Alfred Ayala
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Engineering Computer Science
Alfred Ayala's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
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(Suggest an Edit or Addition)Alfred Ayala's Published Works
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Published Works
- MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis (2007) (663)
- EFFECT OF GENDER AND SEX HORMONES ON IMMUNE RESPONSES FOLLOWING SHOCK (2000) (505)
- PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis (2009) (432)
- Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males. (1997) (373)
- The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients. (2008) (329)
- Leukocyte apoptosis and its significance in sepsis and shock (2005) (320)
- EVIDENCE FAVORING THE ROLE OF THE GUT AS A CYTOKINE‐GENERATING ORGAN IN RATS SUBJECTED TO HEMORRHAGIC SHOCK (1994) (294)
- The Complex Pattern of Cytokines in Sepsis Association Between Prostaglandins, Cachectin, and Interleukins (1991) (272)
- Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients (2009) (262)
- Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators. (1996) (257)
- Early kidney TNF-α expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion. (1999) (255)
- Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation. (1996) (245)
- Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients (2011) (245)
- Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis. (1997) (205)
- Regulatory T cell populations in sepsis and trauma (2008) (204)
- The new normal: immunomodulatory agents against sepsis immune suppression. (2014) (198)
- Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage. (1991) (188)
- Female Sex Hormones Regulate Macrophage Function After Trauma-Hemorrhage and Prevent Increased Death Rate From Subsequent Sepsis (2002) (186)
- In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. (2005) (184)
- IMMUNE DYSFUNCTION IN MURINE POLYMICROBIAL SEPSIS: MEDIATORS, MACROPHAGES, LYMPHOCYTES AND APOPTOSIS (1996) (184)
- Mechanism of immunosuppression in males following trauma-hemorrhage. Critical role of testosterone. (1996) (182)
- Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin. (1990) (180)
- Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis. (2005) (175)
- Mechanism of enhanced susceptibility to sepsis following hemorrhage. Interleukin-10 suppression of T-cell response is mediated by eicosanoid-induced interleukin-4 release. (1994) (175)
- Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T (2015) (172)
- Early kidney TNF-alpha expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion. (1999) (168)
- Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-gamma release while increasing IL-4/IL-10 production. (1994) (164)
- Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency. (2002) (162)
- The apoptotic pathway as a therapeutic target in sepsis. (2007) (160)
- Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern (2012) (157)
- Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes. (1996) (153)
- Fas-induced pulmonary apoptosis and inflammation during indirect acute lung injury. (2007) (152)
- Pathogenesis of indirect (secondary) acute lung injury (2011) (149)
- Male sex steroids are responsible for depressing macrophage immune function after trauma-hemorrhage. (1997) (144)
- Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock (2007) (143)
- Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage. (1997) (143)
- What is the role of interleukin 10 in polymicrobial sepsis: anti-inflammatory agent or immunosuppressant? (1999) (139)
- TRAUMA-HEMORRHAGE CAUSES PROLONGED DEPRESSION IN CELLULAR IMMUNITY (1995) (139)
- Role of alveolar macrophage and migrating neutrophils in hemorrhage-induced priming for ALI subsequent to septic challenge. (2006) (138)
- THE INDUCTION OF ACCELERATED THYMIC PROGRAMMED CELL DEATH DURING POLYMICROBIAL SEPSIS: CONTROL BY CORTICOSTEROIDS BUT NOT TUMOR NECROSIS FACTOR (1995) (136)
- Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. (1997) (134)
- Hemorrhage and resuscitation: immunological aspects. (1990) (133)
- In vivo gene silencing (with siRNA) of pulmonary expression of MIP‐2 versus KC results in divergent effects on hemorrhage‐induced, neutrophil‐mediated septic acute lung injury (2005) (133)
- Prolactin administration following hemorrhagic shock improves macrophage cytokine release capacity and decreases mortality from subsequent sepsis. (1996) (130)
- Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity (2003) (128)
- THE CONTRIBUTION OF CD4+ CD25+ T-REGULATORY-CELLS TO IMMUNE SUPPRESSION IN SEPSIS (2007) (127)
- The loss of Mcl‐1 expression in human polymorphonuclear leukocytes promotes apoptosis (2000) (127)
- 17 beta-Estradiol normalizes immune responses in ovariectomized females after trauma-hemorrhage. (2001) (121)
- Immune dysfunction following trauma-haemorrhage: influence of gender and age. (2000) (120)
- SHOCK AND HEMORRHAGE: AN OVERVIEW OF ANIMAL MODELS (2005) (120)
- Do female sex steroids adversely or beneficially affect the depressed immune responses in males after trauma-hemorrhage? (2000) (116)
- Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhage. (1999) (116)
- ROLE OF KUPFFER CELLS IN INTERLEUKIN‐6 RELEASE FOLLOWING TRAUMA‐HEMORRHAGE AND RESUSCITATION (1994) (114)
- Prolonged immunodepression after trauma and hemorrhagic shock. (1998) (110)
- Differential effects of hemorrhage on Kupffer cells: decreased antigen presentation despite increased inflammatory cytokine (IL-1, IL-6 and TNF) release. (1992) (105)
- TNFalpha-induced suppression of PMN apoptosis is mediated through interleukin-8 production. (2000) (103)
- Biomarkers for Sepsis: What Is and What Might Be? (2015) (101)
- Chloroquine attenuates hemorrhagic shock-induced suppression of Kupffer cell antigen presentation and major histocompatibility complex class II antigen expression through blockade of tumor necrosis factor and prostaglandin release. (1991) (100)
- Hypoxemia in the absence of blood loss or significant hypotension causes inflammatory cytokine release. (1995) (99)
- Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model (2016) (96)
- Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigens. (1990) (95)
- Epithelial Cell Apoptosis and Neutrophil Recruitment in Acute Lung Injury—A Unifying Hypothesis? What We Have Learned from Small Interfering RNAs (2008) (95)
- Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. (2009) (94)
- Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (interleukins-1 and -6 and tumor necrosis factor). (1992) (93)
- Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin-mediated process. (1998) (93)
- Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis? (1998) (93)
- p38 MAPK mediates renal tubular cell TNF-α production and TNF-α-dependent apoptosis during simulated ischemia (2001) (93)
- Effects of trauma, duration of hypotension, and resuscitation regimen on cellular immunity after hemorrhagic shock (1994) (90)
- Human Myocardial Tissue TNFαExpression Following Acute Global IschemiaIn Vivo (1998) (90)
- Diltiazem restores IL-2, IL-3, IL-6, and IFN-gamma synthesis and decreases host susceptibility to sepsis following hemorrhage. (1991) (89)
- Testosterone: the culprit for producing splenocyte immune depression after trauma hemorrhage. (1998) (88)
- Does endotoxin tolerance prevent the release of inflammatory monokines (interleukin 1, interleukin 6, or tumor necrosis factor) during sepsis? (1992) (88)
- Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage. (1998) (87)
- Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis (2018) (85)
- Pulmonary contusion causes impairment of macrophage and lymphocyte immune functions and increases mortality associated with a subsequent septic challenge* (2005) (83)
- POLYMICROBIAL SEPSIS INDUCES DIVERGENT EFFECTS ON SPLENIC AND PERITONEAL DENDRITIC CELL FUNCTION IN MICE (2004) (82)
- Differential Alterations in Cardiovascular Responses During the Progression of Polymicrobial Sepsis in the Mouse (2002) (82)
- Dehydroepiandrosterone restores immune function following trauma-haemorrhage by a direct effect on T lymphocytes. (1999) (82)
- Effects of hydroxyethyl starch after trauma-hemorrhagic shock: restoration of macrophage integrity and prevention of increased circulating interleukin-6 levels. (1995) (81)
- BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction (2012) (80)
- Immune depression in polymicrobial sepsis: The role of necrotic (injured) tissue and endotoxin (2000) (80)
- Severe depression of host immune functions following closed-bone fracture, soft-tissue trauma, and hemorrhagic shock. (1998) (79)
- Differential Effects of Macrophage Inflammatory Chemokine-2 and Keratinocyte-Derived Chemokine on Hemorrhage-Induced Neutrophil Priming for Lung Inflammation: Assessment by Adoptive Cells Transfer in Mice (2003) (79)
- Role of interleukin 6 and transforming growth factor-beta in the induction of depressed splenocyte responses following sepsis. (1993) (78)
- Adenosine decreases post‐ischaemic cardiac TNF‐α production: anti‐inflammatory implications for preconditioning and transplantation (1997) (78)
- Tumor necrosis factor-alpha produces hepatocellular dysfunction despite normal cardiac output and hepatic microcirculation. (1993) (77)
- Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. (2007) (77)
- Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (2018) (77)
- Testosterone and estrogen differently effect Th1 and Th2 cytokine release following trauma-haemorrhage. (2001) (76)
- CXCR2 inhibition suppresses hemorrhage‐induced priming for acute lung injury in mice (2004) (76)
- Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity. Involvement of cell-associated tumor necrosis factor and reactive nitrogen. (1991) (76)
- The release of transforming growth factor-beta following haemorrhage: its role as a mediator of host immunosuppression. (1993) (74)
- MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsis. (2001) (74)
- B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients (2013) (73)
- Mechanism of the beneficial effects of pentoxifylline on hepatocellular function after trauma hemorrhage and resuscitation. (1992) (72)
- Mechanism of increased susceptibility to infection following hemorrhage. (1993) (72)
- Enhanced susceptibility to sepsis after simple hemorrhage. Depression of Fc and C3b receptor-mediated phagocytosis. (1990) (72)
- Lymphocytes in the Development of Lung Inflammation: A Role for Regulatory CD4+ T Cells in Indirect Pulmonary Lung Injury1 (2009) (71)
- Insights into the role of γδ T lymphocytes in the immunopathogenic response to thermal injury (2000) (71)
- Evolution of an immune suppressive macrophage phenotype as a product of P38 MAPK activation in polymicrobial sepsis. (2001) (71)
- Is sepsis-induced apoptosis associated with macrophage dysfunction? (1996) (70)
- Mechanism of the beneficial effects of ATP-MgCl2 following trauma-hemorrhage and resuscitation: downregulation of inflammatory cytokine (TNF, IL-6) release. (1992) (69)
- Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets. (2008) (68)
- Suppression of PMN apoptosis by hypoxia is dependent on Mcl-1 and MAPK activity. (2000) (65)
- Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge. (1996) (65)
- Interferon-gamma attenuates hemorrhage-induced suppression of macrophage and splenocyte functions and decreases susceptibility to sepsis. (1992) (65)
- Mechanism of intestinal mucosal immune dysfunction following trauma-hemorrhage: increased apoptosis associated with elevated Fas expression in Peyer's patches. (1997) (64)
- Ibuprofen restores cellular immunity and decreases susceptibility to sepsis following hemorrhage. (1992) (64)
- MyD 88-dependent expansion of an immature GR-1 + CD 11 b + population induces T cell suppression and Th 2 polarization in sepsis (2007) (64)
- Sex-specific p38 MAP kinase activation following trauma-hemorrhage: involvement of testosterone and estradiol. (2003) (62)
- IL-10 mediation of activation-induced TH1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis. (2001) (62)
- Role of Activated Neutrophils in Chest Trauma–Induced Septic Acute Lung Injury (2012) (61)
- Identification of B7-H1 as a Novel Mediator of the Innate Immune/Proinflammatory Response as well as a Possible Myeloid Cell Prognostic Biomarker in Sepsis (2014) (61)
- Epithelial apoptosis in mechanistically distinct methods of injury in the murine small intestine. (2007) (60)
- Blockade of prostaglandin production increases cachectin synthesis and prevents depression of macrophage functions after hemorrhagic shock. (1991) (60)
- Trauma-hemorrhage delays wound healing potentially by increasing pro-inflammatory cytokines at the wound site. (1999) (58)
- Anti-inflammatory mechanisms of sepsis. (2011) (58)
- Pathological aspects of apoptosis in severe sepsis and shock? (2003) (57)
- Mechanism of splenic immunosuppression during sepsis: key role of Kupffer cell mediators. (1997) (57)
- PAD4 Deficiency Leads to Decreased Organ Dysfunction and Improved Survival in a Dual Insult Model of Hemorrhagic Shock and Sepsis (2018) (56)
- Gender dimorphism in trauma-hemorrhage-induced thymocyte apoptosis. (1999) (56)
- Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhage. (1999) (56)
- Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis. (2001) (54)
- DEFICIENCY OF γδ T-LYMPHOCYTES CONTRIBUTES TO MORTALITY AND IMMUNOSUPPRESSION IN SEPSIS (2006) (54)
- The Role of Hepatic Invariant NKT Cells in Systemic/Local Inflammation and Mortality during Polymicrobial Septic Shock1 (2009) (53)
- CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL. (2007) (53)
- Reversal of sexual dimorphism in splenic T lymphocyte responses after trauma-hemorrhage with aging. (2000) (53)
- Cytokine gene expression in splenic macrophages and Kupffer cells following haemorrhage. (1995) (53)
- Modulation of macrophage membrane phospholipids by n-3 polyunsaturated fatty acids increases interleukin 1 release and prevents suppression of cellular immunity following hemorrhagic shock. (1993) (51)
- p38 MAPK mediates renal tubular cell TNF-alpha production and TNF-alpha-dependent apoptosis during simulated ischemia. (2001) (51)
- Contribution of anti-inflammatory/immune suppressive processes to the pathology of sepsis. (2006) (51)
- IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis. (2000) (51)
- A model of pulmonary atelectasis in rats: activation of alveolar macrophage and cytokine release. (1993) (51)
- L-arginine: a unique amino acid for restoring the depressed macrophage functions after trauma-hemorrhage. (1999) (51)
- Prolactin: a novel and safe immunomodulating hormone for the treatment of immunodepression following severe hemorrhage. (1996) (50)
- Mechanisms of immune resolution. (2003) (50)
- Measurement of circulating blood volume in vivo after trauma-hemorrhage and hemodilution. (1994) (50)
- The role of neutrophils in producing hepatocellular dysfunction during the hyperdynamic stage of sepsis in rats. (1997) (50)
- Effect of surgical trauma on splenocyte and peritoneal macrophage immune function. (1995) (49)
- Differential cellular immunolocalization of renal tumour necrosis factor‐α production during ischaemia versus endotoxaemia (2001) (48)
- Does Fas ligand or endotoxin contribute to thymic apoptosis during polymicrobial sepsis? (1999) (48)
- Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury. (2002) (48)
- Sepsis-induced changes in macrophage co-stimulatory molecule expression: CD86 as a regulator of anti-inflammatory IL-10 response. (2004) (47)
- CXC CHEMOKINE SUPPRESSION OF POLYMORPHONUCLEAR LEUKOCYTES APOPTOSIS AND PRESERVATION OF FUNCTION IS OXIDATIVE STRESS INDEPENDENT (2000) (47)
- Factors responsible for peritoneal granulocyte apoptosis during sepsis. (1997) (46)
- Melatonin Administration Attenuates Depressed Immune Functions after Trauma-Hemorrhage (1996) (46)
- Programmed Death 1 Expression as a Marker for Immune and Physiological Dysfunction in the Critically Ill Surgical Patient (2012) (45)
- Neutrophils regulate their own apoptosis via preservation of CXC receptors. (2000) (45)
- Mechanisms of Indirect Acute Lung Injury: A Novel Role for the Coinhibitory Receptor, Programmed Death-1 (2012) (44)
- Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated. (2001) (43)
- Adequate crystalloid resuscitation restores but fails to maintain the active hepatocellular function following hemorrhagic shock. (1990) (43)
- Anti-TNF monoclonal antibodies prevent haemorrhage-induced suppression of Kupffer cell antigen presentation and MHC class II antigen expression. (1991) (43)
- Immune suppression in polymicrobial sepsis: differential regulation of Th1 and Th2 responses by p38 MAPK. (2000) (43)
- Mechanism of immunosuppression following hemorrhage: defective antigen presentation by macrophages. (1989) (43)
- Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice. (2010) (42)
- Inhibition of CD1d activation suppresses septic mortality: a role for NK-T cells in septic immune dysfunction. (2003) (42)
- Human myocardial tissue TNFalpha expression following acute global ischemia in vivo. (1998) (42)
- Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand‐1 (2013) (42)
- Effects of prolactin and metoclopramide on macrophage cytokine gene expression in late sepsis. (1997) (41)
- Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (2018) (39)
- Protective effects of preheparinization on the microvasculature during and after hemorrhagic shock. (1992) (39)
- CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis (2009) (39)
- Part II: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints. (2019) (39)
- Neutrophil-endothelial interactions mediate angiopoietin-2-associated pulmonary endothelial cell dysfunction in indirect acute lung injury in mice. (2013) (38)
- Energetics of lymphocyte "burnout" in late sepsis: adjuvant treatment with ATP-MgCl2 improves energetics and decreases lethality. (1994) (38)
- Deficiency of gammadelta T lymphocytes contributes to mortality and immunosuppression in sepsis. (2006) (38)
- Hypoxemia in the absence of blood loss upregulates iNOS expression and activity in macrophages. (1999) (38)
- Platelet activating factor and its role in trauma, shock, and sepsis. (1996) (37)
- Immune function is more compromised after closed bone fracture and hemorrhagic shock than hemorrhage alone. (1996) (37)
- Sepsis‐induced SOCS‐3 expression is immunologically restricted to phagocytes (2003) (37)
- Metoclopramide: a novel and safe immunomodulating agent for restoring the depressed macrophage immune function after hemorrhage. (1998) (37)
- Inducible macrophage apoptosis following sepsis is mediated by cysteine protease activation and nitric oxide release. (1997) (36)
- Sepsis induces increased apoptosis in lamina propria mononuclear cells which is associated with altered cytokine gene expression. (1998) (36)
- Association between decreased splenic ATP levels and immunodepression: amelioration with ATP-MgCl2. (1991) (36)
- Inhibition of neutrophil Apoptosis after severe trauma is NFκβ dependent. Discussion (2000) (35)
- TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary acute lung injury (2015) (35)
- Trauma-hemorrhage induces increased thymic apoptosis while decreasing IL-3 release and increasing GM-CSF. (1997) (34)
- Chloroquine inhibits macrophage tumour necrosis factor-alpha mRNA transcription. (1993) (34)
- Premise for Standardized Sepsis Models. (2019) (34)
- Enhanced Innate Inflammation Induced by Anti-BTLA Antibody in Dual Insult Model of Hemorrhagic Shock/Sepsis (2016) (34)
- Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury* (2010) (34)
- Sepsis induces an early increased spontaneous release of hepatocellular stimulatory factor (interleukin-6) by Kupffer cells in both endotoxin tolerant and intolerant mice. (1992) (34)
- Biliary obstruction results in PD‐1‐dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils (2013) (33)
- Immune consequences of hypovolemic shock and resuscitation (1993) (33)
- Beneficial versus detrimental effects of neutrophils are determined by the nature of the insult. (2007) (33)
- Do different rates of fluid resuscitation adversely or beneficially influence immune responses after trauma-hemorrhage? (1998) (33)
- Insight into the mechanism by which metoclopramide improves immune functions after trauma-hemorrhage. (2000) (32)
- Testosterone: the culprit for producing splenocyte immune depression after trauma hemorrhage. (1998) (32)
- Neither Fas ligand nor endotoxin is responsible for inducible peritoneal phagocyte apoptosis during sepsis/peritonitis. (2000) (32)
- The Role and Source of Tumor Necrosis Factor-&agr; in Hemorrhage-Induced Priming for Septic Lung Injury (2012) (32)
- Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130. (2013) (32)
- Dietary n-3 polyunsaturated fatty acid modulation of immune cell function before or after trauma. (1995) (32)
- Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD‐1 (2014) (31)
- Fate and effects of adult bone marrow cells in lungs of normoxic and hyperoxic newborn mice. (2009) (31)
- Chloroquine attenuates hemorrhagic shock-induced immunosuppression and decreases susceptibility to sepsis. (1992) (30)
- Splenic immune suppression in sepsis: A role for IL-10-induced changes in P38 MAPK signaling. (1999) (29)
- Peritoneal macrophages show increased cytokine gene expression following haemorrhagic shock. (1994) (29)
- CD28 homodimer interface mimetic peptide acts as a preventive and therapeutic agent in models of severe bacterial sepsis and gram-negative bacterial peritonitis. (2015) (29)
- Hepatocellular dysfunction persists during early sepsis despite increased volume of crystalloid resuscitation. (1991) (29)
- Mechanism of immune dysfunction in sepsis: inducible nitric oxide-meditated alterations in p38 MAPK activation. (2002) (29)
- Novel Role for PD-1:PD-L1 as Mediator of Pulmonary Vascular Endothelial Cell Functions in Pathogenesis of Indirect ARDS in Mice (2018) (29)
- NF-&kgr;B ACTIVATION HAS TISSUE-SPECIFIC EFFECTS ON IMMUNE CELL APOPTOSIS DURING POLYMICROBIAL SEPSIS (2002) (28)
- l-Arginine attenuates trauma-hemorrhage-induced liver injury (2000) (28)
- Rat and Mouse Models of Hypovolemic-Traumatic Shock (1993) (28)
- Programmed Cell Death Receptor Ligand 1 Modulates the Regulatory T Cells’ Capacity to Repress Shock/Sepsis–Induced Indirect Acute Lung Injury by Recruiting Phosphatase Src Homology Region 2 Domain-Containing Phosphatase 1 (2015) (28)
- Does hepatocellular injury in sepsis involve apoptosis? (1998) (28)
- Genetic disruption of protein kinase Cδ reduces endotoxin-induced lung injury. (2012) (27)
- The Dual Functions of Receptor Interacting Protein 1 in Fas-Induced Hepatocyte Death During Sepsis (2011) (27)
- A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis (2018) (27)
- ATP-MgCl2 restores renal microcirculation following trauma and severe hemorrhage. (1992) (27)
- Changes in dendritic cell function in the immune response to sepsis (2007) (27)
- On-pump coronary artery bypass surgery activates human myocardial NF-κB and increases TNF-α in the heart (2003) (27)
- Prolactin inhibits the increased cytokine gene expression in Kupffer cells following haemorrhage. (1996) (27)
- Does endotoxin play a major role in inducing the depression of macrophage function during polymicrobial sepsis? (1995) (27)
- Paracrine Suppression of Apoptosis by Cytokine-Stimulated Neutrophils Involves Divergent Regulation Of NF-&Kgr;B, Bcl-XL, and Bak (2002) (26)
- Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis. (2007) (26)
- Fas-Ligand Mediated Apoptosis in Severe Sepsis and Shock (2003) (26)
- Role of protein kinase C in cyclic AMP-mediated suppression of T-lymphocyte activation following burn injury. (1999) (25)
- TRAUMA‐HEMORRHAGE ACTIVATES SIGNAL TRANSDUCTION PATHWAYS IN MOUSE SPLENIC T CELLS (1998) (25)
- Pentoxifylline attenuates oxygen-induced lung injury. (1994) (25)
- Immunoprotective effect of a calcium channel blocker on macrophage antigen presentation function, major histocompatability class II antigen expression, and interleukin-1 synthesis after hemorrhage. (1990) (25)
- Double-hit mouse model of cigarette smoke priming for acute lung injury. (2017) (25)
- Energetics of defective macrophage antigen presentation after hemorrhage as determined by ultraresolution 31P nuclear magnetic resonance spectrometry: restoration with adenosine triphosphate-MgCl2. (1992) (25)
- Chemically induced hypotension increases PGE2 release and depresses macrophage antigen presentation. (1993) (25)
- Soluble programmed cell death receptor-1 (sPD-1): a potential biomarker with anti-inflammatory properties in human and experimental acute respiratory distress syndrome (ARDS) (2016) (24)
- Hemorrhage decreases macrophage inflammatory protein 2 and interleukin-6 release: a possible mechanism for increased wound infection. (1999) (24)
- Inflammatory Mechanisms in Sepsis: Elevated Invariant Natural Killer T-Cell Numbers in Mouse and Their Modulatory Effect on Macrophage Function (2013) (24)
- Improved survival after induction of sepsis by cecal slurry in PD‐1 knockout murine neonates (2017) (24)
- DEFICIENCY OF BID PROTEIN REDUCES SEPSIS-INDUCED APOPTOSIS AND INFLAMMATION, WHILE IMPROVING SEPTIC SURVIVAL (2010) (23)
- Mechanism of diltiazem's immunomodulatory effects after hemorrhage and resuscitation. (1993) (23)
- SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis (2007) (23)
- Check Point Inhibitors and Their Role in Immunosuppression in Sepsis. (2020) (22)
- Depressed osteoblast activity and increased osteocyte necrosis after closed bone fracture and hemorrhagic shock. (1996) (22)
- Rodent Models of Endotoxemia and Sepsis (1993) (22)
- Alterations in Inflammatory Cytokine Production Following Hemorrhage and Resuscitation (1993) (21)
- The role and regulation of apoptosis in sepsis (2005) (21)
- A Novel Role for Programmed Cell Death Receptor Ligand-1 in Sepsis-Induced Intestinal Dysfunction (2016) (21)
- ACTIVATION OF COMMON ANTIVIRAL PATHWAYS CAN POTENTIATE INFLAMMATORY RESPONSES TO SEPTIC SHOCK (2006) (21)
- Effect of Exposure Period and Algal Concentration on the Frequency of Infection of Aposymbiotic Ciliates by Symbiotic Algae from Paramecium bursaria (1979) (21)
- Insights into the role of gammadelta T lymphocytes in the immunopathogenic response to thermal injury. (2000) (21)
- Sepsis-Induced Potentiation of Peritoneal Macrophage Migration Is Mitigated by Programmed Cell Death Receptor-1 Gene Deficiency (2013) (20)
- Eicosanoids regulate tumor necrosis factor synthesis after hemorrhage in vitro and in vivo. (1991) (20)
- Blockade of Endothelial Growth Factor, Angiopoietin-2, Reduces Indices of Ards and Mortality in Mice Resulting from the Dual-Insults of Hemorrhagic Shock and Sepsis (2016) (20)
- Divergent roles of murine neutrophil chemokines in hemorrhage induced priming for acute lung injury. (2005) (20)
- A divergent response of innate regulatory T-cells to sepsis in humans: circulating invariant natural killer T-cells are preserved. (2014) (20)
- IL-1beta stimulation induces paracrine regulation of PMN function and apoptosis. (1999) (19)
- Improved Antimicrobial Host Defense in Mice following Poly-(1,6)-β-d-Glucopyranosyl-(1,3)-β-d-Glucopyranose Glucan Treatment by a Gender-Dependent Immune Mechanism (2011) (18)
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- THE ROLE OF MYD88-INDEPENDENT, TRIF PATHWAY IN POLYMICROBIAL SEPSIS (2006) (0)
- HEMORRHAGIC SHOCK INDUCES DIFFERENTIAL EXPRESSION OF SOCS-1 AND SOCS-3 PROTEINS (2006) (0)
- SEPTIC MUCOSAL INTRAEPITHELIAL LYMPHOID IMMUNE SUPPRESSION IS NOT IL-10 MEDIATED (1999) (0)
- Lymphocytes From Septic Geriatric Patients Display Functional Exhaustion (2013) (0)
- CELL INJURY , REPAIR , AGING , AND APOPTOSIS Kupffer Cells Protect Liver Sinusoidal Endothelial Cells from Fas-Dependent Apoptosis in Sepsis by Down-Regulating gp 130 (2013) (0)
- Editorial Board Acknowledgment. (2017) (0)
- CIRCULATING OXIDIZED LDLS ARE ASSOCIATED WITH IMMUNE RESPONSIVENESS IN SYSTEMIC INFLAMMATION: 577 (2004) (0)
- Norepinephine Administration In Patients For Septic Shock Induces Th2 Cytokine Expression In Blood (2011) (0)
- Application of single cell multiomics points to changes in chromatin accessibility near calcitonin receptor like receptor and a possible role for adrenomedullin in the post-shock lung (2023) (0)
- Migrating Invariant Natural Killer T-Cells Modulate Chemokine Receptor Expression in Response to Polymicrobial Sepsis (2014) (0)
- EICANOSOIDS REGULATE TUMOR NECROSIS FACTOR (TNF) SYNTHESIS FOLLOWING HEMORRHAGE IN VITRO AND IN VIVO (1990) (0)
- Cigarette smoke and Pseudomonas aeruginosa synergistically cause ARDS via impairment of mitophagic flux and NLRP3 inflammasome activation (2019) (0)
- REQUIREMENT FOR PI3K AND MEK‐I IN THE PARACRINE SUPPRESSION OF NEUTROPHIL (PMN) CHEMOTAXIS BY TNF‐&agr;‐STIMULATED PMN.: 222 (2001) (0)
- Indirect Acute Lung Injury after Intra-Abdominal Sepsis in Murine Neonates Is Mediated by Programmed Cell Death Receptor-1’s Effects on Innate Immune Cells (2017) (0)
- Clinical Manifestion Sepsis and Nitric Oxide Level on Mice Induced by Lipopolysaccharide (2013) (0)
- PMN Depletion Alters Ang‐1:Ang‐2 & Increases Tie2 Phosphorylation Following Hemorrhagic Shock Priming for the Development of iARDS in Mice (2015) (0)
- BLOCKADE OF TLR‐NFkB SIGNALING DOWNREGULATE SOCS‐3 EXPRESSION DURING SEPSIS.: 237 (2004) (0)
- Suppressor of cytokine signaling (SOCS)‐1 but not SOCS‐3 inhibits MCP‐1 production in mouse lung epithelial cells (2008) (0)
- The Protective Role Of Protein Kinase Cd (PKCd) In LPS-Induced Pulmonary Edema (2012) (0)
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