Amy Andreotti
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American biochemist
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Amy Andreottibiology Degrees
Biology
#14237
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#17943
Historical Rank
Biochemistry
#2696
World Rank
#2879
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Biology
Amy Andreotti's Degrees
- Bachelors Biochemistry University of California, Berkeley
- PhD Biochemistry Stanford University
Why Is Amy Andreotti Influential?
(Suggest an Edit or Addition)According to Wikipedia, Amy Hamilton Andreotti is an American biochemist who is the Roy J. Carver Chair and University Professor of Biochemistry, Biophysics, and Molecular Biology at Iowa State University. Her research considers TEC kinases including Bruton's Tyrosine Kinase and IL-2 Inducible T-cell Kinase .
Amy Andreotti's Published Works
Published Works
- T-cell signaling regulated by the Tec family kinase, Itk. (2010) (494)
- Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR. (1993) (328)
- Regulatory intramolecular association in a tyrosine kinase of the Tec family (1997) (275)
- Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A (2002) (257)
- Native state proline isomerization: an intrinsic molecular switch. (2003) (236)
- Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. (2004) (203)
- Structural characterization of a proline-driven conformational switch within the Itk SH2 domain (2002) (116)
- Positive Regulation of Itk PH Domain Function by Soluble IP4 (2007) (101)
- In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell Kinase (2012) (95)
- The effects of glycosylation on peptide backbone conformation (1993) (94)
- Solution and micelle-bound structures of tachyplesin I and its active aromatic linear derivatives. (2002) (93)
- A specific intermolecular association between the regulatory domains of a Tec family kinase. (2000) (85)
- The linker between SH2 and kinase domains positively regulates catalysis of the Tec family kinases. (2007) (56)
- Bacterial expression and purification of interleukin-2 tyrosine kinase: single step separation of the chaperonin impurity. (2008) (55)
- A remote substrate docking mechanism for the tec family tyrosine kinases. (2007) (47)
- Competing modes of self‐association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization (2002) (45)
- SENSITIVITY OF GLYCOPEPTIDE CONFORMATION TO CARBOHYDRATE CHAIN LENGTH (1995) (44)
- Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain. (2009) (41)
- Molecular details of Itk activation by prolyl isomerization and phospholigand binding: the NMR structure of the Itk SH2 domain bound to a phosphopeptide. (2006) (41)
- Ligand specificity modulated by prolyl imide bond Cis/Trans isomerization in the Itk SH2 domain: a quantitative NMR study. (2003) (39)
- Identification of an allosteric signaling network within Tec family kinases. (2010) (37)
- Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts. (2017) (35)
- Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases (2016) (35)
- Determinants of intra versus intermolecular self-association within the regulatory domains of Rlk and Itk. (2003) (34)
- Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCγ1 (2009) (34)
- Mechanism and functional significance of Itk autophosphorylation. (2007) (33)
- A case study of proline isomerization in cell signaling. (2005) (32)
- NMR characterization of calicheamicin γ1I bound to DNA (1994) (31)
- T Cell Specific Adapter Protein (TSAd) Interacts with Tec Kinase ITK to Promote CXCL12 Induced Migration of Human and Murine T Cells (2010) (29)
- Activation Loop Dynamics Determine the Different Catalytic Efficiencies of B Cell– and T Cell–Specific Tec Kinases (2013) (28)
- Defining a Two-pronged Structural Model for PB1 (Phox/Bem1p) Domain Interaction in Plant Auxin Responses* (2015) (26)
- Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response. (2018) (23)
- Conformational snapshots of Tec kinases during signaling (2009) (23)
- Calmodulin and PI(3,4,5)P3 cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production (2014) (21)
- SH2-dependent autophosphorylation within the Tec family kinase Itk. (2009) (18)
- Substrate recognition of PLCγ1 via a specific docking surface on Itk. (2013) (17)
- Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation. (2015) (17)
- Dynamic regulatory features of the protein tyrosine kinases. (2019) (16)
- An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition. (2017) (15)
- Disrupting the Intermolecular Self-Association of Itk Enhances T Cell Signaling (2010) (15)
- Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue. (2011) (15)
- Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec (2012) (14)
- Solubility of recombinant Src homology 2 domains expressed in E. coli can be predicted by TANGO (2014) (13)
- Opening the pore hinges on proline (2006) (13)
- A Selective NMR Probe to Monitor the Conformational Transition from Inactive to Active Kinase (2014) (12)
- Differential impact of BTK active site inhibitors on the conformational state of full-length BTK (2020) (12)
- Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases (2019) (11)
- Calicheamicin−DNA Recognition: An Analysis of Seven Different Drug−DNA Complexes (2000) (11)
- A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase. (2014) (11)
- Role of Reversible Histidine Coordination in Hydroxylamine Reduction by Plant Hemoglobins (Phytoglobins). (2016) (10)
- Murine Itk SH3 domain (2008) (9)
- Electron self-exchange in hemoglobins revealed by deutero-hemin substitution. (2015) (8)
- Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures. (2012) (7)
- The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell–specific adapter protein (2019) (6)
- Dynamics of the Tec‐family tyrosine kinase SH3 domains (2016) (5)
- Conformational switches that control the TEC kinase – PLCγ signaling axis (2022) (4)
- Solution structure and backbone dynamics of Calsensin, an invertebrate neuronal calcium‐binding protein (2005) (3)
- Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK (2021) (2)
- The conformational state of the BTK substrate PLCγ contributes to Ibrutinib resistance. (2021) (2)
- Mapping the Ca2+ -dependent binding of an invertebrate homolog of protein phosphatase 4 regulatory subunit 2 to the small EF-hand protein, calsensin. (2006) (2)
- PLOS Biology 2016 Reviewer and Editorial Board Thank You (2017) (1)
- The HIV-1 protein Nef activates the Tec family kinase Btk by stabilizing an intermolecular SH3-SH2 domain interaction (2022) (1)
- Purification, crystallization and preliminary crystallographic analysis of the SH2 domain of IL-2-inducible T-cell kinase. (2011) (1)
- Editorial: Targeting Bruton Tyrosine Kinase (2022) (1)
- Using High Order Coevolution Correlations to Identify Sites for Compensating Mutations to Rescue Function (2020) (0)
- NMR structure of Calsensin, energy minimized average structure. (2005) (0)
- The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide (2006) (0)
- NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure (2002) (0)
- Backbone and 1H assignments for Tachyplesin I, wild type (2002) (0)
- Editor's evaluation: Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions (2021) (0)
- Calmodulin boosts Itk activity to induce sustained calcium responses in T cells (P1117) (2013) (0)
- Txk SH3 domain backbone assignments (2003) (0)
- Tachyplesin I solution structure in the presence of 300mM Dodecylphosphocholine micelles (2002) (0)
- SignalingSelf-Association of Itk Enhances T Cell Disrupting the Intermolecular (2010) (0)
- Solution Structure of Tachyplesin I Mutant TPY4 in water (2002) (0)
- Decision letter: AKAP79 enables calcineurin to directly suppress protein kinase A activity (2021) (0)
- An autoinhibitory role for the Pleckstrin Homology domain of ITK and its interplay with canonical phospholipid recognition (2018) (0)
- Targeting of ITK-SYK fusion oncogene through in-silico generated and biologically validated ITK-PH domain modulators (2020) (0)
- Abstract 1870: Screening and characterization of allosteric small molecules that target Bruton’s Tyrosine Kinase (2023) (0)
- NMR structure of Calsensin, 20 low energy structures. (2005) (0)
- TPY4 Tachyplesin I tyrosine mutant in the presence of dodecylphosphocholine micelles (300 mM) (2002) (0)
- Defining a Two-Pronged Structural Model for PB1 Domain Interaction in Plant Auxin Responses* (2015) (0)
- Tachyplesin I Wild type peptide NMR Structure (2002) (0)
- NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures (2002) (0)
- Crystal structure of the Itk SH2 domain. (2012) (0)
- The NMR ensemble structure of the Itk SH2 domain bound to a phosphopeptide (2006) (0)
- INTRAMOLECULAR ITK-PROLINE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE (1998) (0)
- Solution Structure of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase (2009) (0)
- Backbone and 1H assignments for Tachyplesin I, phenylalanine mutant (2002) (0)
- Decision letter: Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors (2021) (0)
- Abstract 2024: Employing Solution NMR to Study BTK Activation Through Sortase-Mediated Ligation and Paramagnetic Relaxation Enhancement (2023) (0)
- Backbone and 1H assignments for Tachyplesin I, tyrosine mutant (2002) (0)
- In-silico based screening system to develop allosteric modulators of Bruton’s tyrosine kinase (2020) (0)
- Author response: Differential impact of BTK active site inhibitors on the conformational state of full-length BTK (2020) (0)
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