Andrew Wyllie

Q: What Schools Are Affiliated With Andrew Wyllie

Andrew Wyllie is affiliated with the following schools: Institute of Cancer Research, University of Edinburgh, University of Aberdeen, University of Cambridge

Andrew Wyllie 's AcademicInfluence.com Rankings

Andrew Wyllie

Biology

#2124

World Rank

#3412

Historical Rank

Pathology

#24

World Rank

#59

Historical Rank

biology Degrees

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Biology

Why Is Andrew Wyllie Influential?

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According to Wikipedia, Andrew David Hamilton Wyllie FMedSci FRS was a Scottish pathologist. In 1972, while working with electron microscopes at the University of Aberdeen he realised the significance of natural cell death. He and his colleagues John Kerr and Alastair Currie called this process apoptosis, from the use of this word in an ancient Greek poem to mean "falling off" . He completed postdoctoral training in Cambridge University and became Professor of Experimental Pathology at the University of Edinburgh Medical School in 1992. He left Edinburgh for a chair at Cambridge in 1998 where he continued to lecture to undergraduate medical and natural sciences students. His works have contributed to the understanding of apoptosis in health and in disease. Apoptosis is used during early development to eliminate unwanted cells; for example, those between the fingers of a developing hand. In adults, apoptosis is used to rid the body of cells that have been damaged beyond repair. Apoptosis also plays a critical role in preventing cancer. If apoptosis is for some reason prevented, it can lead to uncontrolled cell division and the subsequent development of a tumour.

