Alex Sigal
Researcher
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Computer Science
Alex Sigal's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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(Suggest an Edit or Addition)According to Wikipedia, Alex Sigal is a South Africa–based virologist at the Africa Health Research Institute in Durban, South Africa, Max Planck Institute for Infection Biology in Berlin, and University of KwaZulu-Natal in Durban. His work concentrates on evolution and persistence of the SARS-CoV-2 virus. His laboratory was the first to isolate the live B.1.351 variant of SARS-CoV-2 first detected in South Africa. Sigal’s laboratory was also the first to report results on the ability of the Omicron variant to escape antibody neutralization in individuals who had two doses of the Pfizer BNT162b2 vaccine as well as from previous infections, with results also suggesting that vaccination combined with a booster or previous infection can offer protection from symptomatic infection with Omicron.
Alex Sigal's Published Works
Published Works
- Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa (2020) (1066)
- Dynamics of the p53-Mdm2 feedback loop in individual cells (2004) (1010)
- Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant (2021) (937)
- Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. (2000) (744)
- Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization (2021) (733)
- Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity (2021) (731)
- Detection of a SARS-CoV-2 variant of concern in South Africa (2021) (724)
- Oscillations and variability in the p53 system (2006) (641)
- Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein. (2021) (606)
- Dynamic Proteomics of Individual Cancer Cells in Response to a Drug (2008) (586)
- Variability and memory of protein levels in human cells (2006) (575)
- Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy (2011) (476)
- Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma (2021) (472)
- Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity (2021) (444)
- Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity (2022) (382)
- Collective and single cell behavior in epithelial contact inhibition (2011) (368)
- SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection (2021) (298)
- Sixteen novel lineages of SARS-CoV-2 in South Africa (2021) (286)
- T cell responses to SARS-CoV-2 spike cross-recognize Omicron (2022) (284)
- Dynamics and variability of ERK2 response to EGF in individual living cells. (2009) (237)
- Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53 (2001) (157)
- The LFA-1 Integrin Supports Rolling Adhesions on ICAM-1 Under Physiological Shear Flow in a Permissive Cellular Environment1 (2000) (154)
- Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins (2006) (144)
- Escape of SARS-CoV-2 501Y.V2 variants from neutralization by convalescent plasma (2021) (126)
- Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity (2021) (102)
- Safety and efficacy of the ChAdOx1 nCoV-19 (AZD1222) Covid-19 vaccine against the B.1.351 variant in South Africa (2021) (96)
- Integrity of the N‐terminal transcription domain of p53 is required for mutant p53 interference with drug‐induced apoptosis (2001) (93)
- Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern (2021) (93)
- SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape (2022) (92)
- Milder disease with Omicron: is it the virus or the pre-existing immunity? (2022) (88)
- Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells (2017) (86)
- Estimating disease severity of Omicron and Delta SARS-CoV-2 infections (2022) (79)
- Persistent SARS-CoV-2 infection and intra-host evolution in association with advanced HIV infection (2021) (77)
- Generation of a fluorescently labeled endogenous protein library in living human cells (2007) (70)
- Pegylated nanoliposomes remote-loaded with the antioxidant tempamine ameliorate experimental autoimmune encephalomyelitis (2009) (69)
- Glucocorticoids in nano-liposomes administered intravenously and subcutaneously to adjuvant arthritis rats are superior to the free drugs in suppressing arthritis and inflammatory cytokines. (2012) (65)
- Fabrication Principles and Their Contribution to the Superior In Vivo Therapeutic Efficacy of Nano-Liposomes Remote Loaded with Glucocorticoids (2011) (65)
- Protein Dynamics in Individual Human Cells: Experiment and Theory (2009) (64)
- Circulating SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity (2021) (63)
- Omicron sub-lineages BA.4/BA.5 escape BA.1 infection elicited neutralizing immunity (2022) (61)
- SARS-CoV-2 Omicron spike mediated immune escape and tropism shift (2022) (53)
- Omicron infection enhances Delta antibody immunity in vaccinated persons (2022) (49)
- SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron (2021) (48)
- Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection (2022) (46)
- HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens (2021) (45)
- As good as it gets? The problem of HIV persistence despite antiretroviral drugs. (2012) (44)
- HIV Cell-to-Cell Spread Results in Earlier Onset of Viral Gene Expression by Multiple Infections per Cell (2016) (39)
- Analysis: A meta-analysis of Early Results to predict Vaccine efficacy against Omicron (2021) (38)
- Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains (2021) (36)
- The continuous evolution of SARS-CoV-2 in South Africa: a new lineage with rapid accumulation of mutations of concern and global detection (2021) (35)
- Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function (2022) (32)
- Author Correction: Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection (2022) (31)
- Similar antibody responses against SARS-CoV-2 in HIV uninfected and infected individuals on antiretroviral therapy during the first South African infection wave. (2021) (31)
- Omicron infection of vaccinated individuals enhances neutralizing immunity against the Delta variant (2021) (30)
- Dynamic Proteomics: a database for dynamics and localizations of endogenous fluorescently-tagged proteins in living human cells (2009) (29)
- HIV infection alters SARS-CoV-2 responsive immune parameters but not clinical outcomes in COVID-19 disease (2020) (26)
- Emergence and phenotypic characterization of C.1.2, a globally detected lineage that rapidly accumulated mutations of concern (2021) (26)
- Selection Analysis Identifies Clusters of Unusual Mutational Changes in Omicron Lineage BA.1 That Likely Impact Spike Function (2022) (25)
- A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy (2021) (24)
- Using PEGylated nano-liposomes to target tissue invaded by a foreign body (2008) (24)
- Major new lineages of SARS-CoV-2 emerge and spread in South Africa during lockdown. (2020) (22)
- Viral Apoptosis Evasion via the MAPK Pathway by Use of a Host Long Noncoding RNA (2017) (21)
- Dynamic Proteomics of Human Protein Level and Localization across the Cell Cycle (2012) (20)
- HIV status alters disease severity and immune cell responses in beta variant SARS-CoV-2 infection wave. (2021) (20)
- Two doses of SARS-CoV-2 vaccination induce more robust immune responses to emerging SARS-CoV-2 variants of concern than does natural infection. (2021) (19)
- The C-terminus of mutant p53 is necessary for its ability to interfere with growth arrest or apoptosis (2001) (19)
- Noise Genetics: Inferring Protein Function by Correlating Phenotype with Protein Levels and Localization in Individual Human Cells (2014) (19)
- Metformin as Host-Directed Therapy for TB Treatment: Scoping Review (2020) (17)
- Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage (2022) (16)
- Immunogenicity of SARS-CoV-2 infection and Ad26.CoV2.S vaccination in people living with HIV. (2021) (15)
- T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy (2021) (15)
- A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy (2022) (13)
- SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization (2021) (13)
- Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology (2021) (11)
- Immunogenicity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Ad26.CoV2.S Vaccination in People Living With Human Immunodeficiency Virus (HIV) (2021) (11)
- Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death (2017) (10)
- Dendritic cells efficiently transmit HIV to T Cells in a tenofovir and raltegravir insensitive manner (2018) (10)
- Diminished HIV Infection of Target CD4+ T Cells in a Toll-Like Receptor 4 Stimulated in vitro Model (2019) (9)
- Divergence of delta and beta variants and SARS-CoV-2 evolved in prolonged infection into distinct serological phenotypes (2021) (8)
- Correction: Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells (2017) (7)
- Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response (2021) (7)
- Short communication: Lower baseline CD4 count is associated with a greater propensity toward virological failure in a cohort of South African HIV patients. (2014) (6)
- Interference with HIV infection of the first cell is essential for viral clearance at sub-optimal levels of drug inhibition (2020) (6)
- SARS-CoV-2 Omicron variant emerged under immune selection (2022) (6)
- Naturally-acquired immunity in Syrian Golden Hamsters provides protection from re-exposure to emerging heterosubtypic SARS-CoV-2 variants B.1.1.7 and B.1.351 (2021) (6)
- Author Correction: T cell responses to SARS-CoV-2 spike cross-recognize Omicron (2022) (5)
- Similar Antibody Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 in Individuals Living Without and With Human Immunodeficiency Virus on Antiretroviral Therapy During the First South African Infection Wave (2021) (4)
- The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes (2022) (4)
- The Oncogenic Activity of p53 Mutants (2005) (4)
- The CNS in the face of ART contains T cell origin HIV which can lead to drug resistance (2019) (3)
- Author Correction: T cell responses to SARS-CoV-2 spike cross-recognize Omicron (2022) (3)
- The importance of time post-vaccination in determining the decrease in vaccine efficacy against SARS-CoV-2 variants of concern (2021) (3)
- Betamethasone induces potent immunosuppression and reduces HIV infection in a PBMC in vitro model (2020) (3)
- Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition (2022) (3)
- The Universe as a Graviton Condensate: The “Dark-Bright Conjecture” (2017) (2)
- Development of highly potent neutralising nanobodies against multiple SARS-CoV-2 variants including the variant of concern B.1.351 (2021) (2)
- Beta infection combined with Pfizer BNT162b2 vaccination leads to broadened neutralizing immunity against Omicron (2022) (2)
- HIV viremia is associated with compromised SARS-CoV-2 Beta variant neutralization. (2022) (2)
- FINANCING TRANSIT-ORIENTED DEVELOPMENT. IN: THE NEW TRANSIT TOWN: BEST PRACTICES IN TRANSIT-ORIENTED DEVELOPMENT (2004) (1)
- HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway (2022) (1)
- A high‐resolution 3D atlas of the spectrum of tuberculous and COVID‐19 lung lesions (2022) (1)
- Systems biology meets chromatin function: a report on the Fourth Elmau Conference on Nuclear Organization (2007) (1)
- Complementation can maintain a quasispecies of drug sensitive and resistant HIV (2020) (1)
- Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity (2022) (1)
- HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells (2021) (1)
- Omicron infection enhances Delta antibody immunity in vaccinated persons (2022) (0)
- Dynamics of SARS-CoV-2 VOC neutralization and novel mAb reveal protection against Omicron (2022) (0)
- SARS-CoV-2 evolves increased infection elicited cell death and fusion in an immunosuppressed individual (2022) (0)
- NPGRJ_NMETH_892 525..531 (2006) (0)
- Author response: HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave (2021) (0)
- Association Between Human Immunodeficiency Virus Viremia and Compromised Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Beta Variant (2022) (0)
- The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes (2022) (0)
- SARS-CoV-2 viral replication persists in the human lung for several weeks after onset of symptomatic severe COVID-19 and is associated with attenuated pulmonary immunity and variant-specific clinical sequalae (2023) (0)
- Interference with HIV infection of the first cell is essential for viral clearance in a pre-exposure prophylaxis model (2018) (0)
- SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants (2023) (0)
- Review 2: "Infectivity and immune escape of the new SARS-CoV-2 variant of interest Lambda" (2021) (0)
- HIV cell-to-cell spread slows evolution of drug resistance (2020) (0)
- Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron (2023) (0)
- Boosting in the age of Omicron. (2023) (0)
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