Alfred Singer
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- PhD Computer Science Stanford University
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(Suggest an Edit or Addition)Alfred Singer's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2 (2005) (657)
- Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. (2004) (542)
- Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice (2008) (476)
- Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction. (1992) (301)
- Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells. (2000) (298)
- Crosstalk in the mouse thymus. (1994) (293)
- Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28 (1994) (287)
- Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells (2010) (243)
- Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection. (1995) (238)
- T cell development in mice that lack the zeta chain of the T cell antigen receptor complex. (1993) (231)
- Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells. (2012) (222)
- Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection (1987) (200)
- Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. (2013) (198)
- Disorganization and restoration of thymic medullary epithelial cells in T cell receptor‐negative scid mice: Evidence that receptor‐bearing lymphocytes influence maturation of the thymic microenvironment (1991) (198)
- New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision. (2002) (178)
- 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR (2007) (178)
- Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules (1993) (176)
- Inhibition of T‐cell receptor beta‐chain gene rearrangement by overexpression of the non‐receptor protein tyrosine kinase p56lck. (1992) (173)
- Self recognition in allogeneic radiation bone marrow chimeras. A radiation- resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells (1981) (170)
- Deletion of CD4 and CD8 Coreceptors Permits Generation of αβT Cells that Recognize Antigens Independently of the MHC (2007) (152)
- In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8+ T Cells (2003) (152)
- Clonal deletion and the fate of autoreactive thymocytes that survive negative selection (2012) (149)
- Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities (1990) (147)
- Cellular and genetic control of antibody responses. V. Helper T-cell recognition of H-2 determinants on accessory cells but not B cells (1979) (146)
- Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus. (1996) (140)
- Cell surface appearance of unexpected host MHC determinants on thymocytes from radiation bone marrow chimeras. (1981) (139)
- IL-7 Receptor Signals Inhibit Expression of Transcription Factors TCF-1, LEF-1, and RORγt (2004) (135)
- Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain (1989) (134)
- T Cell Receptor (TCR)-induced Death of Immature CD4+CD8+ Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus (1997) (133)
- Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4. (1990) (127)
- Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals. (1997) (126)
- Negative selection of precursor thymocytes before their differentiation into CD4+CD8+ cells. (1992) (122)
- Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC. (2007) (119)
- The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype‐independent CD3 complexes. (1995) (118)
- Persistence of glucose residues on core oligosaccharides prevents association of TCR alpha and TCR beta proteins with calnexin and results specifically in accelerated degradation of nascent TCR alpha proteins within the endoplasmic reticulum. (1994) (117)
- Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction (1999) (114)
- Mechanisms of T cell-B cell interaction. (1983) (113)
- IL-7 signaling must be intermittent, not continuous, during CD8 T cell homeostasis to promote cell survival instead of cell death (2012) (111)
- T cell-accessory cell interactions that initiate allospecific cytotoxic T lymphocyte responses: existence of both Ia-restricted and Ia-unrestricted cellular interaction pathways. (1984) (111)
- Analysis of T-cell subsets in rejection of Kb mutant skin allografts differing at class I MHC (1986) (107)
- Let-7 miRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function (2015) (105)
- Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains (1994) (104)
- Role of CD8β Domains in CD8 Coreceptor Function (2000) (104)
- Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4(+) T cells: evidence from a lymphopenic T cell model. (2002) (104)
- Phenotype, ontogeny, and repertoire of CD4-CD8- T cell receptor alpha beta + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage. (1991) (104)
- CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision. (2004) (104)
- Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self (1985) (102)
- αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities. (2012) (102)
- Lck Availability during Thymic Selection Determines the Recognition Specificity of the T Cell Repertoire (2013) (100)
- Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor beta (1994) (96)
- Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection (2006) (96)
- Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperones. (1997) (95)
- T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences (2017) (94)
- Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens (1986) (92)
- A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. (1997) (91)
- Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC (1994) (90)
- Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes (1988) (89)
- TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck. (1996) (87)
- Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus (2012) (86)
- Role of CD4 in thymocyte selection and maturation (1989) (86)
- Post-transcriptional regulation of early T cell development by T cell receptor signals. (1992) (85)
- Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes. (1994) (84)
- Induction of autoimmune disease in CTLA-4−/− mice depends on a specific CD28 motif that is required for in vivo costimulation (2007) (84)
- Cellular and genetic control of antibody responses in vitro. III. Immune response gene regulation of accessory cell function (1978) (83)
- A TCR mechanotransduction signaling loop induces negative selection in the thymus (2018) (83)
- Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells. (1994) (83)
- Role of the major histocompatibility complex in T cell activation of B cell subpopulations. lyb-5(+) and lyb-5(-) B cell subpopulations differ in their requirement for major histocompatibility complex-restricted T cell recognition (1981) (82)
- T cell receptor‐negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway (1990) (80)
- Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus. (2000) (79)
- In vivo calcium elevations in thymocytes with T cell receptors that are specific for self ligands. (1992) (78)
- Role of accessory cell processing and presentation of shed H-2 alloantigens in allospecific cytotoxic T lymphocyte responses. (1984) (78)
- Cellular basis of skin allograft rejection across a class I major histocompatibility barrier in mice depleted of CD8+ T cells in vivo (1991) (77)
- MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection. (2012) (75)
- TCRα-CD3δϵ association is the initial step in αβ dimer formation in murine T cells and is limiting in immature CD4+CD8+ thymocytes (1995) (74)
- Role of the H-2 complex in the induction of T cell tolerance to self minor histocompatibility antigens (1983) (72)
- Role of accessory cells in B cell activation. I. Macrophage presentation of TNP-Ficoll: evidence for macrophage-B cell interaction. (1980) (71)
- Chromatin remodeling complex NURF regulates thymocyte maturation. (2011) (71)
- Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes (1994) (71)
- Growth Factor Independence-1B Expression Leads to Defects in T Cell Activation, IL-7 Receptor α Expression, and T Cell Lineage Commitment1 (2003) (70)
- Self recognition in allogeneic thymic chimeras. Self recognition by T helper cells from thymus-engrafted nude mice is restricted to the thymic H-2 haplotype (1982) (69)
- Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells (1983) (69)
- Recognition Requirements for the Activation, Differentiation and Function of T‐Helper Cells Specific for Class I MHC Alloantigens (1987) (69)
- Role of lymphokine-secreting CD8+ T cells in cytotoxic T lymphocyte responses against vaccinia virus. (1989) (68)
- The H-2 phenotype of the thymus dictates the self-specificity expressed by thymic but not splenic cytotoxic T lymphocyte precursors in thymus-engrafted nude mice. (1981) (68)
- Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity. (2005) (68)
- Cellular and genetic control of antibody responses in vitro. IV. Expression of Ia antigens on accessory cells required for responses to soluble antigens including a response under Ir gene control. (1978) (67)
- Cellular and genetic control of antibody responses in vitro 1.cellular requirements for the generation of genetically controlled primary IgM responses to soluble antigens (1977) (65)
- In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help. (1990) (65)
- Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4 (1990) (64)
- Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes. (2001) (64)
- Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells. (1994) (63)
- Role of the major histocompatibility complex in T cell activation of B cell subpopulations. Major histocompatibility complex-restricted and -unrestricted B cell responses are mediated by distinct B cell subpopulations (1981) (61)
- Distinct B Cell Subpopulations Differ in Their Genetic Requirements for Activation by T Helper Cells (1982) (61)
- TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells (2015) (59)
- Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia- restricted T cells but not H-2K/D-restricted T cells (1982) (57)
- T-cell recognition of a chimaeric class II/class I MHC molecule and the role of L3T4 (1985) (56)
- Expression of an unusual T cell receptor (TCR)-V beta repertoire by Ly-6C+ subpopulations of CD4+ and/or CD8+ thymocytes. Evidence for a developmental relationship between Ly-6C+ thymocytes and CD4-CD8-TCR-alpha beta+ thymocytes. (1991) (55)
- The transcription factor ThPOK suppresses Runx3 and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling (2014) (55)
- Lineage Commitment in the Thymus: Only the Most Differentiated (TCRhibcl-2hi) Subset of CD4+CD8+Thymocytes Has Selectively Terminated CD4 or CD8 Synthesis (1996) (54)
- Role of accessory cells in B cell activation. II. The interaction of B cells with accessory cells results in the exclusive activation of an Lyb5+ B cell subpopulation. (1980) (53)
- Specificity, phenotype, and precursor frequency of primary cytolytic T lymphocytes specific for class II major histocompatibility antigens. (1985) (53)
- Role of the major histocompatibility complex in T cell activation of B cell subpopulations. A single monoclonal T helper cell population activates different B cell subpopulations by distinct pathways (1982) (53)
- Evidence that the effector mechanism of skin allograft rejection is antigen-specific. (1988) (52)
- CD5‐mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain (2002) (51)
- Relationship among function, phenotype, and specificity in primary allospecific T cell populations: identification of phenotypically identical but functionally distinct primary T cell subsets that differ in their recognition of MHC class I and class II allodeterminants. (1987) (50)
- Differential effects of zeta and eta transgenes on early alpha/beta T cell development (1994) (49)
- Maturation Versus Death of Developing Double-Positive Thymocytes Reflects Competing Effects on Bcl-2 Expression and Can Be Regulated by the Intensity of CD28 Costimulation1 (2001) (48)
- Unraveling a Revealing Paradox (2003) (47)
- Specific prolongation of MHC class II disparate skin allografts by in vivo administration of anti-IFN-gamma monoclonal antibody. (1990) (46)
- Evidence for involvement of dual-function T cells in rejection of MHC class I disparate skin grafts. Assessment of MHC class I alloantigens as in vivo helper determinants (1988) (45)
- Role of accessory cells in B cell activation. III. Cellular analysis of primary immune response deficits in CBA/N mice: presence of an accessory cell-B cell interaction defect (1980) (44)
- Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire (2019) (44)
- Role of accessory cells in B cell activation. IV. Ia+ accessory cells are required for the in vitro generation of thymic independent type 2 antibody responses to polysaccharide antigens. (1981) (42)
- The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells (2012) (41)
- Major histocompatibility complex-restricted self recognition. A monoclonal anti-I-Ak reagent blocks helper T cell recognition of self major histocompatibility complex determinants (1980) (39)
- Coreceptor Signal Strength Regulates Positive Selection but Does Not Determine CD4/CD8 Lineage Choice in a Physiologic In Vivo Model1 (2006) (38)
- Differences in the MHC-restricted self-recognition repertoire of intra-thymic and extra-thymic cytotoxic T lymphocyte precursors. (1983) (38)
- Characterization of antigen-specific, Ia-restricted, L3T4+ cytolytic T lymphocytes and assessment of thymic influence on their self specificity (1985) (38)
- Cellular and genetic control of antibody responses. VI. Expression of Ir gene function by H-2a accessory cells, but not H-2a T or B cells in responses to TNP-(T,G)-A--L. (1979) (36)
- Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell‐surface expression (1988) (36)
- Cell surface comodulation of CD4 and T cell receptor by anti-CD4 monoclonal antibody. (1989) (35)
- T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1 (2014) (34)
- Ia+ murine epidermal Langerhans cells are deficient in surface expression of the class I major histocompatibility complex. (1986) (34)
- Positive Selection as a Developmental Progression Initiated by αβTCR Signals that Fix TCR Specificity prior to Lineage Commitment (1999) (32)
- CORRELATION OF INTRATHYMIC TOLERANCE WITH INTRATHYMIC CHIMERISM IN NEONATALLY TOLERIZED MICE (1985) (32)
- Graft-vs-host reaction limited to a class II MHC difference results in a selective deficiency in L3T4+ but not in Lyt-2+ T helper cell function. (1987) (32)
- ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4+8+ Thymocytes with Limiting p56lck (1999) (32)
- Role of Self Antigens in the Selection of the Developing T Cell Repertoire (1986) (31)
- Characterization of primary T cell subsets mediating rejection of pancreatic islet grafts. (1989) (31)
- Early TCRα expression generates TCRαγ complexes that signal the DN-to-DP transition and impair development (2002) (30)
- Tolerance of thymocytes to allogeneic i region determinants encountered prethymically. Evidence for expression of anti-Ia receptors by T cell precursors before their entry into the thymus (1982) (30)
- Signals involved in CD4/CD8 lineage commitment: current concepts and potential mechanisms. (1999) (29)
- The specificity of the syngeneic mixed leukocyte response, a primary anti-I region T cell proliferative response, is determined intrathymically. (1982) (29)
- Tolerance of thymic cytotoxic T lymphocytes to allogeneic H-2 determinants encountered prethymically: evidence for expression of anti-H-2 receptors prior to entry into the thymus. (1982) (29)
- Cytotoxic T lymphocyte responses by chimeric thymocytes. Self- recognition is determined early in T cell development (1981) (28)
- Rejection of skin allografts by CD4+ T cells is antigen-specific and requires expression of target alloantigen on Ia- epidermal cells. (1989) (28)
- The suppressive effect of immunization on the proliferative responses of rat T cells in vitro. II. Abrogation of antigen-induced suppression by selective cytotoxic agents. (1976) (27)
- PHENOTYPIC CHARACTERIZATION OF EARLY EVENTS OF THYMUS REPOPULATION IN RADIATION BONE MARROW CHIMERAS (1983) (27)
- Recognition of MHC class I allodeterminants regulates the generation of MHC class II-specific CTL. (1986) (26)
- Functional helper activity of monoclonal T cell populations: antigen-specific and H-2 restricted cloned T cells provide help for in vitro antibody responses to trinitrophenyl-poly(LTyr,Glu)-poly(DLAla)--poly(LLys). (1981) (26)
- Coreceptor gene imprinting governs thymocyte lineage fate (2011) (26)
- Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene. (1993) (26)
- Inhibition of allorecognition by an H-2Kb-derived peptide is evidence for a T-cell binding region on a major histocompatibility complex molecule. (1989) (26)
- Role of the major histocompatibility complex in T cell activation of B cell subpopulations. Ir gene regulation of the T cell-dependent activation of distinct B cell subpopulations. (1983) (25)
- Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes. (1991) (25)
- Inverse correlation between steady‐state RNA and cell surface T cell receptor levels (1990) (25)
- Identification of lineage-specifying cytokines that signal all CD8-cytotoxic lineage fate decisions in the thymus (2017) (25)
- CD8 Coreceptor Extinction in Signaled CD4+CD8+ Thymocytes: Coordinate Roles for Both Transcriptional and Posttranscriptional Regulatory Mechanisms in Developing Thymocytes (2000) (24)
- Early TCRalpha expression generates TCRalphagamma complexes that signal the DN-to-DP transition and impair development. (2002) (24)
- Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes. (1993) (24)
- Analysis of two distinct B cell activation pathways mediated by a monoclonal T helper cell. II. T helper cell secretion of interleukin 4 selectively inhibits antigen-specific B cell activation by cognate, but not noncognate, interactions with T cells. (1988) (23)
- T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically (1983) (22)
- Commitment of Immature CD4+8+ Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains (1997) (22)
- TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes. (1995) (21)
- Cellular and genetic control of antibody responses in vitro. II. Ir gene control of primary IgM responses to trinitrophenyl conjugates of poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys and poly-L-(His,Glu)-poly-D,L- Ala--poly-L-Lys (1977) (20)
- Differentiation of Ia-reactive CD8+ murine T cells does not require Ia engagement. Implications for the role of CD4 and CD8 accessory molecules in T cell differentiation (1988) (20)
- Self recognition of accessory cell Ia determinants is required for the in vitro generation of hapten-specific cytotoxic T lymphocyte responses. (1983) (19)
- Stoichiometry of the T cell Antigen Receptor ( TCR ) Complex : Each TCR / CD 3 Complex Contains One TCR ol , One TCR [ 3 , and Two CD 3 e Chains (2003) (19)
- Experimentation and thymic selection. (1988) (19)
- Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors (2016) (18)
- Presence of CD4 and CD8 determinants on CD4−CD8− murine thymocytes: passive acquisition of CD8 accessory molecules (1991) (17)
- Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation (2018) (17)
- Major histocompatibility complex-restricted self-recognition in responses to trinitrophenyl-ficoll. Adaptive differentiation and self- recognition by B cells (1982) (17)
- Developmental regulation of αβ T cell antigen receptor assembly in immature CD4+CD8+ thymocytes (1995) (17)
- Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice. (2009) (17)
- Functional heterogeneity of the Lyb-5- B cell subpopulation: mutant xid B cells and normal Lyb-5- B cells differ in their responsiveness to phenol-extracted lipopolysaccharide. (1983) (17)
- Dichotomy in the tissue origin of schistosome acquired class I and class II major histocompatibility complex antigens (1984) (16)
- Regulation of MHC Class I Expression by Foxp3 and Its Effect on Regulatory T Cell Function (2014) (16)
- Cellular and genetic control of antibody responses. VIII. MHC restricted recognition of accessory cells, not B cells, by parent-specific subpopulations of normal F1 T helper cells. (1980) (15)
- Induction of anti-CD8 resistant cytotoxic T lymphocytes by anti-CD8 antibodies. Functional evidence for T cell signaling induced by multi-valent cross-linking of CD8 on precursor cells. (1988) (15)
- IL-1 as a co-factor for lymphokine-secreting CD8+ murine T cells. (1988) (15)
- Differential helper and effector responses of Lyt-2+ T cells to H-2Kb mutant (Kbm) determinants and the appearance of thymic influence on anti-Kbm CTL responsiveness. (1986) (14)
- Characterization of anti-CD8-resistant cytolytic T lymphocytes induced by multivalent cross-linking of CD8 on precursor cells. (1989) (14)
- Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks (2000) (13)
- Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation (2004) (13)
- Specificity of thymic selection and the role of self antigens. (1987) (13)
- Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes. (1993) (13)
- Homologies between cell interaction molecular controlled by major histocompatibility complex- and Igh-V-linked genes that T cells use for communication. Tandem "adaptive" differentiation of producer and acceptor cells (1982) (13)
- E-protein–regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex (2019) (13)
- CD28 Ligation Costimulates Cell Death but Not Maturation of Double-Positive Thymocytes due to Defective ERK MAPK Signaling1 (2006) (12)
- Positive selection of CD4+ T cells by TCR‐specific antibodies requires low valency TCR cross‐linking: implications for repertoire selection in the thymus (1998) (11)
- Negative Selection of CD 4 + CD 8 + Thymocytes by T Cell Receptor-induced Apoptosis Requires a Costimulatory Signal that Can Be Provided by CD 28 By (2003) (11)
- Basis of Treg development in the thymus (2014) (11)
- Lineage Commitment in the Thymus : Only the Most Differentiated ( TCR hi bcl-2 hi ) Subset of CD 4 1 CD 8 1 Thymocytes Has Selectively Terminated CD 4 or CD 8 Synthesis (1996) (11)
- Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus (2022) (11)
- T cells from fully H-2 allogeneic (A replaced by B) radiation bone marrow chimeras are functionally competent and host restricted but are alloreactive against hybrid Ia determinants expressed on (A x B)F1 cells (1982) (10)
- Cell surface expression of the amino-terminal domain of A kappa alpha. Recognition of an isolated MHC antigenic structure by allospecific T cells but not alloantibodies. (1988) (10)
- Major histocompatibility complex-restricted self-recognition in responses to trinitrophenyl-Ficoll. A novel cell interaction pathway requiring self-recognition of accessory cell H-2 determinants by both T cells and B cells (1983) (10)
- Intrathymic differentiation and tolerance induction of lymphokine-secreting Lyt-2+ T helper cells. (1988) (9)
- Homologies between cell interaction molecules controlled by major histocompatibility complex‐ and Igh‐V‐linked genes that T cells use for communication; both molecules undergo “adaptive” differentiation in the thymus (1983) (9)
- Programming for cytotoxic effector function occurs concomitantly with CD4 extinction during CD8(+) T cell differentiation in the thymus. (2000) (9)
- Generation of primary murine CTL specific for allogeneic and xenogeneic MHC determinants upon stimulation with murine L cells transfected with class I genes. (1985) (9)
- Quantitative differences in cell surface expression of class I MHC antigens on murine epidermal Langerhans cells. (1994) (9)
- Isolation of immature and mature T cell receptor complexes by lectin affinity chromatography. (1994) (9)
- Targeting CD4 Coreceptor Expression to Postselection Thymocytes Reveals That CD4/CD8 Lineage Choice Is neither Error-Prone nor Stochastic1 (2008) (9)
- AIDS therapy by blocking CD4+ cells (1986) (9)
- Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment. (1999) (8)
- MHC-restricted recognition by antigen-specific B cells: fact or artefact? (1984) (8)
- CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation (2018) (8)
- Importance of CD8+ T helper cell function in AIDS. (1988) (8)
- CHARACTERIZATION OF THE ACCESSORY CELLS REQUIRED IN T LYMPHOCYTE DEPENDENT ANTIGEN-SPECIFIC IMMUNE RESPONSES (1980) (7)
- Lyb-5+ B cells can be activated by major histocompatibility complex-restricted as well as unrestricted activation pathways. (1985) (7)
- Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cells. (1994) (7)
- Cellular Interactions Resulting in Skin‐Allograft Rejection (1988) (6)
- Role of the major histocompatibility complex in T cell activation of B cell subpopulations: antigen-specific and H-2-restricted monoclonal TH cells activate Lyb-5+ B cells through an antigen-nonspecific and H-2-unrestricted effector pathway. (1982) (6)
- Cellular and genetic control of antibody responses. VII. Absence of detectable suppression maintaining the H-2 restricted recognition of F1 leads to parent helper T cells. (1980) (6)
- Coreceptor gene “imprinting:” A genetic solution to a developmental dilemma in T cells (2012) (5)
- Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes. (1995) (5)
- OBTAINING ADHERENT CELLS FROM SPLEEN (1981) (4)
- Major Histocompatibility Complex Restricted Self‐Recognition by B Cells and T Cells in Responses to TNP‐Ficoll (1983) (4)
- Anti-(T,G)-A–L Idiotypes: Initial Studies of Genetic Control and Cellular Expression (1979) (4)
- Early Progression of Thymocytes along the CD 4 / CD 8 Developmental Pathway Is Regulated by a Subset of Thymic Epithelial Cells Expressing Transforming Growth (2003) (4)
- 32 – Mechanism of B Cell Activation by Monoclonal T Helper Cell Populations (1982) (3)
- Molecular and cellular basis of T cell lineage commitment: An overview. (2010) (3)
- Regulation of T15 idiotype dominance. III. Phosphocholine-specific B-cell activation in vivo requires major histocompatibility complex-restricted T-cell help. (1986) (3)
- Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155 (2020) (3)
- MHC restriction in T cell/B cell interaction: role of B-cell subpopulations and B-cell activation state. (1984) (3)
- Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect. (1992) (2)
- MHC restriction is imposed on a diverse TCR repertoire by CD4 and CD8 coreceptors during thymic selection (2012) (2)
- T cell development (1995) (2)
- Antigen specific effector mechanisms in skin allograft rejection. (1989) (2)
- The immune defect of cba/n mice arises from the inability of cba/n b cells to respond to activation signals from antigen presenting macrophages. Abstr. (1980) (2)
- Limiting dilution analysis of primary cytotoxic T-cell precursors. (1997) (2)
- Expression of I-Subregion Encoded Antigens on Accessory Cell Populations (1978) (2)
- Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus (2020) (2)
- Ir Gene Regulation of Accessory Cell Function (1978) (1)
- CD4+ T-cell responses to self-peptide--MHC. (2003) (1)
- T-lymphocyte associative recognition. (1989) (1)
- Commitment Expression , and T Cell Lineage α Receptor Leads to Defects in T Cell Activation , IL-7 Growth Factor Independence-1 B Expression (2003) (1)
- Chapter 4 – Role of Prethymic and Intrathymic Elements in the Induction of T Cell Tolerance to Allogeneic Determinants: The Thymus Is Not Sufficient to Prevent Autoreactivity (1983) (1)
- CD 28 Ligation Costimulates Cell Death but Not Maturation of Double-Positive Thymocytes due to Defective ERK MAPK Signaling 1 (2006) (1)
- Expression of Ir Genes and Ia Antigens by Adherent Accessory Cells Required for Antigen-Specific Antibody-Forming Cell Responses (1980) (1)
- Immune mechanisms of tissue destruction in vivo. (1988) (1)
- MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTED HELPER T CELL RECOGNITION OF ACCESSORY CELLS BUT NOT B CELLS (1980) (1)
- Cellular and Genetic Control of Antibody Responses (1979) (1)
- The role of CD4/L3T4 in T-lymphocyte function. (1987) (1)
- A peptide derived from the alpha-helical region of class I MHC blocks CTL engagement of the class I MHC molecule. (1989) (1)
- T cell subsets mediating rejection of established fetal pancreas grafts and failure to observe graft adaptation. (1990) (1)
- MHC-independent αβT cells: Lessons learned about thymic selection and MHC-restriction (2022) (1)
- Unraveling a Revealing Paradox: Why Major Histocompatibility Complex I–signaled Thymocytes Appear as CD4 (cid:2) 8 lo Transitional Cells During Positive Selection of CD8 (cid:2) T Cells (2003) (0)
- Developmental Arrest of T Cell Receptor (TcR) Negative SCID Thymocytes and Release in the Presence of TcR+ Cells (1989) (0)
- Table of Contents (1994) (0)
- recognition and its disorders (2009) (0)
- Table of Contents (1994) (0)
- Markedly asymmetric requirements for commitment to the CD4+ vs. CD8+ T cell lineage (1995) (0)
- Costimulation Can Be Regulated by the Intensity of CD 28 Competing Effects on Bcl-2 Expression and Double-Positive Thymocytes Reflects Maturation Versus Death of Developing (2001) (0)
- Foxp3 is pro-apoptotic and responsible for the cytokine dependence of regulatory T cells (2012) (0)
- I-a bearing adherent cells are required for the primary antibody response to ti-2 antigens. Abstr. (1980) (0)
- Disruption of intrathymic CD4-Ia interactions on immature CD4+CD8+ thymocytes results in diminished TCR expression on mature CD8+ T cell progeny. (1995) (0)
- A TCR mechanotransduction signaling loop induces negative selection in the thymus (2018) (0)
- Defined (cid:2)(cid:3) T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation (2004) (0)
- Major histocompatibility complex restriction in t cell b cell interaction role of b cell subpopulations and b cell activation state (1984) (0)
- Detection of a new b cell subpopulation (lyb-5n) which is lyb-5- but absent in xid mice. Abstr. (1982) (0)
- Repertoire differences between functionally distinct Lyt2+ T cell subpopulations (1985) (0)
- How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion (2023) (0)
- T cell development (PP-058) (2010) (0)
- ROLE OF CD4 IN THYMOCYTE SELECTION (1989) (0)
- BRD4 Deficiency Selectively Affects a Unique Developmental Subpopulation in Thymocytes (2018) (0)
- TAF7 is essential for early embryonic mouse development (2011) (0)
- The major histocompatibility complex (MHC)Lencoded determinants that T cells recognize for responses to conventional (non-MHC) antigens are referred to as "self"- (2003) (0)
- Immune response gene regulation of accessorry cell function of non-t, non-b spleen adherent cells. Abstr. (1978) (0)
- Author response: T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences (2017) (0)
- Error-Prone nor Stochastic CD 4 / CD 8 Lineage Choice Is neither Postselection Thymocytes Reveals That Targeting CD 4 Coreceptor Expression to Alfred (2008) (0)
- Science Signaling Podcast: 26 August 2014 (2014) (0)
- CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation (2018) (0)
- Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire (2019) (0)
- FUNCTIONAL STUDIES OF IMMUNE RESPONSE UTILIZING MURINE T CELL CLONES (1982) (0)
- Genetic restriction of helper t cell recognition of lyb5+ and lyb5- b cells. Abstr. (1981) (0)
- [Crucial role of CD4 and CD8 coreceptors in antigen recognition of αβT lymphocytes]. (2014) (0)
- T CELL RECOGNITION OF SYNGENEIC AND ALLOGENEIC H-2 DETERMINANTS (1979) (0)
- 118 Coreceptor Tuning: IL-7 Signals Transcriptionally Tailor CD8 Coreceptor Expression in CD8 T Cells to the Self-specificity of their TCR (2007) (0)
- Analysis of t cell functions in anti ia treated mice. Abstr. (1982) (0)
- Cloned t cells provide antigen-specific and h-2 restricted help in an igm antibody response. Abstr. (1981) (0)
- Strong TCR signaling prolongs lineage uncertainty during MHC-I specific positive selection (HEM8P.241) (2015) (0)
- In Vitro Generation of CTL Effectors from the Thymus and Spleen of Recently Reconstituted Radiation Chimeras Requires the Presence of Il-2 (2003) (0)
- Differential Effects of ~" and ~/Transgenes on Early c~//~ T Cell Development By Paul E. Love,* Elizabeth W. Shores,~ Eric J. Lee,* (1994) (0)
- Thymic selection (WS-032) Chairpersons: Taishin Akiyama, Ed Palmer (2010) (0)
- Intrathymic mhc-restricted ctl recognition patterns. Abstr. (1981) (0)
- Major histocompatibility complex-restricted recognition by B lymphocytes and accessory cells (1983) (0)
- MHC-independent T-cell receptor B12A (2019) (0)
- Pillars Article: Coreceptor Reversal in the Thymus: Signaled CD4+8+ Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8+ T Cells. Immunity. 2000. 13: 59-71. (2016) (0)
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