Andrew Leask
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Researcher ORCID ID = 0000-0003-2832-283X
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(Suggest an Edit or Addition)Andrew Leask's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- TGF‐β signaling and the fibrotic response (2004) (1969)
- All in the CCN family: essential matricellular signaling modulators emerge from the bunker (2006) (641)
- Potential Therapeutic Targets for Cardiac Fibrosis: TGF&bgr;, Angiotensin, Endothelin, CCN2, and PDGF, Partners in Fibroblast Activation (2010) (580)
- CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling* (2001) (433)
- Alopecia universalis associated with a mutation in the human hairless gene. (1998) (413)
- Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. (2004) (378)
- Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. (2008) (354)
- Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? (2002) (345)
- Getting to the heart of the matter: new insights into cardiac fibrosis. (2015) (294)
- The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. (2003) (272)
- Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair (2012) (264)
- Tumor Necrosis Factor α Suppresses the Induction of Connective Tissue Growth Factor by Transforming Growth Factor-β in Normal and Scleroderma Fibroblasts* (2000) (262)
- TGFβ, cardiac fibroblasts, and the fibrotic response (2007) (243)
- Connective Tissue Growth Factor Gene Regulation (2003) (239)
- Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. (2009) (233)
- CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. (2002) (224)
- Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis (2002) (215)
- Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients. (2001) (213)
- Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. (2010) (199)
- Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis. (2000) (193)
- Endothelin-1 Induces Expression of Matrix-associated Genes in Lung Fibroblasts through MEK/ERK* (2004) (176)
- CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. (2004) (173)
- Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. (2007) (169)
- Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease? (2009) (162)
- CCN2 Is Necessary for Adhesive Responses to Transforming Growth Factor-β1 in Embryonic Fibroblasts* (2006) (159)
- TGFbeta, cardiac fibroblasts, and the fibrotic response. (2007) (157)
- Constitutive ALK5-Independent c-Jun N-Terminal Kinase Activation Contributes to Endothelin-1 Overexpression in Pulmonary Fibrosis: Evidence of an Autocrine Endothelin Loop Operating through the Endothelin A and B Receptors (2006) (153)
- Prostacyclin derivatives prevent the fibrotic response to TGFβ2 by inhibiting the Ras/MEK/ERK pathway (2002) (152)
- Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice (2015) (149)
- Expression of integrin β1 by fibroblasts is required for tissue repair in vivo (2010) (147)
- CCN2 is required for bleomycin-induced skin fibrosis in mice. (2011) (145)
- Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. (2012) (144)
- Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease. (2005) (139)
- Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma. (2004) (137)
- Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts (2004) (136)
- FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype. (2007) (136)
- Curcumin prevents and reverses murine cardiac hypertrophy. (2008) (136)
- Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair (2012) (129)
- The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts (2001) (123)
- Targeting the TGFbeta, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma. (2008) (123)
- Constitutive Connective Tissue Growth Factor Expression in Scleroderma Fibroblasts Is Dependent on Sp1* (2003) (112)
- Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts. (2002) (111)
- N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma. (2005) (111)
- TGF-b signaling in cartilage homeostasis and osteoarthritis. (2012) (110)
- Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. (2007) (108)
- Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis. (2010) (106)
- CCN2 is necessary for the function of mouse embryonic fibroblasts. (2007) (98)
- Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts. (2006) (89)
- Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model. (2009) (87)
- The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. (2006) (80)
- Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome. (2001) (78)
- Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts. (2009) (78)
- Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis. (2009) (77)
- Mechanical Tension Increases CCN2/CTGF Expression and Proliferation in Gingival Fibroblasts via a TGFβ-Dependent Mechanism (2011) (77)
- Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer. (2008) (75)
- Loss of PTEN expression by dermal fibroblasts causes skin fibrosis. (2011) (75)
- The induction of CCN2 by TGFβ1 involves Ets-1 (2006) (73)
- Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling (2015) (72)
- Transcriptional profiling of the scleroderma fibroblast reveals a potential role for connective tissue growth factor (CTGF) in pathological fibrosis. (2004) (69)
- Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2. (2013) (67)
- GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. (2008) (65)
- Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex (2017) (64)
- Signaling in fibrosis: targeting the TGF beta, endothelin-1 and CCN2 axis in scleroderma. (2009) (63)
- Rac1 expression by fibroblasts is required for tissue repair in vivo. (2009) (62)
- Connective tissue growth factor and integrin αvβ6: A new pair of regulators critical for ductular reaction and biliary fibrosis in mice (2015) (62)
- Activation of Key Profibrotic Mechanisms in Transgenic Fibroblasts Expressing Kinase-deficient Type II Transforming Growth Factor-β Receptor (TβRIIΔk)* (2005) (61)
- Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis (2017) (60)
- Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts. (2010) (58)
- Conditional β1‐integrin‐deficient mice display impaired pancreatic β cell function (2011) (58)
- The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts (2007) (57)
- Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ (2018) (56)
- Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts (2009) (55)
- Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis. (2017) (55)
- β1 integrin–extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function (2013) (53)
- Targeting the extracellular matrix: matricellular proteins regulate cell-extracellular matrix communication within distinct niches of the intervertebral disc. (2014) (52)
- Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFα-induced MEK/ERK signalling (2009) (51)
- Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts. (2012) (51)
- Connective tissue growth factor promoter activity in normal and wounded skin (2008) (51)
- Scar wars: is TGFβ the phantom menace in scleroderma? (2006) (50)
- Towards an anti-fibrotic therapy for scleroderma: targeting myofibroblast differentiation and recruitment (2010) (50)
- Connective tissue growth factor is induced in bleomycin-induced skin scleroderma (2009) (49)
- Gingival Fibroblasts Display Reduced Adhesion and Spreading on Extracellular Matrix: A Possible Basis for Scarless Tissue Repair? (2011) (48)
- Rac1 signaling regulates CTGF/CCN2 gene expression via TGFbeta/Smad signaling in chondrocytes. (2009) (48)
- Focal Adhesion Kinase/Src Suppresses Early Chondrogenesis (2008) (46)
- Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma. (2018) (46)
- Focal Adhesion Kinase: A Key Mediator of Transforming Growth Factor Beta Signaling in Fibroblasts. (2013) (46)
- Fibroblast adhesion results in the induction of a matrix remodeling gene expression program. (2008) (45)
- Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor. (2011) (44)
- The Matrix Revolution: Matricellular Proteins and Restructuring of the Cancer Microenvironment (2020) (43)
- Integrin β1: A Mechanosignaling Sensor Essential for Connective Tissue Deposition by Fibroblasts. (2013) (41)
- Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts. (2008) (40)
- Activation of the Connective Tissue Growth Factor (CTGF)-Transforming Growth Factor β 1 (TGF-β 1) Axis in Hepatitis C Virus-Expressing Hepatocytes (2012) (39)
- Lefty Contributes to the Remodeling of Extracellular Matrix by Inhibition of Connective Tissue Growth Factor and Collagen mRNA Expression and Increased Proteolytic Activity in a Fibrosarcoma Model* (2002) (39)
- Src kinase inhibition promotes the chondrocyte phenotype (2007) (38)
- Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism (2011) (38)
- Loss of PPARγ expression by fibroblasts enhances dermal wound closure (2012) (37)
- A centralized communication network: Recent insights into the role of the cancer associated fibroblast in the development of drug resistance in tumors. (2019) (36)
- Synaptically coupled central nervous system neurons lack centrosomal γ-tubulin (1997) (36)
- CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload. (2015) (34)
- Loss of PTEN expression by mouse fibroblasts results in lung fibrosis through a CCN2-dependent mechanism. (2015) (34)
- Fibrosis caused by loss of PTEN expression in mouse fibroblasts is crucially dependent on CCN2. (2013) (33)
- Skin Progenitor Cells Contribute to Bleomycin‐Induced Skin Fibrosis (2014) (33)
- Genetic manipulation of CCN2/CTGF unveils cell‐specific ECM‐remodeling effects in injured skeletal muscle (2018) (32)
- The role of endothelin-1 signaling in the fibrosis observed in systemic sclerosis. (2011) (32)
- Role of Rac1 in a bleomycin-induced scleroderma model using fibroblast-specific Rac1-knockout mice. (2008) (32)
- Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells (2008) (32)
- CCN2 expression by fibroblasts is not required for cutaneous tissue repair (2014) (31)
- miR-218 regulates focal adhesion kinase–dependent TGFβ signaling in fibroblasts (2014) (31)
- Loss of protein kinase Cϵ results in impaired cutaneous wound closure and myofibroblast function (2008) (31)
- CCN2 Expression by Tumor Stroma Is Required for Melanoma Metastasis. (2015) (30)
- Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK (2007) (30)
- Conditional knockout of CTGF affects corneal wound healing. (2014) (29)
- Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts (2017) (29)
- Possible strategies for anti-fibrotic drug intervention in scleroderma (2011) (27)
- Inflammatory microenvironment and tumor necrosis factor alpha as modulators of periostin and CCN2 expression in human non-healing skin wounds and dermal fibroblasts. (2015) (27)
- Conjunction junction, what's the function? CCN proteins as targets in fibrosis and cancers. (2020) (26)
- CCN2: a novel, specific and valid target for anti-fibrotic drug intervention (2013) (26)
- ALK5 Inhibition Blocks TGFβ-induced CCN2 Expression in Gingival Fibroblasts (2010) (25)
- Getting Out of a Sticky Situation: Targeting the Myofibroblast in Scleroderma (2012) (25)
- Synaptically coupled central nervous system neurons lack centrosomal gamma-tubulin. (1997) (24)
- TAK1 is required for dermal wound healing and homeostasis. (2013) (24)
- TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma (2017) (24)
- Why target the tumor stroma in melanoma? (2018) (24)
- Matrix remodeling in systemic sclerosis (2015) (24)
- mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis (2011) (23)
- Thrombospondin 1 in hypoxia-conditioned media blocks the growth of human microvascular endothelial cells and is increased in systemic sclerosis tissues (2011) (23)
- Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-β2 in fibroblasts. Vol. 278 (2003) 13008–13015 (2005) (22)
- Pericytes display increased CCN2 expression upon culturing (2009) (21)
- Integrin β1 is required for dermal homeostasis. (2013) (21)
- Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2 (2009) (20)
- Targeting the jagged/notch pathway: a new treatment for fibrosis? (2010) (20)
- CCN2 modulates hair follicle cycling in mice (2013) (20)
- Integrin β1 is necessary for the maintenance of corneal structural integrity. (2011) (18)
- Endothelin receptor selectivity: evidence from in vitro and pre‐clinical models of scleroderma (2009) (17)
- Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts (2019) (17)
- Expression of Amino- and Carboxyl-terminal γ- and α-Tubulin Mutants in Cultured Epithelial Cells* (1998) (16)
- Cell–matrix interactions governing skin repair: matricellular proteins as diverse modulators of cell function (2015) (15)
- CCN1: a novel target for pancreatic cancer (2011) (15)
- CCN2 expression and localization in melanoma cells (2011) (15)
- CCN2 is not required for skin development (2011) (14)
- Insights into Fibroblast Plasticity: CCN2 Is Required for Activation of Cancer-Associated Fibroblasts in a Murine Model of Melanoma. (2019) (14)
- Emerging targets for the treatment of scleroderma (2012) (14)
- Targeting the annulus fibrosus of the intervertebral disc: Col1a2-Cre(ER)T mice show specific activity of Cre recombinase in the outer annulus fibrosus (2016) (14)
- Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2-Dependent Mechanism in Polycystic Kidney Disease. (2020) (13)
- Monitoring Collagen Synthesis in Fibroblasts Using Fluorescently Labeled tRNA Pairs (2014) (12)
- Yin and Yang revisited: CCN3 as an anti-fibrotic therapeutic? (2015) (12)
- CCN2 is required for recruitment of Sox2-expressing cells during cutaneous tissue repair (2015) (12)
- Verteporfin inhibits the persistent fibrotic phenotype of lesional scleroderma dermal fibroblasts (2021) (12)
- Matrix Contraction by Dermal Fibroblasts Requires Transforming Growth Factor-β/Activin-Linked Kinase 5, Heparan Sulfate-Containing Proteoglycans, and MEK/ERK (2005) (11)
- Mithramycin reduces expression of fibro‐proliferative mRNAs in human gingival fibroblasts (2011) (11)
- Periostin and CCN2 Scaffolds Promote the Wound Healing Response in the Skin of Diabetic Mice. (2019) (11)
- CCN2 in Skin Fibrosis. (2017) (11)
- 5Z-7-Oxozeanol Inhibits the Effects of TGFβ1 on Human Gingival Fibroblasts (2015) (10)
- CCN2: a bona fide target for anti-fibrotic drug intervention (2011) (10)
- Yin and Yang Part Deux: CCN5 inhibits the pro-fibrotic effects of CCN2 (2010) (9)
- ALK5 inhibition blocks TGFβ-induced CCN1 expression in human foreskin fibroblasts (2014) (9)
- The Contribution of Peroxisome Proliferator-Activated Receptor Gamma to Cutaneous Wound Healing. (2013) (9)
- COVID-19: is fibrosis the killer? (2020) (9)
- CCN1 expression by fibroblasts is required for bleomycin-induced skin fibrosis (2019) (9)
- CTGF(CCN2) is essential for fibroblast function (2006) (8)
- Sonic advance: CCN1 regulates sonic hedgehog in pancreatic cancer (2013) (8)
- Will o’ the wisp: CCN4 as a novel molecular target in osteoarthritis (2011) (8)
- CCN 3 INHIBITS THE PRO-FIBROTIC EFFECTS OF CCN 2 (2009) (8)
- The Starbuck stops here: it’s a Smad world (2008) (7)
- Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes. (2009) (7)
- Toward personalized medicine in scleroderma: classification of scleroderma patients into stable "inflammatory" and "fibrotic" subgroups. (2012) (7)
- A sticky situation: CCN1 promotes both proliferation and apoptosis of cancer cells (2009) (7)
- A tale of two orgins: do myofibroblasts originate from different sources in wound healing and fibrosis? (2016) (7)
- Thrombin-induced CCN2 expression as a target for anti-fibrotic therapy in scleroderma (2009) (6)
- Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of Ccn2 (2020) (6)
- Activation of latent TGFβ by αvβ1 integrin: of potential importance in myofibroblast activation in fibrosis (2014) (6)
- MEK/ERK inhibitors: proof-of-concept studies in lung fibrosis (2012) (6)
- The hard problem: Mechanotransduction perpetuates the myofibroblast phenotype in scleroderma fibrosis (2021) (6)
- Breathe, breathe in the air: the anti-CCN2 antibody pamrevlumab (FG-3019) completes a successful phase II clinical trial for idiopathic pulmonary fibrosis (2019) (6)
- Loss of protein kinase C&egr; results in impaired cutaneous wound closure and myofibroblast function (2014) (6)
- When there’s smoke there’s…scleroderma: evidence that patients with scleroderma should stop smoking (2011) (5)
- CCN6 (WISP3): a new anti-cancer therapy? (2010) (5)
- B cell block: is rituximab a new possible treatment for systemic sclerosis? (2010) (5)
- Correction: mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis (2011) (5)
- Sticking it to Scleroderma: Potential Therapies Blocking Elevated Adhesive and Contractile Signaling (2010) (4)
- Death of a tumor: targeting CCN in pancreatic cancer (2009) (4)
- When there’s smoke there’s.....CCN2 (2010) (4)
- Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy (2009) (4)
- Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes (2021) (4)
- CCN2: a mechanosignaling sensor modulating integrin-dependent connective tissue remodeling in fibroblasts? (2013) (4)
- Corrigendum to “CCN2 is necessary for the function of mouse embryonic fibroblasts” [Exp. Cell Res. 313 (2007) 952–964] (2007) (4)
- Trial by CCN2: a standardized test for fibroproliferative disease? (2009) (4)
- CCN2/decorin interactions: a novel approach to combating fibrosis? (2011) (4)
- Integrin β1 is required for maintenance of vascular tone in postnatal mice (2012) (4)
- CCN3: A novel function in vivo (2007) (4)
- It’s a knockout: CCN3 suppresses neointimal thickening (2010) (4)
- YANG PART DEUX CCN 5 INHIBITS THE PRO-FIBROTIC EFFECTS OF CCN 2 (2010) (3)
- CCN6: a modulator of breast cancer progression (2016) (3)
- CCN3: a novel anti-fibrotic treatment in end-stage renal disease? (2012) (3)
- Report on the 7th international workshop on the CCN family of genes (2014) (3)
- Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element (2009) (3)
- ENDOTHELIN-1 PROMOTES MYOFIBROBLAST INDUCTION THROUGH THE ETA RECEPTOR VIA RAC/PI3 KINASE/AKT AND CONTRIBUTES TO THE CONTRACTILE PHENOTYPE OF SCLERODERMA FIBROBLASTS (2004) (3)
- Studying the CCN Proteins in Fibrosis. (2017) (3)
- Matrix contraction by dermal fibroblasts requires syndecan 4: Insights into pathological scarring in chronic fibrotic disease (2006) (3)
- Curcumin prevents and reverses murine cardiac hypertrophy. (2009) (3)
- Eureka! Ets a target for fibrosis! (2011) (3)
- CCN2 YAPs at cancer (2008) (3)
- CCN6: a novel method of aTAKing cancer (2013) (3)
- Do drugs that target mTOR generate CCN2-mediated fibrogenic side effects? (2019) (3)
- Report on the 10th international workshop on the CCN family of genes October 21–24, 2019, Niagara Falls, Canada (2020) (2)
- Collagen type XIX regulates cardiac extracellular matrix structure and ventricular function (2022) (2)
- Slow train coming: an anti-CCN2 strategy reverses a model of chronic overuse muscle fibrosis (2020) (2)
- What’s in an intron? CCN1 mRNA splicing in cancer (2009) (2)
- Ceramide inhibits CCN2 expression in fibroblasts (2008) (2)
- Connective tissue growth factor (CTGF) and fibrosis (2002) (2)
- Egr-ly awaiting a “personalized medicine” approach to treat scleroderma (2012) (2)
- Loss of protein kinase C epsilon results in impaired cutaneous wound closure and myofibroblast function (vol 121, pg 3459, 2008) (2014) (2)
- Conditional Knockout of the β1 Integrin affects Glucose Metabolism and Pdx-1 Expression through ERK1/2 Signaling (2008) (2)
- Connective tissue growth factor (CTGF) mediates extracellular matrix deposition in bleomycin-induced lung fibrosis via the MEK/ERK signaling pathways. (2003) (2)
- Basic (PS01–PS58) (2012) (1)
- Hijacking ZIP codes: posttanscriptional regulation of CCN2 by nucleophosmin (2009) (1)
- Upregulation of Id1 and Id3 expression in lung fibrosis (2008) (1)
- Andrew Leask CCN 2 , and PDGF , Partners in Fibroblast Activation , Angiotensin , Endothelin , β Potential Therapeutic Targets for Cardiac Fibrosis : TGF (2010) (1)
- Report on the 9th international workshop on the CCN family of genes, November 2–7, 2017, Saint-Malo, France (2018) (1)
- 238. CCN1 Expression By Fibroblasts is Required for Bleomycin-Induced Skin Scleroderma (2015) (1)
- Genetic analysis of CTGF as an effector of TGFβ signaling and cardiac (2015) (1)
- The skinny on CCN2 (2008) (1)
- JCCS-A journal for translational research (2010) (1)
- COVID-19: is fibrosis the killer? (2020) (1)
- EPITHELIAL-TO-MESENCHYMAL TRANSITION AND LUNG FIBROSIS (2012) (1)
- BHPR research: qualitative1. Complex reasoning determines patients’ perception of outcome following foot surgery in rheumatoid arhtritis (2012) (1)
- Sp1king out cancer (....and fibrosis?) (2012) (1)
- Protein kinase c epsilon is required for cutaneous wound closure and myofibroblast formation (2007) (1)
- Report on the 7(th) international workshop on the CCN family of genes : October 16-19, 2013-Nice, France. (2014) (1)
- Erratum to: Thrombospondin 1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism (2015) (1)
- TAK1 EXPRESSION BY FIBROBLASTS IS REQUIRED FOR FIBROGENIC RESPONSES IN VIVO AND IN VITRO (2012) (1)
- TGF beta-INDUCED alpha-SMOOTH MUSCLE ACTIN EXPRESSION AND EXTRACELLULAR MATRIX CONTRACTION IN FIBROBLASTS REQUIRES TAK1 (2009) (1)
- Embryonic Protein NODAL Regulates the Breast Tumour Microenvironment by Reprogramming Cancer-Derived Secretomes (2020) (1)
- A NOVEL ANTI-FIBROTIC TREATMENT IN END-STAGE RENAL DISEASE ? (2012) (1)
- Meeting report: novel targets for cancer and connective tissues diseases (2011) (1)
- Yay team!: 5.782 (2021) (1)
- A tale of two orgins: do myofibroblasts originate from different sources in wound healing and fibrosis? (2016) (0)
- Abstract PO028: Embryonic protein NODAL as a potential modulator of the tumour microenvironment: Breast cancer secretome reprogramming and fibroblast activation (2021) (0)
- Using the Bleomycin-Induced Model of Fibrosis to Study the Contribution of CCN Proteins to Scleroderma Fibrosis. (2023) (0)
- Report on the 7th international workshop on the CCN family of genes (2014) (0)
- Integrin β1 is required for maintenance of vascular tone in postnatal mice (2012) (0)
- Sp1king out cancer (....and fibrosis?) (2011) (0)
- GSK-3b in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1– dependent mechanism (2018) (0)
- CELL SIGNALLING AND APOPTOSIS (2014) (0)
- CCN6: a novel method of aTAKing cancer (2013) (0)
- Do drugs that target mTOR generate CCN2-mediated fibrogenic side effects? (2019) (0)
- Bosentan alleviates the pro-fibrotic phenotype of lung scleroderma fibroblasts: Implications for treatment of scleroderma. (2005) (0)
- Connective tissue growth factor deficiency in adult articular cartilage promotes cartilage degeneration at early timepoints in mouse posttraumatic osteoarthritis (2016) (0)
- Thrombospondin 1 is a key mediator of TGF beta-mediated cell contractility in systemic sclerosis via a MEK/ERK-dependent mechanism (2009) (0)
- Matrix contraction by scleroderma fibroblasts requires TGF beta receptor ALK5, ras/MEK/ERK and syndecan 4 (2006) (0)
- Verteporfin inhibits the persistent fibrotic phenotype of lesional scleroderma dermal fibroblasts (2021) (0)
- P150 The Triptryium wilfordii derivative celastrol has anti-fibrotic effects in systemic sclerosis (2023) (0)
- Welcome to 2021 (2021) (0)
- S.6.1 β-catenin is a central mediator in SSc (2012) (0)
- Control of fibroblast extracellular matrix production by CTGF: regulation by TGF beta, TNF-alpha and IL-1 (2001) (0)
- CTGF Contributes to collagen type I expression in the bleomycin model of lung fibrosis and in human pulmonary fibroblasts by MAPK dependent transcriptional activation (2009) (0)
- The role of CCN2 in tissue remodelling: Impaired migration of CCN2-deficient mouse embryonic fibroblasts. (2005) (0)
- OP0155 A Novel Model of Systemic Sclerosis?: Loss of PTEN in Fibroblasts Results in Lung Fibrosis in A CCN2/CTGF-Dependent Fashion (2013) (0)
- CCN3: stopping that achy, breaky aorta (2017) (0)
- Investigation of the role of Racl in a bleomycin-induced scleroderma model using fibroblast-specific Racl knockout mice (2009) (0)
- Modeling the microenvironment special issue (2022) (0)
- Abstract 20118: Wnt1 Mediated Dynamic Injury Response Activates the Epicardium and is Critical for Mammalian Cardiac Repair (2010) (0)
- LOSS OF PTEN EXPRESSION IN SKIN FIBROBLASTS CONTRIBUTES TO FIBROSIS IN SCLERODERMA (2011) (0)
- CCN2 is required for recruitment of Sox2-expressing cells during cutaneous tissue repair (2014) (0)
- HIJACKING ZIPCODES : POSTTANSCRIPTIONAL REGULATION OF CCN 2 BY NUCLEOPHOSIN (2008) (0)
- TGFβ regulates collagen deposition by modulating PTEN expression and activity in trabecular meshwork cells (2016) (0)
- Connective Tissue Growth Factor (CTGF) expression in response to injury mediates matrix deposition in bleomycin-induced lung fibrosis. (2002) (0)
- RAC INHIBITION REVERSES THE PERSISTENT FIBROTIC PHENOTYPE OF SCLERODERMA DERMAL FIBROBLASTS (2010) (0)
- CCN6: a modulator of breast cancer progression (2016) (0)
- PTEN KNOCKOUT MICE: A NOVEL MODEL OF LUNG FIBROSIS IN SCLERODERMA (2012) (0)
- FAK/SRC INHIBITION ALLEVIATES THE PERSISTENT FIBROTIC PHENOTYPE OF LESIONAL SCLERODERMA FIBROBLASTS (2012) (0)
- Egr-ly awaiting a “personalized medicine” approach to treat scleroderma (2012) (0)
- PPAR-GAMMA AGONIST ROSIGLITAZONE ALLEVIATES THE FIBROTIC PHENOTYPE OF SKIN SCLERODERMA FIBROBLASTS (2009) (0)
- Transforming growth factor-β (TGF-β) and connective tissue growth factor (CCN2, CTGF) induce a mesenchymal-like phenotype in type II alveolar epithelial cells in lung fibrosis. (2011) (0)
- Post-natal fibroblast-specific deletion of the Pten gene in fibroblasts induces a scleroderma phenotype (2010) (0)
- CCN2-induced EMT in lung fibrosis (2013) (0)
- RESULTS The Ability of CCN 2 to Bind to the Cell Surface of Adult Human Dermal Fibroblasts Is (2004) (0)
- LOSS OF PTEN, VIA A CCN2-DEPENDENT MECHANISM-RESULTS IN A SCLERODERMA-LIKE PHENOTYPE IN VIVO (2012) (0)
- Endothelin regulation by miR-218: A target in scarring (2013) (0)
- 1 Tensegrity : The Importance of Mechanical Forces in Scleroderma Fibrosis (2013) (0)
- Global TNF-alpha regulated gene expression in chondrocytes (2008) (0)
- Canadian connective tissue conference London, Ontario: an editorial (2015) (0)
- Program: Novel targets for cancer and connective tissues diseases – A meeting sponsored by the International CCN Society (2011) (0)
- Sonic advance: CCN1 regulates sonic hedgehog in pancreatic cancer (2012) (0)
- TGF-BETA INDUCTION OF THE MYOFIBROBLAST PHENOTYPE REQUIRES TAK-1 (2009) (0)
- Report on the 9th international workshop on the CCN family of genes, November 2–7, 2017, Saint-Malo, France (2018) (0)
- CCN3: stopping that achy, breaky aorta (2016) (0)
- CCN2 deficiency in chondrocytes does not exacerbate osteoarthritis in trauma-induced mouse models (2018) (0)
- 241. Skin Progenitor Cells Contribute to Skin Fibrosis (2014) (0)
- ROLE OF THE RAS/MEK/ERK SIGNALING PATHWAY AND ITS INHIBITORY REGULATION BY PROSTANOIDS IN THE FIBROTIC/WOUND HEALING RESPONSE (2004) (0)
- S.10.1 FRA-2 transgenic mice display the main features of SSC-associated pulmonary hypertension in a PDGF-BB/PDGFR pathway dependent manner (2012) (0)
- CCN2 is essential for early chondrogenesis (2008) (0)
- The role of the tumor microenvironment: The matricellular protein CCN2/CTGF is essential for melanoma metastasis (2016) (0)
- Tumor-Associated Fibrosis Impairs the Response to Immunotherapy. (2023) (0)
- (5Z)-7-oxozeaenol reduces TGFβ1-induced collagen expression. (2015) (0)
- TAK1 regulates extracellular matrix remodelling by fibroblasts (2008) (0)
- GSK3b controls the intensity of tissue repair by regulating ET-1 (2008) (0)
- Upregulation of angiotensin signalling pathways underlies the increased contractility observed in pulmonary fibrosis lung fibroblasts (2010) (0)
- MEK/ERK inhibitors: proof-of-concept studies in lung fibrosis (2011) (0)
- (5Z)-7-oxozeaenol reduces TGFβ1 induced gingival fibroblast proliferation. (2015) (0)
- Report on the 6th international workshop of the CCN family of genes (2011) (0)
- Epithelial to mesenchymal switching in the pathogenesis of systemic sclerosis (2010) (0)
- CCN2: a mechanosignaling sensor modulating integrin-dependent connective tissue remodeling in fibroblasts? (2013) (0)
- CTGF is a Modifiable Mediator of Flow-dependent Atherosclerosis under Peripheral Artery Disease Conditions (2023) (0)
- Fixing a hole: CCN2 closes chronic wounds (2015) (0)
- Periostin knockout mice show a reduction in collagen production, wound contraction and TGF β1 response in experimentally induced dermal wounds (2010) (0)
- ALK5 inhibition blocks TGFβ-induced CCN1 expression in human foreskin fibroblasts (2014) (0)
- A sticky wicket: Overexpression of integrin alpha 11 is sufficient for cardiac fibrosis (2018) (0)
- p38 MAP kinase mediates CTGF expression in Huh7.5-FL cells. (2013) (0)
- INTEGRIN B1 EXPRESSION BY FIBROBLASTS IS REQUIRED FOR TISSUE REPAIR IN VIVO (2010) (0)
- 211 NOX1/NOX4 inhibition blocks the profibrotic activity of scleroderma fibroblasts (2018) (0)
- Matrix remodeling in systemic sclerosis (2015) (0)
- Why target the tumor stroma in melanoma? (2017) (0)
- Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of CCN2 (2020) (0)
- Targeting the annulus fibrosus of the intervertebral disc: Col1a2-Cre(ER)T mice show specific activity of Cre recombinase in the outer annulus fibrosus (2016) (0)
- CCN2-EXPRESSING PERICYTES ARE REQUIRED FOR BLEOMYCIN-INDUCED SKIN SCLERODERMA (2010) (0)
- THE RELEVANCE OF THE EPITHELIAL-MESENCHYMAL TRANSITION FOR SYSTEMIC SCLEROSIS (2011) (0)
- Dissecting the role of mesenchymal progenitor cells in scleroderma (2008) (0)
- What a long, strange trip it’s been (2020) (0)
- Activation of latent TGFβ by αvβ1 integrin: of potential importance in myofibroblast activation in fibrosis (2014) (0)
- Canadian connective tissue conference London, Ontario: an editorial (2015) (0)
- Fixing a hole: CCN2 closes chronic wounds (2015) (0)
- Dysregulated TGF-beta signalling in scleroderma fibroblasts and the effect of over-expression of endoglin. (2002) (0)
- 284-OR: Hepatocyte-Specific CCN2 Gene Deletion Prevents NASH Fibrosis in a Mouse Model of High-Fat Feeding and Diabetes (2021) (0)
- Is the paradoxical increase of cartilage thickness in ctgf null mice due to compensation by activin A (2020) (0)
- Blisters on your fingers (2021) (0)
- Thrombospondin-1 mediates the biomechanical response of fibroblasts within contracted collagen matrices (2007) (0)
- What a long, strange trip it’s been (2020) (0)
- Expression of matricellular protein CCN1 in the tumor stroma is required for melanoma metastasis (2017) (0)
- Mechanism underlying the overexpression of CTGF in scleroderma fibroblasts: Role in elevated expression in scleroderma phenotype. (2003) (0)
- CCN3: a novel anti-fibrotic treatment in end-stage renal disease? (2012) (0)
- Scleroderma and Related Disorders [202–212] 202. Multi-Centre Audit of Treatment of Interstitial Lung Disease in Systemic Sclerosis with iv Cyclophosphamide (2010) (0)
- Yin and Yang revisited: CCN3 as an anti-fibrotic therapeutic? (2015) (0)
- Endothelin-1 expression is a downstream mediator of TGF-beta signalling in normal and scleroderma lung fibroblasts: Insights into the molecular basis of pulmonary fibrosis. (2005) (0)
- Keratocyte-Extracellular Matrix Adhesion Regulates Structural Integrity of Cornea (2010) (0)
- Abstract A18: Ccn1 expression by fibroblasts is required for melanoma metastasis (2020) (0)
- TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma (2017) (0)
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What Schools Are Affiliated With Andrew Leask?
Andrew Leask is affiliated with the following schools:
