Allan Bradley
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Engineering Computer Science
Allan Bradley's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
- Bachelors Computer Engineering University of California, Berkeley
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(Suggest an Edit or Addition)Allan Bradley's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Identification of mammalian microRNA host genes and transcription units. (2004) (2078)
- Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice (1991) (2055)
- Requirement of bic/microRNA-155 for Normal Immune Function (2007) (1945)
- Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. (2000) (1712)
- Increased bone formation in osteocalcin-deficient mice (1996) (1650)
- Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines (1984) (1554)
- The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain (1990) (1528)
- A conditional knockout resource for the genome-wide study of mouse gene function (2011) (1503)
- p53 mutant mice that display early ageing-associated phenotypes (2002) (1423)
- Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis (1992) (1383)
- Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 (1995) (1321)
- Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene (1993) (1319)
- p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells (1995) (1155)
- Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements (2018) (1120)
- Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 (1997) (1091)
- BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. (1995) (1047)
- Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. (1996) (1015)
- Impaired energy homeostasis in C/EBP alpha knockout mice (1995) (993)
- A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. (1999) (970)
- Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice (2001) (932)
- Requirement for Wnt3 in vertebrate axis formation (1999) (931)
- Nonredundant Roles of the mPer1 and mPer2 Genes in the Mammalian Circadian Clock (2001) (857)
- α-lnhibin is a tumour-suppressor gene with gonadal specificity in mice (1992) (842)
- High-throughput discovery of novel developmental phenotypes (2016) (824)
- Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over (1996) (821)
- microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. (2007) (816)
- Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector (1986) (754)
- The mPer2 gene encodes a functional component of the mammalian circadian clock (1999) (706)
- Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells (2011) (661)
- Multiple defects and perinatal death in mice deficient in follistatin (1995) (634)
- Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon (2009) (620)
- Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. (1993) (615)
- Functional analysis of activins during mammalian development (1995) (607)
- Different phenotypes for mice deficient in either activins or activin receptor type II (1995) (604)
- The midbrain-hindbrain phenotype of Wnt-1− Wnt-1− mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum (1992) (593)
- Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice (1993) (590)
- The Knockout Mouse Project (2004) (574)
- A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. (1993) (559)
- A hyperactive piggyBac transposase for mammalian applications (2011) (538)
- The Molecular Clock Mediates Leptin-Regulated Bone Formation (2005) (532)
- Disruption of muscle architecture and myocardial degeneration in mice lacking desmin (1996) (518)
- In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. (1993) (515)
- Chromosome engineering in mice (1995) (494)
- A potential animal model for Lesch–Nyhan syndrome through introduction of HPRT mutations into mice (1987) (492)
- Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors (1993) (491)
- Retention of wild‐type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation (1998) (477)
- Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. (1999) (424)
- Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes (2013) (424)
- Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1 (1996) (424)
- Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency‐Associated Genes (2010) (423)
- Abnormal Behavior in a Chromosome- Engineered Mouse Model for Human 15q11-13 Duplication Seen in Autism (2009) (415)
- Congenital heart disease in mice deficient for the DiGeorge syndrome region (1999) (409)
- An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease (2010) (388)
- Cancer predisposition caused by elevated mitotic recombination in Bloom mice (2000) (386)
- Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. (1998) (384)
- Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice. (1994) (379)
- Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair (1998) (376)
- Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. (2003) (363)
- Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments (1993) (362)
- Chromosomal transposition of PiggyBac in mouse embryonic stem cells (2008) (353)
- Agouti C57BL/6N embryonic stem cells for mouse genetic resources (2009) (344)
- Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. (1992) (344)
- The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages. (1995) (326)
- Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. (1995) (313)
- Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. (1994) (310)
- Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. (1995) (304)
- Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice (1995) (304)
- The tumore suppressor p53 (1993) (303)
- Genetic background alters the spectrum of tumors that develop in p53‐deficient mice (1993) (300)
- Generation of an inducible and optimized piggyBac transposon system† (2007) (280)
- Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. (1994) (280)
- Transposon-mediated genome manipulation in vertebrates (2009) (279)
- The mammalian gene function resource: the international knockout mouse consortium (2012) (277)
- Effects of genetic background on tumorigenesis in p53‐deficient mice (1995) (273)
- The length of homology required for gene targeting in embryonic stem cells (1991) (273)
- Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes (2018) (272)
- Gene targeting yields a CD18-mutant mouse for study of inflammation. (1993) (259)
- Genetic Background Drives Transcriptional Variation in Human Induced Pluripotent Stem Cells (2014) (252)
- High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC (1995) (252)
- Engineering chromosomal rearrangements in mice (2001) (249)
- Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells. (1998) (243)
- Requirement of the paraxis gene for somite formation and musculoskeletal patterning (1996) (243)
- A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice (1995) (242)
- Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1 (2011) (240)
- Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells (1991) (239)
- Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed. (1995) (236)
- Genomic DNA microextraction: a method to screen numerous samples. (1992) (228)
- Evidence that Meiotic Sex Chromosome Inactivation Is Essential for Male Fertility (2010) (225)
- PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice (2010) (213)
- Functional genetic analysis of mouse chromosome 11 (2003) (209)
- Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays (2002) (205)
- The tumor suppressor p53. (1993) (202)
- Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice (2011) (201)
- Engineering Mouse Chromosomes with Cre-loxP: Range, Efficiency, and Somatic Applications (2000) (196)
- Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin. (1995) (194)
- Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model. (2002) (194)
- Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene. (2002) (193)
- Tools for targeted manipulation of the mouse genome. (2002) (190)
- Disease Model Discovery from 3,328 Gene Knockouts by The International Mouse Phenotyping Consortium (2017) (190)
- A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. (2010) (190)
- Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes. (1999) (188)
- A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer (2014) (188)
- Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells (1991) (185)
- Gene targeting in embryonic stem cells. (1993) (184)
- Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. (1999) (181)
- Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability (2010) (175)
- A Genetic Progression Model of BrafV600E-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention (2013) (172)
- Mice Deficient for the Wild-Type p53-Induced Phosphatase Gene (Wip1) Exhibit Defects in Reproductive Organs, Immune Function, and Cell Cycle Control (2002) (170)
- CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice (2015) (165)
- Targeted Deletion of MicroRNA-22 Promotes Stress-Induced Cardiac Dilation and Contractile Dysfunction (2012) (163)
- Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies (2016) (162)
- Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. (1995) (159)
- Erratum: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements (2018) (159)
- Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells (2004) (153)
- Activin signaling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient mice. (1996) (151)
- Mobilization of giant piggyBac transposons in the mouse genome (2011) (148)
- Targeting frequency for deletion vectors in embryonic stem cells (1994) (141)
- Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project (2012) (140)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage (2006) (138)
- Normal Germ Line Establishment in Mice Carrying a Deletion of the Ifitm/Fragilis Gene Family Cluster (2008) (138)
- Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development. (2006) (138)
- Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery (2014) (136)
- Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice (2016) (136)
- Mutagenic Insertion and Chromosome Engineering Resource (MICER) (2004) (135)
- Loss of p53 function leads to metastasis in ras+myc-initiated mouse prostate cancer. (1995) (135)
- Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei (2007) (134)
- Histone deacetylase (HDAC) 1 and 2 are essential for normal T cell development and genomic stability in mice (2013) (134)
- Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice (2016) (133)
- Chromosomal mobilization and reintegration of Sleeping Beauty and PiggyBac transposons (2009) (132)
- Engineering a mouse balancer chromosome (1999) (132)
- A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice. (1999) (131)
- A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus. (1993) (126)
- A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector construction. (2005) (119)
- Cytoskeletal control of myogenesis: a desmin null mutation blocks the myogenic pathway during embryonic stem cell differentiation. (1995) (116)
- p 63 is a p 53 homologue required for limband epidermalmorphogenesis (115)
- Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) Contiguous Gene Syndromes by Chromosome Engineering in Mice: Phenotypic Consequences of Gene Dosage Imbalance (2003) (115)
- The RASSF1A Isoform of RASSF1 Promotes Microtubule Stability and Suppresses Tumorigenesis (2005) (113)
- ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing (2013) (112)
- COP9 Signalosome Subunit 3 Is Essential for Maintenance of Cell Proliferation in the Mouse Embryonic Epiblast (2003) (105)
- p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. (2006) (105)
- Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis. (2006) (104)
- A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction (2017) (104)
- ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks (2018) (104)
- IgA class switch in I alpha exon-deficient mice. Role of germline transcription in class switch recombination. (1996) (103)
- C13orf31 (FAMIN) is a central regulator of immunometabolic function (2016) (101)
- Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells (1991) (99)
- Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. (1997) (99)
- Loss of TSLC1 Causes Male Infertility Due to a Defect at the Spermatid Stage of Spermatogenesis (2006) (99)
- Modifying the Mouse: Design and Desire (1992) (99)
- Erratum: Corrigendum: The European dimension for the mouse genome mutagenesis program (2004) (95)
- A resource of vectors and ES cells for targeted deletion of microRNAs in mice (2011) (95)
- Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. (2003) (94)
- Inter-homologue repair in fertilized human eggs? (2017) (92)
- Using targeted large deletions and high-efficiency N-ethyl-N-nitrosourea mutagenesis for functional analyses of the mammalian genome. (1997) (92)
- An anchored framework BAC map of mouse chromosome 11 assembled using multiplex oligonucleotide hybridization. (1998) (91)
- Recycling selectable markers in mouse embryonic stem cells (1996) (90)
- A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization. (2003) (90)
- The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. (1996) (89)
- From mouse to man: generating megabase chromosome rearrangements. (2001) (89)
- Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy (2004) (87)
- METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation. (2021) (87)
- p53 deficiency does not affect the accumulation of point mutations in a transgene target. (1995) (85)
- Synergistic effects of inhibins and müllerian-inhibiting substance on testicular tumorigenesis. (1995) (84)
- Host sanctions and the legume – rhizobium mutualism (2014) (82)
- Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. (1998) (81)
- Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells (2016) (80)
- A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice (2013) (80)
- Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro. (1996) (78)
- A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer (2015) (78)
- Murine Brca2: sequence, map position, and expression pattern. (1997) (78)
- Urocortin-Deficient Mice Display Normal Stress-Induced Anxiety Behavior and Autonomic Control but an Impaired Acoustic Startle Response (2002) (77)
- Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factor. (1994) (76)
- The piggyBac Transposon Displays Local and Distant Reintegration Preferences and Can Cause Mutations at Noncanonical Integration Sites (2013) (76)
- Extensive genomic copy number variation in embryonic stem cells (2008) (76)
- Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress (2014) (75)
- Mosaic Complementation Demonstrates a Regulatory Role for Myosin VIIa in Actin Dynamics of Stereocilia (2007) (74)
- Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion (2013) (73)
- A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells. (2009) (72)
- A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis (2007) (72)
- A new positive/negative selectable marker, puΔtk, for use in embryonic stem cells (2000) (71)
- Chromosome engineering in zygotes with CRISPR/Cas9 (2016) (70)
- Olfactory bulb hypoplasia in Prokr2 null mice stems from defective neuronal progenitor migration and differentiation (2007) (69)
- A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer (2014) (69)
- A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations. (2000) (67)
- Complex haplotypes, copy number polymorphisms and coding variation in two recently divergent mouse strains (2005) (67)
- Embryonic stem cells: proliferation and differentiation. (1990) (63)
- The role and fate of DNA ends for homologous recombination in embryonic stem cells (1992) (63)
- Gene targeting vectors for mammalian cells. (1993) (62)
- A Practical and Efficient Cellular Substrate for the Generation of Induced Pluripotent Stem Cells from Adults: Blood‐Derived Endothelial Progenitor Cells (2012) (60)
- Murine Brca1: sequence and significance for human missense mutations. (1995) (58)
- Nested chromosomal deletions induced with retroviral vectors in mice (2000) (58)
- Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia. (2017) (58)
- Off‐target assessment of CRISPR‐Cas9 guiding RNAs in human iPS and mouse ES cells (2015) (54)
- Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior. (2006) (54)
- Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice (2001) (54)
- A targeted X‐linked CMV‐Cre line (2002) (54)
- Genetic Analysis of Mouse Embryonic Stem Cells Bearing Msh3 and Msh2 Single and Compound Mutations (2000) (54)
- A new positive/negative selectable marker, puDeltatk, for use in embryonic stem cells. (2000) (53)
- A clone-array pooled shotgun strategy for sequencing large genomes. (2001) (53)
- The Y-Encoded Gene Zfy2 Acts to Remove Cells with Unpaired Chromosomes at the First Meiotic Metaphase in Male Mice (2011) (52)
- Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells (2013) (52)
- Increased Insulin Action in SKIP Heterozygous Knockout Mice (2008) (52)
- Severe phenotype in mice with termination mutation in exon 2 of cystic fibrosis gene (1995) (52)
- Gi2α protein deficiency: A model for inflammatory bowel disease (1995) (50)
- Null and conditional semaphorin 3B alleles using a flexible puroΔtk loxP/FRT vector (2005) (50)
- Conditional inactivation of p63 by Cre‐mediated excision (2002) (50)
- Generation of a mouse model for citrullinemia by targeted disruption of the argininosuccinate synthetase gene (1994) (49)
- Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma (2017) (48)
- MiR-210 Is Induced by Oct-2, Regulates B Cells, and Inhibits Autoantibody Production (2013) (48)
- SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 (2018) (48)
- A resource of targeted mutant mouse lines for 5,061 genes (2019) (48)
- Discovery of Candidate Disease Genes in ENU–Induced Mouse Mutants by Large-Scale Sequencing, Including a Splice-Site Mutation in Nucleoredoxin (2009) (47)
- Fidelity of targeted recombination in human fibroblasts and murine embryonic stem cells. (1991) (46)
- Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25 (2017) (46)
- Tbx1 haploinsufficiency identified by functional scanning of the DiGeorge syndrome region is the cause of aortic arch defects in mice. (2001) (46)
- Experimental approaches to mammalian embryonic development: Production of permanent cell lines from early embryos and their use in studying developmental problems (1987) (45)
- Efficiency of insertion versus replacement vector targeting varies at different chromosomal loci (1994) (44)
- Mouse chromosome engineering for modeling human disease. (2006) (44)
- Reduced penetrance of craniofacial anomalies as a function of deletion size and genetic background in a chromosome engineered partial mouse model for Smith-Magenis syndrome. (2004) (44)
- Embryo-derived stem cells: a tool for elucidating the developmental genetics of the mouse. (1986) (44)
- Overexpression of Mdm 2 in mice reveals a p 53-independent role for Mdm 2 in tumorigenesis (1998) (42)
- Ectodomains of the LDL Receptor-Related Proteins LRP1b and LRP4 Have Anchorage Independent Functions In Vivo (2010) (42)
- Revealing hidden complexities of genomic rearrangements generated with Cas9 (2017) (40)
- Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes. (2005) (40)
- Gene targeting in mouse embryonic stem cells with an adenoviral vector (1995) (39)
- Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice (2017) (39)
- Gi2 alpha protein deficiency: a model of inflammatory bowel disease. (1995) (38)
- Thirteen years of manipulating the mouse genome: a personal history. (1998) (38)
- Induced mitotic recombination of p53 in vivo (2007) (38)
- A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes (2017) (37)
- High-density P300 enhancers control cell state transitions (2015) (37)
- A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening (2011) (36)
- Cloning of the human activin receptor cDNA reveals high evolutionary conservation. (1992) (36)
- Tissue-specific expression of the human type II collagen gene in mice. (1987) (36)
- Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming (2019) (35)
- Loss of Rassf1a cooperates with ApcMin to accelerate intestinal tumourigenesis (2008) (34)
- DNA mismatch repair deficient mice in cancer research. (1996) (33)
- Structure of the mouse activin receptor type II gene. (1992) (33)
- Mining the mouse genome (2002) (33)
- A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection (2019) (33)
- Novel lethal mouse mutants produced in balancer chromosome screens. (2006) (33)
- The Wnt family of cell signalling molecules in postimplantation development of the mouse. (1992) (33)
- PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice (2019) (32)
- Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential (2016) (32)
- Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries (2017) (32)
- FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle (2020) (30)
- Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p (2003) (30)
- Introducing defined chromosomal rearrangements into the mouse genome. (2001) (30)
- Detailed molecular characterisation of acute myeloid leukaemia with a normal karyotype using targeted DNA capture (2013) (30)
- A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer (2015) (30)
- The ability of EK cells to form chimeras after selection of clones in G418 and some observations on the integration of retroviral vector proviral DNA into EK cells. (1985) (26)
- Transformation of embryonic stem cells with the human type-II collagen gene and its expression in chimeric mice. (1985) (26)
- Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice (2010) (25)
- Genetic manipulation of the mouse via gene targeting in embryonic stem cells. (1992) (25)
- Visual Genotyping of a Coat Color Tagged p53 Mutant Mouse Line (2002) (25)
- Cas9-induced large deletions and small indels are controlled in a convergent fashion (2020) (25)
- Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein (2020) (24)
- miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts (2021) (24)
- Genomic organization of the mouse double minute 2 gene. (1996) (24)
- The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model. (1996) (23)
- Identification of Genes Important for Cutaneous Function Revealed by a Large Scale Reverse Genetic Screen in the Mouse (2014) (23)
- Investigation of coelectroporation as a method for introducing small mutations into embryonic stem cells (1992) (22)
- Mutation of N-myc in mice: what does the phenotype tell us? (1993) (21)
- Isolation of homozygous mutant mouse embryonic stem cells using a dual selection system (2011) (21)
- Genome-wide forward genetic screens in mouse ES cells. (2010) (21)
- Identification and analysis of tumor suppressor genes using transgenic mouse models. (1994) (20)
- A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines (2009) (20)
- A recessive genetic screen for host factors required for retroviral infection in a library of insertionally mutated Blm-deficient embryonic stem cells (2007) (19)
- Two new mouse chromosome 11 balancers. (2004) (19)
