Amer A. Beg
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Amer A. Beg's AcademicInfluence.com Rankings
Amer A. Begbiology Degrees
Biology
#13641
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#17195
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Cell Biology
#761
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#777
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Genetics
#1527
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#1630
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Molecular Biology
#2328
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#2363
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Biology
Amer A. Beg's Degrees
- PhD Molecular Biology University of California, San Francisco
- Bachelors Biochemistry University of California, Berkeley
Why Is Amer A. Beg Influential?
(Suggest an Edit or Addition)Amer A. Beg's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death (1996) (2984)
- Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB (1995) (1414)
- An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. (1996) (1126)
- Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation (1993) (968)
- The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors. (1993) (765)
- Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. (1995) (746)
- Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity (1991) (729)
- I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention. (1992) (664)
- Influenza A Virus NS1 Protein Prevents Activation of NF-κB and Induction of Alpha/Beta Interferon (2000) (592)
- Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. (2002) (540)
- An Essential Role of the NF-κB/Toll-Like Receptor Pathway in Induction of Inflammatory and Tissue-Repair Gene Expression by Necrotic Cells1 (2001) (490)
- Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice. (1995) (469)
- A mechanism of suppression of TGF–β/SMAD signaling by NF-κB/RelA (2000) (450)
- Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. (2007) (428)
- Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation* (1997) (405)
- Dendritic Cell Development and Survival Require Distinct NF-κB Subunits (2002) (393)
- Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells. (2007) (376)
- NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration (2011) (301)
- Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors. (1994) (300)
- Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment1 (2001) (292)
- Degradation of Promoter-bound p65/RelA Is Essential for the Prompt Termination of the Nuclear Factor κB Response (2004) (280)
- HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma (2016) (225)
- Dendritic cell development and survival require distinct NF-kappaB subunits. (2002) (220)
- Activation of Dendritic Cells via Inhibition of Jak2/STAT3 Signaling1 (2005) (216)
- Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma (2015) (212)
- The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis (2011) (201)
- A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA. (2000) (164)
- A Critical Role for the RelA Subunit of Nuclear Factor κB in Regulation of Multiple Immune-response Genes and in Fas-induced Cell Death (1999) (161)
- Induction of NF-kappa B DNA-binding activity during the G0-to-G1 transition in mouse fibroblasts (1991) (161)
- The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects. (1999) (156)
- PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development (2003) (156)
- Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor κB in Regulating Mature T Cell Survival and In Vivo Function (2003) (150)
- NF-κB RelA Subunit Is Crucial for Early IFN-β Expression and Resistance to RNA Virus Replication (2010) (132)
- Induction of Necrotic-Like Cell Death by Tumor Necrosis Factor Alpha and Caspase Inhibitors: Novel Mechanism for Killing Virus-Infected Cells (2000) (129)
- NF-κB RelA (p65) Is Essential for TNF-α-Induced Fas Expression but Dispensable for Both TCR-Induced Expression and Activation-Induced Cell Death1 (2001) (119)
- Erratum: IKB interacts with the nuclear localization sequences of the subunits of NF-KB: A mechanism for cytoplasmic retention (Genes and Development (1992) 6 (1899-1913)) (1992) (112)
- Cutting Edge: CD28 and c-Rel–Dependent Pathways Initiate Regulatory T Cell Development (2010) (112)
- An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2. (2002) (110)
- NF-κB Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis (2011) (106)
- NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule (1993) (104)
- Distinct Roles of Different NF-κB Subunits in Regulating Inflammatory and T Cell Stimulatory Gene Expression in Dendritic Cells1 (2007) (103)
- Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma. (2009) (100)
- Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells (2013) (94)
- Interferons Direct an Effective Innate Response to Legionella pneumophila Infection* (2009) (86)
- Lung tumor NF-κB signaling promotes T cell-mediated immune surveillance. (2013) (85)
- Distinct Roles for the NF-κB RelA Subunit during Antiviral Innate Immune Responses (2011) (83)
- RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair (2009) (80)
- PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. (2009) (78)
- Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor. (1994) (74)
- Lack of Essential Role of NF-κB p50, RelA, and cRel Subunits in Virus-Induced Type 1 IFN Expression1 (2007) (71)
- Defining Emerging Roles for NF-κB in Antivirus Responses: Revisiting the Interferon-β Enhanceosome Paradigm (2011) (69)
- IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer (2013) (68)
- Phase I/Ib Study of Pembrolizumab Plus Vorinostat in Advanced/Metastatic Non–Small Cell Lung Cancer (2019) (62)
- The Th17 immune response is controlled by a c-Rel-ROR{gamma}-ROR{gamma}T transcriptional axis (2010) (60)
- Proteogenomic landscape of squamous cell lung cancer (2017) (56)
- IκBα/IκBε deficiency reveals that a critical NF-κB dosage is required for lymphocyte survival (2003) (50)
- ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis (2022) (47)
- Bid-Independent Mitochondrial Activation in Tumor Necrosis Factor Alpha-Induced Apoptosis and Liver Injury (2006) (47)
- NF-kappa B RelA (p65) is essential for TNF-alpha-induced fas expression but dispensable for both TCR-induced expression and activation-induced cell death. (2001) (44)
- IKB interacts with the nuclear localization sequences of the subunits of NF-KB: a mechanism for cytoplasmic retention (2007) (44)
- Phosphorylation of p50 NF-κB at a Single Serine Residue by DNA-dependent Protein Kinase Is Critical for VCAM-1 Expression upon TNF Treatment* (2010) (41)
- Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice. (2013) (40)
- Phase I/II study of the A2AR antagonist NIR178 (PBF-509), an oral immunotherapy, in patients (pts) with advanced NSCLC. (2018) (35)
- Regulation of Developing B Cell Survival by RelA-Containing NF-κB Complexes 1 (2003) (34)
- A butterfly flutters by (1995) (33)
- NF-KB plOO (Lyt-10) Is a Component of H2TF1 and Can Function as an IKB-Like Molecule (32)
- Regulation of α-Fetoprotein by Nuclear Factor-κB Protects Hepatocytes from Tumor Necrosis Factor-α Cytotoxicity during Fetal Liver Development and Hepatic Oncogenesis (2004) (30)
- IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival. (2003) (29)
- The RelA(p65) Subunit of NF-κB Is Essential for Inhibiting Double-stranded RNA-induced Cytotoxicity* (2001) (28)
- HDAC inhibitors with PD-1 blockade: a promising strategy for treatment of multiple cancer types? (2016) (22)
- Induction of NF-KB DNA-Binding Activity during the Go-to-G1 Transition in Mouse Fibroblasts (21)
- PKCθ Is Required For Alloreactivity And GVHD But Not For Immune Responses Toward Leukemia And Infection In Mice (2010) (21)
- Regulation of developing B cell survival by RelA-containing NF-kappa B complexes. (2003) (21)
- c‐Rel is an essential transcription factor for the development of acute graft‐versus‐host disease in mice (2013) (20)
- A Sensitive NanoString‐Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma (2016) (19)
- Genetic Delineation of the Pathways Mediated by Bid and JNK in Tumor Necrosis Factor-α-induced Liver Injury in Adult and Embryonic Mice* (2009) (19)
- Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis. (2004) (18)
- ComPPARtmentalizing NF-κB in the gut (2004) (18)
- Differential Requirement for the IKKβ/NF-κB Signaling Module in Regulating TLR- versus RLR-Induced Type 1 IFN Expression in Dendritic Cells (2014) (18)
- Non-canonical IKKs, IKKϵ and TBK1, as novel therapeutic targets in the treatment of non-small cell lung cancer (2013) (18)
- Propelling Immunotherapy Combinations Into the Clinic. (2015) (17)
- Interleukin polymorphisms associated with overall survival, disease‐free survival, and recurrence in non‐small cell lung cancer patients (2015) (16)
- TNFRSF10B polymorphisms and haplotypes associated with increased risk of death in non-small cell lung cancer. (2013) (15)
- Phase I study of taminadenant (PBF509/NIR178), an adenosine 2A receptor antagonist, with or without spartalizumab, in patients with advanced non-small cell lung cancer. (2022) (12)
- Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis (2019) (12)
- TumorNecrosis Factor andInterleukin-1 Leadto Phosphorylation andLossofIKBoL: a Mechanism for NF-idBActivation (1993) (12)
- NF‐κB is crucial in proximal T‐cell signaling for calcium influx and NFAT activation (2014) (10)
- DNA-binding proteins. A butterfly flutters by. (1995) (8)
- Phase I/Ib study of pembrolizumab and vorinostat in patients with metastatic NSCLC (mNSCLC). (2018) (8)
- Phase II randomized trial of first-line pembrolizumab and vorinostat in patients with metastatic NSCLC (mNSCLC). (2020) (7)
- ComPPARtmentalizing NF-kappaB in the gut. (2004) (7)
- NF-kB RelA (p65) Is Essential for TNF-a-Induced Fas Expression but Dispensable for Both TCR-Induced Expression and Activation-Induced Cell Death (2001) (6)
- P1.04-32 Phase I/II Study of the A2AR Antagonist NIR178 (PBF-509), an Oral Immunotherapy, in Patients (pts) with Advanced NSCLC (2018) (5)
- TIMEx: tumor-immune microenvironment deconvolution web-portal for bulk transcriptomics using pan-cancer scRNA-seq signatures (2021) (5)
- A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy (2013) (4)
- Targeting PKCθ in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential (2012) (4)
- MEK inhibition modulates cytokine response to mediate therapeutic efficacy in lung cancer. (2019) (4)
- Utilization of target lesion heterogeneity for treatment efficacy assessment in late stage lung cancer (2021) (3)
- Mistic: An open-source multiplexed image t-SNE viewer (2021) (2)
- Charting Immune Signaling Proteomes En Route to New Therapeutic Strategies (2015) (2)
- Genetic and Pharmacologic Inhibition of PKCθ and PKCα Prevents Acute Gvhd While Sparing GVL Activity in Mice. (2012) (1)
- The Nuclear Factor-κB Transcription Factor Pathway (2009) (1)
- Abstract 4578: Development of MEM-288, a dual-transgene armed and conditionally replication-enhanced oncolytic adenovirus with potent systemic antitumor immunity (2020) (1)
- DevelopmentPathways Initiate Regulatory T Cell Dependent - Cutting Edge: CD28 and c-Rel (2010) (1)
- Abstract 697: Defining anti-tumor immune stimulatory mechanisms of MEM-288, a CD40 ligand and IFN-beta dual-transgene armed oncolytic adenovirus (2021) (1)
- IKKβ‐induced inflammation impacts the kinetics but not the magnitude of the immune response to a viral vector (2012) (1)
- The Control of Cell Energy Metabolism by NF-Kb Transcription Factors: 1934 (2012) (0)
- Abstract 4159: Characterization of three recurring STK11/LKB1 mutants in lung adenocarcinoma (2014) (0)
- Abstract B072: MEK inhibition modulates cytokine response to mediate therapeutic efficacy in lung cancer (2019) (0)
- DevelopmentInitiate Regulatory T Cell Dependent - Cutting Edge: CD28 and c-Rel (2017) (0)
- CRYSTAL STRUCTURE OF THE C713S MUTANT OF THE TIR DOMAIN OF HUMAN TLR2 (2002) (0)
- Abstract 5662: MEK inhibitors potentiate tumor immune surveillance by enhancing cancer cell response of IFNγ (2017) (0)
- NF- (cid:1) B Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis (cid:1) (2011) (0)
- Jak2/STAT3 Signaling Activation of Dendritic Cells via Inhibition of (0)
- Defining a novel role for the NF-κB pathway in proximal TCR signaling. (IRM10P.746) (2014) (0)
- ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis (2022) (0)
- Abstract 1709: Targeting immune checkpoint therapy to the lung tumor microenvironment (2017) (0)
- Abstract 3542: Oncolytic adenovirus encoding transgenes for IFN-beta and recombinant CD40 ligand promotes conventional dendritic cell activation and trafficking with enhanced tumor infiltrating lymphocytes for effective cancer immunotherapy (2022) (0)
- Cereblon, a molecular target of lenalidomide (IMiDs), negatively regulates T cell activation (IRM7P.715) (2015) (0)
- Oncogenic Ha-Ras-induced Signaling Activates NF- (cid:107) B Transcriptional Activity, Which Is Required for Cellular Transformation* (1997) (0)
- Activation-Induced Cell Death Both TCR-Induced Expression and-Induced Fas Expression but Dispensable for α B RelA ( p 65 ) Is Essential for TNF-κ NF-Gerondakis and (2001) (0)
- Abstract B020: Distinct spatiotemporal tumor-immune ecologies enable disease prediction in NSCLC patients (2022) (0)
- The role of PKC-Theta in CD8 T cell activation (B28) (2007) (0)
- Abstract 937: Dissection of KRAS-driven survival signaling networks via phosphoproteomics in lung cancer cells. (2013) (0)
- Abstract 655: Necroptosis promotes tumor growth through IL1-alpha release and recruitment of immunosuppressive myeloid cells (2023) (0)
- NF-kB as a Regulator of FA/BRCA Gene Expression in Multiple Myeloma. (2007) (0)
- Distinct tumor-immune ecologies in NSCLC patients predict progression and define a clinical biomarker of therapy response (2022) (0)
- Abstract CT103: A phase 1 first-in-human study of MEM-288 oncolytic virus in solid tumors including non-small cell lung cancer (NSCLC): impact on tumor and systemic T cell immunity (2023) (0)
- The Th17 immune response is controlled by a c-Rel−RORγ−RORγT transcriptional axis (50.36) (2010) (0)
- Phase I/Ib study of pembrolizumab and vorinostat in patients with metastatic NSCLC (mNSCLC): Updated results. (2019) (0)
- Tumor Necrosis Factor and Interleukin-1 Lead to Phosphorylation and Loss of IKBoL: a Mechanism for NF-idB Activation (2003) (0)
- Effective Prevention of Acute Graft-Verses-Host Disease by Targeting PKC Alpha and PKC Theta in Mice (2011) (0)
- Distinct Roles for the NF- (cid:1) B RelA Subunit during Antiviral Innate Immune Responses (cid:1) † (2011) (0)
- Combination IFNβ and membrane-stable CD40L maximize tumor dendritic cell activation and lymph node trafficking to elicit systemic T-cell immunity. (2023) (0)
- DNA‐DEPENDENT PROTEIN KINASE IS CRITICAL FOR VCAM‐1 EXPRESSION UPON TNF TREATMENT THROUGH PHOSPHORYLATION OF p50 NF‐kappa B: A CRITICAL INVOLVEMENT IN VASCULAR AND LUNG INFLAMMATION (2012) (0)
- Potentiation of T Lymphocyte Responses by Modulating NF - Kappa Beta Activity in Dendritic Cells (2003) (0)
- Targeting PKCtheta Inhibits Alloreactivity and Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia and Anti-Infection Activities. (2009) (0)
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What Schools Are Affiliated With Amer A. Beg?
Amer A. Beg is affiliated with the following schools:
