Ali Shilatifard
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American biochemist/molecular biologist
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Why Is Ali Shilatifard Influential?
(Suggest an Edit or Addition)According to Wikipedia, Ali Shilatifard is an American biochemist/molecular biologist, the Robert Francis Furchgott Professor and chairman of the department of biochemistry and molecular genetics, and the director of the Simpson Query Institute for Epigenetics at the Northwestern University Feinberg School of Medicine. He has served as a senior editor for the journal Science, and currently serves as the Editor for Science's open access journal Science Advances. Research in Shilatifard's lab focuses on the cause of childhood leukemia through chromosomal translocations, the role of ELL in this process, and the discovery of the Super Elongation Complex as being a central complex linking MLL translocations into a diverse number of genes to leukemic pathogenesis. He is an elected fellow of the American Association for the Advancement of Science , and elected member of American Academy of Arts & Sciences .
Ali Shilatifard's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Global landscape of protein complexes in the yeast Saccharomyces cerevisiae (2006) (2968)
- An operational definition of epigenetics. (2009) (1627)
- Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. (2006) (1137)
- New Nomenclature for Chromatin-Modifying Enzymes (2007) (904)
- The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. (2012) (873)
- The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. (2003) (762)
- Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. (2003) (727)
- Methylation of Histone H3 by Set2 in Saccharomyces cerevisiae Is Linked to Transcriptional Elongation by RNA Polymerase II (2003) (707)
- Histone H2B Monoubiquitination Functions Cooperatively with FACT to Regulate Elongation by RNA Polymerase II (2006) (691)
- Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis (2019) (679)
- Covalent modifications of histones during development and disease pathogenesis (2007) (670)
- COMPASS: A complex of proteins associated with a trithorax-related SET domain protein (2001) (594)
- Histone H4 lysine-16 acetylation regulates cellular lifespan (2009) (589)
- Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span (2017) (579)
- Methylation of Histone H3 by COMPASS Requires Ubiquitination of Histone H2B by Rad6* (2002) (556)
- RNA Polymerase II Elongation Factors of Saccharomyces cerevisiae: a Targeted Proteomics Approach (2002) (537)
- The Language of Histone Crosstalk (2010) (530)
- Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. (2003) (524)
- AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. (2010) (509)
- RAD6-Mediated Transcription-Coupled H2B Ubiquitylation Directly Stimulates H3K4 Methylation in Human Cells (2009) (487)
- Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation. (2008) (484)
- Histone modification: cause or cog? (2011) (443)
- Histone Crosstalk between H2B Monoubiquitination and H3 Methylation Mediated by COMPASS (2007) (441)
- Integrator, a Multiprotein Mediator of Small Nuclear RNA Processing, Associates with the C-Terminal Repeat of RNA Polymerase II (2005) (430)
- COMPASS, a Histone H3 (Lysine 4) Methyltransferase Required for Telomeric Silencing of Gene Expression* (2002) (426)
- The Paf1 Complex Is Essential for Histone Monoubiquitination by the Rad6-Bre1 Complex, Which Signals for Histone Methylation by COMPASS and Dot1p* (2003) (407)
- Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia (2020) (391)
- Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia (2020) (391)
- Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II (2009) (367)
- Epigenetic balance of gene expression by Polycomb and COMPASS families (2016) (351)
- Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes (2006) (340)
- An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene (1996) (337)
- The super elongation complex (SEC) family in transcriptional control (2012) (325)
- Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors (2011) (323)
- The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development (2015) (321)
