Amita Sehgal
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Indian biologist
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Amita Sehgalbiology Degrees
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Genetics
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Molecular Biology
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Biology
Amita Sehgal's Degrees
- Masters Biotechnology Delhi University
- Bachelors Biotechnology Delhi University
Why Is Amita Sehgal Influential?
(Suggest an Edit or Addition)According to Wikipedia, Amita Sehgal is a molecular biologist and chronobiologist in the Department of Neuroscience at the Perelman School of Medicine at the University of Pennsylvania. Sehgal was involved in the discovery of Drosophila TIM and many other important components of the Drosophila clock mechanism. Sehgal also played a pivotal role in the development of Drosophila as a model for the study of sleep. Her research continues to be focused on understanding the genetic basis of sleep and also how circadian systems relate to other aspects of physiology.
Amita Sehgal's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Rest in Drosophila Is a Sleep-like State (2000) (839)
- Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. (1994) (606)
- Pharmacological Rescue of Synaptic Plasticity, Courtship Behavior, and Mushroom Body Defects in a Drosophila Model of Fragile X Syndrome (2005) (490)
- Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature A Humoral Mechanism to Reset a Peripheral Clock (2001) (465)
- Sleep in Drosophila is regulated by adult mushroom bodies (2006) (423)
- Regulation of the Drosophila Protein Timeless Suggests a Mechanism for Resetting the Circadian Clock by Light (1996) (409)
- Isolation of timeless by PER Protein Interaction: Defective Interaction Between timeless Protein and Long-Period Mutant PERL (1995) (386)
- Rhythmic Expression of timeless: A Basis for Promoting Circadian Cycles in period Gene Autoregulation (1995) (379)
- Block in nuclear localization of period protein by a second clock mutation, timeless. (1994) (364)
- A Drosophila model for age-associated changes in sleep:wake cycles (2006) (306)
- Identification of SLEEPLESS, a Sleep-Promoting Factor (2008) (282)
- JETLAG Resets the Drosophila Circadian Clock by Promoting Light-Induced Degradation of TIMELESS (2006) (281)
- Posttranslational Regulation of Drosophila PERIOD Protein by Protein Phosphatase 2A (2004) (281)
- A Sleep-Promoting Role for the Drosophila Serotonin Receptor 1A (2006) (279)
- Positional Cloning and Sequence Analysis of the Drosophila Clock Gene, timeless (1995) (278)
- Drosophila Lacking dfmr1 Activity Show Defects in Circadian Output and Fail to Maintain Courtship Interest (2002) (276)
- A role for the proteasome in the light response of the timeless clock protein. (1999) (273)
- Role of Molecular Oscillations in Generating Behavioral Rhythms in Drosophila (2001) (253)
- An Abrupt Shift in the Day/Night Cycle Causes Desynchrony in the Mammalian Circadian Center (2003) (252)
- Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila. (2008) (250)
- Identification of a Neural Circuit that Underlies the Effects of Octopamine on Sleep:Wake Behavior (2010) (246)
- Serotonin Modulates Circadian Entrainment in Drosophila (2005) (245)
- Circadian Rhythms and Sleep in Drosophila melanogaster (2017) (238)
- The Circadian Clock Protein BMAL1 Is Necessary for Fertility and Proper Testosterone Production in Mice (2008) (235)
- A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis (2001) (219)
- Circadian Rhythms, Sleep, and Disorders of Aging (2016) (211)
- Molecular components of the circadian system in Drosophila. (2001) (211)
- Identification of a Circadian Output Circuit for Rest:Activity Rhythms in Drosophila (2014) (188)
- A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia (2010) (184)
- Gender Dimorphism in the Role of cycle (BMAL1) in Rest, Rest Regulation, and Longevity in Drosophila melanogaster (2003) (175)
