Amy K. LeBlanc
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American veterinarian scientist
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Amy K. LeBlancphilosophy Degrees
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Philosophy
Amy K. LeBlanc's Degrees
- Bachelors Biology University of California, Davis
- Doctorate Veterinary Medicine University of California, Davis
- PhD Veterinary Science Cornell University
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Why Is Amy K. LeBlanc Influential?
(Suggest an Edit or Addition)According to Wikipedia, Amy K. LeBlanc is an American veterinary oncologist and biologist researching animal modeling for development of new cancer drugs and imaging agents, and identification of imaging biomarkers, development and optimization of PET imaging hardware and imaging protocols. She is a senior scientist in the molecular imaging program and director of the Comparative Oncology Program at the National Cancer Institute. LeBlanc was previously an associate professor at the University of Tennessee College of Medicine and College of Veterinary Medicine.
Amy K. LeBlanc's Published Works
Published Works
- Masitinib is safe and effective for the treatment of canine mast cell tumors. (2008) (258)
- Launching a Novel Preclinical Infrastructure: Comparative Oncology Trials Consortium Directed Therapeutic Targeting of TNFα to Cancer Vasculature (2009) (113)
- CCNU for the treatment of dogs with histiocytic sarcoma. (2007) (106)
- Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology (2016) (103)
- Response of canine cutaneous epitheliotropic lymphoma to lomustine (CCNU): a retrospective study of 46 cases (1999-2004). (2006) (76)
- A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma (2018) (73)
- Improving human cancer therapy through the evaluation of pet dogs (2020) (63)
- Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients. (2016) (63)
- 18FDG-PET imaging in canine lymphoma and cutaneous mast cell tumor. (2009) (53)
- Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma (2020) (51)
- Defining the Value of a Comparative Approach to Cancer Drug Development (2015) (51)
- Unexpected toxicity following use of gemcitabine as a radiosensitizer in head and neck carcinomas: a veterinary radiation therapy oncology group pilot study. (2004) (50)
- Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma (2015) (48)
- Safety studies on intravenous administration of oncolytic recombinant vesicular stomatitis virus in purpose-bred beagle dogs. (2013) (43)
- Comparative Oncology Evaluation of Intravenous Recombinant Oncolytic Vesicular Stomatitis Virus Therapy in Spontaneous Canine Cancer (2017) (42)
- Comparative molecular life history of spontaneous canine and human gliomas (2019) (37)
- Metabolomics uncovers a link between inositol metabolism and osteosarcoma metastasis (2017) (36)
- NCI Comparative Oncology Program Testing of Non-Camptothecin Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma (2018) (33)
- Diet modulates proteinuria in heterozygous female dogs with X-linked hereditary nephropathy. (2004) (32)
- C-kit Expression in Canine Mucosal Melanomas (2012) (32)
- Near infrared photoimmunotherapy targeting bladder cancer with a canine anti-epidermal growth factor receptor (EGFR) antibody (2018) (31)
- Guidance for Methods Descriptions Used in Preclinical Imaging Papers (2013) (31)
- Preliminary evaluation of serial (18) FDG-PET/CT to assess response to toceranib phosphate therapy in canine cancer. (2012) (31)
- Advanced imaging for veterinary cancer patients. (2007) (31)
- CCNU for the Treatment of Dogs with Histiocytic Sarcoma (2007) (31)
- Efficacy and toxicity of BOPP and LOPP chemotherapy for the treatment of relapsed canine lymphoma. (2006) (31)
- PET and SPECT imaging in veterinary medicine. (2014) (23)
- Normal thoracic and abdominal distribution of 2-deoxy-2-[18F]fluoro-D-glucose (18FDG) in adult cats. (2009) (23)
- Expression of PDGFR-β and Kit in canine anal sac apocrine gland adenocarcinoma using tissue immunohistochemistry. (2012) (22)
- Carcinoma ex Pleomorphic Adenoma with Sebaceous Differentiation in the Mandibular Salivary Gland of a Dog (2006) (22)
- Consensus recommendations on standardized magnetic resonance imaging protocols for multicenter canine brain tumor clinical trials (2018) (21)
- Evaluation of peripheral blood neutrophil function in tumor-bearing dogs. (2009) (19)
- A One Health overview, facilitating advances in comparative medicine and translational research (2016) (18)
- A Comparative Oncology Study of Iniparib Defines Its Pharmacokinetic Profile and Biological Activity in a Naturally-Occurring Canine Cancer Model (2016) (17)
- Effects of L-asparaginase on plasma amino acid profiles and tumor burden in cats with lymphoma. (2007) (17)
- Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma (2017) (15)
- Evaluation of CT-based lean-body SUV. (2013) (15)
- Asparaginase-associated pancreatitis in a dog. (2011) (15)
- Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs. (2016) (14)
- CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies (2019) (14)
