Amanda Swart
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South African biochemist
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Amanda Swartbiology Degrees
Biology
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Biochemistry
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#2847
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Biology
Amanda Swart's Degrees
- Bachelors Biochemistry University of Cape Town
- Masters Biochemistry University of Cape Town
- PhD Biochemistry Stellenbosch University
Why Is Amanda Swart Influential?
(Suggest an Edit or Addition)According to Wikipedia, Amanda Cecilia Swart is a South African biochemist who holds a professorship in biochemistry at Stellenbosch University. She is known for her research on rooibos, a herbal tea popular in South Africa, has been funded by the South African Rooibos Council in her research, and is frequently quoted in South African media promoting the reported health benefits of rooibos.
Amanda Swart's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- 11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer? (2013) (127)
- Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase. (1993) (101)
- The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells (2012) (90)
- Formation of Prothrombin Converting Activity (1967) (79)
- 11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione (2013) (75)
- Melatonin‐Responsive Headache in Delayed Sleep Phase Syndrome: Preliminary Observations (1998) (70)
- Traumatic brain injury-associated delayed sleep phase syndrome. (1997) (60)
- Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone (2017) (52)
- 11β-hydroxyandrostenedione: Downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathways (2015) (52)
- Discovery of Compound A – a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity (2015) (51)
- 11β-Hydroxyandrostenedione Returns to the Steroid Arena: Biosynthesis, Metabolism and Function (2013) (48)
- A single amino acid residue, Ala 105, confers 16α-hydroxylase activity to human cytochrome P450 17α-hydroxylase/17,20 lyase (2010) (42)
- Advances in the analytical methodologies: Profiling steroids in familiar pathways-challenging dogmas (2015) (42)
- Separation of blood coagulation factors II, VII, IX and X by gel filtration in the presence of dextran blue. (1970) (41)
- The Effect of Sutherlandia frutescens on Steroidogenesis: Confirming Indigenous Wisdom (2004) (39)
- The influence of Sutherlandia frutescens on adrenal steroidogenic cytochrome P450 enzymes. (2008) (38)
- Cytochrome b5: Novel roles in steroidogenesis (2013) (38)
- Functional expression and characterisation of human cytochrome P45017α in Pichia pastoris (2007) (36)
- Long-term follow-up of women enrolled in a randomized trial of adjuvant chemotherapy for early stage ovarian cancer (ICON1) (2007) (33)
- Artificial Reagents for Factor VII and Factor X, a Computer Programme for Obtaining Reference Tables for One-Stage Determinations in the Extrinsic System (1972) (31)
- The development of an ultra performance liquid chromatography-coupled atmospheric pressure chemical ionization mass spectrometry assay for seven adrenal steroids. (2008) (30)
- Biological activities of the shrub Salsola tuberculatiformis Botsch.: contraceptive or stress alleviator? (2003) (29)
- Aspalathus linearis (Rooibos) - a functional food targeting cardiovascular disease. (2018) (29)
- The Identification of Two CYP17 Alleles in the South African Angora Goat (2007) (26)
- Ovine steroid 17alpha-hydroxylase cytochrome P450: characteristics of the hydroxylase and lyase activities of the adrenal cortex enzyme. (2003) (26)
- Rooibos Flavonoids Inhibit the Activity of Key Adrenal Steroidogenic Enzymes, Modulating Steroid Hormone Levels in H295R Cells (2014) (24)
- Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone (2017) (24)
- Cytochrome b5 modulates multiple reactions in steroidogenesis by diverse mechanisms (2015) (24)
- Cytochrome P450 side-chain cleavage: Insights gained from homology modeling (2007) (23)
- The Nature of the Polymeric Serum IgA In Man 1 (1975) (23)
- Inhibition of cytochrome P-450(11)beta by some naturally occurring acetophenones and plant extracts from the shrub Salsola tuberculatiformis. (1993) (22)
- Rooibos (Aspalathus linearis) facilitates an anti-inflammatory state, modulating IL-6 and IL-10 while not inhibiting the acute glucocorticoid response to a mild novel stressor in vivo (2016) (21)
- Inefficient UGT-conjugation of adrenal 11β-hydroxyandrostenedione metabolites highlights C11-oxy C19 steroids as the predominant androgens in prostate cancer (2017) (21)
