Amanda Fosang
#79,444
Most Influential Person Now
Australian biomedical researcher
Amanda Fosang's AcademicInfluence.com Rankings
Amanda Fosanglaw Degrees
Law
#2915
World Rank
#3644
Historical Rank
Common Law
#201
World Rank
#218
Historical Rank
Amanda Fosangbiology Degrees
Biology
#14210
World Rank
#17908
Historical Rank
Cell Biology
#843
World Rank
#863
Historical Rank
Molecular Biology
#2578
World Rank
#2619
Historical Rank
Download Badge
Law Biology
Amanda Fosang's Degrees
- PhD Biomedical Science University of Melbourne
Why Is Amanda Fosang Influential?
(Suggest an Edit or Addition)According to Wikipedia, Amanda Jane Fosang is a biomedical researcher who has pioneered arthritis research in Australia. Career Fosang is a principal research fellow with the National Health and Medical Research Council of Australia who has an established career researching arthritis and cartilage biology in health and disease. She is professor and group leader of arthritis research at the Murdoch Childrens Research Institute and the University of Melbourne Department of Paediatrics. Fosang returned to Australia after completing her post-doctoral studies at the Kennedy Institute of Rheumatology in London, and was awarded an RD Wright Fellowship by the NHMRC in 1994. Since then she has received continuous competitive grant and fellowship funding from the NHMRC. She joined the University of Melbourne, Department of Medicine in 1990, and moved to the Department of Paediatrics in 1994. Fosang became a group leader of the MCRI at its inception in 2000.
Amanda Fosang's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Proteoglycans: many forms and many functions (1992) (1163)
- ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro (2005) (879)
- Altered endochondral bone development in matrix metalloproteinase 13-deficient mice (2004) (595)
- Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. (2009) (548)
- Degradation of cartilage aggrecan by collagenase‐3 (MMP‐13) (1996) (393)
- The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B. (1992) (280)
- Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro. (1995) (216)
- Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent. (1996) (211)
- Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. (2007) (204)
- Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity (2007) (179)
- Hyaluronan synthesis and degradation in cartilage and bone (2008) (172)
- Proteoglycan degradation by the ADAMTS family of proteinases. (2011) (171)
- Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins. (1991) (160)
- Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain. (1993) (151)
- Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP) (2000) (140)
- The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases. (2002) (119)
- An ELISA plate-based assay for hyaluronan using biotinylated proteoglycan G1 domain (HA-binding region). (1990) (119)
- ADAMTS-5: the story so far. (2008) (118)
- Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan. (1994) (118)
- Insulin-like growth factor binding protein-2 binds to cell surface proteoglycans in the rat brain olfactory bulb. (1997) (113)
- Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids. (1995) (109)
- ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. (2005) (105)
- Drug Insight: aggrecanases as therapeutic targets for osteoarthritis (2008) (98)
- Effect of interleukin-1 and insulin like growth factor-1 on the release of proteoglycan components and hyaluronan from pig articular cartilage in explant culture. (1991) (96)
- Isolation of the N-terminal globular protein domains from cartilage proteoglycans. Identification of G2 domain and its lack of interaction with hyaluronate and link protein. (1989) (90)
- ADAMTS4 Cleaves at the Aggrecanase Site (Glu373-Ala374) and Secondarily at the Matrix Metalloproteinase Site (Asn341-Phe342) in the Aggrecan Interglobular Domain* (2002) (90)
- The structure, function and turnover of aggrecan, the large aggregating proteoglycan from cartilage. (1994) (87)
- Role and regulation of metalloproteinases in connective tissue turnover. (1990) (86)
- 3D Bioprinting of Cartilage for Orthopedic Surgeons: Reading between the Lines (2015) (84)
- The structure of aggrecan and its turnover in cartilage. (1995) (74)
- Emerging Frontiers in cartilage and chondrocyte biology. (2011) (74)
- Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis? (2010) (72)
- Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation. (2007) (72)
- Transparency Is the Key to Quality (2015) (71)
- Immunolocalization of Matrix Metalloproteinases in Partial-Thickness Defects in Pig Articular Cartilage: A Preliminary Report (2001) (69)
- An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2. (2018) (68)
- Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage (2011) (68)
- Bioactivity in an Aggrecan 32‐mer Fragment Is Mediated via Toll‐like Receptor 2 (2015) (65)
- Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5. (2008) (63)
- ADAMTS-5 Deficiency Does Not Block Aggrecanolysis at Preferred Cleavage Sites in the Chondroitin Sulfate-rich Region of Aggrecan* (2007) (62)
- Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction. (2013) (60)
- Proteomic characterization of mouse cartilage degradation in vitro. (2008) (59)
- Identifying the human aggrecanase. (2010) (58)
- MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays. (2007) (57)
- Reduction of arthritis severity in protease-activated receptor-deficient mice. (2005) (57)
- Increased hyaluronan production in the glomeruli from diabetic rats: a link between glucose-induced prostaglandin production and reduced sulphated proteoglycan (1995) (56)
- Pregnancy-related changes in the connective tissue of the ovine cervix. (1984) (55)
- Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan (2005) (51)
- Matrix Metalloproteinases Are Not Essential for Aggrecan Turnover during Normal Skeletal Growth and Development (2005) (50)
- Employing molecular genetics of chondrodysplasias to inform the study of osteoarthritis. (2009) (49)
- Brief Report: JNK‐2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis (2015) (47)
- Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice. (2010) (46)
- Proteoglycans isolated from dissociative extracts of differently aged human articular cartilage: characterization of naturally occurring hyaluronan-binding fragments of aggrecan. (1994) (40)
- Neoepitopes as biomarkers of cartilage catabolism (2003) (39)
- High-bandwidth AFM-based rheology is a sensitive indicator of early cartilage aggrecan degradation relevant to mouse models of osteoarthritis. (2014) (35)
- Mast Cell–Restricted, Tetramer-Forming Tryptases Induce Aggrecanolysis in Articular Cartilage by Activating Matrix Metalloproteinase-3 and -13 Zymogens (2013) (33)
- Novel Elements of the Chondrocyte Stress Response Identified Using an in Vitro Model of Mouse Cartilage Degradation. (2016) (32)
- Distinguishing Aggrecan Loss from Aggrecan Proteolysis in ADAMTS-4 and ADAMTS-5 Single and Double Deficient Mice* (2007) (31)
- ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures. (2006) (30)
- N-Linked Keratan Sulfate in the Aggrecan Interglobular Domain Potentiates Aggrecanase Activity* (2005) (29)
- Changes in versican and chondroitin sulfate proteoglycans during structural development of the lung. (2007) (29)
- The accumulation of intracellular ITEGE and DIPEN neoepitopes in bovine articular chondrocytes is mediated by CD44 internalization of hyaluronan. (2006) (28)
- Cortisol enhances structural maturation of the hypoplastic fetal lung in sheep (2004) (27)
- The sulphation pattern in chondroitin sulphate chains investigated by chondroitinase ABC and ACII digestion and reactivity with monoclonal antibodies. (1994) (26)
- Adamts5-/- Mice Exhibit Altered Acan (Aggrecan) Proteolytic Profiles That Correlate With Ascending Aortic Anomalies. (2019) (26)
- Internalization of Aggrecan G1 Domain Neoepitope ITEGE in Chondrocytes Requires CD44* (2010) (26)
- 1-C-6 epitope in cartilage proteoglycan G2 domain is masked by keratan sulphate. (1991) (25)
- Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan. (2010) (25)
- Human genetics: To clot or not (2001) (20)
- Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage. (2008) (20)
- Cartilage MicroRNA Dysregulation During the Onset and Progression of Mouse Osteoarthritis Is Independent of Aggrecanolysis and Overlaps With Candidates From End‐Stage Human Disease (2018) (19)
- Connective tissue remodelling in the ovine cervix during pregnancy and at term. (1988) (18)
- Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo (2012) (16)
- Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus. (2012) (15)
- Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2a1-Cre; ROSA26RLacZ reporter mice. (2013) (14)
- Matrix metalloproteinases are active following guanidine hydrochloride extraction of cartilage: generation of DIPEN neoepitope during dialysis. (2002) (14)
- Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth (2019) (13)
- Gelatinase A possesses a beta-secretase-like activity in cleaving the amyloid protein precursor of Alzheimer's disease. (1995) (13)
- Domain structure in aggregating proteoglycans from cartilage. (1990) (12)
- Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan. (2009) (12)
- Characterization of proteoglycans isolated from associative extracts of human articular cartilage. (1993) (12)
- A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers* (2015) (12)
- Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state. (2011) (11)
- The role of hepatocyte growth factor in the humoral regulation of inguinal hernia closure. (2005) (11)
- ADAMTS-5 takes centre stage in new developments for aggrecanase inhibitors. (2015) (9)
- Proteoglycan and Collagen Degradation in Osteoarthritis (2017) (9)
- ADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5 (2019) (8)
- Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs. (2019) (8)
- Domain structure and sequence similarities in cartilage proteoglycan. (1990) (5)
- IGFBP-2/IGF-I/Proteoglycan complexes in the rat brain olfactory bulb (2004) (5)
- Antibodies to MMP-cleaved aggrecan. (2001) (5)
- Glucocorticoids influence versican and chondroitin sulphate proteoglycan levels in the fetal sheep lung (2018) (5)
- ADAMTS-5 activity in synovial fibroblasts is different to chondrocytes (2007) (4)
- Aggrecanase and cartilage proteoglycan degradation (1999) (4)
- Erratum to “MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays” [Osteoarthritis Cartilage 15 (2007) 212–21] (2007) (3)
- Bioactivity in an aggrecan 32mer fragment is mediated via toll-like receptors (2014) (3)
- Degradative mechanisms in mouse articular cartilage:use of in vitro models to analyse proteolysis and loss of aggrecan and link protein (2003) (3)
- A 32-mer fragment of aggrecan promotes knee hyperalgesia in the DMM model of osteoarthritis through direct nociceptor activation via TLR2 (2016) (2)
- GSK-3beta in mouse fibroblast controls wound healing and fibrosis through an endothelin-1-dependent mechanism. (2008) (2)
- An aggrecan 32-mer fragment generated in osteoarthritis directly excites nociceptive neurons (2015) (2)
- Insulin-like growth factors : implications for the CNS (1998) (2)
- SP0022 Knock-in mice reveal in vivo consequences of MMP activity for OA (2013) (1)
- Disturbed endochondral ossification in collagen II knockin mice resistant to collagenase cleavage (2009) (1)
- Defining the relationship between joint pathology and pain in osteoarthritis using genetically modified mice (2016) (1)
- 475 PROTEOMIC CHARACTERIZATION OF MOUSE CARTILAGE DEGRADATION IN VITRO (2008) (1)
- Proteomic analysis of mouse cartilage degradation in vitro (2007) (0)
- A 32-Mer Aggrecan Fragment Generated through Adamts-4/5 and MMP-Mediated Cleavage Can Directly Excite Nociceptive Neurons (2015) (0)
- The Role of Matrix Turnover on Differentiation of Intervertebral Disk Cells (2014) (0)
- Welcome from the President and Congress Chairs (2010) (0)
- Generation of a mouse model to study ADAMTS-5 as a genetic risk factor for intervertebral disc degeneration (2011) (0)
- The role of an aggrecan 32mer fragment in post-traumatic osteoarthritis (2017) (0)
- Aggrecan fragments in the synovial fluid of osteoarthritis and juvenile idiopathic arthritis patients reveals differences in the specificity of aggrecanase cleavage in the interglobular domain, but not in the chondroitin-sulphate-rich region (2012) (0)
- Effect of impaired matrix turnover on differentiation of intervertebral disc cells (2013) (0)
- Impact of activating ADAMTS-5 in cartilage-related degenerative disorders (2010) (0)
- Proteomic analysis of cytokine-induced cartilage degradation in normal cartilage and cartilage lacking ADAMTS-5 activity (2014) (0)
- Effect of aggrecanase and collagenase resistant knock-in, age and joint-overuse on murine cartilage (2015) (0)
- Studies on the connective tissue of the ovine cervix (2021) (0)
- Comparison between aggrecan loss and aggrecan precessing in explants of cartilage from ADAMTS-4, ADAMTS-5 and ADAMTS- 4/5 deficient mice. (2007) (0)
- Faculty Opinions recommendation of Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin. (2009) (0)
- Blocking collagenolysis prevents aggrecan loss more effectively than blocking aggrecanolysis in the aggrecan interglobular domain, in vitro and in vivo (2012) (0)
- Association and functional analysis of ADAMTSS in lumbar disc degeneration (2015) (0)
- Proteomic profiling of cartilage degradation in vitro (2008) (0)
- In vitro model to mimic aggrecan fragmentation profiles after spinal cord injury (2019) (0)
- Faculty Opinions recommendation of Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases. (2008) (0)
- An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2 (2017) (0)
- 217 GLOBAL GENE EXPRESSION PROFILING OF EARLY OSTEOARTHRITIS IN WILD-TYPE MICE AND MICE LACKING ADAMTS-5 ACTIVITY (2008) (0)
- Generation of mice with aggrecan resistant to aggrecanase cleavage in the IGD (2005) (0)
- Novel methods for cartilage proteomic analysis (2008) (0)
- A20 MMP-13 KNOCK OUT MICE ARE RESISTANT TO CARTILAGE DAMAGE IN A SURGICAL MODEL OF OSTEOARTHRITIS (2008) (0)
- Role of Type II Collagen Turnover in Disk Development and Degeneration (2012) (0)
- Cartilage microRNA dysregulation during the onset and progression of mouse osteoarthritis overlaps with patient disease candidates (2017) (0)
This paper list is powered by the following services:
Other Resources About Amanda Fosang
What Schools Are Affiliated With Amanda Fosang?
Amanda Fosang is affiliated with the following schools:
