Andrew D. Hamilton

Why Is Andrew D. Hamilton Influential?

According to Wikipedia, Andrew David Hamilton is a British American chemist and academic administrator who served as the 16th president of New York University from 2016 to 2023. He previously served as vice chancellor of the University of Oxford from 2009 to 2015 and provost of Yale University from 2004 to 2008.

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Andrew D. Hamilton's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Water gelation by small organic molecules. (2004) (1557)
Label-free immunodetection with CMOS-compatible semiconducting nanowires (2007) (1275)
Targeting protein prenylation for cancer therapy (2011) (517)
Antiparallel Leucine Zipper-Directed Protein Reassembly: Application to the Green Fluorescent Protein (2000) (486)
Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt (2004) (446)
Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation* (2001) (443)
Molecular recognition: hydrogen-bonding receptors that function in highly competitive solvents (1993) (427)
Peptide and protein recognition by designed molecules. (2000) (405)
Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism. (2005) (405)
Strategies for targeting protein-protein interactions with synthetic agents. (2005) (399)
Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes (*) (1995) (379)
Macrocyclic anion receptors based on directed hydrogen bonding interactions (2003) (298)
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies (2000) (293)
Molecular recognition of biologically interesting substrates: synthesis of an artificial receptor for barbiturates employing six hydrogen bonds (1988) (283)
Recent advances in the development of aryl-based foldamers. (2009) (269)
The Phosphoinositide 3-OH Kinase/AKT2 Pathway as a Critical Target for Farnesyltransferase Inhibitor-Induced Apoptosis (2000) (260)
Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix. (2001) (256)
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines (1997) (244)
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. (2004) (242)
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts (1998) (237)
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. (1995) (233)
Formation of Artificial Receptors by Metal-Templated Self-Assembly. (1997) (230)
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. (1999) (224)
Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction. (2005) (217)
Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex. (2003) (211)
The Geranylgeranyltransferase-I Inhibitor GGTI-298 Arrests Human Tumor Cells in G0/G1 and Induces p21WAF1/CIP1/SDI1 in a p53-independent Manner* (1997) (206)
At the Interface of Organic and Inorganic Chemistry: Bioinspired Synthesis of Composite Materials (2001) (202)
Hydrogen Bonding and Molecular Recognition: Synthetic, Complexation, and Structural Studies on Barbiturate Binding to an Artificial Receptor (1991) (200)
Development of a Potent Bcl-xL Antagonist Based on α-Helix Mimicry (2002) (196)
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes. (1998) (194)
Oligoanthranilamides. Non-Peptide Subunits That Show Formation of Specific Secondary Structure (1996) (191)
Selective anion binding by a macrocycle with convergent hydrogen bonding functionality. (2001) (187)
In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. (2003) (186)
Effective Gelation of Water Using a Series of Bis‐urea Dicarboxylic Acids (2000) (184)
The Ras-related Protein Rheb Is Farnesylated and Antagonizes Ras Signaling and Transformation* (1997) (184)
Inhibition of Protein Geranylgeranylation and RhoA/RhoA Kinase Pathway Induces Apoptosis in Human Endothelial Cells* (2002) (184)
Induced fit in synthetic receptors: nucleotide base recognition by a molecular hinge (1987) (183)
Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor(*) (1995) (182)
Molecular recognition in the solid state: controlled assembly of hydrogen-bonded molecular sheets (1991) (182)
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. (1996) (178)
Synthetic non-peptide mimetics of alpha-helices. (2007) (177)
Pattern recognition of proteins based on an array of functionalized porphyrins. (2006) (177)
An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. (2007) (173)
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts. (1996) (171)
Novel Folding Patterns in a Family of Oligoanthranilamides: Non-Peptide Oligomers That Form Extended Helical Secondary Structures (1997) (168)
Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics. (2010) (166)
A Calixarene with Four Peptide Loops: An Antibody Mimic for Recognition of Protein Surfaces (1997) (165)
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. (2005) (164)
Terphenyl-Based Bak BH3 α-Helical Proteomimetics as Low-Molecular-Weight Antagonists of Bcl-xL (2005) (160)
Molecular recognition: a remarkably simple receptor for the selective complexation of dicarboxylic acids (1990) (159)
p21WAF1/CIP1 Is Upregulated by the Geranylgeranyltransferase I Inhibitor GGTI-298 through a Transforming Growth Factor β- and Sp1-Responsive Element: Involvement of the Small GTPase RhoA (1998) (155)
Aromatic-aromatic interactions in molecular recognition: a family of artificial receptors for thymine that shows both face-to-face and edge-to-face orientations (1988) (151)
Design of organic solids (1998) (150)
Protein Surface Recognition by Synthetic Receptors: A Route to Novel Submicromolar Inhibitors for α-Chymotrypsin (1999) (150)
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells. (1997) (149)
Targeting protein–protein interactions by rational design: mimicry of protein surfaces (2006) (148)
A Dual Channel Fluorescence Chemosensor for Anions Involving Intermolecular Excited State Proton Transfer. (2001) (146)
A Self‐Assembling, Hydrogen‐Bonded Helix (1993) (143)
Inhibition of Ras prenylation: a novel approach to cancer chemotherapy. (1997) (139)
The Farnesyltransferase Inhibitor, FTI-2153, Blocks Bipolar Spindle Formation and Chromosome Alignment and Causes Prometaphase Accumulation during Mitosis of Human Lung Cancer Cells* (2001) (138)
Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion. (2002) (131)
Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues (2000) (129)
Hydrogen-Bonding Self-Assembly of Multichromophore Structures (1990) (127)
Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice (2000) (123)
Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation Requires Protein Geranylgeranylation but not Farnesylation* (1996) (122)
Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction. (2005) (118)
Pattern-based detection of different proteins using an array of fluorescent protein surface receptors. (2004) (116)