- The super elongation complex (SEC) and MLL in development and disease. (2011) (319)
- Molecular Regulation of H3K4 Trimethylation by Wdr82, a Component of Human Set1/COMPASS (2008) (315)
- Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. (2012) (314)
- The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers (2013) (313)
- Histone H3 lysine 4 (H3K4) methylation in development and differentiation. (2010) (309)
- Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). (2010) (303)
- Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas (2017) (294)
- Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. (2005) (285)
- Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth (2015) (282)
- Enhancer biology and enhanceropathies (2014) (258)
- Physical and Functional Association of a Trimethyl H3K4 Demethylase and Ring6a/MBLR, a Polycomb-like Protein (2007) (255)
- Born to run: control of transcription elongation by RNA polymerase II (2018) (239)
- Rtt109 Is Required for Proper H3K56 Acetylation (2006) (238)
- SET for life: biochemical activities and biological functions of SET domain-containing proteins. (2013) (233)
- The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. (2010) (227)
- Epigenetic modifications of histones in cancer (2019) (219)
- Control of elongation by RNA polymerase II. (2000) (212)
- The COMPASS Family of H3K4 Methylases in Drosophila (2011) (210)
- The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS. (2005) (199)
- Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. (2005) (198)
- A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation (2008) (198)
- Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. (2009) (196)
- A role for H3K4 monomethylation in gene repression and partitioning of chromatin readers. (2014) (192)
- Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis (2010) (191)
- Lung transplantation for patients with severe COVID-19 (2020) (180)
- Transcriptional Elongation by RNA Polymerase II and Histone Methylation* (2003) (179)
- PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II (2015) (175)
- MUF1, A Novel Elongin BC-interacting Leucine-rich Repeat Protein That Can Assemble with Cul5 and Rbx1 to Reconstitute a Ubiquitin Ligase* (2001) (172)
- Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC). (2011) (169)
- The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells (2013) (167)
- Histone H3 Lysine 36 Dimethylation (H3K36me2) Is Sufficient to Recruit the Rpd3s Histone Deacetylase Complex and to Repress Spurious Transcription* (2009) (161)
- Cse4 is part of an octameric nucleosome in budding yeast. (2009) (161)
- Chromatin signatures of cancer (2015) (158)
- The Super Elongation Complex Family of RNA Polymerase II Elongation Factors: Gene Target Specificity and Transcriptional Output (2012) (154)
- Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling (2014) (151)
- Enhancer malfunction in cancer. (2014) (150)
- Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability (2017) (146)
- Drosophila UTX Is a Histone H3 Lys27 Demethylase That Colocalizes with the Elongating Form of RNA Polymerase II (2007) (138)
- Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing (2015) (137)
- A site to remember: H3K36 methylation a mark for histone deacetylation. (2007) (135)
- Integrator regulates transcriptional initiation and pause release following activation. (2014) (131)
- Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1 (2009) (130)
- Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human (2011) (128)
- The roles of Polycomb repressive complexes in mammalian development and cancer (2021) (128)
- Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation (2020) (127)
- Enhancer Logic and Mechanics in Development and Disease. (2018) (125)
- WDR5, a complexed protein (2009) (124)
- Epigenetics of hematopoiesis and hematological malignancies (2016) (119)
- Factors regulating the transcriptional elongation activity of RNA polymerase II (1998) (117)
- Dot1 and histone H3K79 methylation in natural telomeric and HM silencing. (2011) (116)
- The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase (2007) (116)
- Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma (2017) (112)
- The H3K27me3 Demethylase dUTX Is a Suppressor of Notch- and Rb-Dependent Tumors in Drosophila (2010) (111)
- Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy (2018) (111)
- Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123. (2011) (110)
- A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL. (2000) (109)
- The RNA polymerase II elongation complex. (2003) (104)
- Parafibromin, a Component of the Human PAF Complex, Regulates Growth Factors and Is Required for Embryonic Development and Survival in Adult Mice (2008) (103)
- MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer. (2016) (103)
- ELL2, a new member of an ELL family of RNA polymerase II elongation factors. (1997) (101)
- Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide (2015) (101)
- Precancer Atlas to Drive Precision Prevention Trials. (2017) (98)
- MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. (2018) (97)
- Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory (2016) (97)
- Mitotic Transcriptional Activation: Clearance of Actively Engaged Pol II via Transcriptional Elongation Control in Mitosis. (2015) (90)
- Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications. (2017) (90)
- Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia (2017) (89)
- The RNA Pol II Elongation Factor Ell3 Marks Enhancers in ES Cells and Primes Future Gene Activation (2013) (88)
- Promoter bivalency favors an open chromatin architecture in embryonic stem cells (2018) (87)
- A COMPASS in the voyage of defining the role of trithorax/MLL‐containing complexes: Linking leukemogensis to covalent modifications of chromatin (2005) (86)
- UTX Mutations in Human Cancer. (2019) (85)
- Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation (2005) (84)
- ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. (2005) (84)
- Zic2 is an enhancer-binding factor required for embryonic stem cell specification (2015) (84)
- The little elongation complex regulates small nuclear RNA transcription. (2011) (83)
- PAF1 regulation of promoter-proximal pause release via enhancer activation (2017) (83)
- The evolving genomic landscape of urothelial carcinoma (2017) (81)
- Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1. (2012) (79)
- TET2 coactivates gene expression through demethylation of enhancers (2018) (79)
- NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release. (2020) (78)
- COMPASS and SWI/SNF complexes in development and disease (2020) (77)
- Dietary palmitic acid promotes a prometastatic memory via Schwann cells (2021) (77)
- Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling (2006) (77)
- Ctk Complex-Mediated Regulation of Histone Methylation by COMPASS (2006) (76)
- A Carcinogen-induced Mouse Model Recapitulates the Molecular Alterations of Human Muscle Invasive Bladder Cancer (2017) (75)
- Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex (2018) (75)
- Bur1/Bur2 and the Ctk Complex in Yeast: The Split Personality of Mammalian P-TEFb (2006) (74)
- Identification, Cloning, Expression, and Biochemical Characterization of the Testis-specific RNA Polymerase II Elongation Factor ELL3* (2000) (73)
- dELL is an essential RNA polymerase II elongation factor with a general role in development (2002) (73)
- Transcriptional elongation control by RNA polymerase II: a new frontier. (2004) (72)
- CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism (2019) (71)
- Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy (2018) (71)
- Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment (2007) (67)
- The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting (2019) (67)
- Histone demethylation by hydroxylation: chemistry in action. (2006) (66)
- Polycomb Repressive Complex 2-Dependent and -Independent Functions of Jarid2 in Transcriptional Regulation in Drosophila (2012) (66)
- Posttranslational modifications of histones by methylation. (2004) (66)
- Multiple Mixed Lineage Leukemia (MLL) Fusion Proteins Suppress p53-mediated Response to DNA Damage* (2005) (65)
- Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification. (2017) (64)
- Leaving a mark: the many footprints of the elongating RNA polymerase II. (2006) (64)
- The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation. (2000) (63)
- Transcriptional elongation checkpoint control in development and disease. (2013) (63)
- Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo (2001) (62)
- Regulation of H3K4 Trimethylation via Cps40 (Spp1) of COMPASS Is Monoubiquitination Independent: Implication for a Phe/Tyr Switch by the Catalytic Domain of Set1 (2009) (61)
- The JARID2-PRC2 duality. (2010) (59)
- Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells (2014) (59)
- USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia (2018) (59)
- Reprogramming of the Epigenome by MLL1 Links Early-Life Environmental Exposures to Prostate Cancer Risk. (2016) (58)
- Analysis of dynamic changes in retinoid-induced transcription and epigenetic profiles of murine Hox clusters in ES cells (2015) (57)
- Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma. (2017) (57)
- Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation (2020) (55)
- Cross-talking histones: implications for the regulation of gene expression and DNA repair. (2005) (55)
- The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. (2013) (55)
- Enhancer-associated H 3 K 4 monomethylation by Trithorax-related , the Drosophila homolog of mammalian Mll 3 / Mll 4 (2012) (54)
- Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation (2017) (54)
- Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity (2016) (53)
- Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation (2014) (52)
- Histone H3 K4 Demethylation during Activation and Attenuation of GAL1 Transcription in Saccharomyces cerevisiae (2007) (50)
- A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism (2017) (50)
- A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation (2017) (49)
- An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS. (2016) (49)
- Structure and Function of RNA Polymerase II Elongation Factor ELL (1997) (49)
- Molecular Basis of p53 Functional Inactivation by the Leukemic Protein MLL-ELL (2003) (49)
- An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells (2018) (48)
- A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis. (2018) (47)
- The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts (2020) (47)
- Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis (2018) (46)
- Mechanism and regulation of transcriptional elongation and termination by RNA polymerase II. (1997) (46)
- SnapShot: Histone Lysine Methylase Complexes (2012) (44)
- LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells (2019) (43)
- Regulation of Heat Shock Gene Expression by RNA Polymerase II Elongation Factor, Elongin A* (2005) (41)
- SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression (2017) (41)
- Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL (2008) (41)
- A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation (2015) (39)
- Cloning and Characterization of the EAP30 Subunit of the ELL Complex That Confers Derepression of Transcription by RNA Polymerase II* (1999) (39)
- Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine (1993) (38)
- Expression of human H-type alpha1,2-fucosyltransferase encoding for blood group H(O) antigen in Chinese hamster ovary cells. Evidence for preferential fucosylation and truncation of polylactosamine sequences. (1997) (38)
- In Vivo Requirement of the RNA Polymerase II Elongation Factor Elongin A for Proper Gene Expression and Development (2004) (38)
- Molecular basis for DPY-30 association to COMPASS-like and NURF complexes. (2014) (38)
- Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity (2018) (37)
- Transcription Factors TFIIF, ELL, and Elongin Negatively Regulate SII-induced Nascent Transcript Cleavage by Non-arrested RNA Polymerase II Elongation Intermediates* (2001) (37)
- Cloning and Characterization of ELL-associated Proteins EAP45 and EAP20 (2001) (37)
- Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma (2019) (37)
- Functional Analysis of the Leukemia Protein ELL: Evidence for a Role in the Regulation of Cell Growth and Survival (2001) (35)
- Detection of histone H3 K27M mutation and post-translational modifications in pediatric diffuse midline glioma via tissue immunohistochemistry informs diagnosis and clinical outcomes (2018) (35)
- The RNA polymerase II general elongation complex. (1998) (30)
- Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche (2013) (30)
- DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation (2020) (30)
- Inhibit globally, act locally: CDK7 inhibitors in cancer therapy. (2014) (29)
- Identification and Purification of the Holo-ELL Complex (1998) (29)
- A Conserved Patch near the C Terminus of Histone H4 Is Required for Genome Stability in Budding Yeast (2011) (29)
- Multiple Roles for the MLL/COMPASS Family in the Epigenetic Regulation of Gene Expression and in Cancer (2017) (29)
- SPT5 stabilization of promoter-proximal RNA polymerase II. (2021) (29)
- Coordinated regulation of cellular identity–associated H3K4me3 breadth by the COMPASS family (2020) (28)
- Global proteomic analysis of S. cerevisiae (GPS) to identify proteins required for histone modifications. (2004) (28)
- gp160 of HIV-I synthesized by persistently infected Molt-3 cells is terminally glycosylated: evidence that cleavage of gp160 occurs subsequent to oligosaccharide processing. (1991) (25)
- Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements (2016) (25)
- Epigenomic landscape and 3D genome structure in pediatric high-grade glioma (2021) (25)
- Human PC4 Is a Substrate-specific Inhibitor of RNA Polymerase II Phosphorylation* (2000) (25)
- Main group metal halide complexes with sterically hindered thioureas XIII. Crystallographic study of a unique cross-linked polymeric dichlorolead(II) complex with 1,1′-methylenebis(3-methyl-2(3H)-imidazolethione) (1992) (25)
- Histone H 3 Lysine 4 ( H 3 K 4 ) Methylation in Development and Differentiation (2013) (24)
- Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia (2021) (24)
- Drosophila SETs Its Sights on Cancer: Trr/MLL3/4 COMPASS-Like Complexes in Development and Disease (2013) (24)
- Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation. (2018) (24)
- β-Catenin/Tcf7l2–dependent transcriptional regulation of GLUT1 gene expression by Zic family proteins in colon cancer (2019) (23)
- Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia (2018) (19)
- Packing for the germy: the role of histone H4 Ser1 phosphorylation in chromatin compaction and germ cell development. (2006) (19)
- Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression (2021) (19)
- The curious case of bivalent marks. (2009) (18)
- The Elongin B Ubiquitin Homology Domain (1999) (17)
- Decoding the Protein Composition of Whole Nucleosomes with Nuc-MS (2020) (17)
- Transcription syndromes and the role of RNA polymerase II general transcription factors in human disease. (1996) (16)
- Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary Fibrosis (2018) (15)
- Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells (2020) (15)
- Histone H 2 BK 123 monoubiquitination is the critical determinant for H 3 K 4 and H 3 K 79 trimethylation by COMPASS and Dot 1 (2009) (14)
- Targeting DNA Methylation Depletes Uterine Leiomyoma Stem Cell–enriched Population by Stimulating Their Differentiation (2020) (14)
- Lung transplantation for pulmonary fibrosis secondary to severe COVID-19 (2020) (14)
- Cloning and Characterization of ELL-associated Proteins EAP45 and EAP20 A ROLE FOR YEAST EAP-LIKE PROTEINS IN REGULATION OF GENE EXPRESSION BY GLUCOSE* (2001) (14)
- Mutational Analysis of an RNA Polymerase II Elongation Factor in Drosophila melanogaster (2005) (13)
- Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis (2018) (12)
- Integrator enforces the fidelity of transcriptional termination at protein-coding genes (2021) (12)
- Structural basis for H3K4 trimethylation by yeast Set1/COMPASS. (2010) (12)
- The A, B, Gs of silencing. (2007) (11)
- Transcriptional blackjack with p21. (2006) (11)
- Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte recruitment (2021) (10)
- A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress (2020) (10)
- (Poly)Combing the Pediatric Cancer Genome for Answers (2013) (10)
- Inhibition of Transcription by the Trimeric Cyclin-dependent Kinase 7 Complex* (1999) (9)
- Histone Cross-Talk in Stem Cells (2009) (9)
- Effects of H3.3G34V mutation on genomic H3K36 and H3K27 methylation patterns in isogenic pediatric glioma cells (2020) (8)
- A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS (2019) (8)
- A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer (2021) (8)
