Ana Maria Cuervo
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Spanish scientist and biochemist
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Why Is Ana Maria Cuervo Influential?
(Suggest an Edit or Addition)According to Wikipedia, Ana Maria Cuervo is a Spanish-American physician, researcher, and cell biologist. She is a professor in developmental and molecular miology, anatomy and structural biology, and medicine and co-director of the Institute for Aging Studies at the Albert Einstein College of Medicine. She is best known for her research work on autophagy, the process by which cells recycle waste products, and its changes in aging and age-related diseases.
Ana Maria Cuervo's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Guidelines for the use and interpretation of assays for monitoring autophagy (2012) (6925)
- Autophagy fights disease through cellular self-digestion (2008) (5918)
- Autophagy regulates lipid metabolism (2009) (3068)
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008) (2360)
- Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy (2004) (1661)
- Geroscience: Linking Aging to Chronic Disease (2014) (1391)
- Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study (2005) (1360)
- Molecular definitions of autophagy and related processes (2017) (1036)
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations (2010) (1006)
- Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. (2004) (999)
- Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation (2018) (905)
- Autophagy gone awry in neurodegenerative diseases (2010) (864)
- A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes (1996) (855)
- Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease (2005) (848)
- Autophagy: in sickness and in health. (2004) (839)
- Autophagy and Aging: The Importance of Maintaining "Clean" Cells (2005) (770)
- Microautophagy of cytosolic proteins by late endosomes. (2011) (718)
- Autophagy regulates adipose mass and differentiation in mice. (2009) (712)
- Chaperone-mediated autophagy: a unique way to enter the lysosome world. (2012) (706)
- Chaperone-mediated autophagy: roles in disease and aging (2013) (700)
- HDAC6 controls autophagosome maturation essential for ubiquitin‐selective quality‐control autophagy (2010) (687)
- Autophagy in the cellular energetic balance. (2011) (675)
- Methods for Monitoring Autophagy from Yeast to Human (2007) (668)
- The coming of age of chaperone-mediated autophagy (2018) (642)
- Age-related Decline in Chaperone-mediated Autophagy* (2000) (598)
- Proteostasis and aging (2015) (574)
- Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. (2008) (570)
- Activation of chaperone-mediated autophagy during oxidative stress. (2004) (559)
- Oxidative stress and autophagy. (2006) (558)
- Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease (2012) (525)
- Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. (2009) (522)
- In search of an “autophagomometer” (2009) (518)
- Interplay of LRRK2 with chaperone-mediated autophagy (2013) (515)
- XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. (2009) (509)
- Autophagy and aging: keeping that old broom working. (2008) (504)
- Autophagy and neurodegeneration: when the cleaning crew goes on strike (2007) (488)
- Consequences of the selective blockage of chaperone-mediated autophagy. (2006) (471)
- Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function (2008) (456)
- Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis (2015) (430)
- The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane (2008) (428)
- Lipophagy: Connecting Autophagy and Lipid Metabolism (2012) (420)
- Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. (2011) (401)
- Chaperone-mediated autophagy. (2008) (400)
- Protein homeostasis and aging: The importance of exquisite quality control (2011) (396)
- Autophagy: Many paths to the same end (2004) (384)
- IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome (2009) (369)
- Functional interaction between autophagy and ciliogenesis (2013) (338)
- Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance. (2011) (332)
- Huntingtin Functions as a Scaffold for Selective Macroautophagy (2015) (331)
- Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. (2008) (312)
- Chaperone-mediated autophagy in aging and disease. (2006) (306)
- Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. (2016) (303)
- Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation. (1995) (299)
- Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. (2004) (299)
- Altered lipid content inhibits autophagic vesicular fusion (2010) (293)
- Integration of clearance mechanisms: the proteasome and autophagy. (2010) (287)
- A Population of Rat Liver Lysosomes Responsible for the Selective Uptake and Degradation of Cytosolic Proteins* (1997) (284)
- Autophagy in major human diseases (2021) (282)
- Autophagy and human disease: emerging themes. (2014) (277)
- Chaperone-mediated autophagy in protein quality control. (2011) (272)
- Unique properties of lamp2a compared to other lamp2 isoforms. (2000) (269)
- Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation (2010) (265)
- Protein degradation and aging (2005) (263)
- Autophagy and disease: always two sides to a problem (2012) (259)
- A comprehensive glossary of autophagy-related molecules and processes (2nd edition) (2011) (259)
- Autophagy Is Disrupted in a Knock-in Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis* (2006) (257)
- A comprehensive glossary of autophagy-related molecules and processes (2010) (253)
- Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. (2012) (250)
- Regulation of Liver Metabolism by Autophagy. (2016) (246)
- Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice (2017) (242)
- Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation (2010) (239)
- Lysosomal Degradation of α-Synuclein in Vivo* (2010) (238)
- Chaperone-mediated autophagy: selectivity pays off (2010) (238)
- Chaperone-mediated autophagy: molecular mechanisms and physiological relevance. (2010) (236)
- Proteostasis and the aging proteome in health and disease. (2014) (228)
- Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation. (2014) (227)
- When lysosomes get old☆ (2000) (224)
- Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy. (2015) (213)
- Lysosomes, a meeting point of proteins, chaperones, and proteases (1997) (210)
- Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease (2019) (209)
- Degradation of proteasomes by lysosomes in rat liver. (1995) (209)
- Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. (2010) (208)
- Programmed mitophagy is essential for the glycolytic switch during cell differentiation (2017) (205)
- Selective autophagy as a potential therapeutic target for neurodegenerative disorders (2018) (200)
- Chaperone-Mediated Autophagy Is Required for Tumor Growth (2011) (199)
- Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone (2017) (198)
- Chaperone-mediated autophagy at a glance (2011) (198)
- Pathophysiology of chaperone-mediated autophagy. (2004) (196)
- Lysosome membrane lipid microdomains: novel regulators of chaperone‐mediated autophagy (2006) (195)
- Identification of regulators of chaperone-mediated autophagy. (2010) (185)
- Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age (2007) (180)
- Inhibitory effect of dietary lipids on chaperone-mediated autophagy (2012) (176)
- Protein homeostasis and aging: taking care of proteins from the cradle to the grave. (2009) (175)
- Monomeric fluorescent timers that change color from blue to red report on cellular trafficking. (2009) (168)
- Cathepsin A regulates chaperone‐mediated autophagy through cleavage of the lysosomal receptor (2003) (166)
- Autophagy-mediated clearance of aggresomes is not a universal phenomenon. (2008) (163)
- Regulated Degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage (2015) (159)
- Liver autophagy: much more than just taking out the trash (2014) (158)
- A photoconvertible fluorescent reporter to track chaperone-mediated autophagy (2011) (157)
- Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives (2013) (150)
- AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA (2016) (150)
- Direct measurement of the dielectric polarization properties of DNA (2014) (148)
- Uptake and degradation of glyceraldehyde-3-phosphate dehydrogenase by rat liver lysosomes. (1993) (144)
- How Shall I Eat Thee? (2007) (142)
- Chaperone mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation (2014) (141)
- IκB Is a Substrate for a Selective Pathway of Lysosomal Proteolysis (1998) (140)
- Loss of Macroautophagy Promotes or Prevents Fibroblast Apoptosis Depending on the Death Stimulus*♦ (2008) (139)
- Balance between autophagic pathways preserves retinal homeostasis (2013) (137)
- Autophagy as a cell-repair mechanism: activation of chaperone-mediated autophagy during oxidative stress. (2006) (135)
- Constitutive Upregulation of Chaperone-Mediated Autophagy in Huntington's Disease (2011) (135)
- Characterization of chronic low‐level proteasome inhibition on neural homeostasis (2003) (134)
- Protein degradation, aggregation, and misfolding (2010) (129)
- Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging (2015) (129)
- Methods to monitor chaperone-mediated autophagy. (2009) (127)
- Selective binding and uptake of ribonuclease A and glyceraldehyde-3-phosphate dehydrogenase by isolated rat liver lysosomes. (1994) (127)
- Interplay of pathogenic forms of human tau with different autophagic pathways (2017) (125)
- Label-free identification of single dielectric nanoparticles and viruses with ultraweak polarization forces. (2012) (120)
- Chaperone‐mediated autophagy in health and disease (2010) (119)
- Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner (2012) (117)
- Selective Autophagy: Talking with the UPS (2013) (116)
- Inhibitory effect of intracellular lipid load on macroautophagy. (2010) (113)
- How do intracellular proteolytic systems change with age? (1998) (111)
- Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism. (2017) (110)
- Proteome-wide analysis of chaperone-mediated autophagy targeting motifs (2019) (110)
- Induction of Autophagy by Cystatin C: A Mechanism That Protects Murine Primary Cortical Neurons and Neuronal Cell Lines (2010) (110)
- Unifying Nomenclature for the Isoforms of the Lysosomal Membrane Protein LAMP‐2 (2005) (109)
- Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A (2018) (109)
- Connexins modulate autophagosome biogenesis (2014) (106)
- Autophagy: many paths to the same end. (2004) (104)
- Chaperone-mediated autophagy. (2010) (103)
- Role of chaperone‐mediated autophagy in metabolism (2016) (103)
- Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome (2021) (100)
- Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits. (2014) (96)
- Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99) (2019) (94)
- Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis (2011) (94)
- The lipid kinase PI4KIIIβ preserves lysosomal identity (2012) (94)
- Autophagy and the immune function in aging. (2014) (92)
- Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap (2018) (92)
- Chaperone-mediated autophagy dysfunction in the pathogenesis of neurodegeneration (2011) (92)
- Selective endosomal microautophagy is starvation-inducible in Drosophila (2016) (89)
- Selective autophagy in the maintenance of cellular homeostasis in aging organisms (2012) (88)
- Chaperone-mediated autophagy in aging and neurodegeneration: Lessons from α-synuclein (2007) (87)
- Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation (2010) (86)
- LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. (1996) (85)
- Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway. (2012) (81)
- Direct lysosomal uptake of α2-microglobulin contributes to chemically induced nephropathy (1999) (80)
- Chaperone-mediated autophagy sustains hematopoietic stem cell function (2020) (80)
- Selective Degradation of Annexins by Chaperone-mediated Autophagy* (2000) (80)
- α-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2 (2015) (80)
- Autophagic pathways and metabolic stress (2010) (78)
- Autophagy, nutrition and immunology. (2012) (77)
- Age-related oxidative stress compromises endosomal proteostasis. (2012) (77)
- Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans (2018) (76)
- Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide (2015) (74)
- Early cellular changes after blockage of chaperone-mediated autophagy (2008) (73)
- Chasing the elusive mammalian microautophagy (2011) (71)
- Humanin is an endogenous activator of chaperone-mediated autophagy (2018) (67)
- IkappaB is a substrate for a selective pathway of lysosomal proteolysis. (1998) (67)
- Aging as a Biological Target for Prevention and Therapy. (2018) (66)
- Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation (2017) (66)
- A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy (2019) (64)
- Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD (2018) (64)
- Proteasome Failure Promotes Positioning of Lysosomes around the Aggresome via Local Block of Microtubule-Dependent Transport (2014) (64)
- Structural Characterization of the Bacteriophage T7 Tail Machinery*♦ (2013) (64)
- Chronic Expression of RCAN1-1L Protein Induces Mitochondrial Autophagy and Metabolic Shift from Oxidative Phosphorylation to Glycolysis in Neuronal Cells* (2012) (63)
- MOLECULAR DETERMINANTS OF SELECTIVE CLEARANCE OF PROTEIN INCLUSIONS BY AUTOPHAGY (2012) (62)
- Molecular Rearrangements Involved in the Capsid Shell Maturation of Bacteriophage T7*♦ (2010) (61)
- Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity (2011) (61)
- Glioblastoma ablates pericytes antitumor immune function through aberrant up-regulation of chaperone-mediated autophagy (2019) (60)
- Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice (2021) (60)
- PM02734 (Elisidepsin) Induces Caspase-Independent Cell Death Associated with Features of Autophagy, Inhibition of the Akt/mTOR Signaling Pathway, and Activation of Death-Associated Protein Kinase (2011) (60)
- Autophagy and primary cilia: dual interplay. (2016) (60)
- Autophagy and regulation of cilia function and assembly (2014) (59)
- The plasma membrane brings autophagosomes to life (2010) (56)
- The ULK1-FBXW5-SEC23B nexus controls autophagy (2018) (56)
- Malfolded protein structure and proteostasis in lung diseases. (2013) (56)
- Chaperones in autophagy. (2012) (55)
- PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. (2020) (53)
- A2E, a pigment of RPE lipofuscin, is generated from the precursor, A2PE by a lysosomal enzyme activity. (2008) (53)
- Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein. (2007) (52)
- Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy (2020) (51)
- Calorie restriction and aging: the ultimate "cleansing diet". (2008) (51)
- Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A (2017) (50)
- The different autophagy degradation pathways and neurodegeneration (2022) (50)
- Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy* (2016) (48)
- Structural Rearrangements between Portal Protein Subunits Are Essential for Viral DNA Translocation* (2007) (48)
- Stimulatory effect of vitamin C on autophagy in glial cells (2002) (47)
- Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy (2019) (47)
- Conformational Changes Leading to T7 DNA Delivery upon Interaction with the Bacterial Receptor* (2015) (47)
- Autophagy in neurons: it is not all about food. (2006) (46)
- Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis (2020) (45)
- Pros and Cons of Chaperone-Mediated Autophagy in Cancer Biology (2019) (45)
- Entering the lysosome through a transient gate by chaperone-mediated autophagy (2008) (44)
- Direct lysosomal uptake of alpha 2-microglobulin contributes to chemically induced nephropathy. (1999) (44)
- Autophagic Defects in Aging: Looking for an “Emergency Exit"? (2006) (44)
- Medical bioremediation: Prospects for the application of microbial catabolic diversity to aging and several major age-related diseases (2005) (42)
- Autophagy and the hallmarks of aging (2021) (42)
- Autophagy and lipids: tightening the knot (2010) (42)
- Phosphorylation‐Regulated Degradation of the Tumor‐Suppressor Form of PED by Chaperone‐Mediated Autophagy in Lung Cancer Cells (2014) (42)
- Nucleic acid packaging in viruses. (2013) (42)
- Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells. (2010) (42)
- Methods to study chaperone-mediated autophagy. (2015) (41)
- Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism (2019) (40)
- Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy (2021) (39)
- Annexin A2 promotes phagophore assembly by enhancing Atg16L+ vesicle biogenesis and homotypic fusion (2015) (38)
- Lysosomal Chat Maintains the Balance (2006) (38)
- HTT/Huntingtin in selective autophagy and Huntington disease: A foe or a friend within? (2015) (38)
- Autophagy's Top Chef (2011) (38)
- Disulfiram Treatment Normalizes Body Weight in Obese Mice. (2020) (36)
- Viral connectors for DNA encapsulation. (2012) (36)
- Direct Interaction of the Bacteriophage SPP1 Packaging ATPase with the Portal Protein* (2010) (36)
- The Role of Autophagy in Liver Diseases: Mechanisms and Potential Therapeutic Targets (2015) (36)
- Analysis of Chaperone-Mediated Autophagy. (2019) (33)
- Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. (2017) (33)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Autophagy and aging--when "all you can eat" is yourself. (2003) (32)
- Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy. (2022) (32)
- Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo (2020) (32)
- Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100 (2018) (32)
- Eat your heart out (2007) (32)
- Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging (2018) (27)
- Dietary lipids and aging compromise chaperone-mediated autophagy by similar mechanisms (2012) (26)
- In Vivo Remodeling of Altered Autophagy-Lysosomal Pathway by a Phosphopeptide in Lupus (2020) (25)
- ARDD 2020: from aging mechanisms to interventions (2020) (25)
- Autophagy and neurodegeneration (2007) (24)
- Lipases in lysosomes, what for? (2009) (23)
- Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia (2018) (23)
- Atomic structure of the Epstein-Barr virus portal (2019) (22)
- Geroscience in the Age of COVID-19 (2020) (21)
- Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis (2016) (20)
- Chaperone-Mediated Autophagy and Aging: A Novel Regulatory Role of Lipids Revealed (2007) (18)
- MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells (2020) (17)
- Molecular damage in aging (2021) (17)
- Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena. (2013) (16)
- Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response (2019) (16)
- Unique properties of lamp 2 a compared to other lamp 2 isoforms (16)
- Nanomechanical detection of Escherichia coli infection by bacteriophage T7 using cantilever sensors. (2019) (15)
- Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons (2018) (15)
- Protein Homeostasis and Aging (2011) (14)
- The negative effect of lipid challenge on autophagy inhibits T cell responses (2020) (14)
- Protective role of chaperone-mediated autophagy against atherosclerosis (2022) (14)
- HIV Nef and Antiretroviral Therapy Have an Inhibitory Effect on Autophagy in Human Astrocytes that May Contribute to HIV-Associated Neurocognitive Disorders (2020) (13)
- Selective autophagy and Huntingtin: learning from disease (2015) (13)
- Reciprocal regulation of chaperone-mediated autophagy and the circadian clock (2021) (13)
- Inhibitory effect of intracellular lipid load on macroautophagy (2010) (12)
- Characterization of the initial steps in the T7 DNA ejection process (2015) (12)
- Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis (2021) (11)
- TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy (2021) (11)
- Hydrodynamic size-based separation and characterization of protein aggregates from total cell lysates (2014) (10)
- Erratum to “Chaperone-mediated autophagy in aging and neurodegeneration: Lessons from α-synuclein” [Exp. Gerontol. 42 (2007) 120–128] (2008) (10)
- Preventing lysosomal fat indigestion (2013) (10)
- Gαq activation modulates autophagy by promoting mTORC1 signaling (2021) (8)
- Extending human healthspan and longevity: a symposium report (2021) (8)
- PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis. (2021) (8)
- Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells (2019) (7)
- Autophagy: An Alternative Degradation Mechanism for Misfolded Proteins (2010) (7)
- Changes in Lysosomes and Their Autophagic Function in Aging: The Comparative Biology of Lysosomal Function (2010) (6)
- Misfolded GBA/β-glucocerebrosidase impairs ER-quality control by chaperone-mediated autophagy in Parkinson disease (2022) (6)
- Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration (2022) (6)
- Assessment of mammalian endosomal microautophagy. (2021) (6)
- Structural characterization of T7 tail machinery reveals a conserved tubular structure among other Podoviridae family members and suggests a common mechanism for DNA delivery (2013) (5)
- HIV Increases the Inhibitory Impact of Morphine and Antiretrovirals on Autophagy in Primary Human Macrophages: Contributions to Neuropathogenesis (2021) (5)
- Chaperone-Mediated Autophagy Controls Proteomic and Transcriptomic Pathways to Maintain Glioma Stem Cell Activity (2022) (5)
- Autophagy and Aging (2012) (5)
- Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome (2020) (4)
- 5th Conference on Advances in Molecular Mechanisms Underlying Neurological Disorders (2013) (4)
- The ULK 1-FBXW 5SEC 23 B nexus controls autophagy 1 2 3 (4)
- P1-059: Cystatin B deletion in a mouse model of Alzheimer's disease, TgCRND8, ameliorates both autophagic-lysosomal and amyloid pathologies (2008) (4)
- Chaperone-mediated autophagy protects against atherosclerosis (2022) (4)
- Assisted assembly of bacteriophage T7 core components for genome translocation across the bacterial envelope (2021) (4)
- Quality Control: Maintaining molecular order and preventing cellular chaos. (2022) (3)
- Reduced endosomal microautophagy activity in aging associates with enhanced exocyst‐mediated protein secretion (2022) (3)
- 4th International Symposium on Autophagy: Exploiting the Frontiers of Autophagy Research (2007) (3)
- Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome (2020) (3)
- Observation of Bacteriophage Ultrastructure by Cryo-electron Microscopy. (2018) (3)
- LRRK2 G2019S Impairs Chaperone-Mediated Autophagy in Neurons (IN2-1.001) (2013) (2)
- The lysosomal proteome of senescent cells contributes to the senescence secretome (2022) (2)
- Leading Edge Commentary Geroscience : Linking Aging to Chronic Disease (2014) (2)
- Aging Cell: open access to all. (2014) (2)
- Transcription factor NRF2 modulates chaperone mediated autophagy through the regulation of LAMP2A (2018) (2)
- Announcements from your Editorial Team (2009) (2)
- Corrigendum: Annexin A2 promotes phagophore assembly by enhancing Atg16+ vesicle biogenesis and homotypic fusion (2015) (2)
- Aberrant Autophagy in Macrophages and Astrocytes after HIV Nef or Antiretroviral Treatment: Contribution to the Pathogenesis of HIV-associated Neurocognitive Disorders (2017) (2)
- Immunosurveillance, interferon, and autophagic networking in cancer: the PRKCI-ULK2 paradigm (2021) (2)
- Protein Degradation and the Lysosomal System (2009) (2)
- Selective Autophagy: Talking with the UPS (2013) (2)
- Circadian remodeling of the proteome by chaperone-mediated autophagy (2022) (2)
- Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice (2017) (2)
- Retraction: PM02734 (Elisidepsin) Induces Caspase-Independent Cell Death Associated with Features of Autophagy, Inhibition of the Akt/mTOR Signaling Pathway, and Activation of Death-Associated Protein Kinase (2013) (2)
- Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy (2018) (2)
- Protein Folding and Misfolding in Health and Disease (2010) (2)
- Selective autophagy in cellular quality control (2013) (1)
- Using a partial atomic model from medium-resolution cryo-EM to solve a large crystal structure (2021) (1)
- Faculty Opinions recommendation of Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline. (2019) (1)
- Defining the role of PLD3 in Alzheimer’s disease pathology (2021) (1)
- Beth Cindy Levine (1960–2020) (2020) (1)
- Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span (2021) (1)
- TSC1 loss-of-function increases risk for tauopathy by inducing tau acetylation and preventing autophagy-mediated tau clearance (2020) (1)
- Corrigendum: Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives (2013) (1)
- SARCOSINE IS UNIQUELY MODULATED BY AGING AND DIETARY RESTRICTION IN RODENTS AND HUMANS (2017) (1)
- Cytosolic glucocerebrosidase impairs alpha-synuclein degradation by blockade of chaperone-mediated autophagy (P3.050) (2018) (1)
- Chaperone-mediated autophagy regulates adipocyte differentiation (2022) (1)
- C. elegans granulins promote an age-associated decline in protein homeostasis via lysosomal protease inhibition (2018) (1)
- Methamphetamine Dysregulates Macrophage Functions and Autophagy to Mediate HIV Neuropathogenesis (2022) (1)
- Chaperone-mediated autophagy is a cytoprotective response of photoreceptors during aging and retinal diseases. (2019) (0)
- The coming of age of chaperone-mediated autophagy (2018) (0)
- POSTTRANSLATIONAL MODULATION OF MACROMOLECULES DURING AGING (2017) (0)
- S4-03-04 Autophagy in Alzheimer's disease pathogenesis (2004) (0)
- P4-080 Cystatin C protects neuronal cells against amyloid-β induced cytotoxicity (2006) (0)
- Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo (2020) (0)
- Mini-Review Protein degradation and aging (2005) (0)
- 32. Distinct features of disease phenotypes in two genetic models of NCL (2010) (0)
- Structure of gp8 connector protein (2013) (0)
- Editorial (2014) (0)
- Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons (2018) (0)
- Atomic structure of the Epstein-Barr portal, structure I (2019) (0)
- Autophagy in Disease and Aging (2006) (0)
- Autophagy and aging: connecting nutritional‐regulated catabolism and cellular quality control (2009) (0)
- Selective autophagy in the cellular stress response (237.3) (2014) (0)
- Selective autophagy in the maintenance of cellular homeostasis in aging organisms (2011) (0)
- TARGETING SELECTIVE AUTOPHAGY AGAINST PROTEOTOXICITY IN AGING AND AGE-RELATED DISEASES (2017) (0)
- Aging Cell Prize for Best Paper 2009 (2010) (0)
- Defining the role of PLD3 in Alzheimer disease pathology (2021) (0)
- Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy (2020) (0)
- Editorial (2013) (0)
- Reflections on the field of metabolism. (2015) (0)
- Transport Local Block of Microtubule-Dependent of Lysosomes around the Aggresome via Proteasome Failure Promotes Positioning (2014) (0)
- Aging Cell Prize for Best Paper 2012 (2013) (0)
- Sa1692 BVES Is Critical for Crowding Induced Cancer Cell Extrusion in Liver Cancer Metastasis (2014) (0)
- Reorganization of the shell protein during the maturation of bacteriophage T7 (2011) (0)
- The Envelope-Based Fusion Antigen GP120C14K Forming Hexamer-Like Structures Triggers T Cell and Neutralizing Antibody Responses Against HIV-1 (2019) (0)
- Faculty Opinions recommendation of Role of dietary amino acid balance in diet restriction-mediated lifespan extension, renoprotection, and muscle weakness in aged mice. (2018) (0)
- Aging and protein homeostasis (2016) (0)
- 2016 RAND Summer Institute (2017) (0)
- Farnesyl Transferase Inhibition for the Treatment of Tauopathies (2018) (0)
- Editorial (2011) (0)
- Announcement (2011) (0)
- Author response: The ULK1-FBXW5-SEC23B nexus controls autophagy (2018) (0)
- Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathy (2020) (0)
- Aging Cell Prize for Best Paper (2009) (0)
- Crystal structure of T7 bacteriophage portal protein, 13mer, closed valve - P212121 (2020) (0)
- Reconstructing the functional effect of TP53 somatic mutations on its regulon using causal signalling network modelling (2023) (0)
- Beth Levine in memoriam (2020) (0)
- Structure of T7 gatekeeper protein (gp11) (2013) (0)
- Lysosomal mTORC 2 / PHLP P 1 / Akt Regulate Chaperone-Mediated Autophagy Graphical Abstract Highlights (2015) (0)
- Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation (2018) (0)
- Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap (2018) (0)
- Webinar: Imaging the Sustainable Cell (2012) (0)
- Faculty Opinions recommendation of MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age. (2014) (0)
- Inhibition of chaperone-mediated autophagy may be a novel approach to increase platinum susceptibility in ovarian cancer cell lines (2014) (0)
- Remembering Beth Levine - the autophagy pioneer and woman extraordinaire. (2020) (0)
- Chaperone-mediated autophagy: mechanisms and physiological relevance (2022) (0)
- Sa1689 Microtubule Based Motility of Autophagic and Lysosomal Compartments In Vitro: Vesicles With LC3 on Their Surface Show Greater Motility Than Those That Contain Lamp1 (2014) (0)
- Abstract 117: Regulation of Cardiac Mitochondrial Function by Chaperone Mediated Autophagy (2018) (0)
- Aging Cell manuscripts on the road to PubMed Central: shifting from manual to automatic transmission (2008) (0)
- Role of Multiple Factors in Susceptibility of Neurons in Parkinson's Disease (2013) (0)
- From misfolding to autophagy and disease (2015) (0)
- Crystal structure of T7 bacteriophage portal protein, 12mer, closed valve (2019) (0)
- Store-operated Ca 2 + entry ( SOCE ) regulates lipid metabolism (2017) (0)
- Correction: Proteome-wide analysis of chaperone-mediated autophagy targeting motifs (2022) (0)
- Cryo-EM structure of T7 bacteriophage fiberless tail complex (2019) (0)
- Examining an endogenous modulator of chaperone‐mediated autophagy in neurons across Braak stages of Alzheimer's disease (2022) (0)
- Apoptosis: Autophagy – The Liaison between the Lysosomal System and Cell Death (2011) (0)
- Macroautophagy—a novel (cid:1) -amyloid peptide-generating pathway activated in Alzheimer’s disease (2005) (0)
- amyotrophic lateral sclerosis by increasing autophagy XBP-1 deficiency in the nervous system protects against Material Supplemental (2009) (0)
- Lysosomal targeting and degradation of annexins (2000) (0)
- DEPARTMENT OF DEVELOPMENTAL AND MOLECULAR BIOLOGY (2016) (0)
- Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD (2018) (0)
- Chaperone-Mediated Autophagy Ensures Hematopoietic Stem Cell Maintenance (2019) (0)
- Autophagy disregulation in the retina during aging and neurodegeneration (2013) (0)
- The Hallmarks of Aging: Leveraging on Their Interactions (2021) (0)
- Cryo-EM structure of T7 bacteriophage portal protein, 12mer, open valve (2019) (0)
- SELECTIVE AUTOPHAGY: CAN WE TARGET IT TO EXTEND HEALTH-SPAN? (2018) (0)
- Aging Cell in 2012. Editorial. (2013) (0)
- TAU-MEDIATED CELL DEATH MECHANISMS IN MAPT V337M IPSC-DERIVED HUMAN NEURONS (2019) (0)
- P1-163 Autophagic vacuoles contain high beta and gamma secretase activities (2004) (0)
- Aging Cell Prize for Best Paper 2010 (2011) (0)
- Title Cystinosin , the small GTPase Rab 11 , and the Rab 7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP 2 A Permalink (2017) (0)
- 830 Bi-phasic Profile of MnSOD During Tumor Progression in Prostate Cancer (2012) (0)
- Ana Maria Cuervo: Breaking Down Autophagy. (2016) (0)
- Faculty Opinions recommendation of Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker. (2019) (0)
- Autophagy and aging keeping organelles and the proteome healthy (2012) (0)
- Bacteriophage T7 prohead shell EM-derived atomic model (2010) (0)
- Faculty of 1000 evaluation for Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. (2018) (0)
- Selective Autophagy in the Pathogenesis of Parkinson's Disease (2008) (0)
- Phage T7 empty mature head shell (2010) (0)
- Activation Metabolism during Effector T Cell Macroautophagy Regulates Energy (0)
- Selective Autophagy: A Link Across the Hallmarks of Aging (2021) (0)
- Clinical Report Disulfiram Treatment Normalizes Body Weight in Obese Mice (2020) (0)
- Crystal structure of T7 bacteriophage portal protein, 13mer, closed valve (2019) (0)
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