- Photic Signaling by Cryptochrome in the DrosophilaCircadian System (2001) (174)
- Octopamine Regulates Sleep in Drosophila through Protein Kinase A-Dependent Mechanisms (2008) (171)
- Circadian Control of Eclosion Interaction between a Central and Peripheral Clock in Drosophila melanogaster (2003) (162)
- Genetics of Sleep and Sleep Disorders (2011) (149)
- Guidelines for Genome-Scale Analysis of Biological Rhythms (2017) (146)
- Genetic analysis of sleep. (2010) (145)
- A Critical Period of Sleep for Development of Courtship Circuitry and Behavior in Drosophila (2014) (141)
- The circadian clock interacts with metabolic physiology to influence reproductive fitness. (2011) (140)
- A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux (2018) (138)
- Non-cyclic and Developmental Stage-Specific Expression of Circadian Clock Proteins During Murine Spermatogenesis1 (2003) (135)
- Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1). (2007) (134)
- Response of the Timeless Protein to Light Correlates with Behavioral Entrainment and Suggests a Nonvisual Pathway for Circadian Photoreception (1998) (130)
- Regulation of Circadian Behavioral Output via a MicroRNA-JAK/STAT Circuit (2012) (130)
- AKT and TOR Signaling Set the Pace of the Circadian Pacemaker (2010) (129)
- Ontogeny of a biological clock in Drosophila melanogaster. (1992) (118)
- Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila. (2016) (118)
- The need for a simple animal model to understand sleep (2000) (117)
- The Effects of Caffeine on Sleep in Drosophila Require PKA Activity, But Not the Adenosine Receptor (2009) (117)
- FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress (2007) (116)
- WIDE AWAKE Mediates the Circadian Timing of Sleep Onset (2014) (114)
- SLEEPLESS, a Ly–6/Neurotoxin Family Member, Regulates Levels, Localization, and Activity of Shaker (2009) (109)
- Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt (2015) (108)
- Probing the Relative Importance of Molecular Oscillations in the Circadian Clock (2008) (108)
- Interaction between sleep and the immune response in Drosophila: a role for the NFkappaB relish. (2007) (105)
- A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila. (2008) (102)
- A Drosophila model for Angelman syndrome (2008) (101)
- A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila (2019) (98)
- A Circadian Output in Drosophila Mediated by Neurofibromatosis-1 and Ras/MAPK (2001) (98)
- Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals. (2017) (95)
- Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells (2016) (91)
- The Thymus Is Similar to the Testis in Its Pattern of Circadian Clock Gene Expression (2005) (89)
- Human and rat gut microbiome composition is maintained following sleep restriction (2017) (88)
- Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations (2012) (88)
- Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount (2014) (86)
- Drosophila melanogaster: an insect model for fundamental studies of sleep. (2005) (81)
- Regulation of the Blood–Brain Barrier by Circadian Rhythms and Sleep (2019) (80)
- Ribosome profiling reveals an important role for translational control in circadian gene expression (2015) (79)
- Conserved regions of the timeless (tim) clock gene in Drosophila analyzed through phylogenetic and functional studies. (1998) (76)
- The Drosophila circuitry of sleep–wake regulation (2017) (73)
- A Fly's Eye View of Circadian Entrainment (2003) (71)
- Speed control: cogs and gears that drive the circadian clock (2012) (70)
- New short period mutations of the Drosophila clock gene per (1992) (69)
- Novel Insights into the Regulation of the Timeless Protein (2003) (68)
- Genetic and Anatomical Basis of the Barrier Separating Wakefulness and Anesthetic-Induced Unresponsiveness (2013) (68)
- Insulin Signaling Misregulation underlies Circadian and Cognitive Deficits in a Drosophila Fragile X Model (2016) (67)
- Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila (2004) (66)