- Development of a quantitative pharmacodynamic assay for apoptosis in fixed tumor tissue and its application in distinguishing cytotoxic drug—induced DNA double strand breaks from DNA double strand breaks associated with apoptosis (2018) (13)
- Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs (2021) (12)
- Magnetic resonance imaging of canine mast cell tumors. (2012) (12)
- Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers (2019) (11)
- Flow cytometric evaluation of multidrug resistance proteins on grossly normal canine nodal lymphocyte membranes. (2008) (10)
- Cancer and comparative imaging. (2014) (10)
- Radiotherapy-induced myelosuppression in dogs: 103 cases (2002-2006). (2012) (10)
- Canine and murine models of osteosarcoma (2022) (9)
- Serial evaluation of neutrophil function in tumour-bearing dogs undergoing chemotherapy. (2015) (8)
- Distribution of 2-deoxy-2-fluoro-d-glucose in the coelom of healthy bald eagles (Haliaeetus leucocephalus). (2013) (7)
- Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species (2021) (6)
- Advanced Cancer Imaging Applied in the Comparative Setting (2020) (5)
- Whole-body biodistribution of 3'-deoxy-3'-[(18) f]fluorothymidine ((18) FLT) in healthy adult cats. (2013) (5)
- A Large Volume PET Scanner for Low Dose Applications (2006) (4)
- Diet modulates proteinuria in heterozygous female dogs with X-linked hereditary nephropathy (2004) (4)
- [Proteinuria in mature diabetic patients. Quantitative and qualitative analysis]. (1975) (3)
- Charting a path for prioritization of novel agents for clinical trials in osteosarcoma: A report from the Children's Oncology Group New Agents for Osteosarcoma Task Force (2021) (3)
- Sodium Fluoride-18 and Radium-223 Dichloride Uptake Colocalize in Osteoblastic Mouse Xenograft Tumors. (2021) (3)
- Kinetic analysis of 2-([(18)F]fluoro)-2-deoxy-d-glucose uptake in brains of anesthetized healthy dogs. (2014) (3)
- Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs (2022) (2)
- Identification of potential modulators of osteosarcoma metastasis by high‐throughput cellular screening of natural products (2020) (2)
- A Report from the NCI Comparative Brain Tumor Consortium (CBTC) Glioma Pathology Board: A Revised Diagnostic Classification in Support of Validation of the Canine Glioma Patient as a Model for Humans (2019) (2)
- Normal Thoracic And Abdominal Distribution Of 2-Deoxy-2-[ 18 f]Fluoro-D-Glucose ( 18 FDG) With Positron Emission Tomography In Adult Cats (2009) (2)
- Microfluidic synthesis of [18F]FLT (2010) (2)
- Early findings from a comparative oncology study evaluating systemic VSV therapy in client-owned dogs with spontaneous hematologic malignancies (2014) (2)
- What is your diagnosis? Diagnostic imaging findings and interpretation. (2008) (2)
- Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma (2020) (1)
- Relative skeletal distribution of proliferating marrow in the adult dog determined using 3′‐deoxy‐3′‐[18F]fluorothymidine (2018) (1)
- Deep Domain Adversarial Learning for Species-Agnostic Classification of Histologic Subtypes of Osteosarcoma (2022) (1)
- What is your diagnosis? Mucometra in a Cat. (2008) (1)
- 70. Safety, Toxicity and Efficacy of Systemic Recombinant VSV Therapy in Pet Dogs With Spontaneous Cancer (2015) (1)
- Effects of L‐Asparaginase on Plasma Amino Acid Profiles and Tumor Burden in Cats with Lymphoma (2007) (1)
- Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients. (2021) (1)
- Antitumor activity of indenoisoquinoline inhibitors of topoisomerase 1 (TOP1) via apoptosis and autophagocytosis pathways in animal models. (2017) (1)
- Impact of limb amputation and cisplatin chemotherapy on metastatic progression in mouse models of osteosarcoma (2021) (1)
- MPA PASS Enables Stitched Multiplex Multi-Dimensional EV Repertoire Analysis (2021) (0)
- What is your diagnosis? Mucometra. (2008) (0)
- Efficacy of C/B-OPP rescue for the treatment of relapsed canine lymphoma (1998–2004) (2005) (0)
- Improving human cancer therapy through the evaluation of pet dogs (2020) (0)
- Abstract LB-B01: The anti-platelet-derived growth factor receptor α antibody olaratumab (Lartruvo) increases overall survival in metastatic mouse models of human osteosarcoma (2018) (0)
- CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies (2018) (0)
- Synthesis of novel near-infrared (NIR) cyanine dyes (2011) (0)
- Effects of L-asparaginase on tumor burden in cats with lymphoma (2007) (0)
- Abstract 4517: Plasma and tumor pharmacokinetics of IV LMP744, a novel indenoisoquinoline topoisomerase I inhibitor, in a canine phase I study (2015) (0)
- Invited review--Off-site PET imaging programs: challenges and opportunities. (2014) (0)
- Specific binding of heparin-reactive peptides with melanoma in vitro and in vivo (2012) (0)
- CCNU for t he Treatment of D ogs w ith Histiocytic Sarcoma (2007) (0)
- Abstract 6134: A comparative oncology approach to biomarker and drug discovery for cancer diagnosis and treatment in dogs and humans (2020) (0)
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Amy K. LeBlanc is affiliated with the following schools: