Alexander Niculescu
American psychiatrist
Alexander Niculescu's AcademicInfluence.com Rankings
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Biology
Alexander Niculescu's Degrees
- Doctorate Medicine Carol Davila University of Medicine and Pharmacy
- PhD Neuroscience Purdue University
Why Is Alexander Niculescu Influential?
(Suggest an Edit or Addition)According to Wikipedia, Alexander Bogdan Niculescu, III is a Romanian born, San Diego, California, educated and trained scientist and physician. He is a Professor in the Department of Psychiatry at the Indiana University School of Medicine in Indianapolis, Indiana, Director of the Laboratory of Neurophenomics, and an Attending Psychiatrist and R&D Investigator at the Indianapolis VA Medical Center. Considered the inventor of Convergent Functional Genomics , he is a prominent figure in the field of personalized medicine in psychiatry. His early contributions to the psychiatric genetics field include identification of candidate genes, pathways and mechanisms for bipolar disorder using convergent studies In particular, his work and that of his collaborators has focused attention on circadian clock genes as core components of mood regulation Since these contributions, his research program has expanded to include similar work on schizophrenia alcoholism and stress disorders leading to the identification of panels of DNA and RNA markers for disease risk prediction and severity of illness. Niculescu pioneered early on the view that psychiatric disorders are genetically complex, heterogeneous, and overlapping, requiring gene level integration of data followed by pathway analyses. The cumulative combinatorics of common variants and environment model he described for bipolar and other complex disorders based on empirical data, is being increasingly supported by evidence from other groups working on psychiatric and non-psychiatric disorders. More recently, he has proposed a comprehensive unifying model for conceptualizing how the mind works. His most recent work has focused on understanding and developing genomic and clinical risk predictors for suicide, a preventable tragedy and increasing public health problem.
Alexander Niculescu's Published Works
Published Works
- Effects of p21Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication (1998) (757)
- Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction (2012) (375)
- Candidate genes, pathways and mechanisms for bipolar (manic–depressive) and related disorders: an expanded convergent functional genomics approach (2004) (216)
- Convergent functional genomics of genome‐wide association data for bipolar disorder: Comprehensive identification of candidate genes, pathways and mechanisms (2009) (207)
- Oxidative Mechanisms and Tardive Dyskinesia (2003) (206)
- Erratum: Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication (Molecular and Cellular Biology 18:1 (629)) (1998) (197)
- Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. (2000) (195)
- Discovery and validation of blood biomarkers for suicidality (2013) (167)
- Identification of blood biomarkers for psychosis using convergent functional genomics (2011) (163)
- Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach (2015) (138)
- Identifying blood biomarkers for mood disorders using convergent functional genomics (2009) (137)
- Towards understanding the schizophrenia code: An expanded convergent functional genomics approach (2007) (132)
- Evidence for genetic association of RORB with bipolar disorder (2009) (110)
- Phenomic, Convergent Functional Genomic, and biomarker studies in a stress‐reactive genetic animal model of bipolar disorder and co‐morbid alcoholism (2008) (103)
- Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial (2017) (101)
- Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach (2007) (93)
- Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms (2011) (86)
- Identifying blood biomarkers for mood disorders using convergent functional genomics (2009) (84)
- Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment (2016) (80)
- Genetic risk prediction and neurobiological understanding of alcoholism (2014) (78)
- Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions (2015) (74)
- Handwriting movement kinematics for quantifying extrapyramidal side effects in patients treated with atypical antipsychotics (2010) (72)
- Precision medicine for suicidality: from universality to subtypes and personalization (2017) (69)
- Coming to grips with complex disorders: Genetic risk prediction in bipolar disorder using panels of genes identified through convergent functional genomics (2010) (68)
- Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality (2015) (66)
- Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder (2008) (57)
- Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs (2019) (54)
- Handwriting movement analyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone. (2009) (52)
- MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties (2020) (50)
- Convergent Functional Genomics of bipolar disorder: From animal model pharmacogenomics to human genetics and biomarkers (2007) (50)
- Convergent Functional Genomics: what we have learned and can learn about genes, pathways, and mechanisms (2010) (48)
- Effects of p21Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication (1998) (47)
- PhenoChipping of psychotic disorders: A novel approach for deconstructing and quantitating psychiatric phenotypes (2006) (45)
- Convergent functional genomics: a Bayesian candidate gene identification approach for complex disorders. (2005) (44)
- Convergent functional genomic studies of omega-3 fatty acids in stress reactivity, bipolar disorder and alcoholism (2011) (42)
- Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs (2019) (41)
- Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs (2019) (39)
- Striatopallidal regulation of affect in bipolar disorder. (2006) (38)
- Comprehensive gene- and pathway-based analysis of depressive symptoms in older adults. (2015) (34)
- Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs (2021) (32)
- Convergent functional genomics: application to bipolar disorder (2001) (27)
- The P‐value illusion: How to improve (psychiatric) genetic studies (2010) (25)
- Convergent functional genomics of psychiatric disorders (2013) (22)
- Mood, stress and longevity: convergence on ANK3 (2016) (22)
- Polypharmacy in oligopopulations: what psychiatric genetics can teach biological psychiatry (2006) (19)
- Mindscape: a convergent perspective on life, mind, consciousness and happiness. (2010) (19)
- Finding Genes for Bipolar Disorder in the Functional Genomics Era: From Convergent Functional Genomics to Phenomics and Back (2002) (18)
- Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response (2015) (18)
- Genomic studies of mood disorders - the brain as a muscle? (2005) (15)
- Convergent integration of animal model and human studies of bipolar disorder (manic-depressive illness). (2010) (12)
- Erratum: Identifying blood biomarkers for mood disorders using convergent functional genomics (Molecular Psychiatry (2009) 14 (156-174) DOI: 10.1038/mp.2008.11) (2009) (11)
- Characteristics of Bipolar I patients grouped by externalizing disorders. (2015) (10)
- Assessing Risk of Future Suicidality in Emergency Department Patients (2018) (9)
- Toward Early, Personalized, Rational Polypharmacy In Psychiatry: A Tri‐Dimensional Approach (2010) (8)
- Genetics of Psychiatric Disorders (2008) (8)
- Handwriting Movement Kinematics for Quantifying EPS in Patients Treated with Atypical Antipsychotics (2010) (7)
- Dissecting Suicidality Using a Combined Genomic and Clinical Approach (2017) (6)
- The human genome: genetic testing and animal models. (2001) (6)
- Schizophrenia: from genetics to biology to predictive medicine. (2014) (5)
- Prophylactic antidepressant treatment before patients are admitted (2000) (5)
- Convergence of recent GWAS data for suicidality with previous blood biomarkers: independent reproducibility using independent methodologies in independent cohorts (2019) (5)
- Precision medicine in psychiatry: biomarkers to the forefront (2021) (3)
- DISCovery in psychiatric genetics (2014) (2)
- A brief proposal for improving clinical trials (2016) (1)
- Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. (2023) (1)
- Differential cell cycle arrest and apoptosis following inducffile expression of the cyclbst dependent kinase inhibitor p21 CIP1 in human cells (1996) (1)
- Convergent functional genomics of stem cell-derived cells (2013) (1)
- The will to live, suicide, and euthanasia. (2000) (1)
- Improving the prospective prediction of a near-term suicide attempt in veterans at risk for suicide, using a go/no-go task. (2022) (1)
- Research report Striatopallidal regulation of affect in bipolar disorder (2006) (0)
- 356. Precision Medicine for Suicidality: From Universality to Subtypes and Individualization (2017) (0)
- BLOOD BIOMARKERS FOR MEMORY: TOWARDS EARLY DETECTION OF RISK FOR ALZHEIMER DISEASE, PHARMACOGENOMICS, AND REPURPOSED DRUGS (2019) (0)
- S78. Towards Precision Medicine for Mood Disorders: New Diagnostics and Therapeutics for Depression and Mania (2019) (0)
- A convergent functional genomics approach identifies GRK3 as a candidate gene for bipolar disordr on 22q (2000) (0)
- 169 – Heterogeneity, overlap and interdependence of psychiatric disorders (2008) (0)
- Correction: Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality (2016) (0)
- S.15.01 Convergent functional genomics: an introduction (2011) (0)
- Polyphenic risk score shows robust predictive ability for long-term future suicidality (2022) (0)
- 471. Precision Medicine for Psychotic Disorders: Objective Assessment, Risk Prediction, Pharmacogenomics, and Repositioned Drugs (2023) (0)
- M7 TOWARDS PRECISION MEDICINE FOR MOOD DISORDERS: OBJECTIVE ASSESSMENT AND TARGETED THERAPEUTICS FOR DEPRESSION AND MANIA (2019) (0)
- Gene expression studies in psychiatric disorders (2012) (0)
- psychosis: a convergent functional genomics approach Identifying a series of candidate genes for mania and (2005) (0)
- Life and Mind (2017) (0)
- SA66 PRECISION MEDICINE FOR SUICIDALITY: FROM UNIVERSALITY TO SUBTYPES AND PERSONALIZATION (2019) (0)
- Identifying candidate genes for mania and psychosis using a convergent functional genomics approach (2000) (0)
- Temporal effects on death by suicide: empirical evidence and possible molecular correlates (2023) (0)
- Procede destine au diagnostic et au traitement de troubles mentaux (2001) (0)
- Molecular and Cellular Biology Research in Psychiatry (2002) (0)
- Erratum: Prophylactic antidepressant treatment before patients are admitted (The Lancet (2000) 29 January (406)) (2000) (0)
- S211. Towards Precision Medicine for Psychosis: Biomarkers for Hallucinations and Delusions (2018) (0)
- O45. Blood Biomarkers for Possible Early Detection of Risk for Alzheimer Disease (AD) (2019) (0)
- Colloquium C16: Gene Profiling in Disease (2003) (0)
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What Schools Are Affiliated With Alexander Niculescu?
Alexander Niculescu is affiliated with the following schools: