Alfred Wittinghofer

Alfred Wittinghofer's AcademicInfluence.com Rankings

Alfred Wittinghofer

Biology

#2987

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#4640

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Biochemistry

#398

World Rank

#475

Historical Rank

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Biology

Alfred Wittinghofer's Degrees

PhD Chemistry University of Marburg

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According to Wikipedia, Alfred "Fred" Wittinghofer is a German biochemist. Education and career At RWTH Aachen University he studied chemistry from 1963 with Diplom in 1968 and with doctorate in 1971. His doctoral work was done at RWTH Aachen University's Deutsches Wollforschungsinstitut . He worked from 1971 to 1973 as a postdoc at the University of North Carolina. At Heidelberg's Max Planck Institute for Medical Research he was 1974 from 1979 a scientific assistant and 1980 from 1993 a research group leader. In 1992 he completed his habilitation in biochemistry at the University of Heidelberg. At Dortmund's Max Planck Institute for Molecular Physiology, he was from 1993 to 2009 director of the structural biology department and from 2009 to 2016 "Emeritus Scientific Member" of the institute. From 1994 to 2009 he was Honorarprofessor for biochemistry at the Ruhr University Bochum.

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Alfred Wittinghofer's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP (1998) (1984)
The P-loop--a common motif in ATP- and GTP-binding proteins. (1990) (1944)
The Guanine Nucleotide-Binding Switch in Three Dimensions (2001) (1719)
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. (1997) (1420)
GEFs and GAPs: Critical Elements in the Control of Small G Proteins (2007) (1394)
Refined crystal structure of the triphosphate conformation of H‐ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. (1990) (1005)
An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms (2005) (788)
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation (1989) (787)
The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue (1995) (611)
The ras protein family: evolutionary tree and role of conserved amino acids. (1991) (551)
Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling (2013) (510)
RanGAP1 induces GTPase activity of nuclear Ras-related Ran. (1994) (507)
GTPase-activating proteins: helping hands to complement an active site. (1998) (438)
Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis (1990) (435)
Structural insight into filament formation by mammalian septins. (2007) (417)
Structure-function relationships of the G domain, a canonical switch motif. (2011) (399)
Mechanism of Regulation of the Epac Family of cAMP-dependent RapGEFs* (2000) (394)
Kinetics of interaction of nucleotides with nucleotide-free H-ras p21. (1990) (375)
Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules (1990) (362)
Quantitative Analysis of the Complex between p21 and the Ras-binding Domain of the Human Raf-1 Protein Kinase (*) (1995) (346)
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras (1997) (345)
Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor (1996) (338)
Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1. (1995) (328)
Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport (1999) (315)
Structural View of the Ran–Importin β Interaction at 2.3 Å Resolution (1999) (312)
GEFs and GAPs: Critical Elements in the Control of Small G Proteins (2007) (305)
Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins (2000) (302)
Structural view of a fungal toxin acting on a 14‐3‐3 regulatory complex (2003) (300)
The 1.7 Å crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller (1998) (297)
Dynamic properties of the Ras switch I region and its importance for binding to effectors (2001) (280)
A restricted spectrum of NRAS mutations causes Noonan syndrome (2010) (279)
The structure of Ras protein: a model for a universal molecular switch. (1991) (277)
It takes two to tango: regulation of G proteins by dimerization (2009) (277)
Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity (1992) (266)
Structural and mechanistic insights into the interaction between Rho and mammalian Dia (2005) (261)
A new family of RhoGEFs activates the Rop molecular switch in plants (2005) (246)
Structural Basis for Guanine Nucleotide Exchange on Ran by the Regulator of Chromosome Condensation (RCC1) (2001) (244)
The kinetic mechanism of Ran--nucleotide exchange catalyzed by RCC1. (1995) (243)
Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins (1995) (234)
Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product. (1990) (234)
Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm. (1998) (234)
Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras. (1993) (229)
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. (2011) (228)
Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy. (2007) (224)
Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide‐binding site. (1986) (217)
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins (2011) (212)
Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP. (1996) (212)
Ras/Rap effector specificity determined by charge reversal (1996) (204)
Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras·GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins (1996) (203)
Capturing cyclic nucleotides in action: snapshots from crystallographic studies (2007) (202)
RanGAP mediates GTP hydrolysis without an arginine finger (2002) (201)
Structure and regulation of the cAMP-binding domains of Epac2 (2003) (200)
The complex of Arl2‐GTP and PDEδ: from structure to function (2002) (197)
Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state (2006) (195)
ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons (1989) (193)
Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form (1995) (193)
GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins. (1997) (186)
How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP (2006) (184)
How Ras-related proteins talk to their effectors. (1996) (172)
Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras (1996) (170)
Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction. (1988) (170)
Nucleoside triphosphate-binding proteins: different scaffolds to achieve phosphoryl transfer (1999) (169)
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins (2012) (168)
Ligand-mediated Activation of the cAMP-responsive Guanine Nucleotide Exchange Factor Epac* (2003) (168)
Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase (2008) (165)
The regulation of mDia1 by autoinhibition and its release by Rho•GTP (2005) (165)
The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3 (2008) (164)
GTP-induced conformational changes in septins and implications for function (2009) (161)
Structural analysis of the GAP‐related domain from neurofibromin and its implications (1998) (157)
Phosphorylation‐independent interaction between 14‐3‐3 and exoenzyme S: from structure to pathogenesis (2007) (152)
Triphosphate structure of guanylate‐binding protein 1 and implications for nucleotide binding and GTPase mechanism (2000) (151)
Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1. (1998) (150)
The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization. (2004) (150)
The GTPase-activating protein Rap1GAP uses a catalytic asparagine (2004) (149)
Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo (1996) (145)
Ras-A Molecular Switch Involved in Tumor Formation. (2000) (145)
Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides (1994) (142)
Guanosine triphosphatase stimulation of oncogenic Ras mutants. (1999) (140)
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE (2002) (139)
Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements. (1995) (137)
RNA1 Encodes a GTPase-activating Protein Specific for Gsp1p, the Ran/TC4 Homologue of Saccharomyces cerevisiae(*) (1995) (134)
Structural Insights into HypB, a GTP-binding Protein That Regulates Metal Binding* (2006) (133)
A simplified procedure for the isolation of bacterial polypeptide elongation factor EF-Tu. (1980) (133)
RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein. (1996) (133)
The Cdc42/Rac Interactive Binding Region Motif of the Wiskott Aldrich Syndrome Protein (WASP) Is Necessary but Not Sufficient for Tight Binding to Cdc42 and Structure Formation* (1998) (133)
Transient kinetic studies on the interaction of Ras and the Ras-binding domain of c-Raf-1 reveal rapid equilibration of the complex. (1998) (131)
The interaction of Ras with GTPase‐activating proteins (1997) (130)
Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy. (1997) (129)
Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons (1993) (128)
PDZ-GEF1, a Guanine Nucleotide Exchange Factor Specific for Rap1 and Rap2* (1999) (127)
Bioorganic synthesis of lipid-modified proteins for the study of signal transduction (2000) (126)
Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study. (1994) (126)
Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders (2011) (122)
Signal transduction via Ras. (1998) (122)
Specificity of Interactions between mDia Isoforms and Rho Proteins* (2008) (121)
Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling (1997) (120)
The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. (2004) (119)
Structural view of the Ran-Importin beta interaction at 2.3 A resolution. (1999) (118)
Signaling mechanistics: Aluminum fluoride for molecule of the year (1997) (117)
How the Pseudomonas aeruginosa ExoS toxin downregulates Rac (2001) (117)
The Rap–RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues (2008) (117)
The crystal structure of rna1p: a new fold for a GTPase-activating protein. (1999) (117)
A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins (2015) (116)
Conformational Switch and Role of Phosphorylation in PAK Activation (2001) (116)
Lipidated ras and rab peptides and proteins--synthesis, structure, and function. (2006) (111)
Identification of pyrazolopyridazinones as PDEδ inhibitors (2016) (110)
Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time (2001) (108)
The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy (2008) (108)
Dimerisation‐dependent GTPase reaction of MnmE: how potassium acts as GTPase‐activating element (2006) (108)
Regulation of dynamic polarity switching in bacteria by a Ras-like G-protein and its cognate GAP (2010) (108)
The complex of Arl2-GTP and PDE delta: from structure to function. (2002) (104)
Structural relationships in the adenylate kinase family. (1986) (103)
Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N) (1997) (103)
Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes. (2010) (102)
Structural basis for Arl3‐specific release of myristoylated ciliary cargo from UNC119 (2012) (102)
Structure and function of Rho-type molecular switches in plants. (2008) (100)
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations (2012) (98)
Structural and biochemical analysis of Ras‐effector signaling via RalGDS (1999) (97)
Mutations in the nucleotide binding loop of adenylate kinase of Escherichia coli. (1988) (94)
Structural evidence for a common intermediate in small G protein-GEF reactions. (2007) (93)
C-terminal truncation of p21H preserves crucial kinetic and structural properties. (1989) (90)
p21 with a phenylalanine 28----leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties. (1991) (89)
Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity (2011) (87)
Structurally and catalytically important residues in the phosphate binding loop of adenylate kinase of Escherichia coli. (1990) (86)
Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. (2006) (85)
Ras‐effector interactions, the problem of specificity (1995) (85)
Mutations of Ha‐ras p21 that define important regions for the molecular mechanism of the SDC25 C‐domain, a guanine nucleotide dissociation stimulator. (1992) (84)
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2. (2003) (84)
Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH2p: implications for the interaction with effector proteins. (2005) (83)
Rap-specific GTPase Activating Protein follows an Alternative Mechanism* (2002) (83)
GAP1 Family Members Constitute Bifunctional Ras and Rap GTPase-activating Proteins* (2006) (82)
Interactions between Ras proteins and their effectors. (1996) (82)
Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb (2008) (82)
Effector Recognition by the Small GTP-binding Proteins Ras and Ral* (1999) (82)
Human OLA1 Defines an ATPase Subfamily in the Obg Family of GTP-binding Proteins* (2007) (81)
A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A. (2009) (78)
Is there a rate-limiting step before GTP cleavage by H-ras p21? (1991) (77)
Substrate and product structural requirements for binding of nucleotides to H-ras p21: the mechanism of discrimination between guanosine and adenosine nucleotides. (1995) (77)
Fluorescence and NMR investigations on the ligand binding properties of adenylate kinases. (1990) (77)
Modulation of NMDA Receptor— Dependent Calcium Influx and Gene Expression Through EphB Receptors (2002) (77)
The inhibition of the GTPase activating protein‐Ha‐ras interaction by acidic lipids is due to physical association of the C‐terminal domain of the GTPase activating protein with micellar structures. (1991) (77)
How does the switch II region of G‐domains work? (1993) (75)
Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein (1994) (73)
Structural Differences in the Minimal Catalytic Domains of the GTPase-activating Proteins p120GAP and Neurofibromin* (1996) (73)
The structure of the TrmE GTP‐binding protein and its implications for tRNA modification (2005) (73)
Synthesis of the Rheb and K-Ras4B GTPases. (2010) (71)
Thermodynamics of Ras/Effector and Cdc42/Effector Interactions Probed by Isothermal Titration Calorimetry* (2001) (71)
Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1. (2001) (71)
Preparation and characterization of nucleotide-free and metal ion-free p21 "apoprotein". (1987) (71)
Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3‐effector‐GAP complex (2008) (70)
Communication between the Regulatory and the Catalytic Region of the cAMP-responsive Guanine Nucleotide Exchange Factor Epac* (2003) (69)
Biochemical and biological consequences of changing the specificity of p21ras from guanosine to xanthosine nucleotides. (1996) (69)
Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras. (1996) (68)
A recombinant BBSome core complex and how it interacts with ciliary cargo (2017) (68)
Nucleotide binding and filament assembly of recombinant yeast septin complexes (2005) (67)
Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy (2004) (67)
A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein (2006) (67)
The Ras Mutant D119N Is Both Dominant Negative and Activated (1999) (66)
A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. (2017) (65)
The Structure of an Arf-ArfGAP Complex Reveals a Ca2+ Regulatory Mechanism (2010) (64)
PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity (2016) (64)
The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo (2013) (63)
Characterization of the GbpD-activated Rap1 Pathway Regulating Adhesion and Cell Polarity in Dictyostelium discoideum* (2006) (63)
Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta. (2000) (60)
Biochemical and crystallographic characterization of a complex of c-Ha-ras p21 and caged GTP with flash photolysis. (1989) (60)
Biochemical Characterization of the Ran-RanBP1-RanGAP System: Are RanBP Proteins and the Acidic Tail of RanGAP Required for the Ran-RanGAP GTPase Reaction? (2003) (59)
Unravelling the mechanism of dual‐specificity GAPs (2010) (58)
The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+. (1997) (57)
C2 domains as protein-protein interaction modules in the ciliary transition zone (2015) (57)
The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. (2001) (57)
Structural and biochemical properties show ARL3-GDP as a distinct GTP binding protein. (2000) (56)
Structural and biochemical properties of Sept7, a unique septin required for filament formation (2011) (56)
Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering (2016) (56)
Model of the ran-RCC1 interaction using biochemical and docking experiments. (1999) (55)
Dynamic and equilibrium studies on the interaction of Ran with its effector, RanBP1. (1997) (55)
Synthesis of functional Ras lipoproteins and fluorescent derivatives. (2001) (55)
X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp. (1995) (54)
Affinity of guanine nucleotide binding proteins for their ligands: facts and artefacts. (1991) (53)
Covalent Protein Labeling at Glutamic Acids. (2017) (53)
Rho proteins of plants--functional cycle and regulation of cytoskeletal dynamics. (2011) (53)
Regulation of Cdc2/cyclin B activation by Ran, a Ras-related GTPase. (1995) (52)
The RafC1 Cysteine-Rich Domain Contains Multiple Distinct Regulatory Epitopes Which Control Ras-Dependent Raf Activation (1998) (52)
Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate. (2008) (50)
Fluorescence methods in the study of small GTP-binding proteins. (2002) (50)
Human septin isoforms and the GDP-GTP cycle (2013) (50)
The elongation factor Tu binds aminoacyl-tRNA in the presence of GDP. (1982) (50)
Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway (2009) (49)
Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site. (2014) (48)
Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGAP interaction (2008) (47)
Elongation factor T from Bacillus stearothermophilus and Escherichia coli. Purification and some properties of EF-Tu and EF-Ts from Bacillus stearothermophilus. (1976) (47)
Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down. (2016) (47)
RalGEF2, a Pleckstrin Homology Domain Containing Guanine Nucleotide Exchange Factor for Ral* (2000) (47)
Simulation of the solution structure of the H-ras p21-GTP complex. (1992) (46)
Ras – ein molekularer Schalter bei der Tumorentstehung (2000) (46)
Intracellular distribution of β-catenin in colorectal adenomas, carcinomas and Peutz-Jeghers polyps (1999) (46)
Phosphoryl transfer in Ras proteins, conclusive or elusive? (2006) (45)
A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected]. (2010) (45)
Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1. (1999) (45)
GTP-Binding Proteins: Structures, interactions and relationships (1994) (43)
Guanine nucleotide binding properties of the mammalian RalA protein produced in Escherichia coli. (1990) (43)
Characterisation of the metal-ion-GDP complex at the active sites of transforming and nontransforming p21 proteins by observation of the 17O-Mn superhyperfine coupling and by kinetic methods. (1987) (43)
Characterization of cDNA coding for the complete light meromyosin portion of a rabbit fast skeletal muscle myosin heavy chain. (1987) (43)
Kissing G Domains of MnmE Monitored by X-Ray Crystallography and Pulse Electron Paramagnetic Resonance Spectroscopy (2009) (42)
Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf. (1998) (41)
Crystal Structure of the Human Retinitis Pigmentosa 2 Protein and Its Interaction with Arl 3 (41)
Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes (2012) (41)
Composition and properties of trypsin-cleaved elongation factor Tu. (1980) (40)
Expression of the GTPase activating domain of the neurofibromatosis type 1 (NF1) gene in Escherichia coli and role of the conserved lysine residue. (1992) (40)
G-domain dimerization orchestrates the tRNA wobble modification reaction in the MnmE/GidA complex. (2009) (39)
Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach. (2007) (38)
Crystallization and preliminary X-ray analysis of the human c-H-ras-oncogene product p21 complexed with GTP analogues. (1989) (38)
Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3* (2016) (38)
ADP ribosylation of Arg41 of Rap by ExoS inhibits the ability of Rap to interact with its guanine nucleotide exchange factor, C3G. (2001) (38)
Structural insights into the small G-protein Arl13B and implications for Joubert syndrome. (2014) (37)
Structure of the human BBSome core complex (2020) (37)
Structure of the metal-water complex in Ras x GDP studied by high-field EPR spectroscopy and 31P NMR spectroscopy. (2001) (37)
Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran. (1996) (35)
Studies on the structure and mechanism of H-ras p21. (1992) (35)
Nucleotide binding to the G12V‐mutant of Cdc42 investigated by X‐ray diffraction and fluorescence spectroscopy: Two different nucleotide states in one crystal (2008) (35)
Revisiting the Roco G-protein cycle. (2015) (35)
Crystals of partially trypsin-digested elongation factor Tu. (1976) (35)
Adenylate kinases from thermosensitive Escherichia coli strains. (1989) (33)
Predicted Incorporation of Non‐native Substrates by a Polyketide Synthase Yields Bioactive Natural Product Derivatives (2014) (33)
T cell epitopes encompassing the mutational hot spot position 61 of p21 ras. Promiscuity in ras peptide binding to HLA (1994) (33)
Chemoenzymatic Synthesis of Biotinylated Ras Peptides and Their Use in Membrane Binding Studies of Lipidated Model Proteins by Surface Plasmon Resonance (1999) (33)
Discriminatory Residues in Ras and Rap for Guanine Nucleotide Exchange Factor Recognition* (1999) (33)
Sorting of lipidated cargo by the Arl2/Arl3 system (2016) (33)
Discrimination of Amino Acids Mediating Ras Binding from Noninteracting Residues Affecting Raf Activation by Double Mutant Analysis* (1997) (32)
Stabilization of G Domain Conformations in the tRNA-modifying MnmE-GidA Complex Observed with Double Electron Electron Resonance Spectroscopy* (2010) (32)
Amino Acids of the Bacterial Toxin SopE Involved in G Nucleotide Exchange on Cdc42* (2003) (32)
The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex. (2008) (32)
Binding of the H-ras p21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p21 GTPase activity in vitro. (1992) (30)
Lipidierte Ras‐ und Rab‐Peptide und ‐Proteine: Synthese, Struktur und Funktion (2006) (30)
Conformational heterogeneity of the Roc domains in C. tepidum Roc–COR and implications for human LRRK2 Parkinson mutations (2015) (29)
Properties of the interaction of Arf-like protein 2 with PDEdelta. (2005) (29)
Structural Characterization of LRRK2 Inhibitors. (2015) (29)
Systematic Peptide Array-based Delineation of the Differential β-Catenin Interaction with Tcf4, E-Cadherin, and Adenomatous Polyposis Coli* (2005) (27)
RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP‐binding proteins and mediate Rap2‐specific nucleotide exchange (2009) (27)
Structural and catalytic role of arginine 88 in Escherichia coli adenylate kinase as evidenced by chemical modification and site-directed mutagenesis. (1989) (27)
The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins. (2008) (27)
The structure of transducin Gαt: More to view than just Ras (1994) (26)
Polymorphism in crystallin elongation factor Tu-GDP from Escherichia coli. (1976) (26)
Proton NMR studies of transforming and nontransforming H-ras p21 mutants. (1990) (25)
Fluorescently labelled guanine nucleotide binding proteins to analyse elementary steps of GAP-catalysed reactions. (2002) (25)
Actin filament bundling and different nucleating effects of mouse Diaphanous-related formin FH2 domains on actin/ADF and actin/cofilin complexes. (2010) (24)
The structure of the EF-Tu . GDP . Me2+ complex. (1982) (23)
Stereochemistry of the elongation factor Tu X GTP complex. (1983) (21)
Characterization of a novel RP2–OSTF1 interaction and its implication for actin remodelling (2018) (21)
Fourier Transform Infrared Spectroscopy on the Rap·RapGAP Reaction, GTPase Activation without an Arginine Finger* (2004) (21)
Nucleotide binding and filament assembly of recombinant yeast septin complexes. (2004) (21)
GTPase activity of Di-Ras proteins is stimulated by Rap1GAP proteins (2010) (20)
Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points. (1994) (20)
Mechanism and dynamics of INPP5E transport into and inside the ciliary compartment (2017) (19)
CHEMOENZYMATIC SYNTHESIS OF FLUORESCENT N-RAS LIPOPEPTIDES AND THEIR USE IN MEMBRANE LOCALIZATION STUDIES IN VIVO (1997) (19)
RPGR and RP2: targets for the treatment of X-linked retinitis pigmentosa? (2009) (19)
Ras P21 protein promotes survival and differentiation of human embryonic neural crest-derived cells (1996) (19)
The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function (2015) (19)
A Universal Expression–Purification System Based on the Coiled–Coil Interaction of Myosin Heavy Chain (1992) (18)
Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site. (2017) (18)
Structural requirements of the GDP binding site of elongation factor Tu (1977) (17)
Crystals of a large tryptic peptide (fragment A) of elongation factor EF‐Tu from Escherichia coli (1977) (17)
The unique plant RhoGAPs are dimeric and contain a CRIB motif required for affinity and specificity towards cognate small G proteins. (2011) (17)
P21ras Oncogene Protein Selectively Increases Low‐voltage‐activated Ca2+ Current Density in Embryonic Chick Dorsal Root Ganglion Neurons (1992) (17)
Ras proteins activate calcium channels in neuronal cells. (1991) (17)
Dimeric plant RhoGAPs are regulated by its CRIB effector motif to stimulate a sequential GTP hydrolysis. (2011) (16)
Oncogenic insertional mutations in the P-loop of Ras are overactive in MAP kinase signaling (2000) (16)
Kinetic and Structural Analysis of the Mg 2 +-binding Site of the Guanine Nucleotide-binding Protein p 21 Hras (2009) (16)
How to name atoms in phosphates, polyphosphates, their derivatives and mimics, and transition state analogues for enzyme-catalysed phosphoryl transfer reactions (IUPAC Recommendations 2016) (2017) (16)
Lipidated Ras and Rab Peptides and Proteins — Synthesis, Structure, and Function (2007) (16)
GTPase activity of small GTP-binding proteins in HL-60 membranes is stimulated by arachidonic acid. (1993) (16)
The N‐ and C‐terminal ends of RPGR can bind to PDE6δ (2015) (15)
Bacterial elongation factor Ts: isolation and reactivity with elongation factor Tu (1983) (15)
Spectroscopic and hydrodynamic studies reveal structural differences in normal and transforming H-ras gene products. (1988) (15)
Small-Molecule Inhibition of the UNC119-Cargo Interaction. (2017) (15)
Three-dimensional structure and properties of wild-type and mutant H-ras-encoded p21. (1993) (15)
Ras Superfamily Small G Proteins: Biology and Mechanisms 1 (2014) (14)
Stabilisierung eines niederaffinen Zustands für Effektoren im menschlichen Ras-Protein durch Cyclenkomplexe (2010) (14)
Synthese der Schafinsulin-A-Kette mit 6–11-Disulfidring. I (1974) (14)
Time-resolved crystallography on H-ras p21 (1992) (14)
Structural basis for Arl 3-specific release of myristoylated ciliary cargo from UNC 119 (2012) (13)
Structural and catalytic properties of a deletion derivative (delta 133-157) of Escherichia coli adenylate kinase. (1991) (13)
The effect of Mg2+ on some properties of nucleotide-free elongation factor Tu from Bacillus stearothermophilus. (1979) (13)
Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3. (2015) (13)
Proton NMR studies of the GDP.Mg2+ complex of the Ha-ras oncogene product p21. (1988) (13)
Structures of nuclear transport components (1999) (13)
The purification and crystallization of mDia1 in complex with RhoC. (2005) (13)
Structure-based development of PDEδ inhibitors (2017) (12)
Structural and Mechanistic Aspects of the GTPase Reaction of H-ras p21 (1993) (12)
Expression, purification and biochemical characterisation of the human immunodeficiency virus 1 nef gene product. (1992) (12)
A Receptor-associated Protein/Phosphatidylinositol 3-Kinase Pathway Controls Pseudopod Formation (2010) (12)
Biochemical and kinetic properties of the complex Roco G-protein cycle (2018) (12)
Crystallization and preliminary X‐ray crystallographic study of the Ras‐GTPase‐activating domain of human p120GAP (1997) (12)
31P-NMR spectra of the Ha-ras p21.nucleotide complexes. (1986) (12)
An efficient expression vector (pPLEX) for bacterial synthesis of non-fusion proteins and protein domains. (1987) (12)
C-TERMINAL STRUCTURE AND MOBILITY OF RABBIT SKELETAL-MUSCLE LIGHT-MEROMYOSIN AS STUDIED BY ONE-DIMENSIONAL AND 2-DIMENSIONAL1H NMR SPECTROSCOPY AND X-RAY SMALL-ANGLE SCATTERING (1991) (11)
Ras Superfamily Small G Proteins: Biology and Mechanisms 2 (2014) (11)
The actin filament architecture: tightly regulated by the cells, manipulated by pathogens (2002) (10)
Switching to Rac and Rho. (1995) (10)
Chemoenzymatische Synthese fluoreszierender N‐Ras‐Lipopeptide und ihre Verwendung bei In‐vivo‐Studien zur Membranlokalisierung (1997) (10)
Letter to the Editor: Sequential NMR assignment of the RAS-binding domain of Byr2 (2000) (10)
Sequence of the myosin light chain 1/3 isolated from a rabbit fast skeletal muscle lambda library. (1990) (10)
Electron-paramagnetic-resonance studies of manganese(II) complexes with elongation factor Tu from Bacillus stearothermophilus. Observation of a GTP hydrolysis intermediate state complex. (1984) (10)
Sequence of two isoforms of myosin light chain 2 isolated from a rabbit fast skeletal muscle lambda library. (1990) (9)
GTP and ATP hydrolysis in biology (2016) (9)
Crystallization and preliminary X‐ray analysis of UMP/CMP‐kinase from Dictyostelium discoideum with the specific bisubstrate inhibitor P1‐(adenosine 5′)‐P5‐(uridine 5′)‐pentaphosphate (UP5A) (1995) (9)
Fluorescence and NMR investigations on the ligand binding properties of adenylate kinases [Erratum to document cited in CA113(9):73603k] (1990) (8)
Deciphering the alphabet of G proteins: the structure of the α, β, γ heterotrimer (1996) (8)
The Structure of an Arf-ArfGAP Complex Reveals a Ca2+ Regulatory Mechanism (2010) (8)
Structure of the human BBSome core complex in the open conformation (2019) (7)
Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation. (1999) (7)
The binding of nucleotides and metal ions to elongation factor Tu from Bacillus stearothermophilus as studied by equilibrium dialysis. (1981) (7)
New N-2-labelled fluorescent derivatives of guanosine nucleotides and their interaction with GTP-binding proteins (1999) (7)
Purification and crystallization of the catalytic PRONE domain of RopGEF8 and its complex with Rop4 from Arabidopsis thaliana. (2006) (7)
Priming of PC12 cells for semiquantitative microinjection studies involving Ras (2000) (7)
Obg, a G domain with a beautiful extension. (2002) (7)
Polyphenylalanine synthesis by crystallized trypsin-modified EF-Tu.GDP. (1979) (6)
Purification, crystallization and preliminary structural characterization of human Rap1GAP. (2004) (6)
STRUCTURE OF HUMAN GUANYLATE BINDING PROTEIN-1 IN NUCLEOTIDE FREE FORM (2000) (6)
Stereochemistry and lifetime of the GTP hydrolysis intermediate at the active site of elongation factor Tu from Bacillus stearothermophilus as inferred from the 17O-55Mn superhyperfine interaction. (1990) (6)
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice. (1992) (5)
Proton-nuclear magnetic resonance studies of the aromatic spin systems of Escherichia coli adenylate kinase. (1988) (5)
Synthesis of GTP‐Derived Ras Ligands (2004) (5)
From EF-Tu to P21ras and back again (1993) (4)
STRUCTURE DETERMINATION OF THE RAS-BINDING DOMAIN OF THE RAL-SPECIFIC GUANINE NUCLEOTIDE EXCHANGE FACTOR RLF, NMR, 10 STRUCTURES (1999) (4)
Crystal structure of THEP1 from the hyperthermophile Aquifex aeolicus: a variation of the RecA fold (2005) (4)
Pictures in cell biology. Structures of nuclear-transport components. (1999) (4)
Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase (2013) (4)
Biosynthesis-driven structure-activity relationship study of premonensin-derivatives. (2016) (4)
Highlight: GTP Binding Proteins Central Regulators in Cell Biology (2000) (4)
Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells. (2019) (4)
31P NMR studies on ATP.Mg2+p21−nucleotide complexes. Chemical shifts, rate and equilibrium constants (1986) (3)
Das humane Guanylat-bindende Protein 1: Modell oder Sonderfall der Dynamin-verwandten GTP-bindenden Proteine. (2001) (3)
Identification of valine/leucine/isoleucine and threonine/alanine/glycine proton-spin systems of Escherichia coli adenylate kinase by selective deuteration and selective protonation. (1991) (3)
Structural studies on mammalian septins - New insights into filament formation (2007) (3)
RAS-RASGAP COMPLEX (1998) (3)
Domain topology of human Rasal (2017) (3)
How to switch a master switch (2013) (3)
Untersuchung von Ras/Effektor-Komplexen mit gezielt veränderten elektrostatischen Eigenschaften (2003) (3)
A sulphydryl group is not essential for the binding of GDP to elongation factor Tu (1979) (3)
The effect of kirromycin on the metal ion coordination in complexes of elongation factor Tu from Bacillus stearothermophilus as inferred from the 17O-55Mn superhyperfine interaction. (1991) (2)
Funktionelle und strukturelle Charakterisierung von Ras-Effektoren: Eigenschaften des kleinen Ras-Effektors Novel Ras Effector 1 (Nore1) (2003) (2)
Ras - A Molecular Switch Involved in Tumor Formation. (2001) (2)
31P-NMR studies on ATP X Mg2+, p21 X nucleotide, and adenylate kinase X nucleotide complexes. Chemical shifts, rate and equilibrium constants. (1986) (2)
The structure of transducin G alpha t: more to view than just ras. (1994) (2)
The regulation of mDia 1 by autoinhibition and its release by Rho K GTP (2013) (2)
Author response: Structure of the human BBSome core complex (2020) (2)
Deciphering the alphabet of G proteins: the structure of the alpha, beta, gamma heterotrimer. (1996) (1)
Complex of Arl2 and PDE delta, Crystal Form 2 (SeMet) (2002) (1)
FTIR on the Rap-RapGAP reaction: GTPase activation without an arginine finger (2004) (1)
THE GAP RELATED DOMAIN OF NEUROFIBROMIN (1999) (1)
Structural And Functional Studies on c-P21, v-P21 and the Genetically Engineered Guanine Nucleotide Binding Domain of EF-Tu (1989) (1)
Biochemical and crystallographic characterization of a complex of cHaras p 21 and caged GTP with flash photolysis ( time-resolved structure ) (1)
Molecular Dynamics Studies of H-ras p21-GTP (1993) (1)
The 2.66 angstrom crystal structure of Rna1 reveals a new fold for a GTPase Activating Protein (1999) (1)
Characterization of a novel RP 2-OSTF 1 interaction and its implication for actin remodeling (2018) (1)
Faculty Opinions recommendation of Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain. (2005) (1)
Charakterisierung und Stabilisierung von 14-3-3-Protein-Protein- Wechselwirkungen (2012) (1)
Preparation and Characterization of Nucleotide-free and Metal Ion- (1987) (1)
Strukturelle und funktionelle Charakterisierung neuartiger Guaninnukleotid-Austauschfaktoren der Rho-Proteine aus Pflanzen (2007) (1)
C-terminal structure and mobility of rabbit skeletal muscle light meromyosin as studied by one- and two-dimensional 1H NMR spectroscopy and X-ray small-angle scattering. (1991) (1)
Kinetic and Structural Analysis of the Mg 2 +-binding Site of the Guanine Nucleotide-binding Protein p 2 lH + = * (2001) (1)
Strukturelle Studien zur Wechselwirkung humaner Rho-Proteine mit Effektoren und Regulatoren (2002) (1)
CHAPTER 247 – Structural Considerations of Small GTP-Binding Proteins (2003) (1)
Faculty Opinions recommendation of A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. (2002) (0)
The switch cycle of the Ras protein and its role in signal transduction (1997) (0)
Heterologous Expression and Characterization of the human Nod2 Protein (2008) (0)
Crystal structure of HypB from Methanocaldococcus jannaschii in the triphosphate form (2006) (0)
Faculty Opinions recommendation of Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. (2006) (0)
Cover picture (2007) (0)
Structure of fully modified farnesylated Rheb in complex with PDE6D (2011) (0)
MglA bound to GDP (2011) (0)
human VASP tetramerisation domain L352M (2004) (0)
Charakterisierung des MnmE-Homodimers durch Elektronenspinresonanz-Spektroskopie (2008) (0)
Kommunikation zwischen Signalwegen: Regulatoren und Effektoren von G Proteinen der RAS-Superfamilie (2009) (0)
Biochemische Charakterisierung der Interaktion des Transkriptionselongationsfaktors P-TEFb mit dem Inhibitorprotein Hexim 1 und der 7SK snRNA (2005) (0)
Screening-verfahren zum nachweis von reversiblen protein-protein wechselwirkungen (2001) (0)
Biochemische und Strukturelle Untersuchung der kleinen GTPasen ARL2 und ARL3 und ihrem Effektor PDEδ aus den Stäbchen der Mäuseretina (2001) (0)
Biochemische Charakterisierung eines GTPase-aktivierenden Proteins aus Arabidopsis thaliana (2008) (0)
Kristallographische und biochemische Untersuchungen zum Proteinkomplex Ran.RanBP1.RanGAP (2002) (0)
Analyse von Struktur-Funktionsbeziehungen bei der Ras-abhängigen Raf-Aktivierung (2002) (0)
Author response: A recombinant BBSome core complex and how it interacts with ciliary cargo (2017) (0)
Struktur-Funktions-Beziehungen der humanen Septine (2012) (0)
Strukturbiologie der Toxine ExoS und Fusicoccin. Wie zwei pathogene Organismen in die Biochemie der Zell-Regulation höherer Eukaryonten eingreifen (2003) (0)
Biochemische Untersuchung von Septinen aus Saccharomyces cerevisiae (2002) (0)
Modulare Elemente in den Signaltransduktionswegen kleiner GTPasen (2005) (0)
Strukturelle und biochemische Charakterisierung des Arl3-RP2-Signalkomplexes und weiterer Interaktionen von Arl2 und Arl3 (2008) (0)
Strukturelle und biochemische Charakterisierung prokaryotischer Roco-Proteine (2009) (0)
Biochemische Charakterisierung von Septin-Komplexen (2008) (0)
GTPase-Aktivierung in onkogenem Ras durch kleine Peptide. Assay des Zerfalls von radioaktiv gelabeltem γ-32P-GTP (2006) (0)
Struktur-Funktionsbeziehungen der Rho- und der Plexin-Proteinfamilien (2005) (0)
Untersuchung der Regulation von Rin durch kleine G- Proteine (2008) (0)
Struktur und Funktion der GTPase HypB (2005) (0)
Wege zur Inaktivierung von Onkoproteinen : die GTPase-Reaktion von Ras und Protein-Protein-Interaktionen von β-Catenin als Ansatzpunkte (2003) (0)
Biochemische und strukturelle Untersuchungen zur Funktion des an der Modifikation von tRNA beteiligten Guaninnukleotid-bindenden Proteins MnmE (2006) (0)
Genexpressionsanalysen genotoxischer und karzinogener Effekte an Primärzellen & Charakterisierung der Interaktion der isoprenoid-sensitiven Phosphodiesteraseδ und des semisynthetischen N-Ras Lipoproteins (2008) (0)
Chronologie der Wnt-Zielgenexpression und Visualisierung des nukleären β-Catenin/TCF-Komplexes (2007) (0)
Struktur-Funktionsbeziehungen bei der Regulation der RopGEF-vermittelten Aktivierung von Rho-Proteinen in Pflanzen (ROPs) (2011) (0)
Zellbiologische und biochemische Untersuchung von humanem Arl13B (2013) (0)
Bioinformatische Untersuchungen zur Erkennung und Klassifizierung von GTP-bindenden Proteinen (2002) (0)
Mechanismen der Signalübertragung durch PKC und Rho in Hefe und Säugern (2003) (0)
Strukturelle und biochemische Analyse von PAS-Domänen Interaktionen in den Uhrenproteinen Drosophila PERIOD und Maus PERIOD2 (2008) (0)
Strukturelle und biochemische Untersuchungen zur Interaktion zwischen dem Formin mDia1 und Rho-Proteinen (2005) (0)
Charakterisierung eines Rop-Proteins aus Arabidopsis thaliana und seiner Interaktionspartner (2005) (0)
Untersuchung der GTP-bindenden Proteine Arl2, Arl3 und der tubulinfaltenden Cofaktoren in Saccharomyes cerevisiae (2006) (0)
Charakterisierung der komplexbildenden Hydrogenase-akzessorischen Proteine HypA und HypB (2009) (0)
Strukturelle und biophysikalische Untersuchungen der regulatorischen Domäne von humanem Nalp1 (2012) (0)
Semisynthetische Ras-Lipoproteine : Studium der intrazellulären Lokalisation, biologischen Aktivität und Membranassoziation (2003) (0)
Strukturelle und biochemische Charakterisierung von Guaninnukleotid-bindenden Proteinen der Roco-Familie (2009) (0)
Strukturelle und funktionelle Charakterisierung der tRNA-modifizierenden Proteine MnmE und GidA (2010) (0)
Regulation des Formins mDia1 durch das kleine G-Protein Rho (2006) (0)
Untersuchung von Protein-Protein-Interaktionen in der Ras-vermittelten Signaltransduktion mittels bimolekularer Fluoreszenzkomplementation (2008) (0)
Nachrichten des Verbandes Biologie, Biowissenschaften & Biomedizin in Deutschland (2008) (0)
Isolierung und Charakterisierung prokaryotischer, Guaninnukleotid-bindender Proteine der Roco-Familie (2007) (0)
Biochemische und strukturelle Untersuchungen zum autoinhibitorischen Mechanismus des rho-Effektors mDia1 (2006) (0)
Biochemische Charakterisierung unkonventioneller Guaninnukleotid-bindender Proteine (2002) (0)
Identifizierung und Charakterisierung von ROP-Effektoren und ihren Interaktionspartnern beim polaren Zellwachstum in Pflanzen (2010) (0)
Strukturelle Aspekte der Rho-Familie und ihrer Interaktionspartner (2002) (0)
Die Rolle von Rho GTPasen bei der X-chromosomalen mentalen Retardation (2002) (0)
Röntgenkristallographische Strukturaufklärung des Proteins THEP1 aus Aquifex aeolicus (2004) (0)
Biochemische Charakterisierung neuartiger GTPase aktivierender Proteine der Rho-Familie aus Pflanzen (2009) (0)
PEPTIDE 97. MITT. SYNTHESE DER SCHAFINSULIN-A-KETTE MIT 6-11-DISULFIDRING 1. MITT. (1974) (0)
Strukturelle und funktionelle Analyse des Photorezeptormechanismus der Insekten CRYPTOCHROME sowie der PAS-Domänen Interaktionen der Uhrenproteine Maus PERIOD 1 und 3 (2010) (0)
SH1 von Polypeptide Elongationsfaktor Tu ist nicht essentiell für die bindung von GDP (1979) (0)
The Crystal structure of Arl2GppNHp in complex with UNC119a (2012) (0)
Faculty Opinions recommendation of Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells. (2001) (0)
Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A (2009) (0)
The Difference in Arl2 and Arl3 Membrane Binding and Localization (2015) (0)
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE GEF DOMAIN OF THE SALMONELLA TYPHIMURIUM SOPE TOXIN AND HUMAN Cdc42 (2002) (0)
Structure of Fully modified farnesylated INPP5E Peptide in complex with PDE6D (2011) (0)
Crystallographic studies of the nuclear pore (2009) (0)
Biochemical Characterization of the GTPase-activating protein GAP1IP4BP (2008) (0)
Solution structure of the Ran binding domain 2 from RanBP2 and its interaction with Ran (2004) (0)
Biochemical and Structural Characterization of Roco4. A Model to understand LRRK2 mediated Parkinsons disease. (2014) (0)
Humanized Roco4 bound to LRRK2-In1 (2015) (0)
The Crystal structure of PDE6D in complex with the inhibitor (s)-5 (2013) (0)
The crystal structure of ASAP3 in complex with Arf6 in transition state soaked with Calcium (2010) (0)
STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX (1999) (0)
The crystal structure of ASAP3 in complex with Arf6 in transition state (2010) (0)
CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF EPAC2 (2002) (0)
Faculty Opinions recommendation of Kinetic studies of the Arf activator Arno on model membranes in the presence of Arf effectors suggest control by a positive feedback loop. (2011) (0)
Crystal structure of the complex between the GAP domain of the Pseudomonas aeruginosa ExoS toxin and human Rac (2001) (0)
Crystal structure of C-terminally truncated Arl13B from Chlamydomonas rheinhardtii bound to GppNHp (2013) (0)
Mechanism of nucleotide binding and hydrolysis of human guanylate binding protein 1 (hGBP1) (1999) (0)
RAS Binding Compounds (2002) (0)
THE GTPASE REACTION OF RAS (1997) (0)
Roco proteins belong to the GAD class of molecular switches (2014) (0)
Crystal structure of Septin 2 in complex with GppNHp and Mg2 (2009) (0)
Crystal structure of MnmE from Chlorobium tepidum in complex with GCP (2009) (0)
Table of Contents (1991) (0)
Crystal structure of MDIA1-TSH GBD-FH3 in complex with CDC42-GMPPNP (2008) (0)
Structure of the MnmE G-domain in complex with GDP*AlF4-, Mg2+ and NH4+ (2006) (0)
A Multi-Pronged Approach for Uncovering Allosteric Networks in Caspases (2015) (0)
G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM (1999) (0)
MglA in complex with MglB in transition state (2011) (0)
University of Groningen Characterization of the GbpD-activated Rap1 Pathway Regulating Adhesion and Cell Polarity in Dictyostelium discoideum Kortholt, (2006) (0)
The crystal structure of the RPGR RCC1-like domain (2013) (0)
Structure of the Rap-RapGAP complex (2008) (0)
In vivo quantitative assessment of Ras/Raf interaction using the two-hybrid system (1997) (0)
Small Molecule Inhibition of Lipidated Proteins/Cargo Interaction and Synthesis of a Cinchona Alkaloid-derived Library as potent Autophagy Inhibitors (2017) (0)
Faculty Opinions recommendation of RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. (2003) (0)
Crystal structure of Ran-GPPNHP-RanBP1-RanGAP complex (2002) (0)
Crystal Structure of the Rap1GAP catalytic domain (2004) (0)
Table of Contents (1992) (0)
Crystal structure of MnmE from Chlorobium tepidum in complex with GDP and FOLINIC ACID (2009) (0)
H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP (1999) (0)
Faculty Opinions recommendation of Molecular basis for G protein control of the prokaryotic ATP sulfurylase. (2006) (0)
Structural and Biochemical Characterization of Roco Proteins from Dictyostelium discoideum (2012) (0)
Structural insights into the Roco G-protein cycle (2018) (0)
3D-STRUCTURE AND PROPERTIES OF WILDTYPE AND MUTANT H-RAS ENCODED P21 (1991) (0)
Structural Considerations of Small GTP-Binding Proteins (2010) (0)
Structure of the GTP-binding protein TrmE from Thermotoga maritima (2005) (0)
Fourier Transform Infrared Spectroscopy on the Rap (cid:1) RapGAP Reaction, GTPase Activation without an Arginine Finger* □ S (2004) (0)
Cell-based studies of ciliary transport (2018) (0)
Einfluss des Guaninnukleotid-bindenden Proteins TrmE auf die Modifikationsreaktion der Uridinbase in Wobble-Position von tRNA (2004) (0)
Faculty Opinions recommendation of Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. (2008) (0)
Localisation of fluorescently labelled Ras protein in the living cell (2002) (0)
Crystal Structure of the human Retinitis Pigmentosa protein 2 (RP2) (2006) (0)
Invited lecture: GTP-binding proteins of the ras subfamily and diseases (2006) (0)
Biochemical and Structural Analysis of the Chaperone-Assisted BBSome Assembly (2015) (0)
New N‐2‐Labelled Fluorescent Derivatives of Guanosine Nucleotides and Their Interaction with GTP‐Binding Proteins. (1999) (0)
Complex of Arl2 and PDE delta, Crystal Form 1 (2002) (0)
The crystal structure of PDE6D in complex to Deltasonamide1 (2017) (0)
Crystal Structure of the Roco4 Kinase Domain from D. discoideum (2012) (0)
The three-dimensional structures of the G/2D mutant and of the native complex with the unceptide analog mant-GppNP (1992) (0)
Biochemische Charakterisierung des Guaninnukleotid-bindenden 50 K/TrmE-Proteins aus E. coli (2002) (0)
Structural basis for the activation of the nuclear GTPase Ran by its β-propeller exchange factor RCC1 (2000) (0)
RAN-RCC1-SO4 COMPLEX (2001) (0)
Crystal structure of GidA from E. coli (2008) (0)
The crystal structure of a nucleotide exchange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like behaviour of the signalling protein Ras. (2013) (0)
COMPLEX OF RAN WITH IMPORTIN BETA (1999) (0)
MglA bound to GppNHp in complex with MglB (2011) (0)
Regulation of Epac by cAMP Regulatie (2003) (0)
TrmE, a GNBP involved in tRNA-modification (2004) (0)
Corrigendum to “The Role of the Conserved Switch II Glutamate in GEF-Mediated Nucleotide Exchange of GTP-Binding Proteins” [J. Mol. Biol. 379/1 (2008) 51–63] (2011) (0)
The crystal structure of myristoylated NPHP3 peptide in complex with UNC119a (2016) (0)
RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP (1997) (0)
SH1 OF POLYPEPTIDE ELONGATION-FACTOR IS NOT ESSENTIAL FOR GPD BINDING (1979) (0)
REGULATOR OF CHROMOSOME CONDENSATION (RCC1) OF HUMAN (1999) (0)
The crystal structure of PDEd in complex with inhibitor-2a (2016) (0)
ISOLATION OF ELONGATION-FACTORS FROM THE THERMOPHILIC BACTERIUM-PS3 (1979) (0)
The crystal structure of PDE6D in complex with rac-S1 (2013) (0)
Crystal structure of the ternary complex of 14-3-3n to design new herbicidal (2004) (0)
Crystal structure of the RP2-Arl3 complex bound to GppNHp (2008) (0)
Faculty Opinions recommendation of Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. (2013) (0)
BART-like domain of BARTL1/CCDC104 aa1-133 in complex with Arl3FL bound to GppNHp in P1 21 1 (2016) (0)
Complex of Ras with cyclen (2011) (0)
Proteins - from little acorns mighty oak trees grow - Editorial overview (2002) (0)
Faculty Opinions recommendation of G domain dimerization controls dynamin's assembly-stimulated GTPase activity. (2010) (0)
Highlight on septins (2011) (0)
Novel types of interactions of the small GTPase Ran with its effectors (2000) (0)
memB, a progression marker of human melanoma cell lines, encodes a new, atypical member of the Rho-family of GTPases (1997) (0)
The crystal structure of PDE6D in complex with inhibitor-3 (2017) (0)
CRYSTAL STRUCTURE OF MURINE ARL3-GDP (2000) (0)
Chemoenzymatic Synthesis of Fluorescent N‐Ras Lipopeptides and Their Use in Membrane Localization Studies in vivo. (1998) (0)
Crystal structure of HypB from Methanocaldococcus jannaschii in the triphosphate form, in complex with zinc (2006) (0)
The structure of the translation factor EF-Tu bound to a GTP analogue has recently been solved and sheds light on the function of many regulatory guanine nucleotide-binding proteins. (1993) (0)
Table of Contents (1990) (0)
Structural and functional analysis of the GTPase Activating Protein of the small guanine nucleotide binding protein Rap1 (2004) (0)
Biochemical and biophysical analysis of the GTPase activating proteins of the small guanine nucleotide binding protein Rap1 and RheB (2005) (0)
RocCOR domain tandem of Rab family protein (Roco) (2008) (0)
The crystal structure of inhibitor-15 covalently bound to PDE6D (2017) (0)
Crystal structure of Sept2 G-domain (2007) (0)
Structure of the 14-3-3 / H+-ATPase plant complex (2007) (0)
Abstract IA01: Ras membrane localization, ciliary trafficking and anti-Ras drug candidates (2014) (0)
Crystal structure of Septin 7 in complex with GDP (2011) (0)
human VASP tetramerisation domain (2004) (0)
Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with non-hydrolysable GTP analogue GppNHp (2006) (0)
The crystal structure of the RPGR RCC1-like domain in complex with PDE6D (2013) (0)
Chemotaxis: a complex network of interconnecting pathways and amplification loops (2003) (0)
Crystal structure of Ras-Bry2RBD complex (2002) (0)
The N- and C-terminal ends of RPGR can bind to PDE 6 d (2015) (0)
Crystal structure of GidA from Chlorobium tepidum (2008) (0)
Biochemical analysis of the Roco proteins GbpC and Roco4 (2010) (0)
Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D (2015) (0)
MglB with tetrameric arrangement (2011) (0)
Vav Guanine Nucleotide Exchange Proteint (0)
COR domain of Rab family protein (Roco) (2008) (0)
Crystal Structure of the L1180T mutant Roco4 Kinase Domain from D. discoideum bound to AppCp (2012) (0)
Crystal Structure of the G1179S Roco4 Kinase Domain bound to AppCp from D. discoideum. (2012) (0)
Crystal structure of Arl13B in complex with Arl3 of Chlamydomonas reinhardtii (2015) (0)
Signal transduction via small GTP-binding proteins - Ras as a paradigm. 1. Mechanisms of the molecular switch, the Turn-ON and Turn-OFF reaction (2000) (0)
Crystal structure of the core FH2 domain of mouse mDia1 (2004) (0)
The Crystal Structure of full length Arl3GppNHp in complex with UNC119a (2012) (0)
How GAP pulls the trigger on the GTPase of Ras (1998) (0)
Crystal Structure of H-Ras with Thr50 replaced by Isoleucine (2009) (0)
HUMAN GUANYLATE BINDING PROTEIN-1 IN COMPLEX WITH THE GTP ANALOGUE, GMPPNP. (2000) (0)
C-H-RAS P21 PROTEIN MUTANT WITH THR 35 REPLACED BY SER (T35S) COMPLEXED WITH GUANOSINE-5'-[B,G-IMIDO] TRIPHOSPHATE (2001) (0)
Are GTP-analogs really good analogs? (2002) (0)
Structural and biochemical characterisation of the Rho effector mDia (2004) (0)
Faculty Opinions recommendation of Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature. (2004) (0)
Identification of regions in human guanylate binding protein 1 (hGBP1) responsible for oligomerization and GTPase activity (2000) (0)
Crystal structure of the RP2-Arl3 complex bound to GDP-AlF4 (2008) (0)
MglB R124A E127A Monomer (2011) (0)
Crystal structure of the N-terminal mDia1 Armadillo Repeat Region and Dimerisation Domain in complex with the mDia1 autoregulatory domain (DAD) (2006) (0)
Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with GMP (2006) (0)
Mutational, structural and dynamic analysis of the Ran-RanBP2 interaction in nucleo-cytoplasmic transport (2002) (0)
Diverse mechanims for GTP hydrolysis by GTP-binding proteins (2002) (0)
A de-/reacylation cycle controls the localisation and compartmentalised activity of palmitoylated Ras (2005) (0)
Tucker, J. et al. Expression of p21 proteins in Escherichia coli and stereochemistry of th nucleotide-binding site. EMBO J. 5, 1351-1358 (1986) (0)
Proteins special issue of biopolymers (2013) (0)
Faculty Opinions recommendation of Cocrystal structure of a tRNA Psi55 pseudouridine synthase: nucleotide flipping by an RNA-modifying enzyme. (2002) (0)
Signal transduction via small GTP-binding proteins - Ras as a paradigm. 2. Interaction with effectors (2000) (0)
Faculty Opinions recommendation of Insights into translational termination from the structure of RF2 bound to the ribosome. (2009) (0)
Complex of Arl2 and PDE delta, Crystal Form 2 (native) (2002) (0)
Crystal Structure of THEP1 from the hyperthermophile Aquifex aeolicus (2005) (0)
Crystal Structure of the Roco4 Kinase Domain from D. discoideum bound to the ROCK Inhibitor H1152 (2012) (0)
Crystal structure of PDE6D in complex with the inhibitor rac-2 (2013) (0)
The Crystal structure of Chlamydomonas reinhardtii Arl3 bound to GppNHp (2016) (0)
RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES (1998) (0)
Faculty Opinions recommendation of A general amphipathic alpha-helical motif for sensing membrane curvature. (2007) (0)
Towards the function of plant Rop GTPases in actin reorganisation (2004) (0)
Faculty Opinions recommendation of The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction. (2003) (0)
Regulation of Epac by cAMP (2003) (0)
Functional analysis of the GTPase-activating protein GAP1IP4BP (2004) (0)
THE ELONGATION-FACTOR TU BINDS AMINOACYL-TRANSFER RNA IN THE PRESENCE OF GDP (1982) (0)
Structure of the GTP-binding protein TrmE from Thermotoga maritima complexed with 5-formyl-THF (2005) (0)
Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP (2005) (0)
Humanized Roco4 bound to Compound 19 (2015) (0)
The GTPase switch: a familiar, conserved module with unexpected variations (2002) (0)
Recently available crystal structures show that some, though not all, GTP-binding proteins have a common 'G-domain' topology, variations on which confer distinct functional properties. (1994) (0)
General features, signaling (2014) (0)
Crystal structure of Ran-GDP-AlFx-RanBP1-RanGAP complex (2002) (0)
HUMAN RAP1A, RESIDUES 1-167, DOUBLE MUTANT (E30D,K31E) COMPLEXED WITH GPPNHP AND THE RAS-BINDING-DOMAIN OF HUMAN C-RAF1, RESIDUES 51-131 (1997) (0)
Crystal structure of the GAP domain of the Pseudomonas aeruginosa ExoS toxin (2001) (0)
Crystal structure of MnmE from Nostoc in complex with GDP, FOLINIC ACID and ZN (2009) (0)
Leucine rich repeat domain of the Chlorobium tepidum Roco protein (2016) (0)
[Pierre Chardin, a pioneer in the discovery of the genes and proteins of the Ras superfamily]. (2020) (0)
Screening for functional 'GAPettes' directed against constitutively activated Ras proteins (2009) (0)
The Ras-RasGAP complex: How to complement an inefficient active site (1999) (0)
Faculty Opinions recommendation of Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. (2004) (0)
Crystal-structure of the N-terminal Large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with GDP/AlF3 (2006) (0)
MglA bound to GDP in P2(1) tetrameric arrangement (2011) (0)
Structural Views of the Ran GTPase Cycle (2001) (0)
Crystal Structure of the RPGR RCC1-like domain in complex with the RPGR-interacting domain of RPGRIP1 (2014) (0)
Faculty Opinions recommendation of Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex. (2001) (0)
H-Ras wildtype new crystal form (2011) (0)
BART-like domain of BARTL1/CCDC104 in complex with Arl3FL bound to GppNHp in P21 21 21 (2015) (0)
H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MAGNESIUM (1997) (0)
Structural and Mechanistic Studies on Ran (2000) (0)

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