- TranscriptSNPView: a genome-wide catalog of mouse coding variation (2006) (19)
- A Deficiency in the Region Homologous to Human 17q21.33–q23.2 Causes Heart Defects in Mice (2006) (18)
- A DNA transposon-based approach to validate oncogenic mutations in the mouse (2008) (18)
- Target practice in transgenics (1996) (17)
- Inducible Gene Trapping with Drug-Selectable Markers and Cre/loxP To Identify Developmentally Regulated Genes (2004) (17)
- Bigenic Cre/loxP, puΔtk conditional genetic ablation (2004) (17)
- Site-directed mutagenesis in the mouse. (1993) (17)
- Neuronal differentiation of NTE-deficient embryonic stem cells. (2005) (17)
- An SSLP marker–anchored BAC framework map of the mouse genome (2001) (17)
- Genetic screens using the piggyBac transposon (2011) (17)
- Advances in the use of embryonic stem cell technology. (1994) (16)
- Transgenic mouse models for tumour‐suppressor genes (1995) (15)
- Influence of injected pluripotential (EK) cells on haploid and diploid parthenogenetic development. (1984) (15)
- Analysis of Pax6 Contiguous Gene Deletions in the Mouse, Mus musculus, Identifies Regions Distinct from Pax6 Responsible for Extreme Small-Eye and Belly-Spotting Phenotypes (2009) (15)
- High-throughput discovery of genetic determinants of circadian misalignment (2020) (15)
- Comprehensive annotation and evolutionary insights into the canine (Canis lupus familiaris) antigen receptor loci (2017) (14)
- PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas (2020) (14)
- Gene-targeting and the p53 tumor-suppressor gene. (1994) (14)
- CRISPR and transposon in vivo screens for cancer drivers and therapeutic targets (2020) (13)
- Gene conversion during vector insertion in embryonic stem cells. (1995) (13)
- Allelic phasing of a mouse chromosome 11 deficiency influences p53 tumorigenicity (2003) (13)
- Functional Characterization of BRCA1 and BRCA2: Clues from Their Interacting Proteins (1998) (12)
- Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage (2021) (12)
- NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia. (2019) (11)
- Disruption of the Gi2α locus in embryonic stem cells and mice: a modified hit and run strategy with detection by a PCR dependent on gap repair (1993) (11)
- Chromosome engineering in ES cells. (2009) (11)
- BRCTx Is a Novel, Highly Conserved RAD18-Interacting Protein (2005) (11)
- Stella-Cre Mice are Highly Efficient Cre Deleters (2011) (10)
- Modifying the mammalian genome by gene targeting (1992) (10)
- Genetics: Targeting sheep (2000) (9)
- Bigenic Cre/loxP, puDeltatk conditional genetic ablation. (2004) (9)
- Induced mitotic recombination: a switch in time (2002) (9)
- Irradiated Blm-deficient mice are a highly tumor prone model for analysis of a broad spectrum of hematologic malignancies. (2010) (9)
- Cancer: Stuck at first base (2002) (9)
- Role of transgenic mice in identification and characterization of tumour suppressor genes. (1995) (8)
- Elucidating T Cell Activation-Dependent Mechanisms for Bifurcation of Regulatory and Effector T Cell Differentiation by Multidimensional and Single-Cell Analysis (2018) (8)
- The mouse genome sequence: status and prospects. (2001) (8)
- Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary Cancer (2021) (8)
- Disentangling PTEN-cooperating tumor suppressor gene networks in cancer (2017) (7)
- Histone deacetylase (HDAC) 1 and 2 are essential for normal T cell development and genomic stability in mice (2013) (7)
- The Ptentative nature of mouse knockouts (1998) (7)
- Modifying the mammalian genome by gene targeting. (1991) (7)
- [29] Targeted Inactivation of the G12α gene with replacement and insertion vectors: Analysis in a 96-well plate format (1994) (7)
- Targeting of the Gi2α Gene in es cells with Replacement and Insertion Vectors (1993) (6)
- …and secreted tumour suppressors (1996) (6)
- Corrigendum: High-throughput discovery of novel developmental phenotypes (2017) (6)
- BRCA1 and BRCA2 in Mammary Gland Development and Tumorigenesis (1998) (5)
- Genome wide conditional mouse knockout resources (2016) (5)
- FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle (2020) (5)
- PiggyBac Transposon-Based Insertional Mutagenesis in Mice. (2018) (5)
- ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks (2019) (5)
- Generation and maintenance of Dmbx1 gene-targeted mutant alleles (2006) (4)
- IgA deficient mice show altered immunoglobulin isotype expression and mucosal antibody responses (1996) (4)
- Crafting rat genomes with zinc fingers (2010) (4)
- Mannosidase 2, alpha 1 Deficiency Is Associated with Ricin Resistance in Embryonic Stem (ES) Cells (2011) (3)
