Anne Spurkland
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Norwegian professor of immunology
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Why Is Anne Spurkland Influential?
(Suggest an Edit or Addition)According to Wikipedia, Anne Spurkland is a Norwegian anatomist and immunologist. She finished the cand.med. degree at the University of Oslo in the autumn of 1986. In 1993 she delivered the doctoral thesis HLA Associated Genetic Susceptibility to Multiple Sclerosis and Coeliac disease, gaining the dr.med. degree.
Anne Spurkland's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis (2011) (2511)
- Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis (2013) (1170)
- Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility (2019) (589)
- A high-density screen for linkage in multiple sclerosis. (2005) (308)
- VEGF receptor‐2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis (2005) (289)
- Class II HLA interactions modulate genetic risk for multiple sclerosis (2015) (262)
- Features of autoimmune hepatitis in primary sclerosing cholangitis: An evaluation of 114 primary sclerosing cholangitis patients according to a scoring system for the diagnosis of autoimmune hepatitis (1996) (198)
- VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd (2012) (189)
- CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis. (1999) (169)
- HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations. (1999) (162)
- The expanding genetic overlap between multiple sclerosis and type I diabetes (2009) (157)
- The amino acid at position 57 of the HLA-DQ beta chain and susceptibility to develop insulin-dependent diabetes mellitus. (1989) (150)
- Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. (2013) (149)
- HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis. (1991) (149)
- Distribution of HLA-DRB1, -DQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus. (1991) (149)
- K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location. (1994) (146)
- Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis. (2004) (145)
- HLA-DR and -DQ genotypes of celiac disease patients serologically typed to be non-DR3 or non-DR5/7. (1992) (141)
- Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex (2004) (127)
- Distribution of HLA class II alleles among Norwegian Caucasians. (1990) (124)
- Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor (2009) (123)
- Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (α1*0501, (β1*02) or the HLA-DQ (α1*03, (β1*0302) heterodimers (1997) (119)
- The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility (2017) (113)
- Refining genetic associations in multiple sclerosis (2008) (108)
- Association of the tumour necrosis factor α −308 but not the interleukin 10 −627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis (2001) (101)
- Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk (2018) (98)
- p21‐ras‐peptide‐specific T‐cell responses in a patient with colorectal cancer. CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation (13Gly → Asp) (2007) (93)
- A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis (2002) (86)
- Primary sclerosing cholangitis is associated to an extended B8‐DR3 haplotype including particular MICA and MICB alleles (2001) (83)
- The impact of HLA‐A and ‐DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patients (2007) (79)
- Memory T cells of a patient with follicular thyroid carcinoma recognize peptides derived from mutated p21 ras (Gln-->Leu61). (1992) (79)
- Coordinated Expression of DNAM-1 and LFA-1 in Educated NK Cells (2015) (75)
- Molecular Cloning of a T Cell-specific Adapter Protein (TSAd) Containing an Src Homology (SH) 2 Domain and Putative SH3 and Phosphotyrosine Binding Sites* (1998) (74)
- Susceptibility to develop celiac disease is primarily associated with HLA-DQ alleles. (1990) (72)
- IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci (2010) (72)
- A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis (2010) (72)
- Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (alpha 1*0501, beta 1*02) or the HLA-DQ (alpha 1*03, beta 1*0302) heterodimers. (1997) (70)
- HLA class II alleles and heterogeneity of juvenile rheumatoid arthritis. DRB1*0101 may define a novel subset of the disease. (1993) (70)
