Alexander Klibanov

Alexander Klibanov 's AcademicInfluence.com Rankings

Alexander Klibanov

Chemistry

#387

World Rank

#728

Historical Rank

#185

USA Rank

Organic Chemistry

#79

World Rank

#112

Historical Rank

#33

USA Rank

chemistry Degrees

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Chemistry

Alexander Klibanov 's Degrees

Bachelors Chemistry University of California, Berkeley
PhD Chemical Biology Stanford University

Why Is Alexander Klibanov Influential?

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According to Wikipedia, Alexander Klibanov is the Novartis Professor of Biological Engineering and Chemistry at the Massachusetts Institute of Technology and a member of the National Academy of Sciences. He was also elected a member of the National Academy of Engineering for research in enzyme and protein technology and contributions to the field of biocatalysis in nonaqueous solvents.

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Alexander Klibanov 's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Improving enzymes by using them in organic solvents (2001) (1861)
Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis (2005) (1248)
Designing surfaces that kill bacteria on contact (2001) (1021)
Ultrahigh-throughput screening in drop-based microfluidics for directed evolution (2010) (982)
Enzymatic catalysis in organic media at 100 degrees C. (1984) (941)
Enzyme-catalyzed processes in organic solvents. (1985) (920)
Enzymatic catalysis in nonaqueous solvents. (1988) (888)
The effect of water on enzyme action in organic media. (1988) (837)
Asymmetric transformations catalyzed by enzymes in organic solvents (1990) (828)
Enzymatic catalysis in anhydrous organic solvents. (1989) (708)
Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres (2004) (691)
Why are enzymes less active in organic solvents than in water? (1997) (635)
Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells (2003) (500)
Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces. (1991) (495)
Non-viral gene therapy: polycation-mediated DNA delivery (2003) (462)
Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells (2002) (459)
Resolution of racemic mixtures via lipase catalysis in organic solvents (1985) (448)
Stabilization of enzymes against thermal inactivation. (1983) (425)
Peroxidase-Catalyzed Removal of Phenols from Coal-Conversion Waste Waters (1983) (422)
Protease-catalyzed regioselective esterification of sugars and related compounds in anhydrous dimethylformamide (1988) (413)
Immobilized Enzymes and Cells as Practical Catalysts (1983) (411)
The mechanisms of irreversible enzyme inactivation at 100C. (1985) (363)
Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. (2005) (361)
Enzyme stabilization by immobilization. (1979) (361)
On Protein Denaturation in Aqueous−Organic Mixtures but Not in Pure Organic Solvents (1996) (353)
Facile enzymatic preparation of monoacylated sugars in pyridine (1986) (339)
Polymerization of phenols catalyzed by peroxidase in nonaqueous media (1987) (318)
Lyophilization-induced reversible changes in the secondary structure of proteins. (1995) (309)
How can the solvent affect enzyme enantioselectivity (1991) (308)
Permanently microbicidal materials coatings (2007) (298)
Polymer surfaces derivatized with poly(vinyl-N-hexylpyridinium) kill airborne and waterborne bacteria. (2002) (296)
The solvent dependence of enzyme specificity. (1994) (292)
Enzymatic reactions in organic media (1996) (289)
Surpassing nature: rational design of sterile-surface materials. (2005) (284)
Immobilized N-alkylated polyethylenimine avidly kills bacteria by rupturing cell membranes with no resistance developed. (2005) (279)
Mechanism of bactericidal and fungicidal activities of textiles covalently modified with alkylated polyethylenimine. (2003) (271)
Protein stability in controlled-release systems (2000) (263)
Polymeric coatings that inactivate both influenza virus and pathogenic bacteria (2006) (255)
Moisture‐induced aggregation of lyophilized proteins in the solid state (1991) (253)
Why does ribonuclease irreversibly inactivate at high temperatures? (1986) (246)
Bactericidal Properties of Flat Surfaces and Nanoparticles Derivatized with Alkylated Polyethylenimines (2002) (234)
Cross-linked Small Polyethylenimines: While Still Nontoxic, Deliver DNA Efficiently to Mammalian Cells in Vitro and in Vivo (2005) (230)
Preparative production of optically active esters and alcohols using esterase-catalyzed stereospecific transesterification in organic media (1984) (228)
Regioselective acylation of secondary hydroxyl groups in sugars catalyzed by lipases in organic solvents (1987) (224)
Regioselective oxidation of phenols catalyzed by polyphenol oxidase in chloroform (1985) (221)
The principles of enzyme stabilization. I. Increase in thermostability of enzymes covalently bound to a complementary surface of a polymer support in a multipoint fashion. (1977) (215)
Substrate specificity of enzymes in organic solvents vs. water is reversed (1986) (208)
Enzymatic reactions in supercritical gases (1985) (199)
Enzyme thermoinactivation in anhydrous organic solvents (1991) (199)
Mechanism of insulin aggregation and stabilization in agitated aqueous solutions (1992) (197)
Control of enzyme enantioselectivity by the reaction medium (1988) (197)
Mechanisms of irreversible thermal inactivation of Bacillus alpha-amylases. (1988) (196)
A new approach to preparative enzymatic synthesis (1977) (194)
FTIR characterization of the secondary structure of proteins encapsulated within PLGA microspheres. (1999) (193)
Enzyme‐Catalyzed Processes in Organic Solvents (1987) (187)
Enzymatic removal of toxic phenols and anilines from waste waters (1980) (185)
Horseradish peroxidase for the removal of carcinogenic aromatic amines from water (1981) (185)
Dephenolization of industrial wastewaters catalyzed by polyphenol oxidase (1984) (184)
Enzymic resolution of racemic amines: crucial role of the solvent (1989) (184)
Dramatic enhancement of enzymatic activity in organic solvents by lyoprotectants (1993) (181)
Enzyme crystal structure in a neat organic solvent. (1994) (178)
Thermal destruction processes in proteins involving cystine residues. (1987) (177)
Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes (2005) (176)
Why is one Bacillus alpha-amylase more resistant against irreversible thermoinactivation than another? (1988) (168)
Inversion of enzyme enantioselectivity mediated by the solvent (1992) (165)
Solid-phase aggregation of proteins under pharmaceutically relevant conditions. (1994) (162)
Enzymatic analyses in organic solvents (1986) (161)
Structure, thermostability, and conformational flexibility of hen egg-white lysozyme dissolved in glycerol. (1999) (158)
Inhibitor-induced enzyme activation in organic solvents. (1988) (157)
Comparison of different strategies for the lipase‐catalyzed preparative resolution of racemic acids and alcohols: Asymmetric hydrolysis, esterification, and transesterification (1984) (152)
Production of biosurfactants from sugar alcohols and vegetable oils catalyzed by lipases in a nonaqueous medium (1988) (145)
One‐Step, Painting‐Like Coating Procedures To Make Surfaces Highly and Permanently Bactericidal (2006) (145)
Moisture-Induced Aggregation of Lyophilized Insulin (2004) (143)
Hydrophobic polycationic coatings that inhibit biofilms and support bone healing during infection. (2012) (142)
THE MECHANISTIC DISSECTION OF THE PLUNGE IN ENZYMATIC ACTIVITY UPON TRANSITION FROM WATER TO ANHYDROUS SOLVENTS (1996) (142)
Peptide synthesis catalyzed by lipases in anhydrous organic solvents (1987) (141)
Stability of Proteins and Their Delivery from Biodegradable Polymer Microspheres (1996) (138)
Solvent variation inverts substrate specificity of an enzyme (1993) (136)
Asymmetric oxidoreductions catalyzed by alcohol dehydrogenase in organic solvents (1986) (133)
Insights into bactericidal action of surface-attached poly(vinyl-N-hexylpyridinium) chains (2002) (131)
Correct protein folding in glycerol. (1997) (130)
Incorporation of D-amino acids into peptides via enzymic condensation in organic solvents (1987) (123)
On protein solubility in organic solvent. (1994) (117)
Stabilization of tetanus and diphtheria toxoids against moisture-induced aggregation. (1995) (114)
A potential approach for decreasing the burst effect of protein from PLGA microspheres. (2003) (113)
Polyethylenimine-conjugated gold nanoparticles: Gene transfer potential and low toxicity in the cornea. (2011) (113)
Fourier-transform infrared spectroscopic investigation of protein stability in the lyophilized form. (1995) (112)
Measurement and Control (1993) (111)
Remarkable activation of enzymes in nonaqueous media by denaturing organic cosolvents (2000) (110)
Can conformational changes be responsible for solvent and excipient effects on the catalytic behavior of subtilisin Carlsberg in organic solvents? (1997) (110)
Dual functional polyelectrolyte multilayer coatings for implants: permanent microbicidal base with controlled release of therapeutic agents. (2010) (109)
Effect of the solvent on enzyme regioselectivity (1991) (109)
Nanocrystals modified with peptide nucleic acids (PNAs) for selective self-assembly and DNA detection. (2003) (109)
Akt-Mediated Transactivation of the S1P1 Receptor in Caveolin-Enriched Microdomains Regulates Endothelial Barrier Enhancement by Oxidized Phospholipids (2009) (108)
Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions. (2010) (107)
The principles of enzyme stabilization. II. Increase in the thermostability of enzymes as a result of multipoint noncovalent interaction with a polymeric support. (1977) (107)
Aggregation of a Lyophilized Pharmaceutical Protein, Recombinant Human Albumin: Effect of Moisture and Stabilization by Excipients (1995) (104)
Selection of horseradish peroxidase variants with enhanced enantioselectivity by yeast surface display. (2007) (103)
Enzymic peptide synthesis via segment condensation in the presence of water mimics (1989) (100)
Lipase-catalyzed acyiation of sugars solubilized in hydrophobic solvents by complexation. (1993) (98)
Non-viral siRNA delivery to the lung☆ (2007) (98)
Analysis of processes causing thermal inactivation of enzymes. (1988) (97)
On the role of reversible denaturation (unfolding) in the irreversible thermal inactivation of enzymes (1983) (97)
Preparation, application and testing of permanent antibacterial and antiviral coatings (2007) (97)
Enzymatic oxidation of ethanol in the gaseous phase (1989) (94)
Drastically lowered protein adsorption on microbicidal hydrophobic/hydrophilic polyelectrolyte multilayers. (2012) (94)
Control of oligomeric enzyme thermostability by protein engineering. (1987) (93)
Hydrophobic salts markedly diminish viscosity of concentrated protein solutions (2011) (92)
On the pH memory of lyophilized compounds containing protein functional groups. (1997) (92)
Striking activation of oxidative enzymes suspended in nonaqueous media. (1999) (90)
Structural stability of DNA in nonaqueous solvents (2000) (90)
BMP7 Gene Transfer via Gold Nanoparticles into Stroma Inhibits Corneal Fibrosis In Vivo (2013) (88)
Asymmetric enzymatic oxidoreductions in organic solvents. (2003) (85)
Structure of lysozyme dissolved in neat organic solvents as assessed by NMR and CD spectroscopies. (1999) (85)
What is remembered and why? (1995) (85)
Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations (2010) (84)
Preparative regioselective acylation of glycols by enzymatic transesterification in organic solvents (1985) (80)
Mechanistic studies on aggregation of polyethylenimine-DNA complexes and its prevention. (2005) (80)
Assessing the structural integrity of a lyophilized protein in organic solvents (1995) (80)
The principles of enzyme stabilization. III. The effect of the length of intra-molecular cross-linkages on thermostability of enzymes. (1978) (79)
Are water-immiscibility and apolarity of the solvent relevant to enzyme efficiency? (1993) (77)
PH CONTROL OF THE CATALYTIC ACTIVITY OF CROSS-LINKED ENZYME CRYSTALS IN ORGANIC SOLVENTS (1996) (77)
X-ray crystal structure of cross-linked subtilisin Carlsberg in water vs. acetonitrile. (1994) (75)
Marked dependence of enzyme prochiral selectivity on the solvent (1993) (75)
Stereoselective oligomerizations catalyzed by lipases in organic solvents (1987) (75)
Enzyme-catalyzed, gas-phase reactions (1987) (74)
Molecular imprinting of proteins and other macromolecules resulting in new adsorbents (1992) (74)
Preparative hydroxylation of aromatic compounds catalyzed by peroxidase (1981) (72)
Solid-state NMR assessment of enzyme active center structure under nonaqueous conditions. (1992) (71)
Cloning of an organic solvent-resistance gene in Escherichia coli: the unexpected role of alkylhydroperoxide reductase. (1995) (70)
Enzymatic removal of bilirubin from blood: a potential treatment for neonatal jaundice. (1985) (70)
On the issue of interfacial activation of lipase in nonaqueous media (1996) (70)
Peroxidases depolymerize lignin in organic media but not in water. (1986) (70)
The principles of enzyme stabilization. IV. Modification of 'key' functional groups in the tertiary structure of proteins. (1979) (68)
Rational Control of Enzymatic Enantioselectivity through Solvation Thermodynamics (1996) (66)
Improving biomaterial properties of collagen films by chemical modification. (2001) (65)
The crystal structure of subtilisin Carlsberg in anhydrous dioxane and its comparison with those in water and acetonitrile. (1997) (64)
Preparation of various glucose esters via lipase-catalyzed hydrolysis of glucose pentaacetate. (1987) (64)
Reusable evanescent wave DNA biosensor for rapid, highly sensitive, and selective detection of mercury ions. (2011) (63)
Antibody-antigen binding in organic solvents. (1989) (62)
Hammett analysis of enzyme action in organic solvents (1989) (61)
On enzymatic activity in organic solvents as a function of enzyme history. (1998) (61)
On the mechanism of irreversible thermoinactivation of enzymes and possibilities for reactivation of "irreversibly" inactivated enzymes. (1978) (61)
Prediction of the Solvent Dependence of Enzymatic Prochiral Selectivity by Means of Structure-Based Thermodynamic Calculations (1996) (61)
Production of abiotic receptors by molecular imprinting of proteins. (1990) (60)
Identification of Novel Superior Polycationic Vectors for Gene Delivery by High-throughput Synthesis and Screening of a Combinatorial Library (2007) (60)
Enzymochemical regioselective oxidation of steroids without oxidoreductase (1988) (60)
Solid‐State nuclear magnetic resonance investigation of solvent dependence of tyrosyl ring motion in an enzyme (1993) (59)
The secondary structure and aggregation of lyophilized tetanus toxoid. (1996) (59)
Selective acylation of peptides catalyzed by lipases in organic solvents (1991) (58)
Making thin polymeric materials, including fabrics, microbicidal and also water-repellent (2003) (57)
Horseradish peroxidase catalyzed hydroxylations: mechanistic studies. (1986) (57)
Highly l and d enantioselective variants of horseradish peroxidase discovered by an ultrahigh-throughput selection method (2008) (56)
Bio-Based Industrial Products: Priorities for Research and Commercialization (2000) (56)
Inactivation and stabilization of stabilisins in neat organic solvents (1991) (56)
Correlation between catalytic activity and secondary structure of subtilisin dissolved in organic solvents. (1997) (54)
Protein Structure in the Lyophilized State: A Hydrogen Isotope Exchange/NMR Study with Bovine Pancreatic Trypsin Inhibitor (1994) (54)
Mechanism of thermoinactivation of immobilized glucose isomerase (1989) (54)
Structure-Activity Relationship for Hydrophobic Salts as Viscosity-Lowering Excipients for Concentrated Solutions of Monoclonal Antibodies (2012) (53)
Atrial natriuretic peptide attenuates LPS-induced lung vascular leak: role of PAK1. (2010) (53)
Enzymatic synthesis of formic acid from H2 and CO2 and production of hydrogen from formic acid (1982) (53)
Demonstration of structural integrity of an enzyme in organic solvents by solid-state NMR (1989) (52)
Subunit interface of triosephosphate isomerase: site-directed mutagenesis and characterization of the altered enzyme. (1987) (52)
Enzymatic production of high fructose corn syrup (HFCS) containing 55% fructose in aqueous ethanol. (1987) (52)
Inhalation delivery of proteins from ethanol suspensions (2001) (51)
Gel Microdroplets: Rapid Detection and Enumeration of Individual Microorganisms by their Metabolic Activity (1988) (50)
Biocompatibility and biofilm inhibition of N,N-hexyl,methyl-polyethylenimine bonded to Boston Keratoprosthesis materials. (2011) (50)
The influence of the mode of enzyme preparation on enzymatic enantioselectivity in organic solvents and its temperature dependence (2000) (46)
Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses (2008) (46)
Specificity of a DNA-based (DNAzyme) peroxidative biocatalyst (2007) (44)
Comparison of x-ray crystal structures of an acyl-enzyme intermediate of subtilisin Carlsberg formed in anhydrous acetonitrile and in water. (1998) (44)
Lipase-catalyzed production of optically active acids via asymmetric hydrolysis of esters (1984) (44)
Oxidation of Dibenzothiophene Catalyzed by Hemoglobin and Other Hemoproteins in Various Aqueous-Organic Media (1992) (43)
Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection (2012) (43)
Controling the rate of protein release from polyelectrolyte complexes. (2003) (43)
Preparative production of hydroquinone from benzoquinone catalysed by immobilized d-glucose oxidase (1982) (43)
MARKEDLY ENHANCING ENZYMATIC ENANTIOSELECTIVITY IN ORGANIC SOLVENTS BY FORMING SUBSTRATE SALTS (1999) (42)
Light-activated covalent coating of cotton with bactericidal hydrophobic polycations. (2011) (42)
Highly Effective Gene Transfection In Vivo by Alkylated Polyethylenimine (2011) (41)
Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza a virus. (2010) (41)
Practical Aspects of Hydrophobic Polycationic Bactericidal “Paints” (2008) (40)
Transport of proteins dissolved in organic solvents across biomimetic membranes. (1995) (40)
Deterioration of lyophilized pharmaceutical proteins. (1998) (40)
Hydrophobic polycationic coatings disinfect poliovirus and rotavirus solutions. (2010) (40)
A colorimetric method for the enzymatic analysis of gases: the determination of ethanol and formaldehyde vapors using solid alcohol oxidase. (1989) (39)
Peroxidase-catalyzed asymmetric sulfoxidation in organic solvents versus in water. (2000) (39)
Chemoselective enzymic monoacylation of bifunctional compounds (1989) (38)
Stereospecific oxidation of aliphatic alcohols catalyzed by galactose oxidase. (1982) (37)
A rationale for stabilization of oxygen-labile enzymes: application to a clostridial hydrogenase. (1978) (37)
Approaches to enzyme stabilization. (1983) (37)
Computational prediction of native protein ligand-binding and enzyme active site sequences. (2005) (37)
Antiviral and Antibacterial Polyurethanes of Various Modalities (2013) (36)
Enzymatic Removal of Hazardous Pollutants from Industrial Aqueous Effluents (1982) (35)
Structural basis for the molecular memory of imprinted proteins in anhydrous media (2000) (35)
Effect of support material and enzyme pretreatment on enantioselectivity of immobilized subtilisin in organic solvents. (1994) (34)
Novel desiccants based on designed polymeric blends (2001) (34)
Bifunctional Polymeric Inhibitors of Human Influenza A Viruses (2010) (34)
Computer‐assisted modeling of subtilisin enantioselectivity in organic solvents (1992) (33)
Predicting the solvent dependence of enzymatic substrate specificity using semiempirical thermodynamic calculations (1993) (33)
On the relationship between conformation and stability in solid pharmaceutical protein formulations (2004) (33)
Protein separation and purification in neat dimethyl sulfoxide. (1991) (32)
An immobilized enzyme reactor for the detoxification of bilirubin (1986) (32)
Why inhaling salt water changes what we exhale. (2007) (31)
Denaturing agents (urea, acrylamide) protect enzymes against irreversible thermoinactivation: A study with native and immobilized α‐chymotrypsin and trypsin (1975) (31)
Thermodynamic analysis of solvent effect on substrate specificity of lyophilized enzymes suspended in organic media. (1997) (30)
Non-Aqueous Suspensions of Antibodies are Much Less Viscous Than Equally Concentrated Aqueous Solutions (2013) (29)
Protein refolding in predominantly organic media markedly enhanced by common salts. (1999) (29)
Enzymatic mechanochemistry: a new approach to studying the mechanism of enzyme action. (1976) (29)
Chemoenzymic synthesis of optically active (meth)acrylic polymers (1991) (29)
Enhancement of plasmid DNA immunogenicity with linear polyethylenimine (2012) (29)
Chemoselectivity of Enzymes in Anhydrous Media is Strongly Solvent Dependent (1993) (28)
Kinetic isotope effect investigation of enzyme mechanisms in organic solvents (1990) (27)
Detergent-enabled transport of proteins and nucleic acids through hydrophobic solvents. (1994) (26)
On structural damage incurred by bacteria upon exposure to hydrophobic polycationic coatings (2011) (26)
The oxidation of chiral alcohols catalyzed by catalase in organic solvents. (1995) (26)
Resolution of Racemic Mixtures via Lipase Catalysis in Organic Solvents. (1986) (25)
Light‐initiated enzymic activity caused by photostereoisomerization of cis‐4‐nitrocinnamoyl‐α‐chymotrypsin (1971) (25)
Attenuation of corneal myofibroblast development through nanoparticle-mediated soluble transforming growth factor-β type II receptor (sTGFβRII) gene transfer (2012) (25)
Calorimetric evidence for a native-like conformation of hen egg-white lysozyme dissolved in glycerol. (2000) (24)
Biotechnology of aroma compounds (1997) (24)
Stabilization of poliovirus against heat inactivation. (1989) (24)
Optimized protocol for the large scale production of HIV pseudovirions by transient transfection of HEK293T cells with linear fully deacylated polyethylenimine. (2007) (23)
Sequence optimization and designability of enzyme active sites. (2005) (22)
Molecular-modeling calculations of enzymatic enantioselectivity taking hydration into account. (1998) (22)
Cholinesterase‐catalyzed resolution of D,L‐carnitine (1984) (22)
The regeneration of coenzymes using immobilized hydrogenase (1980) (21)
Application of immobilized hydrogenase for the detritiation of water (1981) (21)
Biocidal packaging for pharmaceuticals, foods, and other perishables. (2013) (21)
The mechanochemistry of immobilized enzymes. How to steer a chemical process at the molecular level by a mechanical device. (1974) (21)
Enzyme memory. What is remembered and why? (1995) (21)
Moisture-Induced Aggregation of Lyophilized DNA and its Prevention (2006) (21)
Organic solvent binding to crystalline subtilisin1 in mostly aqueous media and in the neat solvents. (1998) (20)
Removing human immunodeficiency virus (HIV) from human blood using immobilized heparin (2012) (20)
Why do some immobilized N-alkylated polyethylenimines far surpass others in inactivating influenza viruses? (2015) (19)
Kinetic and Thermodynamic Aspects of Catalysis by Immobilised Enzymes (1975) (19)
Stereoselective oxidations and reductions catalyzed by nonredox proteins (2004) (19)
Light and ultrasonic regulation of α‐chymotrypsin catalytic activity Proflavin as a light‐ and sound‐sensitive competitive inhibitor (1974) (19)
Improving lipase enantioselectivity in organic solvents by forming substrate salts with chiral agents. (2000) (18)
Decreasing Herpes Simplex Viral Infectivity in Solution by Surface-Immobilized and Suspended N,N-Dodecyl,methyl-polyethylenimine (2012) (18)
Enzymatic Reactions in Liquid and Solid Paraffins: Application for Enzyme–Based Temperature Abuse Sensors (1986) (18)
Enzymes in organic solvents. (1989) (18)
Reducing infectivity of HIV upon exposure to surfaces coated with N,N-dodecyl, methyl-polyethylenimine. (2013) (18)
Inactivation of Bacteria by Electric Current in the Presence of Carbon Nanotubes Embedded Within a Polymeric Membrane (2014) (18)
Binding of hydrophobic hydroxamic acids enhances peroxidase's stereoselectivity in nonaqueous sulfoxidations. (2002) (17)
Answering the question: 'why did biocatalysis in organic media not take off in the 1930s?'. (2000) (17)
Drastically lowering the titer of waterborne bacteriophage PRD1 by exposure to immobilized hydrophobic polycations (2004) (17)
Mechanisms of Irreversible Thermoinactivation of Enzymes (1984) (17)
Asymmetric thiosulfinations catalyzed by bovine serum albumin and horseradish peroxidase (2003) (17)
Preparative separation of α‐ and β‐naphthols catalyzed by immobilized sulfatase (1983) (16)
Remarkable positional (regio)specificity of xanthine oxidase and some dehydrogenases in the reactions with substituted benzaldehydes. (1983) (15)
On the Relationship Between Enzymatic Enantioselectivity in Organic Solvents and Enzyme Flexibility (2000) (15)
A Method to Investigate Non-Thermal Effects of Radio Frequency Radiation on Pharmaceuticals with Relevance to RFID Technology (2006) (15)
Microbiological Measurements by Immobilization of Cells within Small‐Volume Elements (1984) (15)
Heterogeneity of serum albumin samples with respect to solid-state aggregation via thiol-disulfide interchange : Implications for sustained release from polymers (1997) (15)
Chelating agents protect hydrogenase against oxygen inactivation. (1979) (15)
Thermal stabilities of membrane-bound, solubilized, and artificially immobilized hydrogenase from Chromatium vinosum. (1980) (15)
Insights into the Solvent Dependence of Chymotryptic Prochiral Selectivity (1998) (14)
On the role of Transition-State Substrate Desolvation in Enzymatic Enantioselectivity in Aqueous-Organic Mixtures (1998) (14)
Protein chromatography in neat organic solvents. (1992) (14)
Advances in Enzymes (1989) (13)
Radio frequency radiation causes no nonthermal damage in enzymes and living cells (2010) (13)
Polycation-mediated delivery of siRNAs for prophylaxis and treatment of influenza virus infection (2005) (12)
Incorporation of D-Amino Acids into Peptides via Enzymatic Condensation in Organic Solvents. (1988) (12)
A new mechanochecmical method of enzyme immobilization (1977) (12)
Bioprocessing in nonaqueous media - critical needs and opportunities (1995) (11)
Mechanochemistry of immobilized enzymes: a new approach to studies in fundamental enzymology. I. Regulation by mechanical means of the catalytic properties of enzymes attached to polymer fibers. (1976) (11)
Aerosol-Assisted Plasma Deposition of Hydrophobic Polycations Makes Surfaces Highly Antimicrobial (2013) (11)
Geometric specificity of porcine liver carboxylesterase and its application for the production of cis-arylacrylic esters (1982) (11)
Preparative resolution of D,L‐threonine catalyzed by immobilized phosphatase (1985) (11)
Zanamivir Conjugated to Poly-L-Glutamine is Much More Active Against Influenza Viruses in Mice and Ferrets Than the Drug Itself (2013) (11)
Enzymatic Resolution of Racemic Amines (1990) (10)
Kinetics of bilirubin oxidase and modeling of an immobilized bilirubin oxidase reactor for bilirubin detoxification (1988) (10)
Geometric specificity of alcohol dehydrogenases and its potential for separation of trans and cis isomers of unsaturated aldehydes. (1982) (10)
Rapid Detection of E. coli Immobilized in Gel Microdroplets a (1987) (10)
Lysine and other diamines dramatically stabilize poliovirus against thermoinactivation. (1990) (10)
The effect of ultrasound as a new method of studying conformational transitions in enzyme active sites (1975) (10)
An antimicrobial polycationic sand filter for water disinfection. (2011) (10)
[12] Enzymatic production of optically active compounds in biphasic aqueous-organic systems (1987) (10)
Bulky Polar Additives That Greatly Reduce the Viscosity of Concentrated Solutions of Therapeutic Monoclonal Antibodies. (2017) (9)
Myoglobin-catalyzed epoxidation of styrene in organic solvents accelerated by bioimprinting (2000) (9)
Atrial natriuretic peptide attenuates LPS-induced lung vascular leak : role of PAK 1 (2010) (9)
Plasma-Treated Microplates with Enhanced Protein Recoveries and Minimized Extractables (2016) (8)
Bioprocess Design and Control (1993) (8)
Enzymatic formation of an isopeptide bond involving the ε-amino group of lysine (1988) (8)
Stereoselective Oligomerizations Catalyzed by Lipases in Organic Solvents. (1987) (7)
New Enzymes for Organic Synthesis (1997) (7)
Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation (2015) (7)
Peptide Synthesis Catalyzed by Lipases in Anhydrous Organic Solvents. (1987) (7)
Conjugation to polymeric chains of influenza drugs targeting M2 ion channels partially restores inhibition of drug-resistant mutants. (2013) (7)
Unexpectedly enhanced stereoselectivity of peroxidase-catalyzed sulfoxidation in branched alcohols. (2002) (7)
Conjugating drug candidates to polymeric chains does not necessarily enhance anti-influenza activity. (2012) (6)
The effect of electron carriers and other ligands on oxygen stability of clostridial hydrogenase. (1981) (6)
Downstream Processing Biosurfactants Carotenoids (2013) (6)
How a single-point mutation in horseradish peroxidase markedly enhances enantioselectivity. (2009) (6)
Stabilization of microbiol protease against autolysis using acylation with dicarboxylic acid anhydrides. (1982) (6)
[Mechanochemistry of catalytic systems. Regulation by mechanical means of the enzymatic activity of trypsin immobilized in polyacrylamide gel]. (1974) (6)
Mechanosensitive and Sound-Sensitive Enzymatic Systems as Chemical Amplifiers of Weak Signals (1977) (6)
Unusual Catalytic Properties of Usual Enzymes (1984) (6)
The Pharmaceutical Development of Insulin: Historical Perspectives and Future Directions (1997) (6)
Asymmetric sulfoxidations mediated by α‐chymotrypsin (2002) (6)
[Basis principles of enzyme stabilization. Increase in alpha-chymotrypsin thermostability by covalent addition to the complementary surface of a polymeric carrier]. (1976) (5)
The effect of mechanical stretching of the myosin rod component (fragment LMMMM S-2) on the ATPase activity of myosin. (1978) (5)
Alterations in the structure of proteins that cause their irreversible inactivation. (1992) (5)
Unconventional Catalytic Properties of Conventional Enzymes: Applications in Organic Chemistry (1983) (5)
Markedly lowering the viscosity of aqueous solutions of DNA by additives. (2015) (5)
Rapid immunodetection of Escherichia coli (2000) (5)
[Light-sensitive catalysts. 4-nitrocinnamoyl group as a chromophoric label of the active center of alpha-chymotrypsin]. (1972) (5)
An immobilized enzyme reactor for treatment of severe neonatal jaundice. (1985) (4)
Co-lyophilization with d-proline Greatly Enhances Peroxidase’s Stereoselectivity in a Non-aqueous Medium (2006) (4)
[Action of ultrasonics on alpha-chymotrypsin. A new approach to the study of conformational changes (transitions) in the active centers of enzymes]. (1974) (4)
Substrate Specificity of Enzymes in Organic Solvents vs. Water Is Reversed. (1986) (4)
Regioselective modification of Lysine's amino groups by proteases. (1991) (4)
Rapid And Substantial Gene Delivery Into Cornea In Vivo And In Vitro With Linearized Polyethyleneimine Nanoparticles (2011) (4)
Excipients activate peroxidases in specific but not in non-specific reactions in organic solvents (2001) (4)
Continuous 2HHO determination in H2O solution by a computer‐controlled mass spectrometer (1982) (4)
Mechanochemistry of immobilized enzymes: a new approach to studies in fundamental enzymology. II. Regulation of the rate of enzymic protein-protein interaction in polyacrylamide gel. (1976) (3)
Vancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid to treat bacterial endophthalmitis: Development, characterization, and ocular biocompatibility. (2020) (3)
Viscosity-Reducing Bulky-Salt Excipients Prevent Gelation of Protein, but Not Carbohydrate, Solutions (2017) (3)
ENZYMATIC SEPARATION OF CIS AND TRANS ISOMERS OF ALICYCLIC ALCOHOLS (1983) (3)
Structure-Activity Relationship for Hydrophobic Salts as Viscosity-Lowering Excipients for Concentrated Solutions of Monoclonal Antibodies (2012) (3)
Facile Enzymatic Preparation of Monoacylated Sugars in Pyridine. (1987) (3)
Enzymatic catalysis in organic solvents (1991) (3)
Approaches to stabilization of hydrogenase and nitrogenase against oxygen inactivation (1980) (2)
Enzymochemical Regioselective Oxidation of Steroids Without Oxidoreductases. (1988) (2)
CRYSTAL STRUCTURE OF SUBTILISIN CARLSBERG IN ANHYDROUS DIOXANE (1997) (2)
[Basic principles of enzyme stabilization. Increase in heat stability of alpha-chymotrypsin during immobilization on polymethacrylic acid gel]. (1975) (2)
COMPUTATIONAL AND EXPERIMENTAL EXAMINATION OF THE EFFECT OF INORGANIC SALTS ON CHYMOTRYPTIC ENANTIOSELECTIVITY IN WATER (1999) (2)
Application of immobilized hydrogenase to h2 storage in concentrated solutions of methyl viologen (1982) (2)
Protein engineering of yeast triose phosphate isomerase (1987) (2)
Epilogue: Prospects and challenges of biocatalysis in organic media (1996) (2)
BMP 7 Gene Transfer via Gold Nanoparticles into Stroma Inhibits Corneal Fibrosis In Vivo Citation (2013) (2)
Bioprocesses and Applied Enzymology (1990) (1)
Gold Nanoparticles: A Potent Vector for Non-Viral Corneal Endothelial Gene Therapy (2010) (1)
[Study of the penicillin amidase from E. coli. An ultrasonic method of studying the ph- and temperature-conformational transitions in the active center of the enzyme]. (1976) (1)
Protection of immobilized sulfhydryl groups against autooxidation by alterations in their microenvironment (1981) (1)
Bone Morphogenic Protein-7 (BMP7) Gene Therapy Inhibits Fibrosis by Up-regulating Smad1/5/8 in Rabbit Cornea in vivo (2012) (1)
Control ofoligomeric enzymethermostability byprotein engineering (1987) (1)
[Mechanochemistry of the myosin molecule]. (1977) (0)
N/P ratio in the PEI2-GNP-DNA complex affects transgene delivery in the human cornea in vitro (2010) (0)
Gold Nanoparticles as Potential Vectors for Gene Transfer in the Cornea (2009) (0)
Nanoparticle polyethylenimine-BMP7 Transfection Dose, Anti-fibrotic Efficacy and Toxicity for the Rabbit Cornea (2013) (0)
Asymmetric Oxidoreductions Catalyzed by Alcohol Dehydrogenase in Organic Solvents. (1987) (0)
Decreasing Herpes Simplex Viral Infectivity in Solution by Surface-Immobilized and Suspended N,N-Dodecyl,methyl-polyethylenimine (2012) (0)
Bioreactor Systems and Effects (1991) (0)
A new approach to preparative enzymatic synthesis. Reprinted from Biotechnology and Bioengineering, Vol. XIX, No. 9, Pages 1351-1361. (2000) (0)
Biotreatment, Downstream Processing and Modelling (1997) (0)
Removing human immunodeficiency virus (HIV) from human blood using immobilized heparin (2011) (0)
Asymmetric sulfoxidations mediated by alpha-chymotrypsin. (2002) (0)
Enzymatic production of optical isomers of 2-halopropionsaeuren. (1986) (0)
Engineering horseradish peroxidase with enhanced enantioselectivity (0)
Send-off for a new journal (1995) (0)
[39] Mechanochemistrry of immobilized enzymes: A new approach to studies in fundamental enzymology (1976) (0)
Book reviews (1981) (0)
Mechanistic Aspects of Enzymatic Catalysis in Anhydrous Organic Solvents (1993) (0)
DEVELOPMENT OF AN IMMOBILIZED ENZYME REACTOR FOR THE TREATMENT OF HYPERBILIRUBINEMIA (1984) (0)
SUBTILISIN STRUCTURE AND CATALYSIS IN NON-AQUEOUS MEDIA (2009) (0)
Covalent Attachment of N,N-Dodecyl,Methyl-Polyethylenimine to Boston Keratoprosthesis Materials Inhibits S. aureus Biofilm Formation Without Cytotoxicity or Corneal Cell Reactivity (2010) (0)
Preparative separation of alpha- and beta-naphthols catalyzed by immobilized sulfatase. (1983) (0)
Bioprocesses and Engineering (1989) (0)
(Biotechnol. Bioeng., 29: 648-651)Preparation of various glucose esters via lipase-catalyzed hydrolyses of glucose pentacetate (1987) (0)
Regioselective Acylation of Secondary Hydroxyl Groups in Sugars Catalyzed by Lipases in Organic Solvents. (1987) (0)
TRANS-CINNAMOYL-SUBTILISIN IN ANHYDROUS ACETONITRILE (1998) (0)
Introduction (1988) (0)
Compositions de vaccin stabilisees (1990) (0)
resorbable spinal fusion (1998) (0)
Inhibition of S. Aureus Biofilm Formation on Ocular-Related Prosthetic Materials by Use of an N-alkyl Polyethylenimine Polymer (2008) (0)
Addiction-prevention drug formulations (2005) (0)
Rational enhancement of enzyme performance in organic solvents. Final technical report, 1992--1996 (1996) (0)
Non-Aqueous Suspensions of Antibodies are Much Less Viscous Than Equally Concentrated Aqueous Solutions (2013) (0)
CRYSTAL STRUCTURE OF SUBTILISIN CARLSBERG IN 40% ACETONITRILE (1998) (0)
Formulations de prevention des abus (2005) (0)
Oxidative Reactions with Nonaqueous Enzymes (2001) (0)
Geometrically specific oxidation of β-arylacroleins catalyzed by xanthine oxidase: The preparative potential (2004) (0)
Polyethyleneimine (PEI) Nanoparticle-mediated Soluble TGFβRII Gene Transfer Prevents Corneal Fibrosis (2012) (0)
Zanamivir Conjugated to Poly-L-Glutamine is Much More Active Against Influenza Viruses in Mice and Ferrets Than the Drug Itself (2013) (0)
TRANS-CINNAMOYL-SUBTILISIN IN WATER (1998) (0)
Enzymatic production of chemicals in organic solvents (1987) (0)
A new approach to preparative enzymatic synthesis (0)
Chemoselective Enzymatic Monoacylation of Bifunctional Compounds. (1989) (0)
Formulations for drug abuse prevention (2005) (0)
Sensor Detects Overheating Of Perishable Material (1990) (0)
Protease-Catalyzed Regioselective Esterification of Sugars and Related Compounds in Anhydrous Dimethylformamide. (1988) (0)
Material for buffered resorbable internal fixation devices as well as the process for its preparation (1997) (0)
Enzyme Thermostability and its Enhancement by Genetic Engineering (1987) (0)
Simple Test For Organic Material In Gas (1989) (0)
Nitrogen To Phosphate Ratio In Nanoparticle-plasmid Transfection Reagent Modulates Gene Delivery And Toxicity In The Cornea (2011) (0)
Dry-Enzyme Test For Gaseous Chemicals (1990) (0)
Catalytic properties and thermal stability ofα-chymotrypsin in polyelectrolyte gels based on methacrylate (1975) (0)
Attaching Anti-ACE Antibody to Polyethylenimine Does Not Enhance Specificity of In Vivo PEI-Mediated Gene Delivery (2011) (0)
OXYGEN INACTIVATION AND STABILIZATION OF Azotobacter NITROGENASE (1982) (0)
Liquid pharmaceutical formulations for injection comprising yellow 5 or orange G and uses thereof (2014) (0)
SUBTILISIN CARLSBERG IN 20% DIOXANE (1998) (0)

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