- 16α-Hydroxyprogesterone: Origin, biosynthesis and receptor interaction (2011) (20)
- A high-throughput UPC2-MS/MS method for the separation and quantification of C19 and C21 steroids and their C11-oxy steroid metabolites in the classical, alternative, backdoor and 11OHA4 steroid pathways. (2018) (20)
- Baboon cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17). (2002) (20)
- Rooibos influences glucocorticoid levels and steroid ratios in vivo and in vitro: a natural approach in the management of stress and metabolic disorders? (2014) (20)
- The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis (2019) (20)
- The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway (2017) (19)
- Homogeneous antibodies in lethally irradiated and autologous bone marrow reconstituted Rhesus monkeys (1976) (15)
- Modulation of glucocorticoid, mineralocorticoid and androgen production in H295 cells by Trimesemine™, a mesembrine-rich Sceletium extract. (2016) (15)
- Falsely elevated plasma testosterone concentrations in neonates: importance of LC-MS/MS measurements (2018) (15)
- The Adsorption of Blood Coagulation Factors II, VII, IX and X from Human Plasma to Aluminium Hydroxide (1972) (14)
- Two CYP17 genes in the South African Angora goat (Capra hircus) – the identification of three genotypes that differ in copy number and steroidogenic output (2008) (14)
- Cytochrome b5 augments 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase activity (2011) (14)
- The 11β-hydroxyandrostenedione pathway and C11-oxy C21 backdoor pathway are active in benign prostatic hyperplasia yielding 11keto-testosterone and 11keto-progesterone (2020) (13)
- The Effect of Soy Isoflavones on Steroid Metabolism (2019) (11)
- CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway (2020) (11)
- SHEEP ADRENAL CYTOCHROME b5: ACTIVE AS A MONOMER OR A TETRAMER IN VIVO? (2002) (11)
- Allosteric interaction between 3β‐hydroxysteroid dehydrogenase/Δ5‐Δ4 isomerase and cytochrome b5 influences cofactor binding (2013) (11)
- Cortisol production in sheep is influenced by the functional expression of two cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17) isoforms. (2013) (11)
- Hypocortisolism in the South African Angora goat: The role of 3βHSD (2010) (11)
- Sutherlandia frutescens modulates adrenal hormone biosynthesis, acts as a selective glucocorticoid receptor agonist (SEGRA) and displays anti-mineralocorticoid properties. (2017) (10)
- CYP17 causes hypocortisolism in the South African Angora goat (2009) (9)
- Functional expression and characterisation of human cytochrome P45017alpha in Pichia pastoris. (2007) (9)
- Cytochrome b5 forms homomeric complexes in living cells (2012) (8)
- Back where it belongs: 11β-hydroxyandrostenedione compels the re-assessment of C11-oxy androgens in steroidogenesis (2021) (8)
- Biologic activities of various thymus preparations. (1977) (7)
- What's in a whisker? High-throughput analysis of twenty-eight C19 and C21 steroids in mammalian whiskers by ultra-performance convergence chromatography-tandem mass spectrometry. (2020) (7)
- Relative contribution of P450c17 towards the acute cortisol response: Lessons from sheep and goats (2015) (7)
- Steroid hormone analysis of adolescents and young women with polycystic ovarian syndrome and adrenocortical dysfunction using UPC2 -MS/MS (2020) (7)
- 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro (2019) (7)
- Effect of various thymic and nonthymic factors on in vitro antibody formation by spleen cells from nude mice. (1978) (6)
- Expression of human P450c17 as an export protein in Saccharomyces cerevisiae. (1995) (6)
- b-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone , novel C 19 steroids with androgenic activity : A putative role in castration resistant prostate cancer ? (2013) (6)
- C11-oxy C19 and C11-oxy C21 steroids in neonates: UPC2-MS/MS quantification of plasma 11β-hydroxyandrostenedione, 11-ketotestosterone and 11-ketoprogesterone (2018) (5)
- BABOON CYP11B1: THE LOCALIZATION AND CATALYTIC ACTIVITY IN BABOON ADRENAL TISSUE (2002) (5)
- Sequence of the 11β-hydroxylase gene from the cape baboon (Papio Ursinus) (1996) (5)
- Analysis of 52 C19 and C21 steroids by UPC2-MS/MS: Characterising the C11-oxy steroid metabolome in serum. (2020) (5)
- The metabolic fate and receptor interaction of 16α-hydroxyprogesterone and its 5α-reduced metabolite, 16α-hydroxy-dihydroprogesterone (2017) (5)
- Differential interaction of clotting factors II, VII, IX and X with sephadex and dextran blue. (1972) (4)
- The Influence of the Amino Acid Substitution I98K on the Catalytic Activity of Baboon Cytochrome P450 Side‐Chain Cleavage (CYP11A1) (2004) (4)
- Micro-assay for sheep 11 beta-hydroxylase activity using high-performance liquid chromatography for steroid analysis. (1988) (3)
- Corrigendum to “The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells” [J. Steroid Biochem. Mol. Biol. 128 (2012) 128–138] (2013) (3)
- Factor IX concentrate : Preparation by a simple method and clinical use (1970) (2)
- Onset of melatonine production before and after treatment with melatonin in patients with delayed sleep phase syndrome (1996) (2)
- [Synchronization of the biological clock in a disordered sleep-wakefulness rythm]. (1996) (2)
- Delayed sleep phase syndrome: a placebo-controlled cross-over study on the effects of melatonin administered 5 hours before dim light melatonin onset (1997) (2)
- Perspective on the regulatory role of UGT2B28 as a conjugating enzyme in the progression of prostate cancer (2016) (2)
- Sequence of the 11 beta-hydroxylase gene from the Cape baboon (Papio ursinus). (1996) (2)
- Rooibos tea: A functional food in the management of metabolic disorders (2014) (2)
- A non-linear reaction scheme of blood coagulation (1974) (1)
- 121: The effect of Salsola tuberculata extracts and Compound A against intracellular interleukin-1alpha (icIL-1α) in the UVB in vitro model for inflammation and chemoprevention in skin (2014) (1)
- Evidence for the functional role of residues in the B′–C loop of baboon cytochrome P450 side-chain cleavage (CYP11A1) obtained by site-directed mutagenesis, kinetic analysis and homology modelling (2007) (1)
- Turning the spotlight on the C11-oxy androgens in human fetal development (2021) (1)
- Ultra-performance convergence chromatography tandem mass spectrometry analysis of adrenal and gonadal steroid hormones in southern white rhinoceros(Ceratotherium simum simum) faeces and serum. (2022) (1)
- The interaction of biogenic amines with adrenal cytochrome P450-dependent enzymes. (1993) (1)
- Characterising The 11β‐hydroxyandrostenedione‐pathway in In Vitro Models (2020) (0)
- [Chronic fatigue syndrome]. (1997) (0)
- SAT-344 11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrgenase Inhibitor, Is Metabolised In Vitro by Adrenal Steroidogenic Enzymes (2019) (0)
- The in vitro inhibition of adrenal steroidogenic enzymes and modulation of adrenal hormone production by Sceletium tortuosum (2018) (0)
- CYP11B and CYP17A1 in the Biosynthesis and Metabolism of C11‐oxy Steroids (2020) (0)
- Contents, Vol. 1, 1972 (1972) (0)
- Computational modelling of the Δ4 and Δ5 adrenal steroidogenic pathways provides insight into hypocortisolism (2021) (0)
- Baboon cytochrome P450 c17 (17[alpha]-hydroxylase/17, 20 lyase) : cDNA cloning from adrenal mRNA and characterisation of the expressed enzyme (1998) (0)
- Formation of Proth rom bin Convert ing Activi (0)
- A biochemical study of two natural products from Salsola tuberculata (1986) (0)
- OR02-5 Novel Intermediates Are Catalysed By 11βHSD And CYP17A1 In The C11-oxy Backdoor Pathway Leading To The Production Of 11-ketodihydrotestosterone (2019) (0)
- [Preservation and transportation of amputated limbs]. (1989) (0)
- Hypo-adrenocorticism and stress intolerance in the Angora Goat: Involvement of cytochrome P450c17. (2006) (0)
- SAT-742 Characterising the Metabolism, Glucuronidation and Sulfation of C11-oxy C19 Steroids (2020) (0)
- LBMON273 Not All Men Are Created Equal (2022) (0)
- Androstenedione Is the Preferred Substrate for Cytochrome P450 11β-hydroxylase Leading to the Production of 11β-Hydroxyandrostenedione in the Adrenal Gland (2021) (0)
- A Novel Method for the Preparation of Substrate-Free Cytochrome P-45011β (1985) (0)
- SAT-019 Clinical Disorders and Diseases Marked by Elevated Adrenal C11-oxy C21 and C11-oxy C19 Steroid Levels (2019) (0)
- THE EFFECT OF VARIOUS THYMIC EXTRACTS ON THE IN VITRO IMMUNE RESPONSE AGAINST SRBC AND ON MITOGEN RESPONSES AND INTRACELLULAR CAMP LEVELS OF T CELLS (1977) (0)
- 11-Hydroxyandrostenedione is metabolised to novel androgenic C19 steroids in the prostate (2013) (0)
- Session Summary (2004) (0)
- Abstract B23: The anticancer properties of South African herbal teas utilizing an in vitro pre-exposure anti-inflammatory UVB/keratinocyte model (2017) (0)
- A novel method for the preparation of substrate-free cytochrome P-450(11) beta. (1985) (0)
- Subject Index Vol. 1, 1972/73 (1972) (0)
- Modelling Baboon Cytochrome P45011A1 and 11B1 (2006) (0)
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