- A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis (2009) (66)
- Cholangiocarcinoma in primary sclerosing cholangitis: K-ras mutations and Tp53 dysfunction are implicated in the neoplastic development. (2000) (63)
- The HLA-DR3,DQ2 heterozygous genotype is associated with an accelerated progression of primary sclerosing cholangitis. (2001) (59)
- Rheumatoid arthritis may be primarily associated with HLA-DR4 molecules sharing a particular sequence at residues 67-74. (1990) (58)
- The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis (2001) (57)
- Killer immunoglobulin‐like receptor ligand HLA‐Bw4 protects against multiple sclerosis (2009) (56)
- Cutting Edge: T Cell-Specific Adapter Protein Inhibits T Cell Activation by Modulating Lck Activity (2000) (54)
- HLA matching of unrelated bone marrow transplant pairs: direct sequencing of in vitro amplified HLA-DRB1 and -DQB1 genes using magnetic beads as solid support. (1993) (53)
- Particular HLA-DQ αβ Heterodimer Associated With IDDM Susceptibility in Both DR4-DQw4 Japanese and DR4-DQw8/DRw8-DQw4 Whites (1991) (52)
- Myasthenia gravis patients with thymus hyperplasia and myasthenia gravis patients with thymoma display different HLA associations. (1991) (52)
- Regional cardiac expression and concentration of natriuretic peptides in patients with severe chronic heart failure. (2001) (50)
- Demonstration of identical expanded clones within both CD8+ CD28+ and CD8+ CD28− T cell subsets in HIV type 1‐infected individuals (1998) (43)
- Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus (2011) (43)
- Association of matrix metalloproteinase-1 and -3 promoter polymorphisms with clinical subsets of Norwegian primary sclerosing cholangitis patients. (2004) (42)
- IL 12 A , MPHOSPH 9 / CDK 2 AP 1 and RGS 1 are novel multiple sclerosis susceptibility loci (2010) (41)
- Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus (2012) (39)
- Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes. (2007) (38)
- The HLA‐DQ(α1*0102, β1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA‐DR(α1*01, β1*1501) heterodimer (1997) (38)
- The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells (2016) (37)
- HLA-DQ antigens and DQ beta amino acid 57 of Japanese patients with insulin-dependent diabetes mellitus: detection of a DRw8DQw8 haplotype. (1989) (36)
- A strong impact of matching for a limited number of HLA-DR antigens on graft survival and rejection episodes: a single-center study of first cadaveric kidneys to nonsensitized recipients. (1998) (33)
- Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk (2018) (33)
- Molecular genetic studies of natives on Easter Island: evidence of an early European and Amerindian contribution to the Polynesian gene pool. (2007) (33)
- T cell epitopes encompassing the mutational hot spot position 61 of p21 ras. Promiscuity in ras peptide binding to HLA (1994) (33)
- Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene (2004) (31)
- Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients (2005) (31)
- X chromosome inactivation in females with multiple sclerosis (2007) (30)
- T Cell Specific Adapter Protein (TSAd) Interacts with Tec Kinase ITK to Promote CXCL12 Induced Migration of Human and Murine T Cells (2010) (29)
- HLA profile of three ethnic groups living in the North-Western region of Russia. (2002) (28)
- The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation (2016) (28)
- Concordance for disease course and age of onset in Scandinavian multiple sclerosis coaffected sib pairs (2004) (27)
- The C terminus of T cell‐specific adapter protein (TSAd) is necessary for TSAd‐mediated inhibition of Lck activity (2005) (27)
- Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis (2010) (26)
- Modulation of Lck Function through Multisite Docking to T Cell-specific Adapter Protein* (2008) (25)
- Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy (2015) (23)
- HLA-DRB1, -DQA1, -DQB1, -DPA1 and -DPB1 genes in Japanese multiple sclerosis patients. (1991) (23)
- No association of multiple sclerosis to alleles at the TAP2 locus. (1994) (22)
- Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. (2006) (21)
- The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192 (2014) (20)
- Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients (2003) (20)
- Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing–remitting multiple sclerosis (2015) (20)
- No linkage or association of the nitric oxide synthase genes to multiple sclerosis (2001) (19)
- The HLA-DQ(alpha 1*0102, beta 1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA-DR(alpha 1*01, beta 1*1501) heterodimer. (1997) (18)
- Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7 (2006) (18)
- The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1 (2000) (17)
- Novel HLA-DR2 and -DR3 haplotypes among Norwegian Caucasians. (1991) (17)
- Isolation and characterization of a human pseudogene for the regulatory subunit RI alpha of cAMP-dependent protein kinases and its sublocalization on chromosome 1. (1993) (17)
- CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell‐Specific Adaptor Protein (2017) (16)
- Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells (2015) (16)
- Contrasting cardiac regional responses of A-type and B-type natriuretic peptide to experimental chronic heart failure. (2000) (16)
- Activation and proliferation of CD8+ T cells in lymphoid tissues of HIV-1-infected individuals in the absence of the high-affinity IL-2 receptor. (1998) (15)
- T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells (2015) (15)
- Report from the HLA class II typing by PCR-SSP Multicentre Study. (1997) (15)
- Transcriptional Activation of the SH2D2A Gene Is Dependent on a Cyclic Adenosine 5′-Monophosphate-Responsive Element in the Proximal SH2D2A Promoter1 (2004) (14)
- The SH2D2A gene and susceptibility to multiple sclerosis (2008) (14)
- Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk (2020) (13)
- Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd (2018) (13)
- Solubility of recombinant Src homology 2 domains expressed in E. coli can be predicted by TANGO (2014) (13)
- Method for avoiding PCR-inhibiting contaminants when eluting DNA from polyacrylamide gels. (2000) (12)
- Molecular analysis of the complementarity determining region 3 of the human T cell receptor beta chain. Establishment of a reference panel of CDR3 lengths from phytohaemagglutinin activated lymphocytes. (1999) (12)
- Expression of SH2D2A in T-cells is regulated both at the transcriptional and translational level. (2008) (12)
- cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd): expression in T and NK cells (2004) (11)
- Microchimerism in immune competent patients related to the leukocyte content of transfused red blood cell concentrates. (2004) (11)
- Physical separation of HLA-A alleles by denaturing high-performance liquid chromatography. (2003) (11)
- No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis (2006) (10)
- Linkage disequilibrium between DPA1 and DPB1 alleles among Norwegian Caucasoids and Japanese. (1992) (9)
- Structure function analysis of SH 2 D 2 A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH 2 D 2 A exon 7 (2006) (9)
- Strict Adherence to a Common Rank Order of T‐Cell Receptor Vβ Usage in Human Leucocyte Antigen Disparate Individuals (1996) (9)
- SH2D2A Modulates T Cell Mediated Protection to a B Cell Derived Tumor in Transgenic Mice (2012) (8)
- Genetic and molecular approaches to the immunopathogenesis of multiple sclerosis: an update. (2009) (8)
- NR 1 H 3 p . Arg 415 Gln is not associated to multiple sclerosis risk (2018) (7)
- Parent of origin in multiple sclerosis (2008) (7)
- HLA-DR-DQ haplotype frequencies in a Norwegian population. (1992) (7)
- Mapping genes and pathways in autoimmune disease. (2006) (7)
- The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell–specific adapter protein (2019) (6)
- A simple and efficient workflow for generation of knock‐in mutations in Jurkat T cells using CRISPR/Cas9 (2019) (6)
- Heterogeneity of T cells specific for a particular peptide/HLA-DQ complex. (1994) (5)
- Expression of the T-cell-specific adapter protein in oral epithelium. (2010) (5)
- Coding region polymorphisms in T cell signal transduction genes. Prevalence and association to development of multiple sclerosis (2006) (5)
- B‐cell tolerance to the B‐cell receptor variable regions (2013) (5)
- Linkage analysis suggests a region of importance for multiple sclerosis in 3p14–13 (2001) (5)
- Particular HLA-DQ alpha beta heterodimer associated with IDDM susceptibility in both DR4-DQw4 Japanese and DR4-DQw8/DRw8-DQw4 whites. (1991) (4)
- Corrigendum to “Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans” [J. Neuroimmunol. 179 (2006) 108–116] (2007) (4)
- [New gene map for multiple sclerosis]. (2011) (4)
- Adaptor proteins: Flexible and dynamic modulators of immune cell signalling (2020) (4)
- No association between HLA‐DR2 and the sudden infant death syndrome (1992) (4)
- A follow-up study of Nordic multiple sclerosis candidate gene regions (2007) (3)
- The use of modified primer competitors to enhance yields and specificity of HLA class I amplification by polymerase chain reaction (PCR). (2003) (3)
- HLA and Gastrointestinal Diseases (2000) (3)
- High‐throughput analysis of T cell–monocyte interaction in human tuberculosis (2020) (3)
- Genomic HLA-DRB1 matching further improves clinical course after renal transplantation. (1995) (3)
- Reduced MCMV Δm157 viral clearance in the absence of TSAd (2015) (2)
- Genetics in multiple sclerosis: past and future perspectives (2007) (2)
- Tyr192 Regulates Lymphocyte-Specific Tyrosine Kinase Activity in T Cells (2021) (2)
- In vitro analysis of antigen induced T cell-monocyte conjugates by imaging flow cytometry. (2018) (2)
- Expression of the T Cell‐specific Adapter Protein in Human Tissues (2014) (2)
- Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells (2021) (2)
- Studies of the T-cell receptors of T cells recognizing the same HLA molecule. (1993) (2)
- 4-31-11 TNFa1 allele is associated with multiple sclerosis both in Russian and Norwegian caucasians (1997) (1)
- is not associated to multiple sclerosis risk (2019) (1)
- The EFIS vaccination task force expert report (2021) (1)
- Does genomic HLA-DR matching further enhance the effects of serologic DR matching in clinical renal transplantation? (1994) (1)
- Self-reported anatomy skills among Norwegian physicians - Need for improved postgraduate teaching provision (2022) (0)
- Nucleic acid isolation (1994) (0)
- Quantitative analysis of immunological synapse formation using ImageStream cytometry (35.27) (2009) (0)
- Quantitative analysis of immune synapse formation using imaging flow cytometry. (130.18) (2010) (0)
- Genetisk variasjon – nyttig informasjon for hver og en? (2002) (0)
- Need for improved continuing education in anatomy for clinicians in Norway. (2022) (0)
- Editorial: Host immune evasion by Mycobacterium tuberculosis: Current updates (2022) (0)
- [Adopted African children have large stomachs]. (1997) (0)
- Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd (2018) (0)
- Klassisk anatomi i moderne drakt (2016) (0)
- Molecular analysis of the CLEC16A autoimmune risk locus (2014) (0)
- Solid embryologi i dansk oversettelse (2016) (0)
- HLA-A, -B, -Cw,-DQA1,-DQB1 and -DRB1 allele frequencies in a Nentsy population from Russia (2004) (0)
- Association of primary sclerosing cholangitis to the CTLA4 region on chromosome 2q33 (2002) (0)
- Skriving på universitetsnivå (2014) (0)
- Juvenile idiopathic arthritis is associated to a functionally active polymorphism in the SH2D2A gene (2001) (0)
- Gøyal basalmedisinsk håndbok (2022) (0)
- The SH2D2A Gene - Contributions to Our Future Understanding of Multiple Sclerosis (2009) (0)
- In memoriam: Erik Thorsby (1938‐2021) (2021) (0)
- Erik Thorsby (1938–2021) (2021) (0)
- SH 2 D 2 A Proximal-Monophosphate-Responsive Element in the ′ Gene Is Dependent on a Cyclic Adenosine 5 SH 2 D 2 A Transcriptional Activation of the Vartdal and (2004) (0)
- [Genetic variation--useful information for everybody?]. (2002) (0)
- Isolement de l'acide nucleique (1994) (0)
- HLA class II haplotypes in primary sclerosing cholangitis patients from five ethnic groups. (1998) (0)
- Joint meeting of the Association of British Neurologists and the Norwegian Neurological Association on the coastal steamer Hurtigruten, 6-9 May 2001 (2001) (0)
- Tumour Necrosis Factor Receptor Superfamily Member 6 Gene Mutation Detection by Denaturing High‐Performance Liquid Chromatography (2004) (0)
- T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells (2015) (0)
- [Better knowledge about HLA-molecules gives new therapeutic options]. (1994) (0)
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