Andrea Mari
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Italian bioengineer
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Bioengineering
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Biomedical Engineering
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Why Is Andrea Mari Influential?
(Suggest an Edit or Addition)Andrea Mari's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. (2014) (825)
- A Model-Based Method for Assessing Insulin Sensitivity From the Oral Glucose Tolerance Test (2001) (606)
- How to measure insulin sensitivity (1998) (528)
- beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. (2005) (491)
- Shift to Fatty Substrate Utilization in Response to Sodium–Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes (2016) (439)
- Separate Impact of Obesity and Glucose Tolerance on the Incretin Effect in Normal Subjects and Type 2 Diabetic Patients (2008) (388)
- Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes. (2005) (375)
- Mechanisms of Recovery From Type 2 Diabetes After Malabsorptive Bariatric Surgery (2006) (355)
- Meal and oral glucose tests for assessment of beta -cell function: modeling analysis in normal subjects. (2002) (296)
- Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance (2013) (295)
- Common Variants of the Novel Type 2 Diabetes Genes CDKAL1 and HHEX/IDE Are Associated With Decreased Pancreatic β-Cell Function (2007) (255)
- Visceral Fat in Hypertension: Influence on Insulin Resistance and β-Cell Function (2004) (250)
- The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients. (2007) (244)
- Roux-en-Y gastric bypass and sleeve gastrectomy: mechanisms of diabetes remission and role of gut hormones. (2013) (243)
- Assessing insulin secretion by modeling in multiple-meal tests: role of potentiation. (2002) (239)
- Beta cell function and its relation to insulin action in humans: a critical appraisal (2004) (236)
- Methods for clinical assessment of insulin sensitivity and β-cell function (2003) (231)
- Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes (2011) (197)
- The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and Objectives (2004) (180)
- Free fatty acids impair hepatic insulin extraction in vivo. (1999) (180)
- Insulin resistance, insulin response, and obesity as indicators of metabolic risk. (2007) (176)
- A Model-Based Method for Assessing Insulin Sensitivity From the Oral Glucose Tolerance Test. Diabetes Care 2001;24:539–548 (2014) (169)
- Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients. (1999) (169)
- Methods for clinical assessment of insulin sensitivity and beta-cell function. (2003) (167)
- The role of beta-cell function and insulin sensitivity in the remission of type 2 diabetes after gastric bypass surgery. (2011) (165)
- Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans. (2011) (163)
- A Central Role for GRB10 in Regulation of Islet Function in Man (2014) (159)
- Acute and 2-week exposure to prednisolone impair different aspects of beta-cell function in healthy men. (2010) (154)
- Non-steady state: error analysis of Steele's model and developments for glucose kinetics. (1987) (152)
- beta-cell function in obesity: effects of weight loss. (2004) (136)
- Dapagliflozin lowers plasma glucose concentration and improves β-cell function. (2015) (135)
- Thiazolidinediones improve beta-cell function in type 2 diabetic patients. (2007) (132)
- Efficacy and tolerability of vildagliptin in drug‐naïve patients with type 2 diabetes and mild hyperglycaemia * (2008) (126)
- Evidence that vildagliptin attenuates deterioration of glycaemic control during 2‐year treatment of patients with type 2 diabetes and mild hyperglycaemia * (2008) (122)
- Metabolic Effects of Chronic Cannabis Smoking (2013) (122)
- Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance. (2009) (117)
- Liver Enzymes Are Associated With Hepatic Insulin Resistance, Insulin Secretion, and Glucagon Concentration in Healthy Men and Women (2011) (117)
- Restoration of normal glucose tolerance in severely obese patients after bilio-pancreatic diversion: role of insulin sensitivity and beta cell function (2006) (117)
- Progression to Diabetes in Relatives of Type 1 Diabetic Patients: Mechanisms and Mode of Onset (2009) (116)
- Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance (2003) (115)
- Dose-response characteristics of insulin action on glucose metabolism: a non-steady-state approach. (2000) (109)
- Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance (2010) (106)
- β-Cell function in type 2 diabetes. (2014) (105)
- beta-cell function in morbidly obese subjects during free living: long-term effects of weight loss. (2005) (102)
- Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes (2014) (101)
- Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes. (2012) (99)
- Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance (2012) (98)
- Within-subject variability of measures of beta cell function derived from a 2 h OGTT: implications for research studies (2007) (98)
- Estimation of the rate of appearance in the non-steady state with a two-compartment model. (1992) (98)
- Preeclampsia in Lean Normotensive Normotolerant Pregnant Women Can Be Predicted by Simple Insulin Sensitivity Indexes (2006) (97)
- Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test (2005) (97)
- Characterization of the influence of vildagliptin on model-assessed -cell function in patients with type 2 diabetes and mild hyperglycemia. (2008) (97)
- β‐cell function assessment from modelling of oral tests: an effective approach (2008) (94)
- Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training (2007) (94)
- Long-Term Effects of Bariatric Surgery on Meal Disposal and β-Cell Function in Diabetic and Nondiabetic Patients (2013) (90)
- Validation of mathematical models of complex endocrine-metabolic systems. A case study on a model of glucose regulation (1983) (90)
- Effect of acute hyperglycemia on insulin secretion in humans. (2002) (90)
- Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions. (2007) (89)
- Sclerostin and Insulin Resistance in Prediabetes: Evidence of a Cross Talk Between Bone and Glucose Metabolism (2015) (88)
- Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance. (2006) (86)
- A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants (2017) (85)
- Thiazolidinediones improve -cell function in type 2 diabetic patients (2007) (85)
- Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients. (2014) (84)
- Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response (2009) (83)
- Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. (2011) (82)
- Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial (2018) (79)
- Characterization of GLP-1 effects on beta-cell function after meal ingestion in humans. (2003) (77)
- Improved tolerance to sequential glucose loading (Staub-Traugott effect): size and mechanisms. (2009) (75)
- GLP-1 and Glucose Tolerance After Sleeve Gastrectomy in Morbidly Obese Subjects With Type 2 Diabetes (2014) (75)
- Assessment of insulin secretion in relation to insulin resistance (2005) (74)
- The effects of bariatric surgery on pancreatic lipid metabolism and blood flow. (2015) (74)
- Moderate alcohol consumption is associated with improved insulin sensitivity, reduced basal insulin secretion rate and lower fasting glucagon concentration in healthy women (2012) (73)
- Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study (2011) (73)
- Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men. (2009) (71)
- Identification, pathophysiology, and clinical implications of primary insulin hypersecretion in nondiabetic adults and adolescents. (2018) (71)
- Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea. (2006) (69)
- β-Cell Function, Incretin Effect, and Incretin Hormones in Obese Youth Along the Span of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes (2014) (68)
- Mathematical modeling in glucose metabolism and insulin secretion (2002) (68)
- Effects of meal size and composition on incretin, alpha-cell, and beta-cell responses. (2010) (66)
- Postdinner resistance exercise improves postprandial risk factors more effectively than predinner resistance exercise in patients with type 2 diabetes. (2015) (63)
- Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort. (2009) (62)
- A model for glucose control of insulin secretion during 24 h of free living. (2001) (61)
- Biliopancreatic diversion in nonobese patients with type 2 diabetes: impact and mechanisms. (2013) (60)
- Glucokinase links Krüppel‐like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease (2012) (60)
- Early detection of insulin sensitivity and beta-cell function with simple tests indicates future derangements in late pregnancy. (2008) (59)
- Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes (2008) (58)
- Imeglimin increases glucose‐dependent insulin secretion and improves β‐cell function in patients with type 2 diabetes (2015) (58)
- Effect of Pioglitazone on the Metabolic and Hormonal Response to a Mixed Meal in Type II Diabetes (2007) (56)
- Improvement in Insulin Sensitivity and Β-Cell Function Following Ileal Interposition with Sleeve Gastrectomy in Type 2 Diabetic Patients: Potential Mechanisms (2011) (55)
- Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp. (2013) (53)
- Glucose absorption and production following oral glucose: comparison of compartmental and arteriovenous-difference methods. (1994) (52)
- Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT. (2013) (51)
- Visceral fat and beta cell function in non-diabetic humans (2005) (51)
- Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles (2008) (50)
- Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium (2014) (49)
- Assessment of insulin sensitivity and secretion with the labelled intravenous glucose tolerance test: improved modelling analysis (1998) (49)
- A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models (2003) (48)
- Beta-cell function in severely obese type 2 diabetic patients: long-term effects of bariatric surgery. (2007) (47)
- Lipid-induced β-cell dysfunction in vivo in models of progressive β-cell failure (2007) (45)
- Identification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients. (2011) (44)
- Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency. (2012) (44)
- Mechanisms of hyperinsulinaemia in Child’s disease grade B liver cirrhosis investigated in free living conditions (2002) (44)
- Altered pattern of the incretin effect as assessed by modelling in individuals with glucose tolerance ranging from normal to diabetic (2014) (43)
- Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor (2008) (43)
- Mechanisms through which a small protein and lipid preload improves glucose tolerance (2015) (42)
- Progression to Type 2 Diabetes in Women with Former Gestational Diabetes: Time Trajectories of Metabolic Parameters (2012) (42)
- Influence of Hyperinsulinemia and Insulin Resistance on In Vivo β-Cell Function (2011) (42)
- Effects of portal free fatty acid elevation on insulin clearance and hepatic glucose flux. (2006) (40)
- Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts (2020) (40)
- Control of Diabetes with Artificial Systems for Insulin Delivery Algorithm Independent Limitations Revealed by a Modeling Study (1985) (39)
- Potentiation of the early-phase insulin response by a prior meal contributes to the second-meal phenomenon in type 2 diabetes. (2011) (38)
- Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic β-cell dysfunction. (2012) (37)
- m.3243A>G Mutation in Mitochondrial DNA Leads to Decreased Insulin Sensitivity in Skeletal Muscle and to Progressive β-Cell Dysfunction (2009) (37)
- Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects (2005) (37)
- Mechanisms of the Incretin Effect in Subjects with Normal Glucose Tolerance and Patients with Type 2 Diabetes (2013) (36)
- Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial. (2014) (36)
- Impaired glucose absorption in children with severe malnutrition. (2011) (35)
- Reconstructing the rate of appearance of subcutaneous insulin by deconvolution. (1987) (35)
- The effect of alogliptin and pioglitazone combination therapy on various aspects of β-cell function in patients with recent-onset type 2 diabetes. (2014) (34)
- Assessment of insulin sensitivity with minimal model: role of model assumptions. (1997) (34)
- Discriminatory ability of simple OGTT-based beta cell function indices for prediction of prediabetes and type 2 diabetes: the CODAM study (2016) (33)
- Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion (2013) (33)
- Coronary microcirculatory vasoconstriction is heterogeneously distributed in acutely ischemic myocardium. (2005) (33)
- Plasma HDL-cholesterol and triglycerides, but not LDL-cholesterol, are associated with insulin secretion in non-diabetic subjects. (2017) (33)
- Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure. (2007) (32)
- Effects of subcutaneous tirzepatide versus placebo or semaglutide on pancreatic islet function and insulin sensitivity in adults with type 2 diabetes: a multicentre, randomised, double-blind, parallel-arm, phase 1 clinical trial. (2022) (32)
- Circulatory models of intact-body kinetics and their relationship with compartmental and non-compartmental analysis. (1993) (31)
- Impaired β‐cell function in lean normotolerant former gestational diabetic women (2006) (31)
- Incretin and islet hormone responses to meals of increasing size in healthy subjects. (2015) (30)
- Glucose‐lowering effect of the DPP‐4 inhibitor sitagliptin after glucose and non‐glucose macronutrient ingestion in non‐diabetic subjects (2013) (30)
- β-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans. (2016) (30)
- Effect of Dapagliflozin With and Without Acipimox on Insulin Sensitivity and Insulin Secretion in T2DM Males. (2016) (29)
- Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance? (2013) (29)
- Improvement in β-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes. (2012) (29)
- Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men (2009) (28)
- Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. (2021) (28)
- A Circulatory Model for the Estimation of Insulin Sensitivity (1997) (28)
- The Association Between Sleep Duration, Insulin Sensitivity, and β-Cell Function: The EGIR-RISC Study. (2016) (27)
- Hepatic fat is not associated with beta-cell function or postprandial free fatty acid response. (2009) (26)
- Beta-cell function in mild type 2 diabetic patients: effects of 6-month glucose lowering with nateglinide. (2005) (26)
- Postprandial metabolic responses to mixed versus liquid meal tests in healthy men and men with type 2 diabetes. (2011) (26)
- Risk Factors for Spontaneously Self-Reported Postprandial Hypoglycemia After Bariatric Surgery. (2016) (26)
- Characterization of beta-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests. (2005) (26)
- Reduced insulin clearance and insulin degrading enzyme activity contribute to hyperinsulinemia in African Americans. (2020) (26)
- Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium (2019) (26)
- Increased β-Cell Workload Modulates Proinsulin-to-Insulin Ratio in Humans (2018) (25)
- Influence of endogenous NEFA on beta cell function in humans (2015) (25)
- Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance. (2010) (25)
- Circulating palmitoleic acid is an independent determinant of insulin sensitivity, beta cell function and glucose tolerance in non-diabetic individuals: a longitudinal analysis (2019) (24)
- Effects of Leptin Replacement Therapy on Pancreatic β-Cell Function in Patients With Lipodystrophy (2014) (23)
- Mixed meal ingestion diminishes glucose excursion in comparison with glucose ingestion via several adaptive mechanisms in people with and without type 2 diabetes (2016) (23)
- Exenatide improves β-cell function up to 3 years of treatment in patients with type 2 diabetes: a randomised controlled trial. (2016) (23)
- Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study (2022) (22)
- One‐hour post‐load plasma glucose predicts progression to prediabetes in a multi‐ethnic cohort of obese youths (2019) (22)
- Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion (2015) (22)
- Metabolic consequences of acute and chronic empagliflozin administration in treatment-naive and metformin pretreated patients with type 2 diabetes (2016) (21)
- Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes (T2DM) and mild hyperglycemia (2008) (21)
- Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects (2006) (21)
- Defective Amplifying Pathway of β-Cell Secretory Response to Glucose in Type 2 Diabetes: Integrated Modeling of In Vitro and In Vivo Evidence (2017) (20)
- The insulinotropic effect of a high-protein nutrient preload is mediated by the increase of plasma amino acids in type 2 diabetes (2018) (20)
- Impaired beta-cell function in lean normotolerant former gestational diabetic women. (2006) (20)
- Determination of the single-pass impulse response of the body tissues with circulatory models (1995) (20)
- Inhibition of sweet chemosensory receptors alters insulin responses during glucose ingestion in healthy adults: a randomized crossover interventional study. (2017) (20)
- Lifetime congenital isolated GH deficiency does not protect from the development of diabetes (2013) (20)
- The potential role of the osteopontin–osteocalcin–osteoprotegerin triad in the pathogenesis of prediabetes in humans (2017) (19)
- Intrahepatic fat, irrespective of ethnicity, is associated with reduced endogenous insulin clearance and hepatic insulin resistance in obese youths: a cross-sectional and longitudinal study from the Yale Pediatric NAFLD cohort. (2020) (19)
- Sustained effects of a protein and lipid preload on glucose tolerance in type 2 diabetes patients. (2016) (19)
- Effects of meal and incretins in the regulation of splanchnic blood flow (2017) (19)
- Metformin increases fasting glucose clearance and endogenous glucose production in non-diabetic individuals (2019) (19)
- Associations between sleep duration and sleep debt with insulin sensitivity and insulin secretion in the EGIR-RISC Study. (2019) (18)
- Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models. (2012) (18)
- Measurement of postprandial glucose fluxes in response to acute and chronic endurance exercise in healthy humans. (2018) (18)
- Value of the intravenous and oral glucose tolerance tests for detecting subtle impairments in insulin sensitivity and beta‐cell function in former gestational diabetes (2008) (18)
- Lack of association of liver fat with model parameters of beta-cell function in men with impaired glucose tolerance and type 2 diabetes. (2008) (17)
- Differences in β‐cell function and insulin secretion in Black vs. White obese adolescents: do incretin hormones play a role? (2017) (17)
- Glucose Metabolism in High-Risk Subjects for Type 2 Diabetes Carrying the rs7903146 TCF7L2 Gene Variant. (2015) (17)
- Influence of gestational diabetes on the long-term control of glucose tolerance (2007) (17)
- In fl uence of Hyperinsulinemia and Insulin Resistance on In Vivo b -Cell Function Their Role in Human b -Cell Dysfunction (2011) (17)
- Effects of Sustained Treatment With Lixisenatide on Gastric Emptying and Postprandial Glucose Metabolism in Type 2 Diabetes: A Randomized Controlled Trial (2020) (16)
- Roux‐en‐Y gastric bypass compared with equivalent diet restriction: Mechanistic insights into diabetes remission (2018) (16)
- On linearity of insulin kinetics. (1986) (16)
- Postprandial hypoglycaemia after Roux-en-Y gastric bypass in individuals with type 2 diabetes (2018) (16)
- Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response. (2017) (15)
- Mathematical Modeling for the Physiological and Clinical Investigation of Glucose Homeostasis and Diabetes (2020) (15)
- Associations of Dietary Glucose, Fructose, and Sucrose with β-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study (2017) (15)
- Age- and Sex-Dependent Distribution of OGTT-Related Variables in a Population of Cystic Fibrosis Patients. (2015) (14)
- Bariatric Surgery Enhances Splanchnic Vascular Responses in Patients With Type 2 Diabetes (2017) (14)
- Effect of exenatide on postprandial glucose fluxes, lipolysis, and ß‐cell function in non‐diabetic, morbidly obese patients (2017) (14)
- Clinical evidence for myocardial derecruitment downstream from severe stenosis: pressure-flow control interaction. (2000) (14)
- Effects of Low-Carbohydrate versus Mediterranean Diets on Weight Loss, Glucose Metabolism, Insulin Kinetics and β-Cell Function in Morbidly Obese Individuals (2021) (14)
- The Finnish Diabetes Risk Score is associated with insulin resistance but not reduced β‐cell function, by classical and model‐based estimates (2011) (14)
- The Effect of a Vegetarian vs Conventional Hypocaloric Diabetic Diet on Thigh Adipose Tissue Distribution in Subjects with Type 2 Diabetes: A Randomized Study (2017) (13)
- Differential effects of once‐weekly glucagon‐like peptide‐1 receptor agonist dulaglutide and metformin on pancreatic β‐cell and insulin sensitivity during a standardized test meal in patients with type 2 diabetes (2016) (13)
- Intestinal Glucose Absorption Is a Key Determinant of 1-Hour Postload Plasma Glucose Levels in Nondiabetic Subjects. (2018) (13)
- Body Weight, Not Insulin Sensitivity or Secretion, May Predict Spontaneous Weight Changes in Nondiabetic and Prediabetic Subjects (2011) (12)
- Effects of acute NEFA manipulation on incretin-induced insulin secretion in participants with and without type 2 diabetes (2018) (12)
- Beta-cell function is associated with carotid intima-media thickness independently of insulin resistance in healthy individuals (2016) (12)
- Effect of ovarian suppression with gonadotropin-releasing hormone agonist on glucose disposal and insulin secretion. (2008) (12)
- Lumacaftor/ivacaftor in cystic fibrosis: effects on glucose metabolism and insulin secretion (2021) (12)
- 35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
- Improved Beta Cell Glucose Sensitivity Plays Predominant Role in the Decrease in HbA1c with Cana and Lira in T2DM. (2020) (11)
- Prospective associations of dietary carbohydrate, fat, and protein intake with β-cell function in the CODAM study (2018) (11)
- Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study (2020) (11)
- The heritability of beta cell function parameters in a mixed meal test design (2011) (11)
- Effect of single‐dose DPP‐4 inhibitor sitagliptin on β‐cell function and incretin hormone secretion after meal ingestion in healthy volunteers and drug‐naïve, well‐controlled type 2 diabetes subjects (2018) (11)
- Triglyceride‐rich very low‐density lipoproteins (VLDL) are independently associated with insulin secretion in a multiethnic cohort of adolescents (2018) (10)
- β‐cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults (2020) (10)
- Assessment of the Role of Metabolic Determinants on the Relationship between Insulin Sensitivity and Secretion (2016) (10)
- Methods for the Assessment of β‐Cell Function In Vivo (2007) (10)
- Reducing Cholesterol and Fat Intake Improves Glucose Tolerance by Enhancing &bgr; Cell Function in Nondiabetic Subjects (2018) (10)
- On the calculation of glucose rate of disappearance in nonsteady state. (1994) (10)
- Assessment of insulin action on glucose uptake and production during a euglycemic-hyperinsulinemic clamp in dog: a new kinetic analysis. (1997) (10)
- Liver blood dynamics after bariatric surgery: the effects of mixed-meal test and incretin infusions (2018) (10)
- Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study. (2013) (9)
- Calculation of organ and whole-body uptake and production with the impulse response approach (1995) (9)
- Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study (2021) (9)
- The amino acid response to a mixed meal in patients with type 2 diabetes: effect of sitagliptin treatment (2014) (9)
- A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals (2022) (9)
- Increase in endogenous glucose production with SGLT2 inhibition is attenuated in individuals who underwent kidney transplantation and bilateral native nephrectomy (2020) (9)
- Adaptation of β-Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance (2015) (9)
- Elevated Glucose Oxidation, Reduced Insulin Secretion, and a Fatty Heart May Be Protective Adaptions in Ischemic CAD (2016) (9)
- New Insights on the Interactions Between Insulin Clearance and the Main Glucose Homeostasis Mechanisms (2021) (8)
- Disruption of fasting and post-load glucose homeostasis are largely independent and sustained by distinct and early major beta-cell function defects: a cross-sectional and longitudinal analysis of the relationship between insulin sensitivity and cardiovascular risk (RISC) study cohort. (2020) (8)
- The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study (2020) (8)
- Glucose uptake saturation explains glucose kinetics profiles measured by different tests. (2016) (8)
- Persistent whole day meal effects of three dipeptidyl peptidase‐4 inhibitors on glycaemia and hormonal responses in metformin‐treated type 2 diabetes (2019) (8)
- Ventilation inhomogeneity is associated with OGTT‐derived insulin secretory defects in cystic fibrosis (2019) (8)
- Pharmacogenomics of GLP-1 Receptor Agonists: A genome-wide analysis of observational data and large randomized controlled trials (2022) (8)
- Association of artificially sweetened and sugar-sweetened soft drinks with β-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study (2019) (8)
- Fimasartan increases glucose‐stimulated insulin secretion in patients with type 2 diabetes and hypertension compared with amlodipine (2018) (8)
- Relationship between whole-body macronutrient oxidative partitioning and pancreatic insulin secretion/β-cell function in non-diabetic humans. (2014) (7)
- OPTIMIZED HUMAN REGULAR U-500 INSULIN TREATMENT IMPROVES β-CELL FUNCTION IN SEVERELY INSULIN-RESISTANT PATIENTS WITH LONG-STANDING TYPE 2 DIABETES AND HIGH INSULIN REQUIREMENTS. (2015) (7)
- Insulin resistance is central to long-term reversal of histologic non-alcoholic steatohepatitis after metabolic surgery. (2020) (7)
- The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans (2021) (7)
- GLP-1 response to sequential mixed meals: influence of insulin resistance. (2017) (7)
- Brain substrate metabolism and ß‐cell function in humans: A positron emission tomography study (2020) (7)
- The effect of a vegetarian versus conventional hypocaloric diet on serum concentrations of persistent organic pollutants in patients with type 2 diabetes. (2016) (7)
- β-Cell Function in Severely Obese Type 2 Diabetic Patients (2007) (7)
- Assessment of Insulin Sensitivity from Steady‐State and Dynamic Tests (2007) (7)
- Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study (2020) (6)
- One hour post-load plasma glucose and 3 year risk of worsening fasting and 2 hour glucose tolerance in the RISC cohort (2018) (6)
- Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes. (2020) (6)
- A model for assessing insulin secretion and its control under free-living conditions. (2001) (5)
- Noradrenergic fibers are associated with beta-cell dedifferentiation and impaired beta-cell function in humans. (2020) (5)
- Normal β‐cell function (2015) (5)
- Relationship between glucose volume of distribution and the extracellular space: a multiple tracer study. (2011) (5)
- Elevated heart rate predicts β cell function in non-diabetic individuals: the RISC cohort. (2015) (5)
- Contribution of defects in insulin sensitivity and beta-cell function to the changes over time in the glucose tolerance of cystic fibrosis patients (2006) (4)
- Physical Activity Associates with Muscle Insulin Sensitivity Postbariatric Surgery (2018) (4)
- Impact of a mild decrease in fasting plasma glucose on β-cell function in healthy subjects and patients with type 2 diabetes. (2016) (4)
- Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study (2020) (4)
- Interrelations between electrical and biochemical processes in ischemic porcine livers at low temperature. (1993) (4)
- Bile Modulates Secretion of Incretins and Insulin: A Study of Human Extrahepatic Cholestasis. (2019) (4)
- Nonalcoholic Fatty Liver Is Not Associated with the Relationship between Insulin Secretion and Insulin Sensitivity in Obese Children: Matched Case-Control Study. (2016) (4)
- Pancreaticoduodenectomy model demonstrates a fundamental role of dysfunctional β cells in predicting diabetes (2021) (4)
- Separate impact of obesity and glucose tolerance on incretin effect in humans (2007) (3)
- Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity (2020) (3)
- Syddansk Universitet Association analysis of 29 , 956 individuals confirms that a low-frequency variant at CCND 2 halves the risk of type 2 diabetes by enhancing insulin secretion (2015) (3)
- Insulin secretion and impaired glucose tolerance. Reply to Jenkins AB, Campbell LV [letter] (2010) (3)
- Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium (2018) (3)
- Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study. (2021) (3)
- A low n‐6 to n‐3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youth (2022) (3)
- Methods of Assessment of Insulin Sensitivity and β-Cell Function (2006) (3)
- Acute Administration of the GLP-1 Receptor Agonist Lixisenatide Diminishes Postprandial Insulin Secretion in Healthy Subjects But Not in Type 2 Diabetes, Associated with Slowing of Gastric Emptying (2022) (3)
- The Role of (cid:1) -Cell Function and Insulin Sensitivity in the Remission of Type 2 Diabetes after Gastric Bypass Surgery (2011) (3)
- Short Course of Insulin Treatment versus Metformin in Newly Diagnosed Patients with Type 2 Diabetes (2018) (3)
- The Impact of Low-dose Gliclazide on the Incretin Effect and Indices of Beta-cell Function (2021) (3)
- Beneficial Effects of RYGB on ß-Cell Function and Hepatic and Peripheral Insulin Sensitivity Are Maintained Seven Years after Surgery in Both Diabetic and Nondiabetic Subjects (2018) (2)
- Clinical profiles of post‐load glucose subgroups and their association with glycaemic traits over time: An IMI‐DIRECT study (2020) (2)
- Lipid-induced glucose intolerance is driven by impaired glucose kinetics and insulin metabolism in healthy individuals. (2022) (2)
- Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models (2023) (2)
- Intra-islet insulin synthesis defects are associated with endoplasmic reticulum stress and loss of beta cell identity in human diabetes (2022) (2)
- On the estimation of absorption of subcutaneous injected insulin from plasma concentrations using mathematical models (1984) (2)
- Phase 2 trial with imeglimin in patients with Type 2 diabetes indicates effects on insulin secretion and sensitivity (2022) (2)
- GLUTRAN : a Matlab toolbox for glucose tracer analysis (2009) (2)
- Exercise mode influences post‐exercise glucose sensitivity and insulin clearance in young, healthy males and females in a sex‐dependent manner: A randomized control trial (2022) (2)
- Comment on ‘Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial’. Reply to Amini P and Moharamzadeh S [letter] (2018) (2)
- Duodenopancreatectomy as a model to demonstrate the fundamental role of dysfunctional β cell in predicting diabetes. (2021) (2)
- Sleeping oxygen saturation, rapid eye movement sleep, and the adaptation of postprandial metabolic function in insulin sensitive and resistant individuals without diabetes (2018) (1)
- Fixed‐ratio combination of insulin glargine plus lixisenatide (iGlarLixi) improves ß‐cell function in people with type 2 diabetes (2022) (1)
- Clustering on baseline clinical variables identifies subgroups of type 2 diabetes patients with different rate of progression over 18 months: a DIRECT study (2017) (1)
- A reference map of potential determinants for the human serum metabolome (2020) (1)
- One-year exenatide treatment improves beta cell response in metformin treated patients with type 2 diabetes which is sustained after 5 weeks discontinuation of treatment (2009) (1)
- Association of serum lipids with β-cell function in obese children and adolescents (2019) (1)
- Influence of tissue acidification and halothane anesthesia on hepatic electrical and biochemical properties during ischemia. (1991) (1)
- The effect of age on longitudinal measures of beta cell function and insulin sensitivity during the progression of early stage type 1 diabetes (2022) (1)
- The Impact and Correction of Analysis Delay and Variability in Storage Temperature on the Assessment of HbA1c from Dried Blood Spots-an IMI DIRECT Study (2019) (1)
- Relationships between Glucose Clearance during an OGTT and a Euglycemic Clamp (2010) (1)
- Loss of the incretin effect in type 2 diabetes: a systematic review and meta-analysis. (2022) (1)
- Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes (2022) (1)
- Model Analysis of β-Cell Function in First-Degree Relatives of Type 2 Diabetics and Its Relation to Insulin Resistance (2002) (1)
- 261-OR: Dorzagliatin, a Dual-Acting Glucokinase Activator. Improves Insulin Secretion and Glucose Sensitivity in Glucokinase-Maturity-Onset Diabetes of the Young (GCK-MODY) (2022) (1)
- Postprandial GLP-1 Response Is Inversely Associated with Liver Fat (2009) (1)
- 714-P: Greater Improvement in Insulin Sensitivity Per Unit Weight Loss with Tirzepatide Compared with Selective GLP-1 Receptor Agonism (2022) (1)
- Heptanol effects on protected livers. (1990) (1)
- Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk (2020) (1)
- 124-OR: Comparison of OGTT Model-Derived Measures of ß-Cell Function between Youth and Adults (2019) (1)
- Abstract: P409 INCRETINS ARE ASSOCIATED WITH POSTPRANDIAL TRIGYCERIDES (2009) (1)
- Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study (2020) (1)
- Track 7 Diabetes and hyperlipidemia in obesity P205–P259 (2001) (0)
- Pathophysiology: Loss of β-Cell Function (2012) (0)
- 290-OR: Altered In-Situ Expression of Proinsulin-Insulin in Pancreatic Islets Reflects Metabolic and Molecular Defects in Type 2 Diabetic and Glucose-Intolerant Living Donors (2021) (0)
- Assessment of insulin-glucose uptake dose-response characteristics in the non-steady state (1998) (0)
- 1795-P: Proinsulin-Insulin Pancreatic Islets In-situ Expression Mirrors Metabolic Defects Observed in Type 2 Diabetic and Glucose Intolerant Living Donors (2020) (0)
- Atypical Progeroid Syndrome with Familial Partial Lipodystrophy due to A Missense c.1045 C > T LMNA Mutation: A Case Report and an Innovative Therapeutic Approach (2022) (0)
- Erratum. Effects of Sustained Treatment With Lixisenatide on Gastric Emptying and Postprandial Glucose Metabolism in Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Care 2020;43:1813-1821. (2020) (0)
- 1122-P: Physiological Effects of Pioglitazone in Ataxia-Telangiectasia (2019) (0)
- Insulin resistance impairs human liver progenitor cell function in vitro: Consequences for liver injury and tumorigenesis in metabolic disease and type 2 diabetes? (2015) (0)
- b-Cell Glucose Sensitivity determines hyperglycaemia in Polycystic Ovary Syndrome (2020) (0)
- Effects of the long-acting human GLP-1 analogue liraglutide on β-cell function in normal living conditions Received for publication 14 February 2007 and accepted in revised form 21 April 2007. (2007) (0)
- 173-OR: Effects of Mild Acute Hypertriglyceridemia on Fasting and Post-Load Glucose Homeostasis (2019) (0)
- Mechanisms of post-prandial hypoglycaemia after Roux-en-Y gastricbypass (RYGB) and sleeve gastrectomy (LSG) (2014) (0)
- What can a meal test tell us about the heritability of the beta cell function (2010) (0)
- Acute Insulin Secretory Effects of a Classic Ketogenic Meal in Healthy Subjects: A Randomized Cross-Over Study (2018) (0)
- The association between sleep duration and insulin sensitivity: the EGIR-RISC study (2015) (0)
- 722-P: Tirzepatide Improves Multiple Aspects of Beta-Cell Function (2022) (0)
- Prediction of liver fat in people with and without type 2 diabetes: an IMI DIRECT study: a randomised crossover study (2018) (0)
- GLP-1 RECEPTOR VARIANTS MARKEDLY DIFFERENTIATE GLYCAEMIC RESPONSE TO GLP-1 RECEPTOR AGONISTS : A DIRECT STUDY (2017) (0)
- Insulin Resistance Impairs Cognitive Performance Even in Healthy Subjects at Risk for Diabetes Mellitus (2018) (0)
- 1186-P: Mechanisms of Glucose Intolerance Induced by Excess Triglycerides and Free Fatty Acids (2021) (0)
- Characterization of Drug Distribution with a Circulatory Model: Analysis of Lacidipine Pharmacokinetics (2000) (0)
- The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes (2020) (0)
- Distribution of OGTT-Related Variables in Patients with Cystic Fibrosis from Puberty to Adulthood: An Italian Multicenter Study (2023) (0)
- 189-OR: Plasma Proteome Profiling of Prediabetes and Diabetes Progression: An IMI Direct Study (2019) (0)
- 134-OR: Effects of PCSK9 Inhibitors on Glucose Metabolism and ß-Cell Function in Humans (2020) (0)
- A genome-wide association study of IVGTT-based measures of first phase insulin secretion refines the underlying physiology of type 2 diabetes variants Mechanisms of type 2 diabetes genetic risk factors (2017) (0)
- 1851-P: Renal Denervation Attenuates Endogenous Glucose Production Increase with SGLT2 Inhibition in Patients with Renal Transplant Recipients and Impaired Fasting Glucose (2020) (0)
- Identification of the Single-Pass Impulse Response of the Body Tissues with Circulatory Models (1994) (0)
- Correction to: One hour post-load plasma glucose and 3 year risk of worsening fasting and 2 hour glucose tolerance in the RISC cohort (2019) (0)
- PS6 - 30. Fasting and postprandial GLP-1 and GIP in relation to alanine aminotransterase and lipid metabolism in the general population (2011) (0)
- Determinants of glucagon-like peptide-1 (GLP-1) response in prediabetes and diabetes : an IMI-DIRECT study (2016) (0)
- exercise in patients with type 2 diabetes risk factors more effectively than predinner resistance Postdinner resistance exercise improves postprandial (2015) (0)
- Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study (2020) (0)
- Common variants in the GLP-1 receptor are associated with glycaemic response to GLP-1 receptor agonists in observational and large RCT data: an IMI-DIRECT study (2018) (0)
- Abstract P442: Habitual Dietary Fat Intake and Meal-derived Measures of Insulin Sensitivity and Secretion: A Population-based Cross-sectional Study (2013) (0)
- PTCA acutely expands perfused myocardial mass and increases flow homogeneity (2003) (0)
- 1826-P: Comparison of OGTT-Model Measures with the Hyperglycemic Clamp in Youth and Adults with IGT or Early Type 2 Diabetes (DM) (2019) (0)
- 1261-P: OGTT Model–Derived ß-Cell Function Reveals Differential Loss in Youth vs. Adults during and following Treatment Withdrawal in the Restoring Insulin Secretion (RISE) Study (2020) (0)
- Progression of Beta Cell Dysfunction in Subjects at Risk for Type 1 Diabetes (2010) (0)
- Evaluation of renal glucose uptake with [18F]FDG-PET: Methodological advancements and metabolic outcomes. (2022) (0)
- Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study (2020) (0)
- severe stenosis : pressure-flow Clinical evidence for myocardial derecruitment (2000) (0)
- University of Dundee Processes Underlying Glycemic Deterioration in Type 2 Diabetes IMI DIRECT Consortium; Bizzotto, Roberto; Jennison, Christopher; Jones, Angus G.; Kurbasic, (2020) (0)
- Imatinib Therapy for Patients with Recent-Onset Type 1 Diabetes: A Randomised Blinded Phase 2 Trial (2021) (0)
- Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study (2020) (0)
- In Insulin-Resistant Subjects, Islet Functional Changes Might Represent an Attempt to Increase the Incretin Effect (2018) (0)
- alogliptin and pioglitazone combination therapy improves beta-cell function in patients with recent-onset type 2 diabetes ChaPTeR 6 (2013) (0)
- β-Cell Glucose Sensitivity determines hyperglycaemia in Polycystic Ovary Syndrome (2020) (0)
- Physiological predictors of changes in glucose tolerance in a non-diabetic population: the RISC Study (2010) (0)
- Mechanisms of progression to type 1 diabetes Progression to diabetes in relatives of type 1 diabetic patients : mechanisms and mode of onset . Running title : Mechanisms of progression to type 1 diabetes (2009) (0)
- Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo—The Maastricht Study (2023) (0)
- metabolism: a non-steady-state approach Dose-response characteristics of insulin action on glucose (2013) (0)
- Insulin-induced stimulation of insulin secretion, its relation to insulin sensitivity and impact on impaired glucose regulation (2011) (0)
- University of Dundee Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes Koivula, (2014) (0)
- The incretin effect is apparent after lipid challenge in healthy humans (2010) (0)
- 1780-P: Differential Effects of Medications and Gastric Banding on OGTT-Modeled Measures of ß-Cell Function in Adults with IGT or Recent-Onset Type 2 Diabetes (T2D) (2020) (0)
- The heritability of meal related-cell function Chapter 4 The heritability of-cell function parameters in a mixed meal test design (2010) (0)
- 2295-PUB: Impaired First-Phase Insulin Secretion Predicts the Development of Hyperglycemia in a Human Model of Acute Beta-Cell Mass Reduction (2020) (0)
- Does glucose lowering restore GIP effects on insulin secretion? (2023) (0)
- EFFECT OF EARLY DERANGEMENTS IN GLUCOSE TOLERANCE MECHANISMS ON THE NUTRITIONAL STATUS AND RESPIRATORY FUNCTION OF CYSTIC FIBROSIS PATIENTS (2010) (0)
- Comparative evaluation of simple OGTT insulin sensitivity methods (2004) (0)
- A Model for Assessing Insulin Secretion Function During a 24 Hour Standardized Life Period (2000) (0)
- Mechanism of Action and Metabolic Effects of Exenatide in Obesity (2013) (0)
- A Circulatory Model for Assessing Non-Steady-State Glucose Kinetics During a Euglycemic Clamp (1994) (0)
- Calculation of Uptake and Production with Impulse Response Methods (1994) (0)
- Author Correction: Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models. (2023) (0)
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