Alexandros Makriyannis
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Why Is Alexandros Makriyannis Influential?
(Suggest an Edit or Addition)According to Wikipedia, Alexandros Makriyannis is an American biochemist and professor of chemistry and chemical biology in the department of medicinal chemistry at Northeastern University in Boston, Massachusetts, where he directs the Center for Drug Discovery and holds the George Behrakis Chair of Pharmaceutical Biotechnology. His research has focused on the biochemical basis of the endocannabinoid system and on the development of synthetic cannabinoids.
Alexandros Makriyannis's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors (2005) (1434)
- Functional role of high-affinity anandamide transport, as revealed by selective inhibition. (1997) (810)
- CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. (2005) (518)
- Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS (2003) (462)
- Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. (1999) (429)
- Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. (2010) (420)
- Crystal Structure of the Human Cannabinoid Receptor CB1 (2016) (405)
- CB2 cannabinoid receptor-mediated peripheral antinociception (2001) (387)
- Agonist‐inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630 (1999) (386)
- Endocannabinoids control spasticity in a multiple sclerosis model (2001) (377)
- Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis (2001) (373)
- (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. (1994) (333)
- Crystal structures of agonist-bound human cannabinoid receptor CB1 (2017) (325)
- Functional CB1 cannabinoid receptors in human vascular endothelial cells. (2000) (318)
- A new antibiotic selectively kills Gram-negative pathogens (2019) (306)
- Structural determinants for recognition and translocation by the anandamide transporter. (1999) (267)
- 123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors. (1996) (256)
- Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity (2013) (250)
- Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2 Cannabinoid Receptors (2003) (229)
- Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. (2004) (220)
- CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? (2003) (204)
- Crystal Structure of the Human Cannabinoid Receptor CB2 (2019) (201)
- Selective activation of cannabinoid CB2 receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation (2003) (175)
- Dopaminergic Modulation of Effort-Related Choice Behavior as Assessed by a Progressive Ratio Chow Feeding Choice Task: Pharmacological Studies and the Role of Individual Differences (2012) (173)
- Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis (2009) (169)
- The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats (2003) (167)
- A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents (2010) (158)
- Structure and orientation of the pore-forming peptide, melittin, in lipid bilayers. (1994) (155)
- Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1–Dependent Withdrawal (2015) (152)
- Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors. (1997) (146)
- The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition (2008) (143)
- AM630, a competitive cannabinoid receptor antagonist. (1995) (142)
- Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. (1996) (141)
- Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures (2020) (140)
- The Novel Cannabinoid CB1 Receptor Neutral Antagonist AM4113 Suppresses Food Intake and Food-Reinforced Behavior but Does not Induce Signs of Nausea in Rats (2008) (138)
- AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis. (2006) (136)
- Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. (1997) (136)
- Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain? (2009) (136)
- Evidence that anandamide‐signaling regulates human sperm functions required for fertilization (2002) (136)
- Cannabinoid CB1 receptor inverse agonists and neutral antagonists: Effects on food intake, food-reinforced behavior and food aversions (2007) (133)
- Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. (1998) (132)
- Anandamide hydroxylation by brain lipoxygenase:metabolite structures and potencies at the cannabinoid receptor. (1995) (131)
- Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease (2003) (129)
- Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats (2007) (127)
- Imaging the Brain Marijuana Receptor: Development of a Radioligand that Binds to Cannabinoid CB1 Receptors In Vivo (1998) (123)
- Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma (2010) (122)
- Selective Activation of Cannabinoid CB2 Receptors Suppresses Hyperalgesia Evoked by Intradermal Capsaicin (2004) (121)
- Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis (2009) (117)
- Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. (2004) (117)
- Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase. (1999) (117)
- Dual Modulation of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Protects against Excitotoxicity (2005) (116)
- CB2 cannabinoid receptor mediation of antinociception. (2006) (111)
- Selective Activation of Cannabinoid CB2 Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats (2008) (110)
- Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors. (1998) (110)
- The Endogenous Cannabinoid Anandamide Produces δ-9-Tetrahydrocannabinol-Like Discriminative and Neurochemical Effects That Are Enhanced by Inhibition of Fatty Acid Amide Hydrolase but Not by Inhibition of Anandamide Transport (2007) (109)
- Large receptor reserve for cannabinoid actions in the central nervous system. (1999) (108)
- Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior (2008) (103)
- Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages (2017) (103)
- Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis (2007) (101)
- The endocannabinoid system as a target for alkamides from Echinacea angustifolia roots. (2005) (100)
- Cannabis sativa and Hemp (2016) (100)
- Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality. (2010) (100)
- The Cannabinoid Agonist WIN55,212-2 Suppresses Opioid-induced Emesis in Ferrets (2001) (98)
- Potentiation of anandamide hypotension by the transport inhibitor, AM404. (1997) (97)
- Cannabinoid Agonists but not Inhibitors of Endogenous Cannabinoid Transport or Metabolism Enhance the Reinforcing Efficacy of Heroin in Rats (2005) (96)
- Medicinal chemistry of cannabinoids (2015) (95)
- From cannabis to cannabinergics: new therapeutic opportunities. (2002) (94)
- Inhibition of pain responses by activation of CB(2) cannabinoid receptors. (2002) (91)
- (-)-7′-Isothiocyanato-11-hydroxy-1′,1′-dimethylheptylhexahydrocannabinol (AM841), a High-Affinity Electrophilic Ligand, Interacts Covalently with a Cysteine in Helix Six and Activates the CB1 Cannabinoid Receptor (2005) (90)
- Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation. (2008) (90)
- Intrathecal cannabilactone CB2R agonist, AM1710, controls pathological pain and restores basal cytokine levels (2012) (90)
- The molecular basis of cannabinoid activity. (1990) (89)
- Identification of a potent and highly efficacious, yet slowly desensitizing CB1 cannabinoid receptor agonist (2004) (89)
- CB2 cannabinoid receptor mediation of antinociception (2006) (89)
- Pharmacotherapeutic targeting of the endocannabinoid signaling system: Drugs for obesity and the metabolic syndrome (2008) (89)
- Endocannabinoid Enhancement Protects against Kainic Acid-Induced Seizures and Associated Brain Damage (2007) (88)
- Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. (2010) (87)
- (R)-Methanandamide and Δ9-THC as discriminative stimuli in rats: tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide (2001) (87)
- The VMAT-2 Inhibitor Tetrabenazine Affects Effort-Related Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs (2014) (86)
- Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial. (2019) (86)
- A neutral CB1 receptor antagonist reduces weight gain in rat. (2007) (86)
- N‐Acylethanolamine‐hydrolyzing acid amidase inhibition increases colon N‐palmitoylethanolamine levels and counteracts murine colitis (2014) (86)
- Latest advances in cannabinoid receptor agonists (2009) (85)
- A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome (2014) (85)
- The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats (2005) (85)
- CB1 cannabinoid receptor ligands. (2005) (83)
- Quantitative method for the profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS. (2007) (81)
- The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB2 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy (2012) (81)
- Cannabinoids Inhibit HIV-1 Gp120-Mediated Insults in Brain Microvascular Endothelial Cells1 (2008) (81)
- Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics. (1997) (79)
- Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices (1997) (78)
- Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: Comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142 (2010) (78)
- Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations. (1995) (78)
- Covalent inhibitors of human monoacylglycerol lipase: ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis. (2008) (76)
- Mutation Studies of Ser7.39 and Ser2.60 in the Human CB1 Cannabinoid Receptor: Evidence for a Serine-Induced Bend in CB1 Transmembrane Helix 7 (2007) (76)
- Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. (2007) (76)
- Design and synthesis of the CB1 selective cannabinoid antagonist AM281: A potential human SPECT ligand (1999) (76)
- Inhibition of intestinal motility by anandamide, an endogenous cannabinoid. (1997) (76)
- &Dgr;9-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice (2012) (73)
- Characterization of the L lambda phase in trehalose-stabilized dry membranes by solid-state NMR and X-ray diffraction. (1989) (72)
- Expression and Function of Cannabinoid Receptors CB1 and CB2 and Their Cognate Cannabinoid Ligands in Murine Embryonic Stem Cells (2007) (70)
- The cannabinoid CB2 receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis (2014) (70)
- The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior (2010) (69)
- Synthon-based ligand discovery in virtual libraries of over 11 billion compounds (2021) (68)
- Role of the NH2-terminal domain of angiotensin II (ANG II) and [Sar1]angiotensin II on conformation and activity. NMR evidence for aromatic ring clustering and peptide backbone folding compared with [des-1,2,3]angiotensin II. (1994) (68)
- The Conformation, Location, and Dynamic Properties of the Endocannabinoid Ligand Anandamide in a Membrane Bilayer* (2005) (67)
- Cannabinergic ligands. (2002) (66)
- The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine‐induced dopamine elevations in the nucleus accumbens shell in rats (2012) (66)
- Model Investigations for Vanadium-Protein Interactions. Synthetic, Structural, and Physical Studies of Vanadium(III) and Oxovanadium(IV/V) Complexes with Amidate Ligands. (1996) (66)
- Effects of a Selective Cannabinoid CB2 Agonist and Antagonist on Intravenous Nicotine Self Administration and Reinstatement of Nicotine Seeking (2012) (65)
- Crystal Structure of the Human Cannabinoid Receptor CB 1 (2017) (65)
- AM630 antagonism of cannabinoid-stimulated [35S]GTPγS binding in the mouse brain (1997) (65)
- Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis. (2009) (64)
- Natural cannabinoids: templates for drug discovery. (2005) (64)
- Cannabinoids Alleviate Experimentally Induced Intestinal Inflammation by Acting at Central and Peripheral Receptors (2014) (62)
- Comprehensive profiling of the human circulating endocannabinoid metabolome: clinical sampling and sample storage parameters (2008) (61)
- Molecular probes for the cannabinoid receptors. (2000) (61)
- Extrapyramidal effects of methanandamide, an analog of anandamide, the endogenous CB1 receptor ligand. (1996) (61)
- Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. (1998) (60)
- Inverse agonism of cannabinoid CB1 receptors potentiates LiCl‐induced nausea in the conditioned gaping model in rats (2010) (60)
- Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: Antinociception without central nervous system side-effects (2011) (59)
- Some effects of CB1 antagonists with inverse agonist and neutral biochemical properties (2008) (59)
- The Conformational Properties of the Highly Selective Cannabinoid Receptor Ligand CP-55,940 (*) (1996) (59)
- 3D-QSAR studies of arylpyrazole antagonists of cannabinoid receptor subtypes CB1 and CB2. A combined NMR and CoMFA approach. (2006) (59)
- Δ9-THC training dose as a determinant for (R)-methanandamide generalization in rats (1998) (59)
- Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamide. (1999) (58)
- Self-medication of a cannabinoid CB2 agonist in an animal model of neuropathic pain (2011) (58)
- Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress. (2015) (58)
- Prevention of Fibrosis Progression in CCl4-Treated Rats: Role of the Hepatic Endocannabinoid and Apelin Systems (2012) (58)
- Gαs signalling of the CB1 receptor and the influence of receptor number (2017) (57)
- Functional selectivity at G‐protein coupled receptors: Advancing cannabinoid receptors as drug targets (2017) (57)
- Blocking cannabinoid activation of FAK and ERK1/2 compromises synaptic integrity in hippocampus. (2005) (56)
- Inhibiting fatty acid amide hydrolase normalizes endotoxin‐induced enhanced gastrointestinal motility in mice (2012) (56)
- Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-beta. (2002) (56)
- Adamantyl cannabinoids: a novel class of cannabinergic ligands. (2005) (56)
- AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. (1997) (55)
- Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase – Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology (2012) (55)
- Targeting the endocannabinoid system in treating brain disorders (2006) (55)
- Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor. (2002) (54)
- AM630 is an inverse agonist at the human cannabinoid CB1 receptor. (1998) (54)
- Structure-activity relationships of anandamide, an endogenous cannabinoid ligand. (1999) (54)
- Unsaturated Side Chain β-11-Hydroxyhexahydrocannabinol Analogs (1996) (54)
- The CB1 Neutral Antagonist AM4113 Retains the Therapeutic Efficacy of the Inverse Agonist Rimonabant for Nicotine Dependence and Weight Loss with Better Psychiatric Tolerability (2016) (53)
- How lipophilic cannabinergic ligands reach their receptor sites. (2005) (52)
- Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374). (1999) (52)
- Effects of cannabinoids on prolactin and gonadotrophin secretion: involvement of changes in hypothalamic gamma-aminobutyric acid (GABA) inputs. (1998) (52)
- Role of the Endogenous Cannabinoid System in Nicotine Addiction: Novel Insights (2015) (51)
- Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia (2012) (51)
- Cannabinoid receptors as therapeutic targets. (2006) (51)
- Structural requirements for cannabinoid receptor probes. (2005) (50)
- 2012 Division of medicinal chemistry award address. Trekking the cannabinoid road: a personal perspective. (2014) (50)
- Endocannabinoid Signaling Regulates Sleep Stability (2016) (50)
- Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys (2016) (49)
- Deuterium NMR investigation of ether- and ester-linked phosphatidylcholine bilayers. (1985) (48)
- Cannabinergic aminoalkylindoles, including AM678=JWH018 found in ‘Spice’, examined using drug (&Dgr;9-tetrahydrocannabinol) discrimination for rats (2011) (48)
- Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s) (2015) (48)
- Endocannabinoid and Cannabinoid-Like Fatty Acid Amide Levels Correlate with Pain-Related Symptoms in Patients with IBS-D and IBS-C: A Pilot Study (2013) (48)
- The conformation of the cytoplasmic helix 8 of the CB1 cannabinoid receptor using NMR and circular dichroism. (2005) (48)
- The neutral cannabinoid CB1 receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat (2011) (48)
- A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing (1998) (47)
- PET studies in the primate brain and biodistribution in mice using (−)-5′-18 F-Δ 8-THC (1991) (47)
- Differential effects of CB1 neutral antagonists and inverse agonists on gastrointestinal motility in mice (2010) (46)
- Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery (2014) (46)
- Stereochemical selectivity of methanandamides for the CB1 and CB2 cannabinoid receptors and their metabolic stability. (2001) (46)
- (R)‐Methanandamide: A Chiral Novel Anandamide Possessing Higher Potency and Metabolic Stability. (1994) (46)
- The CB1 inverse agonist AM251, but not the CB1 antagonist AM4113, enhances retention of contextual fear conditioning in rats (2010) (46)
- Methoxy group conformations of phenyl methyl ethers in solution (1982) (45)
- A New Generation Fatty Acid Amide Hydrolase Inhibitor Protects Against Kainate-Induced Excitotoxicity (2011) (45)
- Amphipathic interactions of cannabinoids with membranes. A comparison between delta 8-THC and its O-methyl analog using differential scanning calorimetry, X-ray diffraction and solid state 2H-NMR. (1992) (44)
- Cannabinoid Discrimination and Antagonism by CB1 Neutral and Inverse Agonist Antagonists (2013) (43)
- Novel 1',1'-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist. (2010) (43)
- Antileishmanial ring-substituted ether phospholipids. (2003) (42)
- Novel and efficient one-step parallel synthesis of dibenzopyranones via Suzuki-Miyaura cross coupling. (2010) (41)
- High-performance liquid chromatographic determination of anandamide amidase activity in rat brain microsomes. (1996) (41)
- Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire (2013) (41)
- Study of the topography of cannabinoids in model membranes using X-ray diffraction. (1990) (40)
- Effects of the CB1R agonist WIN-55,212-2 and the CB1R antagonists SR-141716 and AM-1387: Open-field examination in rats (2006) (40)
- Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. (2003) (40)
- Azodicarboxylic acid esters as dealkylating agents. (1973) (40)
- Mapping the Structural Requirements in the CB1 Cannabinoid Receptor Transmembrane Helix II for Signal Transduction (2008) (39)
- Dual therapy targeting the endocannabinoid system prevents experimental diabetic nephropathy (2017) (39)
- Effects of the anesthetic steroid alphaxalone and its inactive delta 16-analog on the thermotropic properties of membrane bilayers. A model for membrane perturbation. (1995) (39)
- Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/inverse agonist AM 1387 (2006) (38)
- Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor. (2005) (38)
- The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats (2008) (38)
- Natural and synthetic endocannabinoids and their structure-activity relationships. (2000) (38)
- Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues. (1998) (38)
- The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats (2003) (37)
- Biochemical and Mass Spectrometric Characterization of Human N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition (2012) (37)
- C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. (2007) (37)
- Therapeutic opportunities through modulation of the endocannabinoid system (2005) (36)
- Mass spectrometry-based proteomics of human cannabinoid receptor 2: covalent cysteine 6.47(257)-ligand interaction affording megagonist receptor activation. (2011) (36)
- Purification and mass spectroscopic analysis of human CB1 cannabinoid receptor functionally expressed using the baculovirus system. (2005) (36)
- High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor. (2005) (36)
- Intrinsic effects of AM4113, a putative neutral CB1 receptor selective antagonist, on open-field behaviors in rats (2008) (36)
- Behavioral effects of the novel cannabinoid full agonist AM 411 (2005) (36)
- Analysis of Tolerance and Behavioral/Physical Dependence during Chronic CB1 Agonist Treatment: Effects of CB1 Agonists, Antagonists, and Noncannabinoid Drugs (2013) (35)
- Antagonism of discriminative stimulus effects of Δ9-THC and (R)-methanandamide in rats (2005) (35)
- (-)-11-Hydroxy-7'-isothiocyanato-1',1'-dimethylheptyl-delta 8-THC: a novel, high-affinity irreversible probe for the cannabinoid receptor in the brain. (1994) (35)
- Oral bioavailability of the novel cannabinoid CB1 antagonist AM6527: Effects on food-reinforced behavior and comparisons with AM4113 (2009) (35)
- Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells (2013) (34)
- Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification. (2008) (34)
- Novel 1′,1′-chain substituted Δ8-tetrahydrocannabinols (2002) (34)
- The orientation of (-)-delta 9-tetrahydrocannabinol in DPPC bilayers as determined from solid-state 2H-NMR. (1989) (34)
- Synthesis of functionalized cannabinoids. (2000) (33)
- The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing (2011) (33)
- In vitro determination of the efficacy of illicit synthetic cannabinoids at CB1 receptors (2019) (33)
- Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal (2018) (33)
- Cannabinoid-1 receptor neutral antagonist reduces binge-like alcohol consumption and alcohol-induced accumbal dopaminergic signaling (2018) (33)
- Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity (2019) (33)
- Geometric requirements for membrane perturbation and anesthetic activity. Conformational analysis of alphaxalone and delta 16-alphaxalone and 2H NMR studies on their interactions with model membranes. (1985) (33)
- hCB2 ligand-interaction landscape: cysteine residues critical to biarylpyrazole antagonist binding motif and receptor modulation. (2010) (33)
- Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: Drug-discovery strategies (2009) (33)
- Studies on the thermotropic effects of cannabinoids on phosphatidylcholine bilayers using differential scanning calorimetry and small angle X-ray diffraction. (1996) (32)
- AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking (2013) (32)
- In vivo imaging of the brain cannabinoid receptor. (2002) (32)
- Discriminative stimulus functions of methanandamide and ∆9-THC in rats: tests with aminoalkylindoles (WIN55,212-2 and AM678) and ethanol (2009) (32)
- Sulfonyl fluoride inhibitors of fatty acid amide hydrolase. (2012) (32)
- Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates (2016) (31)
- A novel electrophilic high affinity irreversible probe for the cannabinoid receptor. (1995) (31)
- The perturbation of model membranes by (-)-delta 9-tetrahydrocannabinol. Studies using solid-state 2H- and 13C-NMR. (1990) (31)
- Methamphetamine discrimination and in vivo microdialysis in squirrel monkeys (2004) (31)
- Studies on the interaction of anesthetic steroids with phosphatidylcholine using 2H and 13C solid state NMR. (1986) (31)
- Purification and mass spectroscopic analysis of human CB2 cannabinoid receptor expressed in the baculovirus system. (2004) (31)
- Pharmacological evaluation of halogenated Δ 8-THC analogs (1991) (30)
- 5'-Azido-delta 8-THC: a novel photoaffinity label for the cannabinoid receptor. (1992) (30)
- (R)-Methanandamide and delta9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A. (2003) (30)
- Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats (2016) (29)
- Pharmacological evaluation of iodo and nitro analogs of Δ 8-THC and Δ 9-THC (1993) (29)
- Mass spectrometric characterization of human N-acylethanolamine-hydrolyzing acid amidase. (2012) (29)
- Cannabinoid CB1 receptor neutral antagonist AM4113 inhibits heroin self-administration without depressive side effects in rats (2018) (29)
- Δ9‐THC training dose as a determinant for (R)‐methanandamide generalization in rats: a systematic replication (2000) (29)
- Novel adamantyl cannabinoids as CB1 receptor probes. (2013) (29)
- N-acylethanolamine-hydrolyzing acid amidase and fatty acid amide hydrolase inhibition differentially affect N-acylethanolamine levels and macrophage activation. (2017) (29)
- AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner (2015) (29)
- Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters. (2012) (28)
- Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. (2011) (28)
- Endogenous Cannabinoids Improve Myocardial Resistance to Arrhythmogenic Effects of Coronary Occlusion and Reperfusion: a Possible Mechanism (2002) (27)
- Ligand based structural studies of the CB1 cannabinoid receptor. (2002) (27)
- Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. (2007) (27)
- Conformational analysis of the prototype nonclassical cannabinoid CP-47,497, using 2D NMR and computer molecular modeling. (1994) (27)
- Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers. (2001) (27)
- The cannabinergic system as a target for anti-inflammatory therapies. (2006) (27)
- Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase (2018) (27)
- Functional CB 1 cannabinoid receptors in human vascular endothelial cells (27)
- Hydrogen-Deuterium Exchange Mass Spectrometry to Study Protein Complexes. (2018) (26)
- Common cannabimimetic pharmacophoric requirements between aminoalkyl indoles and classical cannabinoids. (1995) (26)
- Protection from Radiation-Induced Pulmonary Fibrosis by Peripheral Targeting of Cannabinoid Receptor-1. (2015) (26)
- Effects of delta-9-tetrahydrocannabinol and (R)-methanandamide on open-field behavior in rats. (1998) (26)
- Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R‐[125/131I]AM2233 (2006) (25)
- Diuretic Effects of Cannabinoids (2013) (25)
- Cannabis in Veterinary Medicine: Cannabinoid Therapies for Animals (2019) (25)
- Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors (2014) (25)
- Discriminative stimulus effects in rats of SR-141716 (rimonabant), a cannabinoid CB1 receptor antagonist (2004) (25)
- Effects of cannabinoid receptor antagonists on maintenance and reinstatement of methamphetamine self-administration in rhesus monkeys. (2010) (25)
- In vitro and non‐invasive in vivo effects of the cannabinoid‐1 receptor agonist AM841 on gastrointestinal motor function in the rat (2015) (25)
- Fluorescent probes for G-protein-coupled receptor drug discovery (2018) (25)
- Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats (2009) (24)
- Cannabinoid 1 G protein-coupled receptor (periphero-)neutral antagonists: emerging therapeutics for treating obesity-driven metabolic disease and reducing cardiovascular risk (2011) (24)
- C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor. (2012) (24)
- Probing the Carboxyester Side Chain in Controlled Deactivation (−)-Δ8-Tetrahydrocannabinols (2014) (24)
- Diuretic effects of cannabinoid agonists in mice. (2013) (24)
- 3'-functionalized adamantyl cannabinoid receptor probes. (2015) (24)
- Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol. (1999) (24)
- Preparation of iodine‐123 labeled AM251: A potential SPECT radioligand for the brain cannabinoid CB1 receptor (1996) (23)
- Small angle X-ray diffraction and differential scanning calorimetric studies on O-methyl-(-)-delta 8-tetrahydrocannabinol and its 5' iodinated derivative in membrane bilayers. (1995) (23)
- AM630 antagonism of cannabinoid-stimulated [35S]GTP gamma S binding in the mouse brain. (1997) (23)
- Mechanisms of local anesthetic action on the permeability of erythrocytes, leukocytes, and liposomes containing the erythrocyte anion channel protein. (1977) (23)
- Studies on phenethylamine hallucinogens. 2. Conformations of arylmethoxyl groups using 13C NMR. (1981) (23)
- The effect of cholesterol on lipid dynamics and packing in diether phosphatidylcholine bilayers. X-ray diffraction and 2H-NMR study. (1987) (23)
- Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit (2018) (23)
- Solid-state NMR and molecular dynamics characterization of cannabinoid receptor-1 (CB1) helix 7 conformational plasticity in model membranes. (2009) (23)
- Determination of anandamide amidase activity using ultraviolet-active amine derivatives and reverse-phase high-performance liquid chromatography. (1998) (23)
- Cannabinoid receptor and WIN-55,212-2-stimulated [35S]GTPγS binding and cannabinoid receptor mRNA levels in several brain structures of adult male rats chronically exposed to R-methanandamide (1999) (23)
- An unusual reactivity of BBr(3): Accessing tetrahydroisoquinoline units from N-phenethylimides. (2010) (22)
- Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists (2017) (22)
- Classical/non-classical cannabinoid hybrids; stereochemical requirements for the southern hydroxyalkyl chain. (1995) (22)
- Candidate PET radioligands for cannabinoid CB1 receptors: [18F]AM5144 and related pyrazole compounds. (2005) (22)
- Inhibition of N-acylethanolamine acid amidase reduces nicotine-induced dopamine activation and reward (2019) (22)
- Endocannabinoid metabolomics: A novel liquid chromatography-mass spectrometry reagent for fatty acid analysis (2006) (22)
- Synthesis and biological evaluation of benzopyran analogues bearing class III antiarrhythmic pharmacophores. (2006) (22)
- Novel 17β-substituted conformationally constrained neurosteroids that modulate GABAA receptors (2005) (22)
- Impaired neurogenesis by HIV-1-Gp120 is rescued by genetic deletion of fatty acid amide hydrolase enzyme (2015) (22)
- AM2389, a high-affinity, in vivo potent CB1-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice (2012) (22)
- Mechanism of steroid anesthetic action: interactions of alphaxalone and delta 16-alphaxalone with bilayer vesicles. (1983) (22)
- Bifunctional agents for reperfusion arrhythmias: novel hybrid vitamin E/class I antiarrhythmics. (2003) (22)
- Discriminative stimulus functions of AM-1346, a CB1R selective anandamide analog in rats trained with Δ9-THC or (R)-methanandamide (AM-356) (2006) (22)
- Acute and chronic effects of cannabidiol on Δ⁹-tetrahydrocannabinol (Δ⁹-THC)-induced disruption in stop signal task performance. (2016) (21)
- (−)-Adamantyl-Δ8-tetrahydrocannabinol (AM-411), a selective cannabinoid CB1 receptor agonist: effects on open-field behaviors and antagonism by SR-141716 in rats (2004) (21)
- Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats (2008) (21)
- Mass spectrometry-based GPCR proteomics: comprehensive characterization of the human cannabinoid 1 receptor. (2010) (21)
- Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor. (2015) (21)
- Drug Discrimination in Methamphetamine-Trained Monkeys: Effects of Monoamine Transporter Inhibitors (2004) (21)
- Selenol esters as specific reagents of the acylation of thiol groups (1973) (21)
- Effects of Δ9-tetrahydrocannabinol, (R)-methanandamide, SR 141716, and d-amphetamine before and during daily Δ9-tetrahydrocannabinol dosing (2000) (21)
- Intramolecular Heck reactions of aryl chlorides with alkynes (2010) (21)
- 13-Methylarachidonic Acid Is a Positive Allosteric Modulator of Endocannabinoid Oxygenation by Cyclooxygenase* (2015) (21)
- Approximating Protein Flexibility through Dynamic Pharmacophore Models: Application to Fatty Acid Amide Hydrolase (FAAH) (2011) (20)
- Antinociceptive Effects of Racemic AM1241 and Its Chirally Synthesized Enantiomers: Lack of Dependence upon Opioid Receptor Activation (2010) (20)
- NMR solution structure of human cannabinoid receptor-1 helix 7/8 peptide: candidate electrostatic interactions and microdomain formation. (2009) (20)
- Controlled-deactivation cannabinergic ligands. (2013) (20)
- Solid state 2H-NMR as a method for determining the orientation of cannabinoid analogs in membranes (1991) (20)
- A concise methodology for the synthesis of (-)-Δ9-tetrahydrocannabinol and (-)-Δ9-tetrahydrocannabivarin metabolites and their regiospecifically deuterated analogs (2007) (20)
- Novel C-Ring-Hydroxy-Substituted Controlled Deactivation Cannabinergic Analogues. (2016) (20)
- CB1 antagonism: interference with affective properties of acute naloxone-precipitated morphine withdrawal in rats (2014) (20)
- Anesthetic steroid mobility in model membrane preparations as examined by high-resolution 1H and 2H NMR spectroscopy. (1991) (20)
- Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments. (2009) (20)
- Cannabinoid Receptors in Sperm (1999) (20)
- Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in rats. (2006) (20)
- Bornyl- and isobornyl-Delta8-tetrahydrocannabinols: a novel class of cannabinergic ligands. (2008) (20)
- Structural requirements for arachidonylethanolamide interaction with CB1 and CB2 cannabinoid receptors: pharmacology of the carbonyl and ethanolamide groups. (1998) (20)
- Small angle X-ray diffraction studies on the topography of cannabinoids in synaptic plasma membranes (1991) (19)
- Assay and inhibition of diacylglycerol lipase activity. (2012) (19)
- [Anandamide and R-(+)-methanandamide prevent development of ischemic and reperfusion arrhythmia in rats by stimulation of CB2-receptors]. (2002) (19)
- Alkyl and alkoxyethyl antineoplastic phospholipids. (1996) (19)
- Binding between a distal C-terminus fragment of cannabinoid receptor 1 and arrestin-2. (2011) (19)
- The Conformations of 17β-Estradiol (E2) and 17α-Estradiol as Determined by Solution NMR. (2010) (19)
- Novel Insights into CB1 Cannabinoid Receptor Signaling: A Key Interaction Identified between the Extracellular-3 Loop and Transmembrane Helix 2 (2013) (19)
- Albumin enhances the diffusion of lipophilic drugs into the membrane bilayer. (2005) (19)
- A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1. (2021) (19)
- The role of halogen substitution in classical cannabinoids: A CB1 pharmacophore model (2004) (19)
- Azido‐ and Isothiocyanato‐Substituted Aryl Pyrazoles Bind Covalently to the CB1 Cannabinoid Receptor and Impair Signal Transduction (2000) (19)
- Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. (2004) (19)
- Detection of cannabinoid receptors by photoaffinity labelling. (1991) (19)
- Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study. (2013) (18)
- Synthesis of covalent probes for the radiolabeling of the cannabinoid receptor. (2003) (18)
- Antagonism of ∆⁹-THC induced behavioral effects by rimonabant: time course studies in rats. (2010) (18)
- Topography of alphaxalone and Δ16-alphaxalone in membrane bilayers containing cholesterol (1994) (18)
- Conformationally restricted hybrids of CP-55,940 and HHC: Stereoselective synthesis and activity (1994) (18)
- A comparison of novel, selective fatty acid amide hydrolase (FAAH), monoacyglycerol lipase (MAGL) or dual FAAH/MAGL inhibitors to suppress acute and anticipatory nausea in rat models (2016) (18)
- Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist (2015) (18)
- Conformational study of lipophilic ligands in phospholipid model membrane systems by solution NMR. (2003) (18)
- Syntheses of all four stereoisomers which are conformationally constrained 1,4-dioxanyl analogs of the antineoplastic ether lipid ET-18-OCH3 (1992) (18)
- Human Cannabinoid 1 GPCR C-Terminal Domain Interacts with Bilayer Phospholipids to Modulate the Structure of its Membrane Environment (2011) (18)
- Effects of various cannabinoid ligands on choice behaviour in a rat model of gambling (2016) (17)
- Structural modifications of the cannabinoid side chain towards C3-aryl and 1',1'-cycloalkyl-1'-cyano cannabinoids. (2006) (17)
- The conformational analysis of delta 9- and delta 9,11-tetrahydrocannabinols in solution using high resolution nuclear magnetic resonance spectroscopy. (1989) (17)
- Topography of tetrahydrocannabinol in model membranes using neutron diffraction. (1993) (17)
- Synthesis and characterization of 2-substituted bornane pharmacophores for novel cannabinergic ligands. (2008) (17)
- Translational strategies for therapeutic development in nicotine addiction: Rethinking the conventional bench to bedside approach (2014) (17)
- Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats (2014) (17)
- Targeted modulators of the endogenous cannabinoid system: Future medications to treat addiction disorders and obesity (2007) (17)
- Terpenes and lipids of the endocannabinoid and transient-receptor-potential-channel biosignaling systems. (2014) (17)
- C-Attached aminoalkylindoles: potent cannabinoid mimetics (1996) (17)
- Behavioral effects of the novel potent cannabinoid CB1 agonist AM 4054 (2013) (17)
- Identification of endocannabinoids and related N-acylethanolamines in tetrahymena. A new class of compounds for Tetrahymena. (2010) (16)
- The conformational analysis of aromatic methoxyl groups from carbon-13 chemical shifts and spin-lattice relaxation times (1979) (16)
- Prophylactic treatment with the tricyclic antidepressant desipramine prevents development of paclitaxel-induced neuropathic pain through activation of endogenous analgesic systems. (2016) (16)
- Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent (2020) (16)
- Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys (2016) (16)
- Endocannabinoid Metabolome Characterization of Transitional and Mature Human Milk (2018) (16)
- High-resolution NMR and computer modeling studies of the cannabimimetic aminoalkylindole prototype WIN-55212-2. (1999) (15)
- Synthesis and antiretroviral evaluation of new alkoxy and aryloxy phosphate derivatives of 3'-azido-3'-deoxythymidine. (1996) (15)
- Synthesis of deuterium labeled cannabinoids (1988) (15)
- Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy (2018) (15)
- Enantiomeric resolution of a novel chiral cannabinoid receptor ligand. (2002) (15)
- The novel cannabinoid agonist AM 411 produces a biphasic effect on accuracy in a visual target detection task in rats (2005) (14)
- Endocannabinoid regulation of homeostatic feeding and stress‐induced alterations in food intake in male rats (2018) (14)
- A methodology for radiolabeling of the endocannabinoid 2-arachidonoylglycerol (2-AG). (2011) (14)
- Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog (2009) (14)
- Central mediation and differential blockade by cannabinergics of the discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats (2011) (14)
- Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism. (2010) (14)
- The molecular features of membrane perturbation by anaesthetic steroids: a study using differential scanning calorimetry, small angle X-ray diffraction and solid state 2H NMR. (1990) (14)
- Studies of the conformational properties of the cannabimimetic aminoalkylindole pravadoline using NMR and molecular modeling (1995) (14)
- Synthesis and pharmacological properties of 11-hydroxy-3-(1',1'-dimethylheptyl)hexahydrocannabinol: a high-affinity cannabinoid agonist. (1994) (14)
- Conformational studies on a diastereoisomeric pair of tricyclic nonclassical cannabinoids by NMR spectroscopy and computer molecular modeling. (1998) (14)
- The application of solid-state NMR spectroscopy to study candesartan cilexetil (TCV-116) membrane interactions. Comparative study with the AT1R antagonist drug olmesartan. (2014) (14)
- PET studies in the primate brain and biodistribution in mice using (-)-5'-18F-delta 8-THC. (1991) (13)
- Conformational relationships between analogs of acetylcholine and those of local anesthetics in solution. (1972) (13)
- Microwave Assisted Synthesis of Sodium Sulfonates Precursors of Sulfonyl Chlorides and Fluorides. (2009) (13)
- A New Ring-Forming Methodology for the Synthesis of Conformationally Constrained Bioactive Molecules (2001) (13)
- Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligands. (2011) (13)
- Heteroadamantyl cannabinoids. (2010) (13)
- Dynamic conformational responses of a human cannabinoid receptor-1 helix domain to its membrane environment. (2009) (13)
- Highly Predictive Ligand‐based Pharmacophore and Homology Models of ABHD6 (2013) (12)
- Unsaturated side chain beta-11-hydroxyhexahydrocannabinol analogs. (1996) (12)
- Drug Discovery Strategies and Methods (2003) (12)
- Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors. (2019) (12)
- Specific Inter-residue Interactions as Determinants of Human Monoacylglycerol Lipase Catalytic Competency (2015) (12)
- Open vessel mode microwave-assisted synthesis of 2-oxazolines from carboxylic acids. (2009) (12)
- Small angle X-ray diffraction studies of (-)-delta 8-tetrahydrocannabinol and its O-methyl analog in membranes. (1993) (12)
- Design and synthesis of (13S)-methyl-substituted arachidonic acid analogues: templates for novel endocannabinoids. (2010) (12)
- The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome (2018) (11)
- Chemoenzymatic Synthesis of 2-Arachidonoylglycerol, An Endogenous Ligand for Cannabinoid Receptors. (2011) (11)
- Inhibitors of anandamide breakdown. (1997) (11)
- C-ring cannabinoid lactones: a novel cannabinergic chemotype. (2014) (11)
- Effects of a novel CB1 agonist on visual attention in male rats: role of strategy and expectancy in task accuracy. (2013) (11)
- Biochemical and Proteomic Characterization of Recombinant Human α/β Hydrolase Domain 6 (2019) (11)
- The interaction of cannabinoid receptor agonists, CP55940 and WIN55212-2 with membranes using solid state 2H NMR. (2011) (11)
- Refined homology model of monoacylglycerol lipase: toward a selective inhibitor (2009) (11)
- CB1 Receptor Antagonism in the Bed Nucleus of the Stria Terminalis Interferes With Affective Opioid Withdrawal in Rats (2017) (10)
- Expression, Purification and Characterization of the Human Cannabinoid 1 Receptor (2018) (10)
- Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. (2011) (10)
- Differential effects of cannabinoid CB1 inverse agonists and antagonists on impulsivity in male Sprague Dawley rats: identification of a possibly clinically relevant vulnerability involving the serotonin 5HT1A receptor (2017) (10)
- Syntheses of racemic and nearly optically pure ether lipids and evaluation of in vitro antineoplastic activities. (1994) (10)
- Development of novel tail-modified anandamide analogs. (2008) (10)
- Regiospecifically deuterated (−)-Δ9-tetrahydrocannabivarins (2002) (10)
- Chronic low dose arsenic exposure preferentially perturbs mitotic phase of the cell cycle (2018) (10)
- CB1 antagonism produces behaviors more consistent with satiety than reduced reward value in food-maintained responding in rats (2016) (10)
- Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL). (2012) (10)
- ( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes. (2018) (10)
- Interactions of cannabinoids with membranes. The role of cannabinoid stereochemistry and absolute configuration and the orientation of delta-9-THC in the membrane bilayer. (1987) (10)
- Effects of anesthetics on sulfate transport in the red cell (1980) (10)
- Endocannabinoids Are Expressed in Bone Marrow Stromal Niches and Play a Role in Interactions of Hematopoietic Stem and Progenitor Cells with the Bone Marrow Microenvironment* (2010) (9)
- In vitro determination of the CB1 efficacy of illicit synthetic cannabinoids (2018) (9)
- Cannabinoid-2 Agonism with AM2301 Mitigates Morphine-Induced Respiratory Depression. (2020) (9)
- The endocannabinoid 2-arachidonoylglycerol and dual ABHD6/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity (2021) (9)
- Binding Site Characterization of AM1336, a Novel Covalent Inverse Agonist at Human Cannabinoid 2 Receptor, Using Mass Spectrometric Analysis. (2017) (9)
- Therapeutic modulation of cannabinoid lipid signaling: metabolic profiling of a novel antinociceptive cannabinoid-2 receptor agonist. (2013) (9)
- Synthesis and adrenoceptor affinity of some highly polar beta-substituted catecholamines. (1981) (9)
- Conformational analysis of amphetamine in solution based on unambiguous assignment of the diastereotopic benzylic protons in the 1H NMR spectra (1981) (9)
- Design and synthesis of novel prostaglandin E2 ethanolamide and glycerol ester probes for the putative prostamide receptor(s). (2015) (9)
- Conformational preferences of the kappa-selective opioid agonist U50488. A combined molecular mechanics and nuclear magnetic resonance study. (1992) (9)
- Differential scanning calorimetry and small angle x-ray diffraction study of the interaction of (R)-PAF, (R)-ET-18-OME and (R)-Lyso-PAF with model membranes. (1997) (9)
- Effects of the CB1 Receptor Antagonists AM6545 and AM4113 on Insulin Resistance in a High-Fructose High-Salt Rat Model of Metabolic Syndrome (2020) (9)
- Conformationally constrained analogues of 2-arachidonoylglycerol. (2007) (9)
- A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity. (2008) (9)
- Synthesis of side chain specifically deuterated (-)-Δ9-tetrahydrocannabinols (2002) (9)
- Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon (2017) (9)
- Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain (2020) (8)
- Interactions of angiotensin II with membranes using a combination of differential scanning calorimetry and 31P NMR spectroscopy (1996) (8)
- Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment. (2019) (8)
- Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in rats (2007) (8)
- Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols. (2002) (8)
- A lethal synergy induced by phellinus linteus and camptothecin11 in colon cancer cells (2018) (8)
- Cannabinoid CB1 Discrimination: Effects of Endocannabinoids and Catabolic Enzyme Inhibitors (2017) (8)
- Chiral resolution of 1,3-dimethyl-4-phenylpiperidine derivatives using high-performance liquid chromatography with a chiral stationary phase. (1994) (8)
- Alterations in red blood cell sugar transport by nanomolar concentrations of alkyl lysophospholipid. (1990) (8)
- Conformational gating, dynamics and allostery in human monoacylglycerol lipase (2020) (8)
- Title Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM 1172 (2004) (8)
- Conformational requirements for norepinephrine uptake inhibition by phenethylamines in brain synaptosomes. Effects of alpha-alkyl substitution. (1982) (8)
- Syntheses of 2H- and 13C-labeled 1,2-di-O-hexadecyl-sn-glycero-3-phosphoethanolamines and 1,2-di-O-hexadecyl-sn-glycero-3-phosphocholines (1989) (7)
- Application of Chemoenzymatic Hydrolysis in the Synthesis of 2-Monoacylglycerols. (2012) (7)
- [INCREMENT]9-Tetrahydrocannabinol discriminative stimulus effects of AM2201 and related aminoalkylindole analogs in rats (2016) (7)
- The Interaction of Fatty Acid Amide Hydrolase (FAAH) Inhibitors with an Anandamide Carrier Protein Using 19F-NMR (2013) (7)
- Conformational studies on phenethylamine hallucinogens: the role of alpha alkyl substitution. (1978) (7)
- Detailed analysis of food-reinforced operant lever pressing distinguishes effects of a cannabinoid CB1 inverse agonist and dopamine D1 and D2 antagonists (2010) (7)
- The medicinal chemistry of cannabinoids: an overview. (1987) (7)
- Endocannabinoids and Their Synthetic Analogs (2009) (7)
- Enantioselective synthesis of (10S)- and (10R)-methyl-anandamides. (2012) (7)
- Conformational energy differences between side chain alkylated analogues of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane. (1980) (7)
- Selectivity in aromatic fluorination. Introduction of fluorine probes into nabilone (1996) (7)
- Encyclopedia of Spectroscopy and Spectrometry, 2nd Edition (2010) (7)
- Endocannabinoid Metabolome Characterization of Milk from Guatemalan Women Living in the Western Highlands (2019) (7)
- 17β-estradiol (E2) in membranes: Orientation and dynamic properties. (2016) (7)
- The conformation of (-) 8 α and (-) 8 β-hydroxy-δ9-tetrahydrocannabinols and their interactions with model membranes (1988) (7)
- The sesquiterpene beta-caryophyllene oxide attenuates ethanol drinking and place conditioning in mice (2019) (7)
- Development of Pet and Spect Radioligands for Cannabinoid Receptors (2003) (7)
- A direct approach to the determination of the rotational barriers of the acetylcholine and choline molecules. (1979) (6)
- Specific deuteration of phenols and aromatic ethers using boron trifluoride and deuterium oxide (1987) (6)
- Syntheses of 1,2-di-O-palmitoyl-sn-glycero-3-phosphocholine (DPPC) and analogs with 13C- and 2H-labeled choline head groups. (1997) (6)
- Synthesis and anti-HIV Evaluation of Alkyl and Alkoxyethyl Phosphodiester AZT Derivatives (1995) (6)
- The endogenous cannabinoid anandamide produces THC-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase ( FAAH ) but not by inhibition of anandamide transport (2007) (6)
- Author Correction: A new antibiotic selectively kills Gram-negative pathogens (2020) (6)
- Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure (2018) (6)
- N-Acylethanolamine Acid Amidase Inhibition Potentiates Morphine Analgesia and Delays the Development of Tolerance (2021) (6)
- Synthesis and pharmacology of N-cyano-(beta-arylethyl)amines. (1970) (6)
- Synthesis of 15N-, 13C-, and 2H-labeled methanandamide analogs (2003) (6)
- Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology. (2019) (6)
- Pharmacophoric requirements for cannabinoid side chains. Naphthoyl and naphthylmethyl substituted Δ8-tetrahydrocannabinol analogs† (1996) (6)
- Tolerance to the Diuretic Effects of Cannabinoids and Cross-Tolerance to a κ-Opioid Agonist in THC-Treated Mice (2016) (6)
- A CONVENIENT AND EFFECTIVE SYNTHESIS OF 3-(3,5-DIMETHOXYPHENYL)PROPANAL (2002) (6)
- Topography and thermotropic properties of cannabinoids in brain sphingomyelin bilayers. (1996) (6)
- C1'-Azacycloalkyl Hexahydrocannabinols. (2017) (6)
- Chirospecific syntheses of 2H- and 13C-labeled 1-O-alkyl-2-O-alkyl'-sn-glycero-3-phosphoethanolamines and 1-O-alkyl-2-O-alkyl'-sn-glycero-3-phosphocholines. (1990) (6)
- Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells (2017) (6)
- Pro‐depressant‐like effects of CB1 receptor inverse agonists/antagonists in male Sprague‐Dawley rats (2010) (5)
- Long-Lasting In Vivo Effects of the Cannabinoid CB1 Antagonist AM6538 (2018) (5)
- Interference with TGFβ1-Mediated Inflammation and Fibrosis Underlies Reno-Protective Effects of the CB1 Receptor Neutral Antagonists AM6545 and AM4113 in a Rat Model of Metabolic Syndrome (2021) (5)
- N‐Acylethanolamine acid amidase (NAAA) is dysregulated in colorectal cancer patients and its inhibition reduces experimental cancer growth (2021) (5)
- Altered sleep during spontaneous cannabinoid withdrawal in male mice (2022) (5)
- 3-Phenyl-5-quinolinemethanol antimalarials. (1973) (5)
- Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C (2016) (5)
- Cannabis sativa: an overview (2021) (5)
- Magnetically aligned bicelles to study the orientation of lipophilic ligands in membrane bilayers. (2008) (5)
- Maternal Dietary Fatty Acids and Their Relationship to Derived Endocannabinoids in Human Milk (2021) (5)
- Methods for the synthesis of cannabinergic ligands. (2006) (4)
- Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily Delta 9-tetrahydrocannabinol dosing. (2000) (4)
- Conformationally Restricted Hybrids of CP-55,940 and HHC: Stereoselective Synthesis and Activity. (1994) (4)
- Postpartum changes in the endocannabinoid metabolome of human breast milk (2013) (4)
- Cannabinoid Antagonist Drug Discrimination in Nonhuman Primates (2020) (4)
- Aliphatic Azides as Selective Cysteine Labeling Reagents for Integral Membrane Proteins. (2018) (4)
- Oximes short-acting CB1 receptor agonists. (2018) (4)
- Interdigitation of bilayers from ether lipid analogs: (R)-PAF, (R)-Lyso-PAF and the antineoplastic (R)-ET-18-OMe. (1996) (4)
- Separation of Tetrahydrocannabinol Isomers by Reverse-Phase High Pressure Liquid Chromatography (1987) (4)
- Aspirin-triggered metabolites of EFAs. (2011) (4)
- Human Cannabinoid Receptor 2 Ligand-Interaction Motif: Transmembrane Helix 2 Cysteine, C2.59(89), as Determinant of Classical Cannabinoid Agonist Activity and Binding Pose. (2017) (4)
- Novel Conformationally Restricted Tetracyclic Analogues of Δ8‐Tetrahydrocannabinol. (1999) (4)
- Intramolecular Heck Reactions of Aryl Chlorides with Alkynes. (2010) (4)
- Derivative Spectroscopy in Conjunction with Thin Layer Chromatography Applied for Determination of Mixtures of Amino Acids in Baby Food. (1997) (4)
- Chain Substituted Cannabilactones with Selectivity for the CB2 Cannabinoid Receptor (2019) (4)
- Biocatalyzed Regioselective Synthesis in Undergraduate Organic Laboratories: Multistep Synthesis of 2-Arachidonoylglycerol (2016) (4)
- Rational Remodeling of Atypical Scaffolds for the Design of Photoswitchable Cannabinoid Receptor Tools. (2021) (4)
- MECHANISM OF STEROID ANESTHETIC ACTION: INTERACTIONS OF ALPHAXALONE AND Δ16-ALPHAXALONE WITH BILAYER VESICLES (1983) (4)
- N‐acylethanolamine‐hydrolysing acid amidase: A new potential target to treat paclitaxel‐induced neuropathy (2021) (4)
- Pharmacological evaluation of iodo and nitro analogs of delta 8-THC and delta 9-THC. (1993) (4)
- The conformational properties of the antineoplastic ether lipid 1-thiohexadecyl-2-O-methyl-S-glycero-3-phosphocholine. (1996) (4)
- Detection of the endocannabinoid metabolome in human plasma and breast milk (2013) (4)
- Expression and Function of Cannabinoid Receptors CB 1 and CB 2 and Their Cognate Cannabinoid Ligands in Murine Embryonic Stem Cells (2007) (3)
- Novel synthesis of (−)‐trans‐Δ9,11‐tetrahydrocannabinol (1988) (3)
- Secretion, isotopic labeling and deglycosylation of N-acylethanolamine acid amidase for biophysical studies. (2017) (3)
- Application of fluorosome stopped-flow spectrophotometry to monitor the entry of molecules into lipid bilayers (1997) (3)
- Antiemetic Effects of Cannabinoid Agonists in Nonhuman Primates (2020) (3)
- PM288. Preclinical Evaluation of Neutral Cannabinoid CB1 Receptor Antagonists and Cannabinoid CB1 Receptor Negative Allosteric Modulators for Treating Drug Addiction (2016) (3)
- Discriminative‐stimulus and reinforcing effects of FAAH inhibitors in CB‐1 trained subjects (2011) (3)
- The novel cannabinoid CB1 receptor agonist AM11101 increases food intake in female rats (2019) (3)
- Inhibition of triple negative breast cancer-associated inflammation, tumor growth and brain colonization by targeting monoacylglycerol lipase (2022) (3)
- Peripherally administered cannabinoid receptor 2 (CB2R) agonists lose anti-allodynic effects in TRPV1 knockout mice, while intrathecal administration leads to anti-allodynia and reduced GFAP, CCL2 and TRPV1 expression in the dorsal spinal cord and DRG (2021) (3)
- Methods for the Synthesis of Cannabinergic Ligands (2006) (3)
- Preparation of optically pure 4-(hydroxymethyl)-2-pentadecyl-1,3-dioxolanes and their corresponding phosphodiester ether lipid derivatives. (2001) (3)
- A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB2 reporter mouse (2021) (3)
- Untapped endocannabinoid pharmacological targets: Pipe dream or pipeline? (2021) (3)
- Cannabinergics: OLD AND NEW THERAPEUTIC POSSIBILITIES (2003) (3)
- Cognitive effects of psychotomimetic drugs in rats discriminating number cues (2009) (3)
- Inhibition of [3H]5-HT binding to rat brain membranes by psychotomimetic amphetamines. (1982) (3)
- A high efficacy cannabinergic ligand (AM4054) used as a discriminative stimulus: Generalization to other adamantyl analogs and Δ9-THC in rats (2016) (3)
- CONFORMATIONAL REQUIREMENTS FOR NOREPINEPHRINE UPTAKE INHIBITION BY PHENETHYLAMINES IN BRAIN SYNAPTOSOMES. EFFECTS OF α-ALKYL SUBSTITUTION (1983) (3)
- Syntheses of All Four Stereoisomers which are Conformationally Constrained 1,4-Dioxanyl Analogs of the Antineoplastic Ether Lipid ET- 18-OCH3. (1993) (3)
- Novel tail and head group prostamide probes. (2015) (3)
- Studies on phenethylamine hallucinogens. 2. Conformations of arylmethoxyl groups by carbon-13 NMR (1981) (3)
- Targeting the Endocannabinoid System for Neuroprotection: A 19F-NMR Study of a Selective FAAH Inhibitor Binding with an Anandamide Carrier Protein, HSA (2013) (3)
- Ligand-Assisted Protein Structure (LAPS): An Experimental Paradigm for Characterizing Cannabinoid-Receptor Ligand-Binding Domains. (2017) (3)
- Brain Penetrant, but not Peripherally Restricted, Synthetic Cannabinoid 1 Receptor Agonists Promote Morphine-Mediated Respiratory Depression. (2021) (3)
- Probes for the cannabinoid sites of action. (1993) (3)
- Synthesis of Functionalized Cannabilactones (2020) (3)
- N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition, but Not Fatty Acid Amide Hydrolase Inhibition, Prevents the Development of Experimental Autoimmune Encephalomyelitis in Mice (2021) (2)
- Therapeutic Opportunities through the Modulation of Endocannabinoid Transport (2013) (2)
- Design and Structure-Activity Relationships of Isothiocyanates as Potent and Selective N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibitors. (2021) (2)
- Synthesis and characterization of a compact tricyclic resorcinol from (+)- and (-)-3-pinanol. (2012) (2)
- Evidence for spontaneous cannabinoid withdrawal in mice (2021) (2)
- Combined use of solid-state nuclear magnetic resonance spectroscopy, small-angle x-ray diffraction, and differential scanning calorimetry in studies of cannabinoid: membrane interactions. (1991) (2)
- A Reversible FAAH Inhibitor Exhibits Efficient Bioavailability While Enhancing Neuroprotective Endocannabinoid Responses (2006) (2)
- Design and Synthesis of Highly Potent and Specific ABHD6 Inhibitors. (2021) (2)
- Probing the CB1 Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist (2019) (2)
- Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists. (2021) (2)
- 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1. (2021) (2)
- Cannabinoids as Therapeutics. Edited by Raphael Mechoulam. Birkhäuser Verlag, Basel, Switzerland. 2007. x + 272 pp. 16.5 × 24 cm. ISBN 3-7643-7055-6. 136.96 euros. (2007) (2)
- Addition and elimination of HCl to tetrahydrocannabinol isomers. A method for the preparation of stereospecifically 2H-labeled cannabinoids (1998) (2)
- Structural Chemistry Using NMR Spectroscopy, Pharmaceuticals (2010) (2)
- Therapeutic Opportunities through the Modulation of Endocannabinoid (2013) (2)
- Chapter 3. Natural Compounds and Synthetic Drugs to Target Type-1 Cannabinoid (CB1) Receptor (2020) (2)
- How do plasma endocannabinoids and inflammatory markers respond to docosahexaenoic acid (DHA) supplementation in pregnancy? (2011) (2)
- Human cannabinoid receptor-2 helix 6 (2009) (2)
- Novel 17beta-substituted conformationally constrained neurosteroids that modulate GABA A receptors. (2005) (2)
- SELENOL ESTERS AS SPECIFIC REAGENTS FOR THE ACYLATION OF THIOL GROUPS (1974) (2)
- Cannabinoid CB1 and serotonin 5‐HT1A agonists mediate lower lip retraction by independent mechanisms (2012) (1)
- The Molecular Basis of Cannabinoid Activity: Application to Therapeutics Design and Discovery for Cannabis Use Disorders (2018) (1)
- The role of human monoacylglycerol lipase (hMAGL) binding pocket in breakup of unsaturated phospholipid membranes. (2017) (1)
- Corrigendum: Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite (2021) (1)
- Topography of alphaxalone and delta 16-alphaxalone in membrane bilayers containing cholesterol. (1994) (1)
- Structure activity correlations in the inhibition of brain synaptosomal 3H-norepinephrine uptake by phenethylamine analogs. The role of alpha-alkyl side chain and methoxyl ring substitutions. (1982) (1)
- Possible Efficacy Related Differences Among Cannabinoid Agonists (2013) (1)
- Discriminative stimulus effects of methamphetamine and in vivo microdialysis in rats (2007) (1)
- Oxa-Adamantyl Cannabinoids. (2021) (1)
- Antidotes for Acute Cannabinoid Intoxication (2019) (1)
- Selective cannabinoid receptor 2 (CB2R) agonist AM1710 acts independently of cannabinoid receptor 1 (CB1R) responses in neuropathic CB1R -/- mice (2012) (1)
- Nortropacocaine hydrochloride conformation in aqueous and hydrophobic media. (1979) (1)
- Pharmacological evaluation of halogenated delta 8-THC analogs. (1991) (1)
- Hydrogen‐Bonded His93 As a Sensitive Probe for Identifying Inhibitors of the Endocannabinoid Transport Protein FABP7 (2015) (1)
- Single crystal X-ray structures of the two 4-heptadecyl derivatives of (1R,5S)-3,6,8-trioxabicyclo[3.2.1]octane. (1995) (1)
- Solvent effects in the NMR spectra of cyano compounds. (1970) (1)
- Crystal structure of the human CB1 in complex with agonist AM11542 (2017) (1)
- Irt>t schedule controlled behavior in ‘learned-helpless’ rats: Effects from a cannabinoid agonist (2006) (1)
- Human Cannabinoid 2 GPCR Ligand-interaction Landscape: Cysteine Residues Critical to Biarylpyrazole Antagonist Binding Motif and Receptor Modulation (2011) (1)
- Chronic cannabinoid CB 2 activation reverses paclitaxel neuropathy without tolerance or CB 1 -dependent withdrawal (2015) (1)
- An Unusual Reactivity of BBr3: Accessing Tetrahydroisoquinoline Units from N-Phenethylimides. (2011) (1)
- Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite (2020) (1)
- W1697 Regional Specificity of Fatty Acid Amide Hydrolase (FAAH) Inhibition On Contractility in the Mouse Intestine: Endotoxin Upregulation of Faah Sensitivity in the Ileum (2009) (1)
- Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy. (2022) (1)
- Plasma and brain endocannabinoid level correlation studies after increasing DHA dietary intake (2007) (1)
- Additions and Corrections - Synthesis and Pharmacology of N-Cyano-(β-arylethyl)amines. (1971) (1)
- Endocannabinoids: Discovery of a unique signaling system for regulating sperm function and fertilization. (2001) (1)
- 276 SELECTIVE ACTIVATION OF CANNABINOID CB2 RECEPTORS SUPPRESSES CHEMOTHERAPEUTIC NEUROPATHY EVOKED BY PACLITAXEL AND VINCRISTINE ADMINISTRATION (2007) (1)
- Increases in Locomotor Activity during Spontaneous Cannabinoid Withdrawal in Mice (2016) (1)
- Effects of cannabinoid exposure on short-term memory and medial orbitofrontal cortex function and chemistry in adolescent female rhesus macaques (2022) (1)
- Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of neuropathic pain (2022) (1)
- Pharmacophoric Requirements for Cannabinoid Side Chains. Naphthoyl and Naphthylmethyl Substituted δ8‐Tetrahydrocannabinol Analogues. (1996) (1)
- Hallucinogenic receptor models: interaction of imidazolium chloride with amphetamine analogs. (1993) (1)
- Role of CB1 receptors in the acute regulation of small intestinal permeability: Effects of high-fat diet. (2022) (1)
- Enhancement of endogenous cannabinoid responses through FAAH inhibition provides cellular and functional protection against excitotoxic brain damage. (2007) (1)
- Synthesis of 15N and 13C selectively labeled anandamide (2002) (1)
- Differentiation of CB1 cannabinoid agonists in rats (2009) (1)
- 17 β-estradiol ( E 2 ) in membranes : Orientation and dynamic properties (2015) (1)
- Bioactive ether lipids: synthesis and biological activity (1999) (0)
- A new antibiotic selectively kills Gram-negative pathogens (2019) (0)
- Selective modulation of the endocannabinoid system for targeted protection in kainic acid models of excitotoxicity (2011) (0)
- Effects of the cannabinoid CB1-receptor neutral antagonist AM4113 and antagonist/inverse agonist rimonabant on fentanyl discrimination in male rats. (2022) (0)
- Blockade of CB1 or Activation of CB2 Cannabinoid Receptors Is Differentially Efficacious in the Treatment of the Early Pathological Events in Streptozotocin-Induced Diabetic Rats (2022) (0)
- Studies of the Brain Cannabinoid System Using Positron and Single-Photon Emission Tomography (1999) (0)
- A Ligand Based Structural Biology Approach for the Characterization of the Cannabinoid Receptor Binding Domains (2007) (0)
- The Interaction of Fatty Acid Amide Hydrolase (FAAH) Inhibitors with an Anandamide Carrier Protein Using 19F-NMR (2013) (0)
- Physiological and behavioral effects of novel CB1‐receptor agonists AM 411 and AM 4054 in monkeys (2006) (0)
- (R)-METHANADAMIDE AS A DISCRIMINATIVE STIMULUS IN RATS: TESTS WITH ANANDAMIDE AND A9‐THC (1998) (0)
- Anandamide amidaseinhibitoren as analgesics (1997) (0)
- H.6 - EFFECTS OF ANANDAMIDE AND OTHER CB1 LIGANDS ON LEARNING AND COGNITIVE FLEXIBILITY IN NONHUMAN PRIMATES (2013) (0)
- The emerging relationship between the endocannabinoid metabolome, inflammation, and pregnancy (2012) (0)
- Partial Agonist and Antagonist Effects of Δ9‐tetrahydrocannabinol (Δ9THC) in rats (2007) (0)
- Young Scientists Forum (2008) (0)
- Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys (2016) (0)
- CB1‐Like Behavioral Effects of the Novel FAAH inhibitor AM3506 (2013) (0)
- 328 – Preclinical Drug Evaluation Reveals Inhibition of Nacylethanolamine Acid Amidase As a Potential Treatment for Inflammatory Bowel Disease (2019) (0)
- List of contributors (2021) (0)
- The Mechanism of the Disintegration of Phospholipid Membranes with Human Monoacylglycerol Lipase (hMGL) (2015) (0)
- Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase – Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology (2012) (0)
- Human cannabinoid receptor 1 - helix 7/8 peptide (2009) (0)
- Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon (2017) (0)
- Cannabinoid-induced lower lip retraction in rats (2018) (0)
- Author response for "Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain" (2020) (0)
- New bicyclic cannabinoid agonists for cannabinoid-receptor (2000) (0)
- Title Potentiation of anandamide hypotension by the transport inhibitor , AM 404 Permalink (1997) (0)
- PKC is an indispensable factor in promoting environmental toxin chromium-mediated transformation and drug resistance (2022) (0)
- Biochemical and Pharmacological Characterization of Human a/ß Hydrolase Domain 6 (2015) (0)
- Protein Misfolding and Neurodegenerative Disease (2003) (0)
- ErratumHigh-Performance Liquid Chromatographic Determination of Anandamide Amidase Activity in Rat Brain Microsomes: Volume238,Number 1 (1996), pages 40–45: (1996) (0)
- Expression, Purification and Characterization of the Human Cannabinoid 1 Receptor (2018) (0)
- Structure-based discovery of cannabinoid-1 receptor agonists with reduced side effects (2023) (0)
- AM2389, a high-affinity, in vivo potent CB1-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice (2011) (0)
- Inhibition of endocannabinoid‐inactivating enzymes and cannabinoid (CB1) discrimination (838.1) (2014) (0)
- Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats (2013) (0)
- Evaluation of CB1 antagonists as antidotes for synthetic cannabinoid toxicity in male and female mice (2020) (0)
- Regulation of Stem Cells by the Endocannabinoid System (2012) (0)
- Conference Proceeding: Dissociable effects of dopamine antagonists and cannabinoid CB1 antagonists: studies using the concurrent progressive ratio/chow feeding task (2012) (0)
- The Synthesis of Potential 3-Phenylquinoline Antimalarials a-Aminomethyl-3-Phenyl-5-Quinolinemethanols. (1970) (0)
- Site‐directed Mutagenesis in tandem with selective ligands to better understand the tertiary structure of GPCRs (2007) (0)
- WITHDRAWN: Design and synthesis of highly potent dual ABHD6/MGL inhibitors (2021) (0)
- Open Vessel Mode Microwave‐Assisted Synthesis of 2‐Oxazolines from Carboxylic Acids. (2010) (0)
- Optimization of a Medium‐Throughput Cathepsin K Inhibition Assay for NAAA Inhibitors (2017) (0)
- Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists (2021) (0)
- Cannabinoid Cb 1 Receptor Antagonists/Inverse Agonists and Food-Seeking Behavior (2011) (0)
- Relationship Between Endocannabinoids During Pregnancy and Infant Heart Rate and Heart Rate Variability (2021) (0)
- Evaluation of FAAH‐ and MGL‐Inhibition in Cannabinoid Drug Discrimination (2015) (0)
- How to Probe the Sites of Action of Drug Molecules (2008) (0)
- Erratum to: CB1 antagonism: interference with affective properties of acute naloxone-precipitated morphine withdrawal in rats (2014) (0)
- Administration of AM 1241, a cannabinoid 2 (CB2) receptor selective agonist, to the rodent spinal cord reverses Chronic Constriction Injury (CCI) induced allodynia (2009) (0)
- Spontaneous and rimonabant‐precipitated cannabinoid withdrawal in Δ9‐tetrahydrocannabinol and AM2389‐treated mice (838.5) (2014) (0)
- Discriminative‐stimulus effects of the novel CB1 agonist AM 4054 in squirel monkeys (2008) (0)
- Discriminative Stimulus Effects of (R)(−)‐DOI and AM8936, a Synthetic Cannabinoid (2020) (0)
- Microsoft Word-65948399-file00 (2011) (0)
- Reconstitution of Human Cannabinoid 2 Receptor into Nanodiscs for Mass Spectrometric Studies (2015) (0)
- Targeting Monoacylglycerol Lipase in Triple Negative Breast Cancer Reduced Tumor-Associated Inflammation, Tumor Growth and Tumor Colonization in the Brain (2021) (0)
- ANTIHYPERTENSIVE EFFECT OF THE NOVEL FAAH INHIBITOR AM3506 (2009) (0)
- Substrate-selective activation of COX-2 by AM-8138 (2015) (0)
- Corrigendum to "The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome" [Eur. J. Pharmacol. (2018), 836 34-43]. (2019) (0)
- Behavioral Effects of d‐Methamphetamine and sin vivo microdialysis in rats (2020) (0)
- Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats (2015) (0)
- Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase (2018) (0)
- Targeted lipidomics: endocannabinoids and other endolipid modulators (2005) (0)
- Inhibition of triple negative breast cancer-associated inflammation and progression by N- acylethanolamine acid amide hydrolase (NAAA) (2022) (0)
- Functional analysis of key residues involved in CB1 and CB2 activation (2022) (0)
- Protection from and Reemergence of Extinction (2009) (0)
- Crystal structure of an agonist bound GPCR (2020) (0)
- Regiospecifically Deuterated (-)-Δ9-Tetrahydrocannabivarins. (2003) (0)
- Cryo-EM structure of a class A GPCR with G protein complex (2020) (0)
- Crystal structure of the meta hydroxyl phenyl analog of α(+)-prodine (1996) (0)
- A Novel Monoacylglycerol Lipase Inhibitor with Analgesic and Antiinflammatory Activity. (2009) (0)
- Cryo-EM structure of CB1-G protein complex (2020) (0)
- Carbon-13 and proton magnetic resonance spectra of 2,4-disubstituted 3,3-diphenyltetrahydrofurans derived from isomethadone and isomethadol (1979) (0)
- Experimental evidence for Tyr171 involvement in catalytic cleavage by apurinic/apyrimidinic endonuclease (AP endo) (2006) (0)
- The interactions of cannabinoids with membranes as studied by DSC and solid state NMR (1999) (0)
- Proton Nuclear Magnetic Resonance Spectral Resolution of Enantiomeric Amino Acid Tyrosine (2001) (0)
- The conformation of (-) 8 alpha and (-) 8 beta-hydroxy-delta 9-tetrahydrocannabinols and their interactions with model membranes. (1988) (0)
- New selective cannabinoid CB2 to the receiver. (1999) (0)
- Selectivity in Aromatic Fluorination. Introduction of Fluorine Probes into Nabilone. (1997) (0)
- Use of molecular graphics as an aid in the study of conformational properties of aminoalkylindole pravadoline and the analgesic cannabinoid CP-55,940 (1995) (0)
- Analgesic and immunomodulating cannabinoid (1999) (0)
- Endocannabinioid system : a source for drug discovery, The (2017) (0)
- A Convenient and Effective Synthesis of 3‐(3,5‐Dimethoxyphenyl)propanal. (2010) (0)
- Novel Synthesis of (-)-trans-δ9,11-Tetrahydrocannabinol (I). (1989) (0)
- Effects of Distal Residues Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase | NIST (2018) (0)
- Cannabinoid mediated diuresis in mice (2011) (0)
- A New Ring-Forming Methodology for the Synthesis of Conformationally Constrained Bioactive Molecules. (2001) (0)
- Pharmacokinetics of [11C]-labeled aminoalkylindole derivatives for PET imaging of cannabinoid CB1 receptors in baboons (2008) (0)
- 3-PHENYL-5-CHINOLIN-METHANOLE ALS MALARIAMITTEL (1973) (0)
- Elusive anesthesia. Drug and anesthetic effects on membrane structure and function (1991). Edited by Roland C. Aloia, Cyril C. Curtain, Larry M. Gordon. Wiley-Liss, New York $185/£128. 304pp. ISBN 0-471-56877-5 (1992) (0)
- CONFORMATIONAL ENERGY DIFFERENCES BETWEEN SIDE CHAIN ALKYLATED ANALOGS OF THE HALLUCINOGEN 1-(2,5-DIMETHOXY-4-METHYLPHENYL)-2-AMINOPROPANE (1980) (0)
- Specific perturbations in erythrocyte membranes and lipid bilayers by anesthetic steroids (1980) (0)
- Recent advances in the field of cannabinoids: Synthesis of novel analogs and their interactions with membranes (1995) (0)
- Role of the NH 2-terminal Domain of Angiotensin I 1 ( ANG 11 ) and [ SarllAngiotensin I 1 on Conformation and Activity NMR (2001) (0)
- Modulation of cannabinoid receptor signaling by endocannabinoids (2022) (0)
- Author Correction: A new antibiotic selectively kills Gram-negative pathogens (2020) (0)
- Selectively to the CB2 receptor cannabinoid acting (1999) (0)
- P-194 Cannabinoids can alter human sperm acrosome reactions (AR) (1997) (0)
- Biochemical and Proteomic Characterization of Recombinant Human α/β Hydrolase Domain 6 (2019) (0)
- Novel 1′,1′‐Chain Substituted Δ8‐Tetrahydrocannabinols. (2003) (0)
- Cannabinoid 1 Receptor Mutants and Covalent Cannabinergic Probes for Ligand Binding Site Characterization (2015) (0)
- Synthesis of 2H‐labeled alkoxyethyl phosphodiester (AZT) derivatives for solid‐state 2H‐NMR studies (1996) (0)
- Carbohydrate Modifications in Antisense Research. Edited by Yogesh S. Sanghvi, and P. Dan Cook, ACS Symposium Series 580. American Chemical Society; Washington, DC, 1994, VII- + 232pp. $ 47.00. ISBN 0-8412-3056-0. (1996) (0)
- β-(2-Hydroxyphenyl)ethanolamine hydrochloride [2-amino-1-(2-hydroxyphenyl)ethanol hydrochloride] (1979) (0)
- crystal structure of murine cyclooxygenase-2 with 13-methyl-arachidonic Acid (2015) (0)
- P-402: Fertility loss in the sperm of tobacco smokers may be reversed after washing with a cannabinoid agonist (2006) (0)
- United States Patent ( 10 ) Patent No . : US 7 , 666 , 867 B 2 (2017) (0)
- Corrigendum to "Oxa-adamantyl cannabinoids" [Bioorg. Med. Chem. Lett. 38 (2021) 127882]. (2022) (0)
- Endocannabinoid proteins and ligands (2002) (0)
- SYNTHESIS AND ADRENOCEPTOR AFFINITY OF SOME HIGHLY POLAR β-SUBSTITUTED CATECHOLAMINES (1982) (0)
- Cannabinoids selectively acting on the CB2 receptor (1999) (0)
- Conformational Analysis of the Opioid Phenylmorphan and Its 9α-Methyl Analogue in Solution Using High-Resolution Nuclear Magnetic Resonance Spectroscopy (1993) (0)
- Effects of Cannabinoid Agonists and Antagonists in Rats Discriminating Fentanyl (2022) (0)
- Emerging Technologies and New Directions in Drug Abuse Research : (NIDA Research Monograph ; 112) (1991) (0)
- Cannabinoid CB1 receptor neutral antagonist AM4113 inhibits heroin self-administration without depressive side effects in rats (2018) (0)
- Correction: Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells (2023) (0)
- The Novel Cannabinoid CB1 Receptor Neutral Antagonist Am4113 Suppresses Food Intake and Food-Reinforced Behavior but Does not Induce Signs of Nausea in Rats (2008) (0)
- 155. Cannabis Use is Associated With Low Plasma Endocannabinoid Anandamide in Individuals With Psychosis (2023) (0)
- Integrated ligand based pharmacophore model derived from diverse FAAH covalent ligand classes. (2012) (0)
- Regulation of plasma endocannabinoids differs in pregnant versus non‐pregnant women (2009) (0)
- Antagonism of CB1‐mediated discriminative‐stimulus effects by CB1 neutral and inverse‐agonist antagonists (2012) (0)
- Differential Enantiomer-Specific Signaling of Cannabidiol at CB1 Receptors (2022) (0)
- A comparison of novel, selective fatty acid amide hydrolase (FAAH), monoacyglycerol lipase (MAGL) or dual FAAH/MAGL inhibitors to suppress acute and anticipatory nausea in rat models (2016) (0)
- Partial Agonist and Antagonist Effects of {Delta}9-tetrahydrocannabinol ({Delta}9THC) in rats (2007) (0)
- Response of Plasma Endocannabinoids to Pregnancy and Docosahexaenoic Acid (DHA, 22:6 N-3) Supplementation (2009) (0)
- Novel Insights into CB1 Cannabinoid Receptor Signaling: A Key Interaction Identified between the Extracellular-3 Loop and Transmembrane Helix 2 s (2013) (0)
- Effects of a Selective Cannabinoid Agonist and Antagonist on Body Temperature in Rats (2007) (0)
- CB1 antagonism: interference with affective properties of acute naloxone-precipitated morphine withdrawal in rats (2014) (0)
- 272 SELF‐ADMINISTRATION OF A CANNABINOID CB2 AGONIST IN AN ANIMAL MODEL OF NEUROPATHIC PAIN (2007) (0)
- Cannabinoid-induced lower lip retraction in rats (2018) (0)
- Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist (2015) (0)
- A Nuclear Messenger Links Cannabinoid-1 (CB1) Signalling to Fatty Liver (2016) (0)
- Effects of Chronic Exposure to the CB1 Agonist AM 411 in Squirrel Monkeys (2009) (0)
- P.204 Effect of N-acylethanolamine acid amidase inhibition on locus coeruleus noradrenergic neuronal responses to morphine (2020) (0)
- Erratum to: CB1 antagonism: interference with affective properties of acute naloxone-precipitated morphine withdrawal in rats (2014) (0)
- Mandarin Translations (2012) (0)
- Differential effects of cannabinoid CB1 inverse agonists and antagonists on impulsivity in male Sprague Dawley rats: identification of a possibly clinically relevant vulnerability involving the serotonin 5HT1A receptor (2017) (0)
- Electron paramagnetic resonance characterization of drug‐binding to monoacylglycerol lipase using the dynamic signature of a protein spin‐label (779.3) (2014) (0)
- Synthon-based ligand discovery in virtual libraries of over 11 billion compounds (2021) (0)
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Other Resources About Alexandros Makriyannis
What Schools Are Affiliated With Alexandros Makriyannis?
Alexandros Makriyannis is affiliated with the following schools:
- University of Calgary
- University of Freiburg
- California Institute of Technology
- KU Leuven
- Cairo University
- University of Ioannina
- University of Kansas
- Stanford University
- University of Washington
- Northeastern University
- University of Aberdeen
- University of Connecticut
- University of Crete
- King Abdulaziz University