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Andrew Wyllie 's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics (1972) (15712)
Cell death: the significance of apoptosis. (1980) (7584)
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation (1980) (4704)
Induction of apoptosis in fibroblasts by c-myc protein (1992) (3152)
Thymocyte apoptosis induced by p53-dependent and independent pathways (1993) (2433)
Apoptosis. The role of the endonuclease. (1990) (1735)
Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. (1989) (1662)
Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis (1984) (1603)
Apoptosis: mechanisms and roles in pathology. (1991) (1393)
Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients (1996) (975)
Defying death after DNA damage (2000) (788)
Cancer risk associated with germline DNA mismatch repair gene mutations. (1997) (702)
Death and the cell. (1986) (686)
Cell death: a new classification separating apoptosis from necrosis (1981) (625)
Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. (1992) (585)
Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration. (1989) (559)
Macrophage recognition of cells undergoing programmed cell death (apoptosis). (1985) (489)
Apoptosis (the 1992 Frank Rose Memorial Lecture). (1993) (449)
Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. (1993) (447)
Apoptosis: an overview. (1997) (375)
Genetic instability occurs in the majority of young patients with colorectal cancer (1995) (372)
APC mutations in colorectal tumors with mismatch repair deficiency. (1996) (364)
Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. (1994) (343)
p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. (1994) (290)
The genetic regulation of apoptosis. (1995) (289)
The biology of cell death in tumours. (1985) (274)
Hormone-induced cell death. Purification ad properties of thymocytes undergoing apoptosis after glucocorticoid treatment. (1982) (267)
Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview (1992) (261)
p53 expression in colorectal tumors. (1991) (261)
Cell death in health and disease: the biology and regulation of apoptosis. (1995) (253)
Microsatellite instability and the role of hMSH2 in sporadic colorectalcancer. (1996) (250)
Hormone-induced cell death. 2. Surface changes in thymocytes undergoing apoptosis. (1984) (215)
PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice (2010) (205)
Papillomaviruses and human cancer. (1990) (196)
Rodent fibroblast tumours expressing human myc and ras genes: growth, metastasis and endogenous oncogene expression. (1987) (193)
Accuracy of reporting of family history of colorectal cancer (2004) (190)
“Where, O Death, Is Thy Sting?” A Brief Review of Apoptosis Biology (2010) (178)
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement (2001) (177)
Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress. (1988) (170)
Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine. (1999) (167)
Expression of the human mismatch repair gene hMSH2 in normal and neoplastic tissues. (1996) (166)
Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras, and HPV oncogenes. (1994) (156)
Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency (1999) (143)
Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression (2010) (136)
More than one way to go. (2001) (126)
Apoptosis: an overview of the process and its relevance in disease. (1997) (125)
Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability. (1993) (124)
Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence for chromosomal or microsatellite instability (1999) (122)
High frequency of APC loss in sporadic colorectal carcinoma due to breaks clustered in 5q21-22. (1989) (121)
DNA chip technolgy (1999) (116)
Stabilised p53 facilitates aneuploid clonal divergence in colorectal cancer. (1993) (116)
Selective DNA conservation and chromatin assembly after injection of SV40 DNA into Xenopus oocytes. (1978) (115)
APC EXPRESSION IN NORMAL HUMAN TISSUES (1997) (114)
The apoptosis endonuclease and its regulation. (1992) (109)
NF-κB Inhibits Apoptosis in Murine Mammary Epithelia* (2000) (107)
Apoptosis: cell death under homeostatic control. (1987) (102)
Chromatin changes in apoptosis (1981) (102)
Apoptosis: the germs of death (1999) (100)
Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer. (1993) (99)
Microsomal epoxide hydrolase gene polymorphism and susceptibility to colon cancer (1999) (98)
THE PATTERN OF K‐rasMUTATION IN PULMONARY ADENOCARCINOMA DEFINES A NEW PATHWAY OF TUMOUR DEVELOPMENT IN THE HUMAN LUNG (1997) (96)
Absence of p53 permits propagation of mutant cells following genotoxic damage (1997) (92)
Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers (2002) (84)
A polymorphism in the CYP17 gene is associated with male breast cancer (1999) (84)
p53 deficiency in liver reduces local control of survival and proliferation, but does not affect apoptosis after DNA damage (1997) (84)
A study of stabilisation of p53 protein versus point mutation in colorectal carcinoma. (1994) (82)
P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells (1999) (82)
p53-dependent apoptosis induced by proteasome inhibition in mammary epithelial cells (2001) (79)
Immunohistochemical detection of the ras oncogene p21 product in an experimental tumour and in human colorectal neoplasms. (1985) (78)
Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes (2001) (77)
Induction of apoptosis in NIH3T3 cells after serum deprivation by overexpression of rho-p21, a GTPase protein of the ras superfamily. (1995) (76)
Death from inside out: an overview. (1994) (75)
Deletion mapping in colorectal cancer of a putative tumour suppressor gene in 8p22-p21.3. (1993) (74)
MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer. (1991) (71)
N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions (1997) (70)
HPV in full thickness cervical biopsies: High prevalence in CIN 2 and CIN 3 detected by a sensitive PCR method (1991) (69)
Apoptosis: Clues in the p53 murder mystery (1997) (67)
ras p21 expression in the progression of breast cancer. (1988) (67)
Dysregulated expression of β-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice (1999) (66)
Apoptosis and carcinogenesis. (1999) (66)
APC mutation analysis by chemical cleavage of mismatch and a protein truncation assay in familial adenomatous polyposis. (1994) (59)
Linked DNA markers for presymptomatic diagnosis of familial adenomatous polyposis (1991) (56)
Prognostic relevance of DNA copy number changes in colorectal cancer (2010) (55)
MMASS: an optimized array-based method for assessing CpG island methylation (2006) (53)
Chromatin assembly and transcription in eggs and oocytes of Xenopus laevis. (1978) (51)
Evidence for an age‐related influence of microsatellite instability on colorectal cancer survival (2002) (51)
LOSS OF HETEROZYGOSITY AT 5q21 IN NON‐SMALL CELL LUNG CANCER: A FREQUENT EVENT BUT WITHOUT EVIDENCE OF APC MUTATION (1996) (51)
Chromosomal instability and p53 inactivation are required for genesis of glioblastoma but not for colorectal cancer in patients with germline mismatch repair gene mutation (2000) (50)
p53‐independent DNA repair and cell cycle arrest in embryonic stem cells (1998) (49)
Human papillomavirus type 18 associates with more advanced cervical neoplasia than human papillomavirus type 16. (1993) (47)
NF-kappaB inhibits apoptosis in murine mammary epithelia. (2000) (47)
Detailed physical and deletion mapping of 8p with isolation of YAC clones from tumour suppressor loci involved in colorectal cancer. (1996) (45)
p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs. (1995) (44)
Lymphocyte Apoptosis ‐ Mechanisms and Implications in Disease (1994) (43)
The CAG repeat within the androgen receptor gene in male breast cancer patients (2000) (43)
Mutation of the p53 gene precedes aneuploid clonal divergence in colorectal carcinoma. (1995) (42)
Ki‐ras MUTATIONS IN ADENOMAS: A CHARACTERISTIC OF CANCER‐BEARING COLORECTAL MUCOSA (1996) (41)
Role of BAX mutations in mismatch repair-deficient colorectal carcinogenesis (1999) (40)
Germline APC mutation (Gln1317) in a cancer‐prone family that does not result in familial adenomatous polyposis (1996) (36)
Specific patterns of chromosomal abnormalities are associated with RER status in sporadic colorectal cancer (2000) (33)
Immunohistochemical demonstration of altered intracellular localization of the c‐Myc oncogene product in human colorectal neoplasms (1990) (33)
Identification of a region of frequent loss of heterozygosity at 11q24 in colorectal cancer. (1999) (32)
Evaluation of a monoclonal antibody to ras peptide, RAP-5, claimed to bind preferentially to cells of infiltrating carcinomas. (1986) (31)
Caspase‐mediated cleavage of APC results in an amino‐terminal fragment with an intact armadillo repeat domain (1999) (30)
Ras p21 in breast tissue: associations with pathology and cellular localisation. (1992) (30)
Death in normal and neoplastic cells (1974) (30)
Genetic linkage map of six polymorphic DNA markers around the gene for familial adenomatous polyposis on chromosome 5. (1990) (29)
UV but not γ‐irradiation induces specific transcriptional activity of p53 in primary hepatocytes (1997) (29)
Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background (2002) (28)
Stability of critical genetic lesions in human colorectal carcinoma xenografts. (1991) (28)
p53 is not required for regulation of apoptosis or radioprotection by interleukin-3. (1997) (28)
Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer. (1994) (28)
The Edinburgh intercalated honours BSc in pathology: evaluation of selection methods, undergraduate performance, and postgraduate career. (1986) (25)
E2F1 selects tumour cells for both life and death (2002) (24)
Retroviral vectors (2000) (23)
The uptake and stability of simian-virus-40 DNA after calcium phosphate transfection of CV-1 cells. (1984) (23)
N-acetyl transferase 1: two polymorphisms in coding sequence identified in colorectal cancer patients. (1998) (23)
Linkage analysis in familial adenomatous polyposis: order of C11P11 (D5S71) and pi 227 (D5S37) loci at the apc gene. (1989) (22)
Deletion analysis of chromosome 8p in sporadic colorectal adenomas. (1994) (21)
UV but not gamma-irradiation induces specific transcriptional activity of p53 in primary hepatocytes. (1997) (21)
Apoptosis in carcinogenesis: the role of p53. (1994) (21)
Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16. (1995) (20)
The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy (1995) (18)
Stress responses of PML nuclear domains are ablated by ataxin‐1 and other nucleoprotein inclusions (2004) (18)
Relative expression of wild-type and activated ki-ras2 oncogene in colorectal carcinomas. (1993) (17)
SspI polymorphism in sequence encoding 3' untranslated region of the APC gene. (1991) (16)
Enhancement of DNA-mediated gene transfer by high-Mr carrier DNA in synchronized CV-1 cells. (1985) (15)
Apoptosis. Death gets a brake. (1994) (15)
Death from inside out: the role of apoptosis in development, tissue homeostasis and malignancy - Preface (1994) (14)
Extracolonic features of familial adenomatous polyposis in patients with sporadic colorectal cancer. (1996) (14)
The mode of cell death associated with cavitation in teratocarcinoma-derived embryoid bodies. (1984) (13)
17q allele loss is associated with lymph node metastasis in locally aggressive human colorectal cancer (1995) (13)
High tyrosinase activity in albino Xenopus laevis oocytes. (1976) (12)
No female embryonic lethality in mice nullizygous for Msh2 and p53 (1998) (12)
The roles of p53 in apoptosis and cancer (1997) (12)
Cellular events in the adrenal cortex following ACTH deprivation. (1972) (11)
MaeIII polymorphism in sequence encoding 3' untranslated region of the MCC gene. (1992) (11)
Proliferation and death of conditionally immortalized neural cells from murine neocortex: p53 alters the ability of neuron-like cells to re-enter the cell cycle (2003) (11)
Nuclease Activation in Programmed Cell Death (1986) (10)
Nuclear phospholipase C gamma: punctate distribution and association with the promyelocytic leukemia protein. (2007) (10)
The role of oncogene products in neutrophil apoptosis. (1994) (8)
The transcription and translation of DNA injected into oocytes. (1978) (7)
Detection of mutations associated with colorectal cancer in DNA from whole-gut lavage fluid. (1998) (7)
T Cell Death and Transforming Growth Factor β1 (2001) (7)
Optimal preservation of p21 ras immunoreactivity and morphology in paraffin‐embedded tissue (1988) (6)
Status of the APC Gene in Familial and Sporadic Colorectal Tumours as Determined by Closely Flanking Markers (1990) (6)
What is apoptosis? (1986) (5)
Exclusion of constitutional p53 mutations as a cause of genetic susceptibility to colorectal cancer. (1993) (5)
Lymphocyte death, p53, and the problem of the "undead" cell. (1995) (5)
A polymorphic tetranucleotide repeat in the CYP19 gene and male breast cancer (2000) (4)
Ki-ras mutations in stool and whole-gut lavage fluid. (1997) (3)
Single strand DNA breaks in mitogen stimulated T lymphocytes are religated by a mechanism independent of accessory cells. (1989) (3)
Apoptosis in the rat adrenal cortex (1975) (3)
Regulation of apoptosis in tumours by omcogenes (1990) (2)
Apoptosis and carcinogenesis. (1997) (2)
The role of the foetal pituitary in the susceptibility of the foetus to adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)anthracene. (1971) (1)
Detection of human Ha-ras transcripts in tumor cells by in situ hybridization. (1989) (1)
DNA Degradation - double-strand breaks. (1994) (1)
Familial adenomatous polyposis coli in South Africa--molecular basis and diagnosis. (2000) (1)
Commentary (1986) (1)
Apoptosis in health and disease (2010) (0)
Abstract 94: Wnt signaling antagonists are progressively hypermethylated during colorectal neoplastic progression (2011) (0)
The Oxford Textbook of Medicine (2010) (0)
Repair Gene Mutations in Young Chinese Patients With Colorectal Cancer (1999) (0)
1Mb resolution array-CGH identifies small chromosome aberrations in chromosome unstable and microsatellite unstable colorectal cancers [Abstract] (2005) (0)
NUCLEAR TRANSPLANTATION AND GENE INJECTION IN THE ANALYSIS OF AMPHIBIAN DEVELOPMENT (1978) (0)
Adenomatous Polyposis Coli (2001) (0)
Rapid Communication p53 Expression in Colorectal Tumors (2007) (0)
Cyclin D2 gene abnormalities in colorectal cancers identified by array comparative genomic hybridisation (2006) (0)
Thymocytes Undergoing Apoptosis (2007) (0)
1Mb resolution array-CGH identifies small chromosome aberrations in colorectal cancers [Abstract] (2005) (0)
Regulation of Cell Death by ras and myc Oncogenes (1989) (0)
GLUCOCORTICOID-INDUCED THYMOCYTE DEATH: NUCLEAR CHANGES OBSERVED IN PURIFIED APOPTOTIC CELL POPULATIONS (1981) (0)
Apoptosis IsInversely Related toNecrosis and Determines NetGrowthinTumorsBearing Constitutively Expressed myc,ras, andHPV Oncogenes (1994) (0)
Cell deletion in differentiation. (1982) (0)
Simian-virus-40 DNA transfection of synchronized CV-1 cells (1984) (0)
Death in normal and neoplastic cells (1974) (0)
4.6 Apoptosis in health and disease (2010) (0)
P1-008 Defective immune homeostasis mechanisms in Celiac Disease (CD), in its progression to Refractory Celiac Disease (RCD) and transformation to Enteropathy-Associated T-Cell Lymphoma (EATL type 1). (2012) (0)
p53 is not required for regulation of apoptosis or radioprotection by IL-3 (1997) (0)
Array-CGH demonstrates chromosome aberrations in both near-diploid and microsatellite unstable colorectal cancers [Abstract] (2004) (0)
Spectral Karyotyping reveals a new subset of colorectal cancers characterized by balanced translocations (2001) (0)
Studies on the endocrine control of the rat foetal thymus. (1971) (0)
DNA chip technology. (1999) (0)
Growth of in vitro cultured Landschütz ascites tumour in normal and resistant mice. (1967) (0)

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What Schools Are Affiliated With Andrew Wyllie ?

Andrew Wyllie is affiliated with the following schools: