Andrea Mari

Q: What Schools Are Affiliated With Andrea Mari

Andrea Mari is affiliated with the following schools: Consorzio ICoN, University of Texas Health Science Center at San Antonio, University of Padua, University of Toronto

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Andrea Mari

Engineering

#6644

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#7980

Historical Rank

Bioengineering

#71

World Rank

#73

Historical Rank

Biomedical Engineering

#606

World Rank

#616

Historical Rank

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Engineering

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Andrea Mari's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. (2014) (825)
A Model-Based Method for Assessing Insulin Sensitivity From the Oral Glucose Tolerance Test (2001) (606)
How to measure insulin sensitivity (1998) (528)
beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. (2005) (491)
Shift to Fatty Substrate Utilization in Response to Sodium–Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes (2016) (439)
Separate Impact of Obesity and Glucose Tolerance on the Incretin Effect in Normal Subjects and Type 2 Diabetic Patients (2008) (388)
Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes. (2005) (375)
Mechanisms of Recovery From Type 2 Diabetes After Malabsorptive Bariatric Surgery (2006) (355)
Meal and oral glucose tests for assessment of beta -cell function: modeling analysis in normal subjects. (2002) (296)
Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance (2013) (295)
Common Variants of the Novel Type 2 Diabetes Genes CDKAL1 and HHEX/IDE Are Associated With Decreased Pancreatic β-Cell Function (2007) (255)
Visceral Fat in Hypertension: Influence on Insulin Resistance and β-Cell Function (2004) (250)
The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients. (2007) (244)
Roux-en-Y gastric bypass and sleeve gastrectomy: mechanisms of diabetes remission and role of gut hormones. (2013) (243)
Assessing insulin secretion by modeling in multiple-meal tests: role of potentiation. (2002) (239)
Beta cell function and its relation to insulin action in humans: a critical appraisal (2004) (236)
Methods for clinical assessment of insulin sensitivity and β-cell function (2003) (231)
Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes (2011) (197)
The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and Objectives (2004) (180)
Free fatty acids impair hepatic insulin extraction in vivo. (1999) (180)
Insulin resistance, insulin response, and obesity as indicators of metabolic risk. (2007) (176)
A Model-Based Method for Assessing Insulin Sensitivity From the Oral Glucose Tolerance Test. Diabetes Care 2001;24:539–548 (2014) (169)
Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients. (1999) (169)
Methods for clinical assessment of insulin sensitivity and beta-cell function. (2003) (167)
The role of beta-cell function and insulin sensitivity in the remission of type 2 diabetes after gastric bypass surgery. (2011) (165)
Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans. (2011) (163)
A Central Role for GRB10 in Regulation of Islet Function in Man (2014) (159)
Acute and 2-week exposure to prednisolone impair different aspects of beta-cell function in healthy men. (2010) (154)
Non-steady state: error analysis of Steele's model and developments for glucose kinetics. (1987) (152)
beta-cell function in obesity: effects of weight loss. (2004) (136)
Dapagliflozin lowers plasma glucose concentration and improves β-cell function. (2015) (135)
Thiazolidinediones improve beta-cell function in type 2 diabetic patients. (2007) (132)
Efficacy and tolerability of vildagliptin in drug‐naïve patients with type 2 diabetes and mild hyperglycaemia * (2008) (126)
Evidence that vildagliptin attenuates deterioration of glycaemic control during 2‐year treatment of patients with type 2 diabetes and mild hyperglycaemia * (2008) (122)
Metabolic Effects of Chronic Cannabis Smoking (2013) (122)
Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance. (2009) (117)
Liver Enzymes Are Associated With Hepatic Insulin Resistance, Insulin Secretion, and Glucagon Concentration in Healthy Men and Women (2011) (117)
Restoration of normal glucose tolerance in severely obese patients after bilio-pancreatic diversion: role of insulin sensitivity and beta cell function (2006) (117)
Progression to Diabetes in Relatives of Type 1 Diabetic Patients: Mechanisms and Mode of Onset (2009) (116)
Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance (2003) (115)
Dose-response characteristics of insulin action on glucose metabolism: a non-steady-state approach. (2000) (109)
Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance (2010) (106)
β-Cell function in type 2 diabetes. (2014) (105)
beta-cell function in morbidly obese subjects during free living: long-term effects of weight loss. (2005) (102)
Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes (2014) (101)
Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes. (2012) (99)
Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance (2012) (98)
Within-subject variability of measures of beta cell function derived from a 2 h OGTT: implications for research studies (2007) (98)
Estimation of the rate of appearance in the non-steady state with a two-compartment model. (1992) (98)
Preeclampsia in Lean Normotensive Normotolerant Pregnant Women Can Be Predicted by Simple Insulin Sensitivity Indexes (2006) (97)
Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test (2005) (97)
Characterization of the influence of vildagliptin on model-assessed -cell function in patients with type 2 diabetes and mild hyperglycemia. (2008) (97)
β‐cell function assessment from modelling of oral tests: an effective approach (2008) (94)
Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training (2007) (94)
Long-Term Effects of Bariatric Surgery on Meal Disposal and β-Cell Function in Diabetic and Nondiabetic Patients (2013) (90)
Validation of mathematical models of complex endocrine-metabolic systems. A case study on a model of glucose regulation (1983) (90)
Effect of acute hyperglycemia on insulin secretion in humans. (2002) (90)
Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions. (2007) (89)
Sclerostin and Insulin Resistance in Prediabetes: Evidence of a Cross Talk Between Bone and Glucose Metabolism (2015) (88)
Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance. (2006) (86)
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants (2017) (85)
Thiazolidinediones improve -cell function in type 2 diabetic patients (2007) (85)
Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients. (2014) (84)
Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response (2009) (83)
Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. (2011) (82)
Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial (2018) (79)
Characterization of GLP-1 effects on beta-cell function after meal ingestion in humans. (2003) (77)
Improved tolerance to sequential glucose loading (Staub-Traugott effect): size and mechanisms. (2009) (75)
GLP-1 and Glucose Tolerance After Sleeve Gastrectomy in Morbidly Obese Subjects With Type 2 Diabetes (2014) (75)
Assessment of insulin secretion in relation to insulin resistance (2005) (74)
The effects of bariatric surgery on pancreatic lipid metabolism and blood flow. (2015) (74)
Moderate alcohol consumption is associated with improved insulin sensitivity, reduced basal insulin secretion rate and lower fasting glucagon concentration in healthy women (2012) (73)
Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study (2011) (73)
Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men. (2009) (71)
Identification, pathophysiology, and clinical implications of primary insulin hypersecretion in nondiabetic adults and adolescents. (2018) (71)
Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea. (2006) (69)
β-Cell Function, Incretin Effect, and Incretin Hormones in Obese Youth Along the Span of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes (2014) (68)
Mathematical modeling in glucose metabolism and insulin secretion (2002) (68)
Effects of meal size and composition on incretin, alpha-cell, and beta-cell responses. (2010) (66)
Postdinner resistance exercise improves postprandial risk factors more effectively than predinner resistance exercise in patients with type 2 diabetes. (2015) (63)
Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort. (2009) (62)
A model for glucose control of insulin secretion during 24 h of free living. (2001) (61)
Biliopancreatic diversion in nonobese patients with type 2 diabetes: impact and mechanisms. (2013) (60)
Glucokinase links Krüppel‐like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease (2012) (60)
Early detection of insulin sensitivity and beta-cell function with simple tests indicates future derangements in late pregnancy. (2008) (59)
Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes (2008) (58)
Imeglimin increases glucose‐dependent insulin secretion and improves β‐cell function in patients with type 2 diabetes (2015) (58)
Effect of Pioglitazone on the Metabolic and Hormonal Response to a Mixed Meal in Type II Diabetes (2007) (56)
Improvement in Insulin Sensitivity and Β-Cell Function Following Ileal Interposition with Sleeve Gastrectomy in Type 2 Diabetic Patients: Potential Mechanisms (2011) (55)
Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp. (2013) (53)
Glucose absorption and production following oral glucose: comparison of compartmental and arteriovenous-difference methods. (1994) (52)
Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT. (2013) (51)
Visceral fat and beta cell function in non-diabetic humans (2005) (51)
Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles (2008) (50)
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium (2014) (49)
Assessment of insulin sensitivity and secretion with the labelled intravenous glucose tolerance test: improved modelling analysis (1998) (49)
A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models (2003) (48)
Beta-cell function in severely obese type 2 diabetic patients: long-term effects of bariatric surgery. (2007) (47)
Lipid-induced β-cell dysfunction in vivo in models of progressive β-cell failure (2007) (45)
Identification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients. (2011) (44)
Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency. (2012) (44)
Mechanisms of hyperinsulinaemia in Child’s disease grade B liver cirrhosis investigated in free living conditions (2002) (44)
Altered pattern of the incretin effect as assessed by modelling in individuals with glucose tolerance ranging from normal to diabetic (2014) (43)
Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor (2008) (43)
Mechanisms through which a small protein and lipid preload improves glucose tolerance (2015) (42)
Progression to Type 2 Diabetes in Women with Former Gestational Diabetes: Time Trajectories of Metabolic Parameters (2012) (42)
Influence of Hyperinsulinemia and Insulin Resistance on In Vivo β-Cell Function (2011) (42)
Effects of portal free fatty acid elevation on insulin clearance and hepatic glucose flux. (2006) (40)
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts (2020) (40)
Control of Diabetes with Artificial Systems for Insulin Delivery Algorithm Independent Limitations Revealed by a Modeling Study (1985) (39)
Potentiation of the early-phase insulin response by a prior meal contributes to the second-meal phenomenon in type 2 diabetes. (2011) (38)
Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic β-cell dysfunction. (2012) (37)
m.3243A>G Mutation in Mitochondrial DNA Leads to Decreased Insulin Sensitivity in Skeletal Muscle and to Progressive β-Cell Dysfunction (2009) (37)
Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects (2005) (37)
Mechanisms of the Incretin Effect in Subjects with Normal Glucose Tolerance and Patients with Type 2 Diabetes (2013) (36)
Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial. (2014) (36)
Impaired glucose absorption in children with severe malnutrition. (2011) (35)
Reconstructing the rate of appearance of subcutaneous insulin by deconvolution. (1987) (35)
The effect of alogliptin and pioglitazone combination therapy on various aspects of β-cell function in patients with recent-onset type 2 diabetes. (2014) (34)
Assessment of insulin sensitivity with minimal model: role of model assumptions. (1997) (34)
Discriminatory ability of simple OGTT-based beta cell function indices for prediction of prediabetes and type 2 diabetes: the CODAM study (2016) (33)
Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion (2013) (33)
Coronary microcirculatory vasoconstriction is heterogeneously distributed in acutely ischemic myocardium. (2005) (33)
Plasma HDL-cholesterol and triglycerides, but not LDL-cholesterol, are associated with insulin secretion in non-diabetic subjects. (2017) (33)
Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure. (2007) (32)
Effects of subcutaneous tirzepatide versus placebo or semaglutide on pancreatic islet function and insulin sensitivity in adults with type 2 diabetes: a multicentre, randomised, double-blind, parallel-arm, phase 1 clinical trial. (2022) (32)
Circulatory models of intact-body kinetics and their relationship with compartmental and non-compartmental analysis. (1993) (31)
Impaired β‐cell function in lean normotolerant former gestational diabetic women (2006) (31)
Incretin and islet hormone responses to meals of increasing size in healthy subjects. (2015) (30)
Glucose‐lowering effect of the DPP‐4 inhibitor sitagliptin after glucose and non‐glucose macronutrient ingestion in non‐diabetic subjects (2013) (30)
β-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans. (2016) (30)
Effect of Dapagliflozin With and Without Acipimox on Insulin Sensitivity and Insulin Secretion in T2DM Males. (2016) (29)
Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance? (2013) (29)
Improvement in β-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes. (2012) (29)
Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men (2009) (28)
Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. (2021) (28)
A Circulatory Model for the Estimation of Insulin Sensitivity (1997) (28)
The Association Between Sleep Duration, Insulin Sensitivity, and β-Cell Function: The EGIR-RISC Study. (2016) (27)
Hepatic fat is not associated with beta-cell function or postprandial free fatty acid response. (2009) (26)
Beta-cell function in mild type 2 diabetic patients: effects of 6-month glucose lowering with nateglinide. (2005) (26)
Postprandial metabolic responses to mixed versus liquid meal tests in healthy men and men with type 2 diabetes. (2011) (26)
Risk Factors for Spontaneously Self-Reported Postprandial Hypoglycemia After Bariatric Surgery. (2016) (26)
Characterization of beta-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests. (2005) (26)
Reduced insulin clearance and insulin degrading enzyme activity contribute to hyperinsulinemia in African Americans. (2020) (26)
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium (2019) (26)
Increased β-Cell Workload Modulates Proinsulin-to-Insulin Ratio in Humans (2018) (25)
Influence of endogenous NEFA on beta cell function in humans (2015) (25)
Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance. (2010) (25)
Circulating palmitoleic acid is an independent determinant of insulin sensitivity, beta cell function and glucose tolerance in non-diabetic individuals: a longitudinal analysis (2019) (24)
Effects of Leptin Replacement Therapy on Pancreatic β-Cell Function in Patients With Lipodystrophy (2014) (23)
Mixed meal ingestion diminishes glucose excursion in comparison with glucose ingestion via several adaptive mechanisms in people with and without type 2 diabetes (2016) (23)
Exenatide improves β-cell function up to 3 years of treatment in patients with type 2 diabetes: a randomised controlled trial. (2016) (23)
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study (2022) (22)
One‐hour post‐load plasma glucose predicts progression to prediabetes in a multi‐ethnic cohort of obese youths (2019) (22)
Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion (2015) (22)
Metabolic consequences of acute and chronic empagliflozin administration in treatment-naive and metformin pretreated patients with type 2 diabetes (2016) (21)
Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes (T2DM) and mild hyperglycemia (2008) (21)
Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects (2006) (21)
Defective Amplifying Pathway of β-Cell Secretory Response to Glucose in Type 2 Diabetes: Integrated Modeling of In Vitro and In Vivo Evidence (2017) (20)
The insulinotropic effect of a high-protein nutrient preload is mediated by the increase of plasma amino acids in type 2 diabetes (2018) (20)
Impaired beta-cell function in lean normotolerant former gestational diabetic women. (2006) (20)
Determination of the single-pass impulse response of the body tissues with circulatory models (1995) (20)
Inhibition of sweet chemosensory receptors alters insulin responses during glucose ingestion in healthy adults: a randomized crossover interventional study. (2017) (20)
Lifetime congenital isolated GH deficiency does not protect from the development of diabetes (2013) (20)
The potential role of the osteopontin–osteocalcin–osteoprotegerin triad in the pathogenesis of prediabetes in humans (2017) (19)
Intrahepatic fat, irrespective of ethnicity, is associated with reduced endogenous insulin clearance and hepatic insulin resistance in obese youths: a cross-sectional and longitudinal study from the Yale Pediatric NAFLD cohort. (2020) (19)
Sustained effects of a protein and lipid preload on glucose tolerance in type 2 diabetes patients. (2016) (19)
Effects of meal and incretins in the regulation of splanchnic blood flow (2017) (19)
Metformin increases fasting glucose clearance and endogenous glucose production in non-diabetic individuals (2019) (19)
Associations between sleep duration and sleep debt with insulin sensitivity and insulin secretion in the EGIR-RISC Study. (2019) (18)
Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models. (2012) (18)
Measurement of postprandial glucose fluxes in response to acute and chronic endurance exercise in healthy humans. (2018) (18)
Value of the intravenous and oral glucose tolerance tests for detecting subtle impairments in insulin sensitivity and beta‐cell function in former gestational diabetes (2008) (18)
Lack of association of liver fat with model parameters of beta-cell function in men with impaired glucose tolerance and type 2 diabetes. (2008) (17)
Differences in β‐cell function and insulin secretion in Black vs. White obese adolescents: do incretin hormones play a role? (2017) (17)
Glucose Metabolism in High-Risk Subjects for Type 2 Diabetes Carrying the rs7903146 TCF7L2 Gene Variant. (2015) (17)
Influence of gestational diabetes on the long-term control of glucose tolerance (2007) (17)
In ﬂ uence of Hyperinsulinemia and Insulin Resistance on In Vivo b -Cell Function Their Role in Human b -Cell Dysfunction (2011) (17)
Effects of Sustained Treatment With Lixisenatide on Gastric Emptying and Postprandial Glucose Metabolism in Type 2 Diabetes: A Randomized Controlled Trial (2020) (16)
Roux‐en‐Y gastric bypass compared with equivalent diet restriction: Mechanistic insights into diabetes remission (2018) (16)
On linearity of insulin kinetics. (1986) (16)
Postprandial hypoglycaemia after Roux-en-Y gastric bypass in individuals with type 2 diabetes (2018) (16)
Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response. (2017) (15)
Mathematical Modeling for the Physiological and Clinical Investigation of Glucose Homeostasis and Diabetes (2020) (15)
Associations of Dietary Glucose, Fructose, and Sucrose with β-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study (2017) (15)
Age- and Sex-Dependent Distribution of OGTT-Related Variables in a Population of Cystic Fibrosis Patients. (2015) (14)
Bariatric Surgery Enhances Splanchnic Vascular Responses in Patients With Type 2 Diabetes (2017) (14)
Effect of exenatide on postprandial glucose fluxes, lipolysis, and ß‐cell function in non‐diabetic, morbidly obese patients (2017) (14)
Clinical evidence for myocardial derecruitment downstream from severe stenosis: pressure-flow control interaction. (2000) (14)
Effects of Low-Carbohydrate versus Mediterranean Diets on Weight Loss, Glucose Metabolism, Insulin Kinetics and β-Cell Function in Morbidly Obese Individuals (2021) (14)
The Finnish Diabetes Risk Score is associated with insulin resistance but not reduced β‐cell function, by classical and model‐based estimates (2011) (14)
The Effect of a Vegetarian vs Conventional Hypocaloric Diabetic Diet on Thigh Adipose Tissue Distribution in Subjects with Type 2 Diabetes: A Randomized Study (2017) (13)
Differential effects of once‐weekly glucagon‐like peptide‐1 receptor agonist dulaglutide and metformin on pancreatic β‐cell and insulin sensitivity during a standardized test meal in patients with type 2 diabetes (2016) (13)
Intestinal Glucose Absorption Is a Key Determinant of 1-Hour Postload Plasma Glucose Levels in Nondiabetic Subjects. (2018) (13)
Body Weight, Not Insulin Sensitivity or Secretion, May Predict Spontaneous Weight Changes in Nondiabetic and Prediabetic Subjects (2011) (12)
Effects of acute NEFA manipulation on incretin-induced insulin secretion in participants with and without type 2 diabetes (2018) (12)
Beta-cell function is associated with carotid intima-media thickness independently of insulin resistance in healthy individuals (2016) (12)
Effect of ovarian suppression with gonadotropin-releasing hormone agonist on glucose disposal and insulin secretion. (2008) (12)
Lumacaftor/ivacaftor in cystic fibrosis: effects on glucose metabolism and insulin secretion (2021) (12)
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
Improved Beta Cell Glucose Sensitivity Plays Predominant Role in the Decrease in HbA1c with Cana and Lira in T2DM. (2020) (11)
Prospective associations of dietary carbohydrate, fat, and protein intake with β-cell function in the CODAM study (2018) (11)
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study (2020) (11)
The heritability of beta cell function parameters in a mixed meal test design (2011) (11)
Effect of single‐dose DPP‐4 inhibitor sitagliptin on β‐cell function and incretin hormone secretion after meal ingestion in healthy volunteers and drug‐naïve, well‐controlled type 2 diabetes subjects (2018) (11)
Triglyceride‐rich very low‐density lipoproteins (VLDL) are independently associated with insulin secretion in a multiethnic cohort of adolescents (2018) (10)
β‐cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults (2020) (10)
Assessment of the Role of Metabolic Determinants on the Relationship between Insulin Sensitivity and Secretion (2016) (10)
Methods for the Assessment of β‐Cell Function In Vivo (2007) (10)
Reducing Cholesterol and Fat Intake Improves Glucose Tolerance by Enhancing &bgr; Cell Function in Nondiabetic Subjects (2018) (10)
On the calculation of glucose rate of disappearance in nonsteady state. (1994) (10)
Assessment of insulin action on glucose uptake and production during a euglycemic-hyperinsulinemic clamp in dog: a new kinetic analysis. (1997) (10)
Liver blood dynamics after bariatric surgery: the effects of mixed-meal test and incretin infusions (2018) (10)
Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study. (2013) (9)
Calculation of organ and whole-body uptake and production with the impulse response approach (1995) (9)
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study (2021) (9)
The amino acid response to a mixed meal in patients with type 2 diabetes: effect of sitagliptin treatment (2014) (9)
A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals (2022) (9)
Increase in endogenous glucose production with SGLT2 inhibition is attenuated in individuals who underwent kidney transplantation and bilateral native nephrectomy (2020) (9)
Adaptation of β-Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance (2015) (9)
Elevated Glucose Oxidation, Reduced Insulin Secretion, and a Fatty Heart May Be Protective Adaptions in Ischemic CAD (2016) (9)
New Insights on the Interactions Between Insulin Clearance and the Main Glucose Homeostasis Mechanisms (2021) (8)
Disruption of fasting and post-load glucose homeostasis are largely independent and sustained by distinct and early major beta-cell function defects: a cross-sectional and longitudinal analysis of the relationship between insulin sensitivity and cardiovascular risk (RISC) study cohort. (2020) (8)
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study (2020) (8)
Glucose uptake saturation explains glucose kinetics profiles measured by different tests. (2016) (8)
Persistent whole day meal effects of three dipeptidyl peptidase‐4 inhibitors on glycaemia and hormonal responses in metformin‐treated type 2 diabetes (2019) (8)
Ventilation inhomogeneity is associated with OGTT‐derived insulin secretory defects in cystic fibrosis (2019) (8)
Pharmacogenomics of GLP-1 Receptor Agonists: A genome-wide analysis of observational data and large randomized controlled trials (2022) (8)
Association of artificially sweetened and sugar-sweetened soft drinks with β-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study (2019) (8)
Fimasartan increases glucose‐stimulated insulin secretion in patients with type 2 diabetes and hypertension compared with amlodipine (2018) (8)
Relationship between whole-body macronutrient oxidative partitioning and pancreatic insulin secretion/β-cell function in non-diabetic humans. (2014) (7)
OPTIMIZED HUMAN REGULAR U-500 INSULIN TREATMENT IMPROVES β-CELL FUNCTION IN SEVERELY INSULIN-RESISTANT PATIENTS WITH LONG-STANDING TYPE 2 DIABETES AND HIGH INSULIN REQUIREMENTS. (2015) (7)
Insulin resistance is central to long-term reversal of histologic non-alcoholic steatohepatitis after metabolic surgery. (2020) (7)
The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans (2021) (7)
GLP-1 response to sequential mixed meals: influence of insulin resistance. (2017) (7)
Brain substrate metabolism and ß‐cell function in humans: A positron emission tomography study (2020) (7)
The effect of a vegetarian versus conventional hypocaloric diet on serum concentrations of persistent organic pollutants in patients with type 2 diabetes. (2016) (7)
β-Cell Function in Severely Obese Type 2 Diabetic Patients (2007) (7)
Assessment of Insulin Sensitivity from Steady‐State and Dynamic Tests (2007) (7)
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study (2020) (6)
One hour post-load plasma glucose and 3 year risk of worsening fasting and 2 hour glucose tolerance in the RISC cohort (2018) (6)
Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes. (2020) (6)
A model for assessing insulin secretion and its control under free-living conditions. (2001) (5)
Noradrenergic fibers are associated with beta-cell dedifferentiation and impaired beta-cell function in humans. (2020) (5)
Normal β‐cell function (2015) (5)
Relationship between glucose volume of distribution and the extracellular space: a multiple tracer study. (2011) (5)
Elevated heart rate predicts β cell function in non-diabetic individuals: the RISC cohort. (2015) (5)
Contribution of defects in insulin sensitivity and beta-cell function to the changes over time in the glucose tolerance of cystic fibrosis patients (2006) (4)
Physical Activity Associates with Muscle Insulin Sensitivity Postbariatric Surgery (2018) (4)
Impact of a mild decrease in fasting plasma glucose on β-cell function in healthy subjects and patients with type 2 diabetes. (2016) (4)
Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study (2020) (4)
Interrelations between electrical and biochemical processes in ischemic porcine livers at low temperature. (1993) (4)
Bile Modulates Secretion of Incretins and Insulin: A Study of Human Extrahepatic Cholestasis. (2019) (4)
Nonalcoholic Fatty Liver Is Not Associated with the Relationship between Insulin Secretion and Insulin Sensitivity in Obese Children: Matched Case-Control Study. (2016) (4)
Pancreaticoduodenectomy model demonstrates a fundamental role of dysfunctional β cells in predicting diabetes (2021) (4)
Separate impact of obesity and glucose tolerance on incretin effect in humans (2007) (3)
Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity (2020) (3)
Syddansk Universitet Association analysis of 29 , 956 individuals confirms that a low-frequency variant at CCND 2 halves the risk of type 2 diabetes by enhancing insulin secretion (2015) (3)
Insulin secretion and impaired glucose tolerance. Reply to Jenkins AB, Campbell LV [letter] (2010) (3)
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium (2018) (3)
Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study. (2021) (3)
A low n‐6 to n‐3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youth (2022) (3)
Methods of Assessment of Insulin Sensitivity and β-Cell Function (2006) (3)
Acute Administration of the GLP-1 Receptor Agonist Lixisenatide Diminishes Postprandial Insulin Secretion in Healthy Subjects But Not in Type 2 Diabetes, Associated with Slowing of Gastric Emptying (2022) (3)
The Role of (cid:1) -Cell Function and Insulin Sensitivity in the Remission of Type 2 Diabetes after Gastric Bypass Surgery (2011) (3)
Short Course of Insulin Treatment versus Metformin in Newly Diagnosed Patients with Type 2 Diabetes (2018) (3)
The Impact of Low-dose Gliclazide on the Incretin Effect and Indices of Beta-cell Function (2021) (3)
Beneficial Effects of RYGB on ß-Cell Function and Hepatic and Peripheral Insulin Sensitivity Are Maintained Seven Years after Surgery in Both Diabetic and Nondiabetic Subjects (2018) (2)
Clinical profiles of post‐load glucose subgroups and their association with glycaemic traits over time: An IMI‐DIRECT study (2020) (2)
Lipid-induced glucose intolerance is driven by impaired glucose kinetics and insulin metabolism in healthy individuals. (2022) (2)
Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models (2023) (2)
Intra-islet insulin synthesis defects are associated with endoplasmic reticulum stress and loss of beta cell identity in human diabetes (2022) (2)
On the estimation of absorption of subcutaneous injected insulin from plasma concentrations using mathematical models (1984) (2)
Phase 2 trial with imeglimin in patients with Type 2 diabetes indicates effects on insulin secretion and sensitivity (2022) (2)
GLUTRAN : a Matlab toolbox for glucose tracer analysis (2009) (2)
Exercise mode influences post‐exercise glucose sensitivity and insulin clearance in young, healthy males and females in a sex‐dependent manner: A randomized control trial (2022) (2)
Comment on ‘Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial’. Reply to Amini P and Moharamzadeh S [letter] (2018) (2)
Duodenopancreatectomy as a model to demonstrate the fundamental role of dysfunctional β cell in predicting diabetes. (2021) (2)
Sleeping oxygen saturation, rapid eye movement sleep, and the adaptation of postprandial metabolic function in insulin sensitive and resistant individuals without diabetes (2018) (1)
Fixed‐ratio combination of insulin glargine plus lixisenatide (iGlarLixi) improves ß‐cell function in people with type 2 diabetes (2022) (1)
Clustering on baseline clinical variables identifies subgroups of type 2 diabetes patients with different rate of progression over 18 months: a DIRECT study (2017) (1)
A reference map of potential determinants for the human serum metabolome (2020) (1)
One-year exenatide treatment improves beta cell response in metformin treated patients with type 2 diabetes which is sustained after 5 weeks discontinuation of treatment (2009) (1)
Association of serum lipids with β-cell function in obese children and adolescents (2019) (1)
Influence of tissue acidification and halothane anesthesia on hepatic electrical and biochemical properties during ischemia. (1991) (1)
The effect of age on longitudinal measures of beta cell function and insulin sensitivity during the progression of early stage type 1 diabetes (2022) (1)
The Impact and Correction of Analysis Delay and Variability in Storage Temperature on the Assessment of HbA1c from Dried Blood Spots-an IMI DIRECT Study (2019) (1)
Relationships between Glucose Clearance during an OGTT and a Euglycemic Clamp (2010) (1)
Loss of the incretin effect in type 2 diabetes: a systematic review and meta-analysis. (2022) (1)
Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes (2022) (1)
Model Analysis of β-Cell Function in First-Degree Relatives of Type 2 Diabetics and Its Relation to Insulin Resistance (2002) (1)
261-OR: Dorzagliatin, a Dual-Acting Glucokinase Activator. Improves Insulin Secretion and Glucose Sensitivity in Glucokinase-Maturity-Onset Diabetes of the Young (GCK-MODY) (2022) (1)
Postprandial GLP-1 Response Is Inversely Associated with Liver Fat (2009) (1)
714-P: Greater Improvement in Insulin Sensitivity Per Unit Weight Loss with Tirzepatide Compared with Selective GLP-1 Receptor Agonism (2022) (1)
Heptanol effects on protected livers. (1990) (1)
Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk (2020) (1)
124-OR: Comparison of OGTT Model-Derived Measures of ß-Cell Function between Youth and Adults (2019) (1)
Abstract: P409 INCRETINS ARE ASSOCIATED WITH POSTPRANDIAL TRIGYCERIDES (2009) (1)
Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study (2020) (1)
Track 7 Diabetes and hyperlipidemia in obesity P205–P259 (2001) (0)
Pathophysiology: Loss of β-Cell Function (2012) (0)
290-OR: Altered In-Situ Expression of Proinsulin-Insulin in Pancreatic Islets Reflects Metabolic and Molecular Defects in Type 2 Diabetic and Glucose-Intolerant Living Donors (2021) (0)
Assessment of insulin-glucose uptake dose-response characteristics in the non-steady state (1998) (0)
1795-P: Proinsulin-Insulin Pancreatic Islets In-situ Expression Mirrors Metabolic Defects Observed in Type 2 Diabetic and Glucose Intolerant Living Donors (2020) (0)
Atypical Progeroid Syndrome with Familial Partial Lipodystrophy due to A Missense c.1045 C > T LMNA Mutation: A Case Report and an Innovative Therapeutic Approach (2022) (0)
Erratum. Effects of Sustained Treatment With Lixisenatide on Gastric Emptying and Postprandial Glucose Metabolism in Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Care 2020;43:1813-1821. (2020) (0)
1122-P: Physiological Effects of Pioglitazone in Ataxia-Telangiectasia (2019) (0)
Insulin resistance impairs human liver progenitor cell function in vitro: Consequences for liver injury and tumorigenesis in metabolic disease and type 2 diabetes? (2015) (0)
b-Cell Glucose Sensitivity determines hyperglycaemia in Polycystic Ovary Syndrome (2020) (0)
Effects of the long-acting human GLP-1 analogue liraglutide on β-cell function in normal living conditions Received for publication 14 February 2007 and accepted in revised form 21 April 2007. (2007) (0)
173-OR: Effects of Mild Acute Hypertriglyceridemia on Fasting and Post-Load Glucose Homeostasis (2019) (0)
Mechanisms of post-prandial hypoglycaemia after Roux-en-Y gastricbypass (RYGB) and sleeve gastrectomy (LSG) (2014) (0)
What can a meal test tell us about the heritability of the beta cell function (2010) (0)
Acute Insulin Secretory Effects of a Classic Ketogenic Meal in Healthy Subjects: A Randomized Cross-Over Study (2018) (0)
The association between sleep duration and insulin sensitivity: the EGIR-RISC study (2015) (0)
722-P: Tirzepatide Improves Multiple Aspects of Beta-Cell Function (2022) (0)
Prediction of liver fat in people with and without type 2 diabetes: an IMI DIRECT study: a randomised crossover study (2018) (0)
GLP-1 RECEPTOR VARIANTS MARKEDLY DIFFERENTIATE GLYCAEMIC RESPONSE TO GLP-1 RECEPTOR AGONISTS : A DIRECT STUDY (2017) (0)
Insulin Resistance Impairs Cognitive Performance Even in Healthy Subjects at Risk for Diabetes Mellitus (2018) (0)
1186-P: Mechanisms of Glucose Intolerance Induced by Excess Triglycerides and Free Fatty Acids (2021) (0)
Characterization of Drug Distribution with a Circulatory Model: Analysis of Lacidipine Pharmacokinetics (2000) (0)
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes (2020) (0)
Distribution of OGTT-Related Variables in Patients with Cystic Fibrosis from Puberty to Adulthood: An Italian Multicenter Study (2023) (0)
189-OR: Plasma Proteome Profiling of Prediabetes and Diabetes Progression: An IMI Direct Study (2019) (0)
134-OR: Effects of PCSK9 Inhibitors on Glucose Metabolism and ß-Cell Function in Humans (2020) (0)
A genome-wide association study of IVGTT-based measures of first phase insulin secretion refines the underlying physiology of type 2 diabetes variants Mechanisms of type 2 diabetes genetic risk factors (2017) (0)
1851-P: Renal Denervation Attenuates Endogenous Glucose Production Increase with SGLT2 Inhibition in Patients with Renal Transplant Recipients and Impaired Fasting Glucose (2020) (0)
Identification of the Single-Pass Impulse Response of the Body Tissues with Circulatory Models (1994) (0)
Correction to: One hour post-load plasma glucose and 3 year risk of worsening fasting and 2 hour glucose tolerance in the RISC cohort (2019) (0)
PS6 - 30. Fasting and postprandial GLP-1 and GIP in relation to alanine aminotransterase and lipid metabolism in the general population (2011) (0)
Determinants of glucagon-like peptide-1 (GLP-1) response in prediabetes and diabetes : an IMI-DIRECT study (2016) (0)
exercise in patients with type 2 diabetes risk factors more effectively than predinner resistance Postdinner resistance exercise improves postprandial (2015) (0)
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study (2020) (0)
Common variants in the GLP-1 receptor are associated with glycaemic response to GLP-1 receptor agonists in observational and large RCT data: an IMI-DIRECT study (2018) (0)
Abstract P442: Habitual Dietary Fat Intake and Meal-derived Measures of Insulin Sensitivity and Secretion: A Population-based Cross-sectional Study (2013) (0)
PTCA acutely expands perfused myocardial mass and increases flow homogeneity (2003) (0)
1826-P: Comparison of OGTT-Model Measures with the Hyperglycemic Clamp in Youth and Adults with IGT or Early Type 2 Diabetes (DM) (2019) (0)
1261-P: OGTT Model–Derived ß-Cell Function Reveals Differential Loss in Youth vs. Adults during and following Treatment Withdrawal in the Restoring Insulin Secretion (RISE) Study (2020) (0)
Progression of Beta Cell Dysfunction in Subjects at Risk for Type 1 Diabetes (2010) (0)
Evaluation of renal glucose uptake with [18F]FDG-PET: Methodological advancements and metabolic outcomes. (2022) (0)
Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study (2020) (0)
severe stenosis : pressure-flow Clinical evidence for myocardial derecruitment (2000) (0)
University of Dundee Processes Underlying Glycemic Deterioration in Type 2 Diabetes IMI DIRECT Consortium; Bizzotto, Roberto; Jennison, Christopher; Jones, Angus G.; Kurbasic, (2020) (0)
Imatinib Therapy for Patients with Recent-Onset Type 1 Diabetes: A Randomised Blinded Phase 2 Trial (2021) (0)
Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study (2020) (0)
In Insulin-Resistant Subjects, Islet Functional Changes Might Represent an Attempt to Increase the Incretin Effect (2018) (0)
alogliptin and pioglitazone combination therapy improves beta-cell function in patients with recent-onset type 2 diabetes ChaPTeR 6 (2013) (0)
β-Cell Glucose Sensitivity determines hyperglycaemia in Polycystic Ovary Syndrome (2020) (0)
Physiological predictors of changes in glucose tolerance in a non-diabetic population: the RISC Study (2010) (0)
Mechanisms of progression to type 1 diabetes Progression to diabetes in relatives of type 1 diabetic patients : mechanisms and mode of onset . Running title : Mechanisms of progression to type 1 diabetes (2009) (0)
Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo—The Maastricht Study (2023) (0)
metabolism: a non-steady-state approach Dose-response characteristics of insulin action on glucose (2013) (0)
Insulin-induced stimulation of insulin secretion, its relation to insulin sensitivity and impact on impaired glucose regulation (2011) (0)
University of Dundee Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes Koivula, (2014) (0)
The incretin effect is apparent after lipid challenge in healthy humans (2010) (0)
1780-P: Differential Effects of Medications and Gastric Banding on OGTT-Modeled Measures of ß-Cell Function in Adults with IGT or Recent-Onset Type 2 Diabetes (T2D) (2020) (0)
The heritability of meal related-cell function Chapter 4 The heritability of-cell function parameters in a mixed meal test design (2010) (0)
2295-PUB: Impaired First-Phase Insulin Secretion Predicts the Development of Hyperglycemia in a Human Model of Acute Beta-Cell Mass Reduction (2020) (0)
Does glucose lowering restore GIP effects on insulin secretion? (2023) (0)
EFFECT OF EARLY DERANGEMENTS IN GLUCOSE TOLERANCE MECHANISMS ON THE NUTRITIONAL STATUS AND RESPIRATORY FUNCTION OF CYSTIC FIBROSIS PATIENTS (2010) (0)
Comparative evaluation of simple OGTT insulin sensitivity methods (2004) (0)
A Model for Assessing Insulin Secretion Function During a 24 Hour Standardized Life Period (2000) (0)
Mechanism of Action and Metabolic Effects of Exenatide in Obesity (2013) (0)
A Circulatory Model for Assessing Non-Steady-State Glucose Kinetics During a Euglycemic Clamp (1994) (0)
Calculation of Uptake and Production with Impulse Response Methods (1994) (0)
Author Correction: Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models. (2023) (0)

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