Alfred L. Goldberg

Alfred L. Goldberg's AcademicInfluence.com Rankings

Alfred L. Goldberg

Biology

#1655

World Rank

#2711

Historical Rank

#802

USA Rank

Cell Biology

#29

World Rank

#33

Historical Rank

#15

USA Rank

Biochemistry

#132

World Rank

#168

Historical Rank

#73

USA Rank

biology Degrees

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Biology

Alfred L. Goldberg's Degrees

Masters Biochemistry Stanford University

Why Is Alfred L. Goldberg Influential?

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According to Wikipedia, Alfred Lewis Goldberg was an American cell biologist-biochemist and professor at Harvard University. His major discoveries have concerned the mechanisms and physiological importance of protein degradation in cells. Of wide impact have been his lab's demonstration that all cells contain a pathway for selectively eliminating misfolded proteins, his discoveries about the role of proteasomes in this process and of the enzyme systems catalyzing protein breakdown in bacteria, his elucidating the mechanisms for muscle atrophy and the role of proteasomes in antigen presentation to the immune system, and his introduction of proteasome inhibitors now widely used as research tools and in the treatment of blood cancers.

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Alfred L. Goldberg's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy (2004) (2629)
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules (1994) (2565)
Structure and functions of the 20S and 26S proteasomes. (1996) (2460)
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008) (2360)
Protein degradation and protection against misfolded or damaged proteins (2003) (2022)
The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB (1994) (1907)
FoxO3 controls autophagy in skeletal muscle in vivo. (2007) (1744)
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy (2001) (1691)
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression (2004) (1484)
Proteasome inhibitors: valuable new tools for cell biologists. (1998) (1478)
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. (2007) (1403)
Intracellular protein degradation in mammalian and bacterial cells. (1974) (1205)
Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. (1996) (1172)
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. (2006) (1088)
Proteasome inhibitors: from research tools to drug candidates. (2001) (1086)
Cellular Defenses against Unfolded Proteins A Cell Biologist Thinks about Neurodegenerative Diseases (2001) (1025)
Degradation of cell proteins and the generation of MHC class I-presented peptides. (1999) (967)
PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription (2006) (921)
Multiple proteolytic systems, including the proteasome, contribute to CFTR processing (1995) (914)
Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes. (1986) (904)
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival (2010) (814)
Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. (1975) (810)
Muscle wasting in disease: molecular mechanisms and promising therapies (2014) (726)
Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. (1999) (724)
The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes (1999) (614)
IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. (2004) (614)
Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever. (1983) (612)
Trehalose Accumulation during Cellular Stress Protects Cells and Cellular Proteins from Damage by Oxygen Radicals* (2001) (610)
γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes (1993) (602)
An IFN-γ–induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I–presented peptides (2002) (587)
Proteolysis, proteasomes and antigen presentation (1992) (583)
During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation (2009) (573)
Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases (2007) (563)
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. (1994) (542)
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues (2002) (539)
The Logic of the 26S Proteasome (2017) (539)
Production of abnormal proteins in E. coli stimulates transcription of ion and other heat shock genes (1985) (506)
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. (2007) (484)
Proteasome Inhibition Leads to a Heat-shock Response, Induction of Endoplasmic Reticulum Chaperones, and Thermotolerance* (1997) (482)
Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy (2015) (482)
Altered peptidase and viral-specific T cell response in LMP2 mutant mice. (1994) (481)
Certain Pairs of Ubiquitin-conjugating Enzymes (E2s) and Ubiquitin-Protein Ligases (E3s) Synthesize Nondegradable Forked Ubiquitin Chains Containing All Possible Isopeptide Linkages* (2007) (477)
A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes. (1977) (444)
Importance of the ATP-Ubiquitin-Proteasome Pathway in the Degradation of Soluble and Myofibrillar Proteins in Rabbit Muscle Extracts* (1996) (442)
What do we really know about the ubiquitin-proteasome pathway in muscle atrophy? (2001) (432)
Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. (2004) (426)
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors. (1997) (426)
Mechanism of work-induced hypertrophy of skeletal muscle. (1975) (420)
The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release. (2001) (413)
Lactacystin and clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation* (1997) (409)
Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes. (1994) (409)
The mechanism and functions of ATP-dependent proteases in bacterial and animal cells. (1992) (407)
Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle? (1982) (404)
Oxygen radicals stimulate intracellular proteolysis and lipid peroxidation by independent mechanisms in erythrocytes. (1987) (403)
Selective Inhibitors of the Proteasome-dependent and Vacuolar Pathways of Protein Degradation in Saccharomyces cerevisiae * (1996) (394)
Importance of the Different Proteolytic Sites of the Proteasome and the Efficacy of Inhibitors Varies with the Protein Substrate* (2006) (392)
Identity of the 19S 'prosome' particle with the large multifunctional protease complex of mammalian cells (the proteasome) (1988) (370)
BMP signaling controls muscle mass (2013) (370)
26S proteasomes and immunoproteasomes produce mainly N‐extended versions of an antigenic peptide (2001) (364)
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. (2008) (361)
Protein degradation and the generation of MHC class I-presented peptides. (2002) (355)
Trehalose synthesis is induced upon exposure of Escherichia coli to cold and is essential for viability at low temperatures (2002) (352)
The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides. (2002) (352)
Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting. (1993) (349)
Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy. (2007) (340)
Patterns of gene expression in atrophying skeletal muscles: response to food deprivation (2002) (335)
PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone (2000) (333)
A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentation (1993) (330)
Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles. (1997) (328)
Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates. (2005) (325)
Intracellular protein degradation in mammalian and bacterial cells: Part 2. (1976) (324)
Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase* (1998) (324)
Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7. (1994) (324)
The FOXO3a Transcription Factor Regulates Cardiac Myocyte Size Downstream of AKT Signaling* (2005) (322)
Proteasomes play an essential role in thymocyte apoptosis. (1996) (320)
Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling (2015) (320)
The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. (2005) (319)
Functions of the proteasome: the lysis at the end of the tunnel. (1995) (316)
mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy (2015) (316)
Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cells. (1987) (308)
The Degradation of Apolipoprotein B100 Is Mediated by the Ubiquitin-proteasome Pathway and Involves Heat Shock Protein 70* (1997) (304)
Post-proteasomal antigen processing for major histocompatibility complex class I presentation (2004) (303)
Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy. (1990) (299)
Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide. (1997) (297)
The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors. (1987) (294)
Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy. (1995) (291)
Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown. (1999) (282)
The product of the lon (capR) gene in Escherichia coli is the ATP-dependent protease, protease La. (1981) (281)
Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. (2014) (278)
The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins. (1990) (276)
Origin and possible significance of alanine production by skeletal muscle. (1974) (274)
Protein turnover in skeletal muscle. II. Effects of denervation and cortisone on protein catabolism in skeletal muscle. (1969) (273)
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. (2005) (272)
Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma. (1995) (269)
A high molecular weight protease in the cytosol of rat liver. I. Purification, enzymological properties, and tissue distribution. (1986) (264)
Effects of food deprivation on protein synthesis and degradation in rat skeletal muscles. (1976) (264)
Arachidonic acid, prostaglandin E2 and F2 alpha influence rates of protein turnover in skeletal and cardiac muscle. (1982) (263)
A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily. (1994) (260)
ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation. (2003) (258)
Degradation of Abnormal Proteins in Escherichia coli (1972) (256)
Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis (2013) (251)
Regulation and significance of amino acid metabolism in skeletal muscle. (1978) (249)
Development of proteasome inhibitors as research tools and cancer drugs (2012) (249)
Proteolysis and class I major histocompatibility complex antigen presentation (1999) (247)
Proteins are unfolded on the surface of the ATPase ring before transport into the proteasome. (2001) (243)
Why do cellular proteins linked to K63‐polyubiquitin chains not associate with proteasomes? (2013) (238)
Proteasome Inhibitors Cause Induction of Heat Shock Proteins and Trehalose, Which Together Confer Thermotolerance inSaccharomyces cerevisiae (1998) (237)
Myostatin/activin pathway antagonism: molecular basis and therapeutic potential. (2013) (235)
Hormonal regulation of protein degradation and synthesis in skeletal muscle. (1980) (235)
Leupeptin, a protease inhibitor, decreases protein degradation in normal and diseased muscles. (1978) (234)
Yeast adapt to near-freezing temperatures by STRE/Msn2,4-dependent induction of trehalose synthesis and certain molecular chaperones. (2004) (234)
TNF‐α increases ubiquitin‐conjugating activity in skeletal muscle by up‐regulating UbcH2/E220k (2003) (232)
Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation. (1995) (229)
HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome. (1996) (229)
Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes (2002) (226)
Hepatitis B Virus X Protein Is both a Substrate and a Potential Inhibitor of the Proteasome Complex (1999) (224)
hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37 (2006) (218)
Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening. (2009) (217)
Work-induced growth of skeletal muscle in normal and hypophysectomized rats. (1967) (217)
Range of Sizes of Peptide Products Generated during Degradation of Different Proteins by Archaeal Proteasomes* (1998) (212)
Processive Degradation of Proteins and Other Catalytic Properties of the Proteasome from Thermoplasma acidophilum* (1997) (210)
Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity. (1993) (209)
Oxidation of leucine by rat skeletal muscle. (1972) (207)
Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models (2013) (207)
Ubiquitin ligase Nedd4 promotes α-synuclein degradation by the endosomal–lysosomal pathway (2011) (206)
Pathway for Degradation of Peptides Generated by Proteasomes (2004) (206)
Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates. (1987) (204)
Structural Basis For Antigenic Peptide Precursor Processing by the Endoplasmic Reticulum Aminopeptidase ERAP1 (2011) (203)
Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway* (2010) (196)
Endocrine regulation of protein breakdown in skeletal muscle. (1988) (195)
Cancer Vulnerabilities Unveiled by Genomic Loss (2012) (195)
Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy* (2010) (194)
The metabolic fates of amino acids and the formation of glutamine in skeletal muscle. (1978) (193)
The ATP-dependent HslVU protease from Escherichia coli is a four-ring structure resembling the proteasome (1997) (190)
Oxidation of amino acids by diaphragms from fed and fasted rats. (1972) (190)
Heat shock regulatory gene htpR influences rates of protein degradation and expression of the lon gene in Escherichia coli. (1984) (189)
ATP Binds to Proteasomal ATPases in Pairs with Distinct Functional Effects, Implying an Ordered Reaction Cycle (2011) (188)
ATP-dependent protease La (lon) from Escherichia coli. (1994) (187)
Sequence of the lon gene in Escherichia coli. A heat-shock gene which encodes the ATP-dependent protease La. (1988) (185)
Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats. (1999) (184)
Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia (1999) (183)
Involvement of the chaperonin dnaK in the rapid degradation of a mutant protein in Escherichia coli. (1992) (181)
Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97 (2014) (179)
Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins (2008) (177)
An Archaebacterial ATPase, Homologous to ATPases in the Eukaryotic 26 S Proteasome, Activates Protein Breakdown by 20 S Proteasomes* (1999) (177)
Proteasome Subunits X and Y Alter Peptidase Activities in Opposite Ways to the Interferon-γ-induced Subunits LMP2 and LMP7* (1996) (176)
Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy (2012) (176)
Trigger factor is induced upon cold shock and enhances viability of Escherichia coli at low temperatures. (1997) (175)
cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins (2015) (175)
Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides. (1999) (175)
The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites* (2003) (173)
Relationship between cortisone and muscle work in determining muscle size (1969) (170)
The origin of alanine produced in skeletal muscle. (1978) (170)
Binding of Hydrophobic Peptides to Several Non-catalytic Sites Promotes Peptide Hydrolysis by All Active Sites of 20 S Proteasomes (2002) (168)
Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome (1996) (166)
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. (2009) (165)
The influence of skeletal muscle on systemic aging and lifespan (2013) (165)
Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection (2012) (165)
Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKM z (2009) (165)
Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor (2008) (165)
Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3 (2002) (164)
The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. (2003) (162)
ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation. (2010) (162)
Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae (1996) (161)
The heat-shock protein ClpB in Escherichia coli is a protein-activated ATPase. (1992) (161)
Rate of antigen degradation by the ubiquitin-proteasome pathway influences MHC class I presentation. (1995) (158)
Major Histocompatibility Complex Class I-presented Antigenic Peptides Are Degraded in Cytosolic Extracts Primarily by Thimet Oligopeptidase* (2001) (158)
Protease Ti, a new ATP-dependent protease in Escherichia coli, contains protein-activated ATPase and proteolytic functions in distinct subunits. (1988) (154)
Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway. (1998) (154)
The stimulation of protein degradation in muscle by Ca2+ is mediated by prostaglandin E2 and does not require the calcium-activated protease. (1982) (153)
SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth* (2013) (153)
Identification of a Novel Pool of Extracellular Pro-myostatin in Skeletal Muscle* (2008) (147)
JunB transcription factor maintains skeletal muscle mass and promotes hypertrophy (2010) (146)
New insights into the mechanisms and importance of the proteasome in intracellular protein degradation. (1997) (145)
Inhibition of ubiquitin-proteasome pathway–mediated IκBα degradation by a naturally occurring antibacterial peptide (2000) (145)
Protein turnover in skeletal muscle. I. Protein catabolism during work-induced hypertrophy and growth induced with growth hormone. (1969) (144)
Proteins containing peptide sequences related to Lys-Phe-Glu-Arg-Gln are selectively depleted in liver and heart, but not skeletal muscle, of fasted rats. (1991) (143)
PROTEIN SYNTHESIS DURING WORK-INDUCED GROWTH OF SKELETAL MUSCLE (1968) (142)
Autoubiquitination of the 26S Proteasome on Rpn13 Regulates Breakdown of Ubiquitin Conjugates (2014) (142)
New insights into proteasome function: from archaebacteria to drug development. (1995) (142)
Maintenance of normal length improves protein balance and energy status in isolated rat skeletal muscles. (1986) (140)
Relationship between in vivo degradative rates and isoelectric points of proteins. (1975) (139)
The N-end Rule Pathway Catalyzes a Major Fraction of the Protein Degradation in Skeletal Muscle* (1998) (139)
Thyroid hormones control lysosomal enzyme activities in liver and skeletal muscle. (1978) (138)
Nrdp1‐mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis (2004) (135)
Rapid degradation of an abnormal protein in Escherichia coli involves the chaperones GroEL and GroES. (1994) (133)
Involvement of the proteasome in various degradative processes in mammalian cells. (1989) (128)
Activation of protein breakdown and prostaglandin E2 production in rat skeletal muscle in fever is signaled by a macrophage product distinct from interleukin 1 or other known monokines. (1988) (128)
Characterization of the Brain 26S Proteasome and its Interacting Proteins (2010) (128)
TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k. (2003) (127)
ATP serves two distinct roles in protein degradation in reticulocytes, one requiring and one independent of ubiquitin (1983) (126)
Activation of the ubiquitin-ATP-dependent proteolytic system in skeletal muscle during fasting and denervation atrophy. (1991) (125)
Why Does Threonine, and Not Serine, Function as the Active Site Nucleophile in Proteasomes?* (2000) (124)
Degradation of abnormal proteins in Escherichia coli. Formation of protein inclusions in cells exposed to amino acid analogs. (1975) (123)
Escherichia coli contains a soluble ATP-dependent protease (Ti) distinct from protease La. (1987) (123)
An increased content of protease La, the lon gene product, increases protein degradation and blocks growth in Escherichia coli. (1987) (123)
E. coli contains eight soluble proteolytic activities, one being ATP dependent (1981) (123)
Purification from Escherichia coli of a periplasmic protein that is a potent inhibitor of pancreatic proteases. (1983) (122)
The effect of protease inhibitors and decreased temperature on the degradation of different classes of proteins in cultured hepatocytes (1979) (121)
Leucine degradation in cell-free extracts of skeletal muscle. (1979) (120)
Purification and Characterization of the Heat Shock Proteins HslV and HslU That Form a New ATP-dependent Protease in Escherichia coli* (1996) (120)
The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism. (1986) (119)
Skeletal muscle and liver contain a soluble ATP + ubiquitin-dependent proteolytic system. (1987) (118)
The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring (2012) (118)
The ATP Costs and Time Required to Degrade Ubiquitinated Proteins by the 26 S Proteasome* (2013) (117)
Proteasomes and their associated ATPases: a destructive combination. (2006) (116)
The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo (2014) (115)
Protein Synthesis in Tonic and Phasic Skeletal Muscles (1967) (115)
Role of different proteolytic pathways in degradation of muscle protein from streptozotocin-diabetic rats. (1996) (114)
Protease Ti from Escherichia coli requires ATP hydrolysis for protein breakdown but not for hydrolysis of small peptides. (1989) (110)
Ca2+-free Calmodulin and Calmodulin Damaged byin Vitro Aging Are Selectively Degraded by 26 S Proteasomes without Ubiquitination* (2000) (108)
Red blood cells contain a pathway for the degradation of oxidant-damaged hemoglobin that does not require ATP or ubiquitin. (1986) (108)
Interactions of PAN's C‐termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactions (2010) (108)
Tripeptidyl Peptidase II Is the Major Peptidase Needed to Trim Long Antigenic Precursors, but Is Not Required for Most MHC Class I Antigen Presentation1 (2006) (108)
Ubiquitinated Proteins Activate the Proteasomal ATPases by Binding to Usp14 or Uch37 Homologs* (2013) (108)
Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue. (1988) (107)
The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts. (1985) (106)
Trigger factor is involved in GroEL‐dependent protein degradation in Escherichia coli and promotes binding of GroEL to unfolded proteins. (1995) (106)
Identification and partial purification of an ATP-stimulated alkaline protease in rat liver. (1979) (105)
Structural characterization of the interaction of Ubp6 with the 26S proteasome (2015) (104)
The Internal Sequence of the Peptide-Substrate Determines Its N-Terminus Trimming by ERAP1 (2008) (103)
A Conserved F Box Regulatory Complex Controls Proteasome Activity in Drosophila (2011) (103)
Newly synthesized proteins are degraded by an ATP‐stimulated proteolytic process in isolated pea chloroplasts (1984) (102)
The Membrane-associated Inhibitor of Apoptosis Protein, BRUCE/Apollon, Antagonizes Both the Precursor and Mature Forms of Smac and Caspase-9* (2005) (102)
Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins (2013) (100)
In vitro preparations of the diaphragm and other skeletal muscles. (1975) (99)
Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria. (1982) (99)
Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry (2011) (99)
Heat shock in Escherichia coli alters the protein-binding properties of the chaperonin groEL by inducing its phosphorylation (1992) (97)
Selectivity of intracellular proteolysis: protein substrates activate the ATP-dependent protease (La). (1986) (96)
Subcellular distribution of various proteases in Escherichia coli (1982) (96)
Not just research tools—proteasome inhibitors offer therapeutic promise (2002) (95)
The unfolding of substrates and ubiquitin-independent protein degradation by proteasomes. (2001) (94)
Effects of protease inhibitors on protein breakdown in Escherichia coli. (1972) (94)
Degradation of the acetylcholine receptor in cultured muscle cells: Selective inhibitors and the fate of undegraded receptors (1980) (93)
Gamma‐interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages (1995) (93)
Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease (2016) (93)
Protease La from Escherichia coli hydrolyzes ATP and proteins in a linked fashion. (1982) (91)
Bacterial proteolytic complexes as therapeutic targets (2012) (90)
S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains (2009) (89)
c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. (2007) (88)
Protease La, the lon gene product, cleaves specific fluorogenic peptides in an ATP-dependent reaction. (1985) (86)
A high molecular weight metalloendoprotease from the cytosol of mammalian cells. (1983) (85)
Intermediate steps in the degradation of a specific abnormal protein in Escherichia coli. (1977) (85)
Liver mitochondria contain an ATP-dependent, vanadate-sensitive pathway for the degradation of proteins. (1982) (84)
A statistical analysis of the relationship between degradative rates and molecular weights of proteins. (1975) (84)
Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide. (2000) (84)
Puromycin‐sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation (2007) (82)
Trigger Factor Associates with GroEL in Vivo and Promotes Its Binding to Certain Polypeptides* (1997) (82)
Involvement of molecular chaperones in intracellular protein breakdown. (1996) (82)
LEUCINE OXIDATION IN BRAIN SLICES AND NERVE ENDINGS 1 (1976) (81)
Blm10 Protein Promotes Proteasomal Substrate Turnover by an Active Gating Mechanism* (2011) (81)
Oxidized proteins in erythrocytes are rapidly degraded by the adenosine triphosphate-dependent proteolytic system. (1982) (79)
Getting to First Base in Proteasome Assembly (2009) (79)
Leucine inhibits oxidation of glucose and pyruvate in skeletal muscles during fasting. (1978) (79)
Regulating protein breakdown through proteasome phosphorylation. (2017) (78)
Re-examining class-I presentation and the DRiP hypothesis. (2014) (77)
Energy requirement for degradation of tumor-associated protein p53 (1984) (77)
Proteases in Escherichia coli. (1993) (76)
Enzymes Catalyzing Ubiquitination and Proteolytic Processing of the p105 Precursor of Nuclear Factor κB1* (1998) (76)
Skeletal muscle proteasome can degrade proteins in an ATP-dependent process that does not require ubiquitin. (1989) (75)
Evidence that the intracellular pool of tyrosine serves as precursor for protein synthesis in muscle. (1973) (74)
The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation (1996) (74)
Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation. (2017) (73)
The role of ATP hydrolysis in the breakdown of proteins and peptides by protease La from Escherichia coli. (1985) (72)
Protein substrates activate the ATP-dependent protease La by promoting nucleotide binding and release of bound ADP. (1987) (72)
The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins (2012) (71)
Amino acid transport during work-induced growth of skeletal muscle. (1969) (71)
DNA stimulates ATP-dependent proteolysis and protein-dependent ATPase activity of protease La from Escherichia coli. (1982) (70)
Control of protein degradation in muscle by prostaglandins, Ca2+, and leukocytic pyrogen (interleukin 1). (1984) (70)
Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy (2010) (69)
[50] Proteases in Escherichia coli (1981) (69)
26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation (2019) (69)
Heat shock of Escherichia coli increases binding of dnaK (the hsp70 homolog) to polypeptides by promoting its phosphorylation. (1993) (68)
Leucine degradation and release of glutamine and alanine by adipose tissue. (1980) (68)
Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation (2014) (68)
Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease (2014) (66)
Influence of food deprivation and adrenal steroids on DNA synthesis in various mammalian tissues. (1975) (66)
Influence of pituitary growth hormone on DNA synthesis in rat tissues. (1975) (66)
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease (2016) (65)
Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome (2015) (63)
Suppression of muscle protein turnover and amino acid degradation by dietary protein deficiency. (1992) (62)
The Molecular Chaperone DnaJ Is Required for the Degradation of a Soluble Abnormal Protein in Escherichia coli * (2001) (62)
Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation (2018) (62)
Structural and functional effects of PA700 and modulator protein on proteasomes. (1997) (62)
Influence of Insulin and Contractile Activity on Muscle Size and Protein Balance (1979) (61)
A serine protease activity in C3H/10T1/2 cells that is inhibited by anticarcinogenic protease inhibitors. (1987) (61)
Inhibitors of protein and RNA synthesis cause a rapid block in prostaglandin production at the prostaglandin synthase step. (1986) (59)
Correlation between rates of degradation of bacterial proteins in vivo and their sensitivity to proteases. (1972) (57)
The direction of protein entry into the proteasome determines the variety of products and depends on the force needed to unfold its two termini. (2012) (56)
The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis (2017) (55)
The Ubiquitin-interacting Motif Protein, S5a, Is Ubiquitinated by All Types of Ubiquitin Ligases by a Mechanism Different from Typical Substrate Recognition* (2009) (55)
Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c (2017) (55)
Control of proteasomal proteolysis by mTOR (2016) (54)
Influence of calcium and other divalent cations on protein turnover in rat skeletal muscle. (1986) (54)
Problems in the use of (Me- 3H) thymidine for the measurement of DNA synthesis. (1973) (54)
Protein degradation is stimulated by ATP in extracts of Escherichia coli. (1979) (53)
The heat-shock protein HslVU from Escherichia coli is a protein-activated ATPase as well as an ATP-dependent proteinase. (1997) (53)
Role of proteasomes in antigen presentation. (1993) (52)
The proteasome subunit, C2, contains an important site for binding of the PA28 (11S) activator. (1996) (51)
The energy utilized in protein breakdown by the ATP-dependent protease (La) from Escherichia coli. (1987) (50)
Studies of the ATP-dependent proteolytic enzyme, protease La, from Escherichia coli. (1982) (50)
Fate of abnormal proteins in E. coli accumulation in intracellular granules before catabolism. (1972) (50)
Troponin-like proteins from muscles of the scallop, Aequipecten irradians. (1978) (49)
Control of protein degradation in reticulocytes and reticulocyte extracts by hemin. (1980) (49)
Binding of nucleotides to the ATP-dependent protease La from Escherichia coli. (1987) (49)
UPTAKE AND RELEASE OF 45Ca BY BRAIN MICROSOMES, SYNAPTOSOMES AND SYNAPTIC VESICLES 1, 2 (1971) (48)
A role of aminoacyl-tRNA in the regulation of protein breakdown in Escherichia coli. (1971) (48)
Effects of reduced energy production on protein degradation, guanosine tetraphosphate, and RNA synthesis in Escherichia coli. (1978) (48)
Rapid Degradation of an Abnormal Protein in Escherichia coli Proceeds through Repeated Cycles of Association with GroEL* (1999) (47)
Further evidence for the involvement of charged tRNA and guanosine tetraphosphate in the control of protein degradation in Escherichia coli. (1978) (46)
ATP-induced Structural Transitions in PAN, the Proteasome-regulatory ATPase Complex in Archaea* (2007) (46)
A soluble ATP-dependent system for protein degradation from murine erythroleukemia cells. Evidence for a protease which requires ATP hydrolysis but not ubiquitin. (1985) (46)
Nobel Committee Tags Ubiquitin for Distinction (2005) (45)
Isolation and characterization of protease do from Escherichia coli, a large serine protease containing multiple subunits. (1983) (45)
Coordinate regulation of autophagy and the ubiquitin proteasome system by MTOR (2016) (44)
Studies on the relationship between the degradative rates of proteins in vivo and their isoelectric points. (1979) (44)
PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy (2019) (44)
A new model of cancer cachexia: contribution of the ubiquitin-proteasome pathway. (1999) (43)
Proteolytic Activity of the ATP-dependent Protease HslVU Can Be Uncoupled from ATP Hydrolysis* (1997) (43)
Docking of the Proteasomal ATPases ’ C-termini in the 20 S Proteasomes alpha Ring Opens the Gate for Substrate Entry (2007) (43)
Role of insulin in work-induced growth of skeletal muscle. (1968) (42)
Effects of starvation for potassium and other inorganic ions on protein degradation and ribonucleic acid synthesis in Escherichia coli (1980) (42)
UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells (2018) (42)
Studies of the energy requirement for intracellular protein degradation in Escherichia coli (1978) (42)
Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization (2017) (41)
Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation (2020) (40)
Relationship between growth hormone and muscular work in determining muscle size (1969) (40)
Effects of chymostatin and other proteinase inhibitors on protein breakdown and proteolytic activities in muscle. (1980) (40)
Heat shock-induced phosphorylation of GroEL alters its binding and dissociation from unfolded proteins. (1994) (39)
New insights into the role of the ubiquitin-proteasome pathway in the regulation of apoptosis. (2007) (39)
CHAPTER 9 – The Selective Degradation of Abnormal Proteins in Bacteria (1986) (39)
Role for the adenosine triphosphate-dependent proteolytic pathway in reticulocyte maturation. (1982) (38)
cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases (2020) (38)
Dietary protein deficiency reduces lysosomal and nonlysosomal ATP-dependent proteolysis in muscle. (1992) (37)
Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis* (2016) (37)
Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity* (2015) (37)
Mechanisms of growth and atrophy of skeletal muscle. (1972) (36)
Physiological significance of protein degradation in animal and bacterial cells. (1974) (36)
Muscle Wasting in Fasting Requires Activation of NF-κB and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5* (2015) (35)
Properties of abnormal proteins degraded rapidly in reticulocytes. Intracellular aggregation of the globin molecules prior to hydrolysis. (1981) (35)
Guanosine-5'-diphosphate-3'-diphosphate (ppGpp) and the regulation of protein breakdown in Escherichia coli. (1980) (35)
γ-lnterferon and expression of MHC genes regulate peptide hydrolysis by proteasomes (1995) (34)
Functions of the proteasome in antigen presentation (1995) (34)
Effects od disuse and denervation on amino acid transport by skeletal muscle. (1969) (34)
Role and location of "protease I" from Escherichia coli (1976) (34)
Slowing muscle atrophy: putting the brakes on protein breakdown (2002) (33)
NONUNIFORM RATES OF TURNOVER OF MYOFIBRILLAR PROTEINS IN RAT DIAPHRAGM (1973) (33)
The role of increased proteolysis in the atrophy and arrest of proliferation in serum‐deprived fibroblasts (1984) (33)
An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR (2019) (33)
Affinity purification of mammalian 26S proteasomes using an ubiquitin-like domain. (2012) (32)
SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation (2019) (32)
An ATP-stabilized inhibitor of the proteasome is a component of the 1500-kDa ubiquitin conjugate-degrading complex. (1992) (32)
Vanadate inhibits the ATP-dependent degradation of proteins in reticulocytes without affecting ubiquitin conjugation. (1984) (31)
ATP-dependent proteases in prokaryotic and eukaryotic cells. (1990) (31)
Protease So from Escherichia coli preferentially degrades oxidatively damaged glutamine synthetase. (1988) (30)
In vivo inactivation of glycerol dehydrogenase in Klebsiella aerogenes: properties of active and inactivated proteins (1980) (30)
Protein Breakdown and the Heat-Shock Response (1988) (30)
Formation in vitro of complexes between an abnormal fusion protein and the heat shock proteins from Escherichia coli and yeast mitochondria (1991) (30)
ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation (2018) (29)
Preparation of hybrid (19S-20S-PA28) proteasome complexes and analysis of peptides generated during protein degradation. (2005) (28)
Degradation of abnormal proteins in Escherichia coli (protein breakdown-protein structure-mistranslation-amino acid analogs-puromycin). (1972) (28)
Functions of the proteasome in antigen presentation. (1995) (28)
The antibiotic cyclomarin blocks arginine-phosphate–induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis (2018) (28)
Cathepsins L and Z Are Critical in Degrading Polyglutamine-containing Proteins within Lysosomes* (2012) (27)
Purification and Characterization of Protease So, a Cytoplasmic Serine Protease in Escherichia coli (1983) (27)
Isolation and characterization of lon mutants in Salmonella typhimurium (1986) (26)
Regulation of different proteolytic pathways in skeletal muscle in fasting and diabetes mellitus. (1994) (26)
Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation (2016) (25)
On prions, proteasomes, and mad cows. (2007) (25)
Impairment of protein degradation and proteasome function in hereditary neuropathies (2018) (25)
Different ratios in 20 S proteasomes and regulatory subunit complexes in two isoforms of the 26 S proteasome purified from rabbit skeletal muscle (1993) (25)
Effects of temperature on protein turnover in isolated rat skeletal muscle. (1984) (25)
Comparison of the control and pathways for degradation of the acetylcholine receptor and average protein in cultured muscle cells (1981) (25)
Protein degradation by the proteasome and dissection of its in vivo importance with synthetic inhibitors (1997) (24)
Amino acid degradation and effect of leucine on pyruvate oxidation in rat atrial muscle. (1980) (24)
Reduction of protein degradation and atrophy in cultured fetal mouse hearts by leupeptin. (1979) (23)
Role of ATP hydrolysis in the degradation of proteins by protease la from Escherichia coli (1986) (22)
ATP-stimulated endoprotease is associated with the cell membrane of E. coli (1981) (22)
SELECTIVE DEGRADATION OF ABNORMAL PROTEINS IN ANIMAL AND BACTERIAL CELLS (1978) (21)
Studies of the protein encoded by the lon mutation, capR9, in Escherichia coli. A labile form of the ATP-dependent protease La that inhibits the wild type protease. (1983) (21)
Purification and characterization of protease Re, a cytoplasmic endoprotease in Escherichia coli (1988) (21)
STUDIES OF THE SELECTIVITY AND MECHANISMS OF INTRACELLULAR PROTEIN DEGRADATION (1976) (21)
Mitochondrial ATP-dependent protease from rat liver and yeast. (1994) (21)
Probing the proteasome pathway (2000) (21)
Effects of protease inhibitors on protein breakdown and enzyme induction in starving Escherichia coli. (1971) (21)
Keeping proteasomes under control—a role for phosphorylation in the nucleus (2011) (21)
Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies (2019) (20)
Measuring the Overall Rate of Protein Breakdown in Cells and the Contributions of the Ubiquitin-Proteasome and Autophagy-Lysosomal Pathways. (2018) (20)
hRpn 13 / ADRM 1 / GP 110 is a novel proteasome subunit that binds the deubiquitinating enzyme , UCH 37 (2006) (18)
ATPase and ubiquitin-binding proteins of the yeast proteasome (1997) (18)
Studies of the ATP dependence of protein degradation in cells and cell extracts. (2008) (17)
A possible explanation of myxedema and hypercholesterolemia in hypothyroidism: control of lysosomal hyaluronidase and cholesterol esterase by thyroid hormones. (1981) (17)
Structural properties of rat serum proteins which correlate with their degradative rates in vivo (1976) (15)
Atrogin1/MAFbx: what atrophy, hypertrophy, and cardiac failure have in common. (2011) (15)
The rate of protein degradation in isolated skeletal muscle does not correlate with reduction-oxidation status. (1985) (13)
The requirements of yeast Hsp70 of SSA family for the ubiquitin-dependent degradation of short-lived and abnormal proteins. (2016) (13)
Development of high throughput screening methods for inhibitors of ClpC1P1P2 from Mycobacteria tuberculosis. (2019) (13)
Purification and Characterization of Protease Ci, a Cytoplasmic Metalloendoprotease in Escherichia coli(*) (1995) (13)
Exploring the Regulation of Proteasome Function by Subunit Phosphorylation. (2018) (13)
Regulation of Protein and Amino Acid Degradation in Skeletal Muscle (1974) (13)
Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation (2021) (12)
Hsp104 is essential for the selective degradation in yeast of polyglutamine expanded ataxin-1 but not most misfolded proteins generally. (2010) (12)
Production of alanine and glutamine by atrial muscle from fed and fasted rats. (1980) (12)
Multiple myeloma cells are exceptionally sensitive to heat shock, which overwhelms their proteostasis network and induces apoptosis (2020) (11)
The ATP dependent pathway for protein breakdown in bacteria and mitochondria. (1985) (10)
N-End Rule (2002) (10)
Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates (2015) (10)
Structure-function relationship of tumour necrosis factor and its mechanism of action. (1987) (10)
Bortezomib’s Scientific Origins and Its Tortuous Path to the Clinic (2011) (9)
RELEASE OF GLUCONEOGENIC PRECURSORS FROM SKELETAL MUSCLE (1978) (9)
THE REGULATION OF PROTEIN TURNOVER BY ENDOCRINE AND NUTRITIONAL FACTORS (1980) (9)
Structure-function relationship of tumor necrosis factor and its mechanism of action (1987) (9)
The ATP-dependent breakdown of proteins in mammalian mitochondria. (1985) (8)
The apparent stimulation of proteolysis by adenosine triphosphate in tissue homogenates. (1973) (8)
Studies of the Pathway for Protein Degradation in Escherichia coli and Mammalian Cells (1979) (7)
Erratum: γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes (Nature (1993) 365 (264-267)) (1995) (7)
Introduction to the Proteasome and its Inhibitors (2004) (7)
SEPARATION OF ANTINVASIN I INTO TWO COMPONENTS (1947) (7)
Blocking Cancer Growth with Less POMP or Proteasomes. (2015) (6)
Not just research tools—proteasome inhibitors offer therapeutic promise (2002) (6)
Control of lysosomal enzyme activities in rat tissues by thyroid hormones (1977) (6)
nonlysosomal insulin-degrading proteinases in mammalian cells. (1981) (6)
A new model of cancer cachexia: contribution of the ubiquitin-proteasome pathway. (1999) (5)
) ClpP 1 and ClpP 2 Function Together in Protein Degradation and are Required for Viability \ ( in \ ) \ ( vitro \ ) and During Infection (2012) (5)
Inhibition of the proteasome β 2 site sensitizes triple-negative breast cancer cells to β 5 inhibitors through a mechanism involving Nrf1 suppression (2017) (5)
Blm 10 promotes proteasomal substrate turnover by an active gating mechanism (2011) (5)
Measurement of the Multiple Activities of 26S Proteasomes. (2018) (5)
Hormonal control of protein synthesis and degradation in rat skeletal muscle [proceedings]. (1977) (4)
S5a/Rpn10, a UIM-protein, as a universal substrate for ubiquitination. (2012) (4)
Regulation of protein degradation in skeletal muscle. (2003) (4)
ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria (2020) (4)
A relationship between the rates of acetyl group oxidation and the oxygen consumption of cellls. (1978) (4)
Lactacystin and clasto-Lactacystin b-Lactone Modify Multiple Proteasome b-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I (1997) (4)
Methods to Rapidly Prepare Mammalian 26S Proteasomes for Biochemical Analysis. (2018) (4)
What the Archaeal PAN–Proteasome Complex and Bacterial ATP‐Dependent Proteases Can Teach Us About the 26S Proteasome (2007) (3)
Ca2+, interleukin-1 and failure to maintain normal length stimulate protein degradation in isolated skeletal muscle. (1985) (3)
Structure and Functional Properties of the Active Form of the Proteolytic Complex , ClpP 1 P 2 , from Mycobacterium tuberculosis * (2016) (3)
26S proteasomes become stably activated upon heat shock when ubiquitination and protein degradation increase (2022) (3)
Protein Degradation and Turnover (2006) (3)
Regulation of protein degradation in skeletal muscle (1980) (3)
Formation of nondegradable forked ubiquitin conjugates by ring-finger ligases and its prevention by S5a. (2012) (3)
The Regulation of Protein Breakdown by Prostaglandins (1983) (3)
Trials for the Treatment of Secondary Wasting and Cachexia Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States 1 , 2 (1999) (3)
THE UIM PROTEIN, S5A, IS UBIQUITINATED BY ALL TYPES OF UBIQUITIN LIGASES BY A MECHANISM DIFFERENT FROM TYPICAL SUBSTRATE RECOGNITION (2009) (2)
ERAP1 and MHC Class I Antigen Presentation (2004) (2)
Alfred L. Goldberg: Probing the Proteasome. (2016) (2)
Raising cGMP restores proteasome function and myelination in mice with a proteotoxic neuropathy. (2021) (2)
Isolation and Characterization of Ion Mutants in Salmonella typhimurium (2)
The mechanism and regulation of the ATP-dependent protease La from Escherichia coli. (1987) (2)
Duo-activation of PKA and PKG by PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against proteinopathy (2019) (2)
Lon-A Peptidase, Endopeptidase La (2013) (1)
Improved methods for purification and assay of glycerol kinase from Escherichia coli. (1988) (1)
How peptides are generated for MHC class i antigen presentation (1997) (1)
ATP Serves Two Distinct Roles in Protein Degradation in Reticulocytes, and One Independent of Ubiquitin One Requiring (2002) (1)
Studies of the Degradation of Proteins in Animal and Bacterial Cells (1977) (1)
Degradation of Abnormal Proteins in Escl (2016) (1)
O.20 BMP signalling controls muscle mass (2013) (0)
cerevisiae Saccharomyces Confer Thermotolerance in Shock Proteins and Trehalose , Which Together Proteasome Inhibitors Cause Induction of Heat (1997) (0)
ClpAP and ClpXP Proteinases (2002) (0)
Proteasomes playan essential roleinthymocyte apoptosis (1996) (0)
Protein degradation and defense against neurodegenerative disease 2 (2014) (0)
New soluble ATP-dependent protease, Ti, in Escherichia coli that is distinct from protease La (1987) (0)
TICB 1285 No . of Pages 3 Series : From the Archive (2016) (0)
Pharmacological Inhibitors of the Proteosome in Atrophying Muscles (1999) (0)
PNAS Plus Significance Statements (2015) (0)
LA (Lon) Proteinase (2002) (0)
Abstracts of Papers at The Sixty-Third Annual Meeting of The Society of General Physiologists: MUSCLE in Health and Disease (2009) (0)
Abstract 100: Dual Activation of PKA and PKG by PDE1 Inhibition Facilitates Proteasomal Degradation of Misfolded Proteins and Protects Against Proteinopathy-Based HFpEF (2019) (0)
Initial Binding of Ubiquitylated Proteins to the Proteasome (2017) (0)
Major Histocompatibility Complex Class Ipresented Ipresented Ipresented Antigenic Peptides Are Degraded in Cytosolic Extracts Primarily by Thimet (2001) (0)
Identification of Usp8 as a toxicity modifying Deubiquitinase for alpha-synuclein (2017) (0)
A RoleofAminoacyl-tRNA intheRegulation ofProtein Breakdown inEscherichia coli (1971) (0)
Cellular 26S Proteasome Activity And Content Is Increased In Response To Oxidative Stress (2012) (0)
Structure of the 26S proteasome-Ubp6 complex (2015) (0)
Liver mitochondria contain an ATF pathway for the degradation of pro (organelle turnover/abnormal proteins/energy requirement/lysoson (2016) (0)
Dieter Wolf (1941-2023): a life dedicated to understanding protein quality control and the ubiquitin-proteasome system. (2023) (0)
Introduction to the Proteasome and its Inhibitors Biochemistry and Cell Biology (2019) (0)
Neurodegenerative Diseases: Protein misfolding and cellular defense mechanisms in neurodegenerative diseases (2005) (0)
NEW INSIGHTS INTO THE PROTEASOME FUNCTION AND DEGRADATION OF MISFOLDED PROTEINS (2018) (0)
Function of the proteasome in protein turnover and antigen presentation (1996) (0)
Thermoplasma acidophilum 20S proteasome with a closed gate (2008) (0)
Protein Turnover | Intracellular Protein Degradation (2020) (0)
Patents and literature (1990) (0)
Printed in Great Britain The Apparent Stimulation of Proteolysis by Adenosine Triphosphate in Tissue (2005) (0)
STUDIES OF THE MECHANISM AND SELECTIVITY OF INTRACELLULAR PROTEIN BREAKDOWN (1979) (0)
Regulation of Protein Balance in Muscle during Fever: Role of Prostaglandins and Interleukin-1 (1985) (0)
Mammalian Ddi2 is a shuttling factor containing a retroviral protease domain that influences binding of ubiquitylated proteins and proteasomal degradation (2022) (0)
Membrane-associated proteolytic activity in Escherichia coli that is stimulated by ATP (1986) (0)
Allosteric Regulation of Nucleotide Binding to the Proteasomal ATPases (2012) (0)
NMR structure of lassomycin (2014) (0)
Combinations of necrosis-tumor-factors and entzuendungshemmenden agents for the treatment of malignant and non-malignant diseases. (1987) (0)
Protein degradation and defense against neurodegenerative disease - part 2 of 2 (2014) (0)
Host for producing recombinant product in high yield (1993) (0)
Cancer Vulnerabilities Unveiled by Genomic Loss Citation (2012) (0)
DNA stimulates ATP-dependent pr( ATPase activity of protease La fron (lon gene/capR/protein degradation/DNA-binding protein) (2016) (0)

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