lowering. (1996) (161)
Monocyte recruitment to endothelial cells in response to oscillatory shear stress (2003) (157)
Contribution of an in vivo oxidized LDL to LDL oxidation and its association with dense LDL subpopulations. (1996) (154)
Lipid peroxidation-induced membrane structural alterations. (1994) (151)
Lipid peroxidation and phospholipase A2 activity in liposomes composed of unsaturated phospholipids: a structural basis for enzyme activation. (1988) (147)
Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products. (1999) (141)
The phytoestrogen equol increases nitric oxide availability by inhibiting superoxide production: an antioxidant mechanism for cell-mediated LDL modification. (2003) (136)
Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. (2002) (134)
Lipid peroxidation in membranes and low-density lipoproteins: similarities and differences. (2000) (123)
Conservation of vitamin C by uric acid in blood. (1985) (123)
Oxidative Cross-linking of ApoB100 and Hemoglobin Results in Low Density Lipoprotein Modification in Blood (1999) (123)
Role of Lipid Peroxidation in the Epidemiology and Prevention of Breast Cancer (2005) (120)
Characterization of endothelial cell injury by cholesterol oxidation products found in oxidized LDL. (1995) (118)
Characterization of cholesterol oxidation products formed by oxidative modification of low density lipoprotein. (1997) (116)
Copper can promote oxidation of LDL by markedly different mechanisms. (1998) (110)
Cholesterol epoxide is a direct-acting mutagen. (1984) (110)
Synergistic inhibition of LDL oxidation by phytoestrogens and ascorbic acid. (2000) (108)
Superoxide dismutase in ocular structures. (1985) (103)
Effect of uric acid and chemical analogues on oxidation of human low density lipoprotein in vitro. (1998) (100)
Oxysterol mixtures prevent proapoptotic effects of 7‐ ketocholesterol in macrophages: implications for proatherogenic gene modulation (2004) (99)
Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry. (1994) (98)
Microsomal lipid peroxidation: the role of NADPH--cytochrome P450 reductase and cytochrome P450. (1990) (95)
Cardioprotective effects of individual conjugated equine estrogens through their possible modulation of insulin resistance and oxidation of low-density lipoprotein. (1997) (87)
Uptake, metabolism, and cytotoxicity of isomeric cholesterol-5,6-epoxides in rabbit aortic endothelial cells. (1991) (86)
Phospholipid peroxidation induces cytosolic phospholipase A2 activity: membrane effects versus enzyme phosphorylation. (1997) (82)
Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cells. (2005) (81)
Lipid peroxidation in biological systems (1988) (81)
Oxidant stress in hemodialysis: prevention and treatment strategies. (2000) (79)
Immunohistochemical localization of glutathione peroxidase in ocular tissue. (1988) (79)
Soy and alfalfa phytoestrogen extracts become potent low-density lipoprotein antioxidants in the presence of acerola cherry extract. (2001) (78)
Arterial injury by cholesterol oxidation products causes endothelial dysfunction and arterial wall cholesterol accumulation. (1998) (73)
Ferrylmyoglobin-catalyzed linoleic acid peroxidation. (1990) (71)
Up‐regulation of the fibrogenic cytokine TGF‐β1 by oxysterols: a mechanistic link between cholesterol and atherosclerosis (2001) (71)
Role of free radicals in uveitis. (1987) (70)
Loss of apoB-100 secondary structure and conformation in hydroperoxide rich, electronegative LDL(-). (2001) (70)
Immunolocalization of native antioxidant scavenger enzymes in early hypertensive and atherosclerotic arteries. Role of oxygen free radicals. (1992) (70)
Oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine induces vascular endothelial superoxide production: implication of NADPH oxidase. (2005) (69)