- A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity (2017) (66)
- Monoamines and sleep in Drosophila. (2014) (65)
- Interaction between Sleep and Metabolism in Drosophila with Altered Octopamine Signaling* (2012) (65)
- Quantitative Genetic Analysis of Sleep in Drosophila melanogaster (2008) (63)
- Caffeine promotes wakefulness via dopamine signaling in Drosophila (2016) (60)
- Regulation of insect behavior via the insulin-signaling pathway (2013) (58)
- G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment (2019) (57)
- An Isoform-Specific Mutant Reveals a Role of PDP1ε in the Circadian Oscillator (2009) (56)
- Cooperative Interaction between Phosphorylation Sites on PERIOD Maintains Circadian Period in Drosophila (2013) (56)
- Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. (2008) (53)
- Sleep deprivation suppresses aggression in Drosophila (2015) (52)
- Drosophila TIM Binds Importin α1, and Acts as an Adapter to Transport PER to the Nucleus (2015) (52)
- Why a fly? Using Drosophila to understand the genetics of circadian rhythms and sleep. (2004) (52)
- Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue (2016) (52)
- Molecular biology of circadian rhythms (2004) (50)
- Dopamine acts through Cryptochrome to promote acute arousal in Drosophila. (2012) (49)
- Endocytosis at the Drosophila blood–brain barrier as a function for sleep (2018) (48)
- A neuron-glia interaction involving GABA Transaminase contributes to sleep loss in sleepless mutants (2014) (47)
- Context-specific comparison of sleep acquisition systems in Drosophila (2015) (46)
- Regulation of the cycling of timeless (tim) RNA. (2001) (46)
- Oscillation and Light Induction of timeless mRNA in the Mammalian Circadian Clock (1999) (45)
- An ecdysone-responsive nuclear receptor regulates circadian rhythms in Drosophila (2014) (44)
- Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain (2018) (44)
- Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System. (2020) (43)
- Control of Circadian Rhythms by a Two-Component Clock (1996) (42)
- Physiology Flies with Time (2017) (41)
- Alterations of per RNA in Noncoding Regions Affect Periodicity of Circadian Behavioral Rhythms (1998) (36)
- Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs (2013) (34)
- Small-Molecule Screen in Adult Drosophila Identifies VMAT as a Regulator of Sleep (2013) (34)
- A Conserved Circadian Function for the Neurofibromatosis 1 Gene (2018) (34)
- KPNB1 mediates PER/CRY nuclear translocation and circadian clock function (2015) (34)
- Availability of food determines the need for sleep in memory consolidation (2020) (33)
- A circadian clock regulates efflux by the blood-brain barrier in mice and human cells (2021) (33)
- Drosophila Nipped-B Mutants Model Cornelia de Lange Syndrome in Growth and Behavior (2015) (33)
- 19 Circadian Rhythms and Sleep (2007) (33)
- The Drosophila Circadian Clock Gates Sleep through Time-of-Day Dependent Modulation of Sleep-Promoting Neurons. (2016) (32)
- The Central Clock Neurons Regulate Lipid Storage in Drosophila (2011) (31)
- Molecular analysis of sleep: wake cycles in Drosophila. (2007) (30)
- Changes in Female Drosophila Sleep following Mating Are Mediated by SPSN-SAG Neurons (2016) (29)
- Effect of taurine and caffeine on sleep–wake activity in Drosophila melanogaster (2010) (27)
- Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis* (2015) (26)
- Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle (2021) (26)
- Restoration of circadian behavioural rhythms in a period null Drosophila mutant (per01) by mammalian period homologues mPer1 and mPer2 (2002) (25)
- Altered ocular parameters from circadian clock gene disruptions (2019) (25)
- Signaling components that drive circadian rhythms (2002) (24)
- Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila (2018) (23)
- Circadian and Sleep Metabolomics Across Species. (2020) (23)
- Genetic dissection of the circadian clock: A timeless story (1995) (23)
- Genetic Dissociation of Daily Sleep and Sleep Following Thermogenetic Sleep Deprivation in Drosophila. (2016) (23)
- Drosophila QVR/SSS Modulates the Activation and C-Type Inactivation Kinetics of Shaker K+ Channels (2011) (23)
- Altered Entrainment and Feedback Loop Function Effected by a Mutant Period Protein (2000) (22)
- Circadian rhythms: Finer clock control (2002) (22)
- Circadian Rhythms, Disease and Chronotherapy (2021) (22)
- Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep (2015) (21)
- Circadian- and Light-driven Metabolic Rhythms in Drosophila melanogaster (2018) (20)
- Molecular Biology of Circadian Rhythms: Sehgal/Circadian Rhythms (2005) (20)
- Post-Translational Regulation and Nuclear Entry of TIMELESS and PERIOD Are Affected in New timeless Mutant (2011) (20)
- The Glial Perspective on Sleep and Circadian Rhythms. (2020) (19)
- The NRON complex controls circadian clock function through regulated PER and CRY nuclear translocation (2019) (19)
- Energy Stores Are Not Altered by Long-Term Partial Sleep Deprivation in Drosophila melanogaster (2009) (18)
- Wolbachia affects sleep behavior in Drosophila melanogaster. (2018) (17)
- Day–night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis (2014) (16)
- Casein Kinase 1 Promotes Synchrony of the Circadian Clock Network (2014) (16)
- Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain (2020) (16)
- Heating and cooling the Drosophila melanogaster clock. (2015) (15)
- Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 ( PP 1 ) (2007) (15)
- AANAT1 functions in astrocytes to regulate sleep homeostasis (2019) (14)
- Molecular genetic analysis of circadian rhythms in vertebrates and invertebrates (1995) (13)
- Book Review: Molecular Regulation of Circadian Rhythms in Drosophila and Mammals (2001) (13)
- Natural Populations of Drosophila melanogaster Reveal Features of an Uncharacterized Circadian Property (2014) (12)
- Asymmetric vasopressin signaling spatially organizes the master circadian clock (2018) (12)
- Splicing the Clock to Maintain and Entrain Circadian Rhythms (2019) (12)
- Ac-ing the Clock (2008) (11)
- Short and long sleeping mutants reveal links between sleep and macroautophagy (2021) (11)
- What makes the circadian clock tick: genes that keep time? (1999) (10)
- Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates (2021) (10)
- Molecular control of Drosophila circadian rhythms (2001) (8)
- Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster (2020) (8)
- Aneuploidy in drosophila. III: Aneuploidogens inhibit in vitro assembly of taxol‐purified drosophila microtubules (1990) (8)
- Circadian Rhythms and Disease (2019) (8)
- Manipulations of the olfactory circuit highlight the role of sensory stimulation in regulating sleep amount. (2020) (6)
- Circadian rhythms and biological clocks (2015) (5)
- New perspectives on circadian rhythms and sleep (2013) (5)
- Temperature oscillations drive cycles in the activity of MMP-2,9 secreted by a human trabecular meshwork cell line. (2015) (4)
- Cold Temperatures Fire up Circadian Neurons. (2018) (4)
- Control of Metabolism by Central and Peripheral Clocks in Drosophila (2016) (4)
- REV-ving up the clock. (2002) (4)
- Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism (2019) (4)
- RNA Splicing Factor Mutations That Cause Retinitis Pigmentosa Result in Circadian Dysregulation (2019) (3)
- Genetic Mechanisms Underlying Sleep. (2019) (3)
- Circadian and Sleep Circuits Ring Together (2018) (2)
- Ecdysone acts through cortex glia to regulate sleep in Drosophila (2022) (2)
- Methods in Enzymology. Circadian rhythms and biological clocks, part B. Preface. (2015) (2)
- Hugin+ neurons link the sleep homeostat to circadian clock neurons (2020) (2)
- Methods in Enzymology. Circadian rhythms and biological clocks, part A. Preface. (2015) (2)
- Hugin+ neurons provide a link between sleep homeostat and circadian clock neurons (2021) (2)
- Author response: Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue (2016) (2)
- The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development. (2020) (1)
- Polyamine elevation and nitrogen stress are toxic hallmarks of chronic sleep loss in Drosophila melanogaster (2021) (1)
- Consolidation of Sleep-Dependent Appetitive Memory Is Mediated by a Sweet-Sensing Circuit (2022) (1)
- A Circuit Mechanism Underlying Suppression of Circadian Signals by Homeostatic Sleep Drive (2020) (1)
- Cellular and molecular analysis of sleep in Drosophila (2007) (1)
- Supplemental Data Pharmacological Rescue of Synaptic Plasticity , Courtship Behavior , and Mushroom Body Defects in a Drosophila Model of Fragile X Syndrome (2005) (1)
- The 2020 Pittendrigh/Aschoff Lecture: My Circadian Journey (2021) (1)
- Molecular Components of a Model Circadian Clock: Lessons from Drosophila (1998) (1)
- Meeting Report: The Allied Genetics Conference 2016 (2016) (1)
- Couples for couples: co-therapy as interpretive action (2020) (1)
- New Routes for Memory Retrieval and Reinforcement (2009) (1)
- Circadian regulation of lung repair and regeneration (2021) (1)
- Modulation of sleep by trafficking of lipids through the Drosophila blood brain barrier (2022) (1)
- Flies come through again, period (2018) (1)
- Tumors set time (2016) (1)
- The microbiome stabilizes circadian rhythms in the gut (2023) (1)
- Circadian Control of Pulmonary Endothelial Signaling occurs via the NADPH oxidase 2-NLRP3 pathway (2022) (1)
- Genetic and Molecular Approaches Used to Analyze Rhythms (2005) (1)
- Control of Rest–Activity Behavior by the Central Clock in Drosophila (2015) (1)
- Author response: KPNB1 mediates PER/CRY nuclear translocation and circadian clock function (2015) (0)
- Availability of food determines the need for sleep in memory consolidation (2020) (0)
- Monitoring Electrical Activity in Drosophila Circadian Output Neurons. (2021) (0)
- Author response: Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount (2013) (0)
- Author response: Sleep deprivation suppresses aggression in Drosophila (2015) (0)
- Physiological Temperature Oscillations Alter Matrix Metalloproteinase MMP-2,9 Secretion by TM5 Human Trabecular Meshwork Cells Independent of Clock Genes Per2 and Cry2 (2014) (0)
- Entrainment of the Drosophila circadian clock by light (2002) (0)
- Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (2023) (0)
- Author response: Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates (2021) (0)
- Author response: Short and long sleeping mutants reveal links between sleep and macroautophagy (2021) (0)
- Molecular Analysis of Circadian Rhythms in Neurospora (2005) (0)
- Author response: Endocytosis at the Drosophila blood–brain barrier as a function for sleep (2018) (0)
- Protein Phosphatases and Circadian Clocks (2010) (0)
- Inflammation induced disruption in Circadian Rhythm in Pulmonary Endothelial Cells is modulated via Reactive Oxygen Species (2019) (0)
- OctopamineRegulatesSleepinDrosophilathroughProtein KinaseA-DependentMechanisms (2008) (0)
- Molecular and cellular circuits underlying circadian rhythms of behavior (2013) (0)
- A protein called RYE has a central role in the regulation of sleep. (2014) (0)
- Efficient Processing andExpression ofHumanNerveGrowthFactor Receptors inXenopuslaevis Oocytes: Effects onMaturation (1988) (0)
- Variant-to-gene, gene-to-trait: finding new sleep genes through GWAS. (2023) (0)
- Circadian Rhythms, Sleep, and Aging: New Visions on the Clock, Sleep, and Aging (2020) (0)
- Molecular and Cellular Networks That Drive Sleep (2020) (0)
- A circadian clock in the blood-brain barrier regulates xenobiotic efflux from the brain (2017) (0)
- Drosophila Myc is Involved in Fly Circadian Behavior (P1.112) (2018) (0)
- Loss of Circadian Protection in Adults Exposed to Neonatal Hyperoxia (2020) (0)
- The Kinetics and (Dys)kinetics of Cancer Chronotherapy. (2022) (0)
- Chronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress (2023) (0)
- Author response: Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila (2018) (0)
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