Angela Casini
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Medicinal and inorganic chemist
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Angela Casinichemistry Degrees
Chemistry
#2418
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#3324
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Inorganic Chemistry
#129
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#141
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Organic Chemistry
#673
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#768
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Chemistry
Angela Casini's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry University of Oxford
Why Is Angela Casini Influential?
(Suggest an Edit or Addition)According to Wikipedia, Angela Casini is a medicinal and inorganic chemist who works on metal-based compounds as therapeutic agents. She was awarded the 2012 European Medal for Bio-Inorganic Chemistry and made the 2019 American Chemical Society Inorganic Lecturer.
Angela Casini's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Carbonic anhydrase inhibitors. (2001) (1016)
- Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH (2004) (646)
- Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs (2009) (453)
- Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition. (2004) (404)
- Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies (2010) (374)
- Carbonic anhydrase inhibitors (2003) (365)
- Protease inhibitors of the sulfonamide type: Anticancer, antiinflammatory, and antiviral agents (2003) (336)
- Organometallic ruthenium-based antitumor compounds with novel modes of action (2011) (315)
- A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds. (2014) (311)
- Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. (2004) (248)
- Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds. (2008) (246)
- Sulfonamides and sulfonylated derivatives as anticancer agents. (2002) (233)
- Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of action. (2008) (226)
- Connecting copper and cancer: from transition metal signalling to metalloplasia (2021) (225)
- Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family* (2004) (224)
- Organometallic ruthenium(II) arene compounds with antiangiogenic activity. (2011) (221)
- Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV. (2003) (200)
- Gold(I) carbene complexes causing thioredoxin 1 and thioredoxin 2 oxidation as potential anticancer agents. (2012) (194)
- Next-generation anticancer metallodrugs. (2012) (176)
- Self-assembled M2L4 coordination cages: Synthesis and potential applications (2014) (167)
- Structural and solution chemistry, antiproliferative effects, and DNA and protein binding properties of a series of dinuclear gold(III) compounds with bipyridyl ligands. (2006) (165)
- Caffeine-based gold(I) N-heterocyclic carbenes as possible anticancer agents: synthesis and biological properties. (2014) (164)
- Designing of Novel Carbonic Anhydrase Inhibitors and Activators. (2004) (162)
- Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. (2005) (160)
- Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry? (2012) (158)
- Molecular mechanisms and proposed targets for selected anticancer gold compounds. (2011) (153)
- COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents. (2004) (151)
- New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications (2008) (147)
- ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme. (2007) (141)
- Cellular Transport Mechanisms of Cytotoxic Metallodrugs: An Overview beyond Cisplatin (2014) (139)
- Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase. (2004) (136)
- Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX. (2004) (135)
- Mechanisms of cell injury in the killing of cultured hepatocytes by bromobenzene. (1982) (130)
- Metal-based inhibition of poly(ADP-ribose) polymerase--the guardian angel of DNA. (2011) (122)
- Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: a systematic study (2009) (121)
- Emerging protein targets for metal-based pharmaceutical agents: an update (2013) (120)
- Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. (2000) (119)
- The Promise of Self-Assembled 3D Supramolecular Coordination Complexes for Biomedical Applications. (2017) (117)
- Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors. (2003) (116)
- Targeting Aquaporin Function: Potent Inhibition of Aquaglyceroporin-3 by a Gold-Based Compound (2012) (115)
- Gold(III) compounds as anticancer drugs (2007) (115)
- Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs. (2013) (115)
- Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N -chelating ligand (2010) (109)
- Dependence of the carbon-tetrachloride--induced death of cultured hepatocytes on the extracellular calcium concentration. (1981) (109)
- Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands (2010) (107)
- Development of Sulfonamide Carbonic Anhydrase Inhibitors (2004) (107)
- Fluorescent silver(I) and gold(I)-N-heterocyclic carbene complexes with cytotoxic properties: mechanistic insights. (2013) (106)
- Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease. (2009) (103)
- DNA as a possible target for antitumor ruthenium(III) complexes. (2000) (101)
- Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin. (2016) (98)
- Structural investigation of cisplatin-protein interactions: selective platination of His19 in a cuprozinc superoxide dismutase. (2006) (96)
- Structural characterization, solution studies, and DFT calculations on a series of binuclear gold(III) oxo complexes: relationships to biological properties. (2008) (95)
- Reactivity of anticancer metallodrugs with serum proteins: new insights from size exclusion chromatography-ICP-MS and ESI-MS. (2010) (95)
- Formation of Supramolecular Structures between DNA and Starburst Dendrimers Studied by EPR, CD, UV, and Melting Profiles (2000) (93)
- Oxygen-mediated cell injury in the killing of cultured hepatocytes by acetaminophen. (1985) (93)
- Exploring metallodrug–protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound (2009) (91)
- Antiproliferative Activity of Gold(I) Alkyne Complexes Containing Water-Soluble Phosphane Ligands (2010) (91)
- Recent Developments of Supramolecular Metal-based Structures for Applications in Cancer Therapy and Imaging (2019) (86)
- Exploring Metallodrug–Protein Interactions by ESI Mass Spectrometry: The Reaction of Anticancer Platinum Drugs with Horse Heart Cytochrome c (2006) (83)
- Mass spectrometry as a powerful tool to study therapeutic metallodrugs speciation mechanisms: Current frontiers and perspectives (2017) (82)
- Thioredoxin reductase, an emerging target for anticancer metallodrugs (2011) (79)
- Antimalarial properties of green tea. (2007) (78)
- Potential pathogenic role of β-amyloid1–42–aluminum complex in Alzheimer's disease ☆ (2008) (78)
- Mass spectrometric analysis of ubiquitin–platinum interactions of leading anticancer drugs: MALDI versus ESI (2007) (78)
- Development of bimetallic titanocene-ruthenium-arene complexes as anticancer agents: relationships between structural and biological properties. (2010) (77)
- ESI–MS Characterisation of Protein Adducts of Anticancer Ruthenium(II)‐Arene PTA (RAPTA) Complexes (2007) (77)
- Gold(I) NHC-based homo- and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents (2015) (76)
- Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides. (2004) (75)
- Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation. (2016) (75)
- Potential anticancer heterometallic Fe-Au and Fe-Pd agents: initial mechanistic insights. (2013) (74)
- New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators. (2004) (74)
- Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of amyloid-beta1-42: an AFM study. (2010) (73)
- Synthesis, characterisation and biological properties of gold(III) compounds with modified bipyridine and bipyridylamine ligands. (2010) (73)
- Aquaporin Inhibition by Gold(III) Compounds: New Insights (2013) (72)
- Multinuclear cytotoxic metallodrugs: physicochemical characterization and biological properties of novel heteronuclear gold-titanium complexes. (2011) (72)
- Rationalization of the inhibition activity of structurally related organometallic compounds against the drug target cathepsin B by DFT. (2010) (71)
- [Au2(phen(2Me))2(μ-O)2](PF6)2, a Novel Dinuclear Gold(III) Complex Showing Excellent Antiproliferative Properties. (2010) (70)
- Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives. (2003) (69)
- Biophysical characterisation of adducts formed between anticancer metallodrugs and selected proteins: new insights from X-ray diffraction and mass spectrometry studies. (2008) (66)
- The reaction of artemisinins with hemoglobin: a unified picture. (2006) (64)
- Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N-Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group. (2015) (63)
- Cytotoxic Gold(I) N‐heterocyclic Carbene Complexes with Phosphane Ligands as Potent Enzyme Inhibitors (2014) (62)
- Organometallic Antitumour Agents with Alternative Modes of Action (2010) (62)
- New Gold(I) Organometallic Compounds with Biological Activity in Cancer Cells (2014) (62)
- Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates. (2003) (62)
- Functional Inhibition of Aquaporin‐3 With a Gold‐Based Compound Induces Blockage of Cell Proliferation (2014) (60)
- Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride. (2004) (59)
- Improved synthesis of N-benzylaminoferrocene-based prodrugs and evaluation of their toxicity and antileukemic activity. (2015) (59)
- Cytotoxic gold compounds: synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1. (2012) (58)
- Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions. (2000) (58)
- Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits. (2004) (58)
- New Luminescent Polynuclear Metal Complexes with Anticancer Properties: Toward Structure-Activity Relationships. (2016) (57)
- Characterization of Hydrophilic Gold(I) N-Heterocyclic Carbene (NHC) Complexes as Potent TrxR Inhibitors Using Biochemical and Mass Spectrometric Approaches. (2017) (57)
- Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties. (2005) (57)
- Thiolato gold(I) complexes containing water-soluble phosphane ligands: a characterization of their chemical and biological properties. (2011) (55)
- Reactivity of an antimetastatic organometallic ruthenium compound with metallothionein-2: relevance to the mechanism of action. (2009) (54)
- New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: are two metals better than one? (2014) (53)
- Aquaporin modulators: a patent review (2010–2015) (2017) (52)
- Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles. (2009) (52)
- Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: relevance to antitumour activity. (2008) (52)
- Ferrocenyl-Coupled N-Heterocyclic Carbene Complexes of Gold(I): A Successful Approach to Multinuclear Anticancer Drugs. (2016) (52)
- Conjugation of Organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and Indolo[3,2-d]benzazepines to Recombinant Human Serum Albumin: a Strategy To Enhance Cytotoxicity in Cancer Cells (2011) (50)
- Exploring the potential of gold(III) cyclometallated compounds as cytotoxic agents: variations on the C^N theme. (2015) (50)
- Targeting cysteine residues of biomolecules: new approaches for the design of antiviral and anticancer drugs. (2002) (50)
- Sulfonamide derivatives with protease inhibitory action as anticancer, anti-inflammatory and antiviral agents (2002) (49)
- Unravelling the chemical nature of copper cuprizone. (2007) (48)
- Interactions of two cytotoxic organotin(IV) compounds with calf thymus DNA. (2001) (48)
- BODIPY-phosphane as a versatile tool for easy access to new metal-based theranostics. (2013) (47)
- Exploring the mechanisms of metal-based pharmacological agents via an integrated approach. (2012) (47)
- Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties. (2001) (47)
- Exploiting soft and hard X-ray absorption spectroscopy to characterize metallodrug/protein interactions: the binding of [trans-RuCl4(Im)(dimethylsulfoxide)][ImH] (Im = imidazole) to bovine serum albumin. (2008) (47)
- Aquaporins in cancer development: opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents. (2018) (46)
- Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: first report of relevant thioredoxin reductase inhibition for a ruthenium compound. (2007) (46)
- Metallo-drugs: development and action of anticancer agents (2018) (45)
- On the Mechanism of Gold/NHC Compounds Binding to DNA G-Quadruplexes: Combined Metadynamics and Biophysical Methods. (2018) (44)
- A Gold Coordination Compound as a Chemical Probe to Unravel Aquaporin‐7 Function (2014) (44)
- Ruthenium anticancer drugs and proteins: a study of the interactions of the ruthenium(III) complex imidazolium trans-[tetrachloro(dimethyl sulfoxide)(imidazole)ruthenate(III)] with hen egg white lysozyme and horse heart cytochrome c (2007) (44)
- Carbonic Anhydrase Inhibitors: X-ray Crystallographic Structure of the Adduct of Human Isozyme II with the Perfluorobenzoyl Analogue of Methazolamide. Implications for the Drug Design of Fluorinated Inhibitors (2003) (44)
- Cyclometalated Complexes of Platinum and Gold with Biological Properties: State-of-the-Art and Future Perspectives. (2017) (43)
- Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design. (2004) (42)
- Mass Spectrometry Uncovers Molecular Reactivities of Coordination and Organometallic Gold(III) Drug Candidates in Competitive Experiments That Correlate with Their Biological Effects. (2016) (42)
- Insights into the molecular mechanisms of protein platination from a case study: the reaction of anticancer platinum(II) iminoethers with horse heart cytochrome c. (2007) (42)
- Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells. (2016) (41)
- Cysteine-modifying agents: a possible approach for effective anticancer and antiviral drugs. (2002) (41)
- On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging. (2017) (41)
- Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamide. (2004) (40)
- Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library. (2004) (39)
- Medicinal Chemistry of Gold Anticancer Metallodrugs. (2018) (38)
- Self‐Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity (2016) (37)
- The X‐ray Structure of the Adduct between NAMI‐A and Carbonic Anhydrase Provides Insights into the Reactivity of this Metallodrug with Proteins (2010) (37)
- Carbonic Anhydrase Inhibitors: Synthesis of Water Soluble Sulfonamides Incorporating a 4-sulfamoylphenylmethylthiourea Scaffold, with Potent Intraocular Pressure Lowering Properties (2002) (36)
- Potential pathogenic role of beta-amyloid(1-42)-aluminum complex in Alzheimer's disease. (2008) (36)
- The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics. (2013) (36)
- The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods. (2017) (36)
- Aquaporins in Health and Disease (2016) (35)
- Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. (2004) (35)
- Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II. (2005) (35)
- A new target for gold(I) compounds: glutathione-S-transferase inhibition by auranofin. (2013) (35)
- fac-{Ru(CO)3}2+-core complexes and design of metal-based drugs. synthesis, structure, and reactivity of Ru-thiazole derivative with serum proteins and absorption-release studies with acryloyl and silica hydrogels as carriers in physiological media. (2007) (35)
- Synthesis, molecular structure and solution chemistry of the iridium(III) complex imidazolium [trans(bisimidazole)tetrachloro iridate(III)] (IRIM) (2001) (34)
- Anticancer Gold N‐Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study (2017) (34)
- Self-assembly of highly luminescent heteronuclear coordination cages. (2016) (33)
- Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models. (2019) (33)
- Cyclometalated AuIII Complexes for Cysteine Arylation in Zinc Finger Protein Domains: towards Controlled Reductive Elimination (2019) (33)
- Reactivity and biological properties of a series of cytotoxic PtI2(amine)2 complexes, either cis or trans configured. (2012) (33)
- Gold finger formation studied by high-resolution mass spectrometry and in silico methods. (2015) (32)
- DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniques. (2007) (32)
- Gold(I) N-heterocyclic carbene complexes with an "activable" ester moiety: possible biological applications (2015) (32)
- Peculiar mechanistic and structural features of the carboplatin–cytochrome c system revealed by ESI-MS analysis (2008) (31)
- Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide. (2003) (31)
- Supramolecular exo-functionalized palladium cages: fluorescent properties and biological activity. (2016) (31)
- Gold compounds as aquaporin inhibitors: new opportunities for therapy and imaging (2014) (30)
- Luminescent iminophosphorane gold, palladium and platinum complexes as potential anticancer agents. (2014) (30)
- Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials. (2009) (29)
- Structure, solution chemistry, antiproliferative actions and protein binding properties of non-conventional platinum(II) compounds with sulfur and phosphorus donors. (2011) (29)
- The inhibition of glycerol permeation through aquaglyceroporin-3 induced by mercury(II): A molecular dynamics study. (2016) (29)
- Molecular Basis of Aquaporin-7 Permeability Regulation by pH (2018) (28)
- Imaging of protein distribution in tissues using mass spectrometry: An interdisciplinary challenge (2019) (28)
- Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide-two heads are better than one? (2003) (28)
- Bioconjugation of Supramolecular Metallacages to Integrin Ligands for Targeted Delivery of Cisplatin. (2018) (28)
- Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex. (2010) (28)
- Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver. (2020) (27)
- Selective targeting of PARP-1 zinc finger recognition domains with Au(iii) organometallics. (2018) (27)
- Reactivity of Cys4 zinc finger domains with gold(III) complexes: insights into the formation of "gold fingers". (2015) (27)
- X-ray absorption spectroscopy studies of the adducts formed between cytotoxic gold compounds and two major serum proteins (2011) (26)
- A Multi-Level Theoretical Study to Disclose the Binding Mechanisms of Gold(III)-Bipyridyl Compounds as Selective Aquaglyceroporin Inhibitors. (2017) (25)
- Insights into the Mechanisms of Aquaporin-3 Inhibition by Gold(III) Complexes: the Importance of Non-Coordinative Adduct Formation. (2019) (25)
- Mechanistic studies on two dinuclear organogold(III) compounds showing appreciable antiproliferative properties and a high redox stability. (2011) (25)
- Mechanistic Insights into Gold Organometallic Compounds and their Biomedical Applications. (2017) (24)
- Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of isozymes I and II. (2003) (24)
- Design Strategies and Medicinal Applications of Metal-Peptidic Bioconjugates. (2020) (23)
- Host–Guest Interactions in a Metal–Organic Framework Isoreticular Series for Molecular Photocatalytic CO2 Reduction (2021) (23)
- Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors? (2016) (23)
- Anticancer Gold(III) Peptidomimetics: From Synthesis to in vitro and ex vivo Biological Evaluations (2018) (23)
- Proteins as Possible Targets for Cytotoxic trans‐Platinum(II) Complexes with Aliphatic Amine Ligands: Further Exceptions to the DNA Paradigm (2010) (23)
- New copper(II)/cyclic tetrapeptide system that easily oxidizes to copper(III) under atmospheric oxygen. (2007) (23)
- Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes featuring N-heterocyclic carbene and alkynyl ligands. (2019) (23)
- New Variations on the Theme of Gold(III) C∧N∧N Cyclometalated Complexes as Anticancer Agents: Synthesis and Biological Characterization. (2018) (23)
- Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications. (2017) (22)
- The Interaction of Metal Compounds with Protein Targets: New Tools in Medicinal Chemistry and Chemical Biology (2017) (22)
- Inhibition Mechanism of Urease by Au(III) Compounds Unveiled by X-ray Diffraction Analysis. (2019) (22)
- Exploring the C^N^C theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes. (2017) (22)
- Re(VII) and Tc(VII) trioxo complexes stabilized by tridentate ligands and their potential use as radiopharmaceuticals (2014) (21)
- Structure and biological activities of metal complexes of flumequine (2016) (21)
- Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. (2005) (20)
- Light-stable bis(norharmane)silver(I) compounds: synthesis, characterization and antiproliferative effects in cancer cells. (2014) (20)
- On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent. (2017) (20)
- Transition-metal norharmane compounds as possible cytotoxic agents: New insights based on a coordination chemistry perspective. (2016) (19)
- Cyclodextrin complexes of sulfonamide carbonic anhydrase inhibitors as long-lasting topically acting antiglaucoma agents. (2002) (19)
- Functionalization of Ruthenium(II) Terpyridine Complexes with Cyclic RGD Peptides To Target Integrin Receptors in Cancer Cells (2017) (18)
- Gold compounds for catalysis and metal-mediated transformations in biological systems. (2020) (18)
- Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides (2005) (18)
- An Organometallic Gold(I) Bis‐N‐Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells (2020) (18)
- Relevance of Copper and Organic Cation Transporters in the Activity and Transport Mechanisms of an Anticancer Cyclometallated Gold(III) Compound in Comparison to Cisplatin (2018) (17)
- Interfering with Metabolic Profile of Triple-Negative Breast Cancer using Rationally-Designed Metformin Prodrugs. (2021) (17)
- Solution behaviour and biomolecular interactions of two cytotoxic trans-platinum(II) complexes bearing aliphatic amine ligands. (2009) (17)
- Aquaporin-3 is involved in NLRP3-inflammasome activation contributing to the setting of inflammatory response (2020) (16)
- Therapeutic potential of a copper complex loaded in pH-sensitive long circulating liposomes for colon cancer management. (2021) (16)
- The formation of oxytocin dimers is suppressed by the zinc-aspartate-oxytocin complex. (2013) (16)
- Comparing the Antileishmanial Activity of Gold(I) and Gold(III) Compounds in L. amazonensis and L. braziliensis in Vitro (2020) (15)
- Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes (2013) (15)
- Carbon–Phosphorus Coupling from C^N Cyclometalated AuIII Complexes (2020) (15)
- Exploring the Reactivity and Biological Effects of Heteroleptic N‐Heterocyclic Carbene Gold(I)‐Alkynyl Complexes (2020) (15)
- Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: Synthesis, DNA interactions and in vitro properties (2011) (15)
- Carbonic Anhydrase Inhibitors With Strong Topical Antiglaucoma Properties Incorporating a 4-(2-amino-pyrimidin-4-yl-amino)-benzenesulfonamide Scaffold (2002) (15)
- Correlation between the Stereochemistry and Bioactivity in Octahedral Rhodium Prolinato Complexes. (2015) (14)
- A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages (2017) (14)
- Effects of two representative antitumor ruthenium(III) complexes on thermal denaturation profiles of DNA (2000) (14)
- Exploring the Chemoselectivity towards Cysteine Arylation by Cyclometallated AuIII Compounds: New Mechanistic Insights (2020) (14)
- Highly luminescent metallacages featuring bispyridyl ligands functionalised with BODIPY for imaging in cancer cells. (2019) (14)
- The antifibrotic potential of a sustained release formulation of a PDGF&bgr;‐receptor targeted rho kinase inhibitor (2019) (13)
- Biological Properties of IRIM, the Iridium(III) Analogue of (Imidazolium (Bisimidazole) Tetrachlororuthenate) (ICR) (2000) (13)
- Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B. (2010) (12)
- Unveiling the Mechanisms of Aquaglyceroporin-3 Water and Glycerol Permeation by Metadynamics. (2019) (12)
- Immunohistochemical study of carbonic anhydrase isozymes in human skin. (2003) (12)
- Gold(III) Pyridine-Benzimidazole Complexes as Aquaglyceroporin Inhibitors and Antiproliferative Agents (2018) (12)
- Antiplasmodial Effects of a few Selected Natural Flavonoids and their Modulation of Artemisinin Activity (2008) (11)
- Insights into the strong in-vitro anticancer effects for bis(triphenylphosphane)iminium compounds having perchlorate, tetrafluoridoborate and bis(chlorido)argentate anions. (2015) (11)
- N-Heterocyclic carbenes as “smart” gold nanoparticle stabilizers: State-of-the art and perspectives for biomedical applications (2021) (11)
- An Organogold Compound as Potential Antimicrobial Agent against Drug‐Resistant Bacteria: Initial Mechanistic Insights (2021) (11)
- Nitrate as a probe of cytochrome c surface: crystallographic identification of crucial "hot spots" for protein-protein recognition. (2014) (11)
- Gold organometallics with biological properties (2014) (10)
- Bio-based and bio-inspired adhesives from animals and plants for biomedical applications (2022) (10)
- On the Mechanism of Gold/NHC Compounds Binding to DNA G-Quadruplexes: Combined Metadynamics and Biophysical Methods (2018) (10)
- Carbonic Anhydrase Inhibitors: Synthesis and Inhibition Against Isozymes I, II and IV of Topically Acting Antiglaucoma Sulfonamides Incorporating cis-5-Norbornene-endo-3-Carboxy-2-Carboxamido Moieties (2001) (9)
- The Influence of Auranofin, a Clinically Established Antiarthritic Gold Drug, on Bone Metabolism: Analysis of Its Effects on Human Multipotent Adipose‐Derived Stem Cells, Taken as a Model (2008) (9)
- Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo. (2021) (9)
- Carbonic Anhydrase Inhibitors: Aliphatic N-phosphorylated Sulfamates--A Novel Zinc-anchoring Group Leading to Nanomolar Inhibitors (2004) (8)
- Evidence for the participation of activated oxygen species and the resulting peroxidation of lipids in the killing of cultured hepatocytes by aryl halides. (1990) (8)
- Gold(III) Compounds as Anticancer Agents: Relevance of Gold—Protein Interactions for Their Mechanism of Action (2008) (8)
- Gold(I) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro (2014) (8)
- Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases (2022) (8)
- Non-conventional trans-platinum complexes functionalized with RDG peptides: chemical and cytototoxicity studies (2017) (8)
- Exo-Functionalized Metallacages as Host-Guest Systems for the Anticancer Drug Cisplatin (2019) (8)
- Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands. (2019) (8)
- Toward anticancer gold-based compounds targeting PARP-1: a new case study (2016) (7)
- Aquaporin-driven hydrogen peroxide transport: a case of molecular mimicry? (2020) (6)
- Cyclodextrin metal-organic frameworks and derivatives: recent developments and applications. (2022) (6)
- Human-based Systems for Translational Research (2015) (6)
- Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags. (2020) (6)
- Chapter 3:Translational Research in Pharmacology and Toxicology Using Precision-Cut Tissue Slices (2014) (5)
- Potent in vitro antiproliferative properties for a triplatinum cluster toward triple negative breast cancer cells. (2016) (5)
- Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni (2020) (4)
- Editorial: Supramolecular Metal-Based Entities for Biomedical and Biological Applications (2019) (4)
- Human Red Blood Cell Uptake and Sequestration of Arsenite and Selenite: Evidence of Seleno-bis(S-glutathionyl) Arsinium Ion Formation in Human Cells. (2020) (4)
- Mechanistic Insights into Gold Organometallic Compounds and their Biomedical Applications. (2017) (4)
- Insights into the Selectivity Mechanisms of Grapevine NIP Aquaporins (2020) (4)
- Indenyl and allyl palladate complexes bearing N‐heterocyclic carbene ligands: an easily accessible class of new anticancer drug candidates (2022) (4)
- Inorganic Compounds as Aquaporin Substrates or as Potent Inhibitors: A Coordination Chemistry Point of View (2018) (4)
- Organometallic gold-based anticancer therapeutics (2018) (3)
- Modulation of the in vitro antimalarial effects of artemisinin by selected flavonoids and by reducing agents (2007) (3)
- Supplementary Information Available The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods (2017) (3)
- A multi-technique approach to predicting the molecular structure of cuprizone in the gas phase and in the crystalline state (2008) (3)
- Frontiers in radionuclide imaging and therapy, a chemical journey from naturally radioactive elements to targeted theranostic agents. (2017) (3)
- C−C Cross‐Couplings from a Cyclometalated Au(III) C∧ N Complex: Mechanistic Insights and Synthetic Developments (2021) (3)
- Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems: synthesis, characterisation and cellular accumulation studies. (2022) (2)
- Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations. (2021) (2)
- Bioinorganic supramolecular coordination complexes and their biomedical applications (2022) (2)
- Interfering with Metabolic Profile of Triple‐Negative Breast Cancers Using Rationally Designed Metformin Prodrugs (2021) (2)
- Bottom‐up Synthesis of Water‐Soluble Gold Nanoparticles Stabilized by N‐Heterocyclic Carbenes: From Structural Characterization to Applications (2022) (2)
- Cover Feature: An Organometallic Gold(I) Bis‐N‐Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells (Chem. Eur. J. 67/2020) (2020) (2)
- X-ray crystallograpy of the antiepileptic drug zonisamide with CA II (2005) (2)
- Optimization of the Pharmacokinetic Profile of [99mTc]Tc-N4-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence (2022) (1)
- Competitive profiling of ligandable cysteines in Staphylococcus aureus with an organogold compound. (2022) (1)
- Xanthine-based gold(I) N-Heterocyclic Carbene complexes (2013) (1)
- “Organometallic Chemistry of Gold-Based Drugs” (2021) (1)
- Multinuclear Cytotoxic Metallodrugs (2014) (1)
- Aquaporin Functional Detection: Basic Concepts on Water and Solute Permeation (2018) (1)
- Gold organometallics with biological properties: Part One Medicinal Chemistry 1 (2015) (1)
- New Gold(I) Organometallic Compounds with Biological Activity in Cancer Cells (Eur. J. Inorg. Chem. 27/2014) (2014) (1)
- Supramolecular metal-based molecules and materials for biomedical applications (2021) (1)
- First-row transition-metal norharmane compounds (2015) (1)
- PET imaging of self-assembled 18F-labelled Pd2L4 metallacages for anticancer drug delivery. (2022) (1)
- Gold Complexes in Anticancer Therapy: From New Design Principles to Particle-Based Delivery Systems. (2023) (1)
- Frontispiece: Host–Guest Interactions in a Metal–Organic Framework Isoreticular Series for Molecular Photocatalytic CO 2 Reduction (2021) (1)
- Peptides: Chemical and Cytototoxicity Studies (2018) (1)
- The Beauty of Gold: Knowledge of Mechanisms Leads to Different Applications of Organogold Compounds in Medicine and Catalysis (2021) (1)
- Fluorine containing aromatic/heterocyclic sulfonamides as topical intraocular pressure lowering agents with prolonged duration of action (2003) (1)
- Synthesis, antiproliferative and fluorescence properties of new Pt-Au and Ru-Au bimetallic complexes bearing a glucose moiety. (2014) (0)
- Competitive Profiling of Ligandable Cysteines in Staphylococcus aureus with an Organogold Compound (2022) (0)
- “Dynamical Docking” of Cyclic Dinuclear Au(I) Bis-N-heterocyclic Complexes Facilitates Their Binding to G-Quadruplexes (2022) (0)
- Exploring with the anticancer gold-based compound-Auphen the mechanism(s) by which Aquaporin-3 participates in cell proliferation (2013) (0)
- Inside Cover: Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands (ChemMedChem 1/2010) (2010) (0)
- Mechanisms of Fluid Transport in Cells and Epithelia (2016) (0)
- Application of Mass Spectrometric Techniques to Delineate the Modes-of-Action of Anticancer Metallodrugs (2013) (0)
- Gold compounds as promising chemical probes and targeted therapeutic agents (2015) (0)
- Connecting copper and cancer: from transition metal signalling to metalloplasia (2021) (0)
- Cover Picture: Cytotoxic Gold(I) N‐heterocyclic Carbene Complexes with Phosphane Ligands as Potent Enzyme Inhibitors (ChemMedChem 6/2014) (2014) (0)
- Silver(I) bis(norharmane) compounds: synthesis, 3D structures and cytostatic properties (2014) (0)
- For functional studies , Saccharomyces cerevisiae , 10560-6 B MAT α leu 2 : : hisG trp 1 : : hisG (2018) (0)
- Gold-based compounds as inhibitors of ACP5 and uses thereof (2016) (0)
- Harvesting Free Energy Landscapes in Biological Systems (2019) (0)
- Designing of novel carbonic anhydrase inhibitors and activators. (2004) (0)
- A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages (2017) (0)
- Indenyl and Allyl Palladate Complexes Bearing N ‐Heterocyclic Carbene Ligands: an Easily Accessible Class of New Anticancer Drug Candidates (2022) (0)
- Development of precision-cut kidney slices for testing toxicity and disposition of platinum anticancer drugs in tubular cells (2015) (0)
- Hepatobiliary, Salivary Glands and Pancreatic Aquaporins in Health and Disease (2018) (0)
- Synthesis of metal-based bioconjugates with RGD peptides to achieve targeted therapeutic and imaging anticancer agents (2015) (0)
- Targeting aquaglyceroporin-3 with Gold(III) anticancer compounds (2015) (0)
- Front Cover: Comparing the Antileishmanial Activity of Gold(I) and Gold(III) Compounds in L. amazonensis and L. braziliensis in Vitro (ChemMedChem 22/2020) (2020) (0)
- Zinc Finger Proteins Cyclometalated Au III Complexes for Cysteine Arylation in Zinc Finger Protein Domains : towards Controlled Reductive Elimination (2019) (0)
- A multilevel theoretical study to disclose the binding 1 mechanisms of gold ( III ) bipyridyl compounds as selective 2 aquaglyceroporin inhibitors (2017) (0)
- Xray structure of cisplatin-protein interactions (2006) (0)
- XAS/XRD complementary data on metallodrugs and their proteins complexes (2011) (0)
- The gold-based compound Auphen affects proliferation rate of AQP3 expressing cells (2012) (0)
- Aquaporins in Carcinogenesis: Water and Glycerol Channels as New Potential Drug Targets (2018) (0)
- Human Red Blood Cell Uptake and Sequestration of Arsenite and Selenite: Evidence for the Formation of a Protective Glutathione Conjugate (2020) (0)
- Mitochondria-targeted metal–organic frameworks for cancer treatment (2023) (0)
- Aquaporins as Drug Targets (2016) (0)
- Aquaporin inhibition by gold compounds (2014) (0)
- Effect of a gold-based compound on AQP3 permeability and cell proliferation of tumor cells (2013) (0)
- Fluorescent organometallic gold(I) N-heterocyclic carbene complexes: synthesis and biological activities (2014) (0)
- Radiolabeled supramolecular coordination complexes targeted to somatostatin receptors (2022) (0)
- Xray structure of cisplatin-protein interactions: selective platination of his 19 in superoxide dismutase (2006) (0)
- Mammals aquaporin modulators: screening by heterologous expression in Saccharomyces cerevisiae (2013) (0)
- Screening aquaporin modulators by heterologous expression in yeast (2013) (0)
- Faculty Opinions recommendation of PEGylated N-Heterocyclic Carbene Anchors Designed To Stabilize Gold Nanoparticles in Biologically Relevant Media. (2021) (0)
- Silver(I) bis(norharmane) compounds (2014) (0)
- Faculty Opinions recommendation of Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines. (2021) (0)
- Crystal structure of cisplatinated bovine Cu,Zn superoxide dismutase (2006) (0)
- METAL-BASED CHEMICAL ENTITIES: OPPORTUNITIES IN CHEMICAL BIOLOGY AND TO ACHIEVE TARGETED THERAPEUTIC AGENTS (2016) (0)
- Electron transfer complexes: Experimental mapping of the redox-dependent cytochrome c electrostatic surface (2012) (0)
- Assessment of anticancer metallodrugs toxicity in precision cut kidney slices (PCKS) (2015) (0)
- In My Element : Gold (2019) (0)
- Iminophosphorane d(8) transition metal complexes as potential anticancer agents via a non-cisplatin mode of action (2013) (0)
- First-row transition-metal norharmane compounds : Synthesis, characterization, structure and antiproliferative effects in cancer cells (2015) (0)
- X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme (2007) (0)
- Faculty Opinions recommendation of Metal substrate catalysis in the confined space for platinum drug delivery. (2022) (0)
- The use of precision-cut tissue slices for toxicity testing of drugs (2015) (0)
- Blood–brain barrier penetrating peptide-based radioligands targeting the EGFR:EGFRvIII receptors (2022) (0)
- Carbonic Anhydrase Inhibitors: Topically Acting Antiglaucoma Sulfonamides Incorporating Esters and Amides of 3‐ and 4‐Carboxybenzolamide. (2003) (0)
- Aquaporin inhibition by a gold-based compound (2012) (0)
- Targeting cysteine residues of biomolecules (2002) (0)
- Multinuclear Cytotoxic Metallodrugs: Synthesis and Biological Studies of Novel Bimetallic Titanium-Ruthenium and Gold Complexes (2014) (0)
- Aquaporin-3 is involved in NLRP3-inflammasome activation contributing to the setting of inflammatory response (2020) (0)
- Revealing pH gating of human aquaporin 7 through yeast expression (2015) (0)
- "Gold-finger" domains formation (2015) (0)
- Self-assembled Pd2L4 coordination cages as potential drug delivery systems for anticancer agents (2015) (0)
- Reactivity of zinc fingers with Au(III) complexes (2014) (0)
- Metals in Medicine (2022) (0)
- CHAPTER 9. Supramolecular Metal-based Structures for Applications in Cancer Therapy (2019) (0)
- The crystal structure of human CA II bound to a strong benzenesulfonamide inhibitor (2005) (0)
- Front Cover: Self‐Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity (Eur. J. Inorg. Chem. 33/2016) (2016) (0)
- Exploring metal complexes-protein/peptide interactions by high resolution mass spectrometry (2009) (0)
- Organometallic Pillarplexes that bind DNA 4-way Holliday Junctions and Forks (2023) (0)
- Cysteine-modifying agents (2002) (0)
- Elucidating the Multimodal Anticancer Mechanism of an Organometallic Terpyridine Platinum(II) N-Heterocyclic Carbene Complex against Triple-Negative Breast Cancer In Vitro and In Vivo. (2023) (0)
- Gold(I) NHC-based homo- and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents (2015) (0)
- Exploring the Gating Mechanisms of Aquaglyceroporins: New Clues for Inhibitor’s Design? (2016) (0)
- Faculty Opinions recommendation of Mechanistic and structural basis for inhibition of copper trafficking by platinum anticancer drugs. (2021) (0)
- Editorial overview: Bioinorganic chemistry. (2021) (0)
- Luminescent iminophosphorane d(8) transition metal coordination complexes as potential anticancer agents (2012) (0)
- CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR (2004) (0)
- Investigation of Solvatomorphism and Its Photophysical Implications for Archetypal Trinuclear Au3(1-Methylimidazolate)3 (2021) (0)
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