- A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4/COMPASS and is sufficient to rescue loss of viability in null animals (2020) (8)
- UBR7 acts as a histone chaperone for post‐nucleosomal histone H3 (2021) (7)
- LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription (2018) (7)
- Deregulation of c-Myc by leukemogenic MLL fusion proteins (2000) (7)
- Detection of histone H 3 K 27 M mutation and post-translational modifications in pediatric diffuse midline glioma via tissue immunohistochemistry informs diagnosis and clinical outcomes (2019) (6)
- Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma. (2021) (6)
- SPT6 functions in transcriptional pause/release via PAF1C recruitment. (2022) (6)
- Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumor. (2022) (5)
- NCI-CONNECT: Comprehensive Oncology Network Evaluating Rare CNS Tumors-Histone Mutated Midline Glioma Workshop Proceedings. (2020) (5)
- Born to run: control of transcription elongation by RNA polymerase II (2018) (5)
- A ChIP-exo screen of 887 Protein Capture Reagents Program transcription factor antibodies in human cells (2021) (4)
- A pilot study of tazemetostat and MK-3475 (pembrolizumab) in advanced urothelial carcinoma (ETCTN 10183). (2020) (4)
- Guided by COMPASS on a journey through chromosome segregation (2005) (4)
- PDTM-34. RADIOSENSITIZATION BY BRD4 INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA (2019) (3)
- The role of histone modifications in leukemogenesis (2020) (3)
- Purification and characterization of N-acetylglucosamine-6-sulfate sulfatase from bovine kidney: evidence for the presence of a novel endosulfatase activity. (1994) (3)
- It's a DoG-eat-DoG world-altered transcriptional mechanisms drive downstream-of-gene (DoG) transcript production. (2022) (3)
- Epigenetic Reprogramming of Host and Viral Genes by Human Cytomegalovirus Infection in Kasumi-3 Myeloid Progenitor Cells at Early Times Postinfection (2021) (3)
- Correction: Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells (2015) (3)
- Expression of Human H-type α1,2-Fucosyltransferase Encoding for Blood Group H(O) Antigen in Chinese Hamster Ovary Cells (1997) (3)
- Abstract LB-064: Characterization of the tumor suppressor function of the lysine-specific methyltransferase KMT2D in follicular lymphoma (2015) (3)
- The SEC family of RNA Polymerase II elongation factors: gene (2012) (3)
- Sulphate release from keratan sulphate and heparan sulphate by bovine N-acetylglucosamine-6-sulphate sulphatase. (1995) (3)
- A phosphorylation switch on RbBP 5 regulates histone H 3 Lys 4 methylation (2015) (3)
- Immune activation is essential for the antitumor activity of EZH2 inhibition in urothelial carcinoma (2022) (2)
- Preparation and assay of RNA polymerase II elongation factors elongin and ELL. (2003) (2)
- Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas (2017) (2)
- A ChIP-exo screen of 887 PCRP transcription factor antibodies in human cells (2020) (2)
- ATRT-02. THERAPEUTIC TARGETING OF EZH2 AND BET BRD4 IN AT/RT (2019) (2)
- PDTM-28. TARGETED INHIBITION OF EZH2 AND BET BROMODOMAIN PROTEINS FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMAS (2017) (2)
- PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing. (2022) (2)
- Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma (2017) (2)
- TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas (2019) (2)
- COVID-19: Rescue by transcriptional inhibition (2020) (2)
- Epigenetic ConFUSION: SS18-SSX Fusion Rewires BAF Complex to Activate Bivalent Genes in Synovial Sarcoma. (2018) (2)
- Multiple MLL fusion proteins suppress p53-mediated response to DNA damage (2004) (2)
- Guided by COMPASS on a Journey Through Chromatin Modifications, Regulation of Gene Expression and the Pathogenesis of Leukemia (2006) (2)
- Medicine in the time of corona: Fundamental molecular research is “essential” (2020) (2)
- Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer (2022) (1)
- Multiple Roles for the MLL/COMPASS Family in Cancer (2016) (1)
- EPEN-20. EZHIP/CATACOMB COOPERATES WITH PDGF-A AND p53 LOSS TO GENERATE A GENETICALLY ENGINEERED MOUSE MODEL FOR POSTERIOR FOSSA A EPENDYMOMA (2020) (1)
- A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A/COMPASS in mouse embryonic stem cells (2022) (1)
- Enhancers in cancer: Genetic and epigenetic deregulation (2018) (1)
- Screening of PCRP transcription factor antibodies in biochemical assays (2020) (1)
- Human TFIIH Kinase CDK7 Regulates Transcription-Associated Epigenetic Modifications (2018) (1)
- Chromosomes and gene expression mechanisms: peeling away the many layers of transcriptional control. (2011) (1)
- Treating Alzheimer's from the start (2016) (1)
- DIPG-03. THERAPEUTIC TARGETING OF TRANSCRIPTIONAL ELONGATION IN DIFFUSE INTRINSIC PONTINE GLIOMA (2020) (1)
- A Histone Modifier’s Ill-Gotten Copy Gains (2013) (1)
- Author Correction: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity (2019) (1)
- Erratum: COMPASS: A complex of proteins associated with a trithorax-related SET domain protein (Proceedings of the National Academy of Sciences of the United States of America (November 6, 2001) 98:23 (112902-12907)) (2001) (1)
- Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C (2023) (1)
- Global proteomic analysis of Saccharomyces cerevisiae identifies molecular pathways of histone modifications. (2009) (1)
- Cloning and Characterization of ELL-associated Proteins EAP 45 and EAP 20 (2001) (1)
- Editorial expression of concern (2020) (1)
- Author response: Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory (2016) (1)
- Lessons learned from yeast about human leukemia (2010) (0)
- abstract in Blood 2000 (2014) (0)
- 3D Genome Structure and Epigenetic Transcription Regulation in Pediatric High-Grade Glioma (2022) (0)
- PDTM-42. TARGETED INHIBITION OF BET BROMODOMAIN AND JMJD3 PROTEINS FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (2018) (0)
- Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy (2018) (0)
- PDTM-39. HISTONE H3 MUTATION EFFECTS ON CHROMATIN STRUCTURE AND REGULATION OF GENE TRANSCRIPTION IN PEDIATRIC GLIOMA (2018) (0)
- Link between histone deubiquitination and protection of telomeres (2005) (0)
- PDTB-10. INHIBITION OF RADIATION-INDUCED DNA DAMAGE REPAIR MEDIATED CHROMATIN MODIFICATION BY HISTONE H3 DEMETHYLASE INHIBITOR IN PEDIATRIC BRAINSTEM GLIOMA (2016) (0)
- DIPG-28. RADIATION DNA DAMAGE REPAIR INHIBITION BY GSK-J4 INDUCED CHROMATIN COMPACTION IN DIPG. (2017) (0)
- CRISPRing Candida for health's sake (2015) (0)
- UBR7 Promotes Accumulation of NASP‐Bound Pre‐Existing Histone H3 (2021) (0)
- Effects of H3.3G34V mutation on genomic H3K36 and H3K27 methylation patterns in isogenic pediatric glioma cells (2020) (0)
- This Week in Science (2017) (0)
- PDTM-05. RADIATION DNA DAMAGE REPAIR INHIBITION BY GSK-J4 INDUCED CHROMATIN COMPACTION IN DIPG (2018) (0)
- DIPG-63. RADIATION DNA DAMAGE REPAIR INHIBITION BY GSK-J4 INDUCED CHROMATIN COMPACTION IN DIPG (2018) (0)
- Building on a strong foundation (2021) (0)
- HGG-01. 3D GENOME STRUCTURE IMPACTS GENE EXPRESSION IN PEDIATRIC HIGH-GRADE GLIOMA (2021) (0)
- This Week in Science (2015) (0)
- PDTB-13. DETECTION OF HISTONE H3 MUTATIONS IN PEDIATRIC GLIOMA VIA TUMOR DNA DERIVED FROM CEREBROSPINAL FLUID (2016) (0)
- EXTH-82. THERAPEUTIC TARGETING OF EZH2 AND BET BRD4 IN PEDIATRIC RHABDOID TUMORS (2022) (0)
- PDTM-02. NEXT-GENERATION SEQUENCING OF DIFFUSE INTRINSIC PONTINE GLIOMA CELLS REVEALS ALTERED EPIGENETIC REGULATION AND DISTINCT TUMOR SUBGROUPS (2017) (0)
- DIPG-24. TARGETED INHIBITION OF JMJD3 AND BET BROMODOMAIN PROTEINS FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMAS (2018) (0)
- The Jumonji-C Histone Lysine Demethylase KDM3B Senses Cellular Iron to Regulate Anabolism Through mTORC1 (2021) (0)
- Selective inhibition of metastasis in vivo, partly through disruption of nucleoli (2019) (0)
- This Week in Science (2016) (0)
- Mapping Alzheimer's disease (2016) (0)
- Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in OriLyt (2023) (0)
- Editorial expression of concern (2021) (0)
- This Week in Science (2018) (0)
- Abstract B46: CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb Repressive complex 2 via a H3K27M-like mechanism (2020) (0)
- The α-satellite arrays of human centromeres (2015) (0)
- Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation (2020) (0)
- A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia (2018) (0)
- HGG-02. Epigenetic transcription regulation and 3D genome structure in pediatric high-grade glioma (2022) (0)
- Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity (2018) (0)
- Editorial Retraction (2015) (0)
- COMPASS and SWI/SNF complexes in development and disease (2020) (0)
- Advances in Ultramicroscope Technology (2019) (0)
- The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity–independent genomic targeting (2019) (0)
- 195 3D Genome Structure and Epigenetic Transcription Regulation in Pediatric High-Grade Glioma (2022) (0)
- Terri Grodzicker: Editor, leader, and friend (2023) (0)
- Context Dependent Histone Modification during Transcription Elongation (2013) (0)
- PDTB-14. INVESTIGATING HISTONE H3 POST-TRANSLATIONAL MODIFICATIONS USING PARAFFIN-EMBEDDED PEDIATRIC GLIOMA TISSUE SAMPLES (2016) (0)
- Transcription elongation control by RNA polymerase II (2007) (0)
- Mdm30p, an F‐box protein, stimulates export of mRNA in vivo. (2007) (0)
- DDIS-13. UNDERSTANDING GLIOBLASTOMA SUSCEPTIBILITY TO TOP2-TARGETING DRUGS FOR PERSONALIZED THERAPY (2018) (0)
- Basic principles of cancer metabolism (2016) (0)
- Author Correction: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity (2019) (0)
- The dire need for federal support of molecular research, then and now. (2022) (0)
- Abstract IA5: Chromosomal translocations and transcriptional elongation control in epigenetics and cancer (2013) (0)
- DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, CARDIOVASCULAR, AND CANCER CENTER 2013-2014 SEMINAR SCHEDULE* Please obtain prior approval when inviting a guest speaker from Dr. Di Cera. DATE SPEAKER HOST (2014) (0)
- On Healthy Scientific Debates. (2022) (0)
- Impactful science as the guiding principle (2018) (0)
- This Week in Science (2015) (0)
- Editorial overview: Cancer genomics: Darwin meets Waddington: the interplay between cancer genomes and epigenomes. (2016) (0)
- DIPG-14. INTEGRATED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) NEXT-GENERATION SEQUENCING REVEALS EPIGENETIC DYSREGULATION OF GENE EXPRESSION AND BROMODOMAIN INHIBITION AS A NOVEL THERAPEUTIC TARGET (2018) (0)
- This Week in Science (2016) (0)
- Abstract IA18: Functional characterization of the tumor suppressor lysine-specific methyltransferase KMT2D in lymphoma (2016) (0)
- Crystal structure of Ash2L SPRY domain in complex with phosphorylated RbBP5 (2015) (0)
- DIPG-24. EPIGENETIC ANALYSIS OF FORMALIN-FIXED PARAFFIN-EMBEDDED PEDIATRIC GLIOMA TISSUE (2017) (0)
- Myoediting for Duchenne muscular dystrophy (2018) (0)
- Promoter bivalency favors an open chromatin architecture in embryonic stem cells (2018) (0)
- The role of histone modifications in leukemogenesis (2020) (0)
- Correction: Detection of histone H3 K27M mutation and post-translational modifications in pediatric diffuse midline glioma via tissue immunohistochemistry informs diagnosis and clinical outcomes (2019) (0)
- Harnessing the power of heterologous biosynthesis (2015) (0)
- Parafibromin, a Component of the Human PAF Complex, Regulates Growth Factors and Is Required for Embryonic Development and Survival in Adult Mice (cid:1) † (2008) (0)
- Correction (1981) (0)
- Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription (2023) (0)
- Part 4: Targeting cancer pathways: The epigenetics question (2015) (0)
- Expanding the breadth and depth of Science Advances (2021) (0)
- Polycomb fusion proteins in endometrial stromal sarcomas (2018) (0)
- PDTM-31. INVESTIGATING THE EFFECT OF H3G34V MUTATION ON DISTINCT GENOMIC H3K36 METHYLATION PATTERNS IN PEDIATRIC GLIOMA (2019) (0)
- HGG-26. H3G34V MUTATION AFFECTS GENOMIC H3K36 METHYLATION IN PEDIATRIC GLIOMA (2020) (0)
- Epigenetic modifications of histones in cancer (2019) (0)
- HGG-10. HISTONE H3G34V MUTATION IS SUFFICIENT TO DRIVE DISTINCT GENOMIC H3K36 METHYLATION PATTERNS IN PEDIATRIC GLIOMA (2019) (0)
- Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer (2022) (0)
- Cas9 endonuclease and off-target activity (2017) (0)
- A CHAF 1 B-Dependent Mo lecular Switch in Hematopoiesis and Leukemia Pathogenesis Graphical (2018) (0)
- Chromatin and transcriptional regulation (2006) (0)
- Crystal structure of Ash2L SPRY domain in complex with RbBP5 (2015) (0)
- CARM1-mediated methylation of ASXL2 impairs tumor-suppressive function of MLL3/COMPASS (2022) (0)
- Amalgamated regulators of gene expression (2015) (0)
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