Alun Davies
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British biologist
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Biology
Alun Davies 's Degrees
- Bachelors Biology University of Oxford
- PhD Evolutionary Biology Imperial College London
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Why Is Alun Davies Influential?
(Suggest an Edit or Addition)According to Wikipedia, Alun Millward Davies FRS FRSE FLSW FMedSci is a Welsh biologist, Distinguished Research Professor, School of Biosciences, Cardiff University, since 2004.
Alun Davies 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. (1994) (1297)
- Characterization of a multicomponent receptor for GDNF (1996) (1078)
- The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis (1993) (600)
- GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney (1998) (579)
- Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor (1987) (562)
- The role of neurotrophins in the developing nervous system. (1994) (483)
- GDNF is an age-specific survival factor for sensory and autonomic neurons (1995) (418)
- Earliest sensory nerve fibres are guided to peripheral targets by attractants other than nerve growth factor (1983) (372)
- p75-Deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins (1993) (366)
- Novel class of pain drugs based on antagonism of NGF. (2006) (356)
- Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons. (1993) (341)
- Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase (1997) (322)
- p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF. (1994) (279)
- The response of chick sensory neurons to brain-derived neurotrophic factor (1986) (254)
- Intrinsic programmes of growth and survival in developing vertebrate neurons (1994) (243)
- Chemotropic effect of specific target epithelium in the developing mammalian nervous system (1986) (235)
- Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons. (1997) (228)
- Relation of target encounter and neuronal death to nerve growth factor responsiveness in the developing mouse trigeminal ganglion (1984) (227)
- Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF Responses (1998) (212)
- Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice (2008) (206)
- p75-Mediated NF-κB Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor (1999) (205)
- Neurotrophic factors promote the maturation of developing sensory neurons before they become dependent on these factors for survival (1992) (200)
- Regulation of neural process growth, elaboration and structural plasticity by NF-κB (2011) (178)
- Parkinson's disease α-synuclein mutations exhibit defective axonal transport in cultured neurons (2004) (174)
- NF-κB signalling regulates the growth of neural processes in the developing PNS and CNS (2005) (172)
- Regulation of neuronal survival and death by extracellular signals during development (2003) (170)
- Persyn, a Member of the Synuclein Family, Has a Distinct Pattern of Expression in the Developing Nervous System (1998) (169)
- Developmental changes in NT3 signalling via TrkA and TrkB in embryonic neurons. (1995) (167)
- Role of STAT3 and PI 3-Kinase/Akt in Mediating the Survival Actions of Cytokines on Sensory Neurons (2001) (163)
- Different factors from the central nervous system and periphery regulate the survival of sensory neurones (1986) (158)
- Cytokine-Induced Nuclear Factor Kappa B Activation Promotes the Survival of Developing Neurons (2000) (158)
- The Bcl-2 family of proteins, and the regulation of neuronal survival (1995) (154)
- Multiple Roles for Hepatocyte Growth Factor in Sympathetic Neuron Development (1998) (152)
- The neurotrophic hypothesis: where does it stand? (1996) (152)
- GFRα-4 and the tyrosine kinase Ret form a functional receptor complex for persephin (1998) (149)
- Negative regulation of PI 3‐kinase by Ruk, a novel adaptor protein (2000) (148)
- Coupling Met to specific pathways results in distinct developmental outcomes. (2001) (144)
- Induction of neuronal death by α‐synuclein (2000) (135)
- The duration of neurotrophic factor independence in early sensory neurons is matched to the time course of target field innervation (1991) (133)
- Organization, expression and polymorphism of the human persyn gene. (1998) (127)
- Expression and function of TrkB variants in developing sensory neurons. (1996) (124)
- Persyn, a member of the synuclein family, influences neurofilament network integrity (1998) (124)
- Expression of the NGF receptor gene in sensory neurons and their cutaneous targets prior to and during innervation (1990) (119)
- Neurotrophic factors and neuronal death. (2007) (116)
- Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor (2008) (115)
- Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling. (1996) (115)
- Role of PI 3-kinase, Akt and Bcl-2–related proteins in sustaining the survival of neurotrophic factor–independent adult sympathetic neurons (2001) (115)
- The cranial sensory ganglia in culture: Differences in the response of placode-derived and neural crest-derived neurons to nerve growth factor☆ (1985) (114)
- Inhibition of protein synthesis prevents cell death in sensory and parasympathetic neurons deprived of neurotrophic factor in vitro. (1990) (108)
- Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trkA in developing sensory neurons. (1993) (104)
- TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons (1998) (104)
- Transforming growth factor‐βs inhibit mitogen‐stimulated proliferation of astrocytes (1993) (103)
- Neurotrophin switching: where does it stand? (1997) (102)
- The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-κB signaling (2004) (100)
- Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors. (1996) (98)
- Neurotrophins: Neurotrophic modulation of neurite growth (2000) (97)
- A fast and accurate procedure for deriving the Sholl profile in quantitative studies of neuronal morphology (2007) (95)
- Nuclear Factor κB Signaling Either Stimulates or Inhibits Neurite Growth Depending on the Phosphorylation Status of p65/RelA (2008) (94)
- Molecular and cellular aspects of patterning sensory neurone connections in the vertebrate nervous system. (1987) (94)
- Regulation of nerve growth factor receptor gene expression in sympathetic neurons during development (1995) (92)
- GFRα-4, a New GDNF Family Receptor (1998) (92)
- The survival and growth of embryonic proprioceptive neurons is promoted by a factor present in skeletal muscle. (1986) (92)
- Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons (2008) (90)
- HGF regulates the development of cortical pyramidal dendrites (2004) (89)
- Sympathetic neuron survival and TrkA expression in NT3‐deficient mouse embryos (1997) (89)
- Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue (2018) (88)
- Role of Bcl‐2 in the Brain‐derived Neurotrophic Factor Survival Response (1995) (86)
- Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth (2005) (86)
- Neurotrophic Factors: Switching neurotrophin dependence (1994) (85)
- Neurotrophins: A Ticket to Ride for BDNF (2005) (84)
- Intracellular calcium regulates the survival of early sensory neurons before they become dependent on neurotrophic factors (1992) (83)
- Intrinsic differences in the growth rate of early nerve fibres related to target distance (1989) (79)
- Bcl-2 influences axonal growth rate in embryonic sensory neurons (1997) (78)
- NGF mRNA expression in developing cutaneous epithelium related to innervation density. (1990) (75)
- Neurons Expressing the Highest Levels of γ-Synuclein Are Unaffected by Targeted Inactivation of the Gene (2003) (73)
- The trigeminal system: an advantageous experimental model for studying neuronal development. (1988) (71)
- Multiple effects of artemin on sympathetic neurone generation, survival and growth. (2001) (71)
- Chapter 15 Brain derived neurotrophic factor (1987) (71)
- Role of neurotrophic factors in development. (1988) (71)
- TrkB Variants with Deletions in the Leucine-rich Motifs of the Extracellular Domain* (1997) (70)
- TNFα contributes to the death of NGF-dependent neurons during development (2001) (69)
- NGF-promoted axon growth and target innervation requires GITRL-GITR signaling (2008) (67)
- HGF promotes survival and growth of maturing sympathetic neurons by PI-3 kinase- and MAP kinase-dependent mechanisms (2004) (67)
- Neural crest-derived proprioceptive neurons express nerve growth factor receptors but are not supported by nerve growth factor in culture (1987) (65)
- The survival of NGF-dependent but not BDNF-dependent cranial sensory neurons is promoted by several different neurotrophins early in their development. (1994) (64)
- The emerging generality of the neurotrophic hypothesis (1988) (61)
- Neurotrophic Factors: Neurotrophin autocrine loops (1995) (59)
- Trigeminal sensory neurons require extrinsic signals to switch neurotrophin dependence during the early stages of target field innervation. (1995) (58)
- TNFα reverse signaling promotes sympathetic axon growth and target innervation (2013) (57)
- Differences and Similarities in the Neurotrophic Growth Factor Requirements of Sensory Neurons Derived from Neural Crest and Neural Placode (1985) (55)
- Cytokines promote the survival of mouse cranial sensory neurones at different developmental stages (1998) (52)
- GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. (1998) (52)
- Neuronal survival: Early dependence on Schwann cells (1998) (51)
- Ectopic trkA expression mediates a NGF survival response in NGF- independent sensory neurons but not in parasympathetic neurons (1993) (50)
- Localization of nerve growth factor (NGF) and low‐affinity NGF receptors in touch domes and quantification of NGF mRNA in keratinocytes of adult rats (1994) (50)
- Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development. (1994) (50)
- Developmental changes in the response of trigeminal neurons to neurotrophins: influence of birthdate and the ganglion environment. (1999) (48)
- Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development. (1997) (48)
- NGF Binding to p75 Enhances the Sensitivity of Sensory and Sympathetic Neurons to NGF at Different Stages of Development (1997) (48)
- Homeodomain-Interacting Protein Kinase-2 Regulates Apoptosis in Developing Sensory and Sympathetic Neurons (2004) (46)
- TNFalpha contributes to the death of NGF-dependent neurons during development. (2001) (46)
- Developmental switch in NF-κB signalling required for neurite growth (2009) (45)
- Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival. (2001) (45)
- Nuclear Factor-κB Activation via Tyrosine Phosphorylation of Inhibitor κB-α Is Crucial for Ciliary Neurotrophic Factor-Promoted Neurite Growth from Developing Neurons (2007) (44)
- Studies of neurotrophin biology in the developing trigeminal system (1997) (44)
- Bcl-2 Accelerates the Maturation of Early Sensory Neurons (1998) (42)
- The role of neurotrophins during successive stages of sensory neuron development. (1994) (42)
- Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo. (2001) (42)
- Fasciculation in the early mouse trigeminal nerve is not ordered in relation to the emerging pattern of whisker follicles (1986) (42)
- Heterotopic transplantation of presumptive placodal ectoderm changes the fate of sensory neuron precursors. (1993) (40)
- Paracrine Interactions of BDNF Involving NGF-Dependent Embryonic Sensory Neurons (1996) (40)
- Differences and Developmental Changes in the Responsiveness of PNS Neurons to GDNF and Neurturin (1999) (39)
- Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins (1994) (39)
- Ontogeny of the somatosensory system: origins and early development of primary sensory neurons. (1990) (38)
- Developmental Regulation of Sensory Neurite Growth by the Tumor Necrosis Factor Superfamily Member LIGHT (2009) (38)
- Neural crest-derived spinal and cranial sensory neurones are equally sensitive to NGF but differ in their response to tissue extracts. (1984) (37)
- Cooperation between HGF and CNTF in Promoting the Survival and Growth of Sensory and Parasympathetic Neurons (2000) (37)
- Influence of nerve growth factor on the embryonic mouse trigeminal ganglion in culture. (1981) (35)
- Regulation of Neurotrophin Receptor Expression by Retinoic Acid in Mouse Sympathetic Neuroblasts (1999) (35)
- Influence of nerve growth factor on developing dorso-medial and ventro-lateral neurons of chick and mouse trigeminal ganglia (1983) (34)
- Developmentally regulated expression of persyn, a member of the synuclein family, in skin. (1999) (33)
- GFRalpha-4, a new GDNF family receptor. (1998) (33)
- Nerve growth factor synthesis and nerve growth factor receptor expression in neural development. (1991) (31)
- Regulation of neurite growth by tumour necrosis superfamily member RANKL (2013) (31)
- Timing and Regulation of trkB and BDNF mRNA Expression in Placode‐derived Sensory Neurons and their Targets (1996) (31)
- Selective Regulation of trkC Expression by NT3 in the Developing Peripheral Nervous System (1999) (30)
- NGF receptor expression in sensory neurons develops normally in embryos lacking NGF. (1995) (30)
- Paracrine and autocrine actions of neurotrophic factors (1996) (29)
- Extracellular signals regulating sympathetic neuron survival and target innervation during development (2009) (28)
- Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation (2016) (28)
- Intracellular Compartmentalization of Two Differentially Spliceds-rex/NSPmRNAs in Neurons (1996) (28)
- Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL (2014) (26)
- Neurotrophins: More to NGF than just survival (2000) (26)
- Neurotrophins: The yin and yang of nerve growth factor (1997) (25)
- ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism (2013) (24)
- Differences in Bcl‐2‐ and Bax‐independent function in regulating apoptosis in sensory neuron populations (2000) (24)
- Protein Tyrosine Phosphatase Receptor Type O Inhibits Trigeminal Axon Growth and Branching by Repressing TrkB and Ret Signaling (2013) (24)
- Chicken synucleins: cloning and expression in the developing embryo (2000) (23)
- HAND transcription factors are required for neonatal sympathetic neuron survival (2008) (22)
- In vivo survival requirement of a subset of nodose ganglion neurons for nerve growth factor (2000) (22)
- CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons (2017) (21)
- Age-Dependent Maintenance of Motor Controland Corticostriatal Innervation by Death Receptor 3 (2010) (21)
- TrkB expression and early sensory neuron survival are independent of endogenous BDNF (2000) (21)
- Regulation of Autocrine Signaling in Subsets of Sympathetic Neurons Has Regional Effects on Tissue Innervation (2015) (21)
- A function for the calponin family member NP25 in neurite outgrowth. (2008) (20)
- Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development (2013) (20)
- Mutations in the gene encoding human persyn are not associated with amyotrophic lateral sclerosis or familial Parkinson's disease (1999) (20)
- The growth rate of sensory nerve fibres in the mammalian embryo. (1987) (19)
- An essential role for neuregulin-4 in the growth and elaboration of developing neocortical pyramidal dendrites (2018) (19)
- The Death Receptor Antagonist FLIP-L Interacts with Trk and Is Necessary for Neurite Outgrowth Induced by Neurotrophins (2010) (18)
- Age‐related effects of nerve growth factor on the morphology of embryonic sensory neurons in vitro (1993) (18)
- Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons (2003) (18)
- The intracellular portion of GITR enhances NGF-promoted neurite growth through an inverse modulation of Erk and NF-κB signalling (2012) (17)
- ERK signaling mediates CaSR-promoted axon growth (2015) (17)
- Developmental changes in the neurotrophic factor survival requirements of peripheral nervous system neurons. (1998) (17)
- Brain derived neurotrophic factor. (1990) (15)
- The monoclonal antibody 69A1 recognizes an epitope found on neurones with axons that fasciculate but not on those with non-fasciculating processes. (1987) (14)
- Depolarisation causes reciprocal changes in GFR(alpha)-1 and GFR(alpha)-2 receptor expression and shifts responsiveness to GDNF and neurturin in developing neurons. (2000) (14)
- Faculty of 1000 evaluation for Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-kappaB signaling. (2011) (13)
- Coordination of trophic interactions by separate developmental programs in sensory neurons and their target fields (1991) (13)
- T-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling (2017) (13)
- Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3 (2008) (12)
- Leukemia inhibitory factor and ciliary neurotrophic factor in sensory neuron development. (1996) (12)
- Macrophage‐stimulating protein is a neurotrophic factor for embryonic chicken hypoglossal motoneurons (2002) (11)
- TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo (2017) (11)
- Neural Development: Chemoattractants for navigating axons (1994) (10)
- Identifying Components of Max Factor (1999) (10)
- TWE-PRIL reverse signalling suppresses sympathetic axon growth and tissue innervation (2018) (10)
- High Specificity of Neurotrophins in the Embryonic Chicken Trigeminal System (1995) (9)
- Neurotrophins giveth and they taketh away (2008) (9)
- Retinoic acid negatively regulates GDNF and neurturin receptor expression and responsiveness in embryonic chicken sympathetic neurons (2005) (9)
- CD40 forward signalling is a physiological regulator of early sensory axon growth (2019) (8)
- Regional Differences in the Contributions of TNF Reverse and Forward Signaling to the Establishment of Sympathetic Innervation (2019) (7)
- Macrophage stimulating protein is a neurotrophic factor for a sub-population of adult nociceptive sensory neurons (2009) (7)
- Genomic structure and chromosomal localization of the mouse persyn gene. (1999) (7)
- NGF synthesis and NGF receptor expression in the embryonic mouse trigeminal system. (1990) (7)
- Neuregulin-4 Is Required for the Growth and Elaboration of Striatal Medium Spiny Neuron Dendrites (2019) (7)
- Promoting motor neuron survival (1993) (6)
- Selective regulation of nerve growth factor expression in developing cutaneous tissue by early sensory innervation (2011) (5)
- 51 Timing of neuronal death in trkA, trkB and trkc mutant embryos demonstrates neurotrophin switching in developing trigeminal neurons (1996) (5)
- Chemotropic Influence of Specific Target Epithelium on the Growth of Embryonic Sensory Neurites (1988) (4)
- TrkA mediates an NGF survival response in NGF-independent sensory neurons but not in parasympathetic neurons. (1994) (4)
- Neurite outgrowth from murine sensory ganglia cultured in a serumless medium. (1981) (4)
- CD40L Reverse Signaling Influences Dendrite Spine Morphology and Expression of PSD-95 and Rho Small GTPases (2020) (3)
- CD40L reverse signaling suppresses prevertebral sympathetic axon growth and tissue innervation (2019) (3)
- How CD40L reverse signaling regulates axon and dendrite growth (2020) (3)
- Gene probes (methods in neuroscience, vol. 1): edited by P.M. Conn, Academic Press, 1989. $61.00 (xiii + 464 pages) ISBN 0 12 185251 2 (1991) (2)
- Chemoattractants for navigating axons Newly identified proteins that seem to act as diffusible attractants for circumferentially growing axons in the vertebrate embryonic spinal cord are related to a protein that directs circumferential axon growth in the nematode. (1994) (2)
- CD40L/CD40 bidirectional signaling is a major regulator of neuronal morphology in the developing nervous system (2021) (2)
- The 3rd German-Japanese Joint Workshop. Cell Death in the CNS: Molecules and Programs (1996) (2)
- Faculty Opinions recommendation of Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. (2001) (1)
- Neurotrophin-independent survival and cell death in adult sympathetic neurons: the role of PI 3-kinase (2000) (1)
- Developmental programmes of growth and survival in early sensory neurons. (1991) (1)
- Faculty Opinions recommendation of Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. (2010) (1)
- Erratum: GDNF: A Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle (1995) (1)
- Regulation of Neuronal Survival by Neurotrophins in the Developing Peripheral Nervous System (2013) (1)
- Neuregulin‐4 contributes to the establishment of cutaneous sensory innervation (2020) (1)
- Neuregulin-4 Is Required for Maintaining Soma Size of Pyramidal Neurons in the Motor Cortex (2021) (1)
- Glucose Tolerance by Uteroplacental Insufficiency in Male Rat Offspring Improved Lactational Nutrition and Postnatal Growth Ameliorates Impairment of (2008) (1)
- Signalling Pathways Mediating the Effects of CD40-Activated CD40L Reverse Signalling on Inhibitory Medium Spiny Neuron Neurite Growth (2021) (1)
- Faculty Opinions recommendation of Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. (2009) (0)
- Developmental Neuroscience (2005) (0)
- Recent work has shown that the survival of the nerve growth factor (NGF)-dependent trigeminal ganglion neurons of the mouse embryo is promoted by brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) during the early stages of target field innervation (1994) (0)
- Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation (2016) (0)
- Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue (2018) (0)
- The Development of Primary Sensory Neurons (1990) (0)
- Author response: CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons (2017) (0)
- Initial axon growth rate from embryonic sensory neurons is correlated with birth date (2020) (0)
- How CD40L reverse signaling regulates axon and dendrite growth (2020) (0)
- Reward Activates Primary Somatosensory Cortex (2008) (0)
- Faculty Opinions recommendation of Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. (2001) (0)
- Sympathetic neuron survival and TrkA expression in NT 3-deficient mouse embryos trophins for survival at an earlier stage in their (2013) (0)
- Particle-Mediated Gene Transfer in Retinal Explant Cultures as a Model for Studying Neurite Remodelling After Axotomy (2008) (0)
- Sympathetic neurons which are vulnerable to ageing project to targets with low levels of neurotrophin expression and exhibit reduced plasticity of neurotrophin receptor expression (2002) (0)
- Faculty Opinions recommendation of Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. (2001) (0)
- Table of Contents (1996) (0)
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