Probucol reduces plasma and aortic wall oxysterol levels in cholesterol fed rabbits independently of its plasma cholesterol lowering effect. (1992) (69)
Enhanced interfacial catalysis and hydrolytic specificity of phospholipase A2 toward peroxidized phosphatidylcholine vesicles. (1993) (68)
Atherosclerosis: another protein misfolding disease? (2002) (68)
Dual Roles for Lipolysis and Oxidation in Peroxisome Proliferation-Activator Receptor Responses to Electronegative Low Density Lipoprotein* (2003) (67)
Regulation of Fetal Lung Phosphatidyl Choline Synthesis by Cortisol: Role of Glycogen and Glucose (1977) (66)
Role of Adenosine 3′,5′-Monophosphate in Maturation of Fetal Lungs (1976) (63)
Co-oxidation of salicylate and cholesterol during the oxidation of metmyoglobin by H2O2. (1988) (62)
Optimization of nutrition: polyphenols and vascular protection. (2009) (62)
Oxidized phospholipids mediate occludin expression and phosphorylation in vascular endothelial cells. (2006) (58)
Structural and dynamic effects of oxidatively modified phospholipids in unsaturated lipid membranes. (1992) (58)
Detection of electronegative low density lipoprotein (LDL-) in plasma and atherosclerotic lesions by monoclonal antibody-based immunoassays. (2006) (57)
The effect of vitamin E, probucol, and lovastatin on oxidative status and aortic fatty lesions in hyperlipidemic-diabetic hamsters. (2000) (55)
LDL phospholipid hydrolysis produces modified electronegative particles with an unfolded apoB-100 protein Published, JLR Papers in Press, October 16, 2004. DOI 10.1194/jlr.M400306-JLR200 (2005) (51)
Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes. (2006) (50)
Low Density Lipoprotein (LDL) Modification: Basic Concepts and Relationship to Atherosclerosis (1999) (49)
Lipid hydroperoxide-induced peroxidation and turnover of endothelial cell phospholipids. (1994) (48)
Cholesterol oxides and carcinogenesis (1991) (48)
Linoleic acid hydroperoxide-induced peroxidation of endothelial cell phospholipids and cytotoxicity. (1994) (47)
Cholesterol autoxidation in phospholipid membrane bilayers (1987) (46)
Determinants of the effect of estrogen on the progression of subclinical atherosclerosis: Estrogen in the Prevention of Atherosclerosis Trial (2005) (44)
Cholesterol oxidation products induce vascular foam cell lesion formation in hypercholesterolemic New Zealand white rabbits. (1999) (43)
Histochemical localization of superoxide production in experimental autoimmune uveitis. (1991) (43)
Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase. (1986) (43)
Detection of retinal lipid hydroperoxides in experimental uveitis. (1992) (42)
Inhibition of Surfactant Production by Insulin in Fetal Rabbit Lung Slices (1979) (42)
OxLDL induces macrophage gamma-GCS-HS protein expression: a role for oxLDL-associated lipid hydroperoxide in GSH synthesis. (2001) (41)
Evolution of oxidative stress and inflammation during hemodialysis and their contribution to cardiovascular disease. (2002) (41)
Role of oxygen radicals in experimental allergic uveitis. (1987) (40)
Effects of Cortisol and Aminophylline upon Survival, Pulmonary Mechanics, and Secreted Phosphatidyl Choline of Prematurely Delivered Rabbits (1978) (40)
Effects of vitamin E deficiency and nitrogen dioxide exposure on lung lipid peroxidation: use of lipid epoxides and malonaldehyde as measures of peroxidation. (1982) (40)
Inhibition of arachidonic acid release by nordihydroguaiaretic acid and its antioxidant action in rat alveolar macrophages and Chinese hamster lung fibroblasts. (1990) (40)
Free radical mechanisms in chemical pathogenesis. Summary of the symposium presented at the 1988 annual meeting of the Society of Toxicology. (1988) (39)
Wine Polyphenols and Optimal Nutrition (2002) (39)
Peroxidation and phospholipase A2 hydrolytic susceptibility of liposomes consisting of mixed species of phosphatidylcholine and phosphatidylethanolamine. (1992) (39)
Phospholipase A2 Stimulation by Methyl Mercury in Neuron Culture (1994) (38)
Hematin- and peroxide-catalyzed peroxidation of phospholipid liposomes. (1991) (38)
Heme and lipid peroxides in hemoglobin-modified low-density lipoprotein mediate cell survival and adaptation to oxidative stress. (2003) (36)
[19] Uric acid: Functions and determination (1984) (36)
Effect of linoleic acid hydroperoxide on endothelial cell calcium homeostasis and phospholipid hydrolysis. (1995) (35)
Ascorbic acid enhances 17 beta-estradiol-mediated inhibition of oxidized low density lipoprotein formation. (2000) (35)
Phospholipid synthesis in fetal lung organotypic cultures and isolated type II pneumocytes. (1981) (34)
Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension. (2002) (34)
Inhibition of LDL Oxidation and Oxidized LDL-induced Cytotoxicity by Dihydropyridine Calcium Antagonists (2000) (34)
Epoxides as products of lipid autoxidation in rat lungs (1979) (34)
Antioxidant effect of simvastatin is not enhanced by its association with alpha-tocopherol in hypercholesterolemic patients. (2004) (34)
Oxidative Modification of Low-Density Lipoprotein (LDL) in HD Patients: Role in Electronegative LDL Formation (2000) (34)
Role of beta2-glycoprotein I, LDL-, and antioxidant levels in hypercholesterolemic elderly subjects. (2004) (33)
Physical effects of biologically formed cholesterol oxidation products on lipid membranes investigated with fluorescence depolarization spectroscopy and electron spin resonance. (1996) (32)
Role of annexin II in estrogen-induced macrophage matrix metalloproteinase-9 activity: the modulating effect of statins. (2006) (32)
Lipid epoxide hydrolase in rat lung preparations. (1980) (32)
Oxidative stress during ex vivo hemodialysis of blood is decreased by a novel hemolipodialysis procedure utilizing antioxidants. (2002) (31)
Oxidative stress increases eukaryotic initiation factor 4E phosphorylation in vascular cells. (2003) (31)
4-Hydroxynonenal: a specific indicator for canine neuronal-retinal ceroidosis. (1988) (31)
Metabolism of epoxidized phosphatidylcholine by phospholipase A2 and epoxide hydrolase (1981) (29)
Measurement of uric acid, ascorbic acid, and related metabolites in biological fluids. (1984) (29)
Lipid peroxidation and modification of lipid composition in an endothelial cell model of ischemia and reperfusion. (1997) (29)
Modulation of lens-induced uveitis by superoxide dismutase. (1986) (29)
Mutagenic characterization of cholesterol epoxides in Chinese hamster V79 cells. (1988) (28)
Retinal lipid peroxidation in experimental uveitis. (1987) (28)
Lipid peroxidation in experimental uveitis: sequential studies. (1992) (27)
Induction by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of lipid peroxidation in vivo in vitamin E deficient mice. (1990) (26)
Effect of iron chelation on severity of ocular inflammation in an animal model. (1986) (25)
Treatment of experimental granulomatous uveitis by lipoxygenase and cyclo-oxygenase inhibitors. (1987) (25)
DPH lifetime distributions in vesicles containing phospholipid hydroperoxides. (1989) (24)
Adenylate Cyclase Activity in Immature Rabbit Lung (1974) (24)
Impact of oxidized lipids and antioxidants, such as vitamin E and lazaroids, on the structure and dynamics of unsaturated membranes (1992) (22)
Induction of cytotoxicity and mutagenesis is facilitated by fatty acid hydroperoxidase activity in Chinese hamster lung fibroblasts (V79 cells). (1989) (22)
Enhancement of Fetal Lung Surfactant Production by Aminophylline (1978) (22)
Hypochlorite induces the formation of LDL−, a potentially atherogenic low density lipoprotein subspecies (2001) (19)
Epoxide hydrolases in the catabolism of sterols and isoprenoids. (1985) (19)
Long-term effect of estrogen replacement on plasma nitric oxide levels: results from the estrogen in the prevention of atherosclerosis trial (EPAT). (2005) (19)
Treatment of experimental Pseudomonas keratitis with cyclo-oxygenase and lipoxygenase inhibitors. (1991) (18)
Effect of vitamin E on arachidonic acid peroxidation and its binding to Chinese hamster V79 cell DNA. (1991) (18)
Antiphlogistic effect of catalase on experimental phacoanaphylactic endophthalmitis. (1986) (18)
Oxidative stress resulting from hemolysis and formation of catalytically active hemoglobin: protective strategies. (1999) (17)
Probucol suppresses oxidant stress in hypertensive arteries. Immunohistochemical evidence. (1996) (17)
Effect of cholesterol epoxides on the inhibition of intercellular communication and on mutation induction in Chinese hamster V79 cells. (1988) (17)
Impact of water‐dispersible beadlets as a vehicle for the delivery of carotenoids to cultured cells (2002) (16)
Anti-inflammatory effect of glutathione peroxidase on experimental lens-induced uveitis. (1988) (16)
Probucol Reduces Oxysterol Formation in Hypertensive Rabbits (2000) (16)
Lipid damage and repair (1990) (16)
Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress. (2005) (16)
Mechanisms of ascorbic acid-induced inhibition of chemical transformation in C3H/10T1/2 cells. (1991) (16)
Suppression of S antigen-induced uveitis by vitamin E supplementation. (1991) (15)
Hydrogen peroxide localization in ocular tissue: an electron microscopic cytochemical study. (1988) (15)
Oxysterols Are Increased in Plasma of End-Stage Renal Disease Patients (2006) (15)
Modulation of experimental phacoanaphylactic endophthalmitis with the antioxidants sodium benzoate, and 2,3-dihydroxybenzoic acid. (1987) (15)
Anti-inflammatory effects of vitamin E on experimental lens-induced uveitis (2004) (13)
Immunohistochemical localization of peroxidative enzymes in ocular tissue. (1990) (12)
Harmonization of methods for analysis of cholesterol oxides in foods--the first portion of a long road toward standardization: interlaboratory study. (2004) (12)
Generation of chemiluminescence in experimental autoimmune uveitis. (1991) (11)
The genotoxic effects of arachidonic acid in V79 cells are mediated by peroxidation products. (1993) (11)
Treatment of experimental lens-induced uveitis by dimethyl thiourea. (1988) (10)
Influence of vitamin E and nitrogen dioxide on lipid peroxidation in rat lung and liver microsomes (1982) (10)
Recent Advances in Nutritional Sciences Nutritional, Dietary and Postprandial Oxidative Stress 1,2 (2005) (9)
Modulation of lens-induced uveitis by dimethyl sulfoxide. (1986) (8)
Collisional spectroscopy approaches in the characterization of 7-α- and 7-β-hydroxycholesterol (1991) (8)
Uric acid: functions and determination. (1984) (8)
Antioxidant Vitamin Supplementation and Cardiovascular Disease (2005) (7)
Ultrastructural localization of hydrogen peroxide in experimental autoimmune uveitis. (1992) (6)
Lipid peroxiodation in membranes and lipoproteins: similarities and differences (2000) (6)
Treatment of S antigen uveoretinitis with lipoxygenase and cyclo-oxygenase inhibitors. (1991) (6)
Abstracts of the 28th Meeting Eye Research (1988) (6)
LIPID PEROXIDATION IN MODEL AND NATURAL MEMBRANES (1979) (5)
Cholesterol photodynamic oxidation by ultraviolet irradiation and cholesterol ozonization by ozone exposure. (2000) (5)
CONTEMPORARY ISSUES IN TOXICOLOGY Free Radical Mechanisms in Chemical Pathogenesis (2003) (5)
Antioxidant Vitamins and Atherosclerosis (2001) (4)
LDL modification during hemodialysis. Markers for oxidative stress. (2002) (4)
1224 ENHANCEMENT OF FETAL LUNG SURFACTANT PRODUCTION BY AMINOPHYLLINE (1978) (4)
Peroxidation of Lipids in Model Systems and in Biomembranes (1980) (3)
Phospholipase A2 Activation: An Early Manifestation of Oxidative Stress (1997) (3)
LDL Modification during Hemodialysis (2002) (3)
Cholesterol oxidation products and fibrogenesis (2001) (3)
Retinal lipid peroxidation in intraocular inflammation (1990) (3)
Impact of Oxidized Lipids and Antioxidants, such as Vitamin E and Lazaroids, on the Structure and Dynamics of Unsaturated Membranes. (1992) (3)
Incorporation of arachidonic, dihomogamma linolenic and eicosapentaenoic acids into cultured V79 cells (1989) (3)
The effect of oxygen exposure on erythrocyte phospholipid composition. (1981) (3)
Biochemical and cytotoxic in vivo circulating oxidized (LDL-) characteristics of an low density lipoprotein (1994) (2)
Binding of arachidonic acid peroxidation products to Chinese hamster V79 cell DNA: Effects of vitamin e and selenium (1990) (2)
Direct Detection of Reactive Nitrogen Species in Experimental Autoimmune Uveitis (2007) (2)
Effect of Ascorbic and Dehydroascorbic Acids on Lipid Composition of C3H/10T1/2 Cells a (1987) (2)
Plasma cholesterol oxide levels in normocholesterolemic and cholesterol-fed New Zealand white rabbits (1990) (2)
STRUCTURAL AND DYNAMIC EFFECTS OF OXIDIZED LIPIDS IN UNSATURATED LIPID MEMBRANES IN RELATION TO VITAMIN E ACTIVITY (1991) (2)
The stabilization of ascorbic acid by uric acid. (1986) (2)
Abstracts of the 26th Meeting forof the Assciation Eye Research (1986) (1)
Effect of Platelet Activating Factor-Acetyihydrolase on the Formation and Action of Minimally Oxidized Low Density Lipoprotein (2013) (1)
EFFECTS OF MATERNALLY ADMINISTERED CORTISONE ON CYCLIC AMP AND PHOSPHOLIPIDS IN FETAL RABBIT LUNGS (1974) (1)
Chemotactic factors of lipid origin in intraocular inflammation (1990) (1)
Collisional spectroscopy approaches in the characterization of 7-alpha- and 7-beta-hydroxycholesterol. (1991) (1)
Cytotoxic Mechansims for Cholesterol Oxidation Products in Fibroblasts and Endothelial Cells (1988) (1)
Structural and dynamic effects of oxidized lipids in unsaturated lipid membranes (1990) (1)
Slow-motion ESR study of oxidized oriented phospholipid multibilayers (1990) (1)
NATIVE LDL OXIDATION IN RESPONSE TO PULSATILE FLOW: IMPLICATION FOR NADPH OXIDASE EXPRESSION (2004) (0)
Reports Superoxide Dismutase in Ocular Structures (2005) (0)
DPH FLUORESCENCE LIFETIME DISTRIBUTIONS IN OXIDIZED CARDIOLIPIN VESICLES (1992) (0)
Subject Index Vol. 28, 2005 (2006) (0)
Probucol suppresses oxidative stress in hypertensive arteries of NZW rabbits (1994) (0)
Contents Vol. 28, 2005 (2006) (0)
Managing Coronary Heart Disease in Chronic Uremia (2006) (0)
17BETA-ESTRADIOL ATTENUATES OSCILLATORY FLOW-INDUCED LDL OXIDATION (2004) (0)
OXPAPC DOWN-REGULATE ENDOTHELIAL TIGHT JUNCTION PROTEIN EXPRESSION: IMPLICATION FOR LOCALIZED PERMEABILITY (2004) (0)
Oxidative Damage to Circulating LDL (1993) (0)
Young investigator award (1991) (0)
Pro-fibrogenic and pro-apoptotic effects of oxisterols, oxidised derivatives of cholesterol. (2002) (0)
G-protein modulation of in situ phospholipase A2 activity in neuronal culture (1992) (0)
Inhibition of lecithin: Cholesterol acyltransferase by cholesterol oxides (2000) (0)
THE STABILIZATION OP ASCORBIC ACID BY URIC ACID: 87 (1985) (0)
Lipid peroxidation induced CA2+ signalling of phospholipase A2 activity (1993) (0)
Histochemical analysis of experimental granulomatous uveitis. (1991) (0)
1722 PHOSPHOLIPID PRODUCTION IN FETAL LUNG CELL CULTURE PREPARATIONS (1981) (0)

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