Anant Parekh
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Physiologist
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Anant Parekhbiology Degrees
Biology
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#12735
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Physiology
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#606
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Biology
Anant Parekh's Degrees
- PhD Physiology University of California, San Francisco
- Masters Biology Stanford University
- Bachelors Biochemistry University of California, Berkeley
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Why Is Anant Parekh Influential?
(Suggest an Edit or Addition)According to Wikipedia, Anant B. Parekh is professor of Physiology at the University of Oxford and a Fellow of Merton College, Oxford. Education Parekh was a student at Hymers College and University College, Oxford. He was awarded a Doctor of Philosophy degree by the University of Oxford in 1991 for research on smooth muscle supervised by Alison Brading. He carried out postdoctoral research at the Max Planck Institute for biophysical Chemistry in the laboratory of Nobel Laureate Erwin Neher, working with Walter Stuehmer and then Reinhold Penner.
Anant Parekh's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Store-operated calcium channels. (2005) (2374)
- Store depletion and calcium influx. (1997) (1492)
- Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger (1993) (341)
- Store-operated CRAC channels: function in health and disease (2010) (307)
- The Store-Operated Calcium Current ICRAC: Nonlinear Activation by InsP3 and Dissociation from Calcium Release (1997) (243)
- Respiring mitochondria determine the pattern of activation and inactivation of the store‐operated Ca2+ current ICRAC (2000) (231)
- Decoding cytosolic Ca2+ oscillations. (2011) (222)
- Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function (2008) (220)
- Store‐operated Ca2+ entry depends on mitochondrial Ca2+ uptake (2002) (202)
- Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells. (1995) (169)
- Store-operated Ca2+ entry: dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane. (2003) (164)
- An examination of the secretion‐like coupling model for the activation of the Ca2+ release‐activated Ca2+ current ICRAC in RBL‐1 cells (2001) (151)
- The Wellcome Prize Lecture (2003) (137)
- Decoding of Cytoplasmic Ca2+ Oscillations through the Spatial Signature Drives Gene Expression (2009) (137)
- Biphasic Regulation of Mitochondrial Ca2+ Uptake by Cytosolic Ca2+ Concentration (2006) (119)
- Energized mitochondria increase the dynamic range over which inositol 1,4,5‐trisphosphate activates store‐operated calcium influx (2001) (116)
- Selective Activation of the Transcription Factor NFAT1 by Calcium Microdomains near Ca2+ Release-activated Ca2+ (CRAC) Channels* (2011) (115)
- Distinct Spatial Ca2+ Signatures Selectively Activate Different NFAT Transcription Factor Isoforms (2015) (110)
- Slow Feedback Inhibition of Calcium Release-activated Calcium Current by Calcium Entry* (1998) (104)
- Sustained Activation of the Tyrosine Kinase Syk by Antigen in Mast Cells Requires Local Ca2+ Influx through Ca2+ Release-activated Ca2+ Channels* (2008) (102)
- Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca2+ oscillations and gene expression (2012) (102)
- Ca2+ influx through CRAC channels activates cytosolic phospholipase A2, leukotriene C4 secretion, and expression of c‐fos through ERK‐dependent and independent pathways in mast cells (2006) (102)
- Mitofusin 2 Regulates STIM1 Migration from the Ca2+ Store to the Plasma Membrane in Cells with Depolarized Mitochondria* (2011) (100)
- Potassium channel blockers and the effects of cromakalim on the smooth muscle of the guinea‐pig bladder (1990) (99)
- Fast Calcium-Dependent Inactivation of Calcium Release-Activated Calcium Current (CRAC) in RBL-1 Cells (1999) (96)
- Mitochondrial regulation of store-operated CRAC channels. (2008) (96)
- Mitochondrial regulation of intracellular Ca2+ signaling: more than just simple Ca2+ buffers. (2003) (90)
- Dynamic Assembly of a Membrane Signaling Complex Enables Selective Activation of NFAT by Orai1 (2014) (89)
- Monovalent cation permeability and Ca2+ block of the store-operated Ca2+ current ICRAC in rat basophilic leukemia cells (2002) (87)
- Close Functional Coupling between Ca2+ Release-activated Ca2+ Channels, Arachidonic Acid Release, and Leukotriene C4 Secretion* (2004) (82)
- Local Ca2+ Influx through Ca2+ Release-activated Ca2+ (CRAC) Channels Stimulates Production of an Intracellular Messenger and an Intercellular Pro-inflammatory Signal* (2008) (82)
- Mitochondrial Calcium Uniporter MCU Supports Cytoplasmic Ca2+ Oscillations, Store-Operated Ca2+ Entry and Ca2+-Dependent Gene Expression in Response to Receptor Stimulation (2014) (79)
- CRAC channels and Ca2+ signaling in mast cells (2009) (79)
- CRAC Channels Drive Digital Activation and Provide Analog Control and Synergy to Ca2+-Dependent Gene Regulation (2012) (72)
- Substantial depletion of the intracellular Ca2+ stores is required for macroscopic activation of the Ca2+ release‐activated Ca2+ current in rat basophilic leukaemia cells (2000) (64)
- Calcium dependence and distribution of calcium‐activated chloride channels in Xenopus oocytes (1997) (60)
- On the activation mechanism of store-operated calcium channels (2006) (52)
- Abnormal Intracellular Calcium Homeostasis in Sympathetic Neurons From Young Prehypertensive Rats (2012) (51)
- Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria (2018) (51)
- Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals (2016) (50)
- Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger. (2000) (49)
- Functional consequences of activating store-operated CRAC channels. (2007) (49)
- Coupling of Ca2+ Microdomains to Spatially and Temporally Distinct Cellular Responses by the Tyrosine Kinase Syk* (2009) (49)
- Permeation through store-operated CRAC channels in divalent-free solution: potential problems and implications for putative CRAC channel genes. (2002) (45)
- Targeting Ca2+ release-activated Ca2+ channel channels and leukotriene receptors provides a novel combination strategy for treating nasal polyposis. (2009) (45)
- Mast cell CRAC channel as a novel therapeutic target in allergy (2011) (42)
- On the characterisation of the mechanism underlying passive activation of the Ca2+ release‐activated Ca2+ current ICRAC in rat basophilic leukaemia cells (1999) (42)
- Ca2+ oscillations and Ca2+ influx in Xenopus oocytes expressing a novel 5‐hydroxytryptamine receptor. (1993) (42)
- Ca2+-Calmodulin-dependent Facilitation and Ca2+ Inactivation of Ca2+ Release-activated Ca2+ Channels* (2005) (41)
- Ca2+-Dependent Inactivation of the Mitochondrial Ca2+ Uniporter Involves Proton Flux through the ATP Synthase (2008) (40)
- Activation of store‐operated calcium influx at resting InsP3 levels by sensitization of the InsP3 receptor in rat basophilic leukaemia cells. (1995) (39)
- Ca2+ store dynamics determines the pattern of activation of the store‐operated Ca2+ current ICRAC in response to InsP3 in rat basophilic leukaemia cells (2000) (38)
- Regulation of Store-Operated Calcium Channels by the Intermediary Metabolite Pyruvic Acid (2007) (38)
- Spatial Ca2+ profiling: decrypting the universal cytosolic Ca2+ oscillation (2017) (35)
- Intercellular Ca2+ wave propagation involving positive feedback between CRAC channels and cysteinyl leukotrienes (2009) (34)
- Cell biology: Cracking the calcium entry code (2006) (33)
- Ca2+ Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca2+-Dependent Nuclear Gene Expression (2015) (32)
- Distinct Structural Domains of Caveolin-1 Independently Regulate Ca2+ Release-Activated Ca2+ Channels and Ca2+ Microdomain-Dependent Gene Expression (2015) (32)
- Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression (2011) (31)
- Endoplasmic reticulum–mitochondria coupling: local Ca2+ signalling with functional consequences (2012) (29)
- Regulation of CRAC channels by Ca2+-dependent inactivation. (2017) (29)
- Key Role for Store-Operated Ca2+ Channels in Activating Gene Expression in Human Airway Bronchial Epithelial Cells (2014) (27)
- Effects of inhibitors of the lipo‐oxygenase family of enzymes on the store‐operated calcium current ICRAC in rat basophilic leukaemia cells (2002) (27)
- The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca2+ entry (2021) (27)
- Mitochondrial regulation of CRAC channel-driven cellular responses. (2012) (25)
- Comparison of the activation of the Ca2+ release-activated Ca2+ current ICRAC to InsP3 in Jurkat T-lymphocytes, pulmonary artery endothelia and RBL-1 cells (2000) (24)
- Ca2+-dependent capacitance increases in rat basophilic leukemia cells following activation of store-operated Ca2+ entry and dialysis with high-Ca2+-containing intracellular solution (1998) (24)
- The sources of calcium for carbachol‐induced contraction in the circular smooth muscle of guinea‐pig stomach (1991) (24)
- All-or-None Activation of CRAC Channels by Agonist Elicits Graded Responses in Populations of Mast Cells1 (2007) (24)
- The structure and function of Na+ channels (1992) (24)
- Voltage-dependent Ba2+ permeation through store-operated CRAC channels: implications for channel selectivity. (2007) (22)
- Store‐operated channels: mechanisms and function (2008) (20)
- Ca(2+) signalling and gene regulation. (2011) (20)
- The Allergen Der p3 from House Dust Mite Stimulates Store-Operated Ca2+ Channels and Mast Cell Migration through PAR4 Receptors. (2018) (18)
- Local Ca2+ influx through CRAC channels activates temporally and spatially distinct cellular responses (2009) (17)
- Store-Operated Ca2+ Channels: Mechanism, Function, Pharmacology, and Therapeutic Targets. (2020) (17)
- Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters (2019) (17)
- Regulation of store-operated calcium currents in mast cells. (1996) (17)
- Voltage‐dependent conductance changes in the store‐operated Ca2+ current ICRAC in rat basophilic leukaemia cells (2000) (16)
- Sarcoplasmic/endoplasmic-reticulum-Ca2+-ATPase-mediated Ca2+ reuptake, and not Ins(1,4,5)P3 receptor inactivation, prevents the activation of macroscopic Ca2+ release-activated Ca2+ current in the presence of physiological Ca2+ buffer in rat basophilic leukaemia-1 cells. (2001) (16)
- Calcium Signalling: Mitofusins Promote Interorganellar Crosstalk (2009) (16)
- Comparison of the activation of the Ca (2000) (16)
- Caveolin-1 Alters the Pattern of Cytoplasmic Ca2+ Oscillations and Ca2+-dependent Gene Expression by Enhancing Leukotriene Receptor Desensitization* (2014) (14)
- Activation of the store‐operated calcium current ICRAC can be dissociated from regulated exocytosis in rat basophilic leukaemia (RBL‐1) cells (2003) (14)
- STIM proteins, Orai1, and gene expression (2013) (14)
- Adenophostin A and ribophostin, but not inositol 1,4,5-trisphosphate or manno-adenophostin, activate the Ca2+ release-activated Ca2+ current, I(CRAC), in weak intracellular Ca2+ buffer. (2002) (14)
- Nonhydrolyzable Analogues of GTP Activate a New Na+ Current in a Rat Mast Cell Line* (1996) (13)
- The M3 muscarinic receptor links to three different transduction mechanisms with different efficacies in circular muscle of guinea‐pig stomach (1992) (13)
- Single-nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression (2019) (12)
- Ca2+ Influx through Store-operated Calcium Channels Replenishes the Functional Phosphatidylinositol 4,5-Bisphosphate Pool Used by Cysteinyl Leukotriene Type I Receptors* (2015) (12)
- Effects of phosphatidylinositol kinase inhibitors on the activation of the store-operated calcium current ICRAC in RBL-1 cells (2001) (12)
- Signaling through Ca2+ Microdomains from Store-Operated CRAC Channels. (2020) (12)
- The whole‐cell Ca2+ release‐activated Ca2+ current, I CRAC, is regulated by the mitochondrial Ca2+ uniporter channel and is independent of extracellular and cytosolic Na+ (2019) (12)
- The effects of interfering with GTP-binding proteins on the activation mechanism of calcium release-activated calcium current (1999) (11)
- A CRAC current tango (2006) (10)
- Regulation of Store-Operated Calcium Channels by the Intermediary Metabolite Pyruvic Acid (2007) (9)
- Receptors involved in mechanical responses to catecholamines in the circular muscle of guinea‐pig stomach treated with meclofenamate (1990) (9)
- Studies of longitudinal tissue impedance in various smooth muscles. (1990) (8)
- through the Spatial Signature Drives Gene Expression (2009) (8)
- Store-operated Ca2+ channels in airway epithelial cell function and implications for asthma (2016) (8)
- AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels (2021) (8)
- Inwardly rectifying potassium currents in rat basophilic leukaemia (RBL-1) cells: regulation by spermine and implications for store-operated calcium influx (2002) (8)
- Interaction between capacitative Ca2+ influx and Ca2+-dependent Cl− currents inXenopus oocytes (1995) (7)
- An examination of the role of intracellular ATP in the activation of store-operated Ca2+ influx and Ca2+-dependent capacitance increases in rat basophilic leukaemia cells (1998) (7)
- Interaction between capacitative Ca2+ influx and Ca2+-dependent Cl- currents in Xenopus oocytes. (1995) (7)
- Ca 2-Calmodulin-dependent Facilitation and Ca 2 Inactivation of Ca 2 Release-activated Ca 2 Channels * (2005) (6)
- Calcium signalling in health and disease. (2019) (6)
- New insights into Ca2+ channel function in health and disease (2017) (4)
- Depletion-activated Ca current is inactivated by protein kinase C (1995) (4)
- Mitofusin 2 Regulates STIM1 Migration from the Ca 2 Store to the Plasma Membrane in Cells with Depolarized (2011) (4)
- Endoplasmic reticulum–mitochondria coupling: local Ca2+ signalling with functional consequences (2012) (4)
- Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation (2020) (3)
- Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation. (2021) (2)
- Arf-1 (ADP-ribosylation factor-1) is involved in the activation of a mammalian Na+-selective current. (2004) (2)
- Intracellular Ca2+ signaling: calcium influx (2007) (2)
- Voltage-dependent Conductance Changes in a Nonvoltage-activated Sodium Current from a Mast Cell Line (1998) (2)
- Plasma membrane Ca2+ ATPase activity enables sustained store-operated Ca2+ entry in the absence of a bulk cytosolic Ca2+ rise (2022) (2)
- Mechanical responses to catecholamines in the longitudinal muscle of guinea‐pig gastric fundus (1991) (2)
- Sequi Ad Maius Bonum; Targeting Ion Channels in the Lung. (2020) (1)
- Neuronal Ca2+ signalling: pathways and targets (2001) (1)
- Electrophysiological Recordings of Ca2+ Currents (2005) (1)
- Signalling mechanisms stimulus-secretion coupling in the nervous system (1993) (1)
- Advances in intracellular Ca2+ signalling (2016) (1)
- Effects of protein phosphorylation on the regulation of capacitative calcium influx in xenopus oocytes (1996) (1)
- Depletion-activated calcium current is inhibited by protein kinase in RBL-2 H 3 cells ( Ca 2 + release-activated Ca 2 + current / protein kinase / fura-2 / patch clamp ) (2005) (1)
- Ion channels in patho‐physiology (2012) (1)
- Faculty Opinions recommendation of MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+. (2018) (0)
- Opening New Terrain in Intracellular Ca2+ Signaling. (2021) (0)
- Cytosolic and intra-organellar Ca2+ oscillations: mechanisms and function (2020) (0)
- Probing the activation mechanism of the store-operated Ca2+ current ICRAC (2004) (0)
- Faculty of 1000 evaluation for A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity. (2018) (0)
- Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria (2018) (0)
- Faculty Opinions recommendation of Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism. (2019) (0)
- "Study the Past if You Would Define the Future."-Confucius. (2023) (0)
- Alison F. Brading (1939–2011) (2011) (0)
- Respiring mitochondria are required for macroscopic activation of I-CRAC following receptor stimulation (2002) (0)
- Evidence of absence with a twist: voltage-operated Ca2+ channel β subunit in T cells. (2022) (0)
- Faculty Opinions recommendation of TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation. (2020) (0)
- Regulation of the store-operated calcium current I-CRAC: dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane (2002) (0)
- Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters (2019) (0)
- Faculty Opinions recommendation of Krüppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death. (2016) (0)
- Faculty Opinions recommendation of Flavored E-liquids Increase Cytoplasmic Ca2+ Levels in Airway Epithelia. (2019) (0)
- Whole cell patch clamp recordings demonstrate the presence of CRAC channels. (2014) (0)
- The structure and function of Na+ channels (1992) (0)
- Distinct Structural Domains of Caveolin-1 Independently Regulate Ca 2 (cid:2) Release-Activated Ca 2 (cid:2) Channels and Ca 2 (cid:2) Microdomain-Dependent Gene Expression (2015) (0)
- An introduction to the Bioscience Birthday Symposium held in honour of Ole Petersen CBE, FRS (2014) (0)
- Faculty Opinions recommendation of The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration. (2021) (0)
- Receptor-mediated stimulation of I-CRAC: Role for mitochondria. (2002) (0)
- CA-2+ release and CA-2+ influx in xenopus oocytes following expression of a 5-hydroxytryptamine receptor. (1993) (0)
- Nuanced Interactions between AKAP79 and STIM1 with Orai1 Ca2+ Channels at Endoplasmic Reticulum-Plasma Membrane Junctions Sustain NFAT Activation (2022) (0)
- Involvement of phosphatases in receptor driven pool depletion activated CA2+ influx in xenopus-oocytes (1994) (0)
- Faculty of 1000 evaluation for Cross-linking of Orai1 channels by STIM proteins. (2018) (0)
- FUNCTIONAL CONSEQUENCES OF CRAC CHANNEL ACTIVATION IN HEALTH AND DISEASE (2009) (0)
- Regulation of CRAC channels and agonist-induced Ca2+ signals (2012) (0)
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