- Aging phenotype(s) in kidneys of diabetic mice are p66ShcA dependent. (2018) (3)
- Non-animal-derived antibodies: pharma companies respond (2020) (3)
- Chromosome Engineering and ENU Mutagenesis: Their Use for Defining Gene Function (2003) (3)
- A genetic screen for tumor suppressor genes in the mouse. (1996) (3)
- The production of 4,182 mouse lines identifies experimental and biological variables impacting Cas9-mediated mutant mouse line production (2021) (3)
- Cell Stem Cell Resource An Expanded Oct 4 Interaction Network : Implications for Stem Cell Biology , Development , and Disease (3)
- Introduction: Mutant mice in cancer research (1996) (3)
- Deletion of the MAD 2 L 1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma (2017) (3)
- Targeted inactivation of the Gi2 alpha gene with replacement and insertion vectors: analysis in a 96-well plate format. (1994) (3)
- An integrated gene and SSLP BAC map framework of mouse chromosome 11. (1999) (3)
- Transgenics at breaking-point. (2003) (2)
- Developmental potential of murine pluripotential stem cells. (1991) (2)
- BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1. (2000) (2)
- Erratum: Transposon-mediated genome manipulation in vertebrates (2009) (2)
- to our knowledge base. As always, many new directions morphogenetic protein-7 during development of the mammalian can be proposed. BMP-7 has been proposed as a thera- kidney and eye. Genes Dev 9:2795-2807, 1995 (2000) (1)
- Analysis of Tumor Suppressor Genes Using Transgenic Mice (1995) (1)
- Targeting of the Gi2 alpha gene in ES cells with replacement and insertion vectors. (1993) (1)
- Development and application of a next-generation sequencing protocol and bioinformatics pipeline for the comprehensive analysis of the canine immunoglobulin repertoire (2022) (1)
- Identification and characterization of a microsatellite marker within murine Brca2 gene (2009) (1)
- Generation of mice with deficiency of complement factor H and the complement factor H-related proteins (2016) (1)
- Transcription Units Identification of Mammalian microRNA Host Genes and (2008) (1)
- A FULLY Human Bispecific Antibody Functionally Rescues Factor VIII Deficiency EX VIVO (2019) (1)
- The use of DNA transposons for cancer gene discovery in mice. (2010) (1)
- Deficient mice fail to develop glomeruli and have skeletal patterning defect (1995) (1)
- High-density P300 enhancers control cell state transitions (2015) (1)
- miR-200 deficiency promotes lung cancer metastasis by activating cancer-associated fibroblasts (2020) (1)
- Mouse Models of Cancer (2005) (1)
- A Bradley embryonic stem cells . Recycling selectable markers in mouse (1996) (1)
- Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies (2020) (1)
- PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice (2019) (0)
- Author Correction: Revealing hidden complexities of genomic rearrangements generated with Cas9 (2018) (0)
- TheRoleandFateofDNA EndsforHomologous Recombination in Embryonic StemCells (1992) (0)
- Rapid screening for novel bone phenotypes in 100 consecutive lines from the Wellcome Trust Sanger Institute Gene Targeting Programme (2010) (0)
- An indexed library of cells containing the genomic modifications and to methods for making and using the same (1997) (0)
- Towards Cell Based Therapy For Alpha1-Antitrypsin Deficiency Through Bi-Allelic Gene Correction In Human IPS Cells (2011) (0)
- Abstract P158: MicroRNA-22 Modulates Cardiac Gene Expression and Controls Compensation to Hemodynamic Stress in Mice (2011) (0)
- Chromosomal transposition of a Tc1ymariner-like element in mouse embryonic stem cells (transposon) (1998) (0)
- Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries (2017) (0)
- Allan Bradley discusses mice, men and genetics (2004) (0)
- The mammalian gene function resource: the international knockout mouse consortium (2012) (0)
- P84 Towards cell based therapy for α1-antitrypsin deficiency through targeted bi-allelic gene correction in human iPS cells (2011) (0)
- Differential regulation of activation and differentiation processes in CD4+ T cell populations and their single-cell level heterogeneity (2018) (0)
- A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction (2017) (0)
- Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project (2012) (0)
- Author response: Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma (2017) (0)
- Carcinogenesis in transgenic mouse models (2006) (0)
- A process for the site-specific recombination, rodents and rodent cells capable of expressing the chimeric antibodies or chains (2010) (0)
- Elucidating the activation mechanisms for bifurcation of regulatory and effector T cell fates by multidimensional single cell analysis (2018) (0)
- Gαi2-Deficient Mice Develop Ulcerative Colitis and Adenocarcinoma of the Colon (1996) (0)
- Comprehensive annotation and evolutionary insights into the canine (Canis lupus familiaris) antigen receptor loci (2017) (0)
- Evolutionary trajectories and KRAS gene dosage define pancreatic cancer phenotypes (2018) (0)
- Abstracts from the 3rd Conference on Aneuploidy and Cancer: Clinical and Experimental Aspects (2017) (0)
- Alterations in Expression of Other Ig Isotypes in Mice Leads to IgA Deficiency with Targeted Deletion of the IgA Constant Region (1999) (0)
- Abstract 1158: Modulation of splicing by inhibiting the kinase SRPK1 as a novel therapeutic strategy in myeloid leukemia (2017) (0)
- USING MOUSE MUTAGENESIS TO MODEL HUMAN DISEASE AND DEFINE MAMMALIAN GENE FUNCTION: 280 (2004) (0)
- TOWARDS CELL BASED THERAPY FOR alpha 1-ANTITRYPSIN DEFICIENCY THROUGH TARGETED BI-ALLELIC GENE CORRECTION IN HUMAN IPS CELLS (2011) (0)
- PF338 DEVELOPMENT AND OPTIMISATION OF A FULLY HUMAN FVIII MIMETIC BISPECIFIC ANTIBODY FOR PATIENTS WITH HAEMOPHILIA A (2019) (0)
- Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome (2022) (0)
- PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas (2020) (0)
- Abstracts from the 3rd Conference on Aneuploidy and Cancer: Clinical and Experimental Aspects (2017) (0)
- S851 A FULLY HUMAN BISPECIFIC ANTIBODY FUNCTIONALLY RESCUES FACTOR VIII DEFICIENCY EX VIVO (2019) (0)
- Role of Hoxb-1 during hindbrain specification (1997) (0)
- The genetics and expression of canine antigen receptors analysed with a novel RNA-seq strategy. (2017) (0)
- In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution (2023) (0)
- FAMIN is a purine nucleoside enzyme that paces cellular metabolism via the purine nucleotide cycle (2020) (0)
- Abstracts of papers presented at the 1998 Meeting on Mouse Molecular Genetics, September 2-September 6, 1998 (1998) (0)
- Modelling human microdeletion syndromes by chromosome engineering in mice (2008) (0)
- TheLength ofHomology Required forGeneTargeting inEmbryonic StemCells (1991) (0)
- Characterization of the functional role of mdm2 in development and in tumorigenesis (1994) (0)
- Antony Rodriguez for Normal Immune Function bic / microRNA-155 Requirement (2011) (0)
- Author Correction: Revealing hidden complexities of genomic rearrangements generated with Cas9 (2018) (0)
- Investigation ofCoelectroporation as a MethodforIntroducing SmallMutations intoEmbryonic StemCells (1992) (0)
- Extracting Function from the Mouse Genome (2000) (0)
- Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies (2016) (0)
- In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma (2022) (0)
- Targeted disruption of the muring RAD50 genomic locus results in embryonic lethality. An astro research fellowship presentation (1998) (0)
- Roland Rad Discovery in Mice Transposon Mutagenesis : A Tool for Cancer Gene PiggyBac (2013) (0)
- Intronization enhances expression of S-protein and other transgenes challenged by cryptic splicing (2021) (0)
- Erratum: Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells (Nature (1991) 350 (243-246)) (1991) (0)
- Indexed cell-library with genomic changes and methods for their preparation and use (1997) (0)
- Tissue Specific Chromosome Deletions: An In Vivo Genetic Screen for Tumor Suppressor Genes in the Mammary Glands (1999) (0)
- Abstract 391: Evolutionary trajectories andKRASgene dosage define pancreatic cancer phenotypes (2018) (0)
- recombination in embryonic stem cells. The role and fate of DNA ends for homologous (2013) (0)
- Identification of genetic elements in metabolism by high-throughput mouse phenotyping (2018) (0)
- Mouse FHRB interacts with renal-bound C3 in vivo: Implications for C3 glomerulopathy (2017) (0)
- Abstracts of papers presented at the 1998 Workshop on Conditional Genetic Technologies in the Mouse, August 31-September 2, 1998 (1998) (0)
- Revealing hidden complexities of genomic rearrangements generated with Cas9 (2017) (0)
- Functional genomic studies of cancer immune evasion using in vitro and in vivo CRISPR/Cas9 genetic screens (2022) (0)
- SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 (2018) (0)
- Has the chimpanzee Y chromosome been sequenced (2006) (0)
- Use of CRISPR–cas9 gene targeting for genome-scale CRISPR screening in a glioma stem-cell line (2016) (0)
- Correction to: PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas (2020) (0)
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What Schools Are Affiliated With Allan Bradley?
Allan Bradley is affiliated with the following schools:
