Alexandra Newton
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Computer Science
Alexandra Newton's Degrees
- Masters Computer Science Stanford University
- Bachelors Computer Science University of California, Berkeley
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Why Is Alexandra Newton Influential?
(Suggest an Edit or Addition)According to Wikipedia, Alexandra C. Newton is a Canadian and American biochemist. She is a Distinguished Professor of pharmacology at the University of California, San Diego. Newton runs a multidisciplinary Protein kinase C and Cell signaling biochemistry and cell biology research group in the School of Medicine, investigating molecular mechanisms of signal transduction in the Phospholipase C and Phosphoinositide 3-kinase signaling pathways. She has been continuously funded by the US National Institutes of Health since 1988.
Alexandra Newton's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells (2002) (2177)
- Protein Kinase C: Structure, Function, and Regulation (*) (1995) (1679)
- Regulation of protein kinase C. (1997) (988)
- Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. (2001) (964)
- PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. (2005) (879)
- Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. (2003) (830)
- Protein kinase C isozymes and the regulation of diverse cell responses. (2000) (732)
- Regulation of protein kinase C ζ by PI 3-kinase and PDK-1 (1998) (621)
- Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site* (2000) (571)
- PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. (2007) (566)
- A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C (2003) (540)
- The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C (2008) (518)
- Protein kinase C: poised to signal. (2010) (491)
- Protein kinase C is regulated in vivo by three functionally distinct phosphorylations (1995) (469)
- Cellular Signaling Pivoting around PDK-1 (2000) (450)
- Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) (1998) (397)
- Taxonomy and function of C1 protein kinase C homology domains (1997) (360)
- Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor (2015) (278)
- Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules. (1998) (268)
- p21-activated Kinase (PAK1) Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Kinase-1 (PDK1)* (2000) (242)
- Mechanism of Interaction of Protein Kinase C with Phorbol Esters (1995) (226)
- Specificity and Stability in Topology of Protein Networks (225)
- Spatio-temporal Dynamics of Protein Kinase B/Akt Signaling Revealed by a Genetically Encoded Fluorescent Reporter*♦ (2005) (217)
- The Phosphatase PHLPP Controls the Cellular Levels of Protein Kinase C* (2008) (203)
- PHLiPPing the switch on Akt and protein kinase C signaling (2008) (186)
- Protein kinase C pharmacology: refining the toolbox. (2013) (185)
- Regulation of protein kinase (1997) (181)
- Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol. (1992) (179)
- Targeting Protein Kinase C Activity Reporter to Discrete Intracellular Regions Reveals Spatiotemporal Differences in Agonist-dependent Signaling* (2006) (179)
- Protein Kinase C: Seeing two domains (1995) (177)
- Protein kinase C: perfectly balanced (2018) (170)
- In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation. (1994) (164)
- Regulation of novel protein kinase C ε by phosphorylation (2002) (162)
- Interaction of proteins with lipid headgroups: lessons from protein kinase C. (1993) (160)
- A Single Residue in the C1 Domain Sensitizes Novel Protein Kinase C Isoforms to Cellular Diacylglycerol Production* (2007) (159)
- Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. (2011) (156)
- The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation (1999) (153)
- The Turn Motif Is a Phosphorylation Switch That Regulates the Binding of Hsp70 to Protein Kinase C* (2002) (151)
- Phosphorylation at Conserved Carboxyl-terminal Hydrophobic Motif Regulates the Catalytic and Regulatory Domains of Protein Kinase C* (1997) (144)
- Carboxyl-terminal Phosphorylation Regulates the Function and Subcellular Localization of Protein Kinase C βII* (1999) (138)
- Intrapeptide regulation of protein kinase C. (1994) (138)
- Requirement for negative charge on "activation loop" of protein kinase C. (1994) (138)
- The C1 and C2 domains of protein kinase C are independent membrane targeting modules, with specificity for phosphatidylserine conferred by the C1 domain. (2000) (134)
- AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. (2008) (132)
- The life and death of protein kinase C. (2008) (129)
- The Phosphoinositide-dependent Kinase, PDK-1, Phosphorylates Conventional Protein Kinase C Isozymes by a Mechanism That Is Independent of Phosphoinositide 3-Kinase* (2001) (126)
- Turning off AKT: PHLPP as a drug target. (2014) (126)
- Spinal Phosphinositide 3-Kinase–Akt–Mammalian Target of Rapamycin Signaling Cascades in Inflammation-Induced Hyperalgesia (2011) (123)
- Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion (2000) (122)
- Increased Membrane Affinity of the C1 Domain of Protein Kinase Cδ Compensates for the Lack of Involvement of Its C2 Domain in Membrane Recruitment* (2006) (122)
- Interaction with AKAP79 modifies the cellular pharmacology of PKC. (2010) (116)
- The Chaperones Hsp90 and Cdc37 Mediate the Maturation and Stabilization of Protein Kinase C through a Conserved PXXP Motif in the C-terminal Tail*♦ (2009) (113)
- Phosphatidyl-L-serine is necessary for protein kinase C's high-affinity interaction with diacylglycerol-containing membranes. (1994) (113)
- Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C. (1987) (112)
- The Carboxyl Terminus of Protein Kinase C Provides a Switch to Regulate Its Interaction with the Phosphoinositide-dependent Kinase, PDK-1* (2001) (111)
- Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. (2014) (108)
- Membrane binding kinetics of protein kinase C betaII mediated by the C2 domain. (2001) (106)
- Sphingosine Is a Novel Activator of 3-Phosphoinositide-dependent Kinase 1* (2000) (106)
- Dual Role of Pseudosubstrate in the Coordinated Regulation of Protein Kinase C by Phosphorylation and Diacylglycerol* (2000) (105)
- Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation. (1992) (105)
- Centrosomal Anchoring of Protein Kinase C βII by Pericentrin Controls Microtubule Organization, Spindle Function, and Cytokinesis* (2004) (103)
- Isozyme-specific inhibition of protein kinase C by RNA aptamers. (1994) (103)
- PHLPP-1 Negatively Regulates Akt Activity and Survival in the Heart (2010) (103)
- Calcium-dependent Regulation of Protein Kinase D Revealed by a Genetically Encoded Kinase Activity Reporter* (2007) (103)
- Second Messengers. (2016) (102)
- Suppression of survival signalling pathways by the phosphatase PHLPP (2013) (97)
- Lipid activation of protein kinases This work was supported in part by National Institutes of Health GM43154. Published, JLR Papers in Press, November 24, 2008. (2009) (94)
- Involvement of protein kinase C in the phosphorylation of rhodopsin. (1991) (91)
- High cooperativity, specificity, and multiplicity in the protein kinase C-lipid interaction. (1989) (90)
- Spatiotemporal dynamics of lipid signaling: Protein kinase C as a paradigm (2008) (89)
- Rhodopsin is the major in situ substrate of protein kinase C in rod outer segments of photoreceptors. (1993) (88)
- Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction. (1999) (86)
- Regulation of novel protein kinase C epsilon by phosphorylation. (2002) (86)
- A Ras activation pathway dependent on Syk phosphorylation of protein kinase C (2003) (84)
- Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding. (1992) (81)
- Ca2+ Differentially Regulates Conventional Protein Kinase Cs’ Membrane Interaction and Activation* (1997) (74)
- Reversing The Paradigm: Protein Kinase C As A Tumor Suppressor (2016) (73)
- Apical-basal polarity inhibits Epithelial-Mesenchymal Transition and tumour metastasis via PAR complex-mediated SNAI1 degradation (2019) (72)
- Amplitude Control of Protein Kinase C by RINCK, a Novel E3 Ubiquitin Ligase* (2007) (71)
- Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase (PHLPP): A New Player in Cell Signaling* (2011) (71)
- Discovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening (2010) (70)
- Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease (2016) (70)
- Protein kinase C: Ports of anchor in the cell (1996) (69)
- PHLPPing through history: a decade in the life of PHLPP phosphatases. (2016) (68)
- Regulation of protein kinase C betaII by its C2 domain. (1997) (67)
- Protein kinase C as a tumor suppressor. (2017) (66)
- Cutting Edge: PHLPP Regulates the Development, Function, and Molecular Signaling Pathways of Regulatory T Cells (2011) (65)
- Protein kinase C autophosphorylates by an intrapeptide reaction. (1987) (63)
- Diacylglycerol's affair with protein kinase C turns 25. (2004) (61)
- Inhibition of the insulin receptor tyrosine kinase by sphingosine. (1991) (60)
- PKA, PKC, and AKAP localization in and around the neuromuscular junction (2001) (58)
- Protected‐Site Phosphorylation of Protein Kinase C in Hippocampal Long‐Term Potentiation (1998) (57)
- Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C. (2003) (56)
- Protein Kinase Cα Promotes Cell Migration through a PDZ-Dependent Interaction with its Novel Substrate Discs Large Homolog 1 (DLG1)* (2011) (55)
- Phosphatidylserine affects specificity of protein kinase C substrate phosphorylation and autophosphorylation. (1990) (55)
- Cellular Pharmacology of Protein Kinase Mζ (PKMζ) Contrasts with Its in Vitro Profile (2012) (53)
- Pathway Illuminated: Visualizing Protein Kinase C Signaling (2003) (53)
- Calcium-independent binding to interfacial phorbol esters causes protein kinase C to associate with membranes in the absence of acidic lipids. (1996) (53)
- Intramolecular conformational changes optimize protein kinase C signaling. (2014) (52)
- Tuning the signalling output of protein kinase C. (2014) (49)
- Conventional protein kinase C in the brain: 40 years later (2017) (49)
- Protein Kinase C δ-specific Activity Reporter Reveals Agonist-evoked Nuclear Activity Controlled by Src Family of Kinases*♦ (2010) (47)
- Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)* (2011) (46)
- Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock (2010) (46)
- Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors (2015) (45)
- Spatiotemporally Distinct Protein Kinase D Activation in Adult Cardiomyocytes in Response to Phenylephrine and Endothelin* (2011) (45)
- Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. (2015) (45)
- Peptidyl-prolyl Isomerase Pin1 Controls Down-regulation of Conventional Protein Kinase C Isozymes* (2012) (45)
- The Protein Scaffold NHERF-1 Controls the Amplitude and Duration of Localized Protein Kinase D Activity* (2009) (44)
- The C 1 and C 2 Domains of Protein Kinase C Are Independent Membrane Targeting Modules , with Specificity for Phosphatidylserine Conferred by the C 1 Domain † (2000) (43)
- KinView: a visual comparative sequence analysis tool for integrated kinome research. (2016) (42)
- Lipid structure and not membrane structure is the major determinant in the regulation of protein kinase C by phosphatidylserine. (1998) (42)
- Protein kinase C mechanisms that contribute to cardiac remodelling. (2016) (41)
- Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity* (2016) (41)
- Active Site Inhibitors Protect Protein Kinase C from Dephosphorylation and Stabilize Its Mature Form* (2011) (40)
- Common Polymorphism in the Phosphatase PHLPP2 Results in Reduced Regulation of Akt and Protein Kinase C* (2009) (40)
- Mechanism of the apparent cooperativity in the interaction of protein kinase C with phosphatidylserine. (1998) (39)
- Mislocalization of the E3 Ligase, β-Transducin Repeat-containing Protein 1 (β-TrCP1), in Glioblastoma Uncouples Negative Feedback between the Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase 1 (PHLPP1) and Akt* (2011) (39)
- Protein Kinase Cδ-mediated Phosphorylation of Connexin43 Gap Junction Channels Causes Movement within Gap Junctions followed by Vesicle Internalization and Protein Degradation* (2014) (38)
- Calcium Transduces Plasma Membrane Receptor Signals to Produce Diacylglycerol at Golgi Membranes* (2010) (37)
- The Adaptor Protein Grb14 Regulates the Localization of 3-Phosphoinositide-dependent Kinase-1* (2004) (37)
- Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation* (2015) (37)
- Invariant Leu Preceding Turn Motif Phosphorylation Site Controls the Interaction of Protein Kinase C with Hsp70* (2006) (37)
- Disruption of the Interface between the Pleckstrin Homology (PH) and Kinase Domains of Akt Protein Is Sufficient for Hydrophobic Motif Site Phosphorylation in the Absence of mTORC2* (2011) (36)
- Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival (2016) (36)
- Spatiotemporal Dynamics of Phosphorylation in Lipid Second Messenger Signaling* (2013) (36)
- mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif (2021) (36)
- Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions. (2003) (33)
- Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer. (2019) (33)
- Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. (2016) (32)
- Protein Scaffolds Control Localized Protein Kinase Cζ Activity* (2016) (32)
- A Putative Phosphatidylserine Binding Motif Is Not Involved in the Lipid Regulation of Protein Kinase C* (1997) (31)
- Kinetic Analysis of the Interaction of the C1 Domain of Protein Kinase C with Lipid Membranes by Stopped-flow Spectroscopy* (2008) (31)
- Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter (2019) (30)
- Kinetics and Localization of the Phosphorylation of Rhodopsin by Protein Kinase C (*) (1995) (30)
- Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions (2001) (30)
- Protein kinase Cα gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation (2018) (29)
- Identification of Protein Kinase C Phosphorylation Sites on Bovine Rhodopsin* (1997) (27)
- Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output (2014) (27)
- Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62* (2015) (26)
- The ins and outs of protein kinase C. (2003) (26)
- Electrostatic and Hydrophobic Interactions Differentially Tune Membrane Binding Kinetics of the C2 Domain of Protein Kinase Cα* (2013) (26)
- Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity (2018) (26)
- The PHLPP2 phosphatase is a druggable driver of prostate cancer progression (2019) (24)
- Does protein kinase C play a role in rhodopsin desensitization? (1993) (24)
- Characterization of Protein Kinase C in Photoreceptor Outer Segments (1997) (22)
- Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources (2018) (21)
- Biochemical Characterization of the Phosphatase Domain of the Tumor Suppressor PH Domain Leucine-Rich Repeat Protein Phosphatase (2014) (21)
- Contribution of Protein Kinase C to the Phosphorylation of Rhodopsin in Intact Retinas* (1997) (21)
- Intermembrane protein transfer. Band 3, the erythrocyte anion transporter, transfers in native orientation from human red blood cells into the bilayer of phospholipid vesicles. (1986) (20)
- Transfer of band 3, the erythrocyte anion transporter, between phospholipid vesicles and cells. (1983) (19)
- Isozyme-specific Interaction of Protein Kinase Cδ with Mitochondria Dissected Using Live Cell Fluorescence Imaging* (2012) (18)
- Analyzing protein kinase C activation. (2002) (17)
- Spatiotemporal Dynamics of Kinase Signaling Visualized by Targeted Reporters (2009) (17)
- Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light. (2003) (16)
- Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus (2020) (16)
- PHLPP1 counter-regulates STAT1-mediated inflammatory signaling (2019) (16)
- Protein kinase C fusion proteins are paradoxically loss of function in cancer (2021) (14)
- Vesicle-to-cell protein transfer: insertion of band 3, the erythrocyte anion transporter, into lymphoid cells. (1988) (14)
- Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation. (2015) (14)
- Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cells. (2011) (13)
- PHLPPing the balance: restoration of protein kinase C in cancer. (2021) (13)
- Diacylglycerol directly stimulates the insulin receptor tyrosine kinase (1996) (13)
- Protein Kinase C Promotes Cell Migration through a PDZ-Dependent Interaction with its Novel Substrate Discs Large Homolog 1 ( DLG 1 ) * (2011) (12)
- PHLPP Regulates the Development, Function and Molecular Signaling Pathways of T Regulatory Cells (2010) (11)
- PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling. (2020) (11)
- Protein kinase C protocols (2003) (10)
- Efflux of dipicolinic acid from human erythrocytes, sealed membrane fragments, and band 3-liposome complexes: a fluorescence probe for the erythrocyte anion transporter. (1986) (10)
- Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment? (2021) (9)
- Shedding light on local kinase activation (2012) (9)
- Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids (2010) (9)
- Protein kinase C association with the retinal cytoskeleton and phosphorylation of vimentin. (1994) (9)
- Regulation of the Phosphorylation State of Rhodopsin by Dopamine* (1998) (8)
- Protein kinase C as a measure of transbilayer phosphatidylserine asymmetry. (1994) (8)
- Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes (2020) (8)
- Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation. (2012) (7)
- Lymphoma-vesicle interactions: vesicle adsorption, membrane fragmentation, and intermembrane protein transfer. (1988) (7)
- Protein kinase C: release from quarantine by mTORC2. (2022) (7)
- Gene Expression of the Neuropeptide‐Processing Enzyme Carboxypeptidase E in Rat Photoreceptor Cells (1993) (7)
- Measuring the binding of protein kinase C to sucrose-loaded vesicles. (2003) (7)
- Use of stopped-flow fluorescence spectroscopy to measure rapid membrane binding by protein kinase C. (2003) (6)
- mTOR Regulation of AGC Kinases: New Twist to an Old Tail (2021) (6)
- Preparation and Characterization of Protein Kinase C from Rod Outer Segments (1993) (5)
- Mislocalization of the E 3 Ligase ,-Transducin Repeat-containing Protein 1 (-TrCP 1 ) , in Glioblastoma Uncouples Negative Feedback between the Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase 1 ( PHLPP 1 ) and Akt * (2011) (5)
- Imaging kinase activity at protein scaffolds. (2014) (4)
- Two Sides of the Same Coin: Protein Kinase C γ in Cancer and Neurodegeneration (2022) (4)
- Tuning the Signaling Output of Protein Kinase C (2018) (4)
- Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model (2021) (3)
- Protein kinase C (2008) (3)
- Apical–basal polarity inhibits epithelial–mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation (2019) (3)
- PKCα Is Recruited to Staphylococcus aureus-Containing Phagosomes and Impairs Bacterial Replication by Inhibition of Autophagy (2021) (3)
- PDZ interactions between PHLPP phosphatases and the NHERF scaffold (2012) (2)
- Abstract 125: Protein kinase C loss-of-function mutations in cancer reveal role as tumor suppressor (2015) (2)
- Induced Fit and Wit: Celebrating the Life of Daniel E. Koshland, Jr. (1920 ‐ 2007) (2007) (2)
- Ca2+-dependent liquid-liquid phase separation underlies intracellular Ca2+ stores (2021) (2)
- Inhibition of the insulin receptor tyrosine kinase by phosphatidic acid (1996) (2)
- PHLPP: PH Domain Leucine-Rich Repeat Protein Phosphatase (2010) (1)
- Phosphatase Activity of the Fungal Adenylate Cyclase Cyr1, the Yeast Homologue of PHLPP (2016) (1)
- Protein Kinase Cγ Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing Autoinhibition (2021) (1)
- Abstract 2405: Identification of PHLPP as a tumour suppressor reveals the role of pathway feedback compensation in PTEN-mutant prostate cancer progression (2011) (1)
- Deletion of the PH-domain and Leucine Rich Repeat Protein Phosphatase 1 ( Phlpp 1 ) Increases Fibroblast Growth Factor ( Fgf ) 18 Expression and Protects Against Surgically-Induced Osteoarthritis (2015) (1)
- Pharmacology on Target. (2020) (1)
- The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch (2021) (1)
- Cellular Signaling: Pivoting Minireview around PDK-1 (2000) (1)
- Prevalence of inactivating protein kinase C mutations in human cancers (1055.2) (2014) (1)
- Shedding light on local kinase activation (2012) (1)
- Bacterial spore coat protein kinases: A new twist to an old story (2016) (1)
- Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition (2022) (1)
- Protein Kinase C Family (2004) (1)
- Ras/Raf/MEK/ERK signal attenuation by the PHLPP Phosphatases (2008) (1)
- Intramolecular C 2 Domain-Mediated Autoinhibition of Protein Kinase C b II Graphical Abstract Highlights (2015) (1)
- Tumor Suppressor Phosphatase PHLPP Regulates Gene Expression Through Suppression of Transcription Factor Activation (2016) (0)
- Development of FRET-based reporter for visualizing protein kinase C delta activity (2010) (0)
- Protein kinase C: release from quarantine by mTORC2 Biochemical Sciences (2022) (0)
- PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) (2011) (0)
- Abstract 3463: Mitotic regulation of the tumor suppressor phosphatase PHLPP1 (2017) (0)
- P Protein Kinase C ( Prkc ) (2017) (0)
- Phosphomimetic Constructs of Akt/PKB do not Mimic Activated Akt in Cells (2016) (0)
- p 62 is a molecular target for ZIP 1 Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p 62 (2015) (0)
- Akt Signaling is Differentially Terminated by the Phosphatase PHLPP and a New Isoform, PHLPP2 (2007) (0)
- mTORC2 Regulates the Maturation of Protein Kinase C by Folding and Phosphorylation (2018) (0)
- Faculty Opinions recommendation of Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory. (2003) (0)
- CDK1‐dependent Phosphorylation of the Tumor Suppressor Phosphatase, PHLPP1, Regulates the Mitotic PHLPP1 Interactome (2018) (0)
- P Protein Kinase C (2021) (0)
- Small molecule inhibitors of PHLPP determined by chemical and virtual screening (2010) (0)
- PHLPP Phosphatase Regulation of EGFR Expression (2010) (0)
- Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. (2023) (0)
- Protein kinases in tune (2019) (0)
- PHLPP phosphatases are master regulators of cellular receptor tyrosine kinase levels (802.19) (2014) (0)
- Protein Kinase C Fusions Reveal Another Mechanism for Loss of Protein Kinase C Function in Cancer (2020) (0)
- Involvement of protein kinase C{alpha} in invadopodia formation in Src-3T3 cells (2010) (0)
- Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration (2023) (0)
- Author response: PHLPP1 counter-regulates STAT1-mediated inflammatory signaling (2019) (0)
- Mechanisms of atypical protein kinase C activation in insulin signaling (767.9) (2014) (0)
- Recognition Motif of Protein Kinase C and Protein Phosphatase 2A (2020) (0)
- Genetic depletion of the phosphatase PHLPP1 upregulates receptor tyrosine kinase signaling (2012) (0)
- Divalent cation driven liquid‐liquid phase separation of disordered acidic proteins (2022) (0)
- Protein Kinase C Promotes Cell Migration through a PDZ-Dependent Interaction with its Novel Substrate Discs (2011) (0)
- A new molecular mechanism of evasion of apoptosis revealed by novel C‐kinase activity reporter (2020) (0)
- Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer (2023) (0)
- Cancer‐Associated Fusions of the Protein Kinase C Kinase Domain are Loss‐of‐Function (2018) (0)
- mTORC2 Facilitates the Maturation of Protein Kinase C by a Phosphorylation‐Independent Mechanism (2017) (0)
- Maturation of protein kinase C masks its C1 domains (2012) (0)
- Abstract 1837: The C1A Domain of PKC Confers Sensitivity to Down-Regulation (2023) (0)
- Modulation of PHLPP activity: screening for specific inhibitors (2009) (0)
- FBP1 is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness (2023) (0)
- CHAPTER 153 – Protein Kinase C: Relaying Signals from Lipid Hydrolysis to Protein Phosphorylation (2003) (0)
- Lymphoma-vesicle interactions: vesicle adsorption, membrane fragmentation, and intermembrane protein transfer [Erratum to document cited in CA109(3):19823m] (1988) (0)
- Abstract 4488: Tumor suppressor phosphatase PHLPP1 regulates transcription factor activity and gene expression in inflammation (2017) (0)
- Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources (2018) (0)
- The PHLPP 2 phosphatase is a druggable driver of prostate cancer progression (2019) (0)
- Spatiotemporal Analysis of the Role that Protein Kinase A Phosphorylation Plays In Gap Junction Assembly (2015) (0)
- Abstract 1377: PHLPP, a Novel Akt Phosphatase, Expressed and is Regulated in Cardiomyocytes (2006) (0)
- The tumor suppressor phosphatase PHLPP1 suppresses inflammatory signaling by regulating the phosphorylation state and activity of STAT1 (2018) (0)
- Amplified Protein Kinase C Signaling in Alzheimer's Disease (2020) (0)
- Pleiotropic effects of PHLPP on cell signaling (2008) (0)
- Protein Kinase C: Relaying Signals from Lipid Hydrolysis to Protein Phosphorylation (2003) (0)
- PHLiPPing the Switch in Lipid Second Messenger Signaling (2008) (0)
- Protein kinase C δ signaling at mitochondria revealed by live cell fluorescence imaging, chemical genetics, and biochemical studies (2010) (0)
- Tracking mTORC1 Activity in the Nucleus: Distinct Regulation Revealed by Locationspecific Inhibition of Akt (2020) (0)
- Impaired Autoinhibition of Protein Kinase Cγ in Spinocerebellar Ataxia Type 14 (2020) (0)
- Scaffolding of atypical protein kinase C to p62 is disrupted by the pseudosubstrate peptide ZIP (802.4) (2014) (0)
- PHLPP Signaling in Immune Cells. (2022) (0)
- Protein kinase C mutations in cancer (2013) (0)
- Cancer‐Associated Fusion Proteins Reveal Inhibitory Role of Protein Kinase C's Processing Phosphorylations (2016) (0)
- Fusion Gene TANC2‐PRKCA Reveals Another Mechanism for Loss of Protein Kinase C Function in Cancer (2019) (0)
- Discrepancies in purified and cellular PKMζ inhibition profiles invalidate its proposed role as a mediator of memory (2012) (0)
- Imaging kinase: connexin43 interactions using phosphorylation activity biosensors and phospho‐specific antibodies (802.2) (2014) (0)
- Structural and Dynamical Basis of Protein Kinase C Alpha Regulation by the C-Terminal Tail (2017) (0)
- Regulation of Akt/Protein Kinase B Signaling by a Novel Protein Phosphatase in Breast Cancer Cells (2008) (0)
- Involvement of protein kinase Cα in invadopodia formation in Src‐3T3 cells (2010) (0)
- A Subtle Amino Acid Change Impacts Kinase Function in Dramatically Distinct Ways (2018) (0)
- The Protein Phosphatase PHLPP1 Suppresses Insulin Signaling and Inflammation in Mouse Model (2018) (0)
- Imaging PKC activity at MAGUK protein scaffolds (2008) (0)
- PNAS Plus Significance Statements (2015) (0)
- Abstract 5270: Prevalence of inactivating protein kinase C mutations in human cancers (2014) (0)
- PKD inhibitor treatment results in increased PKD activation loop phosphorylation (1055.1) (2014) (0)
- Phlpp1 deletion increases Fgf18 expression and protects against surgically-induced osteoarthritis (2015) (0)
- Diacylglycerol production at the Golgi: regulation by Ca2+ (2010) (0)
- Kinases/Phosphatases | Protein Kinase C Family (2021) (0)
- Spatiotemporal dynamics of lipid second messenger signaling (2008) (0)
- Protein kinase C showcases allosteric control: activation of LRRK1 (2023) (0)
- Chapter 12 Cellular regulation of protein kinase C (2001) (0)
- Intramolecular C2‐Kinase Domain Interactions Autoinhibit Conventional Protein Kinase (2016) (0)
- The phosphatase PHLPP1 is a key regulator of insulin signaling in vivo (2008) (0)
- Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer’s disease (2016) (0)
- A genetically‐encoded reporter reveals novel regulation of protein kinase D by calcium (2006) (0)
- Spatio-Temporal Dissection of Protein Kinase C-Mediated Phosphorylation of the Gap Junction Protein Connexin43 (2012) (0)
- CDK1‐dependent Phosphorylation of the Tumor Suppressor Phosphatase, PHLPP1, Regulates the Mitotic PHLPP1 Interactome (2020) (0)
- Protein kinase C {delta} signaling at mitochondria revealed by live cell fluorescence imaging, chemical genetics, and biochemical studies (2010) (0)
- Autophosphorylation of Protein Kinase C Facilitates its Ubiquitination and Down‐regulation (2006) (0)
- Decision letter: PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins (2019) (0)
- Abstract 198: Endothelin-1 and Phenylephrine Activate Global Protein Kinase D Similarly in Adult Cardiac Myocytes, but Differ Greatly in Nuclear versus Sarcolemmal Targeting (2007) (0)
- Localized PKD activity at PDZ domain‐containing scaffolds (2008) (0)
- Imaging Oscillations of Protein Kinase C Activity in Cells (2012) (0)
- Autophosphorylation of Protein Kinase C facilitates its ubiquitination and downregulation (2006) (0)
- Novel PKC signaling in Alzheimer’s Disease (2022) (0)
- Biochemical characterization of the PP2C domain of PHLPP (2008) (0)
- My Favorite Enzyme (2008) (0)
- Visualization of protein kinase C activity in live cells in response to natural stimulation of endogenous receptors (2006) (0)
- Rare Alzheimer's Disease‐Associated Protein Kinase C Variant Displays Altered Pharmacological Profile in a Cellular Environment (2018) (0)
- Analysis of Cancer‐associated Mutations in the Novel PKC Theta (2022) (0)
- Measuring the interaction of protein kinase C with membranes: an introduction. (2003) (0)
- Abstract 1888: Protein kinase C beta II suppresses colorectal cancer by regulating IGF1 mediated cell survival (2016) (0)
- Atypical Protein Kinase C‐specific Activity Reporter Reveals Novel Activation Mechanism of Atypical Protein Kinase C by Sphingosine 1‐phosphate (2018) (0)
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