Anna K. Mapp
#93,144
Most Influential Person Now
Biochemist
Anna K. Mapp's AcademicInfluence.com Rankings
Anna K. Mappbiology Degrees
Biology
#10956
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#14322
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Biochemistry
#2581
World Rank
#2750
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Biology
Anna K. Mapp's Degrees
- PhD Biochemistry Stanford University
- Bachelors Chemistry University of California, Berkeley
Why Is Anna K. Mapp Influential?
(Suggest an Edit or Addition)According to Wikipedia, Anna Kathryn Mapp is an American chemist and the Edwin Vedejs collegiate professor of Chemistry. In 2013, Mapp joined the Michigan Life Sciences Institute as a research professor. Mapp served as the Director of the Program in Chemical Biology at the University of Michigan until 2019 when she accepted a position as the Associate Dean for Academic Programs and Initiatives at the University of Michigan Rackham graduate school.
Anna K. Mapp's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Activation of gene expression by small molecule transcription factors. (2000) (152)
- Succinct Synthesis of β-Amino Acids via Chiral Isoxazolines (2005) (108)
- Fine-tuning multiprotein complexes using small molecules. (2012) (87)
- Modular design of artificial transcription factors. (2002) (84)
- A small molecule transcriptional activation domain. (2004) (79)
- Direct Measurements of Oscillatory Glycolysis in Pancreatic Islet β-Cells Using Novel Fluorescence Resonance Energy Transfer (FRET) Biosensors for Pyruvate Kinase M2 Activity*♦ (2013) (73)
- Towards a minimal motif for artificial transcriptional activators. (2001) (68)
- Ordering a dynamic protein via a small-molecule stabilizer. (2013) (68)
- A Concise Approach to Structurally Diverse β-Amino Acids (2003) (68)
- A TAD further: exogenous control of gene activation. (2007) (68)
- Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors. (2009) (60)
- Prepaying the entropic cost for allosteric regulation in KIX (2014) (58)
- Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300. (2012) (56)
- Profiling the dynamic interfaces of fluorinated transcription complexes for ligand discovery and characterization. (2012) (56)
- Direct and Propagated Effects of Small Molecules on Protein–Protein Interaction Networks (2015) (51)
- Caught in the act: covalent cross-linking captures activator-coactivator interactions in vivo. (2011) (50)
- Chemical approaches to transcriptional regulation. (2005) (50)
- Total Synthesis of Myxalamide A. (1999) (49)
- Phosphorylation of Nanog is Essential to Regulate Bmi1 and Promote Tumorigenesis (2013) (44)
- Impact of nonnatural amino acid mutagenesis on the in vivo function and binding modes of a transcriptional activator. (2009) (44)
- Transcriptional Switches: Chemical Approaches to Gene Regulation* (2010) (40)
- Synthesis of a 2,7-Dioxatricyclo[4.2.1.03,8]nonane: A Model Study for Possible Application in a Synthesis of Dictyoxetane (1996) (38)
- Covalent inhibition of NSD1 histone methyltransferase (2020) (37)
- Transcriptional up-regulation in cells mediated by a small molecule. (2007) (36)
- X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition (2017) (33)
- Modulating the masters: chemical tools to dissect CBP and p300 function. (2018) (32)
- Targeting the transcriptional machinery with unique artificial transcriptional activators. (2003) (32)
- From Fuzzy to Function: The New Frontier of Protein-Protein Interactions. (2017) (31)
- FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions. (2014) (30)
- Dissecting allosteric effects of activator–coactivator complexes using a covalent small molecule ligand (2014) (30)
- Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer. (2009) (24)
- Preparation of thioesters for the ligation of peptides with non-native substrates☆ (2000) (23)
- A phosphorimidate rearrangement for the facile and selective preparation of allylic amines. (2004) (23)
- Transient-state Kinetic Analysis of Transcriptional Activator·DNA Complexes Interacting with a Key Coactivator* (2011) (22)
- Palladium-catalyzed [3,3]-rearrangement for the facile synthesis of allenamides. (2010) (22)
- Discovery of Enzymatic Targets of Transcriptional Activators via in Vivo Covalent Chemical Capture. (2016) (21)
- Regulating transcription: a chemical perspective. (2003) (21)
- A Bifunctional Amino Acid Enables Both Covalent Chemical Capture and Isolation of in Vivo Protein–Protein Interactions (2017) (21)
- Thermal and catalyzed [3,3]-phosphorimidate rearrangements. (2005) (21)
- Stereochemical promiscuity in artificial transcriptional activators. (2005) (20)
- A high-resolution interaction map of three transcriptional activation domains with a key coactivator from photo-cross-linking and multiplexed mass spectrometry. (2009) (20)
- Targeting transcription is no longer a quixotic quest. (2015) (20)
- Transforming ligands into transcriptional regulators: building blocks for bifunctional molecules. (2011) (19)
- Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators. (2011) (19)
- The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia (2021) (17)
- Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics. (2009) (17)
- Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators (2018) (17)
- Sequence context and crosslinking mechanism affect the efficiency of in vivo capture of a protein-protein interaction. (2014) (17)
- Functional specificity of artificial transcriptional activators. (2005) (16)
- Unexpected specificity within dynamic transcriptional protein–protein complexes (2020) (13)
- Selective Modulation of Dynamic Protein Complexes. (2020) (13)
- BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. (2018) (13)
- Collision-Induced Unfolding Reveals Unique Fingerprints for Remote Protein Interaction Sites in the KIX Regulation Domain (2018) (12)
- A Synthetic Loop Replacement Peptide That Blocks Canonical NF-κB Signaling. (2016) (12)
- miR-124 Regulates the Epithelial-Restricted with Serine Box/Epidermal Growth Factor Receptor Signaling Axis in Head and Neck Squamous Cell Carcinoma (2015) (12)
- Expanding the repertoire of small molecule transcriptional activation domains. (2009) (11)
- Unraveling the Mechanism of a Potent Transcriptional Activator* (2005) (11)
- The role of HTS in drug discovery at the University of Michigan. (2014) (10)
- Protein cross-linking capillary electrophoresis at increased throughput for a range of protein-protein interactions. (2018) (10)
- [3,3]-rearrangements of phosphonium ylides. (2006) (9)
- Assessing the permissiveness of transcriptional activator binding sites. (2008) (9)
- Unexpected Specificity within Dynamic Transcriptional Protein-Protein Complexes (2020) (9)
- Genetic and Chemical Targeting of Epithelial-Restricted with Serine Box Reduces EGF Receptor and Potentiates the Efficacy of Afatinib (2013) (9)
- Synthesis and biological evaluation of pharbinilic acid and derivatives as NF-κB pathway inhibitors. (2015) (8)
- Converting inactive peptides into potent transcriptional activators. (2006) (8)
- A Dual-Site Inhibitor of CBP/p300 KIX is a Selective and Effective Modulator of Myb. (2021) (8)
- Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide. (2018) (8)
- Norstictic acid is a selective allosteric transcriptional regulator (2021) (8)
- Biosensors for pyruvate kinase M 2 1 Direct Measurements of Oscillatory Glycolysis in Pancreatic Islet β-cells using Novel FRET Biosensors for Pyruvate Kinase M 2 Activity * (2013) (7)
- Roles for a lipid phosphatase in the activation of its opposing lipid kinase (2020) (7)
- TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform (2021) (7)
- A flexible synthetic route to isoxazolidine β-proline analogs (2009) (6)
- Tra1 as a screening target for transcriptional activation domain discovery. (2009) (6)
- Synergistic enhancement of the potency and selectivity of small molecule transcriptional inhibitors. (2012) (6)
- TRIC: Capturing the direct cellular targets of promoter‐bound transcriptional activators (2016) (5)
- Research into selective biomarkers of erythrocyte exposure to organophosphorus compounds. (2009) (5)
- Copper-Mediated Radiocyanation of Unprotected Amino Acids and Peptides. (2022) (5)
- Synthesis and Structural Characteristics of Geminally Disubstituted β-Amino Acids (2004) (5)
- Bifunctional ligands allow deliberate extrinsic reprogramming of the glucocorticoid receptor. (2014) (4)
- Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKα. (2019) (4)
- Artificial Transcriptional Activation Domains (2005) (4)
- Electron‐deficient p‐benzoyl‐l‐phenylalanine derivatives increase covalent chemical capture yields for protein–protein interactions (2019) (3)
- Finding their groove; bifunctional molecules arrest growth of cancer cells. (2004) (3)
- Covalent Chemical Cochaperones of the p300/CBP GACKIX Domain (2018) (3)
- Correction: Graduate Education in Chemical Biology at the University of Michigan (2006) (3)
- Disrupting Mediator with a Short Peptide Ligand (2007) (2)
- Graduate education chemical biology at the University of Michigan. (2006) (2)
- Transcription Factors (2004) (1)
- A concise approach to structurally diverse beta-amino acids. (2003) (1)
- Succinct synthesis of beta-amino acids via chiral isoxazolines. (2005) (1)
- Transcription-Based Therapeutics (2008) (1)
- Succinct Synthesis of β‐Amino Acids via Chiral Isoxazolines. (2005) (1)
- A higher degree of difficulty. (2007) (0)
- Synthesis and Structural Characteristics of Geminally Disubstituted β-Amino Acids. (2004) (0)
- CORRELATING MOLECULAR STRUCTURE WITH IN VITRO FUNCTION FOR SAR (2013) (0)
- Faculty Opinions recommendation of Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. (2020) (0)
- Regulating Transcription: A Chemical Perspective (2003) (0)
- In this issue (2016) (0)
- Capturing transient transcriptional activator‐coactivator complexes with large and small molecules (2013) (0)
- Synthesis of a 2,7‐Dioxatricyclo(4.2.1.03,8)nonane: A Model Study for Possible Application in a Synthesis of Dictyoxetane (XI). (1997) (0)
- A Dual-Site Inhibitor of CBP/p300 KIX is a Selective and Effective Modulator of Myb (2021) (0)
- A Concise Approach to Structurally Diverse α‐Amino Acids. (2003) (0)
- Palladium‐Catalyzed [3,3]‐Rearrangement for the Facile Synthesis of Allenamides. (2010) (0)
- Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states (2022) (0)
- Faculty Opinions recommendation of Structural basis for finding OG lesions and avoiding undamaged G by the DNA glycosylase muty. (2020) (0)
- Capturing the transient, in vivo binding partners of transcriptional activators using a genetically incorporated photo‐crosslinking amino acid (2013) (0)
- Dissecting protein complexes with small molecules (2008) (0)
- Total Synthesis of Zaragozic Acid A (Squalestatin S1) (XIII). Synthesis of the Relay Compound (XII). (2010) (0)
- Copper mediated radiocyanation of aryl halides (2022) (0)
- Human disease and transcriptional misregulation have strengthened. (2011) (0)
- Targeting Prostate Cancer with Bifunctional Modulators of the Androgen Receptor (2014) (0)
- Expanding the Scope of Small Molecule Transcription Activators (2008) (0)
- Transforming Ligands into Transcriptional Regulators: Building Blocks for Bifunctional Molecules (2011) (0)
- [3,3]‐Rearrangements of Phosphonium Ylides. (2006) (0)
- Kinetic Characterization of Transcriptional Activator‐Coactivator Interactions (2008) (0)
- Contents list. (2018) (0)
- Faculty Opinions recommendation of The Progesterone 5β-Reductase/Iridoid Synthase Family: A Catalytic Reservoir for Specialized Metabolism across Land Plants. (2020) (0)
- Arthur C. Cope Scholar Awards and Eli Lilly Award (2012) (0)
- Blocking the Metastatic Phenotype in Prostate Cancer Through Direct Inhibition of the ETV/PEA3 Transcription Factors (2016) (0)
- Faculty Opinions recommendation of Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells. (0)
- Faculty Opinions recommendation of A proteome-wide atlas of lysine-reactive chemistry. (2022) (0)
- Crystal Structure of GACKIX L664C Tethered to 1-10 (2013) (0)
- A lipopeptidomimetic of transcriptional activation domains selectively disrupts Med25 PPIs (2023) (0)
- Modulating Transcription with Artificial Regulators (2004) (0)
- Mechanistic comparison of structurally divergent transcriptional coactivators through covalent activator‐coactivator complexes (2017) (0)
- Several novel approaches to developing therapeutics that target both bacterial and human proteins. (2008) (0)
- Supporting Information A Bifunctional Amino Acid Enables Both Covalent Chemical Capture and Isolation of in Vivo Protein – Protein Interactions (2017) (0)
- Faculty Opinions recommendation of Secondary amine selective Petasis (SASP) bioconjugation. (2020) (0)
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