Alex Toker | Academic Influence

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Alex Toker

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Philosophy

Alex Toker's Degrees

Bachelors Biology Stanford University

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Why Is Alex Toker Influential?

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According to Wikipedia, Alex Toker is currently a professor at the Department of Pathology at Beth Israel Deaconess Medical Center, Harvard Medical School and Chief of the Division of Signal Transduction and Associate Director of the Cancer Research Institute in the Cancer Center. His research focus on understanding mechanism of cancer including tumor cell survival, invasion and metastasis. He is currently editor-in-chief of the Journal of Biological Chemistry.

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Alex Toker's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

AKT/PKB Signaling: Navigating the Network (2017) (2036)
Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate (1997) (1573)
Signalling through the lipid products of phosphoinositide-3-OH kinase (1997) (1401)
Sequence analysis of mutations and translocations across breast cancer subtypes (2012) (1133)
Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets (1995) (683)
Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion (1997) (626)
Regulation of protein kinase C ζ by PI 3-kinase and PDK-1 (1998) (621)
Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes* (1997) (582)
Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site* (2000) (571)
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. (1994) (516)
Cellular Signaling Pivoting around PDK-1 (2000) (450)
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. (2005) (430)
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. (1999) (425)
The role of NFAT transcription factors in integrin-mediated carcinoma invasion (2002) (417)
Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) (1998) (397)
Protein kinases as mediators of phosphoinositide 3-kinase signaling. (2000) (353)
Signaling through protein kinase C. (1998) (341)
A rapid method for determining protein kinase phosphorylation specificity (2004) (339)
NFAT proteins: emerging roles in cancer progression (2009) (332)
PI3K signaling in cancer: beyond AKT. (2017) (317)
Protein kinase D mediates a stress‐induced NF‐κB activation and survival pathway (2003) (314)
Akt signaling and cancer: surviving but not moving on. (2006) (311)
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus (2014) (301)
Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex (2005) (289)
The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate. (1998) (275)
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. (2015) (275)
Protein Kinase C–Dependent Mobilization of the α6β4 Integrin from Hemidesmosomes and Its Association with Actin-Rich Cell Protrusions Drive the Chemotactic Migration of Carcinoma Cells (1999) (248)
Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. (2009) (245)
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction (2009) (236)
Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. (1997) (236)
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. (2011) (230)
Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation (1995) (223)
Protein Kinase D Mediates Mitochondrion-to-Nucleus Signaling and Detoxification from Mitochondrial Reactive Oxygen Species (2005) (220)
Phosphoinositides and signal transduction (2002) (219)
Protein kinase C inhibitor proteins. Purification from sheep brain and sequence similarity to lipocortins and 14-3-3 protein. (1990) (215)
Protein Kinase Cδ Selectively Regulates Protein Kinase D-Dependent Activation of NF-κB in Oxidative Stress Signaling (2004) (213)
p70 S6 Kinase Is Regulated by Protein Kinase Cζ and Participates in a Phosphoinositide 3-Kinase-Regulated Signalling Complex (1999) (203)
Insulin Activates Protein Kinases C-ζ and C-λ by an Autophosphorylation-dependent Mechanism and Stimulates Their Translocation to GLUT4 Vesicles and Other Membrane Fractions in Rat Adipocytes* (1999) (200)
Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. (1997) (196)
A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions. (2005) (187)
Acetylation-Dependent Regulation of Skp2 Function (2012) (183)
Glutathione biosynthesis is a metabolic vulnerability in PI3K/Akt-driven breast cancer (2016) (177)
Signaling specificity in the Akt pathway in biology and disease. (2014) (172)
Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. (2005) (170)
The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration. (2010) (167)
A Phosphorylation State-specific Antibody Recognizes Hsp27, a Novel Substrate of Protein Kinase D* (2005) (166)
Regulation of novel protein kinase C ε by phosphorylation (2002) (162)
Regulation of novel protein kinase C ε by phosphorylation (2002) (162)
Akt/PKB Signaling in Cancer: A Function in Cell Motility and Invasion (2006) (157)
NFAT Induces Breast Cancer Cell Invasion by Promoting the Induction of Cyclooxygenase-2* (2006) (153)
FOXO3a Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases (2009) (152)
PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1 (1999) (150)
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner (2016) (144)
The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C* (1997) (141)
D3 Phosphoinositides and Outside-in integrin Signaling by Glycoprotein IIb-IIIa Mediate Platelet Actin Assembly and Filopodial Extension Induced by Phorbol 12-Myristate 13-Acetate* (1996) (131)
SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. (2014) (127)
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. (2004) (127)
Multiple isoforms of a protein kinase C inhibitor (KCIP-1/14-3-3) from sheep brain. Amino acid sequence of phosphorylated forms. (1992) (125)
Targeting Akt3 signaling in triple-negative breast cancer. (2014) (125)
3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. (2009) (124)
Tyrosine Phosphorylation of Protein Kinase D in the Pleckstrin Homology Domain Leads to Activation* (2003) (120)
3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling. (2002) (116)
Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer. (2017) (115)
Regulation of Oxysterol-binding Protein Golgi Localization through Protein Kinase D–mediated Phosphorylation (2010) (114)
The Carboxyl Terminus of Protein Kinase C Provides a Switch to Regulate Its Interaction with the Phosphoinositide-dependent Kinase, PDK-1* (2001) (111)
Activation Loop Phosphorylation Controls Protein Kinase D-Dependent Activation of Nuclear Factor κB (2004) (106)
Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes. (1999) (103)
Calcium-dependent Regulation of Protein Kinase D Revealed by a Genetically Encoded Kinase Activity Reporter* (2007) (103)
The phosphoinositide 3-kinase pathway and therapy resistance in cancer (2015) (101)
Phosphoinositide 3-Kinase Binds Constitutively to α/β-Tubulin and Binds to γ-Tubulin in Response to Insulin (*) (1995) (101)
NFAT promotes carcinoma invasive migration through glypican-6 (2011) (99)
Association of Protein Kinase Cμ with Type II Phosphatidylinositol 4-Kinase and Type I Phosphatidylinositol-4-phosphate 5-Kinase* (1998) (96)
Kinase and neurotransmitters (1990) (94)
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. (2010) (92)
Carbachol, Substance P, and Phorbol Ester Promote the Tyrosine Phosphorylation of Protein Kinase Cδ in Salivary Gland Epithelial Cells (*) (1995) (91)
Aspirin Suppresses Growth in PI3K-Mutant Breast Cancer by Activating AMPK and Inhibiting mTORC1 Signaling. (2017) (87)
Regulation of novel protein kinase C epsilon by phosphorylation. (2002) (86)
Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. (2016) (86)
Nonessential amino acid metabolism in breast cancer. (2016) (85)
Mechanisms of Cold-induced Platelet Actin Assembly* (2001) (82)
Akt methylation by SETDB1 promotes Akt kinase activity and oncogenic functions (2018) (80)
The Lipid Products of Phosphoinositide 3-Kinase Contribute to Regulation of Cholangiocyte ATP and Chloride Transport* (1999) (79)
Phosphatidylinositol 3‐kinase is recruited to a specific site in the activated IL‐1 receptor I (1998) (77)
Akt isoform-specific signaling in breast cancer (2011) (76)
PTEN-deficient tumors depend on AKT2 for maintenance and survival. (2014) (74)
Achieving specificity in Akt signaling in cancer. (2012) (72)
Akt/Protein Kinase B and Glycogen Synthase Kinase-3β Signaling Pathway Regulates Cell Migration through the NFAT1 Transcription Factor (2009) (72)
Phosphorylation of the Platelet p47 Phosphoprotein Is Mediated by the Lipid Products of Phosphoinositide 3-Kinase (*) (1995) (70)
Lacrimal gland PKC isoforms are differentially involved in agonist-induced protein secretion. (1997) (70)
Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling (2019) (69)
Signalling specificity in the Akt pathway in breast cancer. (2014) (68)
Functional dichotomy of A20 in apoptotic and necrotic cell death. (2005) (64)
Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT (2017) (55)
Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration. (2010) (53)
Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer. (2017) (52)
Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association (2008) (51)
Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. (1995) (50)
NF-κB Signaling: An ALternate Pathway for Oxidate Stress Responses (2003) (47)
PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5. (2012) (47)
The Adherens Junction Protein Afadin Is an AKT Substrate that Regulates Breast Cancer Cell Migration (2013) (44)
LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer (2016) (43)
Cross-talk between the CK2 and AKT signaling pathways in cancer. (2017) (43)
RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. (2013) (42)
The biology and biochemistry of diacylglycerol signalling (2005) (38)
Antagonists of Calcium Fluxes and Calmodulin Block Activation of the p21-Activated Protein Kinases in Neutrophils1 (2001) (38)
PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition (2000) (37)
The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis (2017) (37)
MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy. (2015) (36)
Pentraxin-3 is a PI3K signaling target that promotes stem cell–like traits in basal-like breast cancers (2017) (35)
Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors (2018) (35)
Akt2 regulates expression of the actin‐bundling protein palladin (2010) (32)
NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer (2015) (32)
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy (2020) (30)
mTOR and Akt signaling in cancer: SGK cycles in. (2008) (28)
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer. (2020) (25)
Stimulation of an Insulin Receptor Activates and Down‐Regulates the Ca2+‐Independent Protein Kinase C, Apl II, Through a Wortmannin‐Sensitive Signaling Pathway in Aplysia (1996) (25)
The role of specific isoforms of 14-3-3 protein in regulating protein kinase activity in the brain. (1992) (23)
Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis (2016) (23)
The biology and biochemistry of diacylglycerol signalling. Meeting on molecular advances in diacylglycerol signalling. (2005) (21)
Effect of Overexpression of Protein Kinase Cα on Rat Lacrimal Gland Protein Secretion (2002) (19)
Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion. (2004) (19)
Phosphoinositide 3-kinases-a historical perspective. (2012) (18)
Placental tissue cyclo‐oxygenase 1 and 2 in pre‐eclamptic and normal pregnancy (2006) (17)
PI3K drives the de novo synthesis of coenzyme A from vitamin B5 (2022) (15)
TTC3 ubiquitination terminates Akt-ivation. (2009) (15)
Akt-ing up on SRPK1: oncogene or tumor suppressor? (2014) (15)
Akt signaling: a damaging interaction makes good. (2008) (15)
Inhibition of phosphoinositide 3-kinase impairs pre-commitment cell cycle traverse and prevents differentiation in erythroleukaemia cells (2000) (15)
Phosphorylation of the Activation Loop of γ p21-Activated Kinase (γ-Pak) and Related Kinases (MSTs) in Normal and Stressed Neutrophils1 (2001) (14)
PDK-1 and protein kinase C phosphorylation. (2003) (13)
PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K? (2015) (12)
Platelet protein phosphorylation and protein kinase C activation by phorbol esters with different biological activity and a novel synergistic response with Ca2+ ionophore. (1990) (11)
FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance (2021) (11)
Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia (2020) (9)
Meeting on Molecular Advances in Diacylglycerol Signalling (2005) (7)
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype (2021) (7)
Using phospho-motif antibodies to determine kinase substrates. (2013) (6)
Oncogenic AKT 1 ( E 17 K ) mutation induces mammary hyperplasia but prevents HER 2-driven tumorigenesis (2016) (4)
Lactate Lights up PI3K Inhibitor Resistance in Breast Cancer. (2020) (4)
Faculty Opinions recommendation of Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt. (2018) (4)
PI 3-Kinase Signaling: AKTing up inside the Cell. (2018) (4)
WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models. (2021) (4)
Faculty Opinions recommendation of mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. (2006) (4)
Genetic manipulation of protein kinase C in vivo. (2003) (4)
-Dependent Activation of the mTORC2 Kinase Complex (2015) (3)
Double trouble for cancer gene (2019) (3)
Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion. (2002) (3)
On board. (2003) (3)
Phosphorylation of the activation loop of gamma p21-activated kinase (gamma-Pak) and related kinases (MSTs) in normal and stressed neutrophils. (2001) (2)
PDK 1 potentiates upstream lesions on the PI 3 K pathway in breast carcinoma (2009) (2)
Phosphatidylinositol Bisphosphate and Trisphosphate (2013) (2)
Faculty Opinions recommendation of MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. (2009) (2)
Identifying Protein Kinase C Substrates (2003) (2)
Faculty Opinions recommendation of Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth. (2018) (1)
The lipid products of phosphatidylinositol 3-kinase mediate chemotaxis via protein kinase C (1995) (1)
The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia (2021) (1)
Abstract B195: MAGI3-Akt3, a novel fusion protein in the PI3K pathway in cancer. (2013) (1)
Abstract 4090: Akt2-specific signaling in prostate cancer maintenance. (2013) (1)
THE LIPID PRODUCTS OF PHOSPHOINOSITIDE 3-KINASE REGULATE CHOLANGIOCYTE ATP AND CHLORIDE TRANSPORT (1999) (1)
Inhibiting the uninhibited: on the specificity of protein kinase inhibitors (2007) (1)
JAK–STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States (2022) (1)
eNOS gene polymorphisms and transitional cell cancer of the bladder (2020) (1)
Faculty Opinions recommendation of Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis. (2011) (1)
Abstract A42: Increased Akt3 expression as a resistance mechanism to targeted therapy (2015) (1)
Abstract 4421: PTEN-deficient tumors depend on Akt2 for maintenance (2014) (1)
Cellular Signaling: Pivoting Minireview around PDK-1 (2000) (1)
Identifying protein kinase C substrates: an introduction. (2003) (1)
through Tumor-Stromal Interactions A Secreted Form of ADAM 9 Promotes Carcinoma Invasion (2005) (1)
elegans Caenorhabditis PI 3 kinase signals that regulate diapause in A PDK 1 homolog is necessary and sufficient to transduce AGE-1 (1999) (1)
Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation (2022) (0)
Faculty Opinions recommendation of Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers. (2020) (0)
318 A secreted form of ADAM9 by liver myofibroblasts promotes tumor invasion through stromal-tumor interactions (2004) (0)
Tumor and Stem Cell Biology Targeting Akt 3 Signaling in Triple-Negative Breast Cancer (2014) (0)
Faculty Opinions recommendation of An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. (2005) (0)
Faculty of 1000 evaluation for A metabolic function of FGFR3-TACC3 gene fusions in cancer. (2018) (0)
Faculty Opinions recommendation of The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. (2008) (0)
Abstract IA06: PI 3-kinase and Akt at the interface of signaling and metabolism (2015) (0)
Faculty Opinions recommendation of Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. (2004) (0)
Abstract 3838: Akt isoform-specific signaling in breast cancer cell invasive migration (2010) (0)
p 21-Activated Protein Kinases in Neutrophils Calmodulin Block Activation of the Antagonists of Calcium Fluxes and Coffer (2001) (0)
EFFECT OF POLYTETRAFLUOROETHYLENE GRAFT TO DOSE DISTRIBUTION FOR PHOTON AND ELECTRON BEAMS (2008) (0)
Abstract P4-01-04: FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces therapeutic resistance in triple negative breast cancer (2022) (0)
Faculty Opinions recommendation of Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis. (2019) (0)
Faculty Opinions recommendation of RalGDS is required for tumor formation in a model of skin carcinogenesis. (2005) (0)
Faculty Opinions recommendation of Dimeric PKD regulates membrane fission to form transport carriers at the TGN. (2008) (0)
Abstract 549: MAGI3-Akt3, a novel fusion protein in the PI 3-K pathway in cancer. (2013) (0)
Faculty Opinions recommendation of Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. (2013) (0)
1196 Akt Isoform-specific Signaling in Prostate Cancer (2012) (0)
Abstract 547: Inhibition of PI 3-K isoforms lead to reactivation of Akt signaling in a subset of breast cancer cell lines. (2013) (0)
Abstract B8: The two isoforms of ADAM9 have opposing roles in breast cancer cell migration (2009) (0)
Regulation of the P21-activated protein kinases (PAKS) in neutrophils by phosphoinositides and sphingolipids (1999) (0)
The PI3K-AKT signal transduction: update and future direction (2016) (0)
PI 3‐Kinase signaling: A journey in three AKTs (2022) (0)
Abstract 1400: SWI/SNF chromatin remodeling complex regulation of YAP-dependent enhancers drives therapeutic resistance in triple-negative breast cancer (2021) (0)
ADAM9 Isoforms in Breast Cancer Cell Migration (2009) (0)
Signal Transduction The Adherens Junction Protein Afadin Is an AKT Substrate that Regulates Breast Cancer Cell Migration (2014) (0)
Chapter 12 Cellular regulation of protein kinase C (2001) (0)
Faculty Opinions recommendation of mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability. (2017) (0)
Upstream Regulation of AKT PI 3 K-Dependent AKT Activation (2017) (0)
Abstract 4998: NFAT signaling modulates tumor microenvironment. (2013) (0)
Can open science follow open access? (2021) (0)
Can Improved Use of Biomarkers Alter the Fate of PI3K Pathway Inhibitors in the Clinic? (2021) (0)
A genetically‐encoded reporter reveals novel regulation of protein kinase D by calcium (2006) (0)
Faculty Opinions recommendation of Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. (2011) (0)
Faculty Opinions recommendation of Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations. (2010) (0)
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions (2019) (0)
Editorial Board (2009) (0)
Abstract ES6-2: PI3K in breast cancer, glutamine changes and methionine addiction (2019) (0)
Abstract 2634: Investigating the chemotherapeutic effects of aspirin in mutant PIK3CA breast cancer (2015) (0)
PTEN-DEFICIENT TUMORS DEPEND ON AKT 2 FOR MAINTENANCE AND 1 SURVIVAL 2 3 (2014) (0)
Molecular Cell Previews Akt-ingUponSRPK 1 : OncogeneorTumorSuppressor ? (0)
Faculty Opinions recommendation of RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. (2005) (0)
Faculty Opinions recommendation of Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines. (2008) (0)
Faculty Opinions recommendation of CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors. (2014) (0)
Faculty Opinions recommendation of Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines. (2021) (0)
Faculty Opinions recommendation of MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance. (2013) (0)
Faculty Opinions recommendation of Targeted therapy in patients with PIK3CA-related overgrowth syndrome. (2018) (0)
Regulation of Carcinoma Invasion by ADAMs and MMPs (2009) (0)
Functions of the p21-activated protein kinases (Paks) in neutrophils and their regulation by complex lipids. (1999) (0)
myo-Inositol Phosphates, Phosphoinositides and Signal Transduction, B. B. Biswas, S. Biswas (Eds.), in: Subcellular Biochemistry, Volume 26. Plenum Press (1996), 421 pages, ISBN: 0 306 45221 9 (1997) (0)
Faculty Opinions recommendation of Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors. (2009) (0)
Faculty Opinions recommendation of Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors. (2019) (0)
EFFECT OF OVEREXPRESSION OF PROTEIN KINASE Cα ON RAT LACRIMAL GLAND PROTEIN SECRETION. (2000) (0)
Endothelial Biomedicine: Protein Kinase C (2007) (0)
Breast Cancer Chemoresistance Mechanisms Through PI 3-Kinase and Akt Signaling (2015) (0)
Protein Kinase C in Cancer Signaling and Therapy: Introduction and Historical Perspective (2010) (0)
Abstract PL07-01: Molecular profiling of breast cancer in Mexico: Identification of novel therapeutic targets through whole genome sequencing analysis. (2012) (0)
WWP 1 inactivation enhances efficacy of PI 3 K inhibitors while suppressing their toxicities in breast cancer models (2021) (0)
Faculty Opinions recommendation of Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. (2015) (0)
Faculty Opinions recommendation of Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors. (2015) (0)

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