Alexander Dobrovic
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Alexander Dobrovic's Degrees
- Masters Artificial Intelligence Stanford University
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(Suggest an Edit or Addition)Alexander Dobrovic's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group. (2012) (993)
- Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation (2007) (472)
- Methylation of the BRCA1 gene in sporadic breast cancer. (1997) (389)
- Sequence artifacts in DNA from formalin-fixed tissues: causes and strategies for minimization. (2015) (366)
- A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer (2013) (352)
- Empirical array quality weights in the analysis of microarray data (2006) (300)
- High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer (2006) (295)
- Methylation-sensitive high-resolution melting (2008) (275)
- Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. (2009) (271)
- Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma (2011) (222)
- High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies (2008) (214)
- Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing (2014) (209)
- Distinct clinical and pathological features are associated with the BRAF(T1799A(V600E)) mutation in primary melanoma. (2005) (202)
- GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly (2017) (190)
- Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines (2014) (186)
- Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection (2008) (176)
- Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer (2007) (168)
- Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase (2012) (159)
- Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma (2018) (158)
- Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations (2015) (156)
- Molecular detection of blood‐borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease (2000) (156)
- Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer (2010) (147)
- DNA methylation biomarkers in cancer: progress towards clinical implementation (2012) (144)
- High resolution melting for mutation scanning of TP53 exons 5–8 (2007) (143)
- Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value (2015) (143)
- BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype (2008) (136)
- Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors (2014) (133)
- HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer (2010) (130)
- A new approach to primer design for the control of PCR bias in methylation studies (2008) (130)
- Combination Osimertinib and Gefitinib in C797S and T790M EGFR‐Mutated Non–Small Cell Lung Cancer (2017) (129)
- Immunobead-PCR: a technique for the detection of circulating tumor cells using immunomagnetic beads and the polymerase chain reaction. (1993) (128)
- The implications of heterogeneous DNA methylation for the accurate quantification of methylation. (2010) (127)
- Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer. (2000) (126)
- Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT (2010) (125)
- A multicenter blinded study to evaluate KRAS mutation testing methodologies in the clinical setting. (2009) (122)
- Detection of Circulating Tumor Cells in Colorectal Cancer by Immunobead-PCR Is a Sensitive Prognostic Marker for Relapse of Disease (1995) (115)
- BRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV Damage (2013) (114)
- BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival (2019) (109)
- Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure (2010) (109)
- Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer. (2012) (103)
- The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia. (1999) (101)
- Reducing sequence artifacts in amplicon-based massively parallel sequencing of formalin-fixed paraffin-embedded DNA by enzymatic depletion of uracil-containing templates. (2013) (99)
- The significance of oncogene amplification in primary breast cancer (1989) (95)
- Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver (2014) (91)
- A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma (2019) (90)
- Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis (2008) (90)
- Loss of red cell A, B, and H antigens is frequent in myeloid malignancies. (2001) (85)
- Nonequivalent Gene Expression and Copy Number Alterations in High-Grade Serous Ovarian Cancers with BRCA1 and BRCA2 Mutations (2013) (83)
- Detection of the molecular abnormality in chronic myeloid leukemia by use of the polymerase chain reaction. (1988) (81)
- Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers (2006) (81)
- Detection of BRAF mutations in patients with hairy cell leukemia and related lymphoproliferative disorders (2012) (78)
- DNA methylation, epimutations and cancer predisposition. (2009) (77)
- Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in advanced breast cancer (2012) (76)
- Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene (2008) (72)
- Variable promoter region CpG island methylation of the putative tumor suppressor gene Connexin 26 in breast cancer. (2002) (72)
- Role of p53 in the progression of gastric cancer (2014) (70)
- Limited copy number - high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies (2009) (67)
- Significance of molecular marker-positive cells after autologous peripheral-blood stem-cell transplantation for non-Hodgkin's lymphoma. (1995) (66)
- Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism (2009) (66)
- Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2) (2021) (65)
- Analysing DNA methylation using bisulphite pyrosequencing. (2011) (64)
- Assessing combined methylation–sensitive high resolution melting and pyrosequencing for the analysis of heterogeneous DNA methylation (2011) (62)
- Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer (2017) (60)
- DNA Methylation of the ABO Promoter Underlies Loss of ABO Allelic Expression in a Significant Proportion of Leukemic Patients (2009) (60)
- Immunobead RT-PCR: a sensitive method for detection of circulating tumor cells. (1997) (58)
- Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome (2014) (58)
- High Frequency of Germline TP53 Mutations in a Prospective Adult-Onset Sarcoma Cohort (2013) (56)
- Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia (2008) (56)
- Molecular detection of residual lymphoma cells in peripheral blood stem cell harvests and following autologous transplantation. (1993) (56)
- A new normalization for Nanostring nCounter gene expression data (2019) (55)
- Rapid detection of methylation change at H19 in human imprinting disorders using methylation‐sensitive high‐resolution melting (2008) (55)
- erbA-related sequence coding for DNA-binding hormone receptor localized to chromosome 3p21-3p25 and deleted in small cell lung carcinoma. (1988) (53)
- Methylation‐sensitive, single‐strand conformation analysis (MS‐SSCA): A rapid method to screen for and analyze methylation (1999) (51)
- BRAF inhibitor-driven tumor proliferation in a KRAS-mutated colon carcinoma is not overcome by MEK1/2 inhibition. (2013) (51)
- Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation (2001) (50)
- A rapid and reliable PCR method for genotyping the ABO blood group (1993) (50)
- Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting (2008) (48)
- Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients (2015) (48)
- TERT gene: its function and dysregulation in cancer (2019) (47)
- Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer (2017) (47)
- The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression (2011) (46)
- Molecular Genomic Profiling of Melanocytic Nevi. (2019) (45)
- Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers. (1989) (45)
- Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B‐Raf (2009) (45)
- Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours (2013) (45)
- Optimisation of the RT-PCR detection of immunomagnetically enriched carcinoma cells (2002) (42)
- Copy number analysis of ductal carcinoma in situ with and without recurrence (2015) (42)
- Somatic mutations, acetylator status, and prognosis in colorectal cancer (1998) (42)
- Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma (2014) (42)
- A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma (2013) (41)
- Validation of a primer optimisation matrix to improve the performance of reverse transcription – quantitative real-time PCR assays (2009) (41)
- Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals (2015) (41)
- Direct Genotyping of Single Nucleotide Polymorphisms in Methyl Metabolism Genes Using Probe-Free High-Resolution Melting Analysis (2008) (40)
- G1738R is a BRCA1 founder mutation in Greek breast/ovarian cancer patients: evaluation of its pathogenicity and inferences on its genealogical history (2008) (39)
- Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis. (2002) (38)
- TERT structural rearrangements in metastatic pheochromocytomas. (2018) (37)
- A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma (2014) (37)
- Fc-γ Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer (2016) (34)
- Identification of circulating tumour cells in early stage breast cancer patients using multi marker immunobead RT-PCR (2009) (34)
- The role of BRAF mutations in primary melanoma growth rate and survival (2015) (34)
- Cerebrospinal fluid liquid biopsy for detecting somatic mosaicism in brain (2021) (34)
- DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast (2010) (34)
- A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes (2011) (33)
- Molecular diagnosis of Philadelphia negative CML using the polymerase chain reaction and DNA analysis: clinical features and course of M-bcr negative and M-bcr positive CML. (1991) (33)
- Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes (2012) (33)
- Sensitive detection of KIT D816V in patients with mastocytosis. (2006) (32)
- Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors (2013) (32)
- A rapid and reliable PCR method for genotyping the ABO blood group. II: A2 and O2 alleles (1996) (31)
- Mismatch Repair Protein Defects and Microsatellite Instability in Malignant Pleural Mesothelioma (2018) (31)
- Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung (2010) (30)
- Nuclear HIF1A expression is strongly prognostic in sporadic but not familial male breast cancer (2014) (27)
- Temporal changes of EGFR mutations and T790M levels in tumour and plasma DNA following AZD9291 treatment. (2016) (26)
- Complete molecular response of e6a2 BCR-ABL-positive acute myeloid leukemia to imatinib then dasatinib. (2008) (26)
- Melting curve assays for DNA methylation analysis. (2009) (26)
- Bioinformatics Pipelines for Targeted Resequencing and Whole-Exome Sequencing of Human and Mouse Genomes: A Virtual Appliance Approach for Instant Deployment (2014) (26)
- Polyclonal Resistance in Gastrointestinal Stromal Tumor Treated with Sequential Kinase Inhibitors (2006) (25)
- Promoter region methylation does not account for the frequent loss of expression of the Fas gene in colorectal carcinoma (1999) (25)
- DNA methylation and genetic inactivation at thymidine kinase locus: Two different mechanisms for silencing autosomal genes (1988) (25)
- Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma (2014) (25)
- Localization of the human growth arrest-specific gene (GAS1) to chromosome bands 9q21.3-q22, a region frequently deleted in myeloid malignancies. (1993) (24)
- An optimised direct lysis method for gene expression studies on low cell numbers (2015) (23)
- Methylation profiling of ductal carcinoma in situand its relationship to histopathological features (2014) (23)
- A multiplex endpoint RT-PCR assay for quality assessment of RNA extracted from formalin-fixed paraffin-embedded tissues (2010) (23)
- A novel duplication polymorphism in the FANCA promoter and its association with breast and ovarian cancer (2005) (22)
- Screening for and analysis of methylation differences using methylation-sensitive single-strand conformation analysis. (2002) (22)
- PIK3CA mutations are frequently observed in BRCAX but not BRCA2 -associated male breast cancer (2013) (22)
- Somatic GNAQ mutation in the forme fruste of Sturge-Weber syndrome (2018) (22)
- Probe-Free Digital PCR Quantitative Methodology to Measure Donor-Specific Cell-Free DNA after Solid-Organ Transplantation. (2017) (22)
- Acquired RAD51C promoter methylation loss causes PARP inhibitor resistance in high grade serous ovarian carcinoma (2020) (21)
- Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations (2014) (21)
- The Clinical Relevance of Pathologic Subtypes in Metastatic Lung Adenocarcinoma (2014) (21)
- Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer (2011) (21)
- Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non–small cell lung cancer (2017) (21)
- The ( 4 ; 11 ) ( q 21 ; p 15 ) Translocation Fuses the NUP 98 and RAP 1 GDS 1 Genes and Is Recurrent in T-Cell Acute Lymphocytic Leukemia (1999) (20)
- DNA ligase-based strategy for quantifying heterogeneous DNA methylation without sequencing. (2015) (20)
- MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing (2016) (20)
- Docetaxel plus cetuximab as second-line treatment for docetaxel-refractory oesophagogastric cancer: the AGITG ATTAX2 trial (2013) (20)
- Investigating the Potential Role of Genetic and Epigenetic Variation of DNA Methyltransferase Genes in Hyperplastic Polyposis Syndrome (2011) (20)
- Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies (2016) (19)
- A simple, rapid, and sensitive method for the detection of the JAK2 V617F mutation. (2007) (19)
- Mapping of actionable mutations to histological subtype domains in lung adenocarcinoma: implications for precision medicine (2014) (19)
- The Measurement of Donor-Specific Cell-Free DNA Identifies Recipients With Biopsy-Proven Acute Rejection Requiring Treatment After Liver Transplantation (2019) (19)
- BRAF Mutations in Low-Grade Serous Ovarian Cancer and Response to BRAF Inhibition. (2018) (18)
- DNA methylation analysis of the HIF‐1α prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas (2010) (18)
- DNA methylation in ductal carcinoma in situ of the breast (2013) (18)
- Quantitative methodology is critical for assessing DNA methylation and impacts on correlation with patient outcome (2014) (18)
- No evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer (2009) (17)
- A frequent HindIII RFLP on chromosome 3p21-25 detected by a genomic erbA beta sequence. (1988) (17)
- Quantitative threefold allele-specific PCR (QuanTAS-PCR) for highly sensitive JAK2 V617F mutant allele detection (2013) (17)
- Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer (2011) (17)
- In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs (2008) (16)
- Methods for Analysis of DNA Methylation (2006) (16)
- LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness (2017) (16)
- Fc‐gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer (2018) (16)
- Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5. (1997) (15)
- Multicenter randomized, open‐label phase II trial of sequential erlotinib and gemcitabine compared with gemcitabine monotherapy as first‐line therapy in elderly or ECOG PS two patients with advanced NSCLC (2015) (15)
- Optimizing Amplification of the GC-Rich TERT Promoter Region Using 7-Deaza-dGTP for Droplet Digital PCR Quantification of TERT Promoter Mutations. (2018) (15)
- DNA Methylation Profiling of Breast Cancer Cell Lines along the Epithelial Mesenchymal Spectrum—Implications for the Choice of Circulating Tumour DNA Methylation Markers (2018) (14)
- Reducing Artifactual EGFR T790M Mutations in DNA from Formalin-Fixed Paraffin-Embedded Tissue by Use of Thymine-DNA Glycosylase. (2017) (14)
- Decreased stability of the O allele mRNA transcript of the ABO gene [letter] (1996) (14)
- Imprinting and loss of ABO antigens in leukemia. (1993) (14)
- Closed-tube PCR methods for locus-specific DNA methylation analysis. (2011) (14)
- Genomic Analysis of Circulating Tumor DNA Using a Melanoma-Specific UltraSEEK Oncogene Panel. (2019) (14)
- HER 3 and downstream pathways are involved in colonization of brain metastases from breast cancer (2010) (13)
- Associations between the IASLC/ATS/ERS lung adenocarcinoma classification and EGFR and KRAS mutations. (2016) (12)
- Decreased stability of the O allele mRNA transcript of the ABO gene. (1996) (12)
- Human-specific RNA analysis shows uncoupled epithelial-mesenchymal plasticity in circulating and disseminated tumour cells from human breast cancer xenografts (2019) (12)
- Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance (2021) (12)
- Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour (2015) (12)
- Characterization of a Novel Tumorigenic Esophageal Adenocarcinoma Cell Line: OANC1 (2013) (12)
- NTRK and ALK rearrangements in malignant pleural mesothelioma, pulmonary neuroendocrine tumours and non-small cell lung cancer. (2020) (12)
- The fusion partner specifies the oncogenic potential of NUP98 fusion proteins. (2013) (12)
- Clinical significance of genomic alterations of the CDK4-pathway and sensitivity to the CDK4 inhibitor PD 0332991 in melanoma. (2012) (12)
- KIT immunohistochemistry and mutation status in gastrointestinal stromal tumours (GISTs) evaluated for treatment with imatinib (2006) (11)
- BRCA2 carriers with male breast cancer show elevated tumour methylation (2017) (10)
- Biology of Human Tumors Genomic Classi fi cation of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP 53-Mutant Tumors and Identi fi es NRAS as an Oncogenic Driver (2014) (10)
- A rare translocation (4;11)(q21;p14-15) in an acute lymphoblastic leukemia expressing T-cell and myeloid markers. (1991) (10)
- Assessing gene-specific methylation using HRM-based analysis. (2011) (10)
- Methylation analysis of formalin-fixed, paraffin-embedded sections using a nontoxic DNA extraction protocol. (2001) (10)
- Sensitive quantitative detection of somatic mosaic mutation in "double cortex" syndrome. (2017) (10)
- Donor-specific cell-free DNA as a biomarker in liver transplantation: A review (2020) (10)
- Standard dose osimertinib for erlotinib refractory T790M-negative EGFR-mutant non-small cell lung cancer with leptomeningeal disease. (2019) (9)
- Assessing alternative base substitutions at primer CpG sites to optimise unbiased PCR amplification of methylated sequences (2017) (9)
- Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast (2015) (9)
- Elevated Plasma Levels of Cell‐Free DNA During Liver Transplantation Are Associated With Activation of Coagulation (2019) (8)
- “Cancer 2015”: A Prospective, Population-Based Cancer Cohort—Phase 1: Feasibility of Genomics-Guided Precision Medicine in the Clinic (2015) (8)
- Using tumour pathology to identify people at high genetic risk of breast and colorectal cancers (2012) (8)
- No evidence for PALB2 methylation in high-grade serous ovarian cancer (2013) (8)
- Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas (2015) (8)
- Non-equivalent gene expression and copy number alterations in high-grade serous ovarian cancers with BRCA1 and BRCA2 mutations (2013) (7)
- Negative selection of chronic lymphocytic leukaemia cells using a bifunctional rosette-based antibody cocktail (2008) (7)
- PDCD1 Polymorphisms May Predict Response to Anti-PD-1 Blockade in Patients With Metastatic Melanoma (2021) (7)
- Clustering of 1p36 breakpoints distal to 1p36.2 in hematological malignancies. (2001) (7)
- High Speed Centrifugation Before Frozen Storage of Plasma Is Critical for Quantitative Analysis of Mitochondrial-Derived Cell-Free DNA. (2020) (7)
- Pathological response of gastrointestinal stromal tumour to imatinib treatment correlates with tumour KIT mutational status in individual tumour clones (2006) (7)
- Sensitive quantification of somatic mutations using molecular inversion probes. (2011) (6)
- Comparison of 3 Methodologies for Genotyping of Small Deletion and Insertion Polymorphisms. (2016) (6)
- Digital PCR of Genomic Rearrangements for Monitoring Circulating Tumour DNA. (2016) (6)
- De novo activating epidermal growth factor mutations (EGFR) in small‐cell lung cancer (2017) (5)
- Detection of NPM 1 exon 12 mutations and FLT 3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia (2015) (5)
- Removing unwanted variation from large-scale RNA sequencing data with PRPS (2022) (5)
- Abstract 290: Constitutional BRCA1 methylation is a major predisposition factor for high-grade serous ovarian cancer (2014) (5)
- EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma (2017) (4)
- Rapid High-Throughput Methylation Analysis Using the LightCycler ® 480 System (2008) (4)
- Clinical outcome and pathologic features associated with NRAS mutation in cutaneous melanoma. (2010) (4)
- Methylation-sensitive High Resolution Melting for the Rapid Analysis of DNA Methylation (2011) (4)
- SCL gene in human tumors. (1992) (4)
- A Synthetic DNA Construct to Evaluate the Recovery Efficiency of Cell-Free DNA Extraction and Bisulfite Modification. (2021) (4)
- Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma (2021) (4)
- No evidence for DNA methylation of the ATM promoter CpG island in chronic lymphocytic leukemia (2012) (4)
- Elevated levels of circulating mitochondrial DNA predict early allograft dysfunction in patients following liver transplantation (2021) (4)
- A HindIII RFLP for the HPRT pseudogene on chromosome 3 (HPRTP1). (1987) (3)
- DUX study: A phase II study of evaluating dual targeting of the EGFR using the combination of cetuximab and erlotinib in patients with chemotherapy refractory metastatic colorectal cancer. (2010) (3)
- BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival (2019) (3)
- Rapid detection of FLT3 exon 20 tyrosine kinase domain mutations in patients with acute myeloid leukemia by high-resolution melting analysis (2012) (3)
- Comment on: “Hypoxia differently modulates the release of mitochondrial and nuclear DNA” (2021) (3)
- Fresh Frozen Plasma Transfusion Can Confound the Analysis of Circulating Cell-Free DNA. (2018) (3)
- Relationship between M-BCR breakpoint position in blast crisis and length of chronic phase in chronic myeloid leukemia. (1992) (3)
- Germline Polymorphisms as Biomarkers of Tumor Response in Colorectal Cancer Patients Treated with Anti-EGFR Monoclonal Antibodies: A Systematic Review and Meta-Analysis (2016) (3)
- Donor-specific cell-free DNA as a non-invasive marker of organ rejection after liver transplantation: A pilot study (2016) (3)
- Novel Methods for the Sensitive Detection of c-KIT D816V and Other Exon 17 Mutations in Patients with Mastocytosis. (2005) (3)
- Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat (2015) (2)
- DNA Breathing Enables Closed-Tube Mutant Allele Enrichment for Circulating Tumor DNA Analysis. (2017) (2)
- Analysis of DNA Methylation in Clinical Samples: Methods and Applications (2016) (2)
- Nuclear and cytoplasmic localisation of the leukemia associated NUP98-RAP1GDS1 fusion protein. (2000) (2)
- Epigenetic Basis of Human Cancer (2017) (2)
- Epigenetic Basis of Human Cancer (2017) (2)
- Characterization of a RAD51C-Silenced High Grade Serous Ovarian Cancer Model During PARP Inhibitor Resistance Development (2020) (2)
- Abstract A25: BRAFV600E mutations in serous ovarian cancer and response to the BRAF inhibitor, dabrafenib. (2016) (2)
- Adapting an Established Clinical Chemistry Quality Control Measure for Droplet Generation Performance in Digital PCR. (2018) (2)
- A new normalization for the Nanostring nCounter gene expression assay (2018) (2)
- Improved Normalization of Nanostring nCounter Gene Expression Data (2018) (2)
- Abstract P1-05-03: Predictive value of de novo and induced epithelial-mesenchymal transition in locally advanced breast cancer treated with neoadjuvant chemotherapy (2016) (2)
- No evidence for DNA methylation of von Hippel-Lindau ubiquitin ligase complex genes in breast cancer (2010) (2)
- Analysis of DNA Methylation in Clinical Samples: Methods and Applications (2016) (2)
- Analysis of DNA Methylation in Clinical Samples: Methods and Applications (2016) (2)
- Differential Mechanisms of CDKN2A (p16) Inactivation in Oral Tongue Squamous Cell Carcinomas and Correlation With Patient Outcome (2014) (2)
- High-resolution assessment of copy number variation. (2015) (2)
- Mapping of the chromosome 11 breakpoint of the t(4;11)(q21;p14-15) translocation. (1993) (2)
- Erratum: An optimised direct lysis method for gene expression studies on low cell numbers (2017) (2)
- Expression is a Frequent Event in Primary Invasive Melanoma and Correlates with Sensitivity to the CDK 4 / 6 Inhibitor PD 0332991 in Melanoma Cell Lines (2014) (2)
- Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas (2016) (1)
- Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour (2015) (1)
- Development and validation of a novel quantitative BRCA1 promoter methylation assay in ovarian carcinoma (2022) (1)
- 1.30 Caspase 10 is Down-Regulated in Chronic Lymphocytic Leukemia (2011) (1)
- Methylation of the BRCAJ Gene in Sporadic Breast Cancer (1997) (1)
- Quantitative threefold allele-specific PCR (QuanTAS-PCR) for highly sensitive JAK2V617F mutant allele detection (2013) (1)
- Quantitative methodology is critical for assessing DNA methylation and impacts on correlation with patient outcome (2014) (1)
- High resolution melting allows sensitive high-throughput assessment of methylation in tumour samples (2008) (1)
- Abstract 113: Aberrant DNA methylation of the HIF-1α inhibitor gene CITED4 in breast cancer (2011) (1)
- Clustered somatic mutations are frequent in transcription factor binding sites in melanoma and other cutaneous malignancies. (2016) (1)
- wild-type melanomas have a high mutation load correlating with histological and molecular signatures of UV damage (2013) (1)
- DNA methylation in ductal carcinoma in situof the breast (2013) (1)
- BRCA2 carriers with male breast cancer show elevated tumour methylation (2017) (1)
- Publisher Correction: A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma (2020) (1)
- Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses (2021) (1)
- MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing (2016) (1)
- 57. Detection of circulating tumour cells in patients with breast cancer using immunobead-PCR (1995) (1)
- Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma (2018) (1)
- Low Levels of Hepatocyte‐Specific Methylation in Cell‐Free DNA Are a Strong Negative Predictor for Acute T Cell–Mediated Rejection Requiring Treatment Following Liver Transplantation (2021) (1)
- Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors (2013) (1)
- Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast (2015) (1)
- Molecular analysis of the Philadelphia chromosome. (1991) (1)
- Connexin 26 is methylated in a high proportion of breast cancer patients (2000) (1)
- Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing (2014) (1)
- Methylation profiling of ductal carcinoma in situand its relationship to histopathological features (2014) (1)
- Publisher Correction: A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma (2020) (1)
- Donor-Specific Cell-Free DNA as an Emerging Biomarker of Organ Rejection after Liver Transplantation (2018) (1)
- CIRCULATING AND DISSEMINATED TUMOR CELLS IN BREAST CANCER (2016) (1)
- of the polymerase chain reaction Detection of the molecular abnormality in chronic myeloid leukemia by use (2011) (1)
- EGFR gene copy number alterations are not a useful screening tool for predicting EGFR mutation status in lung adenocarcinoma (2014) (1)
- Abstract 2962: LRH-1 expression in breast cancer tissue and its association with phenotype and DNA methylation (2015) (1)
- DNA methylation profiling of breast cancer cell lines along the epithelial mesenchymal spectrum - implications for the choice of circulating tumour DNA methylation markers (2017) (1)
- PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer (2013) (1)
- White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk: A Perspective (2018) (1)
- Abstract LB-377: Promoter methylation of the DAPK1 CLL predisposition gene is associated with chronic lymphocytic leukaemia risk (2012) (0)
- T1715 The Role of Genetic and Epigenetic Variation of DNA Methyltransferases in Hyperplastic Polyposis Syndrome (2010) (0)
- NTRK and ALK rearrangements in mesothelioma and lung carcinoid. (2018) (0)
- In Reply to Leone. (2018) (0)
- Gene expression profiling of T-cell inflammation in small cell lung cancer. (2019) (0)
- Loss of ABO antigens in myeloid malignancies (2000) (0)
- P1.16-11 Monitoring of Early Stage Lung Cancer Using Liquid Biopsies (2018) (0)
- Abstract 4693: Characterization of the differential mechanisms ofCDKN2Ainactivation in oral tongue squamous cell carcinomas and correlation with patient outcome. (2013) (0)
- 1.29 Development of Highly Accurate RT-qPCR Assays for Profiling the Expression of DNA Repair and Apoptosis Genes in CLL (2011) (0)
- Investigating epithelial-mesenchymal plasticity in circulating tumour cells from breast cancer xenograft models (2016) (0)
- Predicting Breast Cancer Risk by Assaying Peripheral Blood Methylation. Addendum (2007) (0)
- Human Cancer Biology BRAF / NRAS Wild-Type Melanomas Have a High Mutation LoadCorrelatingwith Histologic andMolecular Signatures of UV Damage (2013) (0)
- TP53 Mutations In Relapsed/Refractory Multiple Myeloma (MM) Treated with Thalidomide (Thal) or Thalidomide Combination Therapy (2010) (0)
- DNA repair gene inactivation in non-Hodgkin's lymphoma (2006) (0)
- Profiling DNA Repair in Lung Cancer (2017) (0)
- Abstract IA02: DNA repair gene promoter methylation patterns adapt and influence PARP inhibitor response (2020) (0)
- Sensitive detection of TERT promoter mutations reveals early acquisition and heterogeneity in cutaneous melanoma (2017) (0)
- Quantification of Graft-Derived Cell-Free DNA during Normothermic Machine Perfusion in Liver Transplantation Is Feasible and May Be a Useful Future Tool for Assessing Organ Health (2022) (0)
- Detection of minimal residual tumour cells in stem cell harvests using molecular markers (1991) (0)
- A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma (2019) (0)
- In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs (2009) (0)
- Assessing alternative base substitutions at primer CpG sites to optimise unbiased PCR amplification of methylated sequences (2017) (0)
- Abstract 823: A case-control study of constitutionalBRCA1methylation in a mammographically screened cohort (2019) (0)
- Human-specific RNA analysis shows uncoupled epithelial-mesenchymal plasticity in circulating and disseminated tumour cells from human breast cancer xenografts (2019) (0)
- Liquid Biopsies in BRAF Mutant Melanoma: A New Frontier in Monitoring Response to Therapy (2017) (0)
- Evaluating DNA recovery efficiency following bisulphite modification from plasma samples submitted for cell-free DNA methylation analysis (2022) (0)
- The BRAF (T1799A) mutation is associated with distinct clinical characteristics in invasive primary melanoma (2005) (0)
- LIQUID BIOPSIES FROM SOLID TUMORS (2016) (0)
- Reassessing Locus-Specific DNA Methylation in Head-and-Neck Squamous Cell Carcinoma (HNSCC) With Quantitative Methodology and Correlation With Patient Outcome (2014) (0)
- Publisher Correction: Homologous recombination DNA repair defects in PALB2-associated breast cancers (2019) (0)
- Dna methylation – Is it ready for prime time in genetic pathology? (2020) (0)
- Clinical Utility of Real-Time Targeted Molecular Profiling in the Clinical Management of Ovarian Cancer: The ALLOCATE Study. (2019) (0)
- Clinical Utility of Real-Time Targeted Molecular Profiling in the Clinical Management of Ovarian Cancer: The ALLOCATE Study. (2019) (0)
- Evaluating treatment response following locoregional therapy for hepatocellular carcinoma: A review of the available serological and radiological tools for assessment (2023) (0)
- Abstract 5885: Loss of RAD51C promoter hypermethylation confers PARP inhibitor resistance (2018) (0)
- Can mammographic breast density predict complete pathological response in patients with locally advanced breast cancer following neoadjuvant chemotherapy (2018) (0)
- Melanoma pigmentation affects melanoma-specific survival and provides a potential target for radiopharmaceutical-based imaging and therapy. (2011) (0)
- Abstract 2098: Reducing sequence artefacts from FFPE DNA for cancer diagnostics (2012) (0)
- leukemogenesis Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to (2013) (0)
- Abstract B35: Australian Ovarian Cancer Assortment Trial–Allocating ovarian cancer patients into clinical trials based on molecular profiling (2018) (0)
- BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance (2023) (0)
- Epithelial mesenchymal transition, stromal density, and chemo-resistance in breast cancer (BrCa) (2019) (0)
- 1.31 Investigating Methylation of the Pro-Apoptotic CLL Tumour Suppressor Gene, Death Associated Protein Kinase 1 (DAPK1) (2011) (0)
- Homologous recombination DNA repair defects in PALB2-associated breast cancers (2019) (0)
- Abstract 2977: Epithelial mesenchymal plasticity in xenograft models of circulating and disseminated tumour cells from human breast cancer (2012) (0)
- Evaluation of Different Oligonucleotide Base Substitutions at CpG Binding sites in Multiplex Bisulfite-PCR sequencing (2017) (0)
- P3.02-038 Diagnosis of Leptomeningeal Disease and Clonal Heterogeneity with Digital Droplet PCR (ddPCR) in EGFR Mutated NSCLC (2017) (0)
- P1.02-012 Profiling DNA Repair in Lung Cancer (2017) (0)
- Abstract 383: Is loss of MGMT a therapeutic target in lung cancer (2014) (0)
- Localization of the chromosome 11 breakpoint in a translocation t(4;11)(q21;p15) in T cell acute lymphocytic leukemia (T-ALL) (1994) (0)
- Review: Molecular analysis of the Philadelphia chromosome (1991) (0)
- The "Adelaide Chromosome" - A new recurrent translocation T(4;11) (Q21;P15) in T-cell all involves the NUP98 and RAP1GDS1 genes (2000) (0)
- Significant Numbers of Irradiated Tumor Cells Enter the Circulation Early During a Course of Fractionated Radiation Therapy for Non-small Cell Lung Cancer (2012) (0)
- Fusion of the NUP98 and RAP1GDS1 genes results in a protein localising to the nucleus (2000) (0)
- The Development of a Tissue Methylation-Specific Cell Free DNA Biomarker for Organ Rejection Following Liver Transplantation (2021) (0)
- Molecular Genomic Profiling of Melanocytic Nevi (2019) (0)
- The BRAF (T1799A) mutation in melanoma is associated with tumour pigmentation but not rate of proliferation (2005) (0)
- The Association of FCGR2A and FCGR3A polymorphisms with outcomes in cetuximab treated metastatic colorectal cancer patients: CCTG and AGITG CO.20 trial analysis. (2018) (0)
- CANDIDATE METHYLATION PROFILING OF DUCTAL CARCINOMA IN SITU AND ITS RELATIONSHIP TO PHENOTYPE (2014) (0)
- Abstract P5-08-05: The interplay between stromal density, epithelial mesenchymal transition and chemoresistance in breast cancer (2019) (0)
- A rapid and reliable PCR method for genotyping the ABO blood group. (1994) (0)
- The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer (2019) (0)
- Removing unwanted variation from large-scale cancer RNA-sequencing data (2021) (0)
- Abstract 823: A case-control study of constitutional BRCA1 methylation in a mammographically screened cohort (2019) (0)
- CPG island microarrays: A tool for detecting methylation changes in cancer (2000) (0)
- Abstract 54: Marked reduction of sequence artifacts in massively parallel sequencing of formalin-fixed paraffin-embedded DNA by depletion of uracil containing templates. (2013) (0)
- Targeting homologous recombination deficiency in uterine leiomyosarcoma (2023) (0)
- Mutation analysis for systemic mastocytosis (2011) (0)
- Reassessing Locus-Specific DNA Methylation in Head-and-Neck Squamous Cell Carcinoma (HNSCC) With Quantitative Methodology and Correlation With Patient Outcome (2014) (0)
- 245 Incorporating Epithelial Mesenchymal Plasticity (EMP) in the Detection and Isolation of Circulating and Disseminated Tumour Cells (2012) (0)
- Fusion of the NUP98 and RAP1GDS1 genes is recurrent in T-cell acute lymphocytic leukaemia and results in a fusion protein localising to the nucleus (2000) (0)
- P3-002: High resolution melting analysis for rapid and sensitive EGFR mutation detection (2007) (0)
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