Inhibition of Rho GTPases with Protein Prenyltransferase Inhibitors Prevents Leukocyte Recruitment to the Central Nervous System and Attenuates Clinical Signs of Disease in an Animal Model of Multiple Sclerosis1 (2002) (115)
The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner* (2010) (113)
Computer-aided design of non-nucleoside inhibitors of HIV-1 reverse transcriptase. (2006) (113)
Molecular Recognition and Catalysis. Acceleration of Phosphodiester Cleavage by a Simple Hydrogen-Bonding Receptor (1992) (109)
Functional Synthetic Receptors (2005) (108)
Novel Molecular Scaffolds: Formation of Helical Secondary Structure in a Family of Oligoanthranilamides (1994) (108)
A Non-peptide Mimetic of Ras-CAAX: Selective Inhibition of Farnesyltransferase and Ras Processing (*) (1995) (108)
Protein surface recognition and proteomimetics: mimics of protein surface structure and function. (2005) (108)
Rigid macrocyclic triamides as anion receptors: anion-dependent binding stoichiometries and 1H chemical shift changes. (2003) (106)
Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase. (1994) (104)
Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors (2004) (104)
Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis (2004) (103)
RhoA Prenylation Is Required for Promotion of Cell Growth and Transformation and Cytoskeleton Organization but Not for Induction of Serum Response Element Transcription* (2000) (103)
Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation. (2010) (101)
Thermodynamic aspects of dicarboxylate recognition by simple artificial receptors. (2001) (101)
An organic hydrogel as a matrix for the growth of calcite crystals. (2004) (96)
Coreceptor molecules. Synthesis of metalloreceptors containing porphyrin subunits and formation of mixed substrate supermolecules by binding of organic substrates and of metal ions (1986) (94)
Benzoylurea Oligomers: Synthetic Foldamers That Mimic Extended α Helices (2007) (92)
Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics. (1993) (91)
Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides. (2007) (91)
α-Helix mimetics: outwards and upwards. (2014) (91)
Hydrogen bonding control of self-assembly: Simple isophthalic acid derivatives form cyclic hexameric aggregates (1994) (89)
Integrin-dependent Leukocyte Adhesion Involves Geranylgeranylated Protein(s)* (1999) (88)
Molecular recognition: bis-acylguanidiniums provide a simple family of receptors for phosphodiesters (1992) (88)
Inhibition of Protein Geranylgeranylation Causes a Superinduction of Nitric-oxide Synthase-2 by Interleukin-1β in Vascular Smooth Muscle Cells* (1997) (87)
Digital analysis of protein properties by an ensemble of DNA quadruplexes. (2009) (87)
Hydrogen-Bonded Ribbons, Tapes and Sheets as Motifs for Crystal Engineering (1998) (87)
Self-Assembling, Chromogenic Receptors for the Recognition of Dicarboxylic Acids (1995) (87)
Water Gelation by Small Organic Molecules (2004) (86)
Nucleotide base recognition: a macrocyclic receptor for adenine employing hydrogen bonding and aromatic stacking interactions (1989) (85)
Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin (2017) (85)
Geranylgeranyltransferase I Inhibitors Target RalB To Inhibit Anchorage-Dependent Growth and Induce Apoptosis and RalA To Inhibit Anchorage-Independent Growth (2007) (84)
Hydrogen-Bonding Control of Molecular Self-Assembly: Formation of a 2 + 2 Complex in Solution and the Solid State (1993) (83)
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I. (1999) (81)
Farnesyltransferase Inhibitors Potentiate the Antitumor Effect of Radiation on a Human Tumor Xenograft Expressing Activated HRAS1 (2000) (81)
p53 α-Helix mimetics antagonize p53/MDM2 interaction and activate p53 (2005) (79)
A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. (2009) (78)
Design of a synthetic foldamer that modifies the growth of calcite crystals. (2004) (77)
FEP-guided selection of bicyclic heterocycles in lead optimization for non-nucleoside inhibitors of HIV-1 reverse transcriptase. (2006) (77)
Characterization of an Organic Hydrogel: A Cryo‐Transmission Electron Microscopy and X‐ray Diffraction Study (2003) (77)
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells. (1998) (77)
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. (2003) (76)
ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL) (2004) (76)
Low molecular weight organogelators for water. (2003) (76)
Alkyne-linked 2,2-disubstituted-indolin-3-one oligomers as extended beta-strand mimetics. (2009) (75)
CALORIMETRIC INVESTIGATION OF GUANIDINIUM-CARBOXYLATE INTERACTIONS (1999) (74)
Peracetylated sugar derivatives show high solubility in liquid and supercritical carbon dioxide. (2002) (73)
CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice. (2001) (73)
Synthetic mimetics of protein secondary structure domains (2010) (72)
The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells (2003) (71)
Inhibitors of protein farnesyltransferase as novel anticancer agents. (2002) (71)
Synthesis and self-assembling properties of polymerizable organogelators. (2002) (71)
Synthesis of a 2,3‘;6‘,3‘ ‘-Terpyridine Scaffold as an α-Helix Mimetic (2005) (70)
A Combinatorial Library Approach to Artificial Receptor Design (1995) (69)
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity. (2001) (69)
Stabilization of helical domains in short peptides using hydrophobic interactions. (1995) (69)
Farnesyltransferase inhibitors as anticancer agents: current status. (2003) (67)
Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts. (2001) (67)
A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents (2003) (66)
Oxygenated hydrocarbon ionic surfactants exhibit CO2 solubility. (2005) (66)
Design and evaluation of nonfluorous CO2-soluble oligomers and polymers. (2009) (66)
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter (2007) (66)
Protein recognition by an ensemble of fluorescent DNA G-quadruplexes. (2009) (65)
Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold. (2000) (65)
Farnesyltransferase as a target for anticancer drug design. (1997) (64)
TGF-beta1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2. (2000) (64)
Blocking Angiogenesis and Tumorigenesis with GFA-116, a Synthetic Molecule that Inhibits Binding of Vascular Endothelial Growth Factor to its Receptor (2004) (64)
Ion-mediated conformational switches (2014) (64)
Recognition and Stabilization of an α-Helical Peptide by a Synthetic Receptor (1997) (63)
Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy (2009) (63)
Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on Ras in human hepatic stellate cells (2000) (63)
Acceleration of a Phosphate Diester Transesterification Reaction by Bis(alkylguanidinium) Receptors Containing an Appended General Base (1995) (61)
Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein. (2004) (61)
Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice (2011) (60)
Molecular Recognition of Proteins: Sequence-Selective Binding of Aspartate Pairs in Helical Peptides (1995) (60)
Direct Tumor Lysis by NK Cells Uses a Ras-Independent Mitogen-Activated Protein Kinase Signal Pathway 1 (2000) (60)
Protein-protein interaction inhibitors: small molecules from screening techniques. (2007) (59)
Carboxylic Acid Complexation by a Synthetic Analogue of the “Carboxylate-Binding Pocket” of Vancomycin (1988) (56)
Molecular Recognition in the Solid State: Hydrogen-Bonding Control of Molecular Aggregation (1994) (56)
Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains. (2007) (56)
The Geranylgeranyltransferase I Inhibitor GGTI-298 Induces Hypophosphorylation of Retinoblastoma and Partner Switching of Cyclin-dependent Kinase Inhibitors (1999) (56)
alpha-Helix mimetics as inhibitors of protein-protein interactions. (2008) (55)
Design of growth factor antagonists with antiangiogenic and antitumor properties (2000) (54)
MOLECULAR RECOGNITION OF CARBOHYDRATES : STRONG BINDING OF ALKYL GLYCOSIDES BY PHOSPHONATE DERIVATIVES (1994) (54)
Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth. (1998) (54)
Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors. (1996) (53)
Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold. (2010) (53)
Hydrogen Bonding Control of Molecular Self-Assembly: Aggregation Behavior of Acylaminopyridine–Carboxylic Acid Derivatives in Solution and the Solid State (2000) (53)
Metal templated receptors for the effective complexation of dicarboxylates (1995) (52)
Modulation of protein–protein interactions by synthetic receptors: Design of molecules that disrupt serine protease–proteinaceous inhibitor interaction (2002) (52)
The high CO 2-solubility of per-acetylated a-, -, and ?-cyclodextrin (2003) (52)
Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (2000) (50)
Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells. (2005) (50)
Targeting Protein–Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small‐Molecule, Nonpeptidic SH2 Domain Binders (2008) (50)
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. (2004) (49)
Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic. (2009) (49)
Catalytic unfolding and proteolysis of cytochrome C induced by synthetic binding agents. (2004) (48)
Disruption of protein-protein interactions: design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase. (2001) (48)
Differential effects of invasion by and phagocytosis of Salmonella typhimurium on apoptosis in human macrophages: potential role of Rho–GTPases and Akt (2003) (47)
α-Helix Mimetics as Modulators of Aβ Self-Assembly. (2017) (47)
Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold. (2009) (47)
The Guanidinium Group in Molecular Recognition: Design and Synthetic Approaches (2001) (46)
Protein recognition and denaturation by self-assembling fragments on a DNA quadruplex scaffold. (2007) (46)
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. (2004) (46)
Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II--preclinical studies in a nude mouse model. (1999) (46)
Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments. (2005) (46)
Poly(vinyl acetate), poly((1-O-(vinyloxy) ethyl-2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside) and amorphous poly(lactic acid) are the most CO2-soluble oxygenated hydrocarbon-based polymers (2008) (45)
Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry. (2002) (45)
Directed denaturation: room temperature and stoichiometric unfolding of cytochrome C by a metalloporphyrin dimer. (2003) (45)
Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. (2006) (45)
Nitronate anion recognition and modulation of ambident reactivity by hydrogen-bonding receptors. (2000) (45)
Transition-state stabilization and molecular recognition: acceleration of phosphoryl-transfer reactions by an artificial receptor (1990) (45)
XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41. (2002) (44)
Inhibition of Ras prenylation: a signaling target for novel anti-cancer drug design. (1997) (44)
The design of organic gelators: Solution and solid state properties of a family of bis-ureas (1998) (43)
Molecular recognition: Design and synthesis of artificial receptors employing directed hydrogen bonding interactions (1990) (43)
Controlling curvature in a family of oligoamide alpha-helix mimetics. (2008) (43)
Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I. (2006) (43)
Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics. (2015) (42)
Amphiphilic α-helix mimetics based on a benzoylurea scaffold. (2012) (41)
Designing protein denaturants: Synthetic agents induce cytochrome c unfolding at low concentrations and stoichiometries (2002) (41)
RAPID AND HIGHLY SELECTIVE CLEAVAGE OF RIBONUCLEOSIDE 2',3'-CYCLIC MONOPHOSPHATES BY DINUCLEAR CUII COMPLEXES (1997) (41)
Structure and Function of Benzoylurea‐Derived α‐Helix Mimetics Targeting the Bcl‐xL/Bak Binding Interface (2009) (41)
Synthetic analogs of the ristocetin binding site: Neutral, multidentate receptors for carboxylate recognition (1993) (41)
Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics. (1998) (41)
De novo protein surface design: use of cation-pi interactions to enhance binding between an alpha-helical peptide and a cationic molecule in 50 % aqueous solution. (2002) (40)
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. (2010) (40)
The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. (1999) (40)
Hydrogen-bonding control of molecular aggregation: Self-complementary subunits lead to rod-shaped structures in the solid state (1995) (40)
Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding. (2003) (40)
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. (2005) (40)
Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. (2006) (39)
Inhibitors of prenyl transferases (1997) (39)
Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation. (2008) (38)
Conformational Selectivity in Molecular Recognition: The Influence of Artificial Receptors on the Cis-Trans Isomerization of Acylprolines (1991) (38)
Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NFκB ligand (RANKL) or tumor necrosis factor-α (TNF-α) (2005) (38)
Synthetic Inhibitors of Extended Helix–Protein Interactions Based on a Biphenyl 4,4′‐Dicarboxamide Scaffold (2009) (38)
Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. (2006) (38)
Foldamer-Mediated Structural Rearrangement Attenuates Aβ Oligomerization and Cytotoxicity. (2017) (37)
Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase (2007) (37)
Anion-dependent switching: dynamically controlling the conformation of hydrogen-bonded diphenylacetylenes. (2011) (37)
Protein surface recognition by synthetic agents: Design and structural requirements of a family of artificial receptors that bind to cytochrome C (1998) (37)
A tetraguanidinium ligand binds to the surface of the tetramerization domain of protein P53. (2004) (37)
Carbohydrate recognition: Enantioselective spirobifluorene diphosphonate receptors (1997) (37)
Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf (2003) (36)
Surface Recognition and Helix Stabilization of a Tetraaspartate Peptide by Shape and Electrostatic Complementarity of an Artificial Receptor (1999) (36)
Linked bis-isophthalic acid derivatives as bulding blocks in the design of self-assembling structures (1996) (35)
Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. (2009) (35)
Diphenylacetylene-linked peptide strands induce bidirectional β-sheet formation. (2014) (35)
Binuclear complexes of a covalently linked porphyrin-bipyridine ligand (1984) (35)
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites. (2006) (34)
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. (2009) (34)
Designed molecular switches: controlling the conformation of benzamido-diphenylacetylenes. (2010) (34)
The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status (2002) (34)
Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix. (2006) (34)
Artificial receptors for biologically active molecules (1988) (34)
Controlling Hydrogen Bonding: From Molecular Recognition to Organogelation (2000) (33)
Molecular recognition: directed hydrogen bonding receptors for acylamino acid carboxylates (1992) (33)
Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. (2006) (32)
Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). (2015) (32)
Synthetic hydrogen bonding receptors as models of transacylase enzymes (1995) (32)
Supramolecular control of structure and reactivity (1996) (32)
Combinatorial protein recognition as an alternative approach to antibody-mimetics. (2010) (32)
Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors (2019) (31)
Nucleotide base recognition: Ditopic binding of guanine to a macrocyclic receptor containing naphthyridine and naphthalene units (1988) (31)
Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL. (2005) (31)
Design and synthesis of multiple-loop receptors based on a calix〚4〛arene scaffold for protein surface recognition (2002) (31)
Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an α-helical conformation☆ (1997) (30)
Double-sided α-helix mimetics (2012) (30)
Peptidomimetic-Based Multidomain Targeting Offers Critical Evaluation of Aβ Structure and Toxic Function. (2018) (29)
Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization. (1998) (29)
Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors. (1995) (29)
Rapid and highly base selective RNA cleavage by a dinuclear Cu(II) complex (1999) (29)
CATALYSIS OF PHOSPHODIESTER TRANSESTERIFICATION BY CU(II)-TERPYRIDINE COMPLEXES WITH PERIPHERAL PENDENT BASE GROUPS : IMPLICATIONS FOR THE MECHANISM (1997) (29)
Allosteric control of self-assembly: modulating the formation of guanine quadruplexes through orthogonal aromatic interactions. (2007) (29)
Molecular recognition and the design of solid state structures: protonation-induced conformational change and self-assembly of 2,6-diamidopyridinium phosphates (1991) (29)
Peptidomimetic inhibitors of p21ras farnesyltransferase: Hydrophobic functionalization leads to disruption of p21ras membrane association in whole cells (1994) (28)
Inhibition of farnesyltransferase increases TGFβ type II receptor expression and enhances the responsiveness of human cancer cells to TGFβ (2000) (28)
Synthesis of a doubly-bridged oxygen-carrier which shows reduced affinity for carbon monoxide (1980) (28)
Farnesyltransferase Inhibitors in Cancer Therapy (2000) (28)
A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic. (2012) (28)
Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I. (2000) (27)
Self-assembling DNA quadruplex conjugated to MRI contrast agents. (2009) (27)
Designed Cell-Penetrating Peptide Inhibitors of Amyloid-beta Aggregation and Cytotoxicity (2020) (27)
Recognition of solvent exposed protein surfaces using anthracene derived receptors. (2007) (27)
Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function (2020) (27)
Farnesylated RhoB Prevents Cell Cycle Arrest and Actin Cytoskeleton Disruption Caused by the Geranylgeranyltransferase I Inhibitor GGTI-298 (2002) (26)
A self-assembling receptor for dicarboxylic acids (1994) (26)
Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I. (2007) (26)
p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53. (2005) (26)
Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents. (2009) (26)
β-Strand mimetic foldamers rigidified through dipolar repulsion. (2015) (26)
Catalysis of phosphodiester transesterification by dinuclear Cu(II) complexes: The role of the second Cu(II) ion (1997) (26)
Oligophenylenaminones as scaffolds for α-helix mimicry. (2011) (26)
Intramolecular hydrogen bonding allows simple enaminones to structurally mimic the i, i + 4, and i + 7 residues of an α-helix (2006) (26)
Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA. (2006) (25)
Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors. (1999) (25)
pH-dependent conformational switching in 2,6-benzamidodiphenylacetylenes. (2011) (25)
Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase‐1 inhibitor GGTI‐298 disrupts MAP kinase activation and G1‐S transition in Ki‐Ras‐overexpressing transformed adrenocortical cells (1999) (25)
Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics. (2012) (25)
Inhibition of chymotrypsin by a self-assembled DNA quadruplex functionalized with cyclic peptide binding fragments. (2009) (25)
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold. (2002) (25)
Use of proximity ligation to screen for inhibitors of interactions between vascular endothelial growth factor A and its receptors. (2008) (24)
Fiber formation by highly CO2-soluble bisureas containing peracetylated carbohydrate groups. (2007) (23)
Protein recognition using synthetic surface-targeted agents (2004) (23)
A Novel Class of meso-Tetrakis-Porphyrin Derivatives Exhibits Potent Activities against Hepatitis C Virus Genotype 1b Replicons In Vitro (2009) (23)
Complexation control of pericyclic reactions : supramolecular effects on the intramolecular diels : alder reaction (1991) (23)
New approaches to anticancer drug design based on the inhibition of farnesyltransferase (1998) (23)
Examination of the effect of the annealing cation on higher order structures containing guanine or isoguanine repeats. (2009) (23)
Molecular recognition and catalysis: Incorporation of an "oxyanion hole" into a synthetic receptor (1997) (23)
Noncovalent template-assisted mimicry of multiloop protein surfaces: assembling discontinuous and functional domains. (2012) (23)
Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation (2015) (22)
Cyclopiperazines: A new approach to chiral macrocyclic receptors☆ (1986) (22)
Small molecules in biology. (2011) (22)
Molecular recognition and catalysis; acceleration of acyl transfer reactions by a hydrogen-bonding receptor (1990) (22)
Signal transduction pathways of IL-1β-mediated iNOS in pulmonary vascular smooth muscle cells (2001) (21)
Contrasting effects of prenyltransferase inhibitors on estrogen-dependent cell cycle progression and estrogen receptor-mediated transcriptional activity in MCF-7 cells. (2003) (21)
New supramolecular arrays based on interactions between carboxylate and urea groups: solid-state and solution behavior (1998) (20)
Hydrogen bond controlled aggregation of guanidinium-carboxylate derivatives in the solid state (2002) (19)
Nucleotide base recognition: synthesis of artificial receptors containing two distinct binding regions for the complexation of bis-thymine derivatives (1990) (19)
Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver cancer cell lines. (2003) (19)
Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity. (2021) (19)
Burkitt lymphoma Daudi cells contain two distinct farnesyltransferases with different divalent cation requirements. (1995) (19)
Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle. (2000) (18)
Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics. (2007) (18)
Surface Binding Inhibitors of the SCF–KIT Protein–Protein Interaction (2009) (18)
Synthesis of a molecular receptor containing two recognition sites (1985) (18)
Synthetic Studies on Molecular Recognition (1991) (18)
CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase. (1995) (17)
Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. (2010) (17)
Recent developments in the identification of chemotherapeutics for Chagas disease. (2005) (17)
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells. (1998) (17)
Iron(III) complexes of chiral bipyridine macrocycles as novel metallo-catalysts (1987) (17)
Enhanced extraction of phenobarbital from serum with a designed artificial receptor. (1994) (17)
Synthetic Non‐Peptide Mimetics of α‐Helices (2007) (17)
Inhibition of geranylgeranyltransferase I decreases generation of vascular reactive oxygen species and increases vascular nitric oxide production. (2005) (17)
Chiral recognition of tartaric acid derivatives by a synthetic receptor (1991) (17)
Blocking HIV-1 entry by a gp120 surface binding inhibitor. (2012) (17)
Specific inhibition of flavin catalyses by a “molecular hinge” (1989) (16)
Model studies on the active site of cytochrome P-450 : an FeII–porphyrin carrying a strapped thiolate ligand (1982) (16)
Nucleotide recognition by macrocyclic receptors (1989) (16)
Molecular Recognition of Phosphate Esters: A Balance of Hydrogen Bonding and Proton Transfer Interactions (1992) (16)
Synthesis and structure of chiral macrocycles containing 2,2'-bipyridine subunits. (1996) (15)
Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein-protein interaction in C. hominis TS-DHFR. (2013) (15)
Self-assembly of a four-helix bundle on a DNA quadruplex. (2009) (15)
Tetracyanoresorcin[4]arene selectively recognises trimethyllysine and inhibits its enzyme-catalysed demethylation (2016) (15)
Mixed substrate supermolecules: binding of organic substrates and of metal ions to heterotopic coreceptors containing porphyrin subunits (1984) (15)
Functionalized oligoanthranilamides: modular and conformationally controlled scaffolds. (2001) (15)
Foldamer‐based Molecular Recognition (2007) (15)
Facile and selective aerobic oxidation of arylalkanes to aryl ketones using cesium carbonate (2006) (15)
Synthesis of tetrameric and hexameric cyclo-porphyrins (1987) (15)
Side chain elongation causes a change from enthalpy driven to entropy driven binding in the molecular recognition of tetraanionic peptides (2000) (14)
Design and Synthesis of Oligoamide-Based Double α-Helix Mimetics (2013) (14)
Hydrophobic side-chain interactions in a family of dimeric amide foldamers-potential alpha-helix mimetics (2011) (14)
Hydrogen bonding control of molecular self-assembly: Recent advances in design, synthesis, and analysis (1996) (14)
Design of a Protein Surface Antagonist Based on α-Helix Mimicry: Inhibition of gp41 Assembly and Viral Fusion We thank the National Institutes of Health for support of this work and the Deutsche Forschungsgemeinschaft (DFG) for a research fellowship to O.K. (2002) (14)
Novel 7-(dimethylamino)fluorene-based fluorescent probes and their binding to human serum albumin. (2009) (14)
Recognition of neutral species with synthetic receptors. (1997) (14)
Expedient route to functionalized and water soluble 5-6-5 imidazole-phenyl-thiazole based α-helix mimetics (2013) (13)
Altered binding of a multimeric protein by changing the self-assembling properties of its substrate. (2010) (13)
Electrochemical studies on molecular recognition of anions: Complex formation between xylylenyl bis-iminoimidazolinium and dicarboxylates in nitrobenzene and water (1998) (13)
Supramolecular dendrimers: convenient synthesis by programmed self-assembly and tunable thermoresponsivity. (2012) (13)
Development of a tripeptide mimetic strategy for the inhibition of protein farnesyltransferase (2000) (12)
Strong interactions in covalently trimeric porphyrins (1986) (12)
Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions. (2010) (12)
Inhibition of Rho GTPases using protein geranylgeranyltransferase I inhibitors. (2000) (11)
Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). (2005) (11)
Molecular recognition: Cyclobutane thymine diners as rigid two-site receptors (1990) (11)
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase. (2006) (10)
Towards a synthetic model of the structure of the photosynthetic reaction centre (1986) (10)
Rational design of Ras prenyltransferase inhibitors as potential anticancer drugs. (1996) (10)
Synthesis of the novel trimeric benzamides—potential inhibitors of protein–protein interactions (2012) (10)
Solvent and pH Effects on the Fluorescence of 7-(Dimethylamino)-2-Fluorenesulfonate (2007) (10)
Molecular design and bioorganic catalysis (1996) (10)
Anticancer activity of farnesyltransferase and geranylgeranyltransferase I inhibitors: prospects for drug development. (1997) (10)
Inhibitors of ras farnesyltransferase as novel antitumor agents (1995) (10)
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I. (2005) (9)
A Lewis acid-mediated conformational switch. (2014) (9)
Excited-state photophysics of donor-appended cobalt(II) porphyrins from picosecond transient absorption spectroscopy (1993) (9)
Mimicry of a β-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer. (2018) (9)
Hydrogen Bonding Aggregation of a Series of Bis-Amidinium Halide Salts in the Solid State (1999) (9)
Ferrochelatase: isolation and purification via affinity chromatography. (1980) (9)
Molecular recognition: Porphyrin containing receptors as analogs of barbiturate induced cytochrome P450 (1992) (9)
SYNTHESIS OF ARTIFICIAL RECEPTORS AS POTENTIAL CANDIDATES FOR RECOGNITION AND BINDING OF PTERIN ANALOGS (1995) (9)
Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates. (2009) (9)
A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics. (2015) (9)
Alpha‐Helix Mimetics in Drug Discovery (2006) (9)
Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor. (1998) (9)
A synthetic analogue of the carboxylate-binding pocket of vancomycin (1986) (9)
α-Helix-Mimetic Foldamers for Targeting HIV-1 TAR RNA. (2019) (9)
Enaminone-based mimics of extended and hydrophilic α-helices. (2012) (8)
X-ray crystal structures of bridged porphyrins (1980) (8)
Experimental Measurements of Low-Frequency Intermolecular Host−Guest Dynamics (1998) (8)
NIST programs for calibrations in the far ultraviolet spectral region (1999) (8)
Biosynthesis of porphyrins and related macrocycles. Part 13. Structure of the protoporphyrin isomer derived from coproporphyrinogen IV by the action of beef-liver coproporphyrinogenase: synthesis of protoporphyrin XIII. (1980) (8)
Isophthalic acid-derived organogelators (2002) (8)
Charge transfer in covalently-linked porphyrin-donor complexes from picosecond transient absorption spectroscopy (1993) (8)
Ultrafast energy transfer within pyropheophorbide-a tethered to self-assembling DNA quadruplex. (2010) (8)
Duplex DNA as a Self-Assembling Template for the Identification of Bidentate Protein-Binding Agents (2007) (8)
Benzoylurea oligomers: synthetic foldamers that mimic extended alpha helices. (2007) (8)
Redox-Dependent Conformational Switching of Diphenylacetylenes (2014) (8)
Remote conformational control of a molecular switch via methylation and deprotonation. (2014) (8)
Synthesis of a 2,3';6',3''-terpyridine scaffold as an alpha-helix mimetic. (2005) (8)
Protein Secondary Structure Mimetics as Modulators of Protein–Protein and Protein‐Ligand Interactions (2008) (8)
Molecular recognition. Design of new receptors for complexation and catalysis (1993) (8)
Constrained analogs of methionine: asymmetric synthesis of χ-angle restricted methionine derivatives through [3.1.0]-γ-lactone cyclopropane ring opening (2001) (7)
SURF II: Characteristics, facilities, and plans (1992) (7)
Synthesis and Biological Evaluation of a 5-6-5 Imidazole-Phenyl- Thiazole Based α-Helix Mimetic (2009) (7)
Supramolecular self-assembly based on directed hydrogen bonding (1993) (7)
Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen. (2013) (7)
An α-helical peptidomimetic scaffold for dynamic combinatorial library formation. (2017) (7)
Protein surface recognition by synthetic receptors (1999) (7)
The Guanidinium Group in Molecular Recognition: Design and Synthetic Approaches. (2002) (7)
Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation. (2015) (7)
Denaturation and accelerated proteolysis of sizeable heme proteins by synthetic metalloporphyrins (2007) (7)
Protein farnesyltransferase: Flexible docking studies on inhibitors using computational modeling (2006) (6)
Rationally designed helical peptidomimetics disrupt α-synuclein fibrillation. (2022) (6)
1-Phenyl-1H-pyrrole-2,5-dicarboxylic acid derivatives as versatile hydrogen-bonding motifs for the formation of one-, two- and three-dimensional networks in the solid state (1998) (6)
NOVEL CO2-THICKENERS FOR IMPROVED MOBILITY CONTROL (2001) (6)
Inhibitor GGTI-298 through a Transforming Growth Factor b- and Sp1-Responsive Element: Involvement of the Small GTPase RhoA (1998) (6)
Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents (2020) (6)
Inexpensive CO2 Thickening Agents for Improved Mobility Control of CO2 Floods (2005) (5)
Synthesis and binding studies of a 1-alkyl-3,6-diamino-4-quinolone based receptor for N-acylated dipeptides. (1998) (5)
SURF III—A new electron storage ring at NIST (2001) (5)
Heterofunctionalized Cavitands by Macrocyclization of Sequence-Defined Foldamers (2019) (5)
Signal transduction pathways of IL-1beta-mediated iNOS in pulmonary vascular smooth muscle cells. (2001) (5)
Molecular Recognition: Bis‐Acylguanidiniums Provide a Simple Family of Receptors for Phosphodiesters. (1992) (5)
Quantifying intrinsic ion-driven conformational changes in diphenylacetylene supramolecular switches with cryogenic ion vibrational spectroscopy. (2013) (5)
Prenyltransferase Inhibitors as Radiosensitizers (2001) (5)
Recent Advances in the Development of Aryl-Based Foldamers (2009) (4)
The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents. (2003) (4)
Acid-mediated topological control in a functionalized foldamer. (2016) (4)
Super-secondary structure peptidomimetics: design and synthesis of an α–α hairpin analogue (2013) (4)
Farnesyltransferase inhibitor R 115777 ( Zarnestra , Tipifarnib ) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells (2005) (4)
Cryo-Tem, X-Ray Diffraction and Modeling of an Organic Hydrogel (2006) (4)
Farnesyltransferase and Geranylgeranyltransferase I Inhibitors as Novel Agents for Cancer and Cardiovascular Diseases (2001) (4)
Protein – Protein Interactions Terphenyl-Based Helical Mimetics That Disrupt the p 53 / HDM 2 Interaction * * (2007) (4)
Cytotoxic Agents Cisplatin , Taxol , and Gemcitabine Geranylgeranyltransferase I : Combination Therapy with the Peptidomimetic Inhibitors of Farnesyltransferase and Antitumor Efficacy of a Novel Class of Non-thiol-containing Updated Version (1999) (4)
The conversion of SURF II to SURF III (1999) (4)
Hydrogen Bond Controlled Aggregation of Guanidinium-Carboxylate Derivatives in the Solid State. (2010) (4)
Selected programs at the new SURF III electron storage ring (2001) (4)
Corrigendum to “Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I” [Bioorg. Med. Chem. Lett. 17 (2007) 2639–2642] (2007) (4)
A Combinatorial Library Approach to Artificial Receptor Design. (1996) (4)
Unpicking the determinants of amide NHO[double bond, length as m-dash]C hydrogen bond strength with diphenylacetylene molecular balances. (2017) (4)
Teaching an old scaffold new recognition tricks: oligopyrrolamide antagonists of IAPP aggregation. (2018) (3)
v-Src transformation is mediated through farnesylated proteins. (2001) (3)
Hydrogen bonding in biological and artificial molecular recognition (1990) (3)
The design of artificial receptors for complexation and controlled aggregation (1993) (3)
Control of molecular aggregation by directed hydrogen bonding interactions (1994) (3)
Fiber formation in water by a mono-urea dicarboxylic acid. (2003) (3)
Protein surface recognition by porphyrin-based receptors (2004) (3)
Formation and Recognition Properties of Dynamic Combinatorial Libraries (2005) (2)
Farnesyltransferase inhibitors: Anti-Ras drugs for cancer treatment (1996) (2)
Antimicrobial Peptide Mimetics Based on a Diphenylacetylene Scaffold: Synthesis, Conformational Analysis, and Activity (2020) (2)
Inhibition of Protein-Protein Interactions by Peptide Mimics (2010) (2)
Receptors That Assemble Themselves (1997) (2)
Synthetic α -Helix Mimetics as Agonists and Antagonists of IAPP Amyloid Formation ** (2011) (2)
Controlled conformational changes in covalently-linked dimeric porphyrins (1985) (2)
Fluorescence sensing of anions (2003) (2)
Peptidomimetic-based inhibitors of farnesyltransferase (2001) (2)
Protein Recognition and Denaturation by Self‐Assembling Fragments on a DNA Quadruplex Scaffold. (2007) (2)
The Design of Organic Gelators: Solution and Solid State Properties of a Family of Bis-Ureas. (1998) (2)
An oxazole-based small-molecule stat3 inhibitor modulates stat3 stability and processing and induces antitumor cell effects (ACS Chemical Biology (2007) 2, (787-798)) (2009) (2)
Hydrogen bonding control of molecular self-assembly (1994) (2)
Host-guest chemistry: combinatorial receptors. (2003) (2)
Protein Surface Recognition (1999) (2)
ON THE FORMATION OF BILE PIGMENTS FROM HEME PROTEINS (1977) (2)
The helical supramolecular assembly of oligopyridylamide foldamers in aqueous media can be guided by adenosine diphosphates. (2021) (2)
Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity. (2022) (1)
SH3 Domains as Drug Targets (2013) (1)
Protein prenylation in trypanosomatids: A new piggy-back medicinal chemistry target for the development of agents against tropical diseases (2000) (1)
The design of organic gelators based on a family of bis-ureas (1999) (1)
Model systems — Artificial models of protein function (2001) (1)
Chemistry: Much binding in the lab (2002) (1)
The Impact of Perineural Invasion in Patients with Esophageal Adenocarcinoma Treated with Esophagectomy (2014) (1)
Molecular Recognition: A Remarkably Simple Receptor for the Selective Complexation of Dicarboxylic Acids. (2010) (1)
In recognition of proteins (2000) (1)
Plans for conversion of SURF II to SURF III (abstract) (1996) (1)
A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics. (2015) (1)
Editorial OverviewModel systemsEditorial overview (1999) (1)
Cancer Therapy : Preclinical Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB 2 Transgenic Mice (2011) (1)
Metal Template Control of Self‐Assembly in Supramolecular Chemistry (2007) (1)
Molecular Recognition in Biomimetic Receptors (2016) (1)
Cover Picture: Diphenylacetylene‐Linked Peptide Strands Induce Bidirectional β‐Sheet Formation (Angew. Chem. Int. Ed. 14/2014) (2014) (1)
An oxazole-based small-molecule Stat3 inhibitor induces Stat3 aggresome formation and antitumor cell effects (2008) (1)
Molecular Recognition of Biologically Interesting Substrates: Synthesis of an Artificial Receptor for Barbiturates Employing Six Hydrogen Bonds. (1988) (1)
New Synthetic Receptors for Complexation and Catalysis (1992) (1)
Molecular Recognition by Macrocyclic Receptors (1990) (1)
Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an alpha-helical conformation. (1997) (1)
Molecular recognition: Synthetic approaches to artificial receptors (1999) (1)
Cyclopiperazines: A New Approach to Chiral Macrocyclic Receptors. (1986) (1)
Design of artificial receptors for biochemically interesting substrates (1989) (1)
Inhibition of Zinc-Mediated Amyloid Beta Aggregation and Cytotoxicity by Alpha Helix Mimetics (2019) (1)
Facile and Selective Aerobic Oxidation of Arylalkanes to Aryl Ketones Using Cesium Carbonate. (2007) (1)
Reactivity of Lithium Tetrahydridoberyllate Towards Common Functional Groups: Scope and Limitations (1990) (1)
Synthesis of a Molecular Receptor Containing Two Recognition Sites. (1986) (1)
1,3‐Dicyclohexylcarbodiimide (2010) (1)
Strong interactions in covalently stacked trimeric porphyrins (1986) (1)
π-Acceptor macrocycles: new crown ethers containing isocyanide groups (1985) (1)
Synthetic analogs of peptide-binding antibiotics (1987) (1)
Aromatic Analogues of Arcaine Inhibit MK-801 Binding to the NMDA Receptor. (1999) (0)
Reactivity of Lithium Tetrahydridoberyllate Towards Common Functional Groups: Scope and Limitations. (1990) (0)
Constrained Analogues of Methionine: Asymmetric Synthesis of χ-Angle Restricted Methionine Derivatives Through [3.1.0]-γ-Lactone Cyclopropane Ring Opening. (2001) (0)
547 POSTER Novei small-molecule inhibitors of STAT3 that selectively induce antitumor cell activity (2006) (0)
BIOSYNTHESIS OF PORPHYRINS AND RELATED MACROCYCLES. PART 13. STRUCTURE OF THE E PROTOPORPHYRIN ISOMER DERIVED FROM COPROPORPHYRINOGEN IV BY THE ACTION OF BEEF-LIVER COPROPORPHYRINOGENASE: SYNTHESIS OF PROTOPORPHYRIN XIII (1980) (0)
Synthesis and Binding Studies of a 1‐Alkyl‐3,6‐diamino‐4‐quinolone Based Receptor for N‐Acylated Dipeptides. (1998) (0)
444 DEVELOPMENT OF NEW DRUGS FOR CHAGAS DISEASE. (2006) (0)
Strategies for Targeting Protein—Protein Interactions with Synthetic Agents (2005) (0)
Recognition of cytochrome C by tetraphenylporphyrin-based protein surface receptors (2005) (0)
Prenyltransferase inhibitors as radiosensitizing agents for tumor cells with activated ras (1998) (0)
Coreceptor Molecules. Synthesis of Metalloreceptors Containing Porphyrin Subunits and Formation of Mixed Substrate Supermolecules by Binding of Organic Substrates and of Metal Ions. (1986) (0)
33 In vivo radiosensitization of human tumors expressing mutant ras by farnesyltransferase inhibitors (1999) (0)
Synthesis of Tetrameric and Hexameric Cyclo-Porphyrins. (1987) (0)
A Synthetic Analogue of the Carboxylate-Binding Pocket of Vancomycin. (1986) (0)
Supplemental Information Allosteric Activation Dictates PRC 2 Activity Independent of Its Recruitment to Chromatin (2018) (0)
Abstract 3088: Farnesyl/geranylgeranyl transferase dual inhibitor thwarts mutant KRas-driven patient-derived pancreatic tumors (2019) (0)
INEXPENSIVE CO{sub 2} THICKENING AGENTS FOR IMPROVED MOBILITY CONTROL OF CO{sub 2} FLOODS (2004) (0)
General aspects of protein prenylation The importance of FT and GGT 1 for normal physiology and tumorigenesis : lessons from knockout mice (2014) (0)
Controlled formation & properties of responsive polymers (1992) (0)
Profile. Andrew D. Hamilton. (2003) (0)
Carboxylic Acid Complexation by a Synthetic Analogue of the “Carboxylate-Binding Pocket” of Vancomycin. (1988) (0)
Peptidomimetic inhibitors of farnesyltransferase (1997) (0)
Oligophenylenaminones as Scaffolds for r-Helix Mimicry (2011) (0)
Single-molecule nanopore dielectrophoretic trapping of α-Synuclein with lipid membranes (2022) (0)
Formation of Artificial Receptors by Metal-Templated Self-Assembly (1997) (0)
Synthetic porphyrins containing adjacent, redox-active species models of biological electron transfer sites (1985) (0)
Organic Materials that Respond to Molecules (1993) (0)
ISOLATION OF ION-DRIVEN CONFORMATIONS IN DIPHENYLACETYLENE MOLECULAR SWITCHES USING CRYOGENIC INFRARED SPECTROSCOPY (2012) (0)
Abstract 3675: Farnesyltransferase inhibitor (FTI) disruption of Rheb/FKBP38 association leads to FKBP38-mediated inactivation of mTOR (2010) (0)
H-Ras Transgenic Mice Breast Carcinoma Apoptosis and Tumor Regression in Geranylgeranyltransferase I Inhibitor GGTI-2154 Induces (2003) (0)
Nucleotide Base Recognition: Synthesis of Artificial Receptors Containing Two Distinct Binding Regions for the Complexation of Bisthymine Derivatives. (1990) (0)
CCDC 849194: Experimental Crystal Structure Determination (2013) (0)
Growth Factor Antagonism in Breast Cancer Chemotherapy (2002) (0)
Affinity chromatography : variations on a heme (1976) (0)
Corrigendum to “Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: Structural recognition of STAT SH2 domains” [Bioorg. Med. Chem. Lett. 17 (2007) 1875–1878] (2007) (0)
Erratum - Constrained analogs of methionine: Asymmetric synthesis of χ-angle restricted methionine derivatives through [3.1.0]-γ-lactone cyclopropane ring opening (Tetrahedron Letters (2001) 42 (211-213) PII: S0040403900019122) (2001) (0)
Application of a concept drawn from two areas of macromolecular chemistry shows how artificial binding sites that resemble those found in globular proteins can be made (0)
Protein Prenylation in Trypanosomatids (2001) (0)
Rheb requires a farnesyl or geranylgeranyl to bind to mTOR: implications for FTI antitumor activity (2007) (0)
Peptidomimetic inhibitors of farnesyltransferase: An approach to new antitumor agents (1997) (0)
Inhibitors of Stat3 (US) (2015) (0)
Complexation control of pericyclic reactions: supramolecular effects on the intramolecular Diels-Alder reaction [Erratum to document cited in CA114(3):23229t] (1991) (0)
Cover Picture: A Modular Synthesis of Conformationally Preorganised Extended β‐Strand Peptidomimetics (Chem. Eur. J. 42/2015) (2015) (0)
1,3‐Dicyclohexylcarbodiimide–4‐Dimethylaminopyridine (2001) (0)
Inhibition of protein geranylgeranylation requires p27kip1 to induce human breast cancer cell death (2007) (0)
Chapter 6 – Geranylgeranyltransferase-1 Inhibitors (2011) (0)
Self-assembling structures based on hydrogen bonding subunits (1999) (0)
Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity (2022) (0)
In vitro analysis of inhibition of interactions of VEGF-A and its receptors by proximity ligation (2006) (0)
CHAPTER 1. Supramolecular Approaches to Protein Recognition (2020) (0)
Synthesis Approaches to Analogues of the Vancomycin Family of Antibiotics (1986) (0)
Self-assembly as a strategy for artificial receptor design (1996) (0)
Effects of rigid analogs of arcaine on the polyamine site of the NMDA receptor complex (1994) (0)
Cumulative Title Index (1996) (0)
CCDC 806307: Experimental Crystal Structure Determination (2011) (0)
Cover Feature: α‐Helix‐Mimetic Foldamers for Targeting HIV‐1 TAR RNA (Chem. Eur. J. 30/2019) (2019) (0)
Improving Structural Stability and Anticoagulant Activity of a Thrombin Binding Aptamer by Aromatic Modifications (2022) (0)
Preoperative testing. Author's reply (2006) (0)
CCDC 849443: Experimental Crystal Structure Determination (2013) (0)
Volume Contents (2004) (0)
CCDC 849444: Experimental Crystal Structure Determination (2013) (0)
Cumulative Author Index (1996) (0)
Towards artificial antibodies: Protein surface recognition by synthetic receptors (2002) (0)
At a calixarene attached growth factor binding compounds (2005) (0)
Abstract 620: Development of a dual protein farnesyltransferase -geranylgeranyltransferase-I inhibitor with antitumor activity against human cancer cells (2011) (0)
Oligopyridylamide-based protein mimetic inhibits cancer-associated mutant p53 amyloid-like aggregation and restores its tumor suppressor function (2022) (0)
Optimization of Diarylamines as Non‐Nucleoside Inhibitors of HIV‐1 Reverse Transcriptase. (2006) (0)
A Dual Channel Fluorescence Chemosensor for Anions Involving Intermolecular Excited State Proton Transfer We thank the National Institutes of Health for financial support of this work. (2001) (0)
CCDC 849442: Experimental Crystal Structure Determination (2013) (0)
Nucleotide Base Recognition: A Macrocyclic Receptor for Adenine Employing Hydrogen Bonding and Aromatic Stacking Interactions. (1989) (0)
Book review (1994) (0)
Peptide and Protein Recognition by Designed Molecules (2000) (0)
Molecular Recognition of Phosphate Esters: A Balance of Hydrogen Bonding and Proton Transfer Interactions. (1993) (0)
Intra- and Intermolecular Hydrogen Bonding Control of Supramolecular Structure (1994) (0)
Molecular recognition: Preface (1995) (0)
Organogelators: New supramolecular materials (2002) (0)
Design and Synthesis of Oligoamide‐Based Double α‐Helix Mimetics (Eur. J. Org. Chem. 17/2013) (2013) (0)
Nitrogen-containing bisphosphonates induce apoptosis in human bone marrow-derived myeloma cells in vitro by inhibiting protein prenylation. (1999) (0)
Abstract B35: Dual inhibitors of FT and GGT-1 as novel therapeutic agents for K-Ras-dependent tumors (2014) (0)
Geranylgeranyltransferase I inhibitors induce p27 accumulation and G1 arrest in human breast cancer cell lines independently of Rb status and expression levels of Erb1, 2, 3 and 4 (2004) (0)
Peptides and molecular recognition: head-to-tail self-assembly, formation of amphipathic surfaces and recognition of anionic superhelices (1999) (0)
Induced Fit in Synthetic Receptors: Nucleotide Base Recognition by a “Molecular Hinge”. (1987) (0)
Novel CO{sub 2}-thickeners for improved mobility control (2000) (0)
A Versatile One-Pot Synthesis of 1,3-Substituted Guanidines from Carbamoyl Isothiocyanates. (2000) (0)
Directed hydrogen bonding in the design of new receptors for complexation and catalysis (1992) (0)
An Anion-Dependent Switch (2011) (0)
Modulation of the hypoxic response in cancer; inhibition of the HIF-1α/p300 protein-protein interaction (2014) (0)
STAT3 inhibitor having anti-cancer activity and methods (US) (2020) (0)
Kinase Signal Pathway Ras-Independent Mitogen-Activated Protein Direct Tumor Lysis by NK Cells Uses a (2000) (0)
Signal transduction pathways of IL-1 b -mediated iNOS in pulmonary vascular smooth muscle cells (2001) (0)
Chapter 20 CRYO-TEM , X-RAY DIFFRACTIONAND MODELINGOFAN ORGANIC HYDROGEL (0)
Abstract #3656: The BH3 alpha helical mimic BH3M-6 disrupts Bcl-xL/Bax and Mcl-1/Bax binding and induces apoptosis in human cancer cells in a Bcl-xL, Bcl2 and Mcl-1 dependent manner. (2009) (0)
Titelbild: Diphenylacetylene‐Linked Peptide Strands Induce Bidirectional β‐Sheet Formation (Angew. Chem. 14/2014) (2014) (0)
Self-Assembling Peptide Systems in Biology, Medicine and Engineering Edited by Amalia Aggeli, Neville Boden (University of Leeds, U.K.), and Shuguang Zhang (Massachusetts Institute of Technology). Kluwer Acedemic Publishers: Dordrecht, Boston, London. 2001. xii + 364 pp. $100.00. ISBN 0-7923-7090-2. (2002) (0)

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