Amy Hauck Newman
#118,886
Most Influential Person Now
American medicinal chemist
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Amy Hauck Newmanchemistry Degrees
Chemistry
#5107
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#6226
Historical Rank
#946
USA Rank
Organic Chemistry
#886
World Rank
#992
Historical Rank
#128
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Chemistry
Amy Hauck Newman's Degrees
- PhD Medicinal Chemistry University of California, San Francisco
- Bachelors Chemistry University of California, Berkeley
Why Is Amy Hauck Newman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Amy Hauck Newman is an American medicinal chemist who is the scientific director of the intramural research program at the National Institute on Drug Abuse. She researches the design, synthesis, and evaluation of central nervous system active agents as potential treatment medications for substance use disorders, with an emphasis on selective ligands for the dopaminergic system.
Amy Hauck Newman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist (2010) (1082)
- The binding sites for cocaine and dopamine in the dopamine transporter overlap (2008) (327)
- Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. (2010) (313)
- Current perspectives on selective dopamine D3 receptor antagonists as pharmacotherapeutics for addictions and related disorders (2010) (259)
- Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. (2006) (221)
- Tyr-95 and Ile-172 in Transmembrane Segments 1 and 3 of Human Serotonin Transporters Interact to Establish High Affinity Recognition of Antidepressants* (2006) (167)
- Molecular determinants of selectivity and efficacy at the dopamine D3 receptor. (2012) (151)
- The Novel Dopamine D3 Receptor Antagonist NGB 2904 Inhibits Cocaine's Rewarding Effects and Cocaine-Induced Reinstatement of Drug-Seeking Behavior in Rats (2006) (150)
- Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents. (2005) (149)
- Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior (2005) (141)
- Acute administration of SB‐277011A, NGB 2904, or BP 897 inhibits cocaine cue‐induced reinstatement of drug‐seeking behavior in rats: Role of dopamine D3 receptors (2005) (137)
- Medication discovery for addiction: translating the dopamine D3 receptor hypothesis. (2012) (133)
- The N Terminus of Monoamine Transporters Is a Lever Required for the Action of Amphetamines* (2010) (128)
- Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors (2008) (122)
- Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists (2007) (121)
- Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor. (2005) (118)
- The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders (2013) (115)
- Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. (2014) (115)
- R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant Abuse (2012) (109)
- Visualization of Dopamine Transporter Trafficking in Live Neurons by Use of Fluorescent Cocaine Analogs (2009) (108)
- Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand. (1987) (106)
- Identification of a Dopamine Transporter Ligand That Blocks the Stimulant Effects of Cocaine (2005) (104)
- σ Receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain (1988) (101)
- Assessment of Reinforcing Effects of Benztropine Analogs and Their Effects on Cocaine Self-Administration in Rats: Comparisons with Monoamine Uptake Inhibitors (2009) (95)
- Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles. (1994) (93)
- Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents. (2007) (90)
- Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter. (1997) (90)
- Effects of selective dopaminergic compounds on a delay-discounting task (2011) (88)
- What Can Crystal Structures of Aminergic Receptors Tell Us about Designing Subtype-Selective Ligands? (2015) (87)
- Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors. (1995) (87)
- Novel 3alpha-diphenylmethoxytropane analogs: selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine. (1999) (85)
- Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. (2008) (81)
- Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis (2015) (81)
- N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists. (2009) (80)
- Probes for the dopamine transporter: New leads toward a cocaine‐abuse therapeutic—A focus on analogues of benztropine and rimcazole (2002) (79)
- Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter* (2012) (76)
- Effects of N-Substituted Analogs of Benztropine: Diminished Cocaine-Like Effects in Dopamine Transporter Ligands (2004) (73)
- N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity. (2011) (69)
- The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats (2008) (67)
- PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy (1992) (67)
- Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and σ Receptors (2011) (67)
- Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype. (2001) (67)
- Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists. (2007) (66)
- Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters (2001) (63)
- Differential Binding of Tropane-Based Photoaffinity Ligands on the Dopamine Transporter (1999) (62)
- Postendocytic Sorting of Constitutively Internalized Dopamine Transporter in Cell Lines and Dopaminergic Neurons* (2010) (62)
- PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats (2011) (60)
- Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists. (2007) (60)
- Effects of Two Novel D3-Selective Compounds, NGB 2904 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rhesus M (2007) (60)
- The binding sites for benztropines and dopamine in the dopamine transporter overlap (2011) (60)
- Probing Binding Pocket of Serotonin Transporter by Single Molecular Force Spectroscopy on Living Cells* (2011) (59)
- Evidence for Noncanonical Neurotransmitter Activation: Norepinephrine as a Dopamine D2-Like Receptor Agonist (2016) (59)
- Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. (2016) (58)
- Stereospecific reversal of nitrous oxide analgesia by naloxone. (1989) (57)
- 2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors. (2000) (57)
- Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors. (2009) (56)
- Dopamine D3 and D2 Receptor Mechanisms in the Abuse-Related Behavioral Effects of Cocaine: Studies with Preferential Antagonists in Squirrel Monkeys (2010) (56)
- Dopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects (2018) (55)
- N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists. (2003) (54)
- Food Restriction Alters N′-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (Pramipexole)-Induced Yawning, Hypothermia, and Locomotor Activity in Rats: Evidence for Sensitization of Dopamine D2 Receptor-Mediated Effects (2008) (53)
- The novel dopamine D3 receptor antagonists/partial agonists CAB2-015 and BAK4-54 inhibit oxycodone-taking and oxycodone-seeking behavior in rats (2017) (52)
- Effects of Muscarinic M1 Receptor Blockade on Cocaine-Induced Elevations of Brain Dopamine Levels and Locomotor Behavior in Rats (2007) (52)
- Single Molecule Analysis Reveals Coexistence of Stable Serotonin Transporter Monomers and Oligomers in the Live Cell Plasma Membrane* (2014) (52)
- Evaluation of the Blood-Brain Barrier Transport, Population Pharmacokinetics, and Brain Distribution of Benztropine Analogs and Cocaine Using in Vitro and in Vivo Techniques (2003) (51)
- Neuroprotection (focal ischemia) and neurotoxicity (electroencephalographic) studies in rats with AHN649, a 3-amino analog of dextromethorphan and low-affinity N-methyl-D-aspartate antagonist. (1999) (51)
- A Single Glycine in Extracellular Loop 1 Is the Critical Determinant for Pharmacological Specificity of Dopamine D2 and D3 Receptors (2013) (50)
- Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane (2016) (49)
- Combinations of Cocaine with Other Dopamine Uptake Inhibitors: Assessment of Additivity (2009) (49)
- Regional Brain Measurement of Bmax and KD with the Opiate Antagonist Cyclofoxy: Equilibrium Studies in the Conscious Rat (1991) (49)
- Effects of 4′-Chloro-3α-(diphenylmethoxy)-tropane on Mesostriatal, Mesocortical, and Mesolimbic Dopamine Transmission: Comparison with Effects of Cocaine (2005) (46)
- Recognition of Benztropine by the Dopamine Transporter (DAT) Differs from That of the Classical Dopamine Uptake Inhibitors Cocaine, Methylphenidate, and Mazindol as a Function of a DAT Transmembrane 1 Aspartic Acid Residue (2005) (46)
- SARs at the Monoamine Transporters for a Novel Series of Modafinil Analogues (2011) (45)
- Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays (2018) (45)
- Relationship between in Vivo Occupancy at the Dopamine Transporter and Behavioral Effects of Cocaine, GBR 12909 [1-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and Benztropine Analogs (2005) (44)
- Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists. (2009) (43)
- High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice (2015) (43)
- The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion (2007) (43)
- Evaluation of the D3 dopamine receptor selective antagonist PG01037 on l-dopa-dependent abnormal involuntary movements in rats (2009) (43)
- A role for dopamine D1-like receptors in acute food deprivation-induced reinstatement of heroin seeking in rats. (2009) (43)
- The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity (2008) (43)
- Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine (2019) (42)
- Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters (2016) (42)
- Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats (2010) (41)
- Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter. (2005) (41)
- Proerectile Effects of Dopamine D2-Like Agonists Are Mediated by the D3 Receptor in Rats and Mice (2009) (41)
- Dopamine D3 Receptor Partial Agonists and Antagonists as Potential Drug Abuse Therapeutic Agents (2005) (41)
- The highly selective dopamine D 3 R antagonist, R-VK4-40 attenuates oxycodone reward and augments analgesia in rodents (2019) (41)
- Dopamine D2 receptor activation increases vesicular dopamine uptake and redistributes vesicular monoamine transporter-2 protein. (2004) (40)
- Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor. (2017) (40)
- Inhibition of substrate oxidation in mitochondria by the peripheral-type benzodiazepine receptor ligand AHN 086. (1991) (39)
- Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design. (2014) (38)
- Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R). (2017) (38)
- A novel mGluR5 antagonist, MFZ 10‐7, inhibits cocaine‐taking and cocaine‐seeking behavior in rats (2014) (38)
- Tranylcypromine Substituted cis-Hydroxycyclobutylnaphthamides as Potent and Selective Dopamine D3 Receptor Antagonists (2014) (38)
- Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues. (1999) (38)
- Elucidation of Structural Elements for Selectivity across Monoamine Transporters: Novel 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues (2014) (37)
- Behavioral effects of rimcazole analogues alone and in combination with cocaine. (2003) (37)
- Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. (2010) (37)
- N-Substituted Benztropine Analogs: Selective Dopamine Transporter Ligands with a Fast Onset of Action and Minimal Cocaine-Like Behavioral Effects (2011) (36)
- 2016 Philip S. Portoghese Medicinal Chemistry Lectureship: Designing Bivalent or Bitopic Molecules for G-protein Coupled Receptors - The Whole is Greater Than the Sum of its Parts. (2019) (36)
- Cocaine and several σ receptor ligands inhibit dopamine uptake in rat caudate-putamen (1993) (36)
- Effects of buspirone and the dopamine D3 receptor compound PG619 on cocaine and methamphetamine self-administration in rhesus monkeys using a food-drug choice paradigm (2015) (36)
- Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors. (2016) (36)
- Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism. (2017) (35)
- Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. (2007) (35)
- Relations Between Heterogeneity of Dopamine Transporter Binding and Function and the Behavioral Pharmacology of Cocaine (1997) (34)
- Novel tropane-based irreversible ligands for the dopamine transporter. (2001) (34)
- Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans (2013) (34)
- Highly selective chiral N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues for the dopamine transporter: synthesis and comparative molecular field analysis. (2000) (33)
- Influence of body weight and type of chow on the sensitivity of rats to the behavioral effects of the direct-acting dopamine-receptor agonist quinpirole (2011) (33)
- Place Conditioning and Locomotor Effects of N-Substituted, 4′,4′′-Difluorobenztropine Analogs in Rats (2005) (32)
- Novel and Potent Dopamine D2 Receptor Go-Protein Biased Agonists (2019) (32)
- Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation. (2004) (32)
- 3‘-Chloro-3α-(diphenylmethoxy)tropane But Not 4‘-Chloro-3α- (diphenylmethoxy)tropane Produces a Cocaine-like Behavioral Profile† (1997) (31)
- Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog. (1993) (31)
- Cocaine self-administration in dopamine D₃ receptor knockout mice. (2012) (31)
- Dopamine Transporter-Dependent and -Independent Striatal Binding of the Benztropine Analog JHW 007, a Cocaine Antagonist with Low Abuse Liability (2010) (31)
- Labeling of Dopamine Transporter Transmembrane Domain 1 with the Tropane Ligand N-[4-(4-Azido-3-[125I]iodophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane Implicates Proximity of Cocaine and Substrate Active Sites (2008) (30)
- The cocaine-like behavioral effects of meperidine are mediated by activity at the dopamine transporter. (1996) (29)
- Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity (2016) (29)
- Novel anticonvulsant analogs of dextromethorphan: improved efficacy, potency, duration and side-effect profile. (1994) (29)
- Dopamine D3 Receptors Mediate the Discriminative Stimulus Effects of Quinpirole in Free-Feeding Rats (2010) (29)
- Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonists (2010) (29)
- Pharmacodynamic Assessment of the Benztropine Analogues AHN-1055 and AHN-2005 Using Intracerebral Microdialysis to Evaluate Brain Dopamine Levels and Pharmacokinetic/Pharmacodynamic Modeling (2005) (28)
- Behavioral and neurochemical effects of the dopamine transporter ligand 4-chlorobenztropine alone and in combination with cocaine in vivo. (1999) (28)
- Assessment of the Influence of Histaminergic Actions on Cocaine-Like Effects of 3α-Diphenylmethoxytropane Analogs (2005) (27)
- Effects of pramipexole on the reinforcing effectiveness of stimuli that were previously paired with cocaine reinforcement in rats (2011) (27)
- The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys (2009) (26)
- Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodo- (1992) (26)
- New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders. (2021) (25)
- Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. (2006) (25)
- Structure−Activity Relationship Comparison of ( S )-2β-Substituted 3α-(Bis[4-fluorophenyl]methoxy)tropanes and ( R )-2β-Substituted 3β-(3,4-Dichlorophenyl)tropanes at the Dopamine Transporter (2003) (25)
- The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic (2017) (24)
- Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol. (2008) (24)
- Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists (2015) (24)
- Differential effects of the dopamine D3 receptor antagonist PG01037 on cocaine and methamphetamine self-administration in rhesus monkeys (2015) (24)
- CoMFA study of novel phenyl ring-substituted 3alpha-(diphenylmethoxy)tropane analogues at the dopamine transporter. (1999) (24)
- Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands. (2015) (24)
- Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors. (2002) (24)
- The unique psychostimulant profile of (±)‐modafinil: investigation of behavioral and neurochemical effects in mice (2017) (24)
- Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites. (2016) (24)
- Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands. (1994) (23)
- Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter. (1997) (23)
- [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland (1989) (23)
- Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents. (1992) (23)
- 2-Isoxazol-3-Phenyltropane Derivatives of Cocaine: Molecular and Atypical System Effects at the Dopamine Transporter (2014) (23)
- Characterization of the Transport, Metabolism, and Pharmacokinetics of the Dopamine D3 Receptor-Selective Fluorenyl- and 2-Pyridylphenyl Amides Developed for Treatment of Psychostimulant Abuse (2010) (23)
- Novel irreversible ligands specific for "peripheral" type benzodiazepine receptors: (+/-)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-N- (2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlorophenyl )-2H-1,4-benzodiazepin-2-one. (1987) (23)
- Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites. (2013) (22)
- AHN 086: an irreversible ligand of "peripheral" benzodiazepine receptors. (1986) (22)
- Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. (2003) (22)
- Investigation of novel primary and secondary pharmacophores, and 3-substitution in the linking chain of a series of highly selective and bitopic dopamine D3 receptor antagonists and partial agonists. (2019) (22)
- Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues. (2010) (22)
- Novel pharmacotherapies for cocaine abuse 1997 - 2000 (2000) (21)
- Dopamine D3 receptor-based medication development for the treatment of opioid use disorder: Rationale, progress, and challenges (2020) (20)
- Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter. (2002) (20)
- Computational and Biochemical Docking of the Irreversible Cocaine Analog RTI 82 Directly Demonstrates Ligand Positioning in the Dopamine Transporter Central Substrate-binding Site* (2014) (20)
- Interaction of enantiomeric pairs of opiates with phencyclidine binding sites in rat brain: Identification of (+) pentazocine as a ligand potentially suitable for imaging sigma binding sites using positron emission tomography (1988) (20)
- The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D3 Receptor (D3R) Selective Agonists. (2019) (20)
- (+/-)-(N-alkylamino)benzazepine analogs: novel dopamine D1 receptor antagonists. (1995) (20)
- Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats (2020) (20)
- The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration (2013) (19)
- Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D3 Receptor Activation in Male and Female Monkeys (2014) (19)
- Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on l-dopa dependent animal involuntary movements in rats (2011) (19)
- Kinetic analysis of the opiate antagonist cyclofoxy in rat brain: simultaneous infusion of active and inactive enantiomers. (1990) (19)
- Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change (2013) (18)
- How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers (2019) (18)
- Influence of Cocaine History on the Behavioral Effects of Dopamine D3 Receptor-Selective Compounds in Monkeys (2012) (18)
- Effects of ( R)-Modafinil and Modafinil Analogues on Dopamine Dynamics Assessed by Voltammetry and Microdialysis in the Mouse Nucleus Accumbens Shell. (2019) (18)
- Dopamine D4 Receptor-Selective Compounds Reveal Structure–Activity Relationships that Engender Agonist Efficacy (2019) (18)
- Selective D2 and D3 receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens (2018) (18)
- Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders (2019) (18)
- Radioiodinated azide and isothiocyanate derivatives of cocaine for irreversible labeling of dopamine transporters: synthesis and covalent binding studies. (2005) (18)
- Transport, Metabolism, and in Vivo Population Pharmacokinetics of the Chloro Benztropine Analogs, a Class of Compounds Extensively Evaluated in Animal Models of Drug Abuse (2007) (18)
- Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways (2010) (18)
- Release of Ca2+ from heart and kidney mitochondria by peripheral-type benzodiazepine receptor ligands. (1991) (18)
- A novel photoaffinity label for the dopamine transporter based on N-substituted 3α-[bis(4′-fluorophenyl)methoxy]tropane (1997) (17)
- Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression (2010) (17)
- Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5. (2010) (17)
- The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats (2009) (17)
- Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter (2017) (16)
- Sigma receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain. (1988) (16)
- Computation-guided analysis of paroxetine binding to hSERT reveals functionally important structural elements and dynamics (2019) (16)
- Newly Developed Dopamine D3 Receptor Antagonists, R-VK4-40 and R-VK4-116, Do Not Potentiate Cardiovascular Effects of Cocaine or Oxycodone in Rats (2019) (16)
- Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes. (2001) (16)
- Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. (2014) (15)
- Probes for the Dopamine Transporter: New Leads Toward a Cocaine‐Abuse Therapeutic — A Focus on Analogues of Benztropine and Rimcazole (2002) (15)
- Novel azido and isothiocyanato analogues of [3-(4-phenylalkylpiperazin-1-yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter. (2004) (15)
- R-Modafinil Attenuates Nicotine-Taking and Nicotine-Seeking Behavior in Alcohol-Preferring Rats (2015) (14)
- Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5. (2011) (14)
- Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2β-carbomethoxy-3β-biphenyltropane (2006) (14)
- Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter (2008) (14)
- Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation. (2006) (14)
- Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats (2018) (13)
- Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders. (2017) (13)
- Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia. (2019) (13)
- Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini* (2016) (13)
- Influence of Cocaine History on the Behavioral Effects of Dopamine D3 Receptor-Selective Compounds in Monkeys (2011) (13)
- Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. (2012) (13)
- Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66. (2014) (13)
- Hormonal regulation of adipocyte particulate "low Km" cAMP phosphodiesterase. (1986) (12)
- Evidence for a stereoselective mechanism for bitopic activity by extended-length antagonists of the D3 dopamine receptor. (2020) (12)
- Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons (2017) (12)
- Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors. (2006) (12)
- Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol. (2008) (12)
- Characterization of the effects of AHN 086, an irreversible ligand of "peripheral" benzodiazepine receptors, on contraction in guinea-pig atrial and ileal longitudinal smooth muscle. (1989) (12)
- Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen. (1993) (11)
- Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives. (2004) (11)
- [3H]MFZ 2-12: a novel radioligand for the dopamine transporter. (2001) (11)
- Presence of peripheral benzodiazepine binding sites on primary rat skeletal fibroblasts. (1990) (11)
- Distinct effects of (R)‐modafinil and its (R)‐ and (S)‐fluoro‐analogs on mesolimbic extracellular dopamine assessed by voltammetry and microdialysis in rats (2018) (11)
- Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach (2019) (11)
- Highly selective σ1 ligands based on dextromethorphan (1996) (11)
- A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter. (2013) (11)
- Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan (2003) (10)
- Structure-Activity Relationships for a series of bis(4-fluorophenyl)methyl)sulfinyl)alkyl alicyclic amines at the dopamine transporter: functionalizing the terminal nitrogen affects affinity, selectivity and metabolic stability. (2020) (10)
- [3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter. (2001) (10)
- Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats (2014) (10)
- Irreversible ligands as probes for drug receptors. (1991) (9)
- Enantioselective synthesis of S-(+)-2β-carboalkoxy-3α-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter (2002) (9)
- Purification, properties and polyclonal antibodies for the particulate, low Km cAMP phosphodiesterase from bovine adipose tissue. (1988) (9)
- Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram (2015) (9)
- Novel benztropine [3a-(diphenylmethoxy)tropane] analogs as probes for the dopamine transporter. (1998) (9)
- The role of cyclic nucleotides in the action of peripheral-type benzodiazepine receptor ligands in rat aorta. (1994) (9)
- A novel mGluR 5 antagonist , MFZ 10-7 , inhibits cocaine-taking and cocaine-seeking behavior in rats (2019) (8)
- Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues). (1992) (8)
- Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters (2020) (8)
- Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management. (2021) (8)
- Medicinal Chemistry: New Chemical Classes and Subtype-Selective Ligands (2007) (8)
- Modafinil potentiates cocaine self-administration by a dopamine-independent mechanism: possible involvement of gap junctions (2020) (8)
- The potent opioid agonist, (+)-cis-3-methylfentanyl binds pseudoirreversibly to the opioid receptor complex in vitro and in vivo: evidence for a novel mechanism of action. (1990) (8)
- Precursors of the mammalian synthesis of morphine: (+)‐salutaridine and (−)‐thebaine from (+)‐6‐demethylsalutaridine, and (−)‐N‐13CH3‐thebaine from (−)‐northebaine (1986) (8)
- Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter. (2020) (7)
- Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms (2020) (7)
- The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor. (2004) (7)
- Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D3R Bitopic Agonists. (2020) (7)
- Novel 1-phenylcycloalkanecarboxylic acid derivatives as potential anticonvulsant agents. (1991) (7)
- Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter. (2003) (7)
- Psychostimulant Use Disorder, an Unmet Therapeutic Goal: Can Modafinil Narrow the Gap? (2021) (7)
- High-performance fast affinity chromatographic purification of anti-benzodiazepine antibodies. (1986) (6)
- Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D2/D3 Receptor Bitopic Ligands. (2021) (6)
- A novel Bromine-containing paroxetine analog provides mechanistic clues for binding ambiguity at the central primary binding site of the serotonin transporter. (2019) (6)
- (+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepine analogs: novel dopamine D1 receptor antagonists. (1996) (6)
- Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity (2022) (6)
- BBB transport and rapid tissue binding of cyclofoxy: comparison of active and inactive enantiomers. (1990) (6)
- Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability. (2020) (6)
- AHN 683: a fluorescent ligand for peripheral-type benzodiazepine receptors. (1992) (6)
- (±)VK4‐40, a novel dopamine D3 receptor partial agonist, attenuates cocaine reward and relapse in rodents (2020) (6)
- Aprophit: an irreversible antagonist for muscarinic receptors. (1990) (6)
- Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder. (2020) (6)
- Chiral aminophosphonate eluent for enantiomeric analysis of amino acids. (1996) (6)
- A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus (2016) (6)
- Current Perspectives on Selective Dopamine D3 Receptor Antagonists/Partial Agonists as Pharmacotherapeutics for Opioid and Psychostimulant Use Disorders. (2022) (5)
- Design and Synthesis of Fluorescent Methylphenidate Analogues for a FRET‐Based Assay of Synapsin III Binding (2020) (5)
- N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands. (2005) (5)
- A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder (2022) (5)
- Chapter 29. Irreversible Ligands for Drug Receptor Characterization (1990) (5)
- Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D3 Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders (2021) (5)
- Preferential Gs protein coupling of the galanin Gal1 receptor in the µ-opioid-Gal1 receptor heterotetramer. (2022) (5)
- 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile. (1997) (5)
- Yawning elicited by intravenous ethanol in rhesus monkeys with experience self-administering cocaine and ethanol: Involvement of dopamine D3 receptors. (2017) (5)
- Applicability of the Dopamine and Rate Hypotheses in Explaining the Differences in Behavioral Pharmacology of the Chloro-Benztropine Analogs: Studies Conducted Using Intracerebral Microdialysis and Population Pharmacodynamic Modeling (2007) (4)
- Effects of the selective dopamine D3 receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice (2020) (4)
- Enantioselective Synthesis of S‐(+)‐2β‐Carboalkoxy‐3α‐[bis(4‐fluorophenyl)methoxy]tropanes as Novel Probes for the Dopamine Transporter. (2002) (4)
- Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease (2021) (4)
- The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse. (2008) (4)
- A Diastereospecific Synthesis of 2-Methyl-5beta-phenyl-5alpha-carbethoxy-2- azabicyclo[2.2.1]heptane: A Ring-Constrained Analogue of Meperidine. (1998) (4)
- Drinking sucrose enhances quinpirole-induced yawning in rats (2011) (4)
- Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy (2020) (4)
- Beyond small-molecule SAR: Using the dopamine D3 receptor crystal structure to guide drug design (2018) (3)
- Identification of the benztropine analog [125I]GA II 34 binding site on the human dopamine transporter (2019) (3)
- Erratum: 2-isoxazol-3-phenyltropane derivatives of cocaine: Molecular and atypical system effects at the dopamine transporter (Journal of Pharmacology and Experimental Therapeutics (2014) 349 (297-309) DOI:10.1124/jpet.113.212738) (2014) (3)
- Pharmacological targeting of G protein-coupled receptor heteromers. (2022) (3)
- Population pharmacokinetics, brain distribution, and pharmacodynamics of 2nd generation dopamine transporter selective benztropine analogs developed as potential substitute therapeutics for treatment of cocaine abuse. (2008) (3)
- Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D2 or D3 Receptor Agonists. (2021) (3)
- Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor (2021) (3)
- Novel 1-Phenylcycloalkanecarboxylic Acid Derivatives are Potent and Selective σ1 Ligands. (1994) (3)
- Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi‐site molecular tethering of photoactive cocaine analogs (2017) (3)
- MOL # 43679 1 LABELING OF DOPAMINE TRANSPORTER TRANSMEMBRANE DOMAIN 1 WITH THE TROPANE LIGAND [ 125 I ] MFZ 2-24 IMPLICATES PROXIMITY OF COCAINE AND SUBSTRATE ACTIVE SITES (2008) (2)
- Synthesis and Evaluation of 3‐Substituted 17‐Methylmorphinan Analogs as Potential Anticonvulsant Agents. (1993) (2)
- Purification of a cGMP-inhibited cAMP Phosphodiesterase from Vascular Smooth Muscle (1990) (2)
- Pro-erectile Effects of Dopamine D 2 -like Agonists are Mediated by the D 3 Receptor in Rats and Mice (2008) (2)
- Dog neutrophil stimulation and cell surface expression of heat shock proteins induced by AHN 086. (1995) (2)
- Biased G Protein-Independent Signaling of Dopamine D1-D3 Receptor Heteromers in the Nucleus Accumbens (2019) (2)
- A tropane-based ibogaine analog rescues folding-deficient SERT and DAT (2020) (2)
- N-Substituted-3-alkoxy-derivatives of dextromethorphan are functional NMDA receptor antagonists in vivo: Evidence from an NMDA-induced seizure model in rats (2021) (2)
- [O-methyl-11C]N-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1H-indole-2-carboxamide ([11C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D3 Receptors in Rodents and Monkey (2018) (2)
- Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram. (2021) (2)
- AHN649: Preclinical Evaluation of a Novel Anticonvulsant and Neuroprotective Analog of Dextromethorphan (1997) (1)
- A Novel PKC Inhibitor Shows Promise for Amphetamine Use Disorders (2017) (1)
- A Diastereospecific Synthesis of 2-Methyl-5β-phenyl-5α-carbethoxy-2-azabicyclo[2.2.1]heptane: A Ring-Constrained Analogue of Meperidine. (1998) (1)
- Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter. (2002) (1)
- Quaternary Benzazepine Analogues Lack Affinity for Dopamine‐D1 Receptors. (1994) (1)
- [3H]MFZ 2‐12: A Novel Radioligand for the Dopamine Transporter (2001) (1)
- Methylphenidate Analogues as a New Class of Potential Disease-Modifying Agents for Parkinson’s Disease: Evidence from Cell Models and Alpha-Synuclein Transgenic Mice (2022) (1)
- 3,4-Methylenedioxypyrovalerone High-Responder Phenotype as a Tool to Evaluate Candidate Medications for Stimulant Use Disorder (2023) (1)
- Missense mutations in the dopamine transporter gene associate with adult parkinsonism and ADHD Supplementary Information (2014) (1)
- Cocaine increases the stimulation of dopamine release, at variance with atypical dopamine uptake inhibitors. New clues for the abuse liability of psychostimulants? (2019) (1)
- Cocaine analogue conjugated magnetic nanoparticles for labeling and imaging dopaminergic neurons. (2020) (1)
- Correction: Corrigendum: A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter (2013) (1)
- 6.07 – Addiction (2007) (1)
- Total synthesis of northebaine, normorphine, noroxymorphonenantiomerer and derivatives via the N-nor intermediates (1990) (1)
- Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane. (2006) (1)
- Potent analgesia, respiratory depression, dependence, abuse liability-clue to separability. (1992) (1)
- BENZTROPINE, A POTENTIAL TREATMENT FOR COCAINE DEPENDENCE: DISCRIMINATIVE STIMULUS EFFECTS (1996) (1)
- Photoaffinity‐Mediated Identification of a Third Citalopram Analog Binding Site on the Serotonin Transporter (2018) (1)
- Erratum: Influence of cocaine history on the behavioral effects of dopamine d3 receptor-selective compounds in monkeys (Neuropsychopharmacology (2011) 36 (1104-1113) DOI: 10.1038/npp.2010.248) (2012) (1)
- Ligands for imaging opioid receptors in conscious humans by positron emission tomography (PET). (1988) (1)
- Effects of buprenorphine, methadone, and cariprazine on economic choice between remifentanil and food in squirrel monkeys. (2023) (1)
- Poster Session III (2005) (0)
- Behavioral and Neurochemical Effects of the Dopamine Transporter Ligand 4-Chlorobenztropine Alone and in Combination with Cocaine In Vivo 1 (1999) (0)
- Fluorescent probes for peripheral-type benzodiazepine receptor visualization and localization. (1989) (0)
- Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux (2022) (0)
- Synthesis and Anticonvulsant Activity of 4-Amino-(N-1-arylcycloalkyl) benzamides. (2010) (0)
- Interactions of Modafinil or Methylphenidate with the Reinforcing and Neurochemical Effects of Cocaine (2015) (0)
- Dopamine D3 receptor availability: Sex differences and effects of chronic drug exposure (2015) (0)
- Long-Term Cocaine Exposure Affects Dopamine D3 Receptor Function (2014) (0)
- Synthesis and biochemical characterization of two novel irreversible ligands specific for "peripheral" benzodiazepine receptors. (1987) (0)
- B39 ANTAGONISM OF THE STIMULANT EFFECTS OF COCAINE BY THE DOPAMINE TRANSPORTER LIGAND, JHW007 (2005) (0)
- Nanopharmacological Force Sensing Reveals Two Ligand Binding Sites in Monoamine Transporters (2016) (0)
- Novel Benztropine [3a-(Diphenylmethoxy)tropane] Analogs as Probes for the Dopamine Transporter (1998) (0)
- Two Distinct Ligand Binding Sites in Monoamine Transporters Monitored by Nanopharmacological Force Sensing (2020) (0)
- N-8-Substituted Benztropinamine Analogues as Selective Dopamine Transporter Ligands. (2006) (0)
- Effects of the novel dopamine D3 compound PG 619 on cocaine‐food choice in rhesus monkeys (2011) (0)
- Methylphenidate modifies the motion of the circadian clock Lamotrigine in mood disorders and cocaine dependence Cortical glutamate in postpartum depression The Novel Modafinil Analog , JJC 8-016 , as a Potential Cocaine Abuse Pharmacotherapeutic (2017) (0)
- Effects of chronic treatment with the D3 receptor‐selective compound PG619 on cocaine (COC) self‐administration and FDG brain activity in rhesus monkeys (2013) (0)
- A Medicinal Chemist's Journey at the National Institutes of Health One Molecule at a Time. (2020) (0)
- A dominant-negative variant in the dopamine transporter PDZ-binding motif is linked to parkinsonism and neuropsychiatric disease (2020) (0)
- Discriminative‐stimulus effects of 3,4‐methylenedioxy‐N‐methylamphetamine (MDMA) and a novel MDMA quatenary analog (2013) (0)
- Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats (2018) (0)
- Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change (2013) (0)
- Decision letter: Chemical and structural investigation of the paroxetine-human serotonin transporter complex (2020) (0)
- Effects of Drugs on Visual Stimulus Control of Behavior in an Analog of a Drug‐Discrimination Procedure (2007) (0)
- Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms (2020) (0)
- Franklin Robinson memorial symposium on medicinal chemistry in drug abuse research (1995) (0)
- Novel Dopamine D4 Receptor‐Selective Compounds Reveal Structure‐Activity Relationships that Engender Agonist Efficacy (2019) (0)
- Dopamine D3/D2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders. (2023) (0)
- Elucidating the effects of typical and atypical dopamine uptake inhibitors on the phasic release of dopamine in mice (2018) (0)
- Attenuation of Cocaine Self‐Administration by Dual Inhibition of the Dopamine Transporter and Sigma Receptors (2009) (0)
- Identification of the attachment site for the cocaine analog [125I]JHC 2‐48 on the dopamine transporter (803.7) (2014) (0)
- (±)-Modafinil potentiates cocaine self-administration but not the effects on DA levels in rodents (2015) (0)
- 1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS (2013) (0)
- Can the Stereotypy‐Inducing Effects of Atypical Dopamine Uptake Inhibitors Account for Their Blockade of Cocaine Self Administration? (2012) (0)
- [3H]AHN 070: a high affinity irreversible radioligand for characterization of peripheral benzodiazepine receptors. (1990) (0)
- In vivo Evaluation of the Specificity of Novel Drugs Targeting Dopamine D3 receptors using MRI: Role of Positive and Negative Hemodynamic Indices (2009) (0)
- Relationship between apparent in vivo occupancy at the dopamine transporter and cocaine‐like discriminative stimulus effects of N‐substituted benztropine analogs in mice (803.4) (2014) (0)
- [3‐cis‐3,5‐Dimethyl‐(1‐piperazinyl)alkyl]‐bis‐(4′‐fluorophenyl)amine Analogues as Novel Probes for the Dopamine Transporter. (2002) (0)
- Total synthesis of northebain-, normorphin-, noroxymorphone enantiomeric and derivatives via N-nor-intermediate compounds (1990) (0)
- The Effects of the Dopamine Transporter Ligands JJC8-088 and JJC8-091 on Cocaine versus Food Choice in Rhesus Monkeys (2022) (0)
- Synthese totale d'enantiomeres et de derives de northebaine, normorphine, neuroxymorphone par des intermediaires n-nor (1990) (0)
- Characterization of the Effects of Standard and Atypical Dopamine Uptake Inhibitors and Other Centrally Acting Drugs on the EEG of Freely Moving Rats (2018) (0)
- AD-POO 8 801 Dextromethorphan Analogs : Receptor Binding and Pharmacological Profile of Novel Anticonvulsant / Neuroprotective Drugs (0)
- Corrigendum: Design and Synthesis of Fluorescent Methylphenidate Analogues for a FRET‐Based Assay of Synapsin III Binding (2022) (0)
- Effects of Dopamine D3 Receptor Compounds on Oxycodone Self‐Administration, Reinstatement and Antinociception in Monkeys (2019) (0)
- Gap Junctions Modulate The Effects Of Modafinil On Cocaine Self‐Administration Behavior In A Dopamine‐Independent Fashion In Rats (2020) (0)
- Effects of selective dopamine D3 receptor partial agonist/antagonists on oxycodone self-administration and antinociception in monkeys. (2023) (0)
- Subjective Effect of Monoamine Uptake Inhibitors in Rats Trained to Discriminate Citalopram (2007) (0)
- Cocaine Photo‐affinity Analogs Bind in the S1 Binding Pocket of the Dopamine Transporter Providing a Mechanism for Competitive Inhibition of Dopamine Uptake (2015) (0)
- Differential effects of dopamine transporter inhibitors on cocaine‐stimulated dopamine neurotransmission (2006) (0)
- Structurally Similar and Behaviorally Unique Modafinil Analogs as Potential Pharmacotherapeutics for Psychostimulant Use Disorder (2019) (0)
- A Novel Photoaffinity Label for the Dopamine Transporter Based on N-Substituted 3α-[Bis(4′-fluorophenyl)methoxy]tropane. (1998) (0)
- Development of Drugs with Dual Dopamine Transporter and Sigma1 Receptor Activity (2009) (0)
- Chirality of novel bitopic agonists determine unique pharmacology at the dopamine 2 and 3 receptors (2020) (0)
- Novel Potent 5-HT1a Agonists Selective over alpha1-Adrenoceptor Subtypes (2016) (0)
- Relationship of the crystal structure of γ-N,N-dimethylaminopropyl 2,2-diphenylpropionate hydrochloride to antimuscarinic activity (1992) (0)
- Dynamic Turnover of FtsZ-Ring in Live Cell (2015) (0)
- Synthesis and anticonvulsant activity of dextromethorphan analogs. (1990) (0)
- Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans (2013) (0)
- Behavioral effects and dopamine antagonist properties of N‐alkylaminobenzazepines (1996) (0)
- [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland. (1989) (0)
- Visualizing the binding mode of the antidepressant vilazodone on the serotonin transporter by cryo-EM (2022) (0)
- Dopamine D2/D3 receptor modulation of food-drug choice in rhesus monkeys (2015) (0)
- Evidence for a Stereoselective Mechanism of Action for Non‐competitive Antagonism of the D3 Dopamine Receptor by Extended‐Length Bitopic Ligands (2018) (0)
- Evaluation of N‐Substituted Benztropine (BZT) Analogs for Cocaine Antagonist Effects in Rats Trained to Self‐Administer Cocaine (2010) (0)
- Effects of selective dopamine D3 receptor compounds in nonhuman primate models of cocaine and methamphetamine abuse (661.8) (2014) (0)
- Illuminating the monoamine transporters: fluorescently labelled ligands to study DAT, SERT, and NET. (2022) (0)
- Novel sumanirole bivalent analogues as potent dopamine D2 receptor Go‐protein biased agonists (2019) (0)
- TESTING D2-LIKE RECEPTOR AFFINITY AND SELECTIVITY WITHNOVEL IMIDAZOLINE DERIVATIVES (2013) (0)
- Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter (2017) (0)
- The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders (2013) (0)
- Effects of Selective Dopamine D2 or D3 Receptor Antagonism on Morphine-Induced Locomotion in Mice (2020) (0)
- Pet imaging of opiate receptor binding in human epilepsy using fluorine 18 cyclofoxy (